                         SEQUENCE LISTING

<110>  The University of Sydney
 
<120>  Anti-inflammatory agents

<130>  53079781CEW

<150>  AU2019901968
<151>  2019-06-06

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Val Leu Thr Val Val 
1               5       


<210>  2
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10      


<210>  3
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val 
            20      


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Lys Lys Lys Thr Val Leu Thr Val Val 
1               5                   10  


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Lys Lys Lys Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10                  15  


<210>  6
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Lys Lys Lys Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Val Leu Thr Val Val 
            20                  25  


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  polyethylene glycol (PEG)

<400>  7

Xaa Thr Val Leu Thr Val Val 
1               5           


<210>  8
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  polyethylene glycol (PEG)

<400>  8

Xaa Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10          


<210>  9
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  polyethylene glycol (PEG)

<400>  9

Xaa Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Leu Thr Val Val 
            20          


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  polyethylene glycol (PEG)

<400>  10

Lys Lys Lys Lys Xaa Thr Val Leu Thr Val Val 
1               5                   10      


<210>  11
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  polyethylene glycol (PEG)

<400>  11

Lys Lys Lys Lys Xaa Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10                  15      


<210>  12
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  polyethylene glycol (PEG)

<400>  12

Lys Lys Lys Lys Xaa Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Val Leu Thr Val Val 
            20                  25      


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<400>  13

Xaa Thr Val Leu Thr Val Val 
1               5           


<210>  14
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<400>  14

Xaa Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10          


<210>  15
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<400>  15

Xaa Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Leu Thr Val Val 
            20          


<210>  16
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  polyethylene glycol (PEG)

<400>  16

Xaa Xaa Thr Val Leu Thr Val 
1               5           


<210>  17
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  polyethylene glycol (PEG)

<400>  17

Xaa Xaa Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10              


<210>  18
<211>  23
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  polyethylene glycol (PEG)

<400>  18

Xaa Xaa Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu 
1               5                   10                  15      


Leu Thr Val Leu Thr Val Val 
            20              


<210>  19
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  polyethylene glycol (PEG)

<400>  19

Xaa Xaa Thr Val Leu Thr Val Val 
1               5               


<210>  20
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  polyethylene glycol (PEG)

<400>  20

Xaa Lys Lys Lys Lys Xaa Leu Leu Leu Leu Leu Thr Val Leu Thr Val 
1               5                   10                  15      


Val 
    


<210>  21
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  polyethylene glycol (PEG)

<400>  21

Xaa Lys Lys Lys Lys Xaa Met Thr Pro Gly Thr Gln Ser Pro Phe Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
            20                  25          


<210>  22
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  22

Lys Lys Lys Lys Gly Gly Gly Met Thr Pro Gly Thr Gln Ser Pro Phe 
1               5                   10                  15      


Phe Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
            20                  25              


<210>  23
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  23

Lys Lys Lys Lys Gly Gly Gly Thr Pro Gly Thr Gln Ser Pro Phe Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
            20                  25          


<210>  24
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  24

Arg Arg Arg Arg Thr Val Leu Thr Val Val 
1               5                   10  


<210>  25
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Arg Arg Arg Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10                  15  


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

His His His His Thr Val Leu Thr Val Val 
1               5                   10  


<210>  27
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  27

His His His His Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10                  15  


<210>  28
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  28

Asn Asn Asn Asn Thr Val Leu Thr Val Val 
1               5                   10  


<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  29

Asn Asn Asn Asn Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10                  15  


<210>  30
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  30

Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr Val 
1               5                   10                  15      


Leu Thr Val Val 
            20  


<210>  31
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Lys Lys Lys Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Val Leu Thr Val Val 
            20                  


<210>  32
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  (Gd)DOTA - metal label

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  polyethylene glycol (PEG)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  photoleucine

<400>  32

Xaa Lys Lys Lys Lys Xaa Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Val Leu Thr Val Val 
            20                  25      


<210>  33
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  (Gd)DOTA - metal label

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  polyethylene glycol (PEG)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  photoleucine

<400>  33

Xaa Lys Lys Lys Lys Xaa Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Val Leu Thr Val Val 
            20                  25      


<210>  34
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  biotin tag

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  polyethylene glycol (PEG)

<400>  34

Xaa Lys Lys Lys Lys Xaa Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Val Leu Thr Val Val 
            20                  25      


<210>  35
<211>  26
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  biotin tag

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  polyethylene glycol (PEG)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  photoleucine

<400>  35

Xaa Lys Lys Lys Lys Xaa Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Val Leu Thr Val Val 
            20                  25      


<210>  36
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  36

Lys Lys Lys Lys Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu 
1               5                   10                  15      


Leu Thr Val Leu Thr Val Val 
            20              


<210>  37
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  37

Lys Lys Lys Lys Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Leu Thr Val Val 
            20          


