                         SEQUENCE LISTING

<110>  Daiichi Sankyo Company, Limited
 
<120>  DOSAGE OF AN ANTIBODY-DRUG CONJUGATE

<130>  098065-0265

<150>  US62/896478
<151>  2019-09-05

<150>  US62/853970
<151>  2019-05-29

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  1
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaggatc       60

tcctgcaagg cttctgggta taccttcaca actgctggaa tgcagtgggt gcaaaagatg      120

ccaggaaagg gtttgaagtg gattggctgg ataaacaccc actctggagt gccaaaatat      180

gcagaagact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcatat      240

ttacagataa gcaacctcaa aaatgaggac acgactacgt atttctgtgc gagatcgggg      300

ttcggtagta gctactggta cttcgatgtc tggggcgcag ggaccgcggt caccgtctcc      360

tca                                                                    363


<210>  2
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  2

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 
            20                  25                  30          


Gly Met Gln Trp Val Gln Lys Met Pro Gly Lys Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Val Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Thr Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Ala Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  327
<212>  DNA
<213>  Mus musculus

<400>  3
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgagt actgctgtag cctggtatca acagaaacca      120

ggacaatctc ctaaactgct gatttactcg gcatcctacc gctacactgg agtccctgat      180

cgcttcactg gcagtggatc tgggacggct ttcactttca ccatcagcag tgtgcaggct      240

gaagacctgg cagtttatta ctgtcagcaa cattatatta ctccgctcac gttcggtgct      300

gggaccaagc tggagctgaa acgggct                                          327


<210>  4
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Ala Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala 
            100                 105                 


<210>  5
<211>  449
<212>  DNA
<213>  Homo sapiens

<400>  5
gcctccggac tctagagcca ccatggtgct gcagacccag gtgttcatct ccctgctgct       60

gtggatctcc ggcgcgtacg gcgatatcgt gatgattaaa cgtacggtgg ccgccccctc      120

cgtgttcatc ttccccccct ccgacgagca gctgaagtcc ggcaccgcct ccgtggtgtg      180

cctgctgaat aacttctacc ccagagaggc caaggtgcag tggaaggtgg acaacgccct      240

gcagtccggg aactcccagg agagcgtgac cgagcaggac agcaaggaca gcacctacag      300

cctgagcagc accctgaccc tgagcaaagc cgactacgag aagcacaagg tgtacgcctg      360

cgaggtgacc caccagggcc tgagctcccc cgtcaccaag agcttcaaca ggggggagtg      420

ttaggggccc gtttaaacgg gggaggcta                                        449


<210>  6
<211>  1132
<212>  DNA
<213>  Homo sapiens

<400>  6
gcctccggac tctagagcca ccatgaaaca cctgtggttc ttcctcctgc tggtggcagc       60

tcccagatgg gtgctgagcc aggtgcaatt gtgcaggcgg ttagctcagc ctccaccaag      120

ggcccaagcg tcttccccct ggcaccctcc tccaagagca cctctggcgg cacagccgcc      180

ctgggctgcc tggtcaagga ctacttcccc gaacccgtga ccgtgagctg gaactcaggc      240

gccctgacca gcggcgtgca caccttcccc gctgtcctgc agtcctcagg actctactcc      300

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      360

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      420

aaaactcaca catgcccacc ctgcccagca cctgaactcc tggggggacc ctcagtcttc      480

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      540

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      600

gtggaggtgc ataatgccaa gacaaagccc cgggaggagc agtacaacag cacgtaccgg      660

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      720

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggc      780

cagccccggg aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac      840

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg      900

gagagcaatg gccagcccga gaacaactac aagaccaccc ctcccgtgct ggactccgac      960

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcagggcaac     1020

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacaccca gaagagcctc     1080

tccctgtctc ccggcaaatg agatatcggg cccgtttaaa cgggggaggc ta             1132


<210>  7
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of heavy chain of chimeric murine-human TINA1
       antibody

<400>  7
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag       60

atccagttgg tgcagtctgg acctgagctg aagaagcctg gagagacagt caggatctcc      120

tgcaaggctt ctgggtatac cttcacaact gctggaatgc agtgggtgca aaagatgcca      180

ggaaagggtt tgaagtggat tggctggata aacacccact ctggagtgcc aaaatatgca      240

gaagacttca agggacggtt tgccttctct ttggaaacct ctgccagcac tgcatattta      300

cagataagca acctcaaaaa tgaggacacg actacgtatt tctgtgcgag atcggggttc      360

ggtagtagct actggtactt cgatgtctgg ggcgcaggga ccgcggtcac cgtcagctca      420

gcctccacca agggcccaag cgtcttcccc ctggcaccct cctccaagag cacctctggc      480

ggcacagccg ccctgggctg cctggtcaag gactacttcc ccgaacccgt gaccgtgagc      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc ccgctgtcct gcagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccctgcccag cacctgaact cctgggggga      780

ccctcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cccgggagga gcagtacaac      960

