                         SEQUENCE LISTING

<110>  Universitat Autnoma de Barcelona
 
<120>  Insulin gene therapy

<130>  P6080613PCT

<150>  EP19382447.1
<151>  2019-05-31

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  2
<211>  110
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Leu Trp Met Arg Phe Leu Pro Leu Leu Ala Leu Leu Phe Leu 
1               5                   10                  15      


Trp Glu Ser His Pro Thr Gln Ala Phe Val Lys Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Met Ser Arg Arg Glu Val Glu Asp Pro Gln Val Ala 
    50                  55                  60                  


Gln Leu Glu Leu Gly Gly Gly Pro Gly Ala Gly Asp Leu Gln Thr Leu 
65                  70                  75                  80  


Ala Leu Glu Val Ala Gln Gln Lys Arg Gly Ile Val Asp Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  3
<211>  110
<212>  PRT
<213>  Canis lupus familiaris

<400>  3

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Ala Pro Ala Pro Thr Arg Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Ala Arg Arg Glu Val Glu Asp Leu Gln Val Arg 
    50                  55                  60                  


Asp Val Glu Leu Ala Gly Ala Pro Gly Glu Gly Gly Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ala Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  4
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  4
atggccctgt ggatgcgcct cctgcccctg ctggcgctgc tggccctctg gggacctgac       60

ccagccgcag cctttgtgaa ccaacacctg tgcggctcac acctggtgga agctctctac      120

ctagtgtgcg gggaacgagg cttcttctac acacccaaga cccgccggga ggcagaggac      180

ctgcaggtgg ggcaggtgga gctgggcggg ggccctggtg caggcagcct gcagcccttg      240

gccctggagg ggtccctgca gaagcgtggc attgtggaac aatgctgtac cagcatctgc      300

tccctctacc agctggagaa ctactgcaac tag                                   333


<210>  5
<211>  333
<212>  DNA
<213>  Mus musculus

<400>  5
atggccctgt ggatgcgctt cctgcccctg ctggccctgc tcttcctctg ggagtcccac       60

cccacccagg cttttgtcaa gcagcacctt tgtggttccc acctggtgga ggctctctac      120

ctggtgtgtg gggagcgtgg cttcttctac acacccatgt cccgccgtga agtggaggac      180

ccacaagtgg cacaactgga gctgggtgga ggcccgggag caggtgacct tcagaccttg      240

gcactggagg tggcccagca gaagcgtggc attgtagatc agtgctgcac cagcatctgc      300

tccctctacc agctggagaa ctactgcaac tag                                   333


<210>  6
<211>  333
<212>  DNA
<213>  Canis lupus familiaris

<400>  6
atggccctct ggatgcgcct cctgcccctg ctggccctgc tggccctctg ggcgcccgcg       60

cccacccgag ccttcgttaa ccagcacctg tgtggctccc acctggtaga ggctctgtac      120

ctggtgtgcg gggagcgcgg cttcttctac acgcctaagg cccgccggga ggtggaggac      180

ctgcaggtga gggacgtgga gctggccggg gcgcctggcg agggcggcct gcagcccctg      240

gccctggagg gggccctgca gaagcgaggc atcgtggagc agtgctgcac cagcatctgc      300

tccctctacc agctggagaa ttactgcaac tag                                   333


<210>  7
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-122a

<400>  7
caaacaccat tgtcacactc ca                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-1

<400>  8
ttacatactt ctttacattc ca                                                22


<210>  9
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-152

<400>  9
ccaagttctg tcatgcactg a                                                 21


<210>  10
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-199a-5p

<400>  10
gaacaggtag tctgaacact ggg                                               23


<210>  11
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-199a-3p

<400>  11
taaccaatgt gcagactact gt                                                22


<210>  12
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-215

<400>  12
gtctgtcaat tcataggtca t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-192

<400>  13
ggctgtcaat tcataggtca g                                                 21


<210>  14
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-148a

<400>  14
acaaagttct gtagtgcact ga                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-194

<400>  15
tccacatgga gttgctgtta ca                                                22


<210>  16
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-133a

<400>  16
cagctggttg aaggggacca aa                                                22


<210>  17
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-206

<400>  17
ccacacactt ccttacattc ca                                                22


<210>  18
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-208a-5p

<400>  18
gtataacccg ggccaaaagc tc                                                22


<210>  19
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-208a-3p

<400>  19
acaagctttt tgctcgtctt at                                                22


<210>  20
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-499-5p

<400>  20
aaacatcact gcaagtctta a                                                 21


<210>  21
<211>  133
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric intron composed of introns from human beta-globin and 
       immunoglobulin heavy chain genes

<400>  21
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  22
<211>  1671
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CAG promoter

<400>  22
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gttgccttcg ccccgtgccc cgctccgcgc cgcctcgcgc cgcccgcccc      720

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      780

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc      840

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt      900

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg      960

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1020

gtgccccgcg gtgcgggggg ctgcgagggg aacaaaggct gcgtgcgggg tgtgtgcgtg     1080

ggggggtgag cagggggtgt gggcgcgtcg gtcgggctgc aaccccccct gcacccccct     1140

ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc tccgtacggg gcgtggcgcg     1200

gggctcgccg tgccgggcgg ggggtggcgg caggtggggg tgccgggcgg ggcggggccg     1260

cctcgggccg gggagggctc gggggagggg cgcggcggcc cccggagcgc cggcggctgt     1320

cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat cgtgcgagag ggcgcaggga     1380

cttcctttgt cccaaatctg tgcggagccg aaatctggga ggcgccgccg caccccctct     1440

agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc ctcggggctg tccgcggggg     1560

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc     1620

ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca g              1671


<210>  23
<211>  212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV promoter

