                         SEQUENCE LISTING

<110>  TRUSTEES OF TUFTS COLLEGE
 
<120>  ANTI-ADAM8 ANTIBODIES AND USES OF THE SAME

<130>  46700-0002WO1

<150>  62/855,575
<151>  2019-05-31

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn Arg Cys Cys Asn Ser Thr 
1               5                   10                  15      


Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys Ala His Gly Thr Cys Cys 
            20                  25                  30          


Gln Glu Cys Lys Val Lys Pro Ala Gly Glu Leu Cys Arg Pro Lys Lys 
        35                  40                  45              


Asp Met Cys Asp Leu Glu Glu Phe Cys Asp Gly Arg His Pro Glu Cys 
    50                  55                  60                  


Pro Glu Asp Ala Phe 
65                  


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  2

Gly Phe Ser Phe Pro Asp Tyr Tyr 
1               5               


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  3

Ile Arg Asp Ser Ala Asn Gly Tyr Thr Thr 
1               5                   10  


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  4

Ala Arg Tyr Ser Arg Tyr Tyr Gly Met Asp Tyr 
1               5                   10      


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  5

Gln Thr Val Asn Tyr Asp 
1               5       


<210>  6
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  6

Phe Ala Ser 
1           


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  7

Gln Gln Asp Tyr Ser Ala Pro Trp Thr 
1               5                   


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  8

Ser Ile Val Met Thr Gln Thr Pro Lys Ile Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Thr Val Asn Tyr Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Val Ile 
        35                  40                  45              


Tyr Phe Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  9
agtattgtga tgacccagac tcccaaaatc ctgcttgtgt cagcaggaga cagggttacc       60

ataacctgca aggccagtca gactgtgaat tatgatgtag cttggtacca acagaagcca      120

gggcagtctc ctaaaccggt gatatacttt gcatccaatc gctacactgg ggtccctgat      180

cgcttcactg gcagtggatt tgggacggat ttcactttca ccatcagcac tgtgcaggct      240

gaagacctgg cagtttattt ctgtcagcag gattatagtg ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  10
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  10

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asp Ser Ala Asn Gly Tyr Thr Thr Glu Tyr Ile Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Tyr Ser Arg Tyr Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  11
gaggtgaagc tggtggagtc tggaggaggc ttggtacagc ctgggggttc tctgagtctc       60

tcctgtgcag cttctggatt ctccttccct gattactaca tgagctgggt ccgccagcct      120

ccagggaagg cacttgagtg gttgggtttt attagagaca gtgctaatgg ttacacaaca      180

gagtacattg catctgtcaa gggtcggttc accttctcca gagataattc ccaaagcatc      240

ctctatcttc aaatgaatgc cctgagagct gaggacagtg ccacttatta ctgtgcaaga      300

tatagccgat actatggtat ggactattgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  12

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  13

Ile Ser Pro Asn Ile Gly Gly Ala 
1               5               


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  14

Thr Arg Gly Gly Ser Ser Tyr Pro Tyr Phe Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  15

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Lys Tyr 
1               5                   10          


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  16

Trp Ala Ser 
1           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  17

Gln Gln Phe Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  18
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  18

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Asn Arg 
        


<210>  19
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  19
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa gtacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaattgttga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaatt ttatagctat      300

ccgtacacgt tcggaggggg gaccaagctg gaaataaacc gg                         342


<210>  20
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  20

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Met Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Ser Pro Asn Ile Gly Gly Ala Thr Tyr Asn Pro Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ala Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Cys Cys 
                85                  90                  95      


Thr Arg Gly Gly Ser Ser Tyr Pro Tyr Phe Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  21
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  21
gaggtccagc tgcaacaatc tggacctgaa atggtgaagc ctgggacttc agtgaagata       60

tcgtgtaagg cttctggata cacgttcact gactactaca taaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attagtccta acattggtgg tgcgacctac      180

aacccgaagt tcaagggcaa ggccatattg actgtagaca agtccgccag aacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attgctgtac aagaggcggt      300

agtagctacc cctatttcta tgctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  22

Gly Phe Thr Phe Ser Asp Ala Trp 
1               5               


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  23

Ile Arg Gly Lys Val Asn Asn Leu Ala Thr 
1               5                   10  


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  24

Leu Gly Arg Tyr Asp Ala Thr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  25

Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  26
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  26

Lys Leu Ser 
1           


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  27

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  28
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  28

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Leu Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  29
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtgatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaactttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  30
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  30

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Gly Lys Val Asn Asn Leu Ala Thr Tyr Tyr Val Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Leu Gly Arg Tyr Asp Ala Thr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  31
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcttgtgctg cctctggatt cacttttagt gacgcctgga tggactgggt ccgccagtct      120

ccagagaagg gacttgagtg ggttgctgaa attagaggca aagttaataa tcttgcaacg      180

tactatgttg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtagt      240

gtctacctgc aaatgaacag cttaagagct gaagacactg gcatttatta ctgtttgggg      300

aggtacgacg cgacatatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  32

Gly Phe Ser Phe Thr Asp Tyr Tyr 
1               5               


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  33

Ile Arg Asp Ser Ala Asn Gly Tyr Thr Ala 
1               5                   10  


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  34

Ala Arg Tyr Ser Arg Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  35

Gln Ser Val Asn Tyr Asp 
1               5       


<210>  36
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  36

Phe Ala Ser 
1           


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  37

Gln Gln Asp Tyr Ser Ser Pro Trp Thr 
1               5                   


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  38

Phe Ile Val Met Thr Gln Thr Pro Lys Ile Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asn Tyr Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Val Ile 
        35                  40                  45              


Tyr Phe Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  39
tttattgtga tgacccagac tcccaaaatc ctgcttgtat cagcaggaga caggatcacc       60

ataacctgca aggccagtca gagtgtgaat tatgatgtcg cttggtacca acagaagcca      120

gggcagtctc ctaaaccggt gatatacttt gcatccaatc gctacactgg agtccctgat      180

cgcttcactg gcagtggatt tgggacggat ttcactttca ccatcagcac tgtgcaggct      240

gaagacctgg cagtttattt ctgtcagcag gattatagct ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  40
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  40

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Glu Thr Ser Gly Phe Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ile Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asp Ser Ala Asn Gly Tyr Thr Ala Glu Tyr Ile Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Tyr Ser Arg Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ala Pro 
        115                 120 


<210>  41
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  41
gaggtgaagc tggtggagtc tggaggaggc ttggtacagc ctgggggttc tctgagtctc       60

tcctgtgaaa cttctggatt ctccttcact gattactata tgatctgggt ccgccagcct      120

ccagggaagg cacttgagtg gttgggtttt atcagagaca gtgctaatgg ttacacagca      180

gagtacattg catctgtgaa gggtcggttc accttctcca gagataattc ccaaagcatc      240

ctctatcttc aaatgaatgc cctgagagct gaggacagtg ccacttatta ctgtgcaaga      300

tatagccgat actatgctat ggactattgg ggtcagggaa cctcagtcac cgtcgcccca      360


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  42

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  43

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  44

Ala Arg Lys Arg Gly Leu Gly Gln Ala Trp Leu Ala Tyr 
1               5                   10              


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  45

Gln Ser Leu Leu Tyr Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  46
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  46

