                         SEQUENCE LISTING

<110>  H. Lee Moffitt Cancer Center and Research Institute, Inc.
 
<120>  THERAPEUTIC T-CELLS WITH MODIFIED EXPRESSION OF T-BET, EOMES, AND
        c-MYB TRANSCRIPTION FACTORS

<130>  320803-2350

<150>  US 62/854,228
<151>  2019-05-29

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ile Val Glu Pro Gly Cys Gly Asp Met Leu Thr Gly Thr Glu 
1               5                   10                  15      


Pro Met Pro Gly Ser Asp Glu Gly Arg Ala Pro Gly Ala Asp Pro Gln 
            20                  25                  30          


His Arg Tyr Phe Tyr Pro Glu Pro Gly Ala Gln Asp Ala Asp Glu Arg 
        35                  40                  45              


Arg Gly Gly Gly Ser Leu Gly Ser Pro Tyr Pro Gly Gly Ala Leu Val 
    50                  55                  60                  


Pro Ala Pro Pro Ser Arg Phe Leu Gly Ala Tyr Ala Tyr Pro Pro Arg 
65                  70                  75                  80  


Pro Gln Ala Ala Gly Phe Pro Gly Ala Gly Glu Ser Phe Pro Pro Pro 
                85                  90                  95      


Ala Asp Ala Glu Gly Tyr Gln Pro Gly Glu Gly Tyr Ala Ala Pro Asp 
            100                 105                 110         


Pro Arg Ala Gly Leu Tyr Pro Gly Pro Arg Glu Asp Tyr Ala Leu Pro 
        115                 120                 125             


Ala Gly Leu Glu Val Ser Gly Lys Leu Arg Val Ala Leu Asn Asn His 
    130                 135                 140                 


Leu Leu Trp Ser Lys Phe Asn Gln His Gln Thr Glu Met Ile Ile Thr 
145                 150                 155                 160 


Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Thr Val Ala Gly 
                165                 170                 175     


Leu Glu Pro Thr Ser His Tyr Arg Met Phe Val Asp Val Val Leu Val 
            180                 185                 190         


Asp Gln His His Trp Arg Tyr Gln Ser Gly Lys Trp Val Gln Cys Gly 
        195                 200                 205             


Lys Ala Glu Gly Ser Met Pro Gly Asn Arg Leu Tyr Val His Pro Asp 
    210                 215                 220                 


Ser Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Val Ser Phe Gly 
225                 230                 235                 240 


Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn Val Thr Gln 
                245                 250                 255     


Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu His Ile 
            260                 265                 270         


Val Glu Val Asn Asp Gly Glu Pro Glu Ala Ala Cys Asn Ala Ser Asn 
        275                 280                 285             


Thr His Ile Phe Thr Phe Gln Glu Thr Gln Phe Ile Ala Val Thr Ala 
    290                 295                 300                 


Tyr Gln Asn Ala Glu Ile Thr Gln Leu Lys Ile Asp Asn Asn Pro Phe 
305                 310                 315                 320 


Ala Lys Gly Phe Arg Glu Asn Phe Glu Ser Met Tyr Thr Ser Val Asp 
                325                 330                 335     


Thr Ser Ile Pro Ser Pro Pro Gly Pro Asn Cys Gln Phe Leu Gly Gly 
            340                 345                 350         


Asp His Tyr Ser Pro Leu Leu Pro Asn Gln Tyr Pro Val Pro Ser Arg 
        355                 360                 365             


Phe Tyr Pro Asp Leu Pro Gly Gln Ala Lys Asp Val Val Pro Gln Ala 
    370                 375                 380                 


Tyr Trp Leu Gly Ala Pro Arg Asp His Ser Tyr Glu Ala Glu Phe Arg 
385                 390                 395                 400 


Ala Val Ser Met Lys Pro Ala Phe Leu Pro Ser Ala Pro Gly Pro Thr 
                405                 410                 415     


Met Ser Tyr Tyr Arg Gly Gln Glu Val Leu Ala Pro Gly Ala Gly Trp 
            420                 425                 430         


Pro Val Ala Pro Gln Tyr Pro Pro Lys Met Gly Pro Ala Ser Trp Phe 
        435                 440                 445             


Arg Pro Met Arg Thr Leu Pro Met Glu Pro Gly Pro Gly Gly Ser Glu 
    450                 455                 460                 


Gly Arg Gly Pro Glu Asp Gln Gly Pro Pro Leu Val Trp Thr Glu Ile 
465                 470                 475                 480 


Ala Pro Ile Arg Pro Glu Ser Ser Asp Ser Gly Leu Gly Glu Gly Asp 
                485                 490                 495     


Ser Lys Arg Arg Arg Val Ser Pro Tyr Pro Ser Ser Gly Asp Ser Ser 
            500                 505                 510         


Ser Pro Ala Gly Ala Pro Ser Pro Phe Asp Lys Glu Ala Glu Gly Gln 
        515                 520                 525             


Phe Tyr Asn Tyr Phe Pro Asn 
    530                 535 


<210>  2
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Leu Gly Glu Gln Leu Leu Val Ser Ser Val Asn Leu Pro Gly 
1               5                   10                  15      


Ala His Phe Tyr Pro Leu Glu Ser Ala Arg Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Ala Gly His Leu Pro Ser Ala Ala Pro Ser Pro Gln Lys Leu Asp Leu 
        35                  40                  45              


Asp Lys Ala Ser Lys Lys Phe Ser Gly Ser Leu Ser Cys Glu Ala Val 
    50                  55                  60                  


Ser Gly Glu Pro Ala Ala Ala Ser Ala Gly Ala Pro Ala Ala Met Leu 
65                  70                  75                  80  


Ser Asp Thr Asp Ala Gly Asp Ala Phe Ala Ser Ala Ala Ala Val Ala 
                85                  90                  95      


Lys Pro Gly Pro Pro Asp Gly Arg Lys Gly Ser Pro Cys Gly Glu Glu 
            100                 105                 110         


Glu Leu Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Thr Ala Arg Tyr Ser Met Asp Ser Leu Ser Ser Glu Arg Tyr 
    130                 135                 140                 


Tyr Leu Gln Ser Pro Gly Pro Gln Gly Ser Glu Leu Ala Ala Pro Cys 
145                 150                 155                 160 


Ser Leu Phe Pro Tyr Gln Ala Ala Ala Gly Ala Pro His Gly Pro Val 
                165                 170                 175     


Tyr Pro Ala Pro Asn Gly Ala Arg Tyr Pro Tyr Gly Ser Met Leu Pro 
            180                 185                 190         


Pro Gly Gly Phe Pro Ala Ala Val Cys Pro Pro Gly Arg Ala Gln Phe 
        195                 200                 205             


Gly Pro Gly Ala Gly Ala Gly Ser Gly Ala Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Gly Gly Gly Pro Gly Thr Tyr Gln Tyr Ser Gln Gly Ala Pro Leu Tyr 
225                 230                 235                 240 


Gly Pro Tyr Pro Gly Ala Ala Ala Ala Gly Ser Cys Gly Gly Leu Gly 
                245                 250                 255     


Gly Leu Gly Val Pro Gly Ser Gly Phe Arg Ala His Val Tyr Leu Cys 
            260                 265                 270         


Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met Ile 
        275                 280                 285             


Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn Ile 
    290                 295                 300                 