<400>  23
gtgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctgcgatcgc ccgccccgtt gacgcaaatg ggcggtaggc      180

gtgtacggtg ggaggtctat ataagcagag ct                                    212


<210>  24
<211>  380
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV enhancer

<400>  24
ggcattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  25
<211>  411
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mini-CMV promoter

<400>  25
tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc       60

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      120

tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc      180

acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa      240

tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag      300

gcgtgtacgg tgggaggtct atataagcag agctctctgg ctaactagag aacccactgc      360

ttaactggct tatcgaaatt aatacgactc actataggga gacccaagct t               411


<210>  26
<211>  1178
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EF1alpha promoter

<400>  26
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccactg gctgcagtac gtgattcttg atcccgagct tcgggttgga agtgggtggg      360

agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt gaggcctggc      420

ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt      480

tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc      540

aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt tttggggccg      600

cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag      660

cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg      720

gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag      780

ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca aaatggagga      840

cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt      900

cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg cacctcgatt      960

agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg     1020

agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat     1080

tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag     1140

tggttcaaag tttttttctt ccatttcagg tgtcgtga                             1178


<210>  27
<211>  623
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RSV promoter

<400>  27
catgtttgac agcttatcat cgcagatccg tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat tcgcgtatct      240

gaggggacta gggtgtgttt aggcgaaaag cggggcttcg gttgtacgcg gttaggagtc      300

ccctcaggat atagtagttt cgcttttgca tagggagggg gaaatgtagt cttatgcaat      360

actcttgtag tcttgcaaca tggtaacgat gagttagcaa catgccttac aaggagagaa      420

aaagcaccgt gcatgccgat tggtggaagt aaggtggtac gatcgtgcct tattaggaag      480

gcaacagacg ggtctgacat ggattggacg aaccactaaa ttccgcattg cagagatatt      540

gtatttaagt gcctagctcg atacaataaa cgccatttga ccattcacca cattggtgtg      600

cacctccaag ctgggtacca gct                                              623


<210>  28
<211>  448
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synapsin 1 promoter

<400>  28
ctgcgctctc aggcacgaca cgactcctcc gctgcccacc gcagactgag gcagcgctga       60

gtcgccggcg ccgcagcgca gatggtcgcg cccgtgcccc cctatctcgc gcctcgcgtg      120

gtgcggtccg gctgggccgg cggcggcgcg gacgcgacca aggtggccgg gaaggggagt      180

ttgcggggga ccggcgagtg acgtcagcgc gccttcagtg ctgaggcggc ggtggcgcgc      240

gccgccaggc gggggcgaag gcactgtccg cggtgctgaa gctggcagtg cgcacgcgcc      300

tcgccgcatc ctgtttcccc tccccctctc tgatagggga tgcgcaattt ggggaatggg      360

ggttgggtgc ttgtccagtg ggtcggggtc ggtcgtcagg taggcacccc caccccgcct      420

catcctggtc ctaaaaccca cttgcact                                         448


<210>  29
<211>  1296
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Calcium/calmodulin-dependent protein kinase II (CaMKII) promoter

<400>  29
taacattatg gccttaggtc acttcatctc catggggttc ttcttctgat tttctagaaa       60

atgagatggg ggtgcagaga gcttcctcag tgacctgccc agggtcacat cagaaatgtc      120

agagctagaa cttgaactca gattactaat cttaaattcc atgccttggg ggcatgcaag      180

tacgatatac agaaggagtg aactcattag ggcagatgac caatgagttt aggaaagaag      240

agtccagggc agggtacatc tacaccaccc gcccagccct gggtgagtcc agccacgttc      300

acctcattat agttgcctct ctccagtcct accttgacgg gaagcacaag cagaaactgg      360

gacaggagcc ccaggagacc aaatcttcat ggtccctctg ggaggatggg tggggagagc      420

tgtggcagag gcctcaggag gggccctgct gctcagtggt gacagatagg ggtgagaaag      480

cagacagagt cattccgtca gcattctggg tctgtttggt acttcttctc acgctaaggt      540

ggcggtgtga tatgcacaat ggctaaaaag cagggagagc tggaaagaaa caaggacaga      600

gacagaggcc aagtcaacca gaccaattcc cagaggaagc aaagaaacca ttacagagac      660

tacaaggggg aagggaagga gagatgaatt agcttcccct gtaaacctta gaacccagct      720

gttgccaggg caacggggca atacctgtct cttcagagga gatgaagttg ccagggtaac      780

tacatcctgt ctttctcaag gaccatccca gaatgtggca cccactagcc gttaccatag      840

caactgcctc tttgccccac ttaatcccat cccgtctgtt aaaagggccc tatagttgga      900

ggtgggggag gtaggaagag cgatgatcac ttgtggacta agtttgttcg catccccttc      960

tccaaccccc tcagtacatc accctggggg aacagggtcc acttgctcct gggcccacac     1020

agtcctgcag tattgtgtat ataaggccag ggcaaagagg agcaggtttt aaagtgaaag     1080

gcaggcaggt gttggggagg cagttaccgg ggcaacggga acagggcgtt tcggaggtgg     1140

ttgccatggg gacctggatg ctgacgaagg ctcgcgaggc tgtgagcagc cacagtgccc     1200

tgctcagaag ccccaagctc gtcagtcaag ccggttctcc gtttgcactc aggagcacgg     1260

gcaggcgagt ggcccctagt tctgggggca gcgggg                               1296


<210>  30
<211>  706
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Glial fibrillary acidic protein (GFAP) promoter