Gly Ala Ser 
1           


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  47

Gln Asn Asp His Ser Tyr Pro Leu Thr 
1               5                   


<210>  48
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Arg Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  49
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  49
gacattgtga tgacacagtc tccatcctcc cggagtgtgt cagcaggaga gaaggtcact       60

atgagctgca agtccagcca gagtctgtta tacagtggaa atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagttat      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  50
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  50

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Arg Gly Leu Gly Gln Ala Trp Leu Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  51
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  51
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

ccctgcaagg cttctggata cacattcact gactacaaca tggactgggt gaagcagagc      120

catggaaaga gccttgactg gattggagat attaatccaa acaatggtgg tactatctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac actgcagtct attactgtgc aagaaagaga      300

ggcctgggac aggcctggtt agcttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  52

Gly Phe Thr Phe Ser Tyr Ala Trp 
1               5               


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  53

Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  54

Met Gly Arg Tyr Asp Ala Ala Tyr Gly Met Asp Tyr 
1               5                   10          


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  55

Gln Ser Leu Val His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  56
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  56

Lys Val Ser 
1           


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  57

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  58
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  58

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Tyr Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  59
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  59
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggata tcaagcctcc       60

atctcttgca gatctagtca gagccttgtt cacagcaatg gaatcaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  60
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  60

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ile Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Met Gly Arg Tyr Asp Ala Ala Tyr Gly Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  61
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  61
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcttgtgctg cctctggatt cacttttagt tacgcctgga tggactgggt ccgccagtct      120

cccgagaagg gacttgagtg ggttgctgaa attagaagca aagctaataa ttatgcaaca      180

tactatgctg agtctgtgaa agggaggttc accatctcaa gaaatgattc caaaagtagt      240

gtctacctac aaatgaacag cttgagaatt gaagacactg gcatttatta ctgtatgggg      300

aggtacgacg cggcctatgg tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  62

Gly Phe Thr Phe Ser Asp Ala Trp 
1               5               


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  63

Ile Arg Asn Lys Ala Asn Ser His Ala Thr 
1               5                   10  


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  64

Thr Arg Asp Gly Gly Tyr Tyr Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  65

Gln Ser Ile Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  66
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  66

Arg Val Ser 
1           


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  67

Phe His Gly Ser His Ile Pro Leu Thr 
1               5                   


<210>  68
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  68

Gly Ala Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe His Gly 
                85                  90                  95      


Ser His Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  69
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  69
ggtgctttgc tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagtctcc       60

atctcttgca ggtctagtca gagcattgta catagtgatg gaaacaccta tttagaatgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgattt acagagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagacttcac actcaagatc      240

agcagagtgg aggctgagga tctgggaatt tattactgct ttcacggttc acatattccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  70
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  70

Glu Val Lys Phe Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Asn Lys Ala Asn Ser His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Gly Gly Tyr Tyr Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  71
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  71
gaagtgaagt ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcttgtgctg cctctggatt cacttttagt gacgcctgga tggactgggt ccgccagtct      120

ccagagaagg ggcttgagtg ggttgctgaa attagaaaca aagctaatag tcatgcaaca      180

tactatgctg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtact      240

gtctacctgc aaatgaacag cttaagagct gaagacactg gcatttatta ctgtaccagg      300

gatggtggtt actacgcctg gtttgcttac tggggccaag ggactctggt cactgtctct      360

gca                                                                    363


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  72

Gly Phe Thr Phe Ser Asp Ala Trp 
1               5               


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  73

Ile Arg Asn Lys Ala Asn Asn His Ala Thr 
1               5                   10  


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  74

Thr Arg Asp Gly Gly Tyr Tyr Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  75

Gln Ser Ile Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  76
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  76

Lys Val Ser 
1           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  77

Phe His Gly Ser His Ile Pro Leu Thr 
1               5                   


<210>  78
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  78

Gly Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Leu Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe His Gly 
                85                  90                  95      


Ser His Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  79
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  79
ggtgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca ggtctagtca gagcattgta catagtgatg gaaacaccta tttagaatgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgctct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcatggttc acatattccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  80
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  80

Glu Val Lys Phe Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Asn Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Gly Gly Tyr Tyr Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  81
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  81
gaagtgaagt ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcttgtgctg cctctggatt cacttttagt gacgcctgga tggactgggt ccgccagtct      120

ccagagaagg ggcttgagtg ggttgctgaa attagaaaca aagctaataa tcatgcaaca      180

tactatgctg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtagt      240

gtctacctgc aaatgaacag tttaagagct gaagacactg gcatttatta ctgtaccagg      300

gatggtggtt actacgcctg gtttgcttac tggggccaag ggactctggt cactgtctct      360

gca                                                                    363


<210>  82
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  82

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asp Ser Ala Asn Gly Tyr Thr Thr Glu Tyr Ile Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Tyr Ser Arg Tyr Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  83
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  83

Ser Ile Val Met Thr Gln Thr Pro Lys Ile Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Thr Val Asn Tyr Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Val Ile 
        35                  40                  45              


Tyr Phe Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  84
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  84

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Met Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Ser Pro Asn Ile Gly Gly Ala Thr Tyr Asn Pro Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ala Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Cys Cys 
                85                  90                  95      


Thr Arg Gly Gly Ser Ser Tyr Pro Tyr Phe Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  85
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  85

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Lys Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  86
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  86

Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys Ala 
1               5                   10                  15      


His Gly Thr Cys Cys Gln Glu Cys Lys 
            20                  25  


<210>  87
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  87

Leu Ala Glu Gly Ala Gln Cys Ala His Gly Thr Cys Cys Gln Glu Cys 
1               5                   10                  15      


Lys Val Lys Pro Ala Gly Glu Leu Cys Arg Pro Lys Lys Asp Met Cys 
            20                  25                  30          


Asp Leu Glu Glu Phe Cys Asp Gly Arg His Pro Glu Cys Pro Glu Asp 
        35                  40                  45              


Ala Phe 
    50  


<210>  88
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  88

Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn Arg Cys Cys Asn Ser Thr 
1               5                   10                  15      


Thr Cys Gln 
            


<210>  89
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  89

Cys Arg Pro Lys Lys Asp Met Cys Asp 
1               5                   


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(4)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (6)..(7)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (9)..(10)
<223>  Any amino acid

<400>  90

His Glu Xaa Xaa His Xaa Xaa Gly Xaa Xaa His 
1               5                   10      


<210>  91
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Phe Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Thr Ala Pro 
            820                 


