                         SEQUENCE LISTING

<110>  Immatics US, Inc.
 
<120>  VIRAL VECTORS AND USE THEREOF IN ADOPTIVE CELLULLAR THERAPY

<130>  3000011-013977

<150>  US 62/853,123
<151>  2019-05-27

<160>  266   

<170>  PatentIn version 3.5

<210>  1
<211>  367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine stem cell virus promoter

<400>  1
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcact                                                                367


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin

<400>  2

Arg Ala Lys Arg 
1               


<210>  3
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide

<400>  3

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A peptide

<400>  4

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A peptide

<400>  5

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  6
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A peptide

<400>  6

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin consensus sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Arg Xaa Xaa Arg 
1               


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide

<400>  8

Ser Gly Ser Gly 
1               


<210>  9
<211>  607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE

<400>  9
cagtctgacg tacgcgtaat caacctctgg attacaaaat ttgtgaaaga ttgactggta       60

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc      120

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt      180

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg      240

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt      300

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct      360

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aagctgacgt      420

cctttccatg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct      480

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc      540

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct      600

ccccgcc                                                                607


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  X protein promoter

<400>  10
ggggaagctg acgtcctttc c                                                 21


<210>  11
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  12
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Pro 
        195                 200                 205             


Gln Gly Glu Gly Ile Ser Gly Thr Phe Val Pro Gln Cys Leu His Gly 
    210                 215                 220                 


Tyr Tyr Ser Asn Thr Thr Thr Ser Gln Lys Leu Leu Asn Pro Trp Ile 
225                 230                 235                 240 


Leu Lys Thr 
            


<210>  13
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11KEA alpha chain

<400>  13

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  14
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11KE beta chain

<400>  14

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Glu Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  15
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Glu Lys Met Leu Glu Cys Ala Phe Ile Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Gly Trp Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu 
            20                  25                  30          


Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val 
        35                  40                  45              


Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly 
    50                  55                  60                  


Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys 
65                  70                  75                  80  


Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile 
                85                  90                  95      


Thr Ala Pro Lys Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Gln 
            100                 105                 110         


Gly Glu Asn Ser Gly Tyr Ser Thr Leu Thr Phe Gly Lys Gly Thr Met 
        115                 120                 125             


Leu Leu Val Ser Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  16
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Pro Gly Leu Ala Ala Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  17
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Tyr Ser Ser Ala Ser Lys Ile Ile Phe Gly Ser Gly Thr Arg Leu Ser 
        115                 120                 125             


Ile Arg Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  18
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Arg Ala Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  19
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Gly Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys 
        115                 120                 125             


Gly Thr Arg Leu Ser Val Ile Ala Asn Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  20
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ser Ser Gly Ser His Gln Glu Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310             


<210>  21
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ser Lys Glu Thr Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val Val 
        115                 120                 125             


Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  22
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Trp Ser Gln His Pro 
            20                  25                  30          


Ser Val Trp Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg 
        35                  40                  45              


Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro 
    50                  55                  60                  


Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala 
65                  70                  75                  80  


Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala 
                85                  90                  95      


Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp 
            100                 105                 110         


Ser Ser Phe Tyr Ile Cys Ser Ala Arg Ala Gly Gly His Glu Gln Phe 
        115                 120                 125             


Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val 
    130                 135                 140                 


Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser 
145                 150                 155                 160 


His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro 
                165                 170                 175     


Asp His Val Glu Leu Ser Trp Val Trp Asn Gly Lys Glu Val His Ser 
            180                 185                 190         


Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn 
        195                 200                 205             


Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
    210                 215                 220                 


Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly 
225                 230                 235                 240 


Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr 
                245                 250                 255     


Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr 
            260                 265                 270         


Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
        275                 280                 285             


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu 
    290                 295                 300                 


Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 315         


<210>  23
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Phe His Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg Leu His Ile 
        115                 120                 125             


Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  24
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile His Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Ala Ser Ala Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Phe 
305             


<210>  25
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala 
            100                 105                 110         


Tyr Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys 
        115                 120                 125             


Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  26
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Glu Ser Ser Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Phe 
305             


<210>  27
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Lys Ala Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val 
        115                 120                 125             


Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  28
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Thr Arg Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Ala 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Phe Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Phe Ala Glu Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Leu Thr Ser Gly Gly Asp Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  29
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Val 
            100                 105                 110         


Ser Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys 
        115                 120                 125             


Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  30
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ser Thr Ser Gly Gly Leu Ser Gly Glu Thr Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  31
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ala Tyr Gly Lys Leu Gln Phe Gly Ala Gly Thr Gln Val Val 
        115                 120                 125             


Val Thr Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  32
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Ser Pro Asp Gly Asn Gln Pro Gln His Phe Gly Asp 
        115                 120                 125             


Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210>  33
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Tyr Asn Ser Tyr Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe 
        115                 120                 125             


Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile Gln Asn Pro Asp 
    130                 135                 140                 


Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val 
145                 150                 155                 160 


Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys 
                165                 170                 175     


Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser 
            180                 185                 190         


Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp 
        195                 200                 205             


Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr 
    210                 215                 220                 


Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys 
225                 230                 235                 240 


Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile 
                245                 250                 255     


Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
            260                 265                 270         


Thr Leu Arg Leu Trp Ser Ser 
        275                 


<210>  34
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Lys Ser Val Ser Trp Tyr Gln Gln Val Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Lys Glu Glu Arg Gly Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Ala Arg Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Asp Gly Thr Ser Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  35
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Leu Ile Gly 
            100                 105                 110         


Ala Ser Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val 
        115                 120                 125             


Asn Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  36
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Tyr Phe Gly Trp Asn Glu Lys Leu Phe Phe Gly Ser Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Phe 
305                 310 


<210>  37
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Ser Asp Val Ser Gly Gly Tyr Asn Lys Leu Ile Phe Gly Ala Gly 
        115                 120                 125             


Thr Arg Leu Ala Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  38
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Thr Thr Pro Asp Gly Thr Asp Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  39
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Met Asn Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg 
        115                 120                 125             


Leu His Ile Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  40
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Ala Glu Gly Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  41
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Pro Thr Gly Gly Tyr Asn Lys Leu Ile Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Ala Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  42
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Gly Ala Ser Gln Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  43
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Lys Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Leu Phe Asn Phe Asn Lys 
            100                 105                 110         


Phe Tyr Phe Gly Ser Gly Thr Lys Leu Asn Val Lys Pro Asn Ile Gln 
        115                 120                 125             


Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp 
    130                 135                 140                 


Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser 
145                 150                 155                 160 


Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp 
                165                 170                 175     


Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn 
            180                 185                 190         


Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro 
        195                 200                 205             


Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu 
    210                 215                 220                 


Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu 
225                 230                 235                 240 


Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
                245                 250                 255     


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265     


<210>  44
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gly Pro Gly Leu Leu His Trp Met Ala Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly His Gly Asp Ala Met Val Ile Gln Asn Pro Arg Tyr Gln Val Thr 
            20                  25                  30          


Gln Phe Gly Lys Pro Val Thr Leu Ser Cys Ser Gln Thr Leu Asn His 
        35                  40                  45              


Asn Val Met Tyr Trp Tyr Gln Gln Lys Ser Ser Gln Ala Pro Lys Leu 
    50                  55                  60                  


Leu Phe His Tyr Tyr Asp Lys Asp Phe Asn Asn Glu Ala Asp Thr Pro 
65                  70                  75                  80  


Asp Asn Phe Gln Ser Arg Arg Pro Asn Thr Ser Phe Cys Phe Leu Asp 
                85                  90                  95      


Ile Arg Ser Pro Gly Leu Gly Asp Ala Ala Met Tyr Leu Cys Ala Thr 
            100                 105                 110         


Ser Ser Gly Glu Thr Asn Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln 
        115                 120                 125             


Leu Ser Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Phe 
305                 


<210>  45
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Thr Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu 
1               5                   10                  15      


Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Phe Gly Tyr Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr His Leu Ile Ile Gln Pro Tyr Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  46
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Asn Glu Gly Gln Gly Trp Glu Ala Glu Ala Phe Phe Gly Gln Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Phe 
305                 310     


<210>  47
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Lys Arg Ile Leu Gly Ala Leu Leu Gly Leu Leu Ser Ala Gln Val 
1               5                   10                  15      


Cys Cys Val Arg Gly Ile Gln Val Glu Gln Ser Pro Pro Asp Leu Ile 
            20                  25                  30          


Leu Gln Glu Gly Ala Asn Ser Thr Leu Arg Cys Asn Phe Ser Asp Ser 
        35                  40                  45              


Val Asn Asn Leu Gln Trp Phe His Gln Asn Pro Trp Gly Gln Leu Ile 
    50                  55                  60                  


Asn Leu Phe Tyr Ile Pro Ser Gly Thr Lys Gln Asn Gly Arg Leu Ser 
65                  70                  75                  80  


Ala Thr Thr Val Ala Thr Glu Arg Tyr Ser Leu Leu Tyr Ile Ser Ser 
                85                  90                  95      


Ser Gln Thr Thr Asp Ser Gly Val Tyr Phe Cys Ala Val His Asn Phe 
            100                 105                 110         


Asn Lys Phe Tyr Phe Gly Ser Gly Thr Lys Leu Asn Val Lys Pro Asn 
        115                 120                 125             


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
    130                 135                 140                 


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
145                 150                 155                 160 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
                165                 170                 175     


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
            180                 185                 190         


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
        195                 200                 205             


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
    210                 215                 220                 


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  48
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Leu Gly Gln Gly 
        115                 120                 125             


Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
    130                 135                 140                 


Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
145                 150                 155                 160 


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
                165                 170                 175     


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
            180                 185                 190         


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
        195                 200                 205             


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
    210                 215                 220                 


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
225                 230                 235                 240 


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
                245                 250                 255     


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
            260                 265                 270         


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
        275                 280                 285             


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
    290                 295                 300                 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
305                 310                 315                 320 


Arg Gly 
        


<210>  49
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Asn Asn Asn Ala Gly Asn Met Leu Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  50
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Pro Thr Gly Thr Ser 
        115                 120                 125             


Gly Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
    130                 135                 140                 


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
145                 150                 155                 160 


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
                165                 170                 175     


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
            180                 185                 190         


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
        195                 200                 205             


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
    210                 215                 220                 


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
225                 230                 235                 240 


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
                245                 250                 255     


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
            260                 265                 270         


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
        275                 280                 285             


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
    290                 295                 300                 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
305                 310                 315                 320 


Ser Arg Gly 
            


<210>  51
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Asn Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg Leu 
        115                 120                 125             


His Ile Leu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  52
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Arg Leu Pro Ser Arg Thr Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  53
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn 
            100                 105                 110         


Ser Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg 
        115                 120                 125             


Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  54
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Gly Leu Gly Thr 
        115                 120                 125             


Gly Asp Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val Val 
    130                 135                 140                 


Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
145                 150                 155                 160 


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
                165                 170                 175     


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
            180                 185                 190         


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
        195                 200                 205             


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
    210                 215                 220                 


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
225                 230                 235                 240 


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
                245                 250                 255     


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
            260                 265                 270         


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
        275                 280                 285             


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
    290                 295                 300                 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
305                 310                 315                 320 


Phe 
    


<210>  55
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  56
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Leu Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  57
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala 
            100                 105                 110         


Val Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210>  58
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Pro Trp Asp Ser Pro Asn Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  59
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Ser Glu Ala Ala Gly Asn Lys Leu Thr Phe Gly Gly Gly Thr Arg 
        115                 120                 125             


Val Leu Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  60
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Tyr Thr Asn Gln Gly Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Phe 
305                 


<210>  61
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Leu Asn Gln Ala Gly Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu 
        115                 120                 125             


Ser Val Ser Ser Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  62
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gly Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ala Glu Thr Gly Pro Trp Leu Gly Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 


<210>  63
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Tyr Arg Trp Ala Gln Gly Gly Ser Glu Lys Leu Val Phe Gly Lys 
        115                 120                 125             


Gly Thr Lys Leu Thr Val Asn Pro Tyr Ile Gln Lys Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  64
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Thr Ile Arg Leu Leu Cys Tyr Met Gly Phe Tyr Phe Leu Gly Ala 
1               5                   10                  15      


Gly Leu Met Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile 
            20                  25                  30          


Gly Thr Gly Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His 
        35                  40                  45              


Asp Lys Met Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser 
65                  70                  75                  80  


Ser Glu Ser Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Thr 
            100                 105                 110         


Glu Leu Trp Ser Ser Gly Gly Thr Gly Glu Leu Phe Phe Gly Glu Gly 
        115                 120                 125             


Ser Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310             


<210>  65
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  65

Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr 
1               5                   10                  15      


Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp 
            20                  25                  30          


Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Gly Pro Ser 
        35                  40                  45              


Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu Lys Val Leu 
    50                  55                  60                  


Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
65                  70                  75                  80  


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                85                  90                  95      


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
            100                 105                 110         


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
        115                 120                 125             


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
    130                 135                 140                 


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
145                 150                 155                 160 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
                165                 170                 175     


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
            180                 185                 190         


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        195                 200                 205     


<210>  66
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Gly Gly Ser Gly Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  67
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Val Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr His 
        115                 120                 125             


Leu Ile Ile Gln Pro Tyr Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  68
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Gly Arg Gly Gly 
        115                 120                 125             


Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp 
    130                 135                 140                 


Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu 
145                 150                 155                 160 


Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr 
                165                 170                 175     


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
            180                 185                 190         


Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln 
        195                 200                 205             


Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val 
    210                 215                 220                 


Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val 
225                 230                 235                 240 


Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala 
                245                 250                 255     


Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp 
            260                 265                 270         


Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
        275                 280                 285             


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
    290                 295                 300                 


Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
305                 310                 315                 


<210>  69
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11P3D3KE alpha chain

<400>  69

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Lys Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  70
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R11P3D3KE beta chain

<400>  70

Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe 
1               5                   10                  15      


Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro 
            20                  25                  30          


Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Gly 
        35                  40                  45              


Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
    50                  55                  60                  


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
65                  70                  75                  80  


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
                85                  90                  95      


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
            100                 105                 110         


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
        115                 120                 125             


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
    130                 135                 140                 


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
145                 150                 155                 160 


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
                165                 170                 175     


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
            180                 185                 190         


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
        195                 200                 205             


Ala Thr Leu Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
    210                 215                 220                 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
225                 230                 235                 240 


Ser Arg Gly 
            


<210>  71
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  71

Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu Gln Leu 
1               5                   10                  15      


Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln Arg Leu 
            20                  25                  30          


Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg Ile Ala 
        35                  40                  45              


Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu Ile Asp 
    50                  55                  60                  


Asn Gln Gly Gly Lys Leu Ile Phe Gly Gln Gly Thr Glu Leu Ser Val 
65                  70                  75                  80  


Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
                85                  90                  95      


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
            100                 105                 110         


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
        115                 120                 125             


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
    130                 135                 140                 


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
145                 150                 155                 160 


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
                165                 170                 175     


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
            180                 185                 190         


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
        195                 200                 205             


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    210                 215                 220             


<210>  72
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Gly Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Leu Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
            180                 185                 190         


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
225                 230                 235                 240 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asp Phe 
305         


<210>  73
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Asn Ala Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val Val Lys 
        115                 120                 125             


Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  74
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gly Gln Gly Ala Asn Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  75
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Tyr Leu Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile 
        115                 120                 125             


Ile Lys Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  76
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Glu Met Thr Ala Val Gly Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  77
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala 
            100                 105                 110         


Phe Ser Gly Tyr Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val 
        115                 120                 125             


Thr Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
    130                 135                 140                 


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
            180                 185                 190         


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
        195                 200                 205             


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
    210                 215                 220                 


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  78
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gln Tyr Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  79
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Gly Gly Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys 
        115                 120                 125             


Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
    130                 135                 140                 


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
            180                 185                 190         


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
        195                 200                 205             


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
    210                 215                 220                 


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  80
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gly Gln Gly Ala Leu Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  81
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro 
1               5                   10                  15      


Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln 
            20                  25                  30          


Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn 
        35                  40                  45              


Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys 
    50                  55                  60                  


Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys 
65                  70                  75                  80  


Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala 
                85                  90                  95      


Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Ser Gly Leu Tyr Asn Gln Gly Gly Lys Leu 
        115                 120                 125             


Ile Phe Gly Gln Gly Thr Glu Leu Ser Val Lys Pro Asn Ile Gln Asn 
    130                 135                 140                 


Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
145                 150                 155                 160 


Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln 
                165                 170                 175     


Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met 
            180                 185                 190         


Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys 
        195                 200                 205             


Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu 
    210                 215                 220                 


Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val 
225                 230                 235                 240 


Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser 
                245                 250                 255     


Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
            260                 265                 270         


Leu Met Thr Leu Arg Leu Trp Ser Ser 
        275                 280     


<210>  82
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Gly Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Asp Arg Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  83
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ile Asn Asn Asn Ala Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  84
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Val Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Pro Pro Asp Gln Asn 
        115                 120                 125             


Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu 
    130                 135                 140                 


Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala 
145                 150                 155                 160 


Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly 
                165                 170                 175     


Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro 
        195                 200                 205             


Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
    210                 215                 220                 


Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
225                 230                 235                 240 


Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys 
                245                 250                 255     


Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
            260                 265                 270         


Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
        275                 280                 285             


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
    290                 295                 300                 


Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
305                 310                 315                 320 


<210>  85
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Leu Leu Leu Leu Val Pro Val Leu Glu Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Gly Ser His Val Ser Val 
            20                  25                  30          


Ser Glu Gly Ala Leu Val Leu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Pro Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Thr Thr Gly Ala Thr Leu Val Lys Gly Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Lys Lys Ser Glu Thr Ser Phe His Leu Thr 
                85                  90                  95      


Lys Pro Ser Ala His Met Ser Asp Ala Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Ile Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu 
        115                 120                 125             


Thr Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  86
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Met Gly Glu Leu Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Ser Arg Gly 
305                 310         


<210>  87
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Met Gly Asp Thr Gly Thr Ala Ser Lys Leu Thr Phe Gly Thr Gly 
        115                 120                 125             


Thr Arg Leu Gln Val Thr Leu Asp Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  88
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Phe Gly Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
            180                 185                 190         


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
225                 230                 235                 240 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asp Ser Arg Gly 
305                 


<210>  89
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  89

Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
1               5                   10                  15      


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
            20                  25                  30          


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
        35                  40                  45              


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
    50                  55                  60                  


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
65                  70                  75                  80  


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
                85                  90                  95      


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
            100                 105                 110         


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
        115                 120                 125             


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140                 


<210>  90
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Leu Cys Ser Leu Leu Ala Leu Leu Leu Gly Thr Phe Phe Gly Val 
1               5                   10                  15      


Arg Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val 
            20                  25                  30          


Gly Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro 
        35                  40                  45              


Asn Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu 
    50                  55                  60                  


Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn 
65                  70                  75                  80  


Leu Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys 
                85                  90                  95      


Lys Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Gly 
            100                 105                 110         


Leu Val Ala Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
        115                 120                 125             


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
    130                 135                 140                 


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
                165                 170                 175     


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
            180                 185                 190         


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
225                 230                 235                 240 


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
    290                 295                 300                 


Ser Arg Gly 
305         


<210>  91
<211>  4445
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTE WPRE

<400>  91
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gactcttgga ccttctgctg      420

cgtgagcctg tgcatcctgg tggccaagca cacagacgcc ggcgtgatcc agtcccctag      480

gcacgaggtg accgagatgg gccaggaggt gacactgcgc tgtaagccaa tctctggcca      540

caacagcctg ttttggtata gggagaccat gatgcgcggc ctggagctgc tgatctactt      600

caataacaat gtgcccatcg acgattccgg catgcctgag gatcggtttt ctgccaagat      660

gcccaatgcc agcttctcca cactgaagat ccagcctagc gagccaagag actccgccgt      720

gtatttttgc gcctctagcc caggcagcac cgatacacag tacttcggac caggaaccag      780

gctgacagtg ctggaggacc tgaagaacgt gttcccccct gaggtggccg tgtttgagcc      840

ctctgaggcc gagatcagcc acacccagaa ggccaccctg gtgtgcctgg caaccggctt      900

ctatcctgat cacgtggagc tgtcctggtg ggtgaacggc aaggaggtgc acagcggcgt      960

gtccacagac ccacagcccc tgaaggagca gccagccctg aatgatagcc ggtattgcct     1020

gtcctctcgg ctgagagtgt ccgccacctt ttggcagaac ccccggaatc acttcagatg     1080

tcaggtgcag ttttacggcc tgtccgagaa cgatgagtgg acccaggacc gggccaagcc     1140

tgtgacacag atcgtgtctg ccgaggcatg gggaagagca gactgtggct tcacctctga     1200

gagctaccag cagggcgtgc tgagcgccac catcctgtat gagatcctgc tgggcaaggc     1260

cacactgtac gccgtcctgg tctccgctct ggtgctgatg gcaatggtca aaagaaaaga     1320

tagtcgggga cgggccaaga gatctggcag cggcgccacc aatttcagcc tgctgaaaca     1380

ggccggcgac gtggaagaga accctggccc catggagaag aatcccctgg ctgcccccct     1440

gctgatcctg tggtttcacc tggactgcgt gtcctctatc ctgaatgtgg aacagagccc     1500

acagagcctg cacgtgcagg agggcgactc caccaacttc acatgctctt ttcctagctc     1560

caacttctac gccctgcact ggtacagaaa ggagaccgca aagtccccag aggccctgtt     1620

cgtgatgaca ctgaacggcg atgagaagaa gaagggccgc atcagcgcca ccctgaatac     1680

aaaggagggc tactcctatc tgtacatcaa gggctcccag cctgaggact ctgccaccta     1740

tctgtgcgcc ctgtacaaca ataacgatat gcggtttggc gccggcacca gactgacagt     1800

gaagccaaac atccagaatc cagaccccgc cgtgtatcag ctgcgggaca gcaagtctag     1860

cgataagagc gtgtgcctgt tcaccgactt tgattctcag acaaacgtga gccagtccaa     1920

ggacagcgac gtgtacatca ccgacaagac agtgctggat atgagaagca tggacttcaa     1980

gtctaacagc gccgtggcct ggtccaataa gtctgatttc gcctgcgcca atgcctttaa     2040

taactccatc atccccgagg ataccttctt tccttctcca gagtcctctt gtgacgtgaa     2100

gctggtggag aagtctttcg agaccgatac aaacctgaat tttcagaacc tgagcgtgat     2160

cggcttcagg atcctgctgc tgaaggtggc cggctttaat ctgctgatga ccctgaggct     2220

gtggagctcc cgggccaaga gatctggcag cggcgagggc agaggcagcc tgctgacctg     2280

cggcgacgtg gaggagaacc ccggccccat gcgcccgaga ctgtggcttc tgctcgccgc     2340

gcaactgact gtcctgcacg gaaacagcgt gctgcagcag acaccggcct acatcaaagt     2400

gcagaccaac aagatggtca tgctgtcctg cgaggccaag atttccctct ccaacatgcg     2460

gatctattgg ttgcggcaga gacaggcgcc ttcctcggac tcccaccatg agttcttggc     2520

cctgtgggac tccgccaagg gaactattca cggcgaagaa gtggaacagg agaagatcgc     2580

cgtgtttcgc gatgcctccc gctttatact gaatctgacc tccgtgaagc ccgaagatag     2640

cgggatctac ttttgcatga ttgtgggctc acccgaactg accttcggga agggcactca     2700

gctgagcgtg gtggacttcc tccccactac cgcccaaccc actaagaagt caaccctgaa     2760

gaagcgggtt tgcagactcc cacggccgga aacgcagaag ggtccgctgt gttccccgat     2820

caccctgggg ctccttgtgg ctggagtgct ggtccttctg gtgtcccttg gcgtcgccat     2880

tcacctctgc tgccggagaa ggagggccag actgaggttc atgaagcagc ctcagggaga     2940

ggggatcagt ggcactttcg tgccacaatg cctccatggc tactattcca acaccaccac     3000

ctcgcaaaag ctgctgaacc cctggatcct gaaaacccgg gccaagagat ctggcagcgg     3060

ccagtgcacc aactacgccc tgctgaagct ggccggcgac gtggagagca accccggccc     3120

catggcgctt cccgtgaccg cactcctgtt gccccttgcc ctgctgttgc acgccgcacg     3180

accttcccaa ttccgggtgt cccctctgga tcgcacctgg aacctcgggg aaacggtgga     3240

gctcaagtgt caagtcctcc tgtcgaaccc gaccagcgga tgcagctggc tgttccagcc     3300

gagaggagct gccgcctcac ccaccttcct cctgtacttg agccagaaca agccgaaggc     3360

cgctgagggt ctggacaccc agcgcttctc gggcaaacgg ctgggagaca cttttgtgct     3420

gactctctcc gacttccggc gggagaacga gggctactac ttctgctctg cgctctccaa     3480

ttcaatcatg tacttctcac acttcgtgcc ggtgttcctg cctgccaagc ccaccactac     3540

tccggcaccc agacctccaa ctcccgctcc caccatcgcg tcccaacccc tttcgctgcg     3600

ccctgaagcg tgtcggcctg ctgctggagg agccgtgcat acccgcggtc tggacttcgc     3660

gtgcgacatc tacatttggg cccctttggc tggcacctgt ggagtgctgc tcctgtccct     3720

tgtgatcacc ctgtactgca accaccggaa taggcggaga gtctgcaagt gtccgcggcc     3780

tgtcgtgaag tcaggagata agccgagcct gtccgcacgc tacgtgtgaa ccggtccgca     3840

gtctgacgta cgcgtaatca acctctggat tacaaaattt gtgaaagatt gactggtatt     3900

cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat     3960

gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct     4020

ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct     4080

gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc     4140

gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg     4200

acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa gctgacgtcc     4260

tttccatggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac     4320

gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg     4380

cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc     4440

ccgcc                                                                 4445


<210>  92
<211>  4445
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPE WPRE

<400>  92
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gactcttgga ccttctgctg      420

cgtgagcctg tgcatcctgg tggccaagca cacagacgcc ggcgtgatcc agtcccctag      480

gcacgaggtg accgagatgg gccaggaggt gacactgcgc tgtaagccaa tctctggcca      540

caacagcctg ttttggtata gggagaccat gatgcgcggc ctggagctgc tgatctactt      600

caataacaat gtgcccatcg acgattccgg catgcctgag gatcggtttt ctgccaagat      660

gcccaatgcc agcttctcca cactgaagat ccagcctagc gagccaagag actccgccgt      720

gtatttttgc gcctctagcc caggcagcac cgatacacag tacttcggac caggaaccag      780

gctgacagtg ctggaggacc tgaagaacgt gttcccccct gaggtggccg tgtttgagcc      840

ctctgaggcc gagatcagcc acacccagaa ggccaccctg gtgtgcctgg caaccggctt      900

ctatcctgat cacgtggagc tgtcctggtg ggtgaacggc aaggaggtgc acagcggcgt      960

gtccacagac ccacagcccc tgaaggagca gccagccctg aatgatagcc ggtattgcct     1020

gtcctctcgg ctgagagtgt ccgccacctt ttggcagaac ccccggaatc acttcagatg     1080

tcaggtgcag ttttacggcc tgtccgagaa cgatgagtgg acccaggacc gggccaagcc     1140

tgtgacacag atcgtgtctg ccgaggcatg gggaagagca gactgtggct tcacctctga     1200

gagctaccag cagggcgtgc tgagcgccac catcctgtat gagatcctgc tgggcaaggc     1260

cacactgtac gccgtcctgg tctccgctct ggtgctgatg gcaatggtca aaagaaaaga     1320

tagtcgggga cgggccaaga gatctggcag cggcgagggc agaggcagcc tgctgacctg     1380

cggcgacgtg gaggagaacc ccggccccat ggagaagaat cccctggctg cccccctgct     1440

gatcctgtgg tttcacctgg actgcgtgtc ctctatcctg aatgtggaac agagcccaca     1500

gagcctgcac gtgcaggagg gcgactccac caacttcaca tgctcttttc ctagctccaa     1560

cttctacgcc ctgcactggt acagaaagga gaccgcaaag tccccagagg ccctgttcgt     1620

gatgacactg aacggcgatg agaagaagaa gggccgcatc agcgccaccc tgaatacaaa     1680

ggagggctac tcctatctgt acatcaaggg ctcccagcct gaggactctg ccacctatct     1740

gtgcgccctg tacaacaata acgatatgcg gtttggcgcc ggcaccagac tgacagtgaa     1800

gccaaacatc cagaatccag accccgccgt gtatcagctg cgggacagca agtctagcga     1860

taagagcgtg tgcctgttca ccgactttga ttctcagaca aacgtgagcc agtccaagga     1920

cagcgacgtg tacatcaccg acaagacagt gctggatatg agaagcatgg acttcaagtc     1980

taacagcgcc gtggcctggt ccaataagtc tgatttcgcc tgcgccaatg cctttaataa     2040

ctccatcatc cccgaggata ccttctttcc ttctccagag tcctcttgtg acgtgaagct     2100

ggtggagaag tctttcgaga ccgatacaaa cctgaatttt cagaacctga gcgtgatcgg     2160

cttcaggatc ctgctgctga aggtggccgg ctttaatctg ctgatgaccc tgaggctgtg     2220

gagctcccgg gccaagagat ctggcagcgg cgccaccaat ttcagcctgc tgaaacaggc     2280

cggcgacgtg gaagagaacc ctggccccat gcgcccgaga ctgtggcttc tgctcgccgc     2340

gcaactgact gtcctgcacg gaaacagcgt gctgcagcag acaccggcct acatcaaagt     2400

gcagaccaac aagatggtca tgctgtcctg cgaggccaag atttccctct ccaacatgcg     2460

gatctattgg ttgcggcaga gacaggcgcc ttcctcggac tcccaccatg agttcttggc     2520

cctgtgggac tccgccaagg gaactattca cggcgaagaa gtggaacagg agaagatcgc     2580

cgtgtttcgc gatgcctccc gctttatact gaatctgacc tccgtgaagc ccgaagatag     2640

cgggatctac ttttgcatga ttgtgggctc acccgaactg accttcggga agggcactca     2700

gctgagcgtg gtggacttcc tccccactac cgcccaaccc actaagaagt caaccctgaa     2760

gaagcgggtt tgcagactcc cacggccgga aacgcagaag ggtccgctgt gttccccgat     2820

caccctgggg ctccttgtgg ctggagtgct ggtccttctg gtgtcccttg gcgtcgccat     2880

tcacctctgc tgccggagaa ggagggccag actgaggttc atgaagcagc ctcagggaga     2940

ggggatcagt ggcactttcg tgccacaatg cctccatggc tactattcca acaccaccac     3000

ctcgcaaaag ctgctgaacc cctggatcct gaaaacccgg gccaagagat ctggcagcgg     3060

ccagtgcacc aactacgccc tgctgaagct ggccggcgac gtggagagca accccggccc     3120

catggcgctt cccgtgaccg cactcctgtt gccccttgcc ctgctgttgc acgccgcacg     3180

accttcccaa ttccgggtgt cccctctgga tcgcacctgg aacctcgggg aaacggtgga     3240

gctcaagtgt caagtcctcc tgtcgaaccc gaccagcgga tgcagctggc tgttccagcc     3300

gagaggagct gccgcctcac ccaccttcct cctgtacttg agccagaaca agccgaaggc     3360

cgctgagggt ctggacaccc agcgcttctc gggcaaacgg ctgggagaca cttttgtgct     3420

gactctctcc gacttccggc gggagaacga gggctactac ttctgctctg cgctctccaa     3480

ttcaatcatg tacttctcac acttcgtgcc ggtgttcctg cctgccaagc ccaccactac     3540

tccggcaccc agacctccaa ctcccgctcc caccatcgcg tcccaacccc tttcgctgcg     3600

ccctgaagcg tgtcggcctg ctgctggagg agccgtgcat acccgcggtc tggacttcgc     3660

gtgcgacatc tacatttggg cccctttggc tggcacctgt ggagtgctgc tcctgtccct     3720

tgtgatcacc ctgtactgca accaccggaa taggcggaga gtctgcaagt gtccgcggcc     3780

tgtcgtgaag tcaggagata agccgagcct gtccgcacgc tacgtgtgaa ccggtccgca     3840

gtctgacgta cgcgtaatca acctctggat tacaaaattt gtgaaagatt gactggtatt     3900

cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat     3960

gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct     4020

ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct     4080

gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc     4140

gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg     4200

acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa gctgacgtcc     4260

tttccatggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac     4320

gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg     4380

cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc     4440

ccgcc                                                                 4445


<210>  93
<211>  4430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTE fn WPRE