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag gccagccccg ggaaccacag gtgtacaccc tgcccccatc ccgggaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tggccagccc gagaacaact acaagaccac ccctcccgtg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggca acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacc     1380

cagaagagcc tctccctgtc tcccggcaaa                                      1410


<210>  8
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of heavy chain of chimeric murine-human TINA1
       antibody

<400>  8

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Ala Gly Met Gln Trp Val Gln Lys Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Ile Gly Trp Ile Asn Thr His Ser Gly Val Pro Lys Tyr Ala 
65                  70                  75                  80  


Glu Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Thr Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp 
        115                 120                 125             


Val Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  9
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of light chain of chimeric murine-human TINA1
       antibody

<400>  9
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcgtacggc       60

gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgagt actgctgtag cctggtatca acagaaacca      180

ggacaatctc ctaaactgct gatttactcg gcatcctacc gctacactgg agtccctgat      240

cgcttcactg gcagtggatc tgggacggct ttcactttca ccatcagcag tgtgcaggct      300

gaagacctgg cagtttatta ctgtcagcaa cattatatta ctccgctcac gttcggtgct      360

gggaccaagc tggagctgaa acgggctgtg gccgccccct ccgtgttcat cttccccccc      420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac      480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag      540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                         702


<210>  10
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of light chain of chimeric murine-human TINA1
       antibody

<400>  10

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Ala Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ile Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Ala Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  11
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of heavy chain of humanized TINA1 antibody, 
       type H1

<400>  11
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag       60

gtgcagctgg tgcagtctgg cgccgaagtg aagaaaccag gcgccagcgt gaaggtgtcc      120

tgcaaggcca gcggctacac ctttaccacc gccggcatgc agtgggtgcg ccaggctcct      180

ggacagggcc tggaatggat gggctggatc aacacccaca gcggcgtgcc caaatacgcc      240

gaggacttca agggcagagt gaccatcagc gccgacacca gcacctccac agcctacctg      300

cagctgagca gcctgaagtc cgaggacacc gccgtgtact actgcgccag aagcggcttc      360

ggcagcagct actggtactt cgacgtgtgg ggccagggca ccctcgtgac cgtcagctca      420

gcctccacca agggcccaag cgtcttcccc ctggcaccct cctccaagag cacctctggc      480

ggcacagccg ccctgggctg cctggtcaag gactacttcc ccgaacccgt gaccgtgagc      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc ccgctgtcct gcagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccctgcccag cacctgaact cctgggggga      780

ccctcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cccgggagga gcagtacaac      960

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag gccagccccg ggaaccacag gtgtacaccc tgcccccatc ccgggaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tggccagccc gagaacaact acaagaccac ccctcccgtg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggca acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacc     1380

cagaagagcc tctccctgtc tcccggcaaa                                      1410


<210>  12
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of heavy chain of humanized TINA1 antibody, 
       type H1

<400>  12

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Ala Gly Met Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Thr His Ser Gly Val Pro Lys Tyr Ala 
65                  70                  75                  80  


Glu Asp Phe Lys Gly Arg Val Thr Ile Ser Ala Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  13
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of heavy chain of humanized TINA1 antibody, 
       type H2

<400>  13
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag       60

gtgcagctgg tgcagtctgg cgccgaagtg aagaaaccag gcgccagcgt gaaggtgtcc      120

tgcaaggcca gcggctacac ctttaccacc gccggcatgc agtgggtgcg ccaggctcct      180

ggacagggcc tggaatggat gggctggatc aacacccaca gcggcgtgcc caaatacgcc      240

gaggacttca agggcagagt gaccatcagc ctggacacca gcacctccac cgcctacctg      300

cagctgagca gcctgaagtc cgaggacacc gccgtgtact actgcgccag aagcggcttc      360

ggcagcagct actggtactt cgacgtgtgg ggccagggca ccctcgtgac cgtcagctca      420

gcctccacca agggcccaag cgtcttcccc ctggcaccct cctccaagag cacctctggc      480

ggcacagccg ccctgggctg cctggtcaag gactacttcc ccgaacccgt gaccgtgagc      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc ccgctgtcct gcagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccctgcccag cacctgaact cctgggggga      780

ccctcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cccgggagga gcagtacaac      960