<400>  30
cgcgtgatct aacatatcct ggtgtggagt aggggacgct gctctgacag aggctcgggg       60

gcctgagctg gctctgtgag ctggggagga ggcagacagc caggccttgt ctgcaagcag      120

acctggcagc attgggctgg ccgcccccca gggcctcctc ttcatgccca gtgaatgact      180

caccttggca cagacacaat gttcggggtg ggcacagtgc ctgcttcccg ccgcacccca      240

gcccccctca aatgccttcc gagaagccca ttgagcaggg ggcttgcatt gcaccccagc      300

ctgacagcct ggcatcttgg gataaaagca gcacagcccc ctaggggctg cccttgctgt      360

gtggcgccac cggcggtgga gaacaaggct ctattcagcc tgtgcccagg aaaggggatc      420

aggggatgcc caggcatgga cagtgggtgg caggggggga gaggagggct gtctgcttcc      480

cagaagtcca aggacacaaa tgggtgaggg gagagctctc cccatagctg ggctgcggcc      540

caaccccacc ccctcaggct atgccagggg gtgttgccag gggcacccgg gcatcgccag      600

tctagcccac tccttcataa agccctcgca tcccaggagc gagcagagcc agagcaggtt      660

ggagaggaga cgcatcacct ccgctgctcg cggggtctag agtcga                     706


<210>  31
<211>  1153
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nestin promoter

<400>  31
gaaggcagcc cccggaggtc aaaggctggg cacgcgggag gagaggccag agtcagaggc       60

tgcgggtatc tcagatatga aggaaagatg agagaggctc aggaagaggt aagaaaagac      120

acaagagacc agagaaggga gaagaattag agagggaggc agaggaccgc tgtctctaca      180

gacatagctg gtagagactg ggaggaaggg atgaaccctg agcgcatgaa gggaaggagg      240

tggctggtgg tatatggagg atgtagctgg gccagggaaa agatcctgca ctaaaaatct      300

gaagctaaaa ataacaggac acggggtgga gaggcgaaag gagggcagat tgaggcagag      360

agactgagag gcctggggat gtgggcattc cggtagggca cacagttcac ttgtcttctc      420

tttttccagg aggccaaaga tgctgacctc aagaactcat aataccccag tggggaccac      480

cgcattcata gccctgttac aagaagtggg agatgttcct ttttgtccca gactggaaat      540

ccattacatc ccgaggctca ggttctgtgg tggtcatctc tgtgtggctt gttctgtggg      600

cctacctaaa gtcctaagca cagctctcaa gcagatccga ggcgactaag atgctagtag      660

gggttgtctg gagagaagag ccgaggaggt gggctgtgat ggatcagttc agctttcaaa      720

taaaaaggcg tttttatatt ctgtgtcgag ttcgtgaacc cctgtggtgg gcttctccat      780

ctgtctgggt tagtacctgc cactatactg gaataaggag acgcctgctt ccctcgagtt      840

ggctggacaa ggttatgagc atccgtgtac ttatggggtt gccagcttgg tcctggatcg      900

cccgggccct tcccccaccc gttcggttcc ccaccaccac ccgcgctcgt acgtgcgtct      960

ccgcctgcag ctcttgactc atcggggccc ccgggtcaca tgcgctcgct cggctctata     1020

ggcgccgccc cctgcccacc ccccgcccgc gctgggagcc gcagccgccg ccactcctgc     1080

tctctctgcg ccgccgccgt caccaccgcc accgccaccg gctgagtctg cagtcctccg     1140

aaacgggccc tct                                                        1153


<210>  32
<211>  438
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homeobox Protein 9 (HB9) promoter

<400>  32
tgaataaatt taagcaggct aattaatata taaactagct caatttgtca agttgatttg       60

tattttagtt aattgtgaaa gtaattacca catggtcaaa ttaacagctt tctggaaatg      120

accaagcctg aggttttatt tccttcctgg gtgaagaaaa ttcatttttc caagctcttg      180

atgtgatgaa taaaagtcat aaatctgggt gattggtgca ggcagagtct aaatggcttc      240

atatttcatt ttaggtttaa tagaaatatt catgctctgt tttaatgaaa ttaaattgaa      300

gggggatggg gctagagtgg ttagctgatg aattgacaaa aactaatcag ctttattggg      360

aaacaggttt aagggcacgg acgtgtcaat aacgctcagc ctgaccccct cttccattag      420

ctaggcaggc tgattaga                                                    438


<210>  33
<211>  3015
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tyrosine hydroxylase (TH) promoter

<400>  33
ctgctagggg ctgcttccca gctactcctc ttggctccgt ggcttgcctt ccagcctgtg       60

