                               SEQUENCE LISTING

<110> REGENERON PHARMACEUTICALS, INC.
 
<120> STABILIZED FORMULATIONS CONTAINING ANTI-ANGPTL3 ANTIBODIES

<130> 40848.0092WOU1

<140>
<141>

<150> 62/852,643
<151> 2019-05-24

<160> 196   

<170> PatentIn version 3.5

<210> 1
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agttatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatt tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagtggga      300

gctactactt tctactacta ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210> 2
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Ala Thr Thr Phe Tyr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 3
ggattcacct tcagtagtta tggc                                              24


<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 5
atatcatatg atggaagtaa taaa                                              24


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210> 7
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 7
gcgaaagtgg gagctactac tttctactac tactacggta tggacgtc                    48


<210> 8
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Ala Lys Val Gly Ala Thr Thr Phe Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210> 9
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 9
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ttgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaaaag gctaacagtt tcccattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210> 10
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Phe Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Lys Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 11
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 11
cagggtatta gcagctgg                                                     18


<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Gln Gly Ile Ser Ser Trp 
1               5       


<210> 13
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
gctgcatcc                                                                9


<210> 14
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Ala Ala Ser 
1           


<210> 15
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 15
caaaaggcta acagtttccc attcact                                           27


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Gln Lys Ala Asn Ser Phe Pro Phe Thr 
1               5                   


<210> 17
<211> 369
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcaaatg atggaagtaa taaatactat      180

gtagattccg tgaagggccg attcaccatg ggcagagaca attccaagaa cacgctgtat      240

ctccaaatga acagcctgag agttgaggac acggctgtgt attactgtgc gaaaggggct      300

ggaactcttt actactacta ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210> 18
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Asn Asp Gly Ser Asn Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Gly Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Gly Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 19
ggattcacct tcagtagcta tggc                                              24


<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
atatcaaatg atggaagtaa taaa                                              24


<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Ile Ser Asn Asp Gly Ser Asn Lys 
1               5               


<210> 23
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 23
gcgaaagggg ctggaactct ttactactac tactacggta tggacgtc                    48


<210> 24
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Ala Lys Gly Ala Gly Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210> 25
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 25
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaaa cagagtcacc       60

atcacttgcc gggccagtca aagtattagt agctggttgg cctggtatca acaaaaacca      120

gggaaagccc ctaagttcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcaccag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tacaatattt attcgtggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210> 26
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asn Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Ser Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 27
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
caaagtatta gtagctgg                                                     18


<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Gln Ser Ile Ser Ser Trp 
1               5       


<210> 29
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 29
aaggcgtct                                                                9


<210> 30
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Lys Ala Ser 
1           


<210> 31
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
caacagtaca atatttattc gtggacg                                           27


<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Gln Gln Tyr Asn Ile Tyr Ser Trp Thr 
1               5                   


<210> 33
<211> 372
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 33
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg gatggcagtt atatcatttg atagaggtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagggggg      300

ggttcgggga ctttctacta ctactacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210> 34
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Val Ile Ser Phe Asp Arg Gly Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Gly Ser Gly Thr Phe Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 35
ggattcacct tcagtaccta tggc                                              24


<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Gly Phe Thr Phe Ser Thr Tyr Gly 
1               5               


<210> 37
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 37
atatcatttg atagaggtaa taaa                                              24


<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Ile Ser Phe Asp Arg Gly Asn Lys 
1               5               


<210> 39
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 39
gcgaaagggg ggggttcggg gactttctac tactactacg gtatggacgt c                51


<210> 40
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Ala Lys Gly Gly Gly Ser Gly Thr Phe Tyr Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210> 41
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 41
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaaa cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca ccagaaacca      120

gggaaagtcc ctaaggtcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaacagtt tcccattcac tttcggccct      300

gggaccaaag tggatatcaa acga                                             324


<210> 42
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asn Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr His Gln Lys Pro Gly Lys Val Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 43
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 43
cagggtatta gcagctgg                                                     18


<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Gln Gly Ile Ser Ser Trp 
1               5       


<210> 45
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 45
gctgcatcc                                                                9


<210> 46
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Ala Ala Ser 
1           


<210> 47
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 47
caacaggcta acagtttccc attcact                                           27


<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Gln Gln Ala Asn Ser Phe Pro Phe Thr 
1               5                   


<210> 49
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 49
caggtacagc tgcagcagtc aggtccagga ctggtgaaac cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaacagtc ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180

aatgattatg cagtgtctgt gagaggtcga ataaccatca acccagacac atccaataac      240

cagttctccc tacatctgaa ctctgtgact cccgaggaca cggcgatgta ttactgtgca      300

agagacaagg gtctaacagc tcgtccgacc tactttgact actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 50
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Pro Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Arg Gly Arg Ile Thr Ile Asn Pro Asp Thr Ser Asn Asn 
65                  70                  75                  80  


Gln Phe Ser Leu His Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Lys Gly Leu Thr Ala Arg Pro Thr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 51
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 51
ggggacagtg tctctagcaa cagtcctgct                                        30


<210> 52
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Gly Asp Ser Val Ser Ser Asn Ser Pro Ala 
1               5                   10  


<210> 53
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 53
acatactaca ggtccaagtg gtataat                                           27