<210>  38
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  38

Lys Lys Lys Lys Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val 
            20      


<210>  39
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  39

Lys Lys Lys Lys Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr Val 
1               5                   10                  15      


Leu Thr Val Val 
            20  


<210>  40
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  40

Lys Lys Lys Lys Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr Val Leu 
1               5                   10                  15      


Thr Val Val 
            


<210>  41
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  41

Lys Lys Lys Lys Pro Phe Phe Leu Leu Leu Leu Leu Thr Val Leu Thr 
1               5                   10                  15      


Val Val 
        


<210>  42
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  42

Lys Lys Lys Lys Phe Phe Leu Leu Leu Leu Leu Thr Val Leu Thr Val 
1               5                   10                  15      


Val 
    


<210>  43
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  43

Lys Lys Lys Lys Phe Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10                  15      


<210>  44
<211>  1259
<212>  PRT
<213>  Homo sapiens

<400>  44

Lys Lys Lys Lys Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu 
1               5                   10                  15      


Leu Leu Leu Thr Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser 
            20                  25                  30          


Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser 
        35                  40                  45              


Val Pro Ser Ser Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val 
    50                  55                  60                  


Leu Ser Ser His Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln 
65                  70                  75                  80  


Asp Val Thr Leu Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala 
                85                  90                  95      


Thr Trp Gly Gln Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu 
            100                 105                 110         


Gly Ser Thr Thr Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn 
        115                 120                 125             


Lys Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    130                 135                 140                 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
145                 150                 155                 160 


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
                165                 170                 175     


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
            180                 185                 190         


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
        195                 200                 205             


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    210                 215                 220                 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
225                 230                 235                 240 


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
                245                 250                 255     


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
            260                 265                 270         


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
        275                 280                 285             


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    290                 295                 300                 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
305                 310                 315                 320 


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
                325                 330                 335     


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
            340                 345                 350         


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
        355                 360                 365             


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    370                 375                 380                 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
385                 390                 395                 400 


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
                405                 410                 415     


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
            420                 425                 430         


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
        435                 440                 445             


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    450                 455                 460                 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
465                 470                 475                 480 


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
                485                 490                 495     


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
            500                 505                 510         


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
        515                 520                 525             


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    530                 535                 540                 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
545                 550                 555                 560 


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
                565                 570                 575     


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
            580                 585                 590         


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
        595                 600                 605             


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    610                 615                 620                 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
625                 630                 635                 640 


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
                645                 650                 655     


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
            660                 665                 670         


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
        675                 680                 685             


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    690                 695                 700                 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
705                 710                 715                 720 


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
                725                 730                 735     


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
            740                 745                 750         


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
        755                 760                 765             


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    770                 775                 780                 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
785                 790                 795                 800 


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
                805                 810                 815     


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
            820                 825                 830         


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
        835                 840                 845             


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    850                 855                 860                 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
865                 870                 875                 880 


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
                885                 890                 895     


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
            900                 905                 910         


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
        915                 920                 925             


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
    930                 935                 940                 


Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His 
945                 950                 955                 960 


Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu 
                965                 970                 975     


Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys 
            980                 985                 990         


Ser Thr Pro Phe Ser Ile Pro Ser  His His Ser Asp Thr  Pro Thr Thr 
        995                 1000                 1005             


Leu Ala  Ser His Ser Thr Lys  Thr Asp Ala Ser Ser  Thr His His 
    1010                 1015                 1020             


Ser Ser  Val Pro Pro Leu Thr  Ser Ser Asn His Ser  Thr Ser Pro 
    1025                 1030                 1035             


Gln Leu  Ser Thr Gly Val Ser  Phe Phe Phe Leu Ser  Phe His Ile 
    1040                 1045                 1050             


Ser Asn  Leu Gln Phe Asn Ser  Ser Leu Glu Asp Pro  Ser Thr Asp 
    1055                 1060                 1065             


Tyr Tyr  Gln Glu Leu Gln Arg  Asp Ile Ser Glu Met  Phe Leu Gln 
    1070                 1075                 1080             


Ile Tyr  Lys Gln Gly Gly Phe  Leu Gly Leu Ser Asn  Ile Lys Phe 
    1085                 1090                 1095             


Arg Pro  Gly Ser Val Val Val  Gln Leu Thr Leu Ala  Phe Arg Glu 
    1100                 1105                 1110             


Gly Thr  Ile Asn Val His Asp  Val Glu Thr Gln Phe  Asn Gln Tyr 
    1115                 1120                 1125             


Lys Thr  Glu Ala Ala Ser Arg  Tyr Asn Leu Thr Ile  Ser Asp Val 
    1130                 1135                 1140             