tgctgtctgg agagccttta aagcctcact tccaccaact agaagtctct ccccaaccct      120

gccctgacct caagtgcacc tcttcaaagt caggtttagc agctgcagct gggggccctg      180

aatcccaccc ctgctgtctt ccttgaagac agaagtgttg ggagctgagg atctgggcta      240

gagactggct gtatgatcca gagaagtagt gtgcttctgg gcctcagatt tcccttctgt      300

agaacaggtt tgtctgaaat ggagaggttg gtgctcctct gcagggccta gtgggagtca      360

ccatgagtgg ttaaaagatc cagcttgtct tttggtgagc tttgagagga ggtaacaggg      420

ctgagttctg gaagcctgac caagggcaga cttaaggggc ctcttggagt tgttctcatc      480

aaatggggat gggacacagc taaagtgccc agggcttctc tgtgcccaca gatgctttag      540

atcttggcac agtgtggtct accagctgtc tctctctgtg tatatatatg tatttcatag      600

acagtgtaca gtggcctggt ttgtgctatc aggctggata tggacagagg caagagtttg      660

tggcagcagt tatctcccaa gagagtccaa agacatcatg ttttcaagtt taggccaggt      720

gctacttgag agagctcaga cacagacaaa ggtctggaga gcacatgtcc tccaccccca      780

cctagcttct gttgcaagca cctccagccg agacaagaga acgaattaaa aagcaatatt      840

tgtgtcagtg taagacattt gccgaaaggt taaatccaca ttcgtgttgc tgcagagcag      900

ccccctatgc aggatttgtt agatacagct ccgtcctacc ctgtgccagc tgagcaaacg      960

ccaggctggg tggggtggaa cccagcctgg gtttgcctca ccctgcaatc cccccagcac     1020

cctctaaagg aggaccctgt ggtgggcatg cagacctagg gactgggcat agataacctt     1080

tgggtttggg caacagcccc cactcctcag gattgaaggc taaggtgcag ccagctctgc     1140

cttcatggtg ggaatgtctc cacgtgaccc ctttctgggc tgtggagaac actcagagaa     1200

gagtcctggg atgccaggca ggccagggat gtgctgggca tgttgagaca ggagtgggct     1260

aagccagcag agttgctgac ccaggaagag ttcagaaagg ggcatggaac atggggaggg     1320

gtccatagtg agagagagca ggcagtgcag agtaaatagt ccctgagctg ggggttatgg     1380

gatttgcagg agcttgctca gagaaggcag aggagagatg ctgcgccaag ctgggtatca     1440

cagagcctca gactcctgga acaggaactg tgggggtcag gtcagcaggg gaggttaggg     1500

agtgttccct ttgtactgac ttagcattta tcctgcttct aggggggaag gggggccagt     1560

gggggatgca cagcaaggca gtgatgtggc aggcagcctg cgggagctcc tggttcctgg     1620

tgtgaaaaag ctgggaagga agagggctgg gtctggtaag tacagcaggc agttggctcc     1680

tgagagtcca agccctgtct agagggtgga gtgagatttc agagggagag ctaaacgggg     1740

tgggggctgg ggagtccagg cttctggctc ctgctaatac tcagtgtgct gggtcctcag     1800

aacctcaggg tggccatttt cagggtgaga gctctgtcct ttggcacttc tgcagactcc     1860

agtatccaga ggaataaaga tggtactctt cctcagttcc cttagtgaga ggacaccttt     1920

ctctgaaggg cttgggcagt tgtcctgaac cattgcctga aggaaggact tgactccagg     1980

gacatagaat gggctcagca taagtcccct gtagtagaga aaggtcccct ctctggtctc     2040

cttagagatc ctgtttcctt ggctgaggaa gctagggtgg atctttgtgt aagtgggtgt     2100

ggatgctcac tggaaatcaa aaggcccctt ggtgttagac cttggggtgc catgggagag     2160

ttgatcactg agtgcgccct tacatggggg ccagctgaga atggggctgc ctctagctcg     2220

agaccatgat gcagggagtg agtgggggag ttcaggatac tcttaactaa agcagaggtc     2280

tgtcccccca gggaggggag gtcagaagac cctagggaga tgccaaaggc tagggttggc     2340

accatgttgc aggctgtgtc ttcaaggaga tgataatcag aggaatcgaa cctgcaaaag     2400

tgggccagtc ttagatacac tatagaggaa taatcttctg aaacattctg tgtctcatag     2460

gacctgcctg aggacccagc cccagtgcca gcacatacac tggggcagtg agtagatagt     2520

atactttgtt acatgggctg gggggacatg gcctgtgccc tggaggggac ttgaagacat     2580

ccaaaaagct agtgagaggg ctcctagatt tatttgtctc caagggctat atatagcctt     2640

cctaacatga acccttgggt aatccagcat gggcgctccc atatgccctg gtttgattag     2700

agagctctag atgtctcctg tcccagaaca ccagccagcc cctgtcttca tgtcgtgtct     2760

agggcggagg gtgattcaga ggcaggtgcc tgcgacagtg gatgcaatta gatctaatgg     2820

gacggaggcc tctctcgtcc gtcgccctcg ctctgtgccc acccccgcct ccctcaggca     2880

cagcaggcgt ggagaggatg cgcaggaggt aggaggtggg ggacccagag gggctttgac     2940

gtcagcctgg cctttaagag gccgcctgcc tggcaagggc cgtggagaca gaactcggga     3000

ccaccagctt gcact                                                      3015


<210>  34
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Myelin basic protein (MBP) promoter

<400>  34
caccgtggct ttaacactta gagaaaatgc atcccctcta atcaataagt catcgacagt       60