<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
1               5                   


<210> 55
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 55
gcaagagaca agggtctaac agctcgtccg acctactttg actac                       45


<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Ala Arg Asp Lys Gly Leu Thr Ala Arg Pro Thr Tyr Phe Asp Tyr 
1               5                   10                  15  


<210> 57
<211> 326
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 57
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattaat tactggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagcccct tatctataag gcgtctagtt tagaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagag ttcactctca ccatcagcag cctgcagcct      240

gacgatttta caacttatta ctgccaacag tataatagtt attctccgac gttcggccaa      300

gggaccaagg tggaaatcaa acgaac                                           326


<210> 58
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 58
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Tyr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Thr Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210> 59
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 59
cagagtatta attactgg                                                     18


<210> 60
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Gln Ser Ile Asn Tyr Trp 
1               5       


<210> 61
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 61
aaggcgtct                                                                9


<210> 62
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Lys Ala Ser 
1           


<210> 63
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 63
caacagtata atagttattc tccgacg                                           27


<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Gln Gln Tyr Asn Ser Tyr Ser Pro Thr 
1               5                   


<210> 65
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 65
gaggtgcagc tggtggagtc tgggggaggc gtgatacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcgat gattatgcca tgaactgggt ccgtcaaggt      120

ccagggaagg gtctggagtg ggtctctgcc ataagtggtg atggcggtag cacatactat      180

gcagactcgg tgaagggccg attcaccatc tccagagaca acagcaaaaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac accgcctttt tttactgtgc aaaagatctc      300

cgtaatacga tttttggagt ggttattccc gatgcttttg atatctgggg ccaagggaca      360

atggtcaccg tctcttca                                                    378


<210> 66
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 66
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Phe Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Asn Thr Ile Phe Gly Val Val Ile Pro Asp Ala 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125     


<210> 67
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 67
ggattcacct tcgatgatta tgcc                                              24


<210> 68
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210> 69
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 69
ataagtggtg atggcggtag caca                                              24


<210> 70
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 70
Ile Ser Gly Asp Gly Gly Ser Thr 
1               5               


<210> 71
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 71
gcaaaagatc tccgtaatac gatttttgga gtggttattc ccgatgcttt tgatatc          57


<210> 72
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Ala Lys Asp Leu Arg Asn Thr Ile Phe Gly Val Val Ile Pro Asp Ala 
1               5                   10                  15      


Phe Asp Ile 
            


<210> 73
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 73
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagcattagg agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tataatagtt attcgtacac ttttggccag      300

gggaccaagc tggagatcaa acga                                             324


<210> 74
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 74
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210> 75
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 75
cagagcatta ggagctgg                                                     18


<210> 76
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 76
Gln Ser Ile Arg Ser Trp 
1               5       


<210> 77
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 77
aaggcgtct                                                                9


<210> 78
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 78
Lys Ala Ser 
1           


<210> 79
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 79
caacaatata atagttattc gtacact                                           27


<210> 80
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 80
Gln Gln Tyr Asn Ser Tyr Ser Tyr Thr 
1               5                   


<210> 81
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 81
caggtgcagc tggtggagtc ggggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagt gactactaca tgagctggat ccgtcaggct      120

ccagggaagg ggctggagtg ggtttcatac attggtagta gtggtgtcaa catgtactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ttcattatat      240

ctggaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagagactct      300

tcccaactgg gttttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 82
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 82
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Gly Ser Ser Gly Val Asn Met Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Gln Leu Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 83
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 83
ggattcactt tcagtgacta ctac                                              24


<210> 84
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 84
Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210> 85
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 85
attggtagta gtggtgtcaa catg                                              24


<210> 86
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 86
Ile Gly Ser Ser Gly Val Asn Met 
1               5               


<210> 87
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 87
gcgagagact cttcccaact gggttttgac tac                                    33


<210> 88
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 88
Ala Arg Asp Ser Ser Gln Leu Gly Phe Asp Tyr 
1               5                   10      


<210> 89
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 89
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc ggacaagtca gaatattatc aactttttaa attggtatca acagaaacct      120

gggaaggccc ctaaactcct gatctatact acttccactt tacaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctct ccatcaatag tctacaacct      240

gaagattttg caacttactt ctgtcaacag acttacagta atccactcac tttcggcgga      300

gggaccaagg tggagatcaa acga                                             324


<210> 90
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 90
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asn Ile Ile Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Asn Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210> 91
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 91
cagaatatta tcaacttt                                                     18


<210> 92
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 92
Gln Asn Ile Ile Asn Phe 
1               5       


<210> 93
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 93
actacttcc                                                                9


<210> 94
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 94
Thr Thr Ser 
1           


<210> 95
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 95
caacagactt acagtaatcc actcact                                           27


<210> 96
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 96
Gln Gln Thr Tyr Ser Asn Pro Leu Thr 
1               5                   


<210> 97
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 97
gaggtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt aattatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt gtttggtatg atggagataa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatatt      300

atcacatctc gcccgacttt ggactactgg ggccagggaa ccctggtcac tgtctcctca      360


<210> 98
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 98
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Trp Tyr Asp Gly Asp Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Ile Thr Ser Arg Pro Thr Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 99
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 99
ggattcacct tcagtaatta tggc                                              24