Ser Val  Ser Asp Val Pro Phe  Pro Phe Ser Ala Gln  Ser Gly Ala 
    1145                 1150                 1155             


Gly Val  Pro Gly Trp Gly Ile  Ala Leu Leu Val Leu  Val Cys Val 
    1160                 1165                 1170             


Leu Val  Ala Leu Ala Ile Val  Tyr Leu Ile Ala Leu  Ala Val Cys 
    1175                 1180                 1185             


Gln Cys  Arg Arg Lys Asn Tyr  Gly Gln Leu Asp Ile  Phe Pro Ala 
    1190                 1195                 1200             


Arg Asp  Thr Tyr His Pro Met  Ser Glu Tyr Pro Thr  Tyr His Thr 
    1205                 1210                 1215             


His Gly  Arg Tyr Val Pro Pro  Ser Ser Thr Asp Arg  Ser Pro Tyr 
    1220                 1225                 1230             


Glu Lys  Val Ser Ala Gly Asn  Gly Gly Ser Ser Leu  Ser Tyr Thr 
    1235                 1240                 1245             


Asn Pro  Ala Val Ala Ala Thr  Ser Ala Asn Leu 
    1250                 1255                 


<210>  45
<211>  1256
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  polyethylene glycol (PEG)

<400>  45

Xaa Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro 
            20                  25                  30          


Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser 
        35                  40                  45              


Ser Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser 
    50                  55                  60                  


His Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr 
65                  70                  75                  80  


Leu Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly 
                85                  90                  95      


Gln Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr 
            100                 105                 110         


Thr Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala 
        115                 120                 125             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    130                 135                 140                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
145                 150                 155                 160 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                165                 170                 175     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            180                 185                 190         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        195                 200                 205             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    210                 215                 220                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
225                 230                 235                 240 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                245                 250                 255     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            260                 265                 270         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        275                 280                 285             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    290                 295                 300                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
305                 310                 315                 320 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                325                 330                 335     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            340                 345                 350         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        355                 360                 365             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    370                 375                 380                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
385                 390                 395                 400 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                405                 410                 415     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            420                 425                 430         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        435                 440                 445             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    450                 455                 460                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
465                 470                 475                 480 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                485                 490                 495     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            500                 505                 510         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        515                 520                 525             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    530                 535                 540                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
545                 550                 555                 560 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                565                 570                 575     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            580                 585                 590         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        595                 600                 605             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    610                 615                 620                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
625                 630                 635                 640 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                645                 650                 655     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            660                 665                 670         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        675                 680                 685             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    690                 695                 700                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
705                 710                 715                 720 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                725                 730                 735     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            740                 745                 750         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        755                 760                 765             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    770                 775                 780                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
785                 790                 795                 800 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                805                 810                 815     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            820                 825                 830         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        835                 840                 845             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    850                 855                 860                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
865                 870                 875                 880 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                885                 890                 895     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            900                 905                 910         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        915                 920                 925             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    930                 935                 940                 


Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr 
945                 950                 955                 960 


Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn 
                965                 970                 975     


Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro 
            980                 985                 990         


Phe Ser Ile Pro Ser His His Ser  Asp Thr Pro Thr Thr  Leu Ala Ser 
        995                 1000                 1005             


His Ser  Thr Lys Thr Asp Ala  Ser Ser Thr His His  Ser Ser Val 
    1010                 1015                 1020             


Pro Pro  Leu Thr Ser Ser Asn  His Ser Thr Ser Pro  Gln Leu Ser 
    1025                 1030                 1035             


Thr Gly  Val Ser Phe Phe Phe  Leu Ser Phe His Ile  Ser Asn Leu 
    1040                 1045                 1050             


Gln Phe  Asn Ser Ser Leu Glu  Asp Pro Ser Thr Asp  Tyr Tyr Gln 
    1055                 1060                 1065             


Glu Leu  Gln Arg Asp Ile Ser  Glu Met Phe Leu Gln  Ile Tyr Lys 
    1070                 1075                 1080             


Gln Gly  Gly Phe Leu Gly Leu  Ser Asn Ile Lys Phe  Arg Pro Gly 
    1085                 1090                 1095             


Ser Val  Val Val Gln Leu Thr  Leu Ala Phe Arg Glu  Gly Thr Ile 
    1100                 1105                 1110             


Asn Val  His Asp Val Glu Thr  Gln Phe Asn Gln Tyr  Lys Thr Glu 
    1115                 1120                 1125             


Ala Ala  Ser Arg Tyr Asn Leu  Thr Ile Ser Asp Val  Ser Val Ser 
    1130                 1135                 1140             


Asp Val  Pro Phe Pro Phe Ser  Ala Gln Ser Gly Ala  Gly Val Pro 
    1145                 1150                 1155             