gggtagatgg aggaacggca gtgcgtagta ggatgcgtgc aagcatagtc tcgtgcatgg      120

gtgcatagat cgctgggcag gtggacaagg tgggggtgga taaagaagtg ggtagatgat      180

tgatgttagg taaatatcac tgggtggaca gatgggtggt aggtggatgg atggttagaa      240

tagtcagaag agggatggat tgataaggtg aacagatgat aaatgggtga tagactggaa      300

gggttgtcaa aagaggataa gggaagtgtg agctagccgt atttctaagg tcagtaatag      360

agttgggaga agaggttaag ttacatccat ttaaacctca cacgaagctg agagggaatg      420

gacttgctgc cgttggtgag gaaagcgttg catttcccgt gtgcttggtt gtgaagtgct      480

caggtcccac atgaagcagt caggttactg cggcttacag aggagccaga tccaaatgcc      540

ccgagtaagc acgtccccga gccagaggcc tccagcggaa tccgggagag ggattgctca      600

gtgccctgct tccctggact gtaagctgca gaaagatgtg ggaagtcctg ttctccactg      660

agaacactaa aagcaccttt tgtcaaacga ccgcttcaca tctggggctt gtgcactggt      720

ggccttttaa accagagaca acccacaaga tacctaacct gcggggctct ctggtacagt      780

gagcaactca ggaaatgctt tggcttgatt gctgtgggct ctcaggccat cgccctctgg      840

agtggttctt ttaatgagaa cctgaagatt ggcccctgag ccatgtatac caagcaagct      900

caatccaggt tagctccctc tggttggggc aagctaacgt gctccttggg ccccgcgcgt      960

aactgtgcgt tttataggag acagctagtt caagacccca ggaagaaagc ggctttgtcc     1020

ccctctaggc ctcgtacagg cccacattca tatctcattg ttgttgcagg ggaggcagat     1080

gcgatccaga acaatgggac ctcggctgag gacacggcgg tgacagactc caagcacaca     1140

gcagacccaa agaataactg gcaaggcgcc cacccagctg acccagggaa ccgcccccac     1200

ttgatccgcc tcttttcccg agatgccccg ggaagggagg acaacacctt caaagacagg     1260

ccctcagagt ccgacgagct tcagaccatc caagaagatc ccacagcagc ttccgaagaa     1320

ttctgcagtc gacggtaccg cgggcccggg atc                                  1353


<210>  35
<211>  128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Truncated AAV2 5' ITR

<400>  35
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttcct                                                               128


<210>  36
<211>  128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Truncated AAV2 3' ITR

<400>  36
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgc                                                               128


<210>  37
<211>  122
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SV40 polyadenylation signal

<400>  37
taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta       60

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      120

tt                                                                     122


<210>  38
<211>  449
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rabbit beta-globin polyadenylation signal

<400>  38
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga gtatttggtt      180

tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg gctataaaga      240

ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag aaaagccttg      300

acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt aacatcccta      360

aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact actcccagtc      420

atagctgtcc ctcttctctt atggagatc                                        449


<210>  39
<211>  592
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV promoter and CMV enhancer sequence

<400>  39
ggcattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctgcgatcgc ccgccccgtt      540

gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ct              592


<210>  40
<211>  7008
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CAG-hIns-dmiRT

<400>  40
agtgagcgag cgagcgcgca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt       60

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg      120

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg      180

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag      240

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga      300

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct      360

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc      420

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg      480

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc      540

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca      600

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag      660

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct      720

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc      780

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga      840

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca      900

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat      960

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     1020

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     1080

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     1140

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     1200

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     1260

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     1320

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     1380

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     1440

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     1500

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     1560

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     1620

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     1680

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     1740

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     1800

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     1860

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     1920

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     1980

cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta     2040

acctataaaa ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt     2100

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2160

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt     2220

aactatgcgg catcagagca gattgtactg agagtgcacc atatgcggtg tgaaataccg     2280

cacagatgcg taaggagaaa ataccgcatc aggcgattcc aacatccaat aaatcataca     2340

ggcaaggcaa agaattagca aaattaagca ataaagcctc agagcataaa gctaaatcgg     2400

ttgtaccaaa aacattatga ccctgtaata cttttgcggg agaagccttt atttcaacgc     2460

aaggataaaa atttttagaa ccctcatata ttttaaatgc aatgcctgag taatgtgtag     2520

gtaaagattc aaacgggtga gaaaggccgg agacagtcaa atcaccatca atatgatatt     2580

caaccgttct agctgataaa ttcatgccgg agagggtagc tatttttgag aggtctctac     2640

aaaggctatc aggtcattgc ctgagagtct ggagcaaaca agagaatcga tgaacggtaa     2700

tcgtaaaact agcatgtcaa tcatatgtac cccggttgat aatcagaaaa gccccaaaaa     2760

caggaagatt gtataagcaa atatttaaat tgtaagcgtt aatattttgt taaaattcgc     2820

gttaaatttt tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc     2880

ttataaatca aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag     2940

tccactatta aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga     3000

tggcccacta cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc     3060

actaaatcgg aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa     3120

cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt     3180

agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc     3240

gtactatggt tgctttgacg agcacgtata acgtgctttc ctcgttagaa tcagagcggg     3300

agctaaacag gaggccgatt aaagggattt tagacaggaa cggtacgcca gaatcctgag     3360

aagtgttttt ataatcagtg aggccaccga gtaaaagagt ctgtccatca cgcaaattaa     3420

ccgttgtcgc aatacttctt tgattagtaa taacatcact tgcctgagta gaagaactca     3480

aactatcggc cttgctggta atatccagaa caatattacc gccagccatt gcaacggaat     3540

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcc     3600

actgaggccc agctgcgcgc tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt     3660

cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc     3720

aactccatca ctaggggttc cttgtagtta atgattaacc cgccatgcta cttatctact     3780

cgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc     3840

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc     3900

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg     3960

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat     4020

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc     4080

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta     4140

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc     4200

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg     4260

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg     4320

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt     4380

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg     4440

ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg ccgcctcgcg ccgcccgccc     4500