<400>  93
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gactcttgga ccttctgctg      420

cgtgagcctg tgcatcctgg tggccaagca cacagacgcc ggcgtgatcc agtcccctag      480

gcacgaggtg accgagatgg gccaggaggt gacactgcgc tgtaagccaa tctctggcca      540

caacagcctg ttttggtata gggagaccat gatgcgcggc ctggagctgc tgatctactt      600

caataacaat gtgcccatcg acgattccgg catgcctgag gatcggtttt ctgccaagat      660

gcccaatgcc agcttctcca cactgaagat ccagcctagc gagccaagag actccgccgt      720

gtatttttgc gcctctagcc caggcagcac cgatacacag tacttcggac caggaaccag      780

gctgacagtg ctggaggacc tgaagaacgt gttcccccct gaggtggccg tgtttgagcc      840

ctctgaggcc gagatcagcc acacccagaa ggccaccctg gtgtgcctgg caaccggctt      900

ctatcctgat cacgtggagc tgtcctggtg ggtgaacggc aaggaggtgc acagcggcgt      960

gtccacagac ccacagcccc tgaaggagca gccagccctg aatgatagcc ggtattgcct     1020

gtcctctcgg ctgagagtgt ccgccacctt ttggcagaac ccccggaatc acttcagatg     1080

tcaggtgcag ttttacggcc tgtccgagaa cgatgagtgg acccaggacc gggccaagcc     1140

tgtgacacag atcgtgtctg ccgaggcatg gggaagagca gactgtggct tcacctctga     1200

gagctaccag cagggcgtgc tgagcgccac catcctgtat gagatcctgc tgggcaaggc     1260

cacactgtac gccgtcctgg tctccgctct ggtgctgatg gcaatggtca aaagaaaaga     1320

tagtcgggga tctggcagcg gcgccaccaa tttcagcctg ctgaaacagg ccggcgacgt     1380

ggaagagaac cctggcccca tggagaagaa tcccctggct gcccccctgc tgatcctgtg     1440

gtttcacctg gactgcgtgt cctctatcct gaatgtggaa cagagcccac agagcctgca     1500

cgtgcaggag ggcgactcca ccaacttcac atgctctttt cctagctcca acttctacgc     1560

cctgcactgg tacagaaagg agaccgcaaa gtccccagag gccctgttcg tgatgacact     1620

gaacggcgat gagaagaaga agggccgcat cagcgccacc ctgaatacaa aggagggcta     1680

ctcctatctg tacatcaagg gctcccagcc tgaggactct gccacctatc tgtgcgccct     1740

gtacaacaat aacgatatgc ggtttggcgc cggcaccaga ctgacagtga agccaaacat     1800

ccagaatcca gaccccgccg tgtatcagct gcgggacagc aagtctagcg ataagagcgt     1860

gtgcctgttc accgactttg attctcagac aaacgtgagc cagtccaagg acagcgacgt     1920

gtacatcacc gacaagacag tgctggatat gagaagcatg gacttcaagt ctaacagcgc     1980

cgtggcctgg tccaataagt ctgatttcgc ctgcgccaat gcctttaata actccatcat     2040

ccccgaggat accttctttc cttctccaga gtcctcttgt gacgtgaagc tggtggagaa     2100

gtctttcgag accgatacaa acctgaattt tcagaacctg agcgtgatcg gcttcaggat     2160

cctgctgctg aaggtggccg gctttaatct gctgatgacc ctgaggctgt ggagctcccg     2220

ggccaagaga ggcagcggcg agggcagagg cagcctgctg acctgcggcg acgtggagga     2280

gaaccccggc cccatgcgcc cgagactgtg gcttctgctc gccgcgcaac tgactgtcct     2340

gcacggaaac agcgtgctgc agcagacacc ggcctacatc aaagtgcaga ccaacaagat     2400

ggtcatgctg tcctgcgagg ccaagatttc cctctccaac atgcggatct attggttgcg     2460

gcagagacag gcgccttcct cggactccca ccatgagttc ttggccctgt gggactccgc     2520

caagggaact attcacggcg aagaagtgga acaggagaag atcgccgtgt ttcgcgatgc     2580

ctcccgcttt atactgaatc tgacctccgt gaagcccgaa gatagcggga tctacttttg     2640

catgattgtg ggctcacccg aactgacctt cgggaagggc actcagctga gcgtggtgga     2700

cttcctcccc actaccgccc aacccactaa gaagtcaacc ctgaagaagc gggtttgcag     2760

actcccacgg ccggaaacgc agaagggtcc gctgtgttcc ccgatcaccc tggggctcct     2820

tgtggctgga gtgctggtcc ttctggtgtc ccttggcgtc gccattcacc tctgctgccg     2880

gagaaggagg gccagactga ggttcatgaa gcagcctcag ggagagggga tcagtggcac     2940

tttcgtgcca caatgcctcc atggctacta ttccaacacc accacctcgc aaaagctgct     3000

gaacccctgg atcctgaaaa cccgggccaa gagatctggc agcggccagt gcaccaacta     3060

cgccctgctg aagctggccg gcgacgtgga gagcaacccc ggccccatgg cgcttcccgt     3120

gaccgcactc ctgttgcccc ttgccctgct gttgcacgcc gcacgacctt cccaattccg     3180

ggtgtcccct ctggatcgca cctggaacct cggggaaacg gtggagctca agtgtcaagt     3240

cctcctgtcg aacccgacca gcggatgcag ctggctgttc cagccgagag gagctgccgc     3300

ctcacccacc ttcctcctgt acttgagcca gaacaagccg aaggccgctg agggtctgga     3360

cacccagcgc ttctcgggca aacggctggg agacactttt gtgctgactc tctccgactt     3420

ccggcgggag aacgagggct actacttctg ctctgcgctc tccaattcaa tcatgtactt     3480

ctcacacttc gtgccggtgt tcctgcctgc caagcccacc actactccgg cacccagacc     3540

tccaactccc gctcccacca tcgcgtccca acccctttcg ctgcgccctg aagcgtgtcg     3600

gcctgctgct ggaggagccg tgcatacccg cggtctggac ttcgcgtgcg acatctacat     3660

ttgggcccct ttggctggca cctgtggagt gctgctcctg tcccttgtga tcaccctgta     3720

ctgcaaccac cggaataggc ggagagtctg caagtgtccg cggcctgtcg tgaagtcagg     3780

agataagccg agcctgtccg cacgctacgt gtgaaccggt ccgcagtctg acgtacgcgt     3840

aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct     3900

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt     3960

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg     4020

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact     4080

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct     4140

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg     4200

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc     4260

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc     4320

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt     4380

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc                4430


<210>  94
<211>  4445
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PTE CD8 TCR WPRE

<400>  94
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg cgcccgagac tgtggcttct      420

gctcgccgcg caactgactg tcctgcacgg aaacagcgtg ctgcagcaga caccggccta      480

catcaaagtg cagaccaaca agatggtcat gctgtcctgc gaggccaaga tttccctctc      540

caacatgcgg atctattggt tgcggcagag acaggcgcct tcctcggact cccaccatga      600

gttcttggcc ctgtgggact ccgccaaggg aactattcac ggcgaagaag tggaacagga      660

gaagatcgcc gtgtttcgcg atgcctcccg ctttatactg aatctgacct ccgtgaagcc      720

cgaagatagc gggatctact tttgcatgat tgtgggctca cccgaactga ccttcgggaa      780

gggcactcag ctgagcgtgg tggacttcct ccccactacc gcccaaccca ctaagaagtc      840

aaccctgaag aagcgggttt gcagactccc acggccggaa acgcagaagg gtccgctgtg      900

ttccccgatc accctggggc tccttgtggc tggagtgctg gtccttctgg tgtcccttgg      960

cgtcgccatt cacctctgct gccggagaag gagggccaga ctgaggttca tgaagcagcc     1020

tcagggagag gggatcagtg gcactttcgt gccacaatgc ctccatggct actattccaa     1080

caccaccacc tcgcaaaagc tgctgaaccc ctggatcctg aaaacccggg ccaagagatc     1140

tggcagcggc gccaccaatt tcagcctgct gaaacaggcc ggcgacgtgg aagagaaccc     1200

tggccccatg gcgcttcccg tgaccgcact cctgttgccc cttgccctgc tgttgcacgc     1260

cgcacgacct tcccaattcc gggtgtcccc tctggatcgc acctggaacc tcggggaaac     1320

ggtggagctc aagtgtcaag tcctcctgtc gaacccgacc agcggatgca gctggctgtt     1380

ccagccgaga ggagctgccg cctcacccac cttcctcctg tacttgagcc agaacaagcc     1440

gaaggccgct gagggtctgg acacccagcg cttctcgggc aaacggctgg gagacacttt     1500

tgtgctgact ctctccgact tccggcggga gaacgagggc tactacttct gctctgcgct     1560

ctccaattca atcatgtact tctcacactt cgtgccggtg ttcctgcctg ccaagcccac     1620

cactactccg gcacccagac ctccaactcc cgctcccacc atcgcgtccc aacccctttc     1680

gctgcgccct gaagcgtgtc ggcctgctgc tggaggagcc gtgcataccc gcggtctgga     1740

cttcgcgtgc gacatctaca tttgggcccc tttggctggc acctgtggag tgctgctcct     1800

gtcccttgtg atcaccctgt actgcaacca ccggaatagg cggagagtct gcaagtgtcc     1860

gcggcctgtc gtgaagtcag gagataagcc gagcctgtcc gcacgctacg tgcgggccaa     1920

gagatctggc agcggcgagg gcagaggcag cctgctgacc tgcggcgacg tggaggagaa     1980

ccccggcccc atggactctt ggaccttctg ctgcgtgagc ctgtgcatcc tggtggccaa     2040

gcacacagac gccggcgtga tccagtcccc taggcacgag gtgaccgaga tgggccagga     2100

ggtgacactg cgctgtaagc caatctctgg ccacaacagc ctgttttggt atagggagac     2160

catgatgcgc ggcctggagc tgctgatcta cttcaataac aatgtgccca tcgacgattc     2220

cggcatgcct gaggatcggt tttctgccaa gatgcccaat gccagcttct ccacactgaa     2280

gatccagcct agcgagccaa gagactccgc cgtgtatttt tgcgcctcta gcccaggcag     2340

caccgataca cagtacttcg gaccaggaac caggctgaca gtgctggagg acctgaagaa     2400

cgtgttcccc cctgaggtgg ccgtgtttga gccctctgag gccgagatca gccacaccca     2460

gaaggccacc ctggtgtgcc tggcaaccgg cttctatcct gatcacgtgg agctgtcctg     2520

gtgggtgaac ggcaaggagg tgcacagcgg cgtgtccaca gacccacagc ccctgaagga     2580

gcagccagcc ctgaatgata gccggtattg cctgtcctct cggctgagag tgtccgccac     2640

cttttggcag aacccccgga atcacttcag atgtcaggtg cagttttacg gcctgtccga     2700

gaacgatgag tggacccagg accgggccaa gcctgtgaca cagatcgtgt ctgccgaggc     2760

atggggaaga gcagactgtg gcttcacctc tgagagctac cagcagggcg tgctgagcgc     2820

caccatcctg tatgagatcc tgctgggcaa ggccacactg tacgccgtcc tggtctccgc     2880

tctggtgctg atggcaatgg tcaaaagaaa agatagtcgg ggacgggcca agagatctgg     2940

cagcggccag tgcaccaact acgccctgct gaagctggcc ggcgacgtgg agagcaaccc     3000

cggccccatg gagaagaatc ccctggctgc ccccctgctg atcctgtggt ttcacctgga     3060

ctgcgtgtcc tctatcctga atgtggaaca gagcccacag agcctgcacg tgcaggaggg     3120

cgactccacc aacttcacat gctcttttcc tagctccaac ttctacgccc tgcactggta     3180

cagaaaggag accgcaaagt ccccagaggc cctgttcgtg atgacactga acggcgatga     3240

gaagaagaag ggccgcatca gcgccaccct gaatacaaag gagggctact cctatctgta     3300

catcaagggc tcccagcctg aggactctgc cacctatctg tgcgccctgt acaacaataa     3360

cgatatgcgg tttggcgccg gcaccagact gacagtgaag ccaaacatcc agaatccaga     3420

ccccgccgtg tatcagctgc gggacagcaa gtctagcgat aagagcgtgt gcctgttcac     3480

cgactttgat tctcagacaa acgtgagcca gtccaaggac agcgacgtgt acatcaccga     3540

caagacagtg ctggatatga gaagcatgga cttcaagtct aacagcgccg tggcctggtc     3600

caataagtct gatttcgcct gcgccaatgc ctttaataac tccatcatcc ccgaggatac     3660

cttctttcct tctccagagt cctcttgtga cgtgaagctg gtggagaagt ctttcgagac     3720

cgatacaaac ctgaattttc agaacctgag cgtgatcggc ttcaggatcc tgctgctgaa     3780

ggtggccggc tttaatctgc tgatgaccct gaggctgtgg agctcctgaa ccggtccgca     3840

gtctgacgta cgcgtaatca acctctggat tacaaaattt gtgaaagatt gactggtatt     3900

cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat     3960

gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct     4020

ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct     4080

gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc     4140

gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg     4200

acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa gctgacgtcc     4260

tttccatggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac     4320

gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg     4380

cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc     4440

ccgcc                                                                 4445


<210>  95
<211>  2849
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R11KE WPRE

<400>  95
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg gactcttgga ccttctgctg      420

cgtgagcctg tgcatcctgg tggccaagca cacagacgcc ggcgtgatcc agtcccctag      480

gcacgaggtg accgagatgg gccaggaggt gacactgcgc tgtaagccaa tctctggcca      540

caacagcctg ttttggtata gggagaccat gatgcgcggc ctggagctgc tgatctactt      600

caataacaat gtgcccatcg acgattccgg catgcctgag gatcggtttt ctgccaagat      660

gcccaatgcc agcttctcca cactgaagat ccagcctagc gagccaagag actccgccgt      720

gtatttttgc gcctctagcc caggcagcac cgatacacag tacttcggac caggaaccag      780

gctgacagtg ctggaggacc tgaagaacgt gttcccccct gaggtggccg tgtttgagcc      840

ctctgaggcc gagatcagcc acacccagaa ggccaccctg gtgtgcctgg caaccggctt      900

ctatcctgat cacgtggagc tgtcctggtg ggtgaacggc aaggaggtgc acagcggcgt      960

gtccacagac ccacagcccc tgaaggagca gccagccctg aatgatagcc ggtattgcct     1020

gtcctctcgg ctgagagtgt ccgccacctt ttggcagaac ccccggaatc acttcagatg     1080

tcaggtgcag ttttacggcc tgtccgagaa cgatgagtgg acccaggacc gggccaagcc     1140

tgtgacacag atcgtgtctg ccgaggcatg gggaagagca gactgtggct tcacctctga     1200

gagctaccag cagggcgtgc tgagcgccac catcctgtat gagatcctgc tgggcaaggc     1260

cacactgtac gccgtcctgg tctccgctct ggtgctgatg gcaatggtca aaagaaaaga     1320

tagtcgggga cgggccaaga gatctggcag cggcgccacc aatttcagcc tgctgaaaca     1380

ggccggcgac gtggaagaga accctggccc catggagaag aatcccctgg ctgcccccct     1440

gctgatcctg tggtttcacc tggactgcgt gtcctctatc ctgaatgtgg aacagagccc     1500

acagagcctg cacgtgcagg agggcgactc caccaacttc acatgctctt ttcctagctc     1560

caacttctac gccctgcact ggtacagaaa ggagaccgca aagtccccag aggccctgtt     1620

cgtgatgaca ctgaacggcg atgagaagaa gaagggccgc atcagcgcca ccctgaatac     1680

aaaggagggc tactcctatc tgtacatcaa gggctcccag cctgaggact ctgccaccta     1740

tctgtgcgcc ctgtacaaca ataacgatat gcggtttggc gccggcacca gactgacagt     1800

gaagccaaac atccagaatc cagaccccgc cgtgtatcag ctgcgggaca gcaagtctag     1860

cgataagagc gtgtgcctgt tcaccgactt tgattctcag acaaacgtga gccagtccaa     1920

ggacagcgac gtgtacatca ccgacaagac agtgctggat atgagaagca tggacttcaa     1980

gtctaacagc gccgtggcct ggtccaataa gtctgatttc gcctgcgcca atgcctttaa     2040

taactccatc atccccgagg ataccttctt tccttctcca gagtcctctt gtgacgtgaa     2100

gctggtggag aagtctttcg agaccgatac aaacctgaat tttcagaacc tgagcgtgat     2160

cggcttcagg atcctgctgc tgaaggtggc cggctttaat ctgctgatga ccctgaggct     2220

gtggagctcc tgaaccggtc cgcagtctga cgtacgcgta atcaacctct ggattacaaa     2280

atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac     2340

gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc     2400

ttgtataaat cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt     2460

ggcgtggtgt gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc     2520

tgtcagctcc tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc     2580

gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg     2640

gtgttgtcgg ggaagctgac gtcctttcca tggctgctcg cctgtgttgc cacctggatt     2700

ctgcgcggga cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc     2760

cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt     2820

cggatctccc tttgggccgc ctccccgcc                                       2849


<210>  96
<211>  2531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 WPRE

<400>  96
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactcag cggccgcccc gggtcgacgc taccaccatg cgcccgagac tgtggcttct      420