<210> 100
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 100
Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210> 101
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 101
gtttggtatg atggagataa taaa                                              24


<210> 102
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 102
Val Trp Tyr Asp Gly Asp Asn Lys 
1               5               


<210> 103
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 103
gcgagagata ttatcacatc tcgcccgact ttggactac                              39


<210> 104
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 104
Ala Arg Asp Ile Ile Thr Ser Arg Pro Thr Leu Asp Tyr 
1               5                   10              


<210> 105
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 105
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgct gggccagtca gggcattaac agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatcct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gtagattttg caacttatta ctgtcaacag cttaatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acga                                             324


<210> 106
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 106
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Gly Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Pro Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Val Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 107
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 107
cagggcatta acagttat                                                     18


<210> 108
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 108
Gln Gly Ile Asn Ser Tyr 
1               5       


<210> 109
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 109
cctgcatcc                                                                9


<210> 110
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 110
Pro Ala Ser 
1           


<210> 111
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 111
caacagctta atagttaccc gctcact                                           27


<210> 112
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 112
Gln Gln Leu Asn Ser Tyr Pro Leu Thr 
1               5                   


<210> 113
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 113
caggtgcagc tggtggagtc ggggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccata tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagattct      300

tcccaactgg gttttgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 114
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 114
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Gln Leu Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 115
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 115
ggattcacct tcagtgacta ctac                                              24


<210> 116
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 116
Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210> 117
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 117
attagtagta gtggtagtac cata                                              24


<210> 118
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 118
Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210> 119
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 119
gcgagagatt cttcccaact gggttttgac tac                                    33


<210> 120
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 120
Ala Arg Asp Ser Ser Gln Leu Gly Phe Asp Tyr 
1               5                   10      


<210> 121
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 121
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattatc agctttttaa attggtatca gcagaaacca      120

gggaaggccc ctaagctcct gatctatact gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctacaacct      240

gaagattttg caacttacta ctgtcaacag acttacagta atccgctcac tttcggcgga      300

gggaccaagg tggaaatcaa acga                                             324


<210> 122
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 122
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ile Ser Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Asn Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 123
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 123
cagagcatta tcagcttt                                                     18


<210> 124
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 124
Gln Ser Ile Ile Ser Phe 
1               5       


<210> 125
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 125
actgcatcc                                                                9


<210> 126
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 126
Thr Ala Ser 
1           


<210> 127
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 127
caacagactt acagtaatcc gctcact                                           27


<210> 128
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 128
Gln Gln Thr Tyr Ser Asn Pro Leu Thr 
1               5                   


<210> 129
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 129
caggtgcagc tggtacagtc tggacctgag gtgaagaagc ctggggcctc agtgagggtc       60

tcctgtaagg cttctggtta ccttagtgac tttattatca cctgggtgcg acaggcccct      120

ggacaagggc ttgagtggat gggatggatc agcacttaca gtggtgacac agactctgca      180

ccgaagttcc agggcagagt caccatgacc acagacacat ccacgactac agtcttcttg      240

gaactgagga gcctgagatc tgacgacacg gccgtgtatt attgtgcgag agggcggctg      300

tttgactact ggggccaggg aaccctggtc accgtctcct ca                         342


<210> 130
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 130
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Leu Ser Asp Phe Ile 
            20                  25                  30          


Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Ser Thr Tyr Ser Gly Asp Thr Asp Ser Ala Pro Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Val Phe Leu 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210> 131
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 131
ggttacctta gtgactttat t                                                 21


<210> 132
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 132
Gly Tyr Leu Ser Asp Phe Ile 
1               5           


<210> 133
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 133
atcagcactt acagtggtga caca                                              24


<210> 134
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 134
Ile Ser Thr Tyr Ser Gly Asp Thr 
1               5               


<210> 135
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 135
gcgagagggc ggctgtttga ctac                                              24


<210> 136
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 136
Ala Arg Gly Arg Leu Phe Asp Tyr 
1               5               


<210> 137
<211> 339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 137
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcaacaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggccg      300

tacacttttg gccaggggac caagctggag atcaaacga                             339


<210> 138
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 138
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210> 139
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 139
caaagcctcg tatacagtga tggaaacacc tac                                    33


<210> 140
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 140
Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210> 141
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 141
aaggtttct                                                                9


<210> 142
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 142
Lys Val Ser 
1           


<210> 143
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 143
atgcaaggta cacactggcc gtacact                                           27


<210> 144
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 144
Met Gln Gly Thr His Trp Pro Tyr Thr 
1               5                   


<210> 145
<211> 354
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 145
caggtgcagc tggtggagtc tgggggagtc tcggtcaagc ctggagggtc cctgcgactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggcg      120

ccagggaagg gactggagtg ggtttcgtac attggtagta gtggtactaa tgactactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

cttcaaatgg acagcctgag agccgaggac acggccgtct attactgtgc gagagattct      300

tcccaaatgg gttttgacta ctggggccag ggaaccctgg tcactgtctc ctca            354


<210> 146
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 146
Gln Val Gln Leu Val Glu Ser Gly Gly Val Ser Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Gly Ser Ser Gly Thr Asn Asp Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Gln Met Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 147
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 147
ggattcacct tcagtgacta ctac                                              24