Asn Gly Leu Asn Pro Thr Ala His Tyr Asn Val Phe Val Glu Val Val 
305                 310                 315                 320 


Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val Thr 
                325                 330                 335     


Cys Gly Lys Ala Asp Asn Asn Met Gln Gly Asn Lys Met Tyr Val His 
            340                 345                 350         


Pro Glu Ser Pro Asn Thr Gly Ser His Trp Met Arg Gln Glu Ile Ser 
        355                 360                 365             


Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Asn Asn Asn Asn 
    370                 375                 380                 


Thr Gln Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu 
385                 390                 395                 400 


His Ile Val Glu Val Thr Glu Asp Gly Val Glu Asp Leu Asn Glu Pro 
                405                 410                 415     


Ser Lys Thr Gln Thr Phe Thr Phe Ser Glu Thr Gln Phe Ile Ala Val 
            420                 425                 430         


Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His Asn 
        435                 440                 445             


Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Ser Ser His Gln Ile 
    450                 455                 460                 


Val Pro Gly Gly Arg Tyr Gly Val Gln Ser Phe Phe Pro Glu Pro Phe 
465                 470                 475                 480 


Val Asn Thr Leu Pro Gln Ala Arg Tyr Tyr Asn Gly Glu Arg Thr Val 
                485                 490                 495     


Pro Gln Thr Asn Gly Leu Leu Ser Pro Gln Gln Ser Glu Glu Val Ala 
            500                 505                 510         


Asn Pro Pro Gln Arg Trp Leu Val Thr Pro Val Gln Gln Pro Gly Thr 
        515                 520                 525             


Asn Lys Leu Asp Ile Ser Ser Tyr Glu Ser Glu Tyr Thr Ser Ser Thr 
    530                 535                 540                 


Leu Leu Pro Tyr Gly Ile Lys Ser Leu Pro Leu Gln Thr Ser His Ala 
545                 550                 555                 560 


Leu Gly Tyr Tyr Pro Asp Pro Thr Phe Pro Ala Met Ala Gly Trp Gly 
                565                 570                 575     


Gly Arg Gly Ser Tyr Gln Arg Lys Met Ala Ala Gly Leu Pro Trp Thr 
            580                 585                 590         


Ser Arg Thr Ser Pro Thr Val Phe Ser Glu Asp Gln Leu Ser Lys Glu 
        595                 600                 605             


Lys Val Lys Glu Glu Ile Gly Ser Ser Trp Ile Glu Thr Pro Pro Ser 
    610                 615                 620                 


Ile Lys Ser Leu Asp Ser Asn Asp Ser Gly Val Tyr Thr Ser Ala Cys 
625                 630                 635                 640 


Lys Arg Arg Arg Leu Ser Pro Ser Asn Ser Ser Asn Glu Asn Ser Pro 
                645                 650                 655     


Ser Ile Lys Cys Glu Asp Ile Asn Ala Glu Glu Tyr Ser Lys Asp Thr 
            660                 665                 670         


Ser Lys Gly Met Gly Gly Tyr Tyr Ala Phe Tyr Thr Thr Pro 
        675                 680                 685     


<210>  3
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Arg Arg Pro Arg His Ser Ile Tyr Ser Ser Asp Glu Asp Asp 
1               5                   10                  15      


Glu Asp Phe Glu Met Cys Asp His Asp Tyr Asp Gly Leu Leu Pro Lys 
            20                  25                  30          


Ser Gly Lys Arg His Leu Gly Lys Thr Arg Trp Thr Arg Glu Glu Asp 
        35                  40                  45              


Glu Lys Leu Lys Lys Leu Val Glu Gln Asn Gly Thr Asp Asp Trp Lys 
    50                  55                  60                  


Val Ile Ala Asn Tyr Leu Pro Asn Arg Thr Asp Val Gln Cys Gln His 
65                  70                  75                  80  


Arg Trp Gln Lys Val Leu Asn Pro Glu Leu Ile Lys Gly Pro Trp Thr 
                85                  90                  95      


Lys Glu Glu Asp Gln Arg Val Ile Glu Leu Val Gln Lys Tyr Gly Pro 
            100                 105                 110         


Lys Arg Trp Ser Val Ile Ala Lys His Leu Lys Gly Arg Ile Gly Lys 
        115                 120                 125             


Gln Cys Arg Glu Arg Trp His Asn His Leu Asn Pro Glu Val Lys Lys 
    130                 135                 140                 


Thr Ser Trp Thr Glu Glu Glu Asp Arg Ile Ile Tyr Gln Ala His Lys 
145                 150                 155                 160 


Arg Leu Gly Asn Arg Trp Ala Glu Ile Ala Lys Leu Leu Pro Gly Arg 
                165                 170                 175     


Thr Asp Asn Ala Ile Lys Asn His Trp Asn Ser Thr Met Arg Arg Lys 
            180                 185                 190         


Val Glu Gln Glu Gly Tyr Leu Gln Met Ala Leu Glu Asp Arg Cys Ser 
        195                 200                 205             


Pro Gln Ser Ala Pro Ser Pro Ile Thr Leu Gln Met Gln His Leu His 
    210                 215                 220                 


His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Met Gln His Leu 
225                 230                 235                 240 


His Gln Leu Gln Gln Leu Gln Gln Leu His Gln Gln Gln Leu Ala Ala 
                245                 250                 255     


Gly Val Phe His His Pro Ala Met Ala Phe Asp Ala Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Ala Ala Ala Ala His Ala His Ala Ala Ala Leu 
        275                 280                 285             


Gln Gln Arg Leu Ser Gly Ser Gly Ser Pro Ala Ser Cys Ser Thr Pro 
    290                 295                 300                 


Ala Ser Ser Thr Pro Leu Thr Ile Lys Glu Glu Glu Ser Asp Ser Val 
305                 310                 315                 320 


Ile Gly Asp Met Ser Phe His Asn Gln Thr His Thr Thr Asn Glu Glu 
                325                 330                 335     


Glu Glu Ala Glu Glu Asp Asp Asp Ile Asp Val Asp Val Asp Asp Thr 
            340                 345                 350         


Ser Ala Gly Gly Arg Leu Pro Pro Pro Ala His Gln Gln Gln Ser Thr 
        355                 360                 365             


Ala Lys Pro Ser Leu Ala Phe Ser Ile Ser Asn Ile Leu Ser Asp Arg 
    370                 375                 380                 


Phe Gly Asp Val Gln Lys Pro Gly Lys Ser Ile Glu Asn Gln Ala Ser 
385                 390                 395                 400 


Ile Phe Arg Pro Phe Glu Ala Asn Arg Ser Gln Thr Ala Thr Pro Ser 
                405                 410                 415     


Ala Phe Thr Arg Val Asp Leu Leu Glu Phe Ser Arg Gln Gln Gln Ala 
            420                 425                 430         


Ala Ala Ala Ala Ala Thr Ala Ala Met Met Leu Glu Arg Ala Asn Phe 
        435                 440                 445             


Leu Asn Cys Phe Asn Pro Ala Ala Tyr Pro Arg Ile His Glu Glu Ile 
    450                 455                 460                 


Val Gln Ser Arg Leu Arg Arg Ser Ala Ala Asn Ala Val Ile Pro Pro 
465                 470                 475                 480 


Pro Met Ser Ser Lys Met Ser Asp Ala Asn Pro Glu Lys Ser Ala Leu 
                485                 490                 495     