<210>  92
<211>  2475
<212>  DNA
<213>  Homo sapiens

<400>  92
atgcgcggcc tcgggctctg gctgctgggc gcgatgatgc tgcctgcgat tgcccccagc       60

cggccctggg ccctcatgga gcagtatgag gtcgtgttgc cgtggcgtct gccaggcccc      120

cgagtccgcc gagctctgcc ctcccacttg ggcctgcacc cagagagggt gagctacgtc      180

cttggggcca cagggcacaa cttcaccctc cacctgcgga agaacaggga cctgctgggc      240

tccggctaca cagagaccta tacggctgcc aatggctccg aggtgacgga gcagcctcgc      300

gggcaggacc actgcttcta ccagggccac gtagaggggt acccggactc agccgccagc      360

ctcagcacct gtgccggcct caggggtttc ttccaggtgg ggtcagacct gcacctgatc      420

gagcccctgg atgaaggtgg cgagggcgga cggcacgccg tgtaccaggc tgagcacctg      480

ctgcagacgg ccgggacctg cggggtcagc gacgacagcc tgggcagcct cctgggaccc      540

cggacggcag ccgtcttcag gcctcggccc ggggactctc tgccatcccg agagacccgc      600

tacgtggagc tgtatgtggt cgtggacaat gcagagttcc agatgctggg gagcgaagca      660

gccgtgcgtc atcgggtgct ggaggtggtg aatcacgtgg acaagctata tcagaaactc      720

aacttccgtg tggtcctggt gggcctggag atttggaata gtcaggacag gttccacgtc      780

agccccgacc ccagtgtcac actggagaac ctcctgacct ggcaggcacg gcaacggaca      840

cggcggcacc tgcatgacaa cgtacagctc atcacgggtg tcgacttcac cgggactacc      900

gtggggtttg ccagggtgtc cgccatgtgc tcccacagct caggggctgt gaaccaggac      960

cacagcaaga accccgtggg cgtggcctgt accatggccc atgagatggg ccacaacctg     1020

ggcatggacc atgatgagaa cgtccagggc tgccgctgcc aggaacgctt cgaggccggc     1080

cgctgcatca tggcgggcag cattggctcc agtttcccca ggatgttcag tgactgcagc     1140

caggcctacc tggagagctt tttggagcgg ccgcagtcgg tgtgcctcgc caacgcccct     1200

gacctcagcc acctggtggg cggccccgtg tgtgggaacc tgtttgtgga gcgtggggag     1260

cagtgcgact gcggcccccc cgaggactgc cggaaccgct gctgcaactc taccacctgc     1320

cagctggctg agggggccca gtgtgcgcac ggtacctgct gccaggagtg caaggtgaag     1380

ccggctggtg agctgtgccg tcccaagaag gacatgtgtg acctcgagga gttctgtgac     1440

ggccggcacc ctgagtgccc ggaagacgcc ttccaggaga acggcacgcc ctgctccggg     1500

ggctactgct acaacggggc ctgtcccaca ctggcccagc agtgccaggc cttctggggg     1560

ccaggtgggc aggctgccga ggagtcctgc ttctcctatg acatcctacc aggctgcaag     1620

gccagccggt acagggctga catgtgtggc gttctgcagt gcaagggtgg gcagcagccc     1680

ctggggcgtg ccatctgcat cgtggatgtg tgccacgcgc tcaccacaga ggatggcact     1740

gcgtatgaac cagtgcccga gggcacccgg tgtggaccag agaaggtttg ctggaaagga     1800

cgttgccagg acttacacgt ttacagatcc agcaactgct ctgcccagtg ccacaaccat     1860

ggggtgtgca accacaagca ggagtgccac tgccacgcgg gctgggcccc gccccactgc     1920

gcgaagctgc tgactgaggt gcacgcagcg tccgggagcc tccccgtctt cgtggtggtg     1980

gttctggtgc tcctggcagt tgtgctggtc accctggcag gcatcatcgt ctaccgcaaa     2040

gcccggagcc gcatcctgag caggaacgtg gctcccaaga ccacaatggg gcgctccaac     2100

cccctgttcc accaggctgc cagccgcgtg ccggccaagg gcggggctcc agccccatcc     2160

aggggccccc aagagctggt ccccaccacc cacccgggcc agcccgcccg acacccggcc     2220

tcctcggtgg ctctgaagag gccgccccct gctcctccgg tcactgtgtc cagcccaccc     2280

ttcccagttc ctgtctacac ccggcaggca ccaaagcagg tcatcaagcc aacgttcgca     2340

cccccagtgc ccccagtcaa acccggggct ggtgcggcca accctggtcc agctgagggt     2400

gctgttggcc caaaggttgc cctgaagccc cccatccaga ggaagcaagg agccggagct     2460

cccacagcac cctag                                                      2475


<210>  93
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Gly Cys Gln Pro Arg Ala Gly 
                645                 650                 655     


Gln Gly Arg Gly Ser Ser Pro Ile Gln Gly Pro Pro Arg Ala Gly Pro 
            660                 665                 670         


His His Pro Pro Gly Pro Ala Arg Pro Thr Pro Gly Leu Leu Gly Gly 
        675                 680                 685             


Ser Glu Glu Ala Ala Pro Cys Ser Ser Gly His Cys Val Gln Pro Thr 
    690                 695                 700                 


Leu Pro Ser Ser Cys Leu His Pro Ala Gly Thr Lys Ala Gly His Gln 
705                 710                 715                 720 


Ala Asn Val Arg Thr Pro Ser Ala Pro Ser Gln Thr Arg Gly Trp Cys 
                725                 730                 735     


Gly Gln Pro Trp Ser Ser 
            740         


<210>  94
<211>  2229
<212>  DNA
<213>  Homo sapiens

<400>  94
atgcgcggcc tcgggctctg gctgctgggc gcgatgatgc tgcctgcgat tgcccccagc       60