<210> 148
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 148
Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210> 149
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 149
attggtagta gtggtactaa tgac                                              24


<210> 150
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 150
Ile Gly Ser Ser Gly Thr Asn Asp 
1               5               


<210> 151
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 151
gcgagagatt cttcccaaat gggttttgac tac                                    33


<210> 152
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 152
Ala Arg Asp Ser Ser Gln Met Gly Phe Asp Tyr 
1               5                   10      


<210> 153
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 153
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctgtgggaga cagagtcacc       60

atcacttgcc gggcaagtca gaacattatc aactttttaa attggtatca gcagagacca      120

gggaaagccc ctcagctcct gatctatgtt gcagccagct tgcagagtgg ggtcccatca      180

aggttcactg gcagtggata tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaggatttcg caacttacta ctgtcaacag acttacacta acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acga                                             324


<210> 154
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 154
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Ile Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ala Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Thr Asn Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 155
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 155
cagaacatta tcaacttt                                                     18


<210> 156
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 156
Gln Asn Ile Ile Asn Phe 
1               5       


<210> 157
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 157
gttgcagcc                                                                9


<210> 158
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 158
Val Ala Ala 
1           


<210> 159
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 159
caacagactt acactaaccc gctcact                                           27


<210> 160
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 160
Gln Gln Thr Tyr Thr Asn Pro Leu Thr 
1               5                   


<210> 161
<211> 460
<212> PRT
<213> Homo sapiens

<400> 161
Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser 
1               5                   10                  15      


Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
    130                 135                 140                 


Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu 
145                 150                 155                 160 


Val Thr Ser Leu Lys Thr Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 
                165                 170                 175     


Asp Leu Leu Gln Thr Val Glu Asp Gln Tyr Lys Gln Leu Asn Gln Gln 
            180                 185                 190         


His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Arg Thr Ser Ile 
        195                 200                 205             


Gln Glu Pro Thr Glu Ile Ser Leu Ser Ser Lys Pro Arg Ala Pro Arg 
    210                 215                 220                 


Thr Thr Pro Phe Leu Gln Leu Asn Glu Ile Arg Asn Val Lys His Asp 
225                 230                 235                 240 


Gly Ile Pro Ala Glu Cys Thr Thr Ile Tyr Asn Arg Gly Glu His Thr 
                245                 250                 255     


Ser Gly Met Tyr Ala Ile Arg Pro Ser Asn Ser Gln Val Phe His Val 
            260                 265                 270         


Tyr Cys Asp Val Ile Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        275                 280                 285             


Ile Asp Gly Ser Gln Asn Phe Asn Glu Thr Trp Glu Asn Tyr Lys Tyr 
    290                 295                 300                 


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
305                 310                 315                 320 


Tyr Ser Ile Val Lys Gln Ser Asn Tyr Val Leu Arg Ile Glu Leu Glu 
                325                 330                 335     


Asp Trp Lys Asp Asn Lys His Tyr Ile Glu Tyr Ser Phe Tyr Leu Gly 
            340                 345                 350         


Asn His Glu Thr Asn Tyr Thr Leu His Leu Val Ala Ile Thr Gly Asn 
        355                 360                 365             


Val Pro Asn Ala Ile Pro Glu Asn Lys Asp Leu Val Phe Ser Thr Trp 
    370                 375                 380                 


Asp His Lys Ala Lys Gly His Phe Asn Cys Pro Glu Gly Tyr Ser Gly 
385                 390                 395                 400 


Gly Trp Trp Trp His Asp Glu Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                405                 410                 415     


Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Leu 
            420                 425                 430         


Ser Trp Lys Ser Gln Asn Gly Arg Leu Tyr Ser Ile Lys Ser Thr Lys 
        435                 440                 445             


Met Leu Ile His Pro Thr Asp Ser Glu Ser Phe Glu 
    450                 455                 460 


<210> 162
<211> 1383
<212> DNA
<213> Homo sapiens

<400> 162
atgttcacaa ttaagctcct tctttttatt gttcctctag ttatttcctc cagaattgat       60