Gly Ser 
        


<210>  4
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Ile Val Glu Pro Gly Cys Gly Asp Met Leu Thr Gly Thr Glu 
1               5                   10                  15      


Pro Met Pro Gly Ser Asp Glu Gly Arg Ala Pro Gly Ala Asp Pro Gln 
            20                  25                  30          


His Arg Tyr Phe Tyr Pro Glu Pro Gly Ala Gln Asp Ala Asp Glu Arg 
        35                  40                  45              


Arg Gly Gly Gly Ser Leu Gly Ser Pro Tyr Pro Gly Gly Ala Leu Val 
    50                  55                  60                  


Pro Ala Pro Pro Ser Arg Phe Leu Gly Ala Tyr Ala Tyr Pro Pro Arg 
65                  70                  75                  80  


Pro Gln Ala Ala Gly Phe Pro Gly Ala Gly Glu Ser Phe Pro Pro Pro 
                85                  90                  95      


Ala Asp Ala Glu Gly Tyr Gln Pro Gly Glu Gly Tyr Ala Ala Pro Asp 
            100                 105                 110         


Pro Arg Ala Gly Leu Tyr Pro Gly Pro Arg Glu Asp Tyr Ala Leu Pro 
        115                 120                 125             


Ala Gly Leu Glu Val Ser Gly Lys Leu Arg Val Ala Leu Asn Asn His 
    130                 135                 140                 


Leu Leu Trp Ser Lys Phe Asn Gln His Gln Thr Glu Met Ile Ile Thr 
145                 150                 155                 160 


Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Thr Val Ala Gly 
                165                 170                 175     


Leu Glu Pro Thr Ser His Tyr Arg Met Phe Val Asp Val Val Leu Val 
            180                 185                 190         


Asp Gln His His Trp Arg Tyr Gln Ser Gly Lys Trp Val Gln Cys Gly 
        195                 200                 205             


Lys Ala Glu Gly Ser Met Pro Gly Asn Arg Leu Tyr Val His Pro Asp 
    210                 215                 220                 


Ser Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Val Ser Phe Gly 
225                 230                 235                 240 


Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn Val Thr Gln 
                245                 250                 255     


Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu His Ile 
            260                 265                 270         


Val Glu Val Asn Asp Gly Glu Pro Glu Ala Ala Cys Asn Ala Ser Asn 
        275                 280                 285             


Thr His Ile Phe Thr Phe Gln Glu Thr Gln Phe Ile Ala Val Thr Ala 
    290                 295                 300                 


Tyr Gln Asn Ala Glu Ile Thr Gln Leu Lys Ile Asp Asn Asn Pro Phe 
305                 310                 315                 320 


Ala Lys Gly Phe Arg Glu Asn Phe Glu Ser Met Tyr Thr Ser Val Asp 
                325                 330                 335     


Thr Ser Ile Pro Ser Pro Pro Gly Pro Asn Cys Gln Phe Leu Gly Gly 
            340                 345                 350         


Asp His Tyr Ser Pro Leu Leu Pro Asn Gln Tyr Pro Val Pro Ser Arg 
        355                 360                 365             


Phe Tyr Pro Asp Met Ala Leu Glu Asp Arg Cys Ser Pro Gln Ser Ala 
    370                 375                 380                 


Pro Ser Pro Ile Thr Leu Gln Met Gln His Leu His His Gln Gln Gln 
385                 390                 395                 400 


Gln Gln Gln Gln Gln Gln Gln Gln Met Gln His Leu His Gln Leu Gln 
                405                 410                 415     


Gln Leu Gln Gln Leu His Gln Gln Gln Leu Ala Ala Gly Val Phe His 
            420                 425                 430         


His Pro Ala Met Ala Phe Asp Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        435                 440                 445             


Ala Ala Ala Ala Ala His Ala His Ala Ala Ala Leu Gln Gln Arg Leu 
    450                 455                 460                 


Ser Gly Ser Gly Ser Pro Ala Ser Cys Ser Thr Pro Ala Ser Ser Thr 
465                 470                 475                 480 


Pro Leu Thr Ile Lys Glu Glu Glu Ser Asp Ser Val Ile Gly Asp Met 
                485                 490                 495     


Ser Phe His Asn Gln Thr His Thr Thr Asn Glu Glu Glu Glu Ala Glu 
            500                 505                 510         


Glu Asp Asp Asp Ile Asp Val Asp Val Asp Asp Thr Ser Ala Gly Gly 
        515                 520                 525             


Arg Leu Pro Pro Pro Ala His Gln Gln Gln Ser Thr Ala Lys Pro Ser 
    530                 535                 540                 


Leu Ala Phe Ser Ile Ser Asn Ile Leu Ser Asp Arg Phe Gly Asp Val 
545                 550                 555                 560 


Gln Lys Pro Gly Lys Ser Ile Glu Asn Gln Ala Ser Ile Phe Arg Pro 
                565                 570                 575     


Phe Glu Ala Asn Arg Ser Gln Thr Ala Thr Pro Ser Ala Phe Thr Arg 
            580                 585                 590         


Val Asp Leu Leu Glu Phe Ser Arg Gln Gln Gln Ala Ala Ala Ala Ala 
        595                 600                 605             


Ala Thr Ala Ala Met Met Leu Glu Arg Ala Asn Phe Leu Asn Cys Phe 
    610                 615                 620                 


Asn Pro Ala Ala Tyr Pro Arg Ile His Glu Glu Ile Val Gln Ser Arg 
625                 630                 635                 640 


Leu Arg Arg Ser Ala Ala Asn Ala Val Ile Pro Pro Pro Met Ser Ser 
                645                 650                 655     


Lys Met Ser Asp Ala Asn Pro Glu Lys Ser Ala Leu Gly Ser 
            660                 665                 670 


<210>  5
<211>  799
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gln Leu Gly Glu Gln Leu Leu Val Ser Ser Val Asn Leu Pro Gly 
1               5                   10                  15      


Ala His Phe Tyr Pro Leu Glu Ser Ala Arg Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Ala Gly His Leu Pro Ser Ala Ala Pro Ser Pro Gln Lys Leu Asp Leu 
        35                  40                  45              


Asp Lys Ala Ser Lys Lys Phe Ser Gly Ser Leu Ser Cys Glu Ala Val 
    50                  55                  60                  


Ser Gly Glu Pro Ala Ala Ala Ser Ala Gly Ala Pro Ala Ala Met Leu 
65                  70                  75                  80  


Ser Asp Thr Asp Ala Gly Asp Ala Phe Ala Ser Ala Ala Ala Val Ala 
                85                  90                  95      


Lys Pro Gly Pro Pro Asp Gly Arg Lys Gly Ser Pro Cys Gly Glu Glu 
            100                 105                 110         


Glu Leu Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Thr Ala Arg Tyr Ser Met Asp Ser Leu Ser Ser Glu Arg Tyr 
    130                 135                 140                 


Tyr Leu Gln Ser Pro Gly Pro Gln Gly Ser Glu Leu Ala Ala Pro Cys 
145                 150                 155                 160 


Ser Leu Phe Pro Tyr Gln Ala Ala Ala Gly Ala Pro His Gly Pro Val 
                165                 170                 175     


Tyr Pro Ala Pro Asn Gly Ala Arg Tyr Pro Tyr Gly Ser Met Leu Pro 
            180                 185                 190         