cggccctggg ccctcatgga gcagtatgag gtcgtgttgc cgtggcgtct gccaggcccc      120

cgagtccgcc gagctctgcc ctcccacttg ggcctgcacc cagagagggt gagctacgtc      180

cttggggcca cagggcacaa cttcaccctc cacctgcgga agaacaggga cctgctgggc      240

tccggctaca cagagaccta tacggctgcc aatggctccg aggtgacgga gcagcctcgc      300

gggcaggacc actgcttcta ccagggccac gtagaggggt acccggactc agccgccagc      360

ctcagcacct gtgccggcct caggggtttc ttccaggtgg ggtcagacct gcacctgatc      420

gagcccctgg atgaaggtgg cgagggcgga cggcacgccg tgtaccaggc tgagcacctg      480

ctgcagacgg ccgggacctg cggggtcagc gacgacagcc tgggcagcct cctgggaccc      540

cggacggcag ccgtcttcag gcctcggccc ggggactctc tgccatcccg agagacccgc      600

tacgtggagc tgtatgtggt cgtggacaat gcagagttcc agatgctggg gagcgaagca      660

gccgtgcgtc atcgggtgct ggaggtggtg aatcacgtgg acaagctata tcagaaactc      720

aacttccgtg tggtcctggt gggcctggag atttggaata gtcaggacag gttccacgtc      780

agccccgacc ccagtgtcac actggagaac ctcctgacct ggcaggcacg gcaacggaca      840

cggcggcacc tgcatgacaa cgtacagctc atcacgggtg tcgacttcac cgggactacc      900

gtggggtttg ccagggtgtc cgccatgtgc tcccacagct caggggctgt gaaccaggac      960

cacagcaaga accccgtggg cgtggcctgt accatggccc atgagatggg ccacaacctg     1020

ggcatggacc atgatgagaa cgtccagggc tgccgctgcc aggaacgctt cgaggccggc     1080

cgctgcatca tggcgggcag cattggctcc agtttcccca ggatgttcag tgactgcagc     1140

caggcctacc tggagagctt tttggagcgg ccgcagtcgg tgtgcctcgc caacgcccct     1200

gacctcagcc acctggtggg cggccccgtg tgtgggaacc tgtttgtgga gcgtggggag     1260

cagtgcgact gcggcccccc cgaggactgc cggaaccgct gctgcaactc taccacctgc     1320

cagctggctg agggggccca gtgtgcgcac ggtacctgct gccaggagtg caaggtgaag     1380

ccggctggtg agctgtgccg tcccaagaag gacatgtgtg acctcgagga gttctgtgac     1440

ggccggcacc ctgagtgccc ggaagacgcc ttccaggaga acggcacgcc ctgctccggg     1500

ggctactgct acaacggggc ctgtcccaca ctggcccagc agtgccaggc cttctggggg     1560

ccaggtgggc aggctgccga ggagtcctgc ttctcctatg acatcctacc aggctgcaag     1620

gccagccggt acagggctga catgtgtggc gttctgcagt gcaagggtgg gcagcagccc     1680

ctggggcgtg ccatctgcat cgtggatgtg tgccacgcgc tcaccacaga ggatggcact     1740

gcgtatgaac cagtgcccga gggcacccgg tgtggaccag agaaggtttg ctggaaagga     1800

cgttgccagg acttacacgt ttacagatcc agcaactgct ctgcccagtg ccacaaccat     1860

ggggtgtgca accacaagca ggagtgccac tgccacgcgg gctgggcccc gccccactgc     1920

gcgaagctgc tgactgaggt gcacgcaggc tgccagccgc gtgccggcca agggcggggc     1980

tccagcccca tccaggggcc cccaagagct ggtccccacc acccacccgg gccagcccgc     2040

ccgacacccg gcctcctcgg tggctctgaa gaggccgccc cctgctcctc cggtcactgt     2100

gtccagccca cccttcccag ttcctgtcta cacccggcag gcaccaaagc aggtcatcaa     2160

gccaacgttc gcacccccag tgcccccagt caaacccggg gctggtgcgg ccaaccctgg     2220

tccagctga                                                             2229


<210>  95
<211>  733
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Gly 
1               5                   10                  15      


Pro Ala Pro Arg Glu Gly Glu Leu Arg Pro Trp Gly His Arg Ala Gln 
            20                  25                  30          


Leu His Pro Pro Pro Ala Glu Glu Gln Gly Pro Ala Gly Leu Arg Leu 
        35                  40                  45              


His Arg Asp Leu Tyr Gly Cys Gln Trp Leu Arg Gly Asp Gly Ala Ala 
    50                  55                  60                  


Ser Arg Ala Gly Pro Leu Leu Leu Pro Gly Pro Arg Arg Gly Val Pro 
65                  70                  75                  80  


Gly Leu Ser Arg Gln Pro Gln His Leu Cys Arg Pro Gln Val Gly Ser 
                85                  90                  95      


Asp Leu His Leu Ile Glu Pro Leu Asp Glu Gly Gly Glu Gly Gly Arg 
            100                 105                 110         


His Ala Val Tyr Gln Ala Glu His Leu Leu Gln Thr Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Ser Asp Asp Ser Leu Gly Ser Leu Leu Gly Pro Arg Thr Ala 
    130                 135                 140                 


Ala Val Phe Arg Pro Arg Pro Gly Asp Ser Leu Pro Ser Arg Glu Thr 
145                 150                 155                 160 


Arg Tyr Val Glu Leu Tyr Val Val Val Asp Asn Ala Glu Phe Gln Met 
                165                 170                 175     


Leu Gly Ser Glu Ala Ala Val Arg His Arg Val Leu Glu Val Val Asn 
            180                 185                 190         


His Val Asp Lys Leu Tyr Gln Lys Leu Asn Phe Arg Val Val Leu Val 
        195                 200                 205             


Gly Leu Glu Ile Trp Asn Ser Gln Asp Arg Phe His Val Ser Pro Asp 
    210                 215                 220                 


Pro Ser Val Thr Leu Glu Asn Leu Leu Thr Trp Gln Ala Arg Gln Arg 
225                 230                 235                 240 


Thr Arg Arg His Leu His Asp Asn Val Gln Leu Ile Thr Gly Val Asp 
                245                 250                 255     


Phe Thr Gly Thr Thr Val Gly Phe Ala Arg Val Ser Ala Met Cys Ser 
            260                 265                 270         


His Ser Ser Gly Ala Val Asn Gln Asp His Ser Lys Asn Pro Val Gly 
        275                 280                 285             


Val Ala Cys Thr Met Ala His Glu Met Gly His Asn Leu Gly Met Asp 
    290                 295                 300                 


His Asp Glu Asn Val Gln Gly Cys Arg Cys Gln Glu Arg Phe Glu Ala 
305                 310                 315                 320 


Gly Arg Cys Ile Met Ala Gly Ser Ile Gly Ser Ser Phe Pro Arg Met 
                325                 330                 335     


Phe Ser Asp Cys Ser Gln Ala Tyr Leu Glu Ser Phe Leu Glu Arg Pro 
            340                 345                 350         


Gln Ser Val Cys Leu Ala Asn Ala Pro Asp Leu Ser His Leu Val Gly 
        355                 360                 365             


Gly Pro Val Cys Gly Asn Leu Phe Val Glu Arg Gly Glu Gln Cys Asp 
    370                 375                 380                 


Cys Gly Pro Pro Glu Asp Cys Arg Asn Arg Cys Cys Asn Ser Thr Thr 
385                 390                 395                 400 


Cys Gln Leu Ala Glu Gly Ala Gln Cys Ala His Gly Thr Cys Cys Gln 
                405                 410                 415     


Glu Cys Lys Val Lys Pro Ala Gly Glu Leu Cys Arg Pro Lys Lys Asp 
            420                 425                 430         


Met Cys Asp Leu Glu Glu Phe Cys Asp Gly Arg His Pro Glu Cys Pro 
        435                 440                 445             


Glu Asp Ala Phe Gln Glu Asn Gly Thr Pro Cys Ser Gly Gly Tyr Cys 
    450                 455                 460                 


Tyr Asn Gly Ala Cys Pro Thr Leu Ala Gln Gln Cys Gln Ala Phe Trp 
465                 470                 475                 480 


Gly Pro Gly Gly Gln Ala Ala Glu Glu Ser Cys Phe Ser Tyr Asp Ile 
                485                 490                 495     


Leu Pro Gly Cys Lys Ala Ser Arg Tyr Arg Ala Asp Met Cys Gly Val 
            500                 505                 510         


Leu Gln Cys Lys Gly Gly Gln Gln Pro Leu Gly Arg Ala Ile Cys Ile 
        515                 520                 525             


Val Asp Val Cys His Ala Leu Thr Thr Glu Asp Gly Thr Ala Tyr Glu 
    530                 535                 540                 


Pro Val Pro Glu Gly Thr Arg Cys Gly Pro Glu Lys Val Cys Asn His 
545                 550                 555                 560 


Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys Ala 
                565                 570                 575     


Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val Phe 
            580                 585                 590         


Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu Ala 
        595                 600                 605             


Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg Asn 
    610                 615                 620                 


Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His Gln 
625                 630                 635                 640 


Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser Arg 
                645                 650                 655     


Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala Arg 
            660                 665                 670         


His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro Pro 
        675                 680                 685             


Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg Gln 
    690                 695                 700                 


Ala Pro Lys Gln Gly Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro 
705                 710                 715                 720 