caagacaatt catcatttga ttctctatct ccagagccaa aatcaagatt tgctatgtta      120

gacgatgtaa aaattttagc caatggcctc cttcagttgg gacatggtct taaagacttt      180

gtccataaga cgaagggcca aattaatgac atatttcaaa aactcaacat atttgatcag      240

tctttttatg atctatcgct gcaaaccagt gaaatcaaag aagaagaaaa ggaactgaga      300

agaactacat ataaactaca agtcaaaaat gaagaggtaa agaatatgtc acttgaactc      360

aactcaaaac ttgaaagcct cctagaagaa aaaattctac ttcaacaaaa agtgaaatat      420

ttagaagagc aactaactaa cttaattcaa aatcaacctg aaactccaga acacccagaa      480

gtaacttcac ttaaaacttt tgtagaaaaa caagataata gcatcaaaga ccttctccag      540

accgtggaag accaatataa acaattaaac caacagcata gtcaaataaa agaaatagaa      600

aatcagctca gaaggactag tattcaagaa cccacagaaa tttctctatc ttccaagcca      660

agagcaccaa gaactactcc ctttcttcag ttgaatgaaa taagaaatgt aaaacatgat      720

ggcattcctg ctgaatgtac caccatttat aacagaggtg aacatacaag tggcatgtat      780

gccatcagac ccagcaactc tcaagttttt catgtctact gtgatgttat atcaggtagt      840

ccatggacat taattcaaca tcgaatagat ggatcacaaa acttcaatga aacgtgggag      900

aactacaaat atggttttgg gaggcttgat ggagaatttt ggttgggcct agagaagata      960

tactccatag tgaagcaatc taattatgtt ttacgaattg agttggaaga ctggaaagac     1020

aacaaacatt atattgaata ttctttttac ttgggaaatc acgaaaccaa ctatacgcta     1080

catctagttg cgattactgg caatgtcccc aatgcaatcc cggaaaacaa agatttggtg     1140

ttttctactt gggatcacaa agcaaaagga cacttcaact gtccagaggg ttattcagga     1200

ggctggtggt ggcatgatga gtgtggagaa aacaacctaa atggtaaata taacaaacca     1260

agagcaaaat ctaagccaga gaggagaaga ggattatctt ggaagtctca aaatggaagg     1320

ttatactcta taaaatcaac caaaatgttg atccatccaa cagattcaga aagctttgaa     1380

tga                                                                   1383


<210> 163
<211> 455
<212> PRT
<213> Mus musculus

<400> 163
Met His Thr Ile Lys Leu Phe Leu Phe Val Val Pro Leu Val Ile Ala 
1               5                   10                  15      


Ser Arg Val Asp Pro Asp Leu Ser Ser Phe Asp Ser Ala Pro Ser Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Ser Phe Tyr Asp Leu Ser Leu Arg Thr Asn Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Thr Thr Ser Thr Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Val Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Thr Ala Leu Gln His Lys Val Arg Ala Leu Glu Glu Gln 
    130                 135                 140                 


Leu Thr Asn Leu Ile Leu Ser Pro Ala Gly Ala Gln Glu His Pro Glu 
145                 150                 155                 160 


Val Thr Ser Leu Lys Ser Phe Val Glu Gln Gln Asp Asn Ser Ile Arg 
                165                 170                 175     


Glu Leu Leu Gln Ser Val Glu Glu Gln Tyr Lys Gln Leu Ser Gln Gln 
            180                 185                 190         


His Met Gln Ile Lys Glu Ile Glu Lys Gln Leu Arg Lys Thr Gly Ile 
        195                 200                 205             


Gln Glu Pro Ser Glu Asn Ser Leu Ser Ser Lys Ser Arg Ala Pro Arg 
    210                 215                 220                 


Thr Thr Pro Pro Leu Gln Leu Asn Glu Thr Glu Asn Thr Glu Gln Asp 
225                 230                 235                 240 


Asp Leu Pro Ala Asp Cys Ser Ala Val Tyr Asn Arg Gly Glu His Thr 
                245                 250                 255     


Ser Gly Val Tyr Thr Ile Lys Pro Arg Asn Ser Gln Gly Phe Asn Val 
            260                 265                 270         


Tyr Cys Asp Thr Gln Ser Gly Ser Pro Trp Thr Leu Ile Gln His Arg 
        275                 280                 285             


Lys Asp Gly Ser Gln Asp Phe Asn Glu Thr Trp Glu Asn Tyr Glu Lys 
    290                 295                 300                 


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
305                 310                 315                 320 


Tyr Ala Ile Val Gln Gln Ser Asn Tyr Ile Leu Arg Leu Glu Leu Gln 
                325                 330                 335     


Asp Trp Lys Asp Ser Lys His Tyr Val Glu Tyr Ser Phe His Leu Gly 
            340                 345                 350         


Ser His Glu Thr Asn Tyr Thr Leu His Val Ala Glu Ile Ala Gly Asn 
        355                 360                 365             


Ile Pro Gly Ala Leu Pro Glu His Thr Asp Leu Met Phe Ser Thr Trp 
    370                 375                 380                 


Asn His Arg Ala Lys Gly Gln Leu Tyr Cys Pro Glu Ser Tyr Ser Gly 
385                 390                 395                 400 


Gly Trp Trp Trp Asn Asp Ile Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                405                 410                 415     


Tyr Asn Lys Pro Arg Thr Lys Ser Arg Pro Glu Arg Arg Arg Gly Ile 
            420                 425                 430         


Tyr Trp Arg Pro Gln Ser Arg Lys Leu Tyr Ala Ile Lys Ser Ser Lys 
        435                 440                 445             


Met Met Leu Gln Pro Thr Thr 
    450                 455 


<210> 164
<211> 406
<212> PRT
<213> Homo sapiens

<400> 164
Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu Leu Phe 
            180                 185                 190         


Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro Gln Gly 
        195                 200                 205             


Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Asp Gly Gly Trp 
    210                 215                 220                 


Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn Arg Pro 
225                 230                 235                 240 


Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu Phe Trp 
                245                 250                 255     


Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn Ser Arg 
            260                 265                 270         


Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln 
        275                 280                 285             


Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu 
    290                 295                 300                 


Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro Pro Ser 
305                 310                 315                 320 


Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp Leu Arg 
                325                 330                 335     


Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly 
            340                 345                 350         


Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro 
        355                 360                 365             


Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg 
    370                 375                 380                 


Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln Pro Met 
385                 390                 395                 400 


Ala Ala Glu Ala Ala Ser 
                405     


<210> 165
<211> 386
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 165
Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Leu Ser Pro Glu 
1               5                   10                  15      


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
            20                  25                  30          


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
        35                  40                  45              


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
    50                  55                  60                  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
65                  70                  75                  80  


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
                85                  90                  95      


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
            100                 105                 110         


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
        115                 120                 125             


Leu Thr Asn Leu Ile Gln Asn Gln Pro Glu Thr Pro Glu His Pro Glu 
    130                 135                 140                 


Val Thr Ser Leu Lys Thr Phe Val Glu Glu Pro Arg Gly Pro Thr Ile 
145                 150                 155                 160 


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
                165                 170                 175     


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
            180                 185                 190         


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
        195                 200                 205             


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
    210                 215                 220                 


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
225                 230                 235                 240 


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
                245                 250                 255     


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
            260                 265                 270         


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
        275                 280                 285             


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
    290                 295                 300                 


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
305                 310                 315                 320 


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
                325                 330                 335     


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
            340                 345                 350         


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
        355                 360                 365             


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
    370                 375                 380                 


Gly Lys 
385     


<210> 166
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 166
Gly Ala Pro Ser Arg Val Asp Pro Asp Leu Ser Ser Phe Asp Ser Ala 
1               5                   10                  15      


Pro Ser Glu Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile 
            20                  25                  30          


Leu Ala Asn Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val 
        35                  40                  45              


His Lys Thr Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile 
    50                  55                  60                  


Phe Asp Gln Ser Phe Tyr Asp Leu Ser Leu Arg Thr Asn Glu Ile Lys 
65                  70                  75                  80  


Glu Glu Glu Lys Glu Leu Arg Arg Thr Thr Ser Thr Leu Gln Val Lys 
                85                  90                  95      


Asn Glu Glu Val Lys Asn Met Ser Val Glu Leu Asn Ser Lys Leu Glu 
            100                 105                 110         


Ser Leu Leu Glu Glu Lys Thr Ala Leu Gln His Lys Val Arg Ala Leu 
        115                 120                 125             


Glu Glu Gln Leu Thr Asn Leu Ile Leu Ser Pro Ala Gly Ala Gln Glu 
    130                 135                 140                 


His Pro Glu Val Thr Ser Leu Lys Ser Phe Val Glu Gln Gln Asp Asn 
145                 150                 155                 160 


Ser Ile Arg Glu Leu Leu Gln Ser Val Glu Glu Gln Tyr Lys Gln Leu 
                165                 170                 175     


Ser Gln Gln His Met Gln Ile Lys Glu Ile Glu Lys Gln Leu Arg Lys 
            180                 185                 190         


Thr Gly Ile Gln Glu Pro Ser Glu Asn Ser Leu Ser Ser Lys Ser Arg 
        195                 200                 205             


Ala Pro Arg Thr Thr Pro Pro Leu Gln Leu Asn Glu Thr Glu Asn Thr 
    210                 215                 220                 


Glu Gln Asp Ala Ser His His His His His His 
225                 230                 235 


<210> 167
<211> 182
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 167
Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Val Ser Pro Glu 
1               5                   10                  15      


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
            20                  25                  30          


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
        35                  40                  45              


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
    50                  55                  60                  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
65                  70                  75                  80  


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
                85                  90                  95      


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
            100                 105                 110         


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
        115                 120                 125             


Leu Thr Asn Leu Ile Gln Asn Gln Pro Ala Thr Pro Glu His Pro Glu 
    130                 135                 140                 


Val Thr Ser Leu Lys Ser Phe Val Glu Lys Glu Gln Lys Leu Ile Ser 
145                 150                 155                 160 


Glu Glu Asp Leu Gly Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                165                 170                 175     


His His His His His His 
            180         


<210> 168
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 168
Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu Leu 
1               5                   10                  15      


Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser Gln 
            20                  25                  30          


Leu 
    


<210> 169
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 169
Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn Gly Leu Leu 
1               5                   10                  15      


Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr Lys Gly Gln 
            20                  25                  30          


Ile 
    


<210> 170
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 170
Glu Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala 
1               5                   10                  15      


Asn Gly Leu Leu Gln Leu Gly His Gly Leu 
            20                  25      


<210> 171
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 171
Ala Gly Ser Ser Pro Gly Gly 
1               5           


<210> 172
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 172
Gly Gly Gly Gly Ser 
1               5   


<210> 173
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 173
Gly Pro Ser Ser Gly Ala Pro Pro Pro Lys 
1               5                   10  


<210> 174
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 174
Gly Gly Gly Gly Ser Lys 
1               5       


<210> 175
<211> 455
<212> PRT
<213> Rattus norvegicus

<400> 175
Met His Thr Ile Lys Leu Leu Leu Phe Val Val Pro Leu Val Ile Ser 
1               5                   10                  15      