Pro Gly Gly Phe Pro Ala Ala Val Cys Pro Pro Gly Arg Ala Gln Phe 
        195                 200                 205             


Gly Pro Gly Ala Gly Ala Gly Ser Gly Ala Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Gly Gly Gly Pro Gly Thr Tyr Gln Tyr Ser Gln Gly Ala Pro Leu Tyr 
225                 230                 235                 240 


Gly Pro Tyr Pro Gly Ala Ala Ala Ala Gly Ser Cys Gly Gly Leu Gly 
                245                 250                 255     


Gly Leu Gly Val Pro Gly Ser Gly Phe Arg Ala His Val Tyr Leu Cys 
            260                 265                 270         


Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met Ile 
        275                 280                 285             


Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn Ile 
    290                 295                 300                 


Asn Gly Leu Asn Pro Thr Ala His Tyr Asn Val Phe Val Glu Val Val 
305                 310                 315                 320 


Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val Thr 
                325                 330                 335     


Cys Gly Lys Ala Asp Asn Asn Met Gln Gly Asn Lys Met Tyr Val His 
            340                 345                 350         


Pro Glu Ser Pro Asn Thr Gly Ser His Trp Met Arg Gln Glu Ile Ser 
        355                 360                 365             


Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Asn Asn Asn Asn 
    370                 375                 380                 


Thr Gln Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu 
385                 390                 395                 400 


His Ile Val Glu Val Thr Glu Asp Gly Val Glu Asp Leu Asn Glu Pro 
                405                 410                 415     


Ser Lys Thr Gln Thr Phe Thr Phe Ser Glu Thr Gln Phe Ile Ala Val 
            420                 425                 430         


Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His Asn 
        435                 440                 445             


Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Ser Ser His Gln Ile 
    450                 455                 460                 


Val Pro Gly Gly Arg Tyr Gly Val Gln Ser Phe Phe Pro Glu Pro Phe 
465                 470                 475                 480 


Val Asn Thr Leu Pro Gln Ala Arg Tyr Tyr Asn Gly Glu Arg Thr Val 
                485                 490                 495     


Pro Gln Thr Asn Gly Met Ala Leu Glu Asp Arg Cys Ser Pro Gln Ser 
            500                 505                 510         


Ala Pro Ser Pro Ile Thr Leu Gln Met Gln His Leu His His Gln Gln 
        515                 520                 525             


Gln Gln Gln Gln Gln Gln Gln Gln Gln Met Gln His Leu His Gln Leu 
    530                 535                 540                 


Gln Gln Leu Gln Gln Leu His Gln Gln Gln Leu Ala Ala Gly Val Phe 
545                 550                 555                 560 


His His Pro Ala Met Ala Phe Asp Ala Ala Ala Ala Ala Ala Ala Ala 
                565                 570                 575     


Ala Ala Ala Ala Ala Ala His Ala His Ala Ala Ala Leu Gln Gln Arg 
            580                 585                 590         


Leu Ser Gly Ser Gly Ser Pro Ala Ser Cys Ser Thr Pro Ala Ser Ser 
        595                 600                 605             


Thr Pro Leu Thr Ile Lys Glu Glu Glu Ser Asp Ser Val Ile Gly Asp 
    610                 615                 620                 


Met Ser Phe His Asn Gln Thr His Thr Thr Asn Glu Glu Glu Glu Ala 
625                 630                 635                 640 


Glu Glu Asp Asp Asp Ile Asp Val Asp Val Asp Asp Thr Ser Ala Gly 
                645                 650                 655     


Gly Arg Leu Pro Pro Pro Ala His Gln Gln Gln Ser Thr Ala Lys Pro 
            660                 665                 670         


Ser Leu Ala Phe Ser Ile Ser Asn Ile Leu Ser Asp Arg Phe Gly Asp 
        675                 680                 685             


Val Gln Lys Pro Gly Lys Ser Ile Glu Asn Gln Ala Ser Ile Phe Arg 
    690                 695                 700                 


Pro Phe Glu Ala Asn Arg Ser Gln Thr Ala Thr Pro Ser Ala Phe Thr 
705                 710                 715                 720 


Arg Val Asp Leu Leu Glu Phe Ser Arg Gln Gln Gln Ala Ala Ala Ala 
                725                 730                 735     


Ala Ala Thr Ala Ala Met Met Leu Glu Arg Ala Asn Phe Leu Asn Cys 
            740                 745                 750         


Phe Asn Pro Ala Ala Tyr Pro Arg Ile His Glu Glu Ile Val Gln Ser 
        755                 760                 765             


Arg Leu Arg Arg Ser Ala Ala Asn Ala Val Ile Pro Pro Pro Met Ser 
    770                 775                 780                 


Ser Lys Met Ser Asp Ala Asn Pro Glu Lys Ser Ala Leu Gly Ser 
785                 790                 795                 


<210>  6
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Arg Arg Pro Arg His Ser Ile Tyr Ser Ser Asp Glu Asp Asp 
1               5                   10                  15      


Glu Asp Phe Glu Met Cys Asp His Asp Tyr Asp Gly Leu Leu Pro Lys 
            20                  25                  30          


Ser Gly Lys Arg His Leu Gly Lys Thr Arg Trp Thr Arg Glu Glu Asp 
        35                  40                  45              


Glu Lys Leu Lys Lys Leu Val Glu Gln Asn Gly Thr Asp Asp Trp Lys 
    50                  55                  60                  


Val Ile Ala Asn Tyr Leu Pro Asn Arg Thr Asp Val Gln Cys Gln His 
65                  70                  75                  80  


Arg Trp Gln Lys Val Leu Asn Pro Glu Leu Ile Lys Gly Pro Trp Thr 
                85                  90                  95      


Lys Glu Glu Asp Gln Arg Val Ile Glu Leu Val Gln Lys Tyr Gly Pro 
            100                 105                 110         


Lys Arg Trp Ser Val Ile Ala Lys His Leu Lys Gly Arg Ile Gly Lys 
        115                 120                 125             


Gln Cys Arg Glu Arg Trp His Asn His Leu Asn Pro Glu Val Lys Lys 
    130                 135                 140                 


Thr Ser Trp Thr Glu Glu Glu Asp Arg Ile Ile Tyr Gln Ala His Lys 
145                 150                 155                 160 


Arg Leu Gly Asn Arg Trp Ala Glu Ile Ala Lys Leu Leu Pro Gly Arg 
                165                 170                 175     


Thr Asp Asn Ala Ile Lys Asn His Trp Asn Ser Thr Met Arg Arg Lys 
            180                 185                 190         


Val Glu Gln Glu Gly Tyr Leu Gln Met Ala Leu Glu Asp Arg Cys Ser 
        195                 200                 205             


Pro Gln Ser Ala Pro Ser Pro Ile Thr Leu Gln Met Gln His Leu His 
    210                 215                 220                 


His Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Met Gln His Leu 
225                 230                 235                 240 


His Gln Leu Gln Gln Leu Gln Gln Leu His Gln Gln Gln Leu Ala Ala 
                245                 250                 255     


Gly Val Phe His His Pro Ala Met Ala Phe Asp Ala Ala Ala Ala Ala 
            260                 265                 270         


Ala Ala Ala Ala Ala Ala Ala Ala Ala His Ala His Ala Ala Ala Leu 
        275                 280                 285             


Gln Gln Arg Leu Ser Gly Ser Gly Ser Pro Ala Ser Cys Ser Thr Pro 
    290                 295                 300                 