gctcgccgcg caactgactg tcctgcacgg aaacagcgtg ctgcagcaga caccggccta      480

catcaaagtg cagaccaaca agatggtcat gctgtcctgc gaggccaaga tttccctctc      540

caacatgcgg atctattggt tgcggcagag acaggcgcct tcctcggact cccaccatga      600

gttcttggcc ctgtgggact ccgccaaggg aactattcac ggcgaagaag tggaacagga      660

gaagatcgcc gtgtttcgcg atgcctcccg ctttatactg aatctgacct ccgtgaagcc      720

cgaagatagc gggatctact tttgcatgat tgtgggctca cccgaactga ccttcgggaa      780

gggcactcag ctgagcgtgg tggacttcct ccccactacc gcccaaccca ctaagaagtc      840

aaccctgaag aagcgggttt gcagactccc acggccggaa acgcagaagg gtccgctgtg      900

ttccccgatc accctggggc tccttgtggc tggagtgctg gtccttctgg tgtcccttgg      960

cgtcgccatt cacctctgct gccggagaag gagggccaga ctgaggttca tgaagcagcc     1020

tcagggagag gggatcagtg gcactttcgt gccacaatgc ctccatggct actattccaa     1080

caccaccacc tcgcaaaagc tgctgaaccc ctggatcctg aaaacccggg ccaagagatc     1140

tggcagcggc gccaccaatt tcagcctgct gaaacaggcc ggcgacgtgg aagagaaccc     1200

tggccccatg gcgcttcccg tgaccgcact cctgttgccc cttgccctgc tgttgcacgc     1260

cgcacgacct tcccaattcc gggtgtcccc tctggatcgc acctggaacc tcggggaaac     1320

ggtggagctc aagtgtcaag tcctcctgtc gaacccgacc agcggatgca gctggctgtt     1380

ccagccgaga ggagctgccg cctcacccac cttcctcctg tacttgagcc agaacaagcc     1440

gaaggccgct gagggtctgg acacccagcg cttctcgggc aaacggctgg gagacacttt     1500

tgtgctgact ctctccgact tccggcggga gaacgagggc tactacttct gctctgcgct     1560

ctccaattca atcatgtact tctcacactt cgtgccggtg ttcctgcctg ccaagcccac     1620

cactactccg gcacccagac ctccaactcc cgctcccacc atcgcgtccc aacccctttc     1680

gctgcgccct gaagcgtgtc ggcctgctgc tggaggagcc gtgcataccc gcggtctgga     1740

cttcgcgtgc gacatctaca tttgggcccc tttggctggc acctgtggag tgctgctcct     1800

gtcccttgtg atcaccctgt actgcaacca ccggaatagg cggagagtct gcaagtgtcc     1860

gcggcctgtc gtgaagtcag gagataagcc gagcctgtcc gcacgctacg tgtgaaccgg     1920

tccgcagtct gacgtacgcg taatcaacct ctggattaca aaatttgtga aagattgact     1980

ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg     2040

tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg     2100

ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg     2160

tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct cctttccggg     2220

actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc     2280

tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg     2340

acgtcctttc catggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc     2400

tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct     2460

ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc     2520

gcctccccgc c                                                          2531


<210>  97
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RD114TR

<400>  97

Met Lys Leu Pro Thr Gly Met Val Ile Leu Cys Ser Leu Ile Ile Val 
1               5                   10                  15      


Arg Ala Gly Phe Asp Asp Pro Arg Lys Ala Ile Ala Leu Val Gln Lys 
            20                  25                  30          


Gln His Gly Lys Pro Cys Glu Cys Ser Gly Gly Gln Val Ser Glu Ala 
        35                  40                  45              


Pro Pro Asn Ser Ile Gln Gln Val Thr Cys Pro Gly Lys Thr Ala Tyr 
    50                  55                  60                  


Leu Met Thr Asn Gln Lys Trp Lys Cys Arg Val Thr Pro Lys Ile Ser 
65                  70                  75                  80  


Pro Ser Gly Gly Glu Leu Gln Asn Cys Pro Cys Asn Thr Phe Gln Asp 
                85                  90                  95      


Ser Met His Ser Ser Cys Tyr Thr Glu Tyr Arg Gln Cys Arg Arg Ile 
            100                 105                 110         


Asn Lys Thr Tyr Tyr Thr Ala Thr Leu Leu Lys Ile Arg Ser Gly Ser 
        115                 120                 125             


Leu Asn Glu Val Gln Ile Leu Gln Asn Pro Asn Gln Leu Leu Gln Ser 
    130                 135                 140                 


Pro Cys Arg Gly Ser Ile Asn Gln Pro Val Cys Trp Ser Ala Thr Ala 
145                 150                 155                 160 


Pro Ile His Ile Ser Asp Gly Gly Gly Pro Leu Asp Thr Lys Arg Val 
                165                 170                 175     


Trp Thr Val Gln Lys Arg Leu Glu Gln Ile His Lys Ala Met Thr Pro 
            180                 185                 190         


Glu Leu Gln Tyr His Pro Leu Ala Leu Pro Lys Val Arg Asp Asp Leu 
        195                 200                 205             


Ser Leu Asp Ala Arg Thr Phe Asp Ile Leu Asn Thr Thr Phe Arg Leu 
    210                 215                 220                 


Leu Gln Met Ser Asn Phe Ser Leu Ala Gln Asp Cys Trp Leu Cys Leu 
225                 230                 235                 240 


Lys Leu Gly Thr Pro Thr Pro Leu Ala Ile Pro Thr Pro Ser Leu Thr 
                245                 250                 255     


Tyr Ser Leu Ala Asp Ser Leu Ala Asn Ala Ser Cys Gln Ile Ile Pro 
            260                 265                 270         


Pro Leu Leu Val Gln Pro Met Gln Phe Ser Asn Ser Ser Cys Leu Ser 
        275                 280                 285             


Ser Pro Phe Ile Asn Asp Thr Glu Gln Ile Asp Leu Gly Ala Val Thr 
    290                 295                 300                 


Phe Thr Asn Cys Thr Ser Val Ala Asn Val Ser Ser Pro Leu Cys Ala 
305                 310                 315                 320 


Leu Asn Gly Ser Val Phe Leu Cys Gly Asn Asn Met Ala Tyr Thr Tyr 
                325                 330                 335     


Leu Pro Gln Asn Trp Thr Arg Leu Cys Val Gln Ala Ser Leu Leu Pro 
            340                 345                 350         


Asp Ile Asp Ile Asn Pro Gly Asp Glu Pro Val Pro Ile Pro Ala Ile 
        355                 360                 365             


Asp His Tyr Ile His Arg Pro Lys Arg Ala Val Gln Phe Ile Pro Leu 
    370                 375                 380                 


Leu Ala Gly Leu Gly Ile Thr Ala Ala Phe Thr Thr Gly Ala Thr Gly 
385                 390                 395                 400 


Leu Gly Val Ser Val Thr Gln Tyr Thr Lys Leu Ser His Gln Leu Ile 
                405                 410                 415     


Ser Asp Val Gln Val Leu Ser Gly Thr Ile Gln Asp Leu Gln Asp Gln 
            420                 425                 430         


Val Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp 
        435                 440                 445             


Leu Leu Thr Ala Glu Gln Gly Gly Ile Cys Leu Ala Leu Gln Glu Lys 
    450                 455                 460                 


Cys Cys Phe Tyr Ala Asn Lys Ser Gly Ile Val Arg Asn Lys Ile Arg 
465                 470                 475                 480 


Thr Leu Gln Glu Glu Leu Gln Lys Arg Arg Glu Ser Leu Ala Ser Asn 
                485                 490                 495     


Pro Leu Trp Thr Gly Leu Gln Gly Phe Leu Pro Tyr Leu Leu Pro Leu 
            500                 505                 510         


Leu Gly Pro Leu Leu Thr Leu Leu Leu Ile Leu Thr Ile Gly Pro Cys 
        515                 520                 525             


Val Phe Asn Arg Leu Val Gln Phe Val Lys Asp Arg Ile Ser Val Val 
    530                 535                 540                 


Gln Ala Leu Val Leu Thr Gln Gln Tyr His Gln Leu Lys Pro Leu 
545                 550                 555                 


<210>  98
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  98

Tyr Leu Tyr Asp Ser Glu Thr Lys Asn Ala 
1               5                   10  


<210>  99
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  99

His Leu Met Asp Gln Pro Leu Ser Val 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  100

Gly Leu Leu Lys Lys Ile Asn Ser Val 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  101

Phe Leu Val Asp Gly Ser Ser Ala Leu 
1               5                   


<210>  102
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  102

Phe Leu Phe Asp Gly Ser Ala Asn Leu Val 
1               5                   10  


<210>  103
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  103

Phe Leu Tyr Lys Ile Ile Asp Glu Leu 
1               5                   


<210>  104
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  104

Phe Ile Leu Asp Ser Ala Glu Thr Thr Thr Leu 
1               5                   10      


<210>  105
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  105

Ser Val Asp Val Ser Pro Pro Lys Val 
1               5                   


<210>  106
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  106

Val Ala Asp Lys Ile His Ser Val 
1               5               


<210>  107
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  107

Ile Val Asp Asp Leu Thr Ile Asn Leu 
1               5                   


<210>  108
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  108

Gly Leu Leu Glu Glu Leu Val Thr Val 
1               5                   


<210>  109
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  109

Thr Leu Asp Gly Ala Ala Val Asn Gln Val 
1               5                   10  


<210>  110
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  110

Ser Val Leu Glu Lys Glu Ile Tyr Ser Ile 
1               5                   10  


<210>  111
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  111

Leu Leu Asp Pro Lys Thr Ile Phe Leu 
1               5                   


<210>  112
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  112

Tyr Thr Phe Ser Gly Asp Val Gln Leu 
1               5                   


<210>  113
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  113

Tyr Leu Met Asp Asp Phe Ser Ser Leu 
1               5                   


<210>  114
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  114

Lys Val Trp Ser Asp Val Thr Pro Leu 
1               5                   


<210>  115
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  115

Leu Leu Trp Gly His Pro Arg Val Ala Leu Ala 
1               5                   10      


<210>  116
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  116

Lys Ile Trp Glu Glu Leu Ser Val Leu Glu Val 
1               5                   10      


<210>  117
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  117

Leu Leu Ile Pro Phe Thr Ile Phe Met 
1               5                   


<210>  118
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  118

Phe Leu Ile Glu Asn Leu Leu Ala Ala 
1               5                   


<210>  119
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  119

Leu Leu Trp Gly His Pro Arg Val Ala Leu Ala 
1               5                   10      


<210>  120
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  120

Phe Leu Leu Glu Arg Glu Gln Leu Leu 
1               5                   


<210>  121
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  121

Ser Leu Ala Glu Thr Ile Phe Ile Val 
1               5                   


<210>  122
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  122

Thr Leu Leu Glu Gly Ile Ser Arg Ala 
1               5                   


<210>  123
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  123

Lys Ile Gln Glu Ile Leu Thr Gln Val 
1               5                   


<210>  124
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  124

Val Ile Phe Glu Gly Glu Pro Met Tyr Leu 
1               5                   10  


<210>  125
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  125

Ser Leu Phe Glu Ser Leu Glu Tyr Leu 
1               5                   


<210>  126
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  126

Ser Leu Leu Asn Gln Pro Lys Ala Val 
1               5                   


<210>  127
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  127

Gly Leu Ala Glu Phe Gln Glu Asn Val 
1               5                   


<210>  128
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  128

Lys Leu Leu Ala Val Ile His Glu Leu 
1               5                   


<210>  129
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  129

Thr Leu His Asp Gln Val His Leu Leu 
1               5                   


<210>  130
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  130

Thr Leu Tyr Asn Pro Glu Arg Thr Ile Thr Val 
1               5                   10      


<210>  131
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  131

Lys Leu Gln Glu Lys Ile Gln Glu Leu 
1               5                   


<210>  132
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  132

Ser Val Leu Glu Lys Glu Ile Tyr Ser Ile 
1               5                   10  


<210>  133
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  133

Arg Val Ile Asp Asp Ser Leu Val Val Gly Val 
1               5                   10      


<210>  134
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  134

Val Leu Phe Gly Glu Leu Pro Ala Leu 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  135

Gly Leu Val Asp Ile Met Val His Leu 
1               5                   


<210>  136
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  136

Phe Leu Asn Ala Ile Glu Thr Ala Leu 
1               5                   


<210>  137
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  137

Ala Leu Leu Gln Ala Leu Met Glu Leu 
1               5                   


<210>  138
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  138

Ala Leu Ser Ser Ser Gln Ala Glu Val 
1               5                   


<210>  139
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  139

Ser Leu Ile Thr Gly Gln Asp Leu Leu Ser Val 
1               5                   10      


<210>  140
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  140

Gln Leu Ile Glu Lys Asn Trp Leu Leu 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  141

Leu Leu Asp Pro Lys Thr Ile Phe Leu 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  142

Arg Leu His Asp Glu Asn Ile Leu Leu 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  143

Tyr Thr Phe Ser Gly Asp Val Gln Leu 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  144

Gly Leu Pro Ser Ala Thr Thr Thr Val 
1               5                   


<210>  145
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  145

Gly Leu Leu Pro Ser Ala Glu Ser Ile Lys Leu 
1               5                   10      


<210>  146
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  146

Lys Thr Ala Ser Ile Asn Gln Asn Val 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  147

Ser Leu Leu Gln His Leu Ile Gly Leu 
1               5                   


<210>  148
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  148

Tyr Leu Met Asp Asp Phe Ser Ser Leu 
1               5                   


<210>  149
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  149

Leu Met Tyr Pro Tyr Ile Tyr His Val 
1               5                   


<210>  150
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  150

Lys Val Trp Ser Asp Val Thr Pro Leu 
1               5                   


<210>  151
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  151

Leu Leu Trp Gly His Pro Arg Val Ala Leu Ala 
1               5                   10      


<210>  152
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  152

Val Leu Asp Gly Lys Val Ala Val Val 
1               5                   


<210>  153
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  153

Gly Leu Leu Gly Lys Val Thr Ser Val 
1               5                   


<210>  154
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  154

Lys Met Ile Ser Ala Ile Pro Thr Leu 
1               5                   


<210>  155
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  155

Gly Leu Leu Glu Thr Thr Gly Leu Leu Ala Thr 
1               5                   10      


<210>  156
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  156

Thr Leu Asn Thr Leu Asp Ile Asn Leu 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  157

Val Ile Ile Lys Gly Leu Glu Glu Ile 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  158

Tyr Leu Glu Asp Gly Phe Ala Tyr Val 
1               5                   


<210>  159
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  159

Lys Ile Trp Glu Glu Leu Ser Val Leu Glu Val 
1               5                   10      