Gly Trp  Gly Ile Ala Leu Leu  Val Leu Val Cys Val  Leu Val Ala 
    1160                 1165                 1170             


Leu Ala  Ile Val Tyr Leu Ile  Ala Leu Ala Val Cys  Gln Cys Arg 
    1175                 1180                 1185             


Arg Lys  Asn Tyr Gly Gln Leu  Asp Ile Phe Pro Ala  Arg Asp Thr 
    1190                 1195                 1200             


Tyr His  Pro Met Ser Glu Tyr  Pro Thr Tyr His Thr  His Gly Arg 
    1205                 1210                 1215             


Tyr Val  Pro Pro Ser Ser Thr  Asp Arg Ser Pro Tyr  Glu Lys Val 
    1220                 1225                 1230             


Ser Ala  Gly Asn Gly Gly Ser  Ser Leu Ser Tyr Thr  Asn Pro Ala 
    1235                 1240                 1245             


Val Ala  Ala Thr Ser Ala Asn  Leu 
    1250                 1255     


<210>  46
<211>  1260
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  polyethylene glycol (PEG)

<400>  46

Lys Lys Lys Lys Xaa Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu 
1               5                   10                  15      


Leu Leu Leu Leu Thr Val Leu Thr Val Val Thr Gly Ser Gly His Ala 
            20                  25                  30          


Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser 
        35                  40                  45              


Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser 
    50                  55                  60                  


Val Leu Ser Ser His Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly 
65                  70                  75                  80  


Gln Asp Val Thr Leu Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala 
                85                  90                  95      


Ala Thr Trp Gly Gln Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala 
            100                 105                 110         


Leu Gly Ser Thr Thr Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp 
        115                 120                 125             


Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    130                 135                 140                 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
145                 150                 155                 160 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
                165                 170                 175     


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
            180                 185                 190         


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
        195                 200                 205             


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    210                 215                 220                 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
225                 230                 235                 240 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
                245                 250                 255     


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
            260                 265                 270         


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
        275                 280                 285             


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    290                 295                 300                 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
305                 310                 315                 320 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
                325                 330                 335     


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
            340                 345                 350         


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
        355                 360                 365             


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    370                 375                 380                 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
385                 390                 395                 400 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
                405                 410                 415     


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
            420                 425                 430         


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
        435                 440                 445             


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    450                 455                 460                 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
465                 470                 475                 480 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
                485                 490                 495     


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
            500                 505                 510         


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
        515                 520                 525             


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    530                 535                 540                 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
545                 550                 555                 560 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
                565                 570                 575     


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
            580                 585                 590         


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
        595                 600                 605             


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    610                 615                 620                 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
625                 630                 635                 640 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
                645                 650                 655     


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
            660                 665                 670         


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
        675                 680                 685             


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    690                 695                 700                 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
705                 710                 715                 720 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
                725                 730                 735     


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
            740                 745                 750         


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
        755                 760                 765             


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    770                 775                 780                 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
785                 790                 795                 800 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
                805                 810                 815     


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
            820                 825                 830         


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
        835                 840                 845             


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    850                 855                 860                 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
865                 870                 875                 880 


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
                885                 890                 895     


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
            900                 905                 910         


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
        915                 920                 925             


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
    930                 935                 940                 


Ser Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val 
945                 950                 955                 960 


His Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr 
                965                 970                 975     


Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser 
            980                 985                 990         


Lys Ser Thr Pro Phe Ser Ile Pro  Ser His His Ser Asp  Thr Pro Thr 
        995                 1000                 1005             


Thr Leu  Ala Ser His Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His 
    1010                 1015                 1020             


His Ser  Ser Val Pro Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser 
    1025                 1030                 1035             


Pro Gln  Leu Ser Thr Gly Val  Ser Phe Phe Phe Leu  Ser Phe His 
    1040                 1045                 1050             


Ile Ser  Asn Leu Gln Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr 
    1055                 1060                 1065             


Asp Tyr  Tyr Gln Glu Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu 
    1070                 1075                 1080             


Gln Ile  Tyr Lys Gln Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys 
    1085                 1090                 1095             


Phe Arg  Pro Gly Ser Val Val  Val Gln Leu Thr Leu  Ala Phe Arg 
    1100                 1105                 1110             


Glu Gly  Thr Ile Asn Val His  Asp Val Glu Thr Gln  Phe Asn Gln 
    1115                 1120                 1125             


Tyr Lys  Thr Glu Ala Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp 
    1130                 1135                 1140             


Val Ser  Val Ser Asp Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly 
    1145                 1150                 1155             


Ala Gly  Val Pro Gly Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys 
    1160                 1165                 1170             