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag gccagccccg ggaaccacag gtgtacaccc tgcccccatc ccgggaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tggccagccc gagaacaact acaagaccac ccctcccgtg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggca acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacc     1380

cagaagagcc tctccctgtc tcccggcaaa                                      1410


<210>  14
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of heavy chain of humanized TINA1 antibody, 
       type H2

<400>  14

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Ala Gly Met Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Thr His Ser Gly Val Pro Lys Tyr Ala 
65                  70                  75                  80  


Glu Asp Phe Lys Gly Arg Val Thr Ile Ser Leu Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  15
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of heavy chain of humanized TINA1 antibody, 
       type H3

<400>  15
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag       60

atccagctgg tgcagtctgg cgccgaagtg aagaaacccg gcgagagcgt gaaggtgtcc      120

tgcaaggcca gcggctacac ctttaccacc gccggcatgc agtgggtgca gcagatgcct      180

ggcaagggcc tggaatggat gggctggatc aacacccaca gcggcgtgcc caaatacgcc      240

gaggacttca agggcagagt gaccttcagc ctggacacca gcacctccac cgcctacctg      300

cagctgagca gcctgaagtc cgaggacacc gccgtgtact actgcgccag aagcggcttc      360

ggcagcagct actggtactt cgacgtgtgg ggccagggca ccctcgtgac cgtcagctca      420

gcctccacca agggcccaag cgtcttcccc ctggcaccct cctccaagag cacctctggc      480

ggcacagccg ccctgggctg cctggtcaag gactacttcc ccgaacccgt gaccgtgagc      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc ccgctgtcct gcagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccctgcccag cacctgaact cctgggggga      780

ccctcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cccgggagga gcagtacaac      960

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag gccagccccg ggaaccacag gtgtacaccc tgcccccatc ccgggaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tggccagccc gagaacaact acaagaccac ccctcccgtg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggca acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacc     1380

cagaagagcc tctccctgtc tcccggcaaa                                      1410


<210>  16
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of heavy chain of humanized TINA1 antibody, 
       type H3

<400>  16

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Thr Ala Gly Met Gln Trp Val Gln Gln Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Thr His Ser Gly Val Pro Lys Tyr Ala 
65                  70                  75                  80  


Glu Asp Phe Lys Gly Arg Val Thr Phe Ser Leu Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  17
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of light chain of humanized TINA1 antibody, 
       type L1

<400>  17
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcgtacggc       60

gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggcga cagagtgacc      120

atcacatgca aggccagcca ggacgtgtcc acagccgtgg cctggtatca gcagaagcct      180

ggcaaggccc ccaagctgct gatctacagc gccagctacc ggtacaccgg cgtgcccagc      240

agattttctg gcagcggctc cggcaccgac ttcaccctga caatcagcag cctgcagccc      300

gaggacttcg ccgtgtacta ctgccagcag cactacatca cccccctgac ctttggccag      360

ggcaccaagc tggaaatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc      420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac      480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag      540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                         702


<210>  18
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of light chain of humanized TINA1 antibody, 
       type L1

<400>  18

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ile Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  19
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of light chain of humanized TINA1 antibody, 
       type L2

<400>  19
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcgtacggc       60

gacatcgtga tgacccagag ccctagcagc ctgagcgcca gcgtgggcga cagagtgacc      120

atcacatgca aggccagcca ggacgtgtcc acagccgtgg cctggtatca gcagaagcct      180

ggcaaggccc ccaagctgct gatctacagc gccagctacc ggtacaccgg cgtgcccagc      240

agattttctg gcagcggctc cggcaccgac ttcaccctga caatcagcag cctgcagccc      300

gaggacttcg ccgtgtacta ctgccagcag cactacatca cccccctgac ctttggccag      360

ggcaccaagc tggaaatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc      420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac      480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag      540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                         702


<210>  20
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of light chain of humanized TINA1 antibody, 
       type L2

<400>  20

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ile Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  21
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of light chain of humanized TINA1 antibody, 
       type L3

<400>  21
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcgtacggc       60

gacatcgtga tgacccagag ccctagcagc ctgagcgcca gcgtgggcga cagagtgacc      120

atcacatgca aggccagcca ggacgtgtcc acagccgtgg cctggtatca gcagaagccc      180

ggcaagcagc ccaagctgct gatctacagc gccagctacc ggtacaccgg cgtgcccagc      240

agattttctg gcagcggctc cggcaccgac ttcaccctga caatcagcag cctgcagccc      300

gaggacttcg ccgtgtacta ctgccagcag cactacatca cccccctgac ctttggccag      360

ggcaccaagc tggaaatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc      420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac      480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag      540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                         702


<210>  22
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of light chain of humanized TINA1 antibody, 
       type L3