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg     4560

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc     4620

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg     4680

tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc     4740

gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc     4800

ggtgccccgc ggtgcggggg gctgcgaggg gaacaaaggc tgcgtgcggg gtgtgtgcgt     4860

gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc tgcacccccc     4920

tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg ggcgtggcgc     4980

ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg gggcggggcc     5040

gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg ccggcggctg     5100

tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga gggcgcaggg     5160

acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc gcaccccctc     5220

tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg gggagggcct     5280

tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct gtccgcgggg     5340

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg     5400

cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg     5460

caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattgatta attcgagcga     5520

acgcgtcgag tcgctcggta cgatttaaat tgaattggcc tcgagcgcaa gcttgagcta     5580

ggaccttctg ccatggccct gtggatgcgc ctcctgcccc tgctggcgct gctggccctc     5640

tggggacctg acccagccgc agcctttgtg aaccaacacc tgtgcggctc agatctggtg     5700

gaagctctct acctagtgtg cggggaacga ggcttcttct acacacccag gaccaagcgg     5760

gaggcagagg acctgcaggt ggggcaggtg gagctgggcg ggggccctgg tgcaggcagc     5820

ctgcagccct tggccctgga ggggtcgcga cagaagcgtg gcattgtgga acaatgctgt     5880

accagcatct gctccctcta ccagctggag aactactgca actagacgca gccgtcggcc     5940

gctaattcta gatcgcgaac aaacaccatt gtcacactcc agtatacaca aacaccattg     6000

tcacactcca gatatcacaa acaccattgt cacactccaa ggcgaacaaa caccattgtc     6060

acactccaag gctattctag atcgcgaatt acatacttct ttacattcca gtatacatta     6120

catacttctt tacattccag atatcattac atacttcttt acattccaag gcgaattaca     6180

tacttcttta cattccaagg ctacctgagg cccgggggta cctcttaatt aactggcctc     6240

atgggccttc cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agtcaggtgc     6300

aggctgccta tcagaaggtg gtggctggtg tggccaatgc cctggctcac aaataccact     6360

gagatctttt tccctctgcc aaaaattatg gggacatcat gaagcccctt gagcatctga     6420

cttctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc     6480

tctcactcgg aaggacatat gggagggcaa atcatttaaa acatcagaat gagtatttgg     6540

tttagagttt ggcaacatat gcccatatgc tggctgccat gaacaaaggt tggctataaa     6600

gaggtcatca gtatatgaaa cagccccctg ctgtccattc cttattccat agaaaagcct     6660

tgacttgagg ttagattttt tttatatttt gttttgtgtt atttttttct ttaacatccc     6720

taaaattttc cttacatgtt ttactagcca gatttttcct cctctcctga ctactcccag     6780

tcatagctgt ccctcttctc ttatggagat ccctcgacct gcagcccaag ctgtagataa     6840

gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc     6900

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     6960

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc tggcgtaa                  7008


<210>  41
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H. sapiens insulin with furin cleavage sites

<400>  41

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Arg Thr Lys Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Arg Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  42
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  H. sapiens insulin mutant His-B10-Asp with furin cleavage sites

<400>  42

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser Asp Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Arg Thr Lys Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Arg Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  43
<211>  110
<212>  PRT
<213>  Rattus norvegicus

<400>  43

Met Ala Leu Trp Ile Arg Phe Leu Pro Leu Leu Ala Leu Leu Ile Leu 
1               5                   10                  15      


Trp Glu Pro Arg Pro Ala Gln Ala Phe Val Lys Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Met Ser Arg Arg Glu Val Glu Asp Pro Gln Val Ala 
    50                  55                  60                  


Gln Leu Glu Leu Gly Gly Gly Pro Gly Ala Gly Asp Leu Gln Thr Leu 
65                  70                  75                  80  


Ala Leu Glu Val Ala Arg Gln Lys Arg Gly Ile Val Asp Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  44
<211>  110
<212>  PRT
<213>  Pan troglodytes

<400>  44

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Val Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ser Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210>  45
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H. sapiens insulin with furin cleavage sites

<400>  45
atggccctgt ggatgcgcct cctgcccctg ctggcgctgc tggccctctg gggacctgac       60

ccagccgcag cctttgtgaa ccaacacctg tgcggctcac acctggtgga agctctctac      120

ctagtgtgcg gggaacgagg cttcttctac acacccagga ccaagcggga ggcagaggac      180

ctgcaggtgg ggcaggtgga gctgggcggg ggccctggtg caggcagcct gcagcccttg      240

gccctggagg ggtcgcgaca gaagcgtggc attgtggaac aatgctgtac cagcatctgc      300

tccctctacc agctggagaa ctactgcaac tag                                   333


<210>  46
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  H. sapiens insulin mutant His-B10-Asp with furin cleavage sites

<400>  46
atggccctgt ggatgcgcct cctgcccctg ctggcgctgc tggccctctg gggacctgac       60

ccagccgcag cctttgtgaa ccaacacctg tgcggctcag atctggtgga agctctctac      120

ctagtgtgcg gggaacgagg cttcttctac acacccagga ccaagcggga ggcagaggac      180

ctgcaggtgg ggcaggtgga gctgggcggg ggccctggtg caggcagcct gcagcccttg      240

gccctggagg ggtcgcgaca gaagcgtggc attgtggaac aatgctgtac cagcatctgc      300

tccctctacc agctggagaa ctactgcaac tag                                   333


<210>  47
<211>  333
<212>  DNA
<213>  Rattus norvegicus

<400>  47
atggccctgt ggatccgctt cctgcccctg ctggccctgc tcatcctctg ggagccccgc       60

cctgcccagg cttttgtcaa acagcacctt tgtggttctc acttggtgga agctctctac      120

ctggtgtgtg gggagcgtgg attcttctac acacccatgt cccgccgcga agtggaggac      180

ccacaagtgg cacaactgga gctgggtgga ggcccggggg caggtgacct tcagaccttg      240

gcactggagg tggcccggca gaagcgcggc atcgtggatc agtgctgcac cagcatctgc      300

tctctctacc aactggagaa ctactgcaac tag                                   333


<210>  48
<211>  333
<212>  DNA
<213>  Pan troglodytes

<400>  48
atggccctgt ggatgcgcct cctgcccctg ctggtgctgc tggccctctg gggacctgac       60

ccagcctcgg cctttgtgaa ccaacacctg tgcggctccc acctggtgga agctctctac      120

ctagtgtgcg gggaacgagg cttcttctac acacccaaga cccgccggga ggcagaggac      180

ctgcaggtgg ggcaggtgga gctgggcggg ggccctggtg caggcagcct gcagcccttg      240

gccctggagg ggtccctgca gaagcgtggt atcgtggaac aatgctgtac cagcatctgc      300

tccctctacc agctggagaa ctactgcaac tag                                   333


<210>  49
<211>  6740
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CAG-hInsAsp