<210>  160
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  160

Leu Leu Ile Pro Phe Thr Ile Phe Met 
1               5                   


<210>  161
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  161

Ile Ser Leu Asp Glu Val Ala Val Ser Leu 
1               5                   10  


<210>  162
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  162

Lys Ile Ser Asp Phe Gly Leu Ala Thr Val 
1               5                   10  


<210>  163
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  163

Lys Leu Ile Gly Asn Ile His Gly Asn Glu Val 
1               5                   10      


<210>  164
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  164

Ile Leu Leu Ser Val Leu His Gln Leu 
1               5                   


<210>  165
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  165

Leu Asp Ser Glu Ala Leu Leu Thr Leu 
1               5                   


<210>  166
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  166

Val Leu Gln Glu Asn Ser Ser Asp Tyr Gln Ser Asn Leu 
1               5                   10              


<210>  167
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  167

His Leu Leu Gly Glu Gly Ala Phe Ala Gln Val 
1               5                   10      


<210>  168
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  168

Ser Leu Val Glu Asn Ile His Val Leu 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  169

Tyr Thr Phe Ser Gly Asp Val Gln Leu 
1               5                   


<210>  170
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  170

Ser Leu Ser Glu Lys Ser Pro Glu Val 
1               5                   


<210>  171
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  171

Ala Met Phe Pro Asp Thr Ile Pro Arg Val 
1               5                   10  


<210>  172
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  172

Phe Leu Ile Glu Asn Leu Leu Ala Ala 
1               5                   


<210>  173
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  173

Phe Thr Ala Glu Phe Leu Glu Lys Val 
1               5                   


<210>  174
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  174

Ala Leu Tyr Gly Asn Val Gln Gln Val 
1               5                   


<210>  175
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  175

Leu Phe Gln Ser Arg Ile Ala Gly Val 
1               5                   


<210>  176
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  176

Ile Leu Ala Glu Glu Pro Ile Tyr Ile Arg Val 
1               5                   10      


<210>  177
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  177

Phe Leu Leu Glu Arg Glu Gln Leu Leu 
1               5                   


<210>  178
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  178

Leu Leu Leu Pro Leu Glu Leu Ser Leu Ala 
1               5                   10  


<210>  179
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  179

Ser Leu Ala Glu Thr Ile Phe Ile Val 
1               5                   


<210>  180
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  180

Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val 
1               5                   10      


<210>  181
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  181

Arg Leu Phe Glu Glu Val Leu Gly Val 
1               5                   


<210>  182
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  182

Tyr Leu Asp Glu Val Ala Phe Met Leu 
1               5                   


<210>  183
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  183

Lys Leu Ile Asp Glu Asp Glu Pro Leu Phe Leu 
1               5                   10      


<210>  184
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  184

Lys Leu Phe Glu Lys Ser Thr Gly Leu 
1               5                   


<210>  185
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  185

Ser Leu Leu Glu Val Asn Glu Ala Ser Ser Val 
1               5                   10      


<210>  186
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  186

Gly Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  187
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  187

Gly Leu Tyr Pro Val Thr Leu Val Gly Val 
1               5                   10  


<210>  188
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  188

Ala Leu Leu Ser Ser Val Ala Glu Ala 
1               5                   


<210>  189
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  189

Thr Leu Leu Glu Gly Ile Ser Arg Ala 
1               5                   


<210>  190
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  190

Ser Leu Ile Glu Glu Ser Glu Glu Leu 
1               5                   


<210>  191
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  191

Ala Leu Tyr Val Gln Ala Pro Thr Val 
1               5                   


<210>  192
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  192

Lys Leu Ile Tyr Lys Asp Leu Val Ser Val 
1               5                   10  


<210>  193
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  193

Ile Leu Gln Asp Gly Gln Phe Leu Val 
1               5                   


<210>  194
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  194

Ser Leu Leu Asp Tyr Glu Val Ser Ile 
1               5                   


<210>  195
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  195

Leu Leu Gly Asp Ser Ser Phe Phe Leu 
1               5                   


<210>  196
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  196

Val Ile Phe Glu Gly Glu Pro Met Tyr Leu 
1               5                   10  


<210>  197
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  197

Ala Leu Ser Tyr Ile Leu Pro Tyr Leu 
1               5                   


<210>  198
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  198

Phe Leu Phe Val Asp Pro Glu Leu Val 
1               5                   


<210>  199
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  199

Ser Glu Trp Gly Ser Pro His Ala Ala Val Pro 
1               5                   10      


<210>  200
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  200

Ala Leu Ser Glu Leu Glu Arg Val Leu 
1               5                   


<210>  201
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  201

Ser Leu Phe Glu Ser Leu Glu Tyr Leu 
1               5                   


<210>  202
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  202

Lys Val Leu Glu Tyr Val Ile Lys Val 
1               5                   


<210>  203
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  203

Val Leu Leu Asn Glu Ile Leu Glu Gln Val 
1               5                   10  


<210>  204
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  204

Ser Leu Leu Asn Gln Pro Lys Ala Val 
1               5                   


<210>  205
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  205

Lys Met Ser Glu Leu Gln Thr Tyr Val 
1               5                   


<210>  206
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  206

Ala Leu Leu Glu Gln Thr Gly Asp Met Ser Leu 
1               5                   10      


<210>  207
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  207

Val Ile Ile Lys Gly Leu Glu Glu Ile Thr Val 
1               5                   10      


<210>  208
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  208

Lys Gln Phe Glu Gly Thr Val Glu Ile 
1               5                   


<210>  209
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  209

Lys Leu Gln Glu Glu Ile Pro Val Leu 
1               5                   


<210>  210
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  210

Gly Leu Ala Glu Phe Gln Glu Asn Val 
1               5                   


<210>  211
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  211

Asn Val Ala Glu Ile Val Ile His Ile 
1               5                   


<210>  212
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  212

Ala Leu Ala Gly Ile Val Thr Asn Val 
1               5                   


<210>  213
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  213

Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
1               5                   10          


<210>  214
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  214

Val Leu Met Gln Asp Ser Arg Leu Tyr Leu 
1               5                   10  


<210>  215
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  215

Lys Val Leu Glu His Val Val Arg Val 
1               5                   


<210>  216
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  216

Leu Leu Trp Gly Asn Leu Pro Glu Ile 
1               5                   


<210>  217
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  217

Ser Leu Met Glu Lys Asn Gln Ser Leu 
1               5                   


<210>  218
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  218

Lys Leu Leu Ala Val Ile His Glu Leu 
1               5                   


<210>  219
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  219

Ala Leu Gly Asp Lys Phe Leu Leu Arg Val 
1               5                   10  


<210>  220
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  220

Phe Leu Met Lys Asn Ser Asp Leu Tyr Gly Ala 
1               5                   10      


<210>  221
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  221

Lys Leu Ile Asp His Gln Gly Leu Tyr Leu 
1               5                   10  


<210>  222
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  222

Gly Pro Gly Ile Phe Pro Pro Pro Pro Pro Gln Pro 
1               5                   10          


<210>  223
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  223

Ala Leu Asn Glu Ser Leu Val Glu Cys 
1               5                   


<210>  224
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  224

Gly Leu Ala Ala Leu Ala Val His Leu 
1               5                   


<210>  225
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  225

Leu Leu Leu Glu Ala Val Trp His Leu 
1               5                   


<210>  226
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  226

Ser Ile Ile Glu Tyr Leu Pro Thr Leu 
1               5                   


<210>  227
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  227

Thr Leu His Asp Gln Val His Leu Leu 
1               5                   


<210>  228
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  228

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  229
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  229

Phe Leu Leu Asp Lys Pro Gln Asp Leu Ser Ile 
1               5                   10      


<210>  230
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  230

Tyr Leu Leu Asp Met Pro Leu Trp Tyr Leu 
1               5                   10  


<210>  231
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  231

Gly Leu Leu Asp Cys Pro Ile Phe Leu 
1               5                   


<210>  232
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  232

Val Leu Ile Glu Tyr Asn Phe Ser Ile 
1               5                   


<210>  233
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  233

Thr Leu Tyr Asn Pro Glu Arg Thr Ile Thr Val 
1               5                   10      


<210>  234
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  234

Ala Val Pro Pro Pro Pro Ser Ser Val 
1               5                   


<210>  235
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  235

Lys Leu Gln Glu Glu Leu Asn Lys Val 
1               5                   


<210>  236
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  236

Lys Leu Met Asp Pro Gly Ser Leu Pro Pro Leu 
1               5                   10      


<210>  237
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  237

Ala Leu Ile Val Ser Leu Pro Tyr Leu 
1               5                   


<210>  238
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  238

Phe Leu Leu Asp Gly Ser Ala Asn Val 
1               5                   


<210>  239
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  239

Ala Leu Asp Pro Ser Gly Asn Gln Leu Ile 
1               5                   10  


<210>  240
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  240

Ile Leu Ile Lys His Leu Val Lys Val 
1               5                   


<210>  241
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  241

Val Leu Leu Asp Thr Ile Leu Gln Leu 
1               5                   


<210>  242
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  242

His Leu Ile Ala Glu Ile His Thr Ala 
1               5                   


<210>  243
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  243

Ser Met Asn Gly Gly Val Phe Ala Val 
1               5                   


<210>  244
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Leu Ala Glu Lys Leu Leu Gln Ala 
1               5                   


<210>  245
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  245

Tyr Met Leu Asp Ile Phe His Glu Val 
1               5                   


<210>  246
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  246

Ala Leu Trp Leu Pro Thr Asp Ser Ala Thr Val 
1               5                   10      


<210>  247
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  247

Gly Leu Ala Ser Arg Ile Leu Asp Ala 
1               5                   


<210>  248
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  248

Ala Leu Ser Val Leu Arg Leu Ala Leu 
1               5                   


<210>  249
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  249

Ser Tyr Val Lys Val Leu His His Leu 
1               5                   


<210>  250
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  250

Val Tyr Leu Pro Lys Ile Pro Ser Trp 
1               5                   


<210>  251
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  251

Asn Tyr Glu Asp His Phe Pro Leu Leu 
1               5                   


<210>  252
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  252

Val Tyr Ile Ala Glu Leu Glu Lys Ile 
1               5                   


<210>  253
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  253

Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe 
1               5                   10          


<210>  254
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  254

Val Leu Ser Pro Phe Ile Leu Thr Leu 
1               5                   


<210>  255
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  255

His Leu Leu Glu Gly Ser Val Gly Val 
1               5                   


<210>  256
<211>  3658
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8aCD4Fusion.TCR.WPRE

<400>  256
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactagc ggccgccccg ggtcgacgct accaccatgg cgcttcccgt gaccgcactc      420

ctgttgcccc ttgccctgct gttgcacgcc gcacgacctt cccaattccg ggtgtcccct      480

ctggatcgca cctggaacct cggggaaacg gtggagctca agtgtcaagt cctcctgtcg      540

aacccgacca gcggatgcag ctggctgttc cagccgagag gagctgccgc ctcacccacc      600

ttcctcctgt acttgagcca gaacaagccg aaggccgctg agggtctgga cacccagcgc      660

ttctcgggca aacggctggg agacactttt gtgctgactc tctccgactt ccggcgggag      720

aacgagggct actacttctg ctctgcgctc tccaattcaa tcatgtactt ctcacacttc      780

gtgccggtgt tcctgcctgc caagcccacc actactccgg cacccagacc tccaactccc      840

gctcccacca tcgcgtccca acccctttcg ctgcgccctg aagcgtgtcg gcctgctgct      900

ggaggagccg tgcatacccg cggtctggac ttcgcgtgcg acatggccct gattgtgctg      960

gggggcgtcg ccggcctcct gcttttcatt gggctaggca tcttcttctg tgtcaggtgc     1020

cggcaccgaa ggcgccaagc agagcggatg tctcagatca agagactcct cagtgagaag     1080

aagacctgcc agtgtcctca ccggtttcag aagacatgta gccccattcg ggccaagaga     1140

tctggcagcg gcgccaccaa tttcagcctg ctgaaacagg ccggcgacgt ggaagagaac     1200

cctggcccca tggactcttg gaccttctgc tgcgtgagcc tgtgcatcct ggtggccaag     1260

cacacagacg ccggcgtgat ccagtcccct aggcacgagg tgaccgagat gggccaggag     1320

gtgacactgc gctgtaagcc aatctctggc cacaacagcc tgttttggta tagggagacc     1380

atgatgcgcg gcctggagct gctgatctac ttcaataaca atgtgcccat cgacgattcc     1440

ggcatgcctg aggatcggtt ttctgccaag atgcccaatg ccagcttctc cacactgaag     1500

atccagccta gcgagccaag agactccgcc gtgtattttt gcgcctctag cccaggcagc     1560

accgatacac agtacttcgg accaggaacc aggctgacag tgctggagga cctgaagaac     1620

gtgttccccc ctgaggtggc cgtgtttgag ccctctgagg ccgagatcag ccacacccag     1680

aaggccaccc tggtgtgcct ggcaaccggc ttctatcctg atcacgtgga gctgtcctgg     1740

tgggtgaacg gcaaggaggt gcacagcggc gtgtccacag acccacagcc cctgaaggag     1800

cagccagccc tgaatgatag ccggtattgc ctgtcctctc ggctgagagt gtccgccacc     1860

ttttggcaga acccccggaa tcacttcaga tgtcaggtgc agttttacgg cctgtccgag     1920

aacgatgagt ggacccagga ccgggccaag cctgtgacac agatcgtgtc tgccgaggca     1980

tggggaagag cagactgtgg cttcacctct gagagctacc agcagggcgt gctgagcgcc     2040

accatcctgt atgagatcct gctgggcaag gccacactgt acgccgtcct ggtctccgct     2100

ctggtgctga tggcaatggt caaaagaaaa gatagtcggg gacgggccaa gagatctggc     2160

agcggcgagg gcagaggcag cctgctgacc tgcggcgacg tggaggagaa ccccggcccc     2220

atggagaaga atcccctggc tgcccccctg ctgatcctgt ggtttcacct ggactgcgtg     2280

tcctctatcc tgaatgtgga acagagccca cagagcctgc acgtgcagga gggcgactcc     2340

accaacttca catgctcttt tcctagctcc aacttctacg ccctgcactg gtacagaaag     2400

gagaccgcaa agtccccaga ggccctgttc gtgatgacac tgaacggcga tgagaagaag     2460

aagggccgca tcagcgccac cctgaataca aaggagggct actcctatct gtacatcaag     2520

ggctcccagc ctgaggactc tgccacctat ctgtgcgccc tgtacaacaa taacgatatg     2580

cggtttggcg ccggcaccag actgacagtg aagccaaaca tccagaatcc agaccccgcc     2640

gtgtatcagc tgcgggacag caagtctagc gataagagcg tgtgcctgtt caccgacttt     2700

gattctcaga caaacgtgag ccagtccaag gacagcgacg tgtacatcac cgacaagaca     2760

gtgctggata tgagaagcat ggacttcaag tctaacagcg ccgtggcctg gtccaataag     2820

tctgatttcg cctgcgccaa tgcctttaat aactccatca tccccgagga taccttcttt     2880

ccttctccag agtcctcttg tgacgtgaag ctggtggaga agtctttcga gaccgataca     2940

aacctgaatt ttcagaacct gagcgtgatc ggcttcagga tcctgctgct gaaggtggcc     3000

ggctttaatc tgctgatgac cctgaggctg tggagctcct gaaccggtcc gcagtctgac     3060

gtacgcgtaa tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact     3120

atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg     3180

cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg     3240

aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa     3300

cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc     3360

ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg     3420

ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaagctgacg tcctttccat     3480

ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt     3540

cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc     3600

cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcc       3658


<210>  257
<211>  3622
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8bCD4Fusion.TCR.WPRE