<400>  22

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Gln Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ile Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  23
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  23

Thr Ala Gly Met Gln 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  24

Trp Ile Asn Thr His Ser Gly Val Pro Lys Tyr Ala Glu Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  25

Ser Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210>  26
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  26

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  27
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  27

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  28

Gln Gln His Tyr Ile Thr Pro Leu Thr 
1               5                   


<210>  29
<211>  1410
<212>  DNA
<213>  Homo sapiens

<400>  29
atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt gctgagccag       60

gtgcagctgc agcagagcgg cagcgagctg aagaagcctg gcgccagcgt caaggtgtcc      120

tgcaaggcca gcggctacac cttcaccaac tacggcatga actgggtgaa gcaggcccca      180

ggccagggcc tgaagtggat gggctggatc aacacctaca ccggcgagcc cacctacacc      240

gacgacttca agggccggtt cgccttcagc ctggacacca gcgtgagcac cgcctacctg      300

cagatcagca gcctgaaggc cgacgatacc gccgtgtact tctgcgccag aggcggcttc      360

ggcagcagct actggtactt cgacgtgtgg ggccagggca gcctggtgac cgtgagctca      420

gcctccacca agggcccaag cgtcttcccc ctggcaccct cctccaagag cacctctggc      480

ggcacagccg ccctgggctg cctggtcaag gactacttcc ccgaacccgt gaccgtgagc      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc ccgctgtcct gcagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      660

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      720

aaatcttgtg acaaaactca cacatgccca ccctgcccag cacctgaact cctgggggga      780

ccctcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cccgggagga gcagtacaac      960

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1020

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1080

aaagccaaag gccagccccg ggaaccacag gtgtacaccc tgcccccatc ccgggaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1200

gccgtggagt gggagagcaa tggccagccc gagaacaact acaagaccac ccctcccgtg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggca acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacc     1380

cagaagagcc tctccctgtc tcccggcaaa                                      1410


<210>  30
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Asp Thr Ser Val Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Asp Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gly Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  31
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  31
atggtgctgc agacccaggt gttcatctcc ctgctgctgt ggatctccgg cgcgtacggc       60

gatatccagc tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgtcc      120

atcacatgca aggccagcca ggacgtgtcc attgccgtgg cctggtatca gcagaagccc      180

ggcaaggccc ccaagctgct gatctacagc gccagctacc ggtacaccgg cgtgcccgac      240

agattcagcg gcagcggctc cggcaccgac ttcaccctga ccatcagcag cctgcagccc      300

gaggacttcg ccgtgtacta ctgccagcag cactacatca cccccctgac cttcggagcc      360

ggcaccaagg tggaaatcaa gcgtacggtg gccgccccct ccgtgttcat cttccccccc      420

tccgacgagc agctgaagtc cggcaccgcc tccgtggtgt gcctgctgaa taacttctac      480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg gaactcccag      540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      600

ctgagcaaag ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      660

ctgagctccc ccgtcaccaa gagcttcaac aggggggagt gt                         702


<210>  32
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Ser Ile Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Ile Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  33
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer mG2aVR2

<400>  33
agagttccag gtcaaggtca ctggctcagg                                        30


<210>  34
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer mKVR2

<400>  34
agtccaactg ttcaggacgc cattttgtcg                                        30


<210>  35
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer 3.3-F1

<400>  35
tataccgtcg acctctagct agagcttggc                                        30


<210>  36
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer 3.3-R1

<400>  36
gctatggcag ggcctgccgc cccgacgttg                                        30


<210>  37
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer TINA1H-F

<400>  37
ccagatgggt gctgagccag atccagttgg tgcagtctgg acctgag                     47


<210>  38
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer TINA1H-R

<400>  38
cttggtggag gctgagctga cggtgaccgc ggtccctgcg ccccagac                    48


<210>  39
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer TINA1L-F

<400>  39
atctccggcg cgtacggcga cattgtgatg acccagtctc acaaattc                    48


<210>  40
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer TINA1L-R

<400>  40
ggagggggcg gccacagccc gtttcagctc cagcttggtc ccagc                       45


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer EG-Inf-F

<400>  41
agctcccaga tgggtgctga gc                                                22


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer EG1-Inf-R

<400>  42
gggcccttgg tggaggctga gc                                                22


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer CM-LKF

<400>  43
ctgtggatct ccggcgcgta cggc                                              24


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of primer KCL-Inf-R

<400>  44
ggagggggcg gccaccgtac g                                                 21


<210>  45
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of anti-TROP2 antibody

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 
            20                  25                  30          


Gly Met Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Val Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  46
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of anti-TROP2 antibody

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