Val Leu  Val Ala Leu Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val 
    1175                 1180                 1185             


Cys Gln  Cys Arg Arg Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro 
    1190                 1195                 1200             


Ala Arg  Asp Thr Tyr His Pro  Met Ser Glu Tyr Pro  Thr Tyr His 
    1205                 1210                 1215             


Thr His  Gly Arg Tyr Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro 
    1220                 1225                 1230             


Tyr Glu  Lys Val Ser Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr 
    1235                 1240                 1245             


Thr Asn  Pro Ala Val Ala Ala  Thr Ser Ala Asn Leu  
    1250                 1255                 1260 


<210>  47
<211>  1256
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<400>  47

Xaa Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Thr Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro 
            20                  25                  30          


Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser 
        35                  40                  45              


Ser Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser 
    50                  55                  60                  


His Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr 
65                  70                  75                  80  


Leu Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly 
                85                  90                  95      


Gln Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr 
            100                 105                 110         


Thr Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala 
        115                 120                 125             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    130                 135                 140                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
145                 150                 155                 160 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                165                 170                 175     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            180                 185                 190         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        195                 200                 205             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    210                 215                 220                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
225                 230                 235                 240 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                245                 250                 255     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            260                 265                 270         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        275                 280                 285             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    290                 295                 300                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
305                 310                 315                 320 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                325                 330                 335     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            340                 345                 350         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        355                 360                 365             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    370                 375                 380                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
385                 390                 395                 400 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                405                 410                 415     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            420                 425                 430         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        435                 440                 445             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    450                 455                 460                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
465                 470                 475                 480 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                485                 490                 495     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            500                 505                 510         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        515                 520                 525             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    530                 535                 540                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
545                 550                 555                 560 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                565                 570                 575     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            580                 585                 590         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        595                 600                 605             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    610                 615                 620                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
625                 630                 635                 640 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                645                 650                 655     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            660                 665                 670         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        675                 680                 685             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    690                 695                 700                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
705                 710                 715                 720 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                725                 730                 735     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            740                 745                 750         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        755                 760                 765             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    770                 775                 780                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
785                 790                 795                 800 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                805                 810                 815     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            820                 825                 830         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        835                 840                 845             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    850                 855                 860                 


Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
865                 870                 875                 880 


Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala 
                885                 890                 895     


His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr 
            900                 905                 910         


Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala 
        915                 920                 925             


Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp 
    930                 935                 940                 


Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr 
945                 950                 955                 960 


Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn 
                965                 970                 975     


Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro 
            980                 985                 990         


Phe Ser Ile Pro Ser His His Ser  Asp Thr Pro Thr Thr  Leu Ala Ser 
        995                 1000                 1005             


His Ser  Thr Lys Thr Asp Ala  Ser Ser Thr His His  Ser Ser Val 
    1010                 1015                 1020             


Pro Pro  Leu Thr Ser Ser Asn  His Ser Thr Ser Pro  Gln Leu Ser 
    1025                 1030                 1035             


Thr Gly  Val Ser Phe Phe Phe  Leu Ser Phe His Ile  Ser Asn Leu 
    1040                 1045                 1050             


Gln Phe  Asn Ser Ser Leu Glu  Asp Pro Ser Thr Asp  Tyr Tyr Gln 
    1055                 1060                 1065             


Glu Leu  Gln Arg Asp Ile Ser  Glu Met Phe Leu Gln  Ile Tyr Lys 
    1070                 1075                 1080             


Gln Gly  Gly Phe Leu Gly Leu  Ser Asn Ile Lys Phe  Arg Pro Gly 
    1085                 1090                 1095             


Ser Val  Val Val Gln Leu Thr  Leu Ala Phe Arg Glu  Gly Thr Ile 
    1100                 1105                 1110             


Asn Val  His Asp Val Glu Thr  Gln Phe Asn Gln Tyr  Lys Thr Glu 
    1115                 1120                 1125             


Ala Ala  Ser Arg Tyr Asn Leu  Thr Ile Ser Asp Val  Ser Val Ser 
    1130                 1135                 1140             


Asp Val  Pro Phe Pro Phe Ser  Ala Gln Ser Gly Ala  Gly Val Pro 
    1145                 1150                 1155             


Gly Trp  Gly Ile Ala Leu Leu  Val Leu Val Cys Val  Leu Val Ala 
    1160                 1165                 1170             


Leu Ala  Ile Val Tyr Leu Ile  Ala Leu Ala Val Cys  Gln Cys Arg 
    1175                 1180                 1185             


Arg Lys  Asn Tyr Gly Gln Leu  Asp Ile Phe Pro Ala  Arg Asp Thr 
    1190                 1195                 1200             