<400>  257
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactagc ggccgccccg ggtcgacgct accaccatgc gcccgagact gtggcttctg      420

ctcgccgcgc aactgactgt cctgcacgga aacagcgtgc tgcagcagac accggcctac      480

atcaaagtgc agaccaacaa gatggtcatg ctgtcctgcg aggccaagat ttccctctcc      540

aacatgcgga tctattggtt gcggcagaga caggcgcctt cctcggactc ccaccatgag      600

ttcttggccc tgtgggactc cgccaaggga actattcacg gcgaagaagt ggaacaggag      660

aagatcgccg tgtttcgcga tgcctcccgc tttatactga atctgacctc cgtgaagccc      720

gaagatagcg ggatctactt ttgcatgatt gtgggctcac ccgaactgac cttcgggaag      780

ggcactcagc tgagcgtggt ggacttcctc cccactaccg cccaacccac taagaagtca      840

accctgaaga agcgggtttg cagactccca cggccggaaa cgcagaaggg tccgctgtgt      900

tccccgatgg ccctgattgt gctggggggc gtcgccggcc tcctgctttt cattgggcta      960

ggcatcttct tctgtgtcag gtgccggcac cgaaggcgcc aagcagagcg gatgtctcag     1020

atcaagagac tcctcagtga gaagaagacc tgccagtgtc ctcaccggtt tcagaagaca     1080

tgtagcccca ttcgggccaa gagatctggc agcggcgcca ccaatttcag cctgctgaaa     1140

caggccggcg acgtggaaga gaaccctggc cccatggact cttggacctt ctgctgcgtg     1200

agcctgtgca tcctggtggc caagcacaca gacgccggcg tgatccagtc ccctaggcac     1260

gaggtgaccg agatgggcca ggaggtgaca ctgcgctgta agccaatctc tggccacaac     1320

agcctgtttt ggtataggga gaccatgatg cgcggcctgg agctgctgat ctacttcaat     1380

aacaatgtgc ccatcgacga ttccggcatg cctgaggatc ggttttctgc caagatgccc     1440

aatgccagct tctccacact gaagatccag cctagcgagc caagagactc cgccgtgtat     1500

ttttgcgcct ctagcccagg cagcaccgat acacagtact tcggaccagg aaccaggctg     1560

acagtgctgg aggacctgaa gaacgtgttc ccccctgagg tggccgtgtt tgagccctct     1620

gaggccgaga tcagccacac ccagaaggcc accctggtgt gcctggcaac cggcttctat     1680

cctgatcacg tggagctgtc ctggtgggtg aacggcaagg aggtgcacag cggcgtgtcc     1740

acagacccac agcccctgaa ggagcagcca gccctgaatg atagccggta ttgcctgtcc     1800

tctcggctga gagtgtccgc caccttttgg cagaaccccc ggaatcactt cagatgtcag     1860

gtgcagtttt acggcctgtc cgagaacgat gagtggaccc aggaccgggc caagcctgtg     1920

acacagatcg tgtctgccga ggcatgggga agagcagact gtggcttcac ctctgagagc     1980

taccagcagg gcgtgctgag cgccaccatc ctgtatgaga tcctgctggg caaggccaca     2040

ctgtacgccg tcctggtctc cgctctggtg ctgatggcaa tggtcaaaag aaaagatagt     2100

cggggacggg ccaagagatc tggcagcggc gagggcagag gcagcctgct gacctgcggc     2160

gacgtggagg agaaccccgg ccccatggag aagaatcccc tggctgcccc cctgctgatc     2220

ctgtggtttc acctggactg cgtgtcctct atcctgaatg tggaacagag cccacagagc     2280

ctgcacgtgc aggagggcga ctccaccaac ttcacatgct cttttcctag ctccaacttc     2340

tacgccctgc actggtacag aaaggagacc gcaaagtccc cagaggccct gttcgtgatg     2400

acactgaacg gcgatgagaa gaagaagggc cgcatcagcg ccaccctgaa tacaaaggag     2460

ggctactcct atctgtacat caagggctcc cagcctgagg actctgccac ctatctgtgc     2520

gccctgtaca acaataacga tatgcggttt ggcgccggca ccagactgac agtgaagcca     2580

aacatccaga atccagaccc cgccgtgtat cagctgcggg acagcaagtc tagcgataag     2640

agcgtgtgcc tgttcaccga ctttgattct cagacaaacg tgagccagtc caaggacagc     2700

gacgtgtaca tcaccgacaa gacagtgctg gatatgagaa gcatggactt caagtctaac     2760

agcgccgtgg cctggtccaa taagtctgat ttcgcctgcg ccaatgcctt taataactcc     2820

atcatccccg aggatacctt ctttccttct ccagagtcct cttgtgacgt gaagctggtg     2880

gagaagtctt tcgagaccga tacaaacctg aattttcaga acctgagcgt gatcggcttc     2940

aggatcctgc tgctgaaggt ggccggcttt aatctgctga tgaccctgag gctgtggagc     3000

tcctgaaccg gtccgcagtc tgacgtacgc gtaatcaacc tctggattac aaaatttgtg     3060

aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt     3120

taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata     3180

aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg     3240

tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc     3300

tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct     3360

gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt     3420

cggggaagct gacgtccttt ccatggctgc tcgcctgtgt tgccacctgg attctgcgcg     3480

ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc     3540

tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct     3600

ccctttgggc cgcctccccg cc                                              3622


<210>  258
<211>  3595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8bCD8aFusion.TCR.WPRE

<400>  258
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt      300

cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc      360

cctcactagc ggccgccccg ggtcgacgct accaccatgc gcccgagact gtggcttctg      420

ctcgccgcgc aactgactgt cctgcacgga aacagcgtgc tgcagcagac accggcctac      480

atcaaagtgc agaccaacaa gatggtcatg ctgtcctgcg aggccaagat ttccctctcc      540

aacatgcgga tctattggtt gcggcagaga caggcgcctt cctcggactc ccaccatgag      600

ttcttggccc tgtgggactc cgccaaggga actattcacg gcgaagaagt ggaacaggag      660

aagatcgccg tgtttcgcga tgcctcccgc tttatactga atctgacctc cgtgaagccc      720

gaagatagcg ggatctactt ttgcatgatt gtgggctcac ccgaactgac cttcgggaag      780

ggcactcagc tgagcgtggt ggacttcctc cccactaccg cccaacccac taagaagtca      840

accctgaaga agcgggtttg cagactccca cggccggaaa cgcagaaggg tccgctgtgt      900

tccccgatct acatttgggc ccctttggct ggcacctgtg gagtgctgct cctgtccctt      960

gtgatcaccc tgtactgcaa ccaccggaat aggcggagag tctgcaagtg tccgcggcct     1020

gtcgtgaagt caggagataa gccgagcctg tccgcacgct acgtgcgggc caagagatct     1080

ggcagcggcg ccaccaattt cagcctgctg aaacaggccg gcgacgtgga agagaaccct     1140

ggccccatgg actcttggac cttctgctgc gtgagcctgt gcatcctggt ggccaagcac     1200

acagacgccg gcgtgatcca gtcccctagg cacgaggtga ccgagatggg ccaggaggtg     1260

acactgcgct gtaagccaat ctctggccac aacagcctgt tttggtatag ggagaccatg     1320

atgcgcggcc tggagctgct gatctacttc aataacaatg tgcccatcga cgattccggc     1380

atgcctgagg atcggttttc tgccaagatg cccaatgcca gcttctccac actgaagatc     1440

cagcctagcg agccaagaga ctccgccgtg tatttttgcg cctctagccc aggcagcacc     1500

gatacacagt acttcggacc aggaaccagg ctgacagtgc tggaggacct gaagaacgtg     1560

ttcccccctg aggtggccgt gtttgagccc tctgaggccg agatcagcca cacccagaag     1620

gccaccctgg tgtgcctggc aaccggcttc tatcctgatc acgtggagct gtcctggtgg     1680

gtgaacggca aggaggtgca cagcggcgtg tccacagacc cacagcccct gaaggagcag     1740

ccagccctga atgatagccg gtattgcctg tcctctcggc tgagagtgtc cgccaccttt     1800

tggcagaacc cccggaatca cttcagatgt caggtgcagt tttacggcct gtccgagaac     1860

gatgagtgga cccaggaccg ggccaagcct gtgacacaga tcgtgtctgc cgaggcatgg     1920

ggaagagcag actgtggctt cacctctgag agctaccagc agggcgtgct gagcgccacc     1980

atcctgtatg agatcctgct gggcaaggcc acactgtacg ccgtcctggt ctccgctctg     2040

gtgctgatgg caatggtcaa aagaaaagat agtcggggac gggccaagag atctggcagc     2100

ggcgagggca gaggcagcct gctgacctgc ggcgacgtgg aggagaaccc cggccccatg     2160

gagaagaatc ccctggctgc ccccctgctg atcctgtggt ttcacctgga ctgcgtgtcc     2220

tctatcctga atgtggaaca gagcccacag agcctgcacg tgcaggaggg cgactccacc     2280

aacttcacat gctcttttcc tagctccaac ttctacgccc tgcactggta cagaaaggag     2340

accgcaaagt ccccagaggc cctgttcgtg atgacactga acggcgatga gaagaagaag     2400

ggccgcatca gcgccaccct gaatacaaag gagggctact cctatctgta catcaagggc     2460

tcccagcctg aggactctgc cacctatctg tgcgccctgt acaacaataa cgatatgcgg     2520

tttggcgccg gcaccagact gacagtgaag ccaaacatcc agaatccaga ccccgccgtg     2580

tatcagctgc gggacagcaa gtctagcgat aagagcgtgt gcctgttcac cgactttgat     2640

tctcagacaa acgtgagcca gtccaaggac agcgacgtgt acatcaccga caagacagtg     2700

ctggatatga gaagcatgga cttcaagtct aacagcgccg tggcctggtc caataagtct     2760

gatttcgcct gcgccaatgc ctttaataac tccatcatcc ccgaggatac cttctttcct     2820

tctccagagt cctcttgtga cgtgaagctg gtggagaagt ctttcgagac cgatacaaac     2880

ctgaattttc agaacctgag cgtgatcggc ttcaggatcc tgctgctgaa ggtggccggc     2940

tttaatctgc tgatgaccct gaggctgtgg agctcctgaa ccggtccgca gtctgacgta     3000

cgcgtaatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg     3060

ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt     3120

cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg     3180

agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc     3240

ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc     3300

tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc     3360

ggctgttggg cactgacaat tccgtggtgt tgtcggggaa gctgacgtcc tttccatggc     3420

tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg     3480

ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc     3540

gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgcc          3595


<210>  259
<211>  5091
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGK.CD8.EF1a.TCR

<400>  259
tcacacgtag cgtgcggaca ggctcggctt atctcctgac ttcacgacag gccgcggaca       60

cttgcagact ctccgcctat tccggtggtt gcagtacagg gtgatcacaa gggacaggag      120

cagcactcca caggtgccag ccaaaggggc ccaaatgtag atgtcgcacg cgaagtccag      180

accgcgggta tgcacggctc ctccagcagc aggccgacac gcttcagggc gcagcgaaag      240

gggttgggac gcgatggtgg gagcgggagt tggaggtctg ggtgccggag tagtggtggg      300

cttggcaggc aggaacaccg gcacgaagtg tgagaagtac atgattgaat tggagagcgc      360

agagcagaag tagtagccct cgttctcccg ccggaagtcg gagagagtca gcacaaaagt      420

gtctcccagc cgtttgcccg agaagcgctg ggtgtccaga ccctcagcgg ccttcggctt      480

gttctggctc aagtacagga ggaaggtggg tgaggcggca gctcctctcg gctggaacag      540

ccagctgcat ccgctggtcg ggttcgacag gaggacttga cacttgagct ccaccgtttc      600

cccgaggttc caggtgcgat ccagagggga cacccggaat tgggaaggtc gtgcggcgtg      660

caacagcagg gcaaggggca acaggagtgc ggtcacggga agcgccatgg ggccagggtt      720

ctcttccacg tcgccggcct gtttcagcag gctgaaattg gtggcgccgc tgccagatct      780

cttggcccgg gttttcagga tccaggggtt cagcagcttt tgcgaggtgg tggtgttgga      840

atagtagcca tggaggcact gtggcacgaa agtgccactg atcccctctc cctgaggctg      900

cttcatgaac ctcagtctgg ccctccttct ccggcagcag aggtgaatgg cgacgccaag      960

ggacaccaga aggaccagca ctccagccac aaggagcccc agggtgatcg gggaacacag     1020

cggacccttc tgcgtttccg gccgtgggag tctgcaaacc cgcttcttca gggttgactt     1080

cttagtgggt tgggcggtag tggggaggaa gtccaccacg ctcagctgag tgcccttccc     1140

gaaggtcagt tcgggtgagc ccacaatcat gcaaaagtag atcccgctat cttcgggctt     1200

cacggaggtc agattcagta taaagcggga ggcatcgcga aacacggcga tcttctcctg     1260

ttccacttct tcgccgtgaa tagttccctt ggcggagtcc cacagggcca agaactcatg     1320

gtgggagtcc gaggaaggcg cctgtctctg ccgcaaccaa tagatccgca tgttggagag     1380

ggaaatcttg gcctcgcagg acagcatgac catcttgttg gtctgcactt tgatgtaggc     1440

cggtgtctgc tgcagcacgc tgtttccgtg caggacagtc agttgcgcgg cgagcagaag     1500

ccacagtctc gggcgcatgg tggtagcgtc gacccggggc ggccgctcga aaggcccgga     1560

gatgaggaag aggagaacag cgcggcagac gtgcgctttt gaagcgtgca gaatgccggg     1620

cctccggagg accttcgggc gcccgccccg cccctgagcc cgcccctgag cccgcccccg     1680

gacccacccc ttcccagcct ctgagcccag aaagcgaagg agcaaagctg ctattggccg     1740

ctgccccaaa ggcctacccg cttccagtgc tcagcggtgc tgtccatctg cacgagacta     1800

gtgagacgtg ctacttccat ttgtcacgtc ctgcacgacg cgagctgcgg ggcggggggg     1860

aacttcctga ctaggggagg agtagaaggt ggcgcgaagg ggccaccaaa gaacggagcc     1920

ggttggcgcc taccggtgga tgtggaatgt gtgcgaggcc agaggccact tgtgtagcgc     1980

caagtgccca gcggggctgc taaagcgcat gctccagact gccttgggaa aagcgcctcc     2040

cctacccgct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag     2100

ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg ggtaaactgg     2160

gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata     2220

agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacaggta     2280

agtgccgtgt gtggttcccg cgggcctggc ctctttacgg gttatggccc ttgcgtgcct     2340

tgaattactt ccacgcccct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg     2400

aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt     2460

tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg     2520

tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct     2580

ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt     2640

ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg     2700

gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc     2760

tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg     2820

gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc     2880

aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag     2940

ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag     3000

gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt     3060

ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca     3120

cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa     3180

gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgaa gcggccgccc     3240

cgggtcgacg ctaccaccat ggactcttgg accttctgct gcgtgagcct gtgcatcctg     3300

gtggccaagc acacagacgc cggcgtgatc cagtccccta ggcacgaggt gaccgagatg     3360

ggccaggagg tgacactgcg ctgtaagcca atctctggcc acaacagcct gttttggtat     3420

agggagacca tgatgcgcgg cctggagctg ctgatctact tcaataacaa tgtgcccatc     3480

gacgattccg gcatgcctga ggatcggttt tctgccaaga tgcccaatgc cagcttctcc     3540

acactgaaga tccagcctag cgagccaaga gactccgccg tgtatttttg cgcctctagc     3600

ccaggcagca ccgatacaca gtacttcgga ccaggaacca ggctgacagt gctggaggac     3660

ctgaagaacg tgttcccccc tgaggtggcc gtgtttgagc cctctgaggc cgagatcagc     3720

cacacccaga aggccaccct ggtgtgcctg gcaaccggct tctatcctga tcacgtggag     3780

ctgtcctggt gggtgaacgg caaggaggtg cacagcggcg tgtccacaga cccacagccc     3840

ctgaaggagc agccagccct gaatgatagc cggtattgcc tgtcctctcg gctgagagtg     3900

tccgccacct tttggcagaa cccccggaat cacttcagat gtcaggtgca gttttacggc     3960

ctgtccgaga acgatgagtg gacccaggac cgggccaagc ctgtgacaca gatcgtgtct     4020

gccgaggcat ggggaagagc agactgtggc ttcacctctg agagctacca gcagggcgtg     4080

ctgagcgcca ccatcctgta tgagatcctg ctgggcaagg ccacactgta cgccgtcctg     4140

gtctccgctc tggtgctgat ggcaatggtc aaaagaaaag atagtcgggg acgggccaag     4200

agatctggca gcggcgaggg cagaggcagc ctgctgacct gcggcgacgt ggaggagaac     4260

cccggcccca tggagaagaa tcccctggct gcccccctgc tgatcctgtg gtttcacctg     4320

gactgcgtgt cctctatcct gaatgtggaa cagagcccac agagcctgca cgtgcaggag     4380

ggcgactcca ccaacttcac atgctctttt cctagctcca acttctacgc cctgcactgg     4440

tacagaaagg agaccgcaaa gtccccagag gccctgttcg tgatgacact gaacggcgat     4500

gagaagaaga agggccgcat cagcgccacc ctgaatacaa aggagggcta ctcctatctg     4560

tacatcaagg gctcccagcc tgaggactct gccacctatc tgtgcgccct gtacaacaat     4620

aacgatatgc ggtttggcgc cggcaccaga ctgacagtga agccaaacat ccagaatcca     4680

gaccccgccg tgtatcagct gcgggacagc aagtctagcg ataagagcgt gtgcctgttc     4740

accgactttg attctcagac aaacgtgagc cagtccaagg acagcgacgt gtacatcacc     4800

gacaagacag tgctggatat gagaagcatg gacttcaagt ctaacagcgc cgtggcctgg     4860

tccaataagt ctgatttcgc ctgcgccaat gcctttaata actccatcat ccccgaggat     4920

accttctttc cttctccaga gtcctcttgt gacgtgaagc tggtggagaa gtctttcgag     4980

accgatacaa acctgaattt tcagaacctg agcgtgatcg gcttcaggat cctgctgctg     5040

aaggtggccg gctttaatct gctgatgacc ctgaggctgt ggagctcctg a              5091


<210>  260
<211>  5091
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGK.TCR.EF1a.CD8