Ala Ser Ser Thr Pro Leu Thr Ile Lys Glu Glu Glu Ser Asp Ser Val 
305                 310                 315                 320 


Ile Gly Asp Met Ser Phe His Asn Gln Thr His Thr Thr Asn Glu Glu 
                325                 330                 335     


Glu Glu Ala Glu Glu Asp Asp Asp Ile Asp Val Asp Val Asp Asp Thr 
            340                 345                 350         


Ser Ala Gly Gly Arg Leu Pro Pro Pro Ala His Gln Gln Gln Ser Thr 
        355                 360                 365             


Ala Lys Pro Ser Leu Ala Phe Ser Ile Ser Asn Ile Leu Ser Asp Arg 
    370                 375                 380                 


Phe Gly Asp Val Gln Lys Pro Gly Lys Ser Ile Glu Asn Gln Ala Ser 
385                 390                 395                 400 


Ile Phe Arg Pro Phe Glu Ala Asn Arg Ser Gln Thr Ala Thr Pro Ser 
                405                 410                 415     


Ala Phe Thr Arg Val Asp Leu Leu Glu Phe Ser Arg Gln Gln Gln Ala 
            420                 425                 430         


Ala Ala Ala Ala Ala Thr Ala Ala Met Met Leu Glu Arg Ala Asn Phe 
        435                 440                 445             


Leu Asn Cys Phe Asn Pro Ala Ala Tyr Pro Arg Ile His Glu Glu Ile 
    450                 455                 460                 


Val Gln Ser Arg Leu Arg Arg Ser Ala Ala Asn Ala Val Ile Pro Pro 
465                 470                 475                 480 


Pro Met Ser Ser Lys Met Ser Asp Ala Asn Pro Glu Lys Ser Ala Leu 
                485                 490                 495     


Gly Ser 
        


<210>  7
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
agatcttata tggggcaccc ccgccccttg taaacttccc tgaccctgac atgacaagag       60

ttactaacag cccctctctc caagctcact tacaggctct ctacttagtc cagcacgaag      120

tctggagacc tctggcggca gcctaccaag aacaactgga ccgaccggtg gtacctcacc      180

cttaccgagt cggcgacaca gtgtgggtcc gccgacacca gactaagaac ctagaacctc      240

gctggaaagg accttacaca gtcctgctga ccacccccac cgccctcaaa gtagacggca      300

tcgcagcttg gatacacgcc gcccaccatg g                                     331


<210>  8
<211>  2002
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
agatcttata tggggcaccc ccgccccttg taaacttccc tgaccctgac atgacaagag       60

ttactaacag cccctctctc caagctcact tacaggctct ctacttagtc cagcacgaag      120

tctggagacc tctggcggca gcctaccaag aacaactgga ccgaccggtg gtacctcacc      180

cttaccgagt cggcgacaca gtgtgggtcc gccgacacca gactaagaac ctagaacctc      240

gctggaaagg accttacaca gtcctgctga ccacccccac cgccctcaaa gtagacggca      300

tcgcagcttg gatacacgcc gcccaatggg cattgtggaa ccgggctgcg gcgatatgct      360

gaccggcacc gaaccgatgc cgggcagcga tgaaggccgc gcgccgggcg cggatccgca      420

gcatcgctat ttttatccgg aaccgggcgc gcaggatgcg gatgaacgcc gcggcggcgg      480

cagcctgggc agcccgtatc cgggcggcgc gctggtgccg gcgccgccga gccgctttct      540

gggcgcgtat gcgtatccgc cgcgcccgca ggcggcgggc tttccgggcg cgggcgaaag      600

ctttccgccg ccggcggatg cggaaggcta tcagccgggc gaaggctatg cggcgccgga      660

tccgcgcgcg ggcctgtatc cgggcccgcg cgaagattat gcgctgccgg cgggcctgga      720

agtgagcggc aaactgcgcg tggcgctgaa caaccatctg ctgtggagca aatttaacca      780

gcatcagacc gaaatgatta ttaccaaaca gggccgccgc atgtttccgt ttctgagctt      840

taccgtggcg ggcctggaac cgaccagcca ttatcgcatg tttgtggatg tggtgctggt      900

ggatcagcat cattggcgct atcagagcgg caaatgggtg cagtgcggca aagcggaagg      960

cagcatgccg ggcaaccgcc tgtatgtgca tccggatagc ccgaacaccg gcgcgcattg     1020

gatgcgccag gaagtgagct ttggcaaact gaaactgacc aacaacaaag gcgcgagcaa     1080

caacgtgacc cagatgattg tgctgcagag cctgcataaa tatcagccgc gcctgcatat     1140

tgtggaagtg aacgatggcg aaccggaagc ggcgtgcaac gcgagcaaca cccatatttt     1200

tacctttcag gaaacccagt ttattgcggt gaccgcgtat cagaacgcgg aaattaccca     1260

gctgaaaatt gataacaacc cgtttgcgaa aggctttcgc gaaaactttg aaagcatgta     1320

taccagcgtg gataccagca ttccgagccc gccgggcccg aactgccagt ttctgggcgg     1380

cgatcattat agcccgctgc tgccgaacca gtatccggtg ccgagccgct tttatccgga     1440

tctgccgggc caggcgaaag atgtggtgcc gcaggcgtat tggctgggcg cgccgcgcga     1500

tcatagctat gaagcggaat ttcgcgcggt gagcatgaaa ccggcgtttc tgccgagcgc     1560

gccgggcccg accatgagct attatcgcgg ccaggaagtg ctggcgccgg gcgcgggctg     1620

gccggtggcg ccgcagtatc cgccgaaaat gggcccggcg agctggtttc gcccgatgcg     1680

caccctgccg atggaaccgg gcccgggcgg cagcgaaggc cgcggcccgg aagatcaggg     1740

cccgccgctg gtgtggaccg aaattgcgcc gattcgcccg gaaagcagcg atagcggcct     1800

gggcgaaggc gatagcaaac gccgccgcgt gagcccgtat ccgagcagcg gcgatagcag     1860

cagcccggcg ggcgcgccga gcccgtttga taaagaagcg gaaggccagt tttataacta     1920

ttttccgaac ggcagcggcg cgaccaactt tagcctgctg aaacaggcgg gcgatgtgga     1980

agaaaacccg ggcccgccat gg                                              2002


<210>  9
<211>  2407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
agatcttata tggggcaccc ccgccccttg taaacttccc tgaccctgac atgacaagag       60