<400>  49
agtgagcgag cgagcgcgca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt       60

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg      120

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg      180

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag      240

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga      300

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct      360

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc      420

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg      480

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc      540

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca      600

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag      660

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct      720

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc      780

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga      840

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca      900

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat      960

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     1020

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     1080

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     1140

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     1200

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     1260

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     1320

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     1380

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     1440

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     1500

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     1560

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     1620

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     1680

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     1740

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     1800

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     1860

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     1920

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     1980

cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta     2040

acctataaaa ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt     2100

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2160

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt     2220

aactatgcgg catcagagca gattgtactg agagtgcacc atatgcggtg tgaaataccg     2280

cacagatgcg taaggagaaa ataccgcatc aggcgattcc aacatccaat aaatcataca     2340

ggcaaggcaa agaattagca aaattaagca ataaagcctc agagcataaa gctaaatcgg     2400

ttgtaccaaa aacattatga ccctgtaata cttttgcggg agaagccttt atttcaacgc     2460

aaggataaaa atttttagaa ccctcatata ttttaaatgc aatgcctgag taatgtgtag     2520

gtaaagattc aaacgggtga gaaaggccgg agacagtcaa atcaccatca atatgatatt     2580

caaccgttct agctgataaa ttcatgccgg agagggtagc tatttttgag aggtctctac     2640

aaaggctatc aggtcattgc ctgagagtct ggagcaaaca agagaatcga tgaacggtaa     2700

tcgtaaaact agcatgtcaa tcatatgtac cccggttgat aatcagaaaa gccccaaaaa     2760

caggaagatt gtataagcaa atatttaaat tgtaagcgtt aatattttgt taaaattcgc     2820

gttaaatttt tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc     2880

ttataaatca aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag     2940

tccactatta aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga     3000

tggcccacta cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc     3060

actaaatcgg aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa     3120

cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt     3180

agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc     3240

gtactatggt tgctttgacg agcacgtata acgtgctttc ctcgttagaa tcagagcggg     3300

agctaaacag gaggccgatt aaagggattt tagacaggaa cggtacgcca gaatcctgag     3360

aagtgttttt ataatcagtg aggccaccga gtaaaagagt ctgtccatca cgcaaattaa     3420

ccgttgtcgc aatacttctt tgattagtaa taacatcact tgcctgagta gaagaactca     3480

aactatcggc cttgctggta atatccagaa caatattacc gccagccatt gcaacggaat     3540

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcc     3600

actgaggccc agctgcgcgc tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt     3660

cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc     3720

aactccatca ctaggggttc cttgtagtta atgattaacc cgccatgcta cttatctact     3780

cgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc     3840

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc     3900

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg     3960

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat     4020

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc     4080

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta     4140

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc     4200

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg     4260

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg     4320

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt     4380

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg     4440

ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg ccgcctcgcg ccgcccgccc     4500

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg     4560

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc     4620

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg     4680

tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc     4740

gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc     4800

ggtgccccgc ggtgcggggg gctgcgaggg gaacaaaggc tgcgtgcggg gtgtgtgcgt     4860

gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc tgcacccccc     4920

tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg ggcgtggcgc     4980

ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg gggcggggcc     5040

gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg ccggcggctg     5100

tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga gggcgcaggg     5160

acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc gcaccccctc     5220

tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg gggagggcct     5280

tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct gtccgcgggg     5340

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg     5400

cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg     5460

caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattgatta attcgagcga     5520

acgcgtcgag tcgctcggta cgatttaaat tgaattggcc tcgagcgcaa gcttgagcta     5580

gcgtcgacct tctgccatgg ccctgtggat gcgcctcctg cccctgctgg cgctgctggc     5640

cctctgggga cctgacccag ccgcagcctt tgtgaaccaa cacctgtgcg gctcagatct     5700

ggtggaagct ctctacctag tgtgcgggga acgaggcttc ttctacacac ccaggaccaa     5760

gcgggaggca gaggacctgc aggtggggca ggtggagctg ggcgggggcc ctggtgcagg     5820

cagcctgcag cccttggccc tggaggggtc gcgacagaag cgtggcattg tggaacaatg     5880

ctgtaccagc atctgctccc tctaccagct ggagaactac tgcaactaga cgcagccgtc     5940

gacggtaccc ccgacgcggc ctaactggcc tcatgggcct tccgctcact gcccgctttc     6000

cagtcgggaa acctgtcgtg ccagtcaggt gcaggctgcc tatcagaagg tggtggctgg     6060

tgtggccaat gccctggctc acaaatacca ctgagatctt tttccctctg ccaaaaatta     6120

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     6180

cattgcaata gtgtgttgga attttttgtg tctctcactc ggaaggacat atgggagggc     6240

aaatcattta aaacatcaga atgagtattt ggtttagagt ttggcaacat atgcccatat     6300

gctggctgcc atgaacaaag gttggctata aagaggtcat cagtatatga aacagccccc     6360

tgctgtccat tccttattcc atagaaaagc cttgacttga ggttagattt tttttatatt     6420

ttgttttgtg ttattttttt ctttaacatc cctaaaattt tccttacatg ttttactagc     6480

cagatttttc ctcctctcct gactactccc agtcatagct gtccctcttc tcttatggag     6540

atccctcgac ctgcagccca agctgtagat aagtagcatg gcgggttaat cattaactac     6600

aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     6660

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     6720

cgagcgcgca gctggcgtaa                                                 6740


<210>  50
<211>  6740
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CAG-hInsWt