Ile Gln Arg Lys Gln Gly Ala Gly Ala Pro Thr Ala Pro 
                725                 730             


<210>  96
<211>  2202
<212>  DNA
<213>  Homo sapiens

<400>  96
atgcgcggcc tcgggctctg gctgctgggc gcgatgatgc tgcctgggcc tgcacccaga       60

gagggtgagc tacgtccttg gggccacagg gcacaacttc accctccacc tgcggaagaa      120

cagggacctg ctgggctccg gctacacaga gacctatacg gctgccaatg gctccgaggt      180

gacggagcag cctcgcgggc aggaccactg cttctaccag ggccacgtag aggggtaccc      240

ggactcagcc gccagcctca gcacctgtgc cggcctcagg tggggtcaga cctgcacctg      300

atcgagcccc tggatgaagg tggcgagggc ggacggcacg ccgtgtacca ggctgagcac      360

ctgctgcaga cggccgggac ctgcggggtc agcgacgaca gcctgggcag cctcctggga      420

ccccggacgg cagccgtctt caggcctcgg cccggggact ctctgccatc ccgagagacc      480

cgctacgtgg agctgtatgt ggtcgtggac aatgcagagt tccagatgct ggggagcgaa      540

gcagccgtgc gtcatcgggt gctggaggtg gtgaatcacg tggacaagct atatcagaaa      600

ctcaacttcc gtgtggtcct ggtgggcctg gagatttgga atagtcagga caggttccac      660

gtcagccccg accccagtgt cacactggag aacctcctga cctggcaggc acggcaacgg      720

acacggcggc acctgcatga caacgtacag ctcatcacgg gtgtcgactt caccgggact      780

accgtggggt ttgccagggt gtccgccatg tgctcccaca gctcaggggc tgtgaaccag      840

gaccacagca agaaccccgt gggcgtggcc tgtaccatgg cccatgagat gggccacaac      900

ctgggcatgg accatgatga gaacgtccag ggctgccgct gccaggaacg cttcgaggcc      960

ggccgctgca tcatggcggg cagcattggc tccagtttcc ccaggatgtt cagtgactgc     1020

agccaggcct acctggagag ctttttggag cggccgcagt cggtgtgcct cgccaacgcc     1080

cctgacctca gccacctggt gggcggcccc gtgtgtggga acctgtttgt ggagcgtggg     1140

gagcagtgcg actgcggccc ccccgaggac tgccggaacc gctgctgcaa ctctaccacc     1200

tgccagctgg ctgagggggc ccagtgtgcg cacggtacct gctgccagga gtgcaaggtg     1260

aagccggctg gtgagctgtg ccgtcccaag aaggacatgt gtgacctcga ggagttctgt     1320

gacggccggc accctgagtg cccggaagac gccttccagg agaacggcac gccctgctcc     1380

gggggctact gctacaacgg ggcctgtccc acactggccc agcagtgcca ggccttctgg     1440

gggccaggtg ggcaggctgc cgaggagtcc tgcttctcct atgacatcct accaggctgc     1500

aaggccagcc ggtacagggc tgacatgtgt ggcgttctgc agtgcaaggg tgggcagcag     1560

cccctggggc gtgccatctg catcgtggat gtgtgccacg cgctcaccac agaggatggc     1620

actgcgtatg aaccagtgcc cgagggcacc cggtgtggac cagagaaggt gtgcaaccac     1680

aagcaggagt gccactgcca cgcgggctgg gccccgcccc actgcgcgaa gctgctgact     1740

gaggtgcacg cagcgtccgg gagcctcccc gtcttcgtgg tggtggttct ggtgctcctg     1800

gcagttgtgc tggtcaccct ggcaggcatc atcgtctacc gcaaagcccg gagccgcatc     1860

ctgagcagga acgtggctcc caagaccaca atggggcgct ccaaccccct gttccaccag     1920

gctgccagcc gcgtgccggc caagggcggg gctccagccc catccagggg cccccaagag     1980

ctggtcccca ccacccaccc gggccagccc gcccgacacc cggcctcctc ggtggctctg     2040

aagaggccgc cccctgctcc tccggtcact gtgtccagcc cacccttccc agttcctgtc     2100

tacacccggc aggcaccaaa gcagggtgct gttggcccaa aggttgccct gaagcccccc     2160

atccagagga agcaaggagc cggagctccc acagcaccct ag                        2202


<210>  97
<211>  826
<212>  PRT
<213>  Mus sp.

<400>  97

Met Leu Gly Leu Trp Leu Leu Ser Val Leu Trp Thr Pro Ala Val Ala 
1               5                   10                  15      


Pro Gly Pro Pro Leu Pro His Val Lys Gln Tyr Glu Val Val Trp Pro 
            20                  25                  30          


Arg Arg Leu Ala Ala Ser Arg Ser Arg Arg Ala Leu Pro Ser His Trp 
        35                  40                  45              


Gly Gln Tyr Pro Glu Ser Leu Ser Tyr Ala Leu Gly Thr Ser Gly His 
    50                  55                  60                  


Val Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly Ser Ser 
65                  70                  75                  80  


Tyr Thr Glu Thr Tyr Ser Ala Ala Asn Gly Ser Glu Val Thr Glu Gln 
                85                  90                  95      


Leu Gln Glu Gln Asp His Cys Leu Tyr Gln Gly His Val Glu Gly Tyr 
            100                 105                 110         


Glu Gly Ser Ala Ala Ser Ile Ser Thr Cys Ala Gly Leu Arg Gly Phe 
        115                 120                 125             


Phe Arg Val Gly Ser Thr Val His Leu Ile Glu Pro Leu Asp Ala Asp 
    130                 135                 140                 


Glu Glu Gly Gln His Ala Met Tyr Gln Ala Lys His Leu Gln Gln Lys 
145                 150                 155                 160 


Ala Gly Thr Cys Gly Val Lys Asp Thr Asn Leu Asn Asp Leu Gly Pro 
                165                 170                 175     


Arg Ala Leu Glu Ile Tyr Arg Ala Gln Pro Arg Asn Trp Leu Ile Pro 
            180                 185                 190         


Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Ala Asp Ser Gln Glu 
        195                 200                 205             


Phe Gln Lys Leu Gly Ser Arg Glu Ala Val Arg Gln Arg Val Leu Glu 
    210                 215                 220                 


Val Val Asn His Val Asp Lys Leu Tyr Gln Glu Leu Ser Phe Arg Val 
225                 230                 235                 240 


Val Leu Val Gly Leu Glu Ile Trp Asn Lys Asp Lys Phe Tyr Ile Ser 
                245                 250                 255     


Arg Tyr Ala Asn Val Thr Leu Glu Asn Phe Leu Ser Trp Arg Glu Gln 
            260                 265                 270         


Asn Leu Gln Gly Gln His Pro His Asp Asn Val Gln Leu Ile Thr Gly 
        275                 280                 285             


Val Asp Phe Ile Gly Ser Thr Val Gly Leu Ala Lys Val Ser Ala Leu 
    290                 295                 300                 


Cys Ser Arg His Ser Gly Ala Val Asn Gln Asp His Ser Lys Asn Ser 
305                 310                 315                 320 


Ile Gly Val Ala Ser Thr Met Ala His Glu Leu Gly His Asn Leu Gly 
                325                 330                 335     