ttactaacag cccctctctc caagctcact tacaggctct ctacttagtc cagcacgaag      120

tctggagacc tctggcggca gcctaccaag aacaactgga ccgaccggtg gtacctcacc      180

cttaccgagt cggcgacaca gtgtgggtcc gccgacacca gactaagaac ctagaacctc      240

gctggaaagg accttacaca gtcctgctga ccacccccac cgccctcaaa gtagacggca      300

tcgcagcttg gatacacgcc gcccaatggg cattgtggaa ccgggctgcg gcgatatgct      360

gaccggcacc gaaccgatgc cgggcagcga tgaaggccgc gcgccgggcg cggatccgca      420

gcatcgctat ttttatccgg aaccgggcgc gcaggatgcg gatgaacgcc gcggcggcgg      480

cagcctgggc agcccgtatc cgggcggcgc gctggtgccg gcgccgccga gccgctttct      540

gggcgcgtat gcgtatccgc cgcgcccgca ggcggcgggc tttccgggcg cgggcgaaag      600

ctttccgccg ccggcggatg cggaaggcta tcagccgggc gaaggctatg cggcgccgga      660

tccgcgcgcg ggcctgtatc cgggcccgcg cgaagattat gcgctgccgg cgggcctgga      720

agtgagcggc aaactgcgcg tggcgctgaa caaccatctg ctgtggagca aatttaacca      780

gcatcagacc gaaatgatta ttaccaaaca gggccgccgc atgtttccgt ttctgagctt      840

taccgtggcg ggcctggaac cgaccagcca ttatcgcatg tttgtggatg tggtgctggt      900

ggatcagcat cattggcgct atcagagcgg caaatgggtg cagtgcggca aagcggaagg      960

cagcatgccg ggcaaccgcc tgtatgtgca tccggatagc ccgaacaccg gcgcgcattg     1020

gatgcgccag gaagtgagct ttggcaaact gaaactgacc aacaacaaag gcgcgagcaa     1080

caacgtgacc cagatgattg tgctgcagag cctgcataaa tatcagccgc gcctgcatat     1140

tgtggaagtg aacgatggcg aaccggaagc ggcgtgcaac gcgagcaaca cccatatttt     1200

tacctttcag gaaacccagt ttattgcggt gaccgcgtat cagaacgcgg aaattaccca     1260

gctgaaaatt gataacaacc cgtttgcgaa aggctttcgc gaaaactttg aaagcatgta     1320

taccagcgtg gataccagca ttccgagccc gccgggcccg aactgccagt ttctgggcgg     1380

cgatcattat agcccgctgc tgccgaacca gtatccggtg ccgagccgct tttatccgga     1440

tatggcgctg gaagatcgct gcagcccgca gagcgcgccg agcccgatta ccctgcagat     1500

gcagcatctg catcatcagc agcagcagca gcagcagcag cagcagcaga tgcagcatct     1560

gcatcagctg cagcagctgc agcagctgca tcagcagcag ctggcggcgg gcgtgtttca     1620

tcatccggcg atggcgtttg atgcggcggc ggcggcggcg gcggcggcgg cggcggcggc     1680

ggcgcatgcg catgcggcgg cgctgcagca gcgcctgagc ggcagcggca gcccggcgag     1740

ctgcagcacc ccggcgagca gcaccccgct gaccattaaa gaagaagaaa gcgatagcgt     1800

gattggcgat atgagctttc ataaccagac ccataccacc aacgaagaag aagaagcgga     1860

agaagatgat gatattgatg tggatgtgga tgataccagc gcgggcggcc gcctgccgcc     1920

gccggcgcat cagcagcaga gcaccgcgaa accgagcctg gcgtttagca ttagcaacat     1980

tctgagcgat cgctttggcg atgtgcagaa accgggcaaa agcattgaaa accaggcgag     2040

catttttcgc ccgtttgaag cgaaccgcag ccagaccgcg accccgagcg cgtttacccg     2100

cgtggatctg ctggaattta gccgccagca gcaggcggcg gcggcggcgg cgaccgcggc     2160

gatgatgctg gaacgcgcga actttctgaa ctgctttaac ccggcggcgt atccgcgcat     2220

tcatgaagaa attgtgcaga gccgcctgcg ccgcagcgcg gcgaacgcgg tgattccgcc     2280

gccgatgagc agcaaaatga gcgatgcgaa cccggaaaaa agcgcgctgg gcagcggcag     2340

cggcgcgacc aactttagcc tgctgaaaca ggcgggcgat gtggaagaaa acccgggccc     2400

gccatgg                                                               2407


<210>  10
<211>  2455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
agatcttata tggggcaccc ccgccccttg taaacttccc tgaccctgac atgacaagag       60