<400>  260
tcaggagctc cacagcctca gggtcatcag cagattaaag ccggccacct tcagcagcag       60

gatcctgaag ccgatcacgc tcaggttctg aaaattcagg tttgtatcgg tctcgaaaga      120

cttctccacc agcttcacgt cacaagagga ctctggagaa ggaaagaagg tatcctcggg      180

gatgatggag ttattaaagg cattggcgca ggcgaaatca gacttattgg accaggccac      240

ggcgctgtta gacttgaagt ccatgcttct catatccagc actgtcttgt cggtgatgta      300

cacgtcgctg tccttggact ggctcacgtt tgtctgagaa tcaaagtcgg tgaacaggca      360

cacgctctta tcgctagact tgctgtcccg cagctgatac acggcggggt ctggattctg      420

gatgtttggc ttcactgtca gtctggtgcc ggcgccaaac cgcatatcgt tattgttgta      480

cagggcgcac agataggtgg cagagtcctc aggctgggag cccttgatgt acagatagga      540

gtagccctcc tttgtattca gggtggcgct gatgcggccc ttcttcttct catcgccgtt      600

cagtgtcatc acgaacaggg cctctgggga ctttgcggtc tcctttctgt accagtgcag      660

ggcgtagaag ttggagctag gaaaagagca tgtgaagttg gtggagtcgc cctcctgcac      720

gtgcaggctc tgtgggctct gttccacatt caggatagag gacacgcagt ccaggtgaaa      780

ccacaggatc agcagggggg cagccagggg attcttctcc atggggccgg ggttctcctc      840

cacgtcgccg caggtcagca ggctgcctct gccctcgccg ctgccagatc tcttggcccg      900

tccccgacta tcttttcttt tgaccattgc catcagcacc agagcggaga ccaggacggc      960

gtacagtgtg gccttgccca gcaggatctc atacaggatg gtggcgctca gcacgccctg     1020

ctggtagctc tcagaggtga agccacagtc tgctcttccc catgcctcgg cagacacgat     1080

ctgtgtcaca ggcttggccc ggtcctgggt ccactcatcg ttctcggaca ggccgtaaaa     1140

ctgcacctga catctgaagt gattccgggg gttctgccaa aaggtggcgg acactctcag     1200

ccgagaggac aggcaatacc ggctatcatt cagggctggc tgctccttca ggggctgtgg     1260

gtctgtggac acgccgctgt gcacctcctt gccgttcacc caccaggaca gctccacgtg     1320

atcaggatag aagccggttg ccaggcacac cagggtggcc ttctgggtgt ggctgatctc     1380

ggcctcagag ggctcaaaca cggccacctc aggggggaac acgttcttca ggtcctccag     1440

cactgtcagc ctggttcctg gtccgaagta ctgtgtatcg gtgctgcctg ggctagaggc     1500

gcaaaaatac acggcggagt ctcttggctc gctaggctgg atcttcagtg tggagaagct     1560

ggcattgggc atcttggcag aaaaccgatc ctcaggcatg ccggaatcgt cgatgggcac     1620

attgttattg aagtagatca gcagctccag gccgcgcatc atggtctccc tataccaaaa     1680

caggctgttg tggccagaga ttggcttaca gcgcagtgtc acctcctggc ccatctcggt     1740

cacctcgtgc ctaggggact ggatcacgcc ggcgtctgtg tgcttggcca ccaggatgca     1800

caggctcacg cagcagaagg tccaagagtc catggtggta gcgtcgaccc ggggcggccg     1860

ctcgaaaggc ccggagatga ggaagaggag aacagcgcgg cagacgtgcg cttttgaagc     1920

gtgcagaatg ccgggcctcc ggaggacctt cgggcgcccg ccccgcccct gagcccgccc     1980

ctgagcccgc ccccggaccc accccttccc agcctctgag cccagaaagc gaaggagcaa     2040

agctgctatt ggccgctgcc ccaaaggcct acccgcttcc agtgctcagc ggtgctgtcc     2100

atctgcacga gactagtgag acgtgctact tccatttgtc acgtcctgca cgacgcgagc     2160

tgcggggcgg gggggaactt cctgactagg ggaggagtag aaggtggcgc gaaggggcca     2220

ccaaagaacg gagccggttg gcgcctaccg gtggatgtgg aatgtgtgcg aggccagagg     2280

ccacttgtgt agcgccaagt gcccagcggg gctgctaaag cgcatgctcc agactgcctt     2340

gggaaaagcg cctcccctac ccgctccggt gcccgtcagt gggcagagcg cacatcgccc     2400

acagtccccg agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg     2460

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     2520

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     2580

gccagaacac aggtaagtgc cgtgtgtggt tcccgcgggc ctggcctctt tacgggttat     2640

ggcccttgcg tgccttgaat tacttccacg cccctggctg cagtacgtga ttcttgatcc     2700

cgagcttcgg gttggaagtg ggtgggagag ttcgaggcct tgcgcttaag gagccccttc     2760

gcctcgtgct tgagttgagg cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg     2820

gcaccttcgc gcctgtctcg ctgctttcga taagtctcta gccatttaaa atttttgatg     2880

acctgctgcg acgctttttt tctggcaaga tagtcttgta aatgcgggcc aagatctgca     2940

cactggtatt tcggtttttg gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac     3000

atgttcggcg aggcggggcc tgcgagcgcg gccaccgaga atcggacggg ggtagtctca     3060

agctggccgg cctgctctgg tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc     3120

ggcaaggctg gcccggtcgg caccagttgc gtgagcggaa agatggccgc ttcccggccc     3180

tgctgcaggg agctcaaaat ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc     3240

cacacaaagg aaaagggcct ttccgtcctc agccgtcgct tcatgtgact ccacggagta     3300

ccgggcgccg tccaggcacc tcgattagtt ctcgagcttt tggagtacgt cgtctttagg     3360

ttggggggag gggttttatg cgatggagtt tccccacact gagtgggtgg agactgaagt     3420

taggccagct tggcacttga tgtaattctc cttggaattt gccctttttg agtttggatc     3480

ttggttcatt ctcaagcctc agacagtggt tcaaagtttt tttcttccat ttcaggtgtc     3540

gtgaagcggc cgccccgggt cgacgctacc accatgcgcc cgagactgtg gcttctgctc     3600

gccgcgcaac tgactgtcct gcacggaaac agcgtgctgc agcagacacc ggcctacatc     3660

aaagtgcaga ccaacaagat ggtcatgctg tcctgcgagg ccaagatttc cctctccaac     3720

atgcggatct attggttgcg gcagagacag gcgccttcct cggactccca ccatgagttc     3780

ttggccctgt gggactccgc caagggaact attcacggcg aagaagtgga acaggagaag     3840

atcgccgtgt ttcgcgatgc ctcccgcttt atactgaatc tgacctccgt gaagcccgaa     3900

gatagcggga tctacttttg catgattgtg ggctcacccg aactgacctt cgggaagggc     3960

actcagctga gcgtggtgga cttcctcccc actaccgccc aacccactaa gaagtcaacc     4020

ctgaagaagc gggtttgcag actcccacgg ccggaaacgc agaagggtcc gctgtgttcc     4080

ccgatcaccc tggggctcct tgtggctgga gtgctggtcc ttctggtgtc ccttggcgtc     4140

gccattcacc tctgctgccg gagaaggagg gccagactga ggttcatgaa gcagcctcag     4200

ggagagggga tcagtggcac tttcgtgcca cagtgcctcc atggctacta ttccaacacc     4260

accacctcgc aaaagctgct gaacccctgg atcctgaaaa cccgggccaa gagatctggc     4320

agcggcgcca ccaatttcag cctgctgaaa caggccggcg acgtggaaga gaaccctggc     4380

cccatggcgc ttcccgtgac cgcactcctg ttgccccttg ccctgctgtt gcacgccgca     4440

cgaccttccc aattccgggt gtcccctctg gatcgcacct ggaacctcgg ggaaacggtg     4500

gagctcaagt gtcaagtcct cctgtcgaac ccgaccagcg gatgcagctg gctgttccag     4560

ccgagaggag ctgccgcctc acccaccttc ctcctgtact tgagccagaa caagccgaag     4620

gccgctgagg gtctggacac ccagcgcttc tcgggcaaac ggctgggaga cacttttgtg     4680

ctgactctct ccgacttccg gcgggagaac gagggctact acttctgctc tgcgctctcc     4740

aattcaatca tgtacttctc acacttcgtg ccggtgttcc tgcctgccaa gcccaccact     4800

actccggcac ccagacctcc aactcccgct cccaccatcg cgtcccaacc cctttcgctg     4860

cgccctgaag cgtgtcggcc tgctgctgga ggagccgtgc atacccgcgg tctggacttc     4920

gcgtgcgaca tctacatttg ggcccctttg gctggcacct gtggagtgct gctcctgtcc     4980

cttgtgatca ccctgtactg caaccaccgg aataggcgga gagtctgcaa gtgtccgcgg     5040

cctgtcgtga agtcaggaga taagccgagc ctgtccgcac gctacgtgtg a              5091


<210>  261
<211>  2749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT.IL12

<400>  261
gtcgaccgtg gaggaaaaac tgtttcatac agaaggcgtg gaggaaaaac tgtttcatac       60

agaaggcgtg gaggaaaaac tgtttcatac agaaggcgtg gaggaaaaac tgtttcatac      120

agaaggcgtg gaggaaaaac tgtttcatac agaaggcgtg gaggaaaaac tgtttcatac      180

agaaggcgca ttttgacacc cccataatat ttttccagaa ttaacagtat aaattgcatc      240

tcttgttcaa gagttcccta tcactctctt taatcactac tcacagtaac ctcaactcct      300

gcccaagctt ggcattccgg tactgttggt aaagccacca tgtgtcacca gcagttggtc      360

atctcttggt tttccctggt ttttctggca tctcccctcg tggccatatg ggaactgaag      420

aaagatgttt atgtcgtaga attggattgg tatccggatg cccctggaga aatggtggtc      480

ctcacctgtg acacccctga agaagatggt atcacctgga ccttggacca gagcagtgag      540

gtcttaggct ctggcaaaac cctgaccatc caagtcaaag agtttggaga tgctggccag      600

tacacctgtc acaaaggagg cgaggttcta agccattcgc tcctgctgct tcacaaaaag      660

gaagatggaa tttggtccac tgatatttta aaggaccaga aagaacccaa aaataagacc      720

tttctaagat gcgaggccaa gaattattct ggacgtttca cctgctggtg gctgacgaca      780

atcagtactg atttgacatt cagtgtcaaa agcagcagag gctcttctga cccccaaggg      840

gtgacgtgcg gagctgctac actctctgca gagagagtca gaggggacaa caaggagtat      900

gagtactcag tggagtgcca ggaggacagt gcctgcccag ctgctgagga gagtctgccc      960

attgaggtca tggtggatgc cgttcacaag ctcaagtatg aaaactacac cagcagcttc     1020

ttcatcaggg acatcatcaa acctgaccca cccaagaact tgcagctgaa gccattaaag     1080

aattctcggc aggtggaggt cagctgggag taccctgaca cctggagtac tccacattcc     1140

tacttctccc tgacattctg cgttcaggtc cagggcaaga gcaagagaga aaagaaagat     1200

agagtcttca cggacaagac ctcagccacg gtcatctgcc gcaaacaagc cagcattagc     1260

gtgcgggccc aggaccgcta ctatagctca tcttggagcg agtgggcatc tgtgccctgc     1320

agtggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcat gtggccccct     1380

gggtcagcct cccagccacc gccctcacct gccgcggcca caggtctgca tccagcggct     1440

cgccctgtgt ccctgcagtg ccggctcagc atgtgtccag cgcgcagcct cctccttgtg     1500

gctaccctgg tcctcctgga ccacctcagt ttggccagaa acctccccgt ggccactcca     1560

gacccaggaa tgttcccatg ccttcaccac tcccaaaacc tgctgagggc cgtcagcaac     1620

atgctccaga aggccagaca aactctagaa ttttaccctt gcacttctga agagattgat     1680

catgaagata tcacaaaaga taaaaccagc acagtggagg cctgtttacc attggaatta     1740

accaagaatg agagttgcct aaattccaga gagacctctt tcataactaa tgggagttgc     1800

ctggcctcca gaaagacctc ttttatgatg gccctgtgcc ttagtagtat ttatgaagac     1860

ttgaagatgt accaggtgga gttcaagacc atgaatgcaa agcttctgat ggatcctaag     1920

aggcagatct ttctagatca aaacatgctg gcagttattg atgagctgat gcaggccctg     1980

aatttcaaca gtgagactgt gccacaaaaa tcctcccttg aagaaccgga tttttataaa     2040

actaaaatca agctctgcat acttcttcat gctttcagaa ttcgggcagt gactattgat     2100

agagtgatga gctatctgaa tgcttcctag tgaaccggtc cgcagtctga cgtacgcgta     2160

atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc     2220

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta     2280

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt     2340

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg     2400

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta     2460

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt     2520

tgggcactga caattccgtg gtgttgtcgg ggaagctgac gtcctttcca tggctgctcg     2580

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca     2640

atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc     2700

gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcc                 2749


<210>  262
<211>  5048
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD69pro.IL12