Met Ser His Asp Glu Asp Ile Pro Gly Cys Tyr Cys Pro Glu Pro Arg 
            340                 345                 350         


Glu Gly Gly Gly Cys Ile Met Thr Glu Ser Ile Gly Ser Lys Phe Pro 
        355                 360                 365             


Arg Ile Phe Ser Arg Cys Ser Lys Ile Asp Leu Glu Ser Phe Val Thr 
    370                 375                 380                 


Lys Pro Gln Thr Gly Cys Leu Thr Asn Val Pro Asp Val Asn Arg Phe 
385                 390                 395                 400 


Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val Glu His Gly Glu Gln 
                405                 410                 415     


Cys Asp Cys Gly Thr Pro Gln Asp Cys Gln Asn Pro Cys Cys Asn Ala 
            420                 425                 430         


Thr Thr Cys Gln Leu Val Lys Gly Ala Glu Cys Ala Ser Gly Thr Cys 
        435                 440                 445             


Cys His Glu Cys Lys Val Lys Pro Ala Gly Glu Val Cys Arg Leu Ser 
    450                 455                 460                 


Lys Asp Lys Cys Asp Leu Glu Glu Phe Cys Asp Gly Arg Lys Pro Thr 
465                 470                 475                 480 


Cys Pro Glu Asp Ala Phe Gln Gln Asn Gly Thr Pro Cys Pro Gly Gly 
                485                 490                 495     


Tyr Cys Phe Asp Gly Ser Cys Pro Thr Leu Ala Gln Gln Cys Arg Asp 
            500                 505                 510         


Leu Trp Gly Pro Gly Ala Arg Val Ala Ala Asp Ser Cys Tyr Thr Phe 
        515                 520                 525             


Ser Ile Pro Pro Gly Cys Asn Gly Arg Met Tyr Ser Gly Arg Ile Asn 
    530                 535                 540                 


Arg Cys Gly Ala Leu Tyr Cys Glu Gly Gly Gln Lys Pro Leu Glu Arg 
545                 550                 555                 560 


Ser Phe Cys Thr Phe Ser Ser Asn His Gly Val Cys His Ala Leu Gly 
                565                 570                 575     


Thr Gly Ser Asn Ile Asp Thr Phe Glu Leu Val Leu Gln Gly Thr Lys 
            580                 585                 590         


Cys Glu Glu Gly Lys Val Cys Met Asp Gly Ser Cys Gln Asp Leu Arg 
        595                 600                 605             


Val Tyr Arg Ser Glu Asn Cys Ser Ala Lys Cys Asn Asn His Gly Val 
    610                 615                 620                 


Cys Asn His Lys Arg Glu Cys His Cys His Lys Gly Trp Ala Pro Pro 
625                 630                 635                 640 


Asn Cys Val Gln Arg Leu Ala Asp Val Ser Asp Glu Gln Ala Ala Ser 
                645                 650                 655     


Thr Ser Leu Pro Val Ser Val Val Val Val Leu Val Ile Leu Val Ala 
            660                 665                 670         


Ala Met Val Ile Val Ala Gly Ile Val Ile Tyr Arg Lys Ala Pro Arg 
        675                 680                 685             


Gln Ile Gln Arg Arg Ser Val Ala Pro Lys Pro Ile Ser Gly Leu Ser 
    690                 695                 700                 


Asn Pro Leu Phe Tyr Thr Arg Asp Ser Ser Leu Pro Ala Lys Asn Arg 
705                 710                 715                 720 


Pro Pro Asp Pro Ser Glu Thr Val Ser Thr Asn Gln Pro Pro Arg Pro 
                725                 730                 735     


Ile Val Lys Pro Lys Arg Pro Pro Pro Ala Pro Pro Gly Ala Val Ser 
            740                 745                 750         


Ser Ser Pro Leu Pro Val Pro Val Tyr Ala Pro Lys Ile Pro Asn Gln 
        755                 760                 765             


Phe Arg Pro Asp Pro Pro Thr Lys Pro Leu Pro Glu Leu Lys Pro Lys 
    770                 775                 780                 


Gln Val Lys Pro Thr Phe Ala Pro Pro Thr Pro Pro Val Lys Pro Gly 
785                 790                 795                 800 


Thr Gly Gly Thr Val Pro Gly Ala Thr Gln Gly Ala Gly Glu Pro Lys 
                805                 810                 815     


Val Ala Leu Lys Val Pro Ile Gln Lys Arg 
            820                 825     


<210>  98
<211>  2481
<212>  DNA
<213>  Mus sp.

<400>  98
atgcttggcc tctggctgct cagcgtctta tggacaccag cagtagcccc tggacctcct       60