ttactaacag cccctctctc caagctcact tacaggctct ctacttagtc cagcacgaag      120

tctggagacc tctggcggca gcctaccaag aacaactgga ccgaccggtg gtacctcacc      180

cttaccgagt cggcgacaca gtgtgggtcc gccgacacca gactaagaac ctagaacctc      240

gctggaaagg accttacaca gtcctgctga ccacccccac cgccctcaaa gtagacggca      300

tcgcagcttg gatacacgcc gcccaatgca gctgggcgaa cagctgctgg tgagcagcgt      360

gaacctgccg ggcgcgcatt tttatccgct ggaaagcgcg cgcggcggca gcggcggcag      420

cgcgggccat ctgccgagcg cggcgccgag cccgcagaaa ctggatctgg ataaagcgag      480

caaaaaattt agcggcagcc tgagctgcga agcggtgagc ggcgaaccgg cggcggcgag      540

cgcgggcgcg ccggcggcga tgctgagcga taccgatgcg ggcgatgcgt ttgcgagcgc      600

ggcggcggtg gcgaaaccgg gcccgccgga tggccgcaaa ggcagcccgt gcggcgaaga      660

agaactgccg agcgcggcgg cggcggcggc ggcggcggcg gcggcggcgg cggcgaccgc      720

gcgctatagc atggatagcc tgagcagcga acgctattat ctgcagagcc cgggcccgca      780

gggcagcgaa ctggcggcgc cgtgcagcct gtttccgtat caggcggcgg cgggcgcgcc      840

gcatggcccg gtgtatccgg cgccgaacgg cgcgcgctat ccgtatggca gcatgctgcc      900

gccgggcggc tttccggcgg cggtgtgccc gccgggccgc gcgcagtttg gcccgggcgc      960

gggcgcgggc agcggcgcgg gcggcagcag cggcggcggc ggcggcccgg gcacctatca     1020

gtatagccag ggcgcgccgc tgtatggccc gtatccgggc gcggcggcgg cgggcagctg     1080

cggcggcctg ggcggcctgg gcgtgccggg cagcggcttt cgcgcgcatg tgtatctgtg     1140

caaccgcccg ctgtggctga aatttcatcg ccatcagacc gaaatgatta ttaccaaaca     1200

gggccgccgc atgtttccgt ttctgagctt taacattaac ggcctgaacc cgaccgcgca     1260

ttataacgtg tttgtggaag tggtgctggc ggatccgaac cattggcgct ttcagggcgg     1320

caaatgggtg acctgcggca aagcggataa caacatgcag ggcaacaaaa tgtatgtgca     1380

tccggaaagc ccgaacaccg gcagccattg gatgcgccag gaaattagct ttggcaaact     1440

gaaactgacc aacaacaaag gcgcgaacaa caacaacacc cagatgattg tgctgcagag     1500

cctgcataaa tatcagccgc gcctgcatat tgtggaagtg accgaagatg gcgtggaaga     1560

tctgaacgaa ccgagcaaaa cccagacctt tacctttagc gaaacccagt ttattgcggt     1620

gaccgcgtat cagaacaccg atattaccca gctgaaaatt gatcataacc cgtttgcgaa     1680

aggctttcgc gataactatg atagcagcca tcagattgtg ccgggcggcc gctatggcgt     1740

gcagagcttt tttccggaac cgtttgtgaa caccctgccg caggcgcgct attataacgg     1800

cgaacgcacc gtgccgcaga ccaacggcct gctgagcccg cagcagagcg aagaagtggc     1860

gaacccgccg cagcgctggc tggtgacccc ggtgcagcag ccgggcacca acaaactgga     1920

tattagcagc tatgaaagcg aatataccag cagcaccctg ctgccgtatg gcattaaaag     1980

cctgccgctg cagaccagcc atgcgctggg ctattatccg gatccgacct ttccggcgat     2040

ggcgggctgg ggcggccgcg gcagctatca gcgcaaaatg gcggcgggcc tgccgtggac     2100

cagccgcacc agcccgaccg tgtttagcga agatcagctg agcaaagaaa aagtgaaaga     2160

agaaattggc agcagctgga ttgaaacccc gccgagcatt aaaagcctgg atagcaacga     2220

tagcggcgtg tataccagcg cgtgcaaacg ccgccgcctg agcccgagca acagcagcaa     2280

cgaaaacagc ccgagcatta aatgcgaaga tattaacgcg gaagaatata gcaaagatac     2340

cagcaaaggc atgggcggct attatgcgtt ttataccacc ccgggcagcg gcgcgaccaa     2400

ctttagcctg ctgaaacagg cgggcgatgt ggaagaaaac ccgggcccgc catgg          2455


<210>  11
<211>  2794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
agatcttata tggggcaccc ccgccccttg taaacttccc tgaccctgac atgacaagag       60

ttactaacag cccctctctc caagctcact tacaggctct ctacttagtc cagcacgaag      120

tctggagacc tctggcggca gcctaccaag aacaactgga ccgaccggtg gtacctcacc      180

cttaccgagt cggcgacaca gtgtgggtcc gccgacacca gactaagaac ctagaacctc      240

gctggaaagg accttacaca gtcctgctga ccacccccac cgccctcaaa gtagacggca      300

tcgcagcttg gatacacgcc gcccaatgca gctgggcgaa cagctgctgg tgagcagcgt      360

gaacctgccg ggcgcgcatt tttatccgct ggaaagcgcg cgcggcggca gcggcggcag      420

cgcgggccat ctgccgagcg cggcgccgag cccgcagaaa ctggatctgg ataaagcgag      480

caaaaaattt agcggcagcc tgagctgcga agcggtgagc ggcgaaccgg cggcggcgag      540

cgcgggcgcg ccggcggcga tgctgagcga taccgatgcg ggcgatgcgt ttgcgagcgc      600

ggcggcggtg gcgaaaccgg gcccgccgga tggccgcaaa ggcagcccgt gcggcgaaga      660

agaactgccg agcgcggcgg cggcggcggc ggcggcggcg gcggcggcgg cggcgaccgc      720

gcgctatagc atggatagcc tgagcagcga acgctattat ctgcagagcc cgggcccgca      780

gggcagcgaa ctggcggcgc cgtgcagcct gtttccgtat caggcggcgg cgggcgcgcc      840

gcatggcccg gtgtatccgg cgccgaacgg cgcgcgctat ccgtatggca gcatgctgcc      900

gccgggcggc tttccggcgg cggtgtgccc gccgggccgc gcgcagtttg gcccgggcgc      960

gggcgcgggc agcggcgcgg gcggcagcag cggcggcggc ggcggcccgg gcacctatca     1020

gtatagccag ggcgcgccgc tgtatggccc gtatccgggc gcggcggcgg cgggcagctg     1080

cggcggcctg ggcggcctgg gcgtgccggg cagcggcttt cgcgcgcatg tgtatctgtg     1140

caaccgcccg ctgtggctga aatttcatcg ccatcagacc gaaatgatta ttaccaaaca     1200

gggccgccgc atgtttccgt ttctgagctt taacattaac ggcctgaacc cgaccgcgca     1260

ttataacgtg tttgtggaag tggtgctggc ggatccgaac cattggcgct ttcagggcgg     1320

caaatgggtg acctgcggca aagcggataa caacatgcag ggcaacaaaa tgtatgtgca     1380

tccggaaagc ccgaacaccg gcagccattg gatgcgccag gaaattagct ttggcaaact     1440

gaaactgacc aacaacaaag gcgcgaacaa caacaacacc cagatgattg tgctgcagag     1500

cctgcataaa tatcagccgc gcctgcatat tgtggaagtg accgaagatg gcgtggaaga     1560

tctgaacgaa ccgagcaaaa cccagacctt tacctttagc gaaacccagt ttattgcggt     1620

gaccgcgtat cagaacaccg atattaccca gctgaaaatt gatcataacc cgtttgcgaa     1680

aggctttcgc gataactatg atagcagcca tcagattgtg ccgggcggcc gctatggcgt     1740

gcagagcttt tttccggaac cgtttgtgaa caccctgccg caggcgcgct attataacgg     1800

cgaacgcacc gtgccgcaga ccaacggcat ggcgctggaa gatcgctgca gcccgcagag     1860

cgcgccgagc ccgattaccc tgcagatgca gcatctgcat catcagcagc agcagcagca     1920

gcagcagcag cagcagatgc agcatctgca tcagctgcag cagctgcagc agctgcatca     1980

gcagcagctg gcggcgggcg tgtttcatca tccggcgatg gcgtttgatg cggcggcggc     2040

ggcggcggcg gcggcggcgg cggcggcggc gcatgcgcat gcggcggcgc tgcagcagcg     2100

cctgagcggc agcggcagcc cggcgagctg cagcaccccg gcgagcagca ccccgctgac     2160

cattaaagaa gaagaaagcg atagcgtgat tggcgatatg agctttcata accagaccca     2220

taccaccaac gaagaagaag aagcggaaga agatgatgat attgatgtgg atgtggatga     2280

taccagcgcg ggcggccgcc tgccgccgcc ggcgcatcag cagcagagca ccgcgaaacc     2340

gagcctggcg tttagcatta gcaacattct gagcgatcgc tttggcgatg tgcagaaacc     2400

gggcaaaagc attgaaaacc aggcgagcat ttttcgcccg tttgaagcga accgcagcca     2460

gaccgcgacc ccgagcgcgt ttacccgcgt ggatctgctg gaatttagcc gccagcagca     2520

ggcggcggcg gcggcggcga ccgcggcgat gatgctggaa cgcgcgaact ttctgaactg     2580

ctttaacccg gcggcgtatc cgcgcattca tgaagaaatt gtgcagagcc gcctgcgccg     2640

cagcgcggcg aacgcggtga ttccgccgcc gatgagcagc aaaatgagcg atgcgaaccc     2700

ggaaaaaagc gcgctgggca gcggcagcgg cgcgaccaac tttagcctgc tgaaacaggc     2760

gggcgatgtg gaagaaaacc cgggcccgcc atgg                                 2794


<210>  12
<211>  2317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
agatcttata tggggcaccc ccgccccttg taaacttccc tgaccctgac atgacaagag       60