Tyr His  Pro Met Ser Glu Tyr  Pro Thr Tyr His Thr  His Gly Arg 
    1205                 1210                 1215             


Tyr Val  Pro Pro Ser Ser Thr  Asp Arg Ser Pro Tyr  Glu Lys Val 
    1220                 1225                 1230             


Ser Ala  Gly Asn Gly Gly Ser  Ser Leu Ser Tyr Thr  Asn Pro Ala 
    1235                 1240                 1245             


Val Ala  Ala Thr Ser Ala Asn  Leu 
    1250                 1255     


<210>  48
<211>  1257
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  polyethylene glycol (PEG)

<400>  48

Xaa Xaa Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu 
1               5                   10                  15      


Leu Thr Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr 
            20                  25                  30          


Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro 
        35                  40                  45              


Ser Ser Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser 
    50                  55                  60                  


Ser His Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val 
65                  70                  75                  80  


Thr Leu Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp 
                85                  90                  95      


Gly Gln Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser 
            100                 105                 110         


Thr Thr Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro 
        115                 120                 125             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    130                 135                 140                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
145                 150                 155                 160 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                165                 170                 175     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            180                 185                 190         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        195                 200                 205             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    210                 215                 220                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
225                 230                 235                 240 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                245                 250                 255     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            260                 265                 270         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        275                 280                 285             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    290                 295                 300                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
305                 310                 315                 320 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                325                 330                 335     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            340                 345                 350         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        355                 360                 365             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    370                 375                 380                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
385                 390                 395                 400 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                405                 410                 415     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            420                 425                 430         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        435                 440                 445             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    450                 455                 460                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
465                 470                 475                 480 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                485                 490                 495     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            500                 505                 510         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        515                 520                 525             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    530                 535                 540                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
545                 550                 555                 560 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                565                 570                 575     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            580                 585                 590         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        595                 600                 605             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    610                 615                 620                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
625                 630                 635                 640 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                645                 650                 655     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            660                 665                 670         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        675                 680                 685             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    690                 695                 700                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
705                 710                 715                 720 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                725                 730                 735     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            740                 745                 750         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        755                 760                 765             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    770                 775                 780                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
785                 790                 795                 800 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                805                 810                 815     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            820                 825                 830         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        835                 840                 845             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    850                 855                 860                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
865                 870                 875                 880 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                885                 890                 895     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            900                 905                 910         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        915                 920                 925             


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    930                 935                 940                 


Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val 
945                 950                 955                 960 


Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His 
                965                 970                 975     


Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr 
            980                 985                 990         


Pro Phe Ser Ile Pro Ser His His  Ser Asp Thr Pro Thr  Thr Leu Ala 
        995                 1000                 1005             


Ser His  Ser Thr Lys Thr Asp  Ala Ser Ser Thr His  His Ser Ser 
    1010                 1015                 1020             


Val Pro  Pro Leu Thr Ser Ser  Asn His Ser Thr Ser  Pro Gln Leu 
    1025                 1030                 1035             


Ser Thr  Gly Val Ser Phe Phe  Phe Leu Ser Phe His  Ile Ser Asn 
    1040                 1045                 1050             


Leu Gln  Phe Asn Ser Ser Leu  Glu Asp Pro Ser Thr  Asp Tyr Tyr 
    1055                 1060                 1065             


Gln Glu  Leu Gln Arg Asp Ile  Ser Glu Met Phe Leu  Gln Ile Tyr 
    1070                 1075                 1080             


Lys Gln  Gly Gly Phe Leu Gly  Leu Ser Asn Ile Lys  Phe Arg Pro 
    1085                 1090                 1095             


Gly Ser  Val Val Val Gln Leu  Thr Leu Ala Phe Arg  Glu Gly Thr 
    1100                 1105                 1110             


Ile Asn  Val His Asp Val Glu  Thr Gln Phe Asn Gln  Tyr Lys Thr 
    1115                 1120                 1125             


Glu Ala  Ala Ser Arg Tyr Asn  Leu Thr Ile Ser Asp  Val Ser Val 
    1130                 1135                 1140             


Ser Asp  Val Pro Phe Pro Phe  Ser Ala Gln Ser Gly  Ala Gly Val 
    1145                 1150                 1155             


Pro Gly  Trp Gly Ile Ala Leu  Leu Val Leu Val Cys  Val Leu Val 
    1160                 1165                 1170             


Ala Leu  Ala Ile Val Tyr Leu  Ile Ala Leu Ala Val  Cys Gln Cys 
    1175                 1180                 1185             


Arg Arg  Lys Asn Tyr Gly Gln  Leu Asp Ile Phe Pro  Ala Arg Asp 
    1190                 1195                 1200             