ttgccccatg tgaaacagta tgaagtggtt tggcctcggc gcctagctgc atcccgctcc      120

cgcagagccc tgccctccca ctggggccag tacccagaga gtctgagcta tgctcttggg      180

accagcgggc acgttttcac cctgcacctt cgaaagaaca gggacctgct gggctcaagc      240

tacacagaga cctactcagc tgccaatggc tctgaggtga cagagcaact gcaggagcag      300

gaccattgcc tctaccaagg ccatgtggaa gggtacgagg gctcagctgc cagtattagc      360

acctgtgctg gcctcagggg ctttttccga gttgggtcca ctgtccactt gattgagcct      420

ctggatgctg atgaagaggg gcaacatgcg atgtatcagg caaagcatct gcaacagaag      480

gctgggacct gtggggtcaa agataccaac ctgaatgacc tagggcctcg ggcattagaa      540

atatacaggg ctcagccacg gaactggctg atacccagag aaacccgcta tgtggagttg      600

tatgtggttg cagacagcca agagttccag aagttgggga gcagagaggc cgtgcgccag      660

cgagtgctgg aggttgtaaa ccacgtggac aagctttatc aggaactcag ttttcgagtt      720

gtcctggtgg gcctggagat ctggaacaag gacaaattct acatcagccg ctatgccaac      780

gtgacactgg agaacttctt gtcctggagg gaacagaact tgcaagggca gcacccacat      840

gacaacgtgc aacttatcac gggggttgat ttcattggga gcactgttgg actggctaag      900

gtgtctgccc tgtgttcccg tcactccgga gctgtgaatc aggaccactc caagaactcc      960

attggtgtag cctccaccat ggcccatgag ctgggccaca acctgggcat gagccatgat     1020

gaggacattc caggatgcta ctgtcctgaa ccacgggagg gtggtggctg catcatgacc     1080

gaaagcatcg gctccaagtt ccccaggata ttcagcaggt gtagcaagat tgacctagag     1140

tcattcgtga caaaacccca gacaggctgc ctgaccaatg ttccagatgt caaccggttc     1200

gtgggtggcc ctgtgtgtgg aaacctgttt gtggagcatg gagagcagtg tgactgtggc     1260

acacctcagg actgtcaaaa cccctgctgc aatgccacca cttgccagct ggtcaagggg     1320

gcagagtgtg ccagtggtac ctgttgtcat gaatgcaagg tgaagccagc tggagaggtg     1380

tgtcgtctca gtaaggacaa atgtgacctg gaggagttct gtgatggccg gaagccaaca     1440

tgtcccgaag atgccttcca acagaatggc actccctgcc cagggggcta ctgctttgat     1500

gggagctgtc ccaccctggc acagcagtgc cgggatctgt gggggccagg tgctcgggta     1560

gcagccgact cctgctatac ctttagcatc cctccgggct gcaatgggag gatgtactct     1620

ggcaggatca accggtgtgg agcgctgtac tgtgagggag gccagaagcc ccttgaacgc     1680

tccttctgca ctttctcctc caaccatgga gtctgccatg ctcttggcac aggcagcaac     1740

attgacacct ttgagctggt attgcagggc accaagtgcg aggagggaaa ggtttgcatg     1800

gatggaagct gccaggacct ccgtgtatac agatctgaaa actgctctgc taaatgcaac     1860

aaccatgggg tatgcaacca caagagggag tgccactgtc acaagggctg ggcaccaccc     1920

aactgtgtac agcggctggc agatgtatca gatgaacaag cagcgtctac gagcctccca     1980

gtcagtgtgg ttgtggtctt ggtgatcctg gtggctgcga tggtcatcgt ggcaggcatc     2040

gtcatctacc gaaaggctcc gagacaaatc cagaggagga gtgtggcacc caagcctatc     2100

tcggggctct ccaaccccct attctacaca agggacagca gcctgccagc taagaacagg     2160

cctccagacc cttctgagac agtttctacc aaccagcccc caagacccat agtgaaacca     2220

aagaggcctc cccctgcacc tccaggtgct gtgtccagtt caccactccc agttcctgtt     2280

tatgccccaa agataccaaa tcagtttaga cctgatcctc ccaccaagcc cctcccagag     2340

ctgaaaccca agcaggtcaa gccaaccttt gcacccccga caccaccagt caagcccggg     2400

actggaggga cggtgcctgg agcaactcag ggagctggtg agccaaaggt tgctctgaag     2460

gtccccatcc agaagaggtg a                                               2481


<210>  99
<211>  825
<212>  PRT
<213>  Mus sp.

<400>  99

Met Leu Gly Leu Trp Leu Leu Ser Val Leu Trp Thr Pro Val Ala Pro 
1               5                   10                  15      


Gly Pro Pro Leu Pro His Val Lys Gln Tyr Glu Val Val Trp Pro Arg 
            20                  25                  30          


Arg Leu Ala Ala Ser Arg Ser Arg Arg Ala Leu Pro Ser His Trp Gly 
        35                  40                  45              


Gln Tyr Pro Glu Ser Leu Ser Tyr Ala Leu Gly Thr Ser Gly His Val 
    50                  55                  60                  


Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly Ser Ser Tyr 
65                  70                  75                  80  


Thr Glu Thr Tyr Ser Ala Ala Asn Gly Ser Glu Val Thr Glu Gln Leu 
                85                  90                  95      


Gln Glu Gln Asp His Cys Leu Tyr Gln Gly His Val Glu Gly Tyr Glu 
            100                 105                 110         


Gly Ser Ala Ala Ser Ile Ser Thr Cys Ala Gly Leu Arg Gly Phe Phe 
        115                 120                 125             


Arg Val Gly Ser Thr Val His Leu Ile Glu Pro Leu Asp Ala Asp Glu 
    130                 135                 140                 


Glu Gly Gln His Ala Met Tyr Gln Ala Lys His Leu Gln Gln Lys Ala 
145                 150                 155                 160 


Gly Thr Cys Gly Val Lys Asp Thr Asn Leu Asn Asp Leu Gly Pro Arg 
                165                 170                 175     


Ala Leu Glu Ile Tyr Arg Ala Gln Pro Arg Asn Trp Leu Ile Pro Arg 
            180                 185                 190         


Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Ala Asp Ser Gln Glu Phe 
        195                 200                 205             


Gln Lys Leu Gly Ser Arg Glu Ala Val Arg Gln Arg Val Leu Glu Val 
    210                 215                 220                 


Val Asn His Val Asp Lys Leu Tyr Gln Glu Leu Ser Phe Arg Val Val 
225                 230                 235                 240 


Leu Val Gly Leu Glu Ile Trp Asn Lys Asp Lys Phe Tyr Ile Ser Arg 
                245                 250                 255     


Tyr Ala Asn Val Thr Leu Glu Asn Phe Leu Ser Trp Arg Glu Gln Asn 
            260                 265                 270         


Leu Gln Gly Gln His Pro His Asp Asn Val Gln Leu Ile Thr Gly Val 
        275                 280                 285             


Asp Phe Ile Gly Ser Thr Val Gly Leu Ala Lys Val Ser Ala Leu Cys 
    290                 295                 300                 


Ser Arg His Ser Gly Ala Val Asn Gln Asp His Ser Lys Asn Ser Ile 
305                 310                 315                 320 


Gly Val Ala Ser Thr Met Ala His Glu Leu Gly His Asn Leu Gly Met 
                325                 330                 335     


Ser His Asp Glu Asp Ile Pro Gly Cys Tyr Cys Pro Glu Pro Arg Glu 
            340                 345                 350         


Gly Gly Gly Cys Ile Met Thr Glu Ser Ile Gly Ser Lys Phe Pro Arg 
        355                 360                 365             


Ile Phe Ser Arg Cys Ser Lys Ile Asp Leu Glu Ser Phe Val Thr Lys 
    370                 375                 380                 


Pro Gln Thr Gly Cys Leu Thr Asn Val Pro Asp Val Asn Arg Phe Val 
385                 390                 395                 400 


Gly Gly Pro Val Cys Gly Asn Leu Phe Val Glu His Gly Glu Gln Cys 
                405                 410                 415     


Asp Cys Gly Thr Pro Gln Asp Cys Gln Asn Pro Cys Cys Asn Ala Thr 
            420                 425                 430         


Thr Cys Gln Leu Val Lys Gly Ala Glu Cys Ala Ser Gly Thr Cys Cys 
        435                 440                 445             


His Glu Cys Lys Val Lys Pro Ala Gly Glu Val Cys Arg Leu Ser Lys 
    450                 455                 460                 


Asp Lys Cys Asp Leu Glu Glu Phe Cys Asp Gly Arg Lys Pro Thr Cys 
465                 470                 475                 480 


Pro Glu Asp Ala Phe Gln Gln Asn Gly Thr Pro Cys Pro Gly Gly Tyr 
                485                 490                 495     


Cys Phe Asp Gly Ser Cys Pro Thr Leu Ala Gln Gln Cys Arg Asp Leu 
            500                 505                 510         


Trp Gly Pro Gly Ala Arg Val Ala Ala Asp Ser Cys Tyr Thr Phe Ser 
        515                 520                 525             


Ile Pro Pro Gly Cys Asn Gly Arg Met Tyr Ser Gly Arg Ile Asn Arg 
    530                 535                 540                 


Cys Gly Ala Leu Tyr Cys Glu Gly Gly Gln Lys Pro Leu Glu Arg Ser 
545                 550                 555                 560 


Phe Cys Thr Phe Ser Ser Asn His Gly Val Cys His Ala Leu Gly Thr 
                565                 570                 575     


Gly Ser Asn Ile Asp Thr Phe Glu Leu Val Leu Gln Gly Thr Lys Cys 
            580                 585                 590         