<400>  262
tttatgatag catagtagcc cagaccccgg cctaccttaa aattctatat ggtacatttg       60

ctattttcac accattatct ttgagagtag tctccaaaaa tgttgtatat ggataagtct      120

ggaattaatt taggtaaagt actcagacat ggttaagcgt tatatctcat ctttaatata      180

gctcttcttt tattctctta tgtattttac tttcagaaac agtcaggttt ttcagagtcc      240

aagcttgtgt gtacacaagc actatctttt accttcactg tctcaagtca aaaagaagaa      300

aatgccagct cacactttcc aagctcattt tttgtgtttc agatgttcca ttgaagagga      360

aagttagaaa gttcaaagac ttgaagagga cagaaggttg gaaagtgttt aaaactggaa      420

atcccccgtt tactcatggt taccttcatt gaccctttac ggtaaacaat tcaaaaacac      480

aaaggcacct gcaggttaaa aataaatttt accaatttgt gtaatttgca ttaatttgag      540

agaggatgat gtattctaaa ttgaagtttt gattcacaag aagattaaaa gccattcaga      600

aacctaattc acccactgaa aggaaaaaaa aaaaaagaga gatgagcagt ttgtctccgg      660

aaattgtctt aggtcggaag tctgtggtcc ctgttcacat gtacccaaaa gcatcctgct      720

gctgcagctg tctgataagc acagagtacc ccaccttctc tgcacacttt gcatctagct      780

catattacct catctttact tcctttctga cgtctcaccc tggattctac atataaggtc      840

acacaggaag gaaagctgca ttgagttttg gtgtcctgaa agacttttgc caaccttgtc      900

cccgcactaa tttctctaag cctcggctat actattttct cagctacacg atgaaatgtg      960

aatgataatt tctgccctaa aaatatcact taatttttta acatatcatt tatgaaagaa     1020

gacacataaa atgtctccct gaagagtgag tcggttaaag ggagagcgag acatgcaggg     1080

agatggaaaa agaatctttt agagaaaaag taaaagccct gtagtggtag gatgcttggc     1140

atttttaagg aggaggtttc tgtcagagag gatactgaat aataggaaaa atgataagag     1200

aggtaaccag gggccatatt atgtataaag cattctcaac tattaggtct ttggatttta     1260

cggtacattt gataggaagc ctttcaaagt gcagtggggg gaggagttaa acacttcacc     1320

aaaatcatat gaattaatta taaaacaatg gttctagctg ctatgtggaa aagggactaa     1380

gaaattgact gaaaaatagg atggaagcaa agggagcttt tagggccaac atgtacctct     1440

ttgtgtctta ggtagacaaa tgcatctaat ggtccaacta acttctctag atgataactt     1500

ccaacccacc tatgcataaa atttaacgtc tttattctaa ataagtgata ttaataataa     1560

aatttggggc accaagatta ttaatcagag tggtattttg atttccctcc ttaaatcacc     1620

atacatagct ttctgcattc atcttgcgtt gactgtcatt acttgtctga gtgagactga     1680

taccacagcg atgttttaaa taataatcat acctcaaaag actgaagtct cagaggtatc     1740

tgaagagaat aacctagagc acagggggag aattgaagga gctgttactg aggtgacata     1800

aaagcagtct aaatgacagt aaaatgtgac aagaaaatta gcaggaaaca aatgaaacag     1860

ataatttaag ataaacaatt ttagagcata gcaaggaagt tccagaccac aagctttctg     1920

tttcctgcat tcttacttct tactacgtga tacatctagt caccagggaa gaagcgaatg     1980

acacacttcc aaaaaccaat tcgtagcttt ctaaataaaa ccctttcaag ctggagagag     2040

atccatgagc atagagatct taaaattcat gttcagcaat aaatcctggg gccccagaca     2100

gtgtcaggtg catagggggt gttcagtaaa tatcagttaa atgtatgcat aaatcgataa     2160

acgggattcc tggaaaatac tacactctcc ttctccaaat tatcttcatc tcaaagacag     2220

gaacctctaa cttttaattc tttacttaga ttatgctgtc tcctaaactg tttatgtttt     2280

ctagaaattt aaggcaggat gtctcagagt ctgggaaaat cccactttcc tcctgctaca     2340

ccttacagtt gtgagaaagc acatttcaga caacagggaa aacccatact tcaccacaac     2400

aacacactat acattgtctg gtccactgga gcataaatta aagagaaaca atgtagtcaa     2460

gcaagtaggc ggcaagagga agggggcgga gacatcatca gggagtataa actctgagat     2520

gcctcagagc ctcacagact caacaagagc tccagcaaag actttcactg tagcttgact     2580

tgacctgaga ttaactaggg aatcttgaca gcggccgccc cgggtcgacg ctaccaccat     2640

gtgtcaccag cagttggtca tctcttggtt ttccctggtt tttctggcat ctcccctcgt     2700

ggccatatgg gaactgaaga aagatgttta tgtcgtagaa ttggattggt atccggatgc     2760

ccctggagaa atggtggtcc tcacctgtga cacccctgaa gaagatggta tcacctggac     2820

cttggaccag agcagtgagg tcttaggctc tggcaaaacc ctgaccatcc aagtcaaaga     2880

gtttggagat gctggccagt acacctgtca caaaggaggc gaggttctaa gccattcgct     2940

cctgctgctt cacaaaaagg aagatggaat ttggtccact gatattttaa aggaccagaa     3000

agaacccaaa aataagacct ttctaagatg cgaggccaag aattattctg gacgtttcac     3060

ctgctggtgg ctgacgacaa tcagtactga tttgacattc agtgtcaaaa gcagcagagg     3120

ctcttctgac ccccaagggg tgacgtgcgg agctgctaca ctctctgcag agagagtcag     3180

aggggacaac aaggagtatg agtactcagt ggagtgccag gaggacagtg cctgcccagc     3240

tgctgaggag agtctgccca ttgaggtcat ggtggatgcc gttcacaagc tcaagtatga     3300

aaactacacc agcagcttct tcatcaggga catcatcaaa cctgacccac ccaagaactt     3360

gcagctgaag ccattaaaga attctcggca ggtggaggtc agctgggagt accctgacac     3420

ctggagtact ccacattcct acttctccct gacattctgc gttcaggtcc agggcaagag     3480

caagagagaa aagaaagata gagtcttcac ggacaagacc tcagccacgg tcatctgccg     3540

caaacaagcc agcattagcg tgcgggccca ggaccgctac tatagctcat cttggagcga     3600

gtgggcatct gtgccctgca gtggcggcgg cggcagcggc ggcggcggca gcggcggcgg     3660

cggcagcatg tggccccctg ggtcagcctc ccagccaccg ccctcacctg ccgcggccac     3720

aggtctgcat ccagcggctc gccctgtgtc cctgcagtgc cggctcagca tgtgtccagc     3780

gcgcagcctc ctccttgtgg ctaccctggt cctcctggac cacctcagtt tggccagaaa     3840

cctccccgtg gccactccag acccaggaat gttcccatgc cttcaccact cccaaaacct     3900

gctgagggcc gtcagcaaca tgctccagaa ggccagacaa actctagaat tttacccttg     3960

cacttctgaa gagattgatc atgaagatat cacaaaagat aaaaccagca cagtggaggc     4020

ctgtttacca ttggaattaa ccaagaatga gagttgccta aattccagag agacctcttt     4080

cataactaat gggagttgcc tggcctccag aaagacctct tttatgatgg ccctgtgcct     4140

tagtagtatt tatgaagact tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa     4200

gcttctgatg gatcctaaga ggcagatctt tctagatcaa aacatgctgg cagttattga     4260

tgagctgatg caggccctga atttcaacag tgagactgtg ccacaaaaat cctcccttga     4320

agaaccggat ttttataaaa ctaaaatcaa gctctgcata cttcttcatg ctttcagaat     4380

tcgggcagtg actattgata gagtgatgag ctatctgaat gcttcctagt gaaccggtcc     4440

gcagtctgac gtacgcgtaa tcaacctctg gattacaaaa tttgtgaaag attgactggt     4500

attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat     4560

catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg     4620

tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt     4680

gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact     4740

ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc     4800

tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaagctgacg     4860

tcctttccat ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc     4920

tacgtccctt cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg     4980

cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc     5040

tccccgcc                                                              5048


<210>  263
<211>  1540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NFAT.IL18.var1

<400>  263
gtcgaccgtg gaggaaaaac tgtttcatac agaaggcgtg gaggaaaaac tgtttcatac       60

agaaggcgtg gaggaaaaac tgtttcatac agaaggcgtg gaggaaaaac tgtttcatac      120

agaaggcgtg gaggaaaaac tgtttcatac agaaggcgtg gaggaaaaac tgtttcatac      180

agaaggcgca ttttgacacc cccataatat ttttccagaa ttaacagtat aaattgcatc      240

tcttgttcaa gagttcccta tcactctctt taatcactac tcacagtaac ctcaactcct      300

gcccaagctt ggcattccgg tactgttggt aaagccacca tggctgctga accagtagaa      360

gacaattgca tcaactttgt ggcaatgaaa tttattgaca atacgcttta ctttatagct      420

gaagatgatg aaaacctgga atcagattac tttggcaagc ttgaatctaa attatcagtc      480

ataagaaatt tgaatgacca agttctcttc attgaccaag gaaatcggcc tctatttgaa      540

gatatgactg attctgactg tagagataat gcaccccgga ccatatttat tataagtatg      600

tataaagata gccagcctag aggtatggct gtaactatct ctgtgaagtg tgagaaaatt      660

tcaactctct cctgtgagaa caaaattatt tcctttaagg aaatgaatcc tcctgataac      720

atcaaggata caaaaagtga catcatattc tttcagagaa gtgtcccagg acatgataat      780

aagatgcaat ttgaatcttc atcatacgaa ggatactttc tagcttgtga aaaagagaga      840

gaccttttta aactcatttt gaaaaaagag gatgaattgg gggatagatc tataatgttc      900

actgttcaaa acgaagacta gtgaaccggt ccgcagtctg acgtacgcgt aatcaacctc      960

tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc     1020

tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca     1080

ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg     1140

tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca     1200

ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg     1260

cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg     1320

acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc gcctgtgttg     1380

ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg     1440

accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc     1500

ctcagacgag tcggatctcc ctttgggccg cctccccgcc                           1540


<210>  264
<211>  3839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD69pro.IL18.var1

<400>  264
tttatgatag catagtagcc cagaccccgg cctaccttaa aattctatat ggtacatttg       60

ctattttcac accattatct ttgagagtag tctccaaaaa tgttgtatat ggataagtct      120

ggaattaatt taggtaaagt actcagacat ggttaagcgt tatatctcat ctttaatata      180

gctcttcttt tattctctta tgtattttac tttcagaaac agtcaggttt ttcagagtcc      240

aagcttgtgt gtacacaagc actatctttt accttcactg tctcaagtca aaaagaagaa      300

aatgccagct cacactttcc aagctcattt tttgtgtttc agatgttcca ttgaagagga      360

aagttagaaa gttcaaagac ttgaagagga cagaaggttg gaaagtgttt aaaactggaa      420

atcccccgtt tactcatggt taccttcatt gaccctttac ggtaaacaat tcaaaaacac      480

aaaggcacct gcaggttaaa aataaatttt accaatttgt gtaatttgca ttaatttgag      540

agaggatgat gtattctaaa ttgaagtttt gattcacaag aagattaaaa gccattcaga      600

aacctaattc acccactgaa aggaaaaaaa aaaaaagaga gatgagcagt ttgtctccgg      660

aaattgtctt aggtcggaag tctgtggtcc ctgttcacat gtacccaaaa gcatcctgct      720

gctgcagctg tctgataagc acagagtacc ccaccttctc tgcacacttt gcatctagct      780

catattacct catctttact tcctttctga cgtctcaccc tggattctac atataaggtc      840

acacaggaag gaaagctgca ttgagttttg gtgtcctgaa agacttttgc caaccttgtc      900

cccgcactaa tttctctaag cctcggctat actattttct cagctacacg atgaaatgtg      960

aatgataatt tctgccctaa aaatatcact taatttttta acatatcatt tatgaaagaa     1020

gacacataaa atgtctccct gaagagtgag tcggttaaag ggagagcgag acatgcaggg     1080

agatggaaaa agaatctttt agagaaaaag taaaagccct gtagtggtag gatgcttggc     1140

atttttaagg aggaggtttc tgtcagagag gatactgaat aataggaaaa atgataagag     1200

aggtaaccag gggccatatt atgtataaag cattctcaac tattaggtct ttggatttta     1260

cggtacattt gataggaagc ctttcaaagt gcagtggggg gaggagttaa acacttcacc     1320

aaaatcatat gaattaatta taaaacaatg gttctagctg ctatgtggaa aagggactaa     1380

gaaattgact gaaaaatagg atggaagcaa agggagcttt tagggccaac atgtacctct     1440

ttgtgtctta ggtagacaaa tgcatctaat ggtccaacta acttctctag atgataactt     1500

ccaacccacc tatgcataaa atttaacgtc tttattctaa ataagtgata ttaataataa     1560

aatttggggc accaagatta ttaatcagag tggtattttg atttccctcc ttaaatcacc     1620

atacatagct ttctgcattc atcttgcgtt gactgtcatt acttgtctga gtgagactga     1680

taccacagcg atgttttaaa taataatcat acctcaaaag actgaagtct cagaggtatc     1740

tgaagagaat aacctagagc acagggggag aattgaagga gctgttactg aggtgacata     1800

aaagcagtct aaatgacagt aaaatgtgac aagaaaatta gcaggaaaca aatgaaacag     1860

ataatttaag ataaacaatt ttagagcata gcaaggaagt tccagaccac aagctttctg     1920

tttcctgcat tcttacttct tactacgtga tacatctagt caccagggaa gaagcgaatg     1980

acacacttcc aaaaaccaat tcgtagcttt ctaaataaaa ccctttcaag ctggagagag     2040

atccatgagc atagagatct taaaattcat gttcagcaat aaatcctggg gccccagaca     2100

gtgtcaggtg catagggggt gttcagtaaa tatcagttaa atgtatgcat aaatcgataa     2160

acgggattcc tggaaaatac tacactctcc ttctccaaat tatcttcatc tcaaagacag     2220

gaacctctaa cttttaattc tttacttaga ttatgctgtc tcctaaactg tttatgtttt     2280

ctagaaattt aaggcaggat gtctcagagt ctgggaaaat cccactttcc tcctgctaca     2340

ccttacagtt gtgagaaagc acatttcaga caacagggaa aacccatact tcaccacaac     2400

aacacactat acattgtctg gtccactgga gcataaatta aagagaaaca atgtagtcaa     2460

gcaagtaggc ggcaagagga agggggcgga gacatcatca gggagtataa actctgagat     2520

gcctcagagc ctcacagact caacaagagc tccagcaaag actttcactg tagcttgact     2580

tgacctgaga ttaactaggg aatcttgaca gcggccgccc cgggtcgacg ctaccaccat     2640

ggctgctgaa ccagtagaag acaattgcat caactttgtg gcaatgaaat ttattgacaa     2700

tacgctttac tttatagctg aagatgatga aaacctggaa tcagattact ttggcaagct     2760

tgaatctaaa ttatcagtca taagaaattt gaatgaccaa gttctcttca ttgaccaagg     2820

aaatcggcct ctatttgaag atatgactga ttctgactgt agagataatg caccccggac     2880

catatttatt ataagtatgt ataaagatag ccagcctaga ggtatggctg taactatctc     2940

tgtgaagtgt gagaaaattt caactctctc ctgtgagaac aaaattattt cctttaagga     3000

aatgaatcct cctgataaca tcaaggatac aaaaagtgac atcatattct ttcagagaag     3060

tgtcccagga catgataata agatgcaatt tgaatcttca tcatacgaag gatactttct     3120

agcttgtgaa aaagagagag acctttttaa actcattttg aaaaaagagg atgaattggg     3180

ggatagatct ataatgttca ctgttcaaaa cgaagactag tgaaccggtc cgcagtctga     3240

cgtacgcgta atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac     3300

tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt     3360

gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat     3420

gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca     3480

acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc     3540

cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg     3600

gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaagctgac gtcctttcca     3660

tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct     3720

tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt     3780

ccgcgtcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcc      3839


<210>  265
<211>  607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPREmut1

<400>  265
cagtctgacg tacgcgtaat caacctctgg attacaaaat ttgtgaaaga ttgactggta       60

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc      120

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt      180

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg      240

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt      300

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct      360

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt      420

cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct      480

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc      540

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct      600

ccccgcc                                                                607


<210>  266
<211>  581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPREmut2

<400>  266
gagcatctta ccgccattta tacccatatt tgttctgttt ttcttgattt gggtatacat       60

ttaaatgtta ataaaacaaa atggtggggc aatcatttac attttttggg atatgtaatt      120

actagttcag gtgtattgcc acaagacaaa cttgttaaga aactttcccg ttatttacgc      180

tctgttcctg ttaatcaacc tctggattac aaaatttgtg aaagattgac tgatattctt      240

aactttgttg ctccttttac gctgtgtgga tttgctgctt tattgcctct gtatcttgct      300

attgcttccc gtacggcttt cgttttctcc tccttgtata aatcctggtt gctgtctctt      360

tttgaggagt tgtggcccgt tgtccgtcaa cgtggcgtgg tgtgctctgt gtttgctgac      420

gcaaccccca ctggctgggg cattgccacc acctgtcaac tcctttctgg gactttcgct      480

ttccccctcc cgatcgccac ggcagaactc atcgccgcct gccttgcccg ctgctggaca      540

ggggctaggt tgctgggcac tgataattcc gtggtgttgt c                          581