Ser Arg Val Asp Pro Asp Leu Ser Pro Phe Asp Ser Val Pro Ser Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Cys Phe Tyr Asp Leu Ser Leu Gln Thr Asn Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Thr Thr Ser Lys Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Met Ala Leu Gln His Arg Val Arg Ala Leu Glu Glu Gln 
    130                 135                 140                 


Leu Thr Ser Leu Val Gln Asn Pro Pro Gly Ala Arg Glu His Pro Glu 
145                 150                 155                 160 


Val Thr Ser Leu Lys Ser Phe Val Glu Gln Gln Asp Asn Ser Ile Arg 
                165                 170                 175     


Glu Leu Leu Gln Ser Val Glu Glu Gln Tyr Lys Gln Leu Ser Gln Gln 
            180                 185                 190         


His Ile Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Lys Thr Gly Ile 
        195                 200                 205             


Gln Glu Pro Thr Glu Asn Ser Leu Tyr Ser Lys Pro Arg Ala Pro Arg 
    210                 215                 220                 


Thr Thr Pro Pro Leu His Leu Lys Glu Ala Lys Asn Ile Glu Gln Asp 
225                 230                 235                 240 


Asp Leu Pro Ala Asp Cys Ser Ala Ile Tyr Asn Arg Gly Glu His Thr 
                245                 250                 255     


Ser Gly Val Tyr Thr Ile Arg Pro Ser Ser Ser Gln Val Phe Asn Val 
            260                 265                 270         


Tyr Cys Asp Thr Gln Ser Gly Thr Pro Arg Thr Leu Ile Gln His Arg 
        275                 280                 285             


Lys Asp Gly Ser Gln Asn Phe Asn Gln Thr Trp Glu Asn Tyr Glu Lys 
    290                 295                 300                 


Gly Phe Gly Arg Leu Asp Gly Glu Phe Trp Leu Gly Leu Glu Lys Ile 
305                 310                 315                 320 


Tyr Ala Ile Val Lys Gln Ser Asn Tyr Ile Leu Arg Leu Glu Leu Gln 
                325                 330                 335     


Asp Trp Lys Asp Ser Lys His Tyr Ala Glu Tyr Ser Phe His Leu Gly 
            340                 345                 350         


Asn His Glu Thr Asn Tyr Thr Leu His Val Ala Glu Ile Ala Ala Asn 
        355                 360                 365             


Ile Pro Glu Ala Leu Pro Glu His Arg Asp Leu Met Phe Ser Thr Trp 
    370                 375                 380                 


Asp His Arg Ala Lys Gly Gln Leu Tyr Cys Pro Glu Ser Tyr Ser Gly 
385                 390                 395                 400 


Gly Trp Trp Phe Ser Asp Met Cys Gly Glu Asn Asn Leu Asn Gly Lys 
                405                 410                 415     


Tyr Asn Lys Pro Arg Ala Lys Ser Lys Pro Glu Arg Arg Arg Gly Ile 
            420                 425                 430         


Ser Trp Arg Pro Arg Gly Gly Lys Leu Tyr Ser Ile Lys Ser Ser Lys 
        435                 440                 445             


Met Met Leu Gln Pro Thr Thr 
    450                 455 


<210> 176
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 176
Ser Arg Val Asp Pro Asp Leu Ser Pro Phe Asp Ser Val Pro Ser Glu 
1               5                   10                  15      


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
            20                  25                  30          


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
        35                  40                  45              


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
    50                  55                  60                  


Cys Phe Tyr Asp Leu Ser Leu Gln Thr Asn Glu Ile Lys Glu Glu Glu 
65                  70                  75                  80  


Lys Glu Leu Arg Arg Thr Thr Ser Lys Leu Gln Val Lys Asn Glu Glu 
                85                  90                  95      


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
            100                 105                 110         


Glu Glu Lys Met Ala Leu Gln His Arg Val Arg Ala Leu Glu Glu Gln 
        115                 120                 125             


Leu Thr Ser Leu Val Gln Asn Pro Pro Gly Ala Arg Glu His Pro Glu 
    130                 135                 140                 


Val Thr Ser Leu Lys Ser Phe Val Glu Gln Gln Asp Asn Ser Ile Arg 
145                 150                 155                 160 


Glu Leu Leu Gln Ser Val Glu Glu Gln Tyr Lys Gln Leu Ser Gln Gln 
                165                 170                 175     


His Ile Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Lys Thr Gly Ile 
            180                 185                 190         


Gln Glu Pro Thr Glu Asn Ser Leu Tyr Ser Lys Pro Arg Ala Pro Arg 
        195                 200                 205             


Thr Thr Pro Pro Leu His Leu Lys Glu Ala Lys Asn Ile Glu Gln Asp 
    210                 215                 220                 


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys Leu 
225                 230                 235                 240 


Ile Ser Glu Glu Asp Leu His His His His His His 
                245                 250         


<210> 177
<211> 210
<212> PRT
<213> Macaca fascicularis

<400> 177
Met Phe Thr Ile Lys Leu Leu Leu Phe Ile Val Pro Leu Val Ile Ser 
1               5                   10                  15      