Glu Glu Gly Lys Val Cys Met Asp Gly Ser Cys Gln Asp Leu Arg Val 
        595                 600                 605             


Tyr Arg Ser Glu Asn Cys Ser Ala Lys Cys Asn Asn His Gly Val Cys 
    610                 615                 620                 


Asn His Lys Arg Glu Cys His Cys His Lys Gly Trp Ala Pro Pro Asn 
625                 630                 635                 640 


Cys Val Gln Arg Leu Ala Asp Val Ser Asp Glu Gln Ala Ala Ser Thr 
                645                 650                 655     


Ser Leu Pro Val Ser Val Val Val Val Leu Val Ile Leu Val Ala Ala 
            660                 665                 670         


Met Val Ile Val Ala Gly Ile Val Ile Tyr Arg Lys Ala Pro Arg Gln 
        675                 680                 685             


Ile Gln Arg Arg Ser Val Ala Pro Lys Pro Ile Ser Gly Leu Ser Asn 
    690                 695                 700                 


Pro Leu Phe Tyr Thr Arg Asp Ser Ser Leu Pro Ala Lys Asn Arg Pro 
705                 710                 715                 720 


Pro Asp Pro Ser Glu Thr Val Ser Thr Asn Gln Pro Pro Arg Pro Ile 
                725                 730                 735     


Val Lys Pro Lys Arg Pro Pro Pro Ala Pro Pro Gly Ala Val Ser Ser 
            740                 745                 750         


Ser Pro Leu Pro Val Pro Val Tyr Ala Pro Lys Ile Pro Asn Gln Phe 
        755                 760                 765             


Arg Pro Asp Pro Pro Thr Lys Pro Leu Pro Glu Leu Lys Pro Lys Gln 
    770                 775                 780                 


Val Lys Pro Thr Phe Ala Pro Pro Thr Pro Pro Val Lys Pro Gly Thr 
785                 790                 795                 800 


Gly Gly Thr Val Pro Gly Ala Thr Gln Gly Ala Gly Glu Pro Lys Val 
                805                 810                 815     


Ala Leu Lys Val Pro Ile Gln Lys Arg 
            820                 825 


<210>  100
<211>  2478
<212>  DNA
<213>  Mus sp.

<400>  100
atgcttggcc tctggctgct cagcgtctta tggacaccag tagcccctgg acctcctttg       60

ccccatgtga aacagtatga agtggtttgg cctcggcgcc tagctgcatc ccgctcccgc      120

agagccctgc cctcccactg gggccagtac ccagagagtc tgagctatgc tcttgggacc      180

agcgggcacg ttttcaccct gcaccttcga aagaacaggg acctgctggg ctcaagctac      240

acagagacct actcagctgc caatggctct gaggtgacag agcaactgca ggagcaggac      300

cattgcctct accaaggcca tgtggaaggg tacgagggct cagctgccag tattagcacc      360

tgtgctggcc tcaggggctt tttccgagtt gggtccactg tccacttgat tgagcctctg      420

gatgctgatg aagaggggca acatgcgatg tatcaggcaa agcatctgca acagaaggct      480

gggacctgtg gggtcaaaga taccaacctg aatgacctag ggcctcgggc attagaaata      540

tacagggctc agccacggaa ctggctgata cccagagaaa cccgctatgt ggagttgtat      600

gtggttgcag acagccaaga gttccagaag ttggggagca gagaggccgt gcgccagcga      660

gtgctggagg ttgtaaacca cgtggacaag ctttatcagg aactcagttt tcgagttgtc      720

ctggtgggcc tggagatctg gaacaaggac aaattctaca tcagccgcta tgccaacgtg      780

acactggaga acttcttgtc ctggagggaa cagaacttgc aagggcagca cccacatgac      840

aacgtgcaac ttatcacggg ggttgatttc attgggagca ctgttggact ggctaaggtg      900

tctgccctgt gttcccgtca ctccggagct gtgaatcagg accactccaa gaactccatt      960

ggtgtagcct ccaccatggc ccatgagctg ggccacaacc tgggcatgag ccatgatgag     1020

gacattccag gatgctactg tcctgaacca cgggagggtg gtggctgcat catgaccgaa     1080

agcatcggct ccaagttccc caggatattc agcaggtgta gcaagattga cctagagtca     1140

ttcgtgacaa aaccccagac aggctgcctg accaatgttc cagatgtcaa ccggttcgtg     1200

ggtggccctg tgtgtggaaa cctgtttgtg gagcatggag agcagtgtga ctgtggcaca     1260

cctcaggact gtcaaaaccc ctgctgcaat gccaccactt gccagctggt caagggggca     1320

gagtgtgcca gtggtacctg ttgtcatgaa tgcaaggtga agccagctgg agaggtgtgt     1380

cgtctcagta aggacaaatg tgacctggag gagttctgtg atggccggaa gccaacatgt     1440

cccgaagatg ccttccaaca gaatggcact ccctgcccag ggggctactg ctttgatggg     1500

agctgtccca ccctggcaca gcagtgccgg gatctgtggg ggccaggtgc tcgggtagca     1560

gccgactcct gctatacctt tagcatccct ccgggctgca atgggaggat gtactctggc     1620

aggatcaacc ggtgtggagc gctgtactgt gagggaggcc agaagcccct tgaacgctcc     1680

ttctgcactt tctcctccaa ccatggagtc tgccatgctc ttggcacagg cagcaacatt     1740

gacacctttg agctggtatt gcagggcacc aagtgcgagg agggaaaggt ttgcatggat     1800

ggaagctgcc aggacctccg tgtatacaga tctgaaaact gctctgctaa atgcaacaac     1860

catggggtat gcaaccacaa gagggagtgc cactgtcaca agggctgggc accacccaac     1920

tgtgtacagc ggctggcaga tgtatcagat gaacaagcag cgtctacgag cctcccagtc     1980

agtgtggttg tggtcttggt gatcctggtg gctgcgatgg tcatcgtggc aggcatcgtc     2040

atctaccgaa aggctccgag acaaatccag aggaggagtg tggcacccaa gcctatctcg     2100

gggctctcca accccctatt ctacacaagg gacagcagcc tgccagctaa gaacaggcct     2160

ccagaccctt ctgagacagt ttctaccaac cagcccccaa gacccatagt gaaaccaaag     2220

aggcctcccc ctgcacctcc aggtgctgtg tccagttcac cactcccagt tcctgtttat     2280

gccccaaaga taccaaatca gtttagacct gatcctccca ccaagcccct cccagagctg     2340

aaacccaagc aggtcaagcc aacctttgca cccccgacac caccagtcaa gcccgggact     2400

ggagggacgg tgcctggagc aactcaggga gctggtgagc caaaggttgc tctgaaggtc     2460

cccatccaga agaggtga                                                   2478


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  101
cggcacctgc atgacaacgt a                                                 21


<210>  102
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  102
ctgcgcgaag ctgctgactg a                                                 21


<210>  103
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  103

Cys Asp Leu Glu Glu Phe Cys Asp Gly Arg His Pro Glu Cys Pro Glu 
1               5                   10                  15      


Asp 
    


<210>  104
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  104

Arg Asn Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala 
1               5                   10                  15      


Gln Cys Ala His Gly Thr Cys Cys Gln Glu Cys Lys 
            20                  25              