ttactaacag cccctctctc caagctcact tacaggctct ctacttagtc cagcacgaag      120

tctggagacc tctggcggca gcctaccaag aacaactgga ccgaccggtg gtacctcacc      180

cttaccgagt cggcgacaca gtgtgggtcc gccgacacca gactaagaac ctagaacctc      240

gctggaaagg accttacaca gtcctgctga ccacccccac cgccctcaaa gtagacggca      300

tcgcagcttg gatacacgcc gcccaatggc gcgccgcccg cgccatagca tttatagcag      360

cgatgaagat gatgaagatt ttgaaatgtg cgatcatgat tatgatggcc tgctgccgaa      420

aagcggcaaa cgccatctgg gcaaaacccg ctggacccgc gaagaagatg aaaaactgaa      480

aaaactggtg gaacagaacg gcaccgatga ttggaaagtg attgcgaact atctgccgaa      540

ccgcaccgat gtgcagtgcc agcatcgctg gcagaaagtg ctgaacccgg aactgattaa      600

aggcccgtgg accaaagaag aagatcagcg cgtgattgaa ctggtgcaga aatatggccc      660

gaaacgctgg agcgtgattg cgaaacatct gaaaggccgc attggcaaac agtgccgcga      720

acgctggcat aaccatctga acccggaagt gaaaaaaacc agctggaccg aagaagaaga      780

tcgcattatt tatcaggcgc ataaacgcct gggcaaccgc tgggcggaaa ttgcgaaact      840

gctgccgggc cgcaccgata acgcgattaa aaaccattgg aacagcacca tgcgccgcaa      900

agtggaacag gaaggctatc tgcaggaaag cagcaaagcg agccagccgg cggtggcgac      960

cagctttcag aaaaacagcc atctgatggg ctttgcgcag gcgccgccga ccgcgcagct     1020

gccggcgacc ggccagccga ccgtgaacaa cgattatagc tattatcata ttagcgaagc     1080

gcagaacgtg agcagccatg tgccgtatcc ggtggcgctg catgtgaaca ttgtgaacgt     1140

gccgcagccg gcggcggcgg cgattcagcg ccattataac gatgaagatc cggaaaaaga     1200

aaaacgcatt aaagaactgg aactgctgct gatgagcacc gaaaacgaac tgaaaggcca     1260

gcaggtgctg ccgacccaga accatacctg cagctatccg ggctggcata gcaccaccat     1320

tgcggatcat acccgcccgc atggcgatag cgcgccggtg agctgcctgg gcgaacatca     1380

tagcaccccg agcctgccgg cggatccggg cagcctgccg gaagaaagcg cgagcccggc     1440

gcgctgcatg attgtgcatc agggcaccat tctggataac gtgaaaaacc tgctggaatt     1500

tgcggaaacc ctgcagttta ttgatagctt tctgaacacc agcagcaacc atgaaaacag     1560

cgatctggaa atgccgagcc tgaccagcac cccgctgatt ggccataaac tgaccgtgac     1620

caccccgttt catcgcgatc agaccgtgaa aacccagaaa gaaaacaccg tgtttcgcac     1680

cccggcgatt aaacgcagca ttctggaaag cagcccgcgc accccgaccc cgtttaaaca     1740

tgcgctggcg gcgcaggaaa ttaaatatgg cccgctgaaa atgctgccgc agaccccgag     1800

ccatctggtg gaagatctgc aggatgtgat taaacaggaa agcgatgaaa gcggcattgt     1860

ggcggaattt caggaaaacg gcccgccgct gctgaaaaaa attaaacagg aagtggaaag     1920

cccgaccgat aaaagcggca actttttttg cagccatcat tgggaaggcg atagcctgaa     1980

cacccagctg tttacccaga ccagcccggt ggcggatgcg ccgaacattc tgaccagcag     2040

cgtgctgatg gcgccggcga gcgaagatga agataacgtg ctgaaagcgt ttaccgtgcc     2100

gaaaaaccgc agcctggcga gcccgctgca gccgtgcagc agcacctggg aaccggcgag     2160

ctgcggcaaa atggaagaac agatgaccag cagcagccag gcgcgcaaat atgtgaacgc     2220

gtttagcgcg cgcaccctgg tgatgggcag cggcgcgacc aactttagcc tgctgaaaca     2280

ggcgggcgat gtggaagaaa acccgggccc gccatgg                              2317


<210>  13
<211>  1891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
agatcttata tggggcaccc ccgccccttg taaacttccc tgaccctgac atgacaagag       60

ttactaacag cccctctctc caagctcact tacaggctct ctacttagtc cagcacgaag      120

tctggagacc tctggcggca gcctaccaag aacaactgga ccgaccggtg gtacctcacc      180

cttaccgagt cggcgacaca gtgtgggtcc gccgacacca gactaagaac ctagaacctc      240

gctggaaagg accttacaca gtcctgctga ccacccccac cgccctcaaa gtagacggca      300

tcgcagcttg gatacacgcc gcccaatggc gcgccgcccg cgccatagca tttatagcag      360

cgatgaagat gatgaagatt ttgaaatgtg cgatcatgat tatgatggcc tgctgccgaa      420

aagcggcaaa cgccatctgg gcaaaacccg ctggacccgc gaagaagatg aaaaactgaa      480

aaaactggtg gaacagaacg gcaccgatga ttggaaagtg attgcgaact atctgccgaa      540

ccgcaccgat gtgcagtgcc agcatcgctg gcagaaagtg ctgaacccgg aactgattaa      600

aggcccgtgg accaaagaag aagatcagcg cgtgattgaa ctggtgcaga aatatggccc      660

gaaacgctgg agcgtgattg cgaaacatct gaaaggccgc attggcaaac agtgccgcga      720

acgctggcat aaccatctga acccggaagt gaaaaaaacc agctggaccg aagaagaaga      780

tcgcattatt tatcaggcgc ataaacgcct gggcaaccgc tgggcggaaa ttgcgaaact      840

gctgccgggc cgcaccgata acgcgattaa aaaccattgg aacagcacca tgcgccgcaa      900

agtggaacag gaaggctatc tgcagatggc gctggaagat cgctgcagcc cgcagagcgc      960

gccgagcccg attaccctgc agatgcagca tctgcatcat cagcagcagc agcagcagca     1020

gcagcagcag cagatgcagc atctgcatca gctgcagcag ctgcagcagc tgcatcagca     1080

gcagctggcg gcgggcgtgt ttcatcatcc ggcgatggcg tttgatgcgg cggcggcggc     1140

ggcggcggcg gcggcggcgg cggcggcgca tgcgcatgcg gcggcgctgc agcagcgcct     1200

gagcggcagc ggcagcccgg cgagctgcag caccccggcg agcagcaccc cgctgaccat     1260

taaagaagaa gaaagcgata gcgtgattgg cgatatgagc tttcataacc agacccatac     1320

caccaacgaa gaagaagaag cggaagaaga tgatgatatt gatgtggatg tggatgatac     1380

cagcgcgggc ggccgcctgc cgccgccggc gcatcagcag cagagcaccg cgaaaccgag     1440

cctggcgttt agcattagca acattctgag cgatcgcttt ggcgatgtgc agaaaccggg     1500

caaaagcatt gaaaaccagg cgagcatttt tcgcccgttt gaagcgaacc gcagccagac     1560

cgcgaccccg agcgcgttta cccgcgtgga tctgctggaa tttagccgcc agcagcaggc     1620

ggcggcggcg gcggcgaccg cggcgatgat gctggaacgc gcgaactttc tgaactgctt     1680

taacccggcg gcgtatccgc gcattcatga agaaattgtg cagagccgcc tgcgccgcag     1740

cgcggcgaac gcggtgattc cgccgccgat gagcagcaaa atgagcgatg cgaacccgga     1800

aaaaagcgcg ctgggcagcg gcagcggcgc gaccaacttt agcctgctga aacaggcggg     1860

cgatgtggaa gaaaacccgg gcccgccatg g                                    1891