Ser Arg Ile Asp Gln Asp Asn Ser Ser Phe Asp Ser Val Ser Pro Glu 
            20                  25                  30          


Pro Lys Ser Arg Phe Ala Met Leu Asp Asp Val Lys Ile Leu Ala Asn 
        35                  40                  45              


Gly Leu Leu Gln Leu Gly His Gly Leu Lys Asp Phe Val His Lys Thr 
    50                  55                  60                  


Lys Gly Gln Ile Asn Asp Ile Phe Gln Lys Leu Asn Ile Phe Asp Gln 
65                  70                  75                  80  


Ser Phe Tyr Asp Leu Ser Leu Gln Thr Ser Glu Ile Lys Glu Glu Glu 
                85                  90                  95      


Lys Glu Leu Arg Arg Thr Thr Tyr Lys Leu Gln Val Lys Asn Glu Glu 
            100                 105                 110         


Val Lys Asn Met Ser Leu Glu Leu Asn Ser Lys Leu Glu Ser Leu Leu 
        115                 120                 125             


Glu Glu Lys Ile Leu Leu Gln Gln Lys Val Lys Tyr Leu Glu Glu Gln 
    130                 135                 140                 


Leu Thr Asn Leu Ile Gln Asn Gln Pro Ala Thr Pro Glu His Pro Glu 
145                 150                 155                 160 


Val Thr Ser Leu Lys Ser Phe Val Glu Lys Gln Asp Asn Ser Ile Lys 
                165                 170                 175     


Asp Leu Leu Gln Thr Val Glu Glu Gln Tyr Lys Gln Leu Asn Gln Gln 
            180                 185                 190         


His Ser Gln Ile Lys Glu Ile Glu Asn Gln Leu Arg Met Thr Asn Ile 
        195                 200                 205             


Gln Glu 
    210 


<210> 178
<211> 356
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 178
Gly Pro Val Gln Ser Lys Ser Pro Arg Phe Ala Ser Trp Asp Glu Met 
1               5                   10                  15      


Asn Val Leu Ala His Gly Leu Leu Gln Leu Gly Gln Gly Leu Arg Glu 
            20                  25                  30          


His Ala Glu Arg Thr Arg Ser Gln Leu Ser Ala Leu Glu Arg Arg Leu 
        35                  40                  45              


Ser Ala Cys Gly Ser Ala Cys Gln Gly Thr Glu Gly Ser Thr Asp Leu 
    50                  55                  60                  


Pro Leu Ala Pro Glu Ser Arg Val Asp Pro Glu Val Leu His Ser Leu 
65                  70                  75                  80  


Gln Thr Gln Leu Lys Ala Gln Asn Ser Arg Ile Gln Gln Leu Phe His 
                85                  90                  95      


Lys Val Ala Gln Gln Gln Arg His Leu Glu Lys Gln His Leu Arg Ile 
            100                 105                 110         


Gln His Leu Gln Ser Gln Phe Gly Leu Leu Asp Glu Pro Arg Gly Pro 
        115                 120                 125             


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
145                 150                 155                 160 


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
            180                 185                 190         


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
        195                 200                 205             


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
    210                 215                 220                 


Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
                245                 250                 255     


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
            260                 265                 270         


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
        275                 280                 285             


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
305                 310                 315                 320 


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
                325                 330                 335     


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
            340                 345                 350         


Thr Pro Gly Lys 
        355     


<210> 179
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 179
gaggtgcagc ttttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc acctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggaggg ggtctcaggt attagtggta ctggttatag aacatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa ctcgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatcgg      300

ggcttactat ggttcgggga attaacctac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210> 180
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 180
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Thr Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Gly Leu Leu Trp Phe Gly Glu Leu Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 181
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 181
ggattcacct ttagcaccta tgcc                                              24


<210> 182
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 182
Gly Phe Thr Phe Ser Thr Tyr Ala 
1               5               


<210> 183
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 183
attagtggta ctggttatag aaca                                              24


<210> 184
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 184
Ile Ser Gly Thr Gly Tyr Arg Thr 
1               5               


<210> 185
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 185
gcgaaagatc ggggcttact atggttcggg gaattaacct ac                          42


<210> 186
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 186
Ala Lys Asp Arg Gly Leu Leu Trp Phe Gly Glu Leu Thr Tyr 
1               5                   10                  


<210> 187
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 187
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattaat aactggttgg cctggtatca acagaaacca      120

gggaaggccc ctaacctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacaa tataatgatt attggacgtt cggccaaggg      300

accaaggtgg aaatcaaa                                                    318


<210> 188
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 188
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asp Tyr Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210> 189
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 189
cagagtatta ataactgg                                                     18


<210> 190
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 190
Gln Ser Ile Asn Asn Trp 
1               5       


<210> 191
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 191
aaggcgtct                                                                9


<210> 192
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 192
Lys Ala Ser 
1           


<210> 193
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 193
caacaatata atgattattg gacg                                              24


<210> 194
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 194
Gln Gln Tyr Asn Asp Tyr Trp Thr 
1               5               


<210> 195
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 195
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Phe Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Asn Thr Ile Phe Gly Val Val Ile Pro Asp Ala 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Leu Gly Lys 
    450             


<210> 196
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 196
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