<400>  50
agtgagcgag cgagcgcgca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt       60

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg      120

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg      180

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag      240

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga      300

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct      360

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc      420

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg      480

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc      540

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca      600

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag      660

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct      720

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc      780

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga      840

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca      900

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat      960

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     1020

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     1080

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     1140

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     1200

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     1260

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     1320

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     1380

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     1440

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     1500

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     1560

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     1620

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     1680

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     1740

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     1800

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     1860

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     1920

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     1980

cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta     2040

acctataaaa ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt     2100

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2160

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt     2220

aactatgcgg catcagagca gattgtactg agagtgcacc atatgcggtg tgaaataccg     2280

cacagatgcg taaggagaaa ataccgcatc aggcgattcc aacatccaat aaatcataca     2340

ggcaaggcaa agaattagca aaattaagca ataaagcctc agagcataaa gctaaatcgg     2400

ttgtaccaaa aacattatga ccctgtaata cttttgcggg agaagccttt atttcaacgc     2460

aaggataaaa atttttagaa ccctcatata ttttaaatgc aatgcctgag taatgtgtag     2520

gtaaagattc aaacgggtga gaaaggccgg agacagtcaa atcaccatca atatgatatt     2580

caaccgttct agctgataaa ttcatgccgg agagggtagc tatttttgag aggtctctac     2640

aaaggctatc aggtcattgc ctgagagtct ggagcaaaca agagaatcga tgaacggtaa     2700

tcgtaaaact agcatgtcaa tcatatgtac cccggttgat aatcagaaaa gccccaaaaa     2760

caggaagatt gtataagcaa atatttaaat tgtaagcgtt aatattttgt taaaattcgc     2820

gttaaatttt tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc     2880

ttataaatca aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag     2940

tccactatta aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga     3000

tggcccacta cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc     3060

actaaatcgg aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa     3120

cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt     3180

agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc     3240

gtactatggt tgctttgacg agcacgtata acgtgctttc ctcgttagaa tcagagcggg     3300

agctaaacag gaggccgatt aaagggattt tagacaggaa cggtacgcca gaatcctgag     3360

aagtgttttt ataatcagtg aggccaccga gtaaaagagt ctgtccatca cgcaaattaa     3420

ccgttgtcgc aatacttctt tgattagtaa taacatcact tgcctgagta gaagaactca     3480

aactatcggc cttgctggta atatccagaa caatattacc gccagccatt gcaacggaat     3540

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcc     3600

actgaggccc agctgcgcgc tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt     3660

cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc     3720

aactccatca ctaggggttc cttgtagtta atgattaacc cgccatgcta cttatctact     3780

cgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc     3840

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc     3900

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg     3960

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat     4020

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc     4080

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta     4140

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc     4200

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg     4260

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg     4320

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt     4380

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg     4440

ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg ccgcctcgcg ccgcccgccc     4500

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg     4560

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc     4620

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg     4680

tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc     4740

gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc     4800

ggtgccccgc ggtgcggggg gctgcgaggg gaacaaaggc tgcgtgcggg gtgtgtgcgt     4860

gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc tgcacccccc     4920

tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg ggcgtggcgc     4980

ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg gggcggggcc     5040

gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg ccggcggctg     5100

tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga gggcgcaggg     5160

acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc gcaccccctc     5220

tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg gggagggcct     5280

tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct gtccgcgggg     5340

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg     5400

cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg     5460

caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattgatta attcgagcga     5520

acgcgtcgag tcgctcggta cgatttaaat tgaattggcc tcgagcgcaa gcttgagcta     5580

gcgtcgaggg gtcgacatgg ccctgtggat gcgcctcctg cccctgctgg cgctgctggc     5640

cctctgggga cctgacccag ccgcagcctt tgtgaaccaa cacctgtgcg gctcacacct     5700

ggtggaagct ctctacctag tgtgcgggga acgaggcttc ttctacacac ccaggaccaa     5760

gcgggaggca gaggacctgc aggtggggca ggtggagctg ggcgggggcc ctggtgcagg     5820

cagcctgcag cccttggccc tggaggggtc gcgacagaag cgtggcattg tggaacaatg     5880

ctgtaccagc atctgctccc tctaccagct ggagaactac tgcaactagg tcgacccctc     5940

gacggtaccc ccgacgcggc ctaactggcc tcatgggcct tccgctcact gcccgctttc     6000

cagtcgggaa acctgtcgtg ccagtcaggt gcaggctgcc tatcagaagg tggtggctgg     6060

tgtggccaat gccctggctc acaaatacca ctgagatctt tttccctctg ccaaaaatta     6120

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     6180

cattgcaata gtgtgttgga attttttgtg tctctcactc ggaaggacat atgggagggc     6240

aaatcattta aaacatcaga atgagtattt ggtttagagt ttggcaacat atgcccatat     6300

gctggctgcc atgaacaaag gttggctata aagaggtcat cagtatatga aacagccccc     6360

tgctgtccat tccttattcc atagaaaagc cttgacttga ggttagattt tttttatatt     6420

ttgttttgtg ttattttttt ctttaacatc cctaaaattt tccttacatg ttttactagc     6480

cagatttttc ctcctctcct gactactccc agtcatagct gtccctcttc tcttatggag     6540

atccctcgac ctgcagccca agctgtagat aagtagcatg gcgggttaat cattaactac     6600

aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     6660

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     6720

cgagcgcgca gctggcgtaa                                                 6740