Thr Tyr  His Pro Met Ser Glu  Tyr Pro Thr Tyr His  Thr His Gly 
    1205                 1210                 1215             


Arg Tyr  Val Pro Pro Ser Ser  Thr Asp Arg Ser Pro  Tyr Glu Lys 
    1220                 1225                 1230             


Val Ser  Ala Gly Asn Gly Gly  Ser Ser Leu Ser Tyr  Thr Asn Pro 
    1235                 1240                 1245             


Ala Val  Ala Ala Thr Ser Ala  Asn Leu 
    1250                 1255         


<210>  49
<211>  1261
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Alexa Fluor 594

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  polyethylene glycol (PEG)

<400>  49

Xaa Lys Lys Lys Lys Xaa Met Thr Pro Gly Thr Gln Ser Pro Phe Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val Thr Gly Ser Gly His 
            20                  25                  30          


Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg 
        35                  40                  45              


Ser Ser Val Pro Ser Ser Thr Glu Lys Asn Ala Val Ser Met Thr Ser 
    50                  55                  60                  


Ser Val Leu Ser Ser His Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln 
65                  70                  75                  80  


Gly Gln Asp Val Thr Leu Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser 
                85                  90                  95      


Ala Ala Thr Trp Gly Gln Asp Val Thr Ser Val Pro Val Thr Arg Pro 
            100                 105                 110         


Ala Leu Gly Ser Thr Thr Pro Pro Ala His Asp Val Thr Ser Ala Pro 
        115                 120                 125             


Asp Asn Lys Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    130                 135                 140                 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
145                 150                 155                 160 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                165                 170                 175     


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
            180                 185                 190         


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
        195                 200                 205             


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    210                 215                 220                 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
225                 230                 235                 240 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                245                 250                 255     


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
            260                 265                 270         


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
        275                 280                 285             


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    290                 295                 300                 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
305                 310                 315                 320 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                325                 330                 335     


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
            340                 345                 350         


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
        355                 360                 365             


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    370                 375                 380                 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
385                 390                 395                 400 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                405                 410                 415     


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
            420                 425                 430         


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
        435                 440                 445             


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    450                 455                 460                 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
465                 470                 475                 480 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                485                 490                 495     


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
            500                 505                 510         


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
        515                 520                 525             


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    530                 535                 540                 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
545                 550                 555                 560 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                565                 570                 575     


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
            580                 585                 590         


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
        595                 600                 605             


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    610                 615                 620                 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
625                 630                 635                 640 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                645                 650                 655     


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
            660                 665                 670         


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
        675                 680                 685             


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    690                 695                 700                 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
705                 710                 715                 720 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                725                 730                 735     


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
            740                 745                 750         


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
        755                 760                 765             


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    770                 775                 780                 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
785                 790                 795                 800 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                805                 810                 815     


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
            820                 825                 830         


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
        835                 840                 845             


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    850                 855                 860                 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
865                 870                 875                 880 


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
                885                 890                 895     


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
            900                 905                 910         


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
        915                 920                 925             


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
    930                 935                 940                 


Thr Ser Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro 
945                 950                 955                 960 


Val His Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser 
                965                 970                 975     


Thr Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala 
            980                 985                 990         


Ser Lys Ser Thr Pro Phe Ser Ile  Pro Ser His His Ser  Asp Thr Pro 
        995                 1000                 1005             


Thr Thr  Leu Ala Ser His Ser  Thr Lys Thr Asp Ala  Ser Ser Thr 
    1010                 1015                 1020             


His His  Ser Ser Val Pro Pro  Leu Thr Ser Ser Asn  His Ser Thr 
    1025                 1030                 1035             


Ser Pro  Gln Leu Ser Thr Gly  Val Ser Phe Phe Phe  Leu Ser Phe 
    1040                 1045                 1050             


His Ile  Ser Asn Leu Gln Phe  Asn Ser Ser Leu Glu  Asp Pro Ser 
    1055                 1060                 1065             


Thr Asp  Tyr Tyr Gln Glu Leu  Gln Arg Asp Ile Ser  Glu Met Phe 
    1070                 1075                 1080             


Leu Gln  Ile Tyr Lys Gln Gly  Gly Phe Leu Gly Leu  Ser Asn Ile 
    1085                 1090                 1095             


Lys Phe  Arg Pro Gly Ser Val  Val Val Gln Leu Thr  Leu Ala Phe 
    1100                 1105                 1110             


Arg Glu  Gly Thr Ile Asn Val  His Asp Val Glu Thr  Gln Phe Asn 
    1115                 1120                 1125             


Gln Tyr  Lys Thr Glu Ala Ala  Ser Arg Tyr Asn Leu  Thr Ile Ser 
    1130                 1135                 1140             


Asp Val  Ser Val Ser Asp Val  Pro Phe Pro Phe Ser  Ala Gln Ser 
    1145                 1150                 1155             


Gly Ala  Gly Val Pro Gly Trp  Gly Ile Ala Leu Leu  Val Leu Val 
    1160                 1165                 1170             


Cys Val  Leu Val Ala Leu Ala  Ile Val Tyr Leu Ile  Ala Leu Ala 
    1175                 1180                 1185             


Val Cys  Gln Cys Arg Arg Lys  Asn Tyr Gly Gln Leu  Asp Ile Phe 
    1190                 1195                 1200             


Pro Ala  Arg Asp Thr Tyr His  Pro Met Ser Glu Tyr  Pro Thr Tyr 
    1205                 1210                 1215             


His Thr  His Gly Arg Tyr Val  Pro Pro Ser Ser Thr  Asp Arg Ser 
    1220                 1225                 1230             


Pro Tyr  Glu Lys Val Ser Ala  Gly Asn Gly Gly Ser  Ser Leu Ser 
    1235                 1240                 1245             


Tyr Thr  Asn Pro Ala Val Ala  Ala Thr Ser Ala Asn  Leu 
    1250                 1255                 1260     


<210>  50
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  50

Thr Val Leu Thr Ala Ala 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  51

Thr Leu Val Thr Leu Leu 
1               5       


<210>  52
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  52

Thr Ala Ile Thr Ile Ile 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  53

Ser Val Leu Thr Val Val 
1               5       


<210>  54
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  54

Ser Val Leu Ser Val Val 
1               5       


<210>  55
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  55

Ser Val Leu Thr Val Val 
1               5       


<210>  56
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  56

Thr Val Leu Thr Val Val 
1               5       


<210>  57
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  57

Val Val Val Val Val Thr Val Val Thr Val Val 
1               5                   10      


<210>  58
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  58

Ala Ala Ala Ala Ala Thr Val Ala Thr Val Val 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  59

Ile Ile Ile Ile Ile Thr Val Ile Thr Val Val 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  60

Leu Leu Leu Leu Leu Thr Leu Leu Thr Leu Leu 
1               5                   10      


<210>  61
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  61

Leu Leu Leu Leu Leu Ser Val Leu Thr Val Val 
1               5                   10      


<210>  62
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  62

Leu Leu Leu Leu Leu Ser Val Leu Ser Val Val 
1               5                   10      


<210>  63
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  63

Leu Leu Leu Leu Leu Thr Val Leu Thr Val Val 
1               5                   10      


<210>  64
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            580                 585                 590         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                805                 810                 815     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            820                 825                 830         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        835                 840                 845             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    850                 855                 860                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
865                 870                 875                 880 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                885                 890                 895     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            900                 905                 910         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        915                 920                 925             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
    930                 935                 940                 


Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
945                 950                 955                 960 


Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                965                 970                 975     


Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
            980                 985                 990         


Ser Ile Pro Ser His His Ser Asp  Thr Pro Thr Thr Leu  Ala Ser His 
        995                 1000                 1005             


Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His His Ser  Ser Val Pro 
    1010                 1015                 1020             


Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser Pro Gln  Leu Ser Thr 
    1025                 1030                 1035             


Gly Val  Ser Phe Phe Phe Leu  Ser Phe His Ile Ser  Asn Leu Gln 
    1040                 1045                 1050             


Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr Asp Tyr  Tyr Gln Glu 
    1055                 1060                 1065             


Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu Gln Ile  Tyr Lys Gln 
    1070                 1075                 1080             


Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys Phe Arg  Pro Gly Ser 
    1085                 1090                 1095             


Val Val  Val Gln Leu Thr Leu  Ala Phe Arg Glu Gly  Thr Ile Asn 
    1100                 1105                 1110             


Val His  Asp Val Glu Thr Gln  Phe Asn Gln Tyr Lys  Thr Glu Ala 
    1115                 1120                 1125             


Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp Val Ser  Val Ser Asp 
    1130                 1135                 1140             


Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly Ala Gly  Val Pro Gly 
    1145                 1150                 1155             


Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys Val Leu  Val Ala Leu 
    1160                 1165                 1170             


Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val Cys Gln  Cys Arg Arg 
    1175                 1180                 1185             


Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro Ala Arg  Asp Thr Tyr 
    1190                 1195                 1200             


His Pro  Met Ser Glu Tyr Pro  Thr Tyr His Thr His  Gly Arg Tyr 
    1205                 1210                 1215             


Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro Tyr Glu  Lys Val Ser 
    1220                 1225                 1230             


Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr Thr Asn  Pro Ala Val 
    1235                 1240                 1245             


Ala Ala  Thr Ser Ala Asn Leu  
    1250                 1255 


