                         SEQUENCE LISTING

<110>  PENTAVALENT BIO SCIENCES PVT LTD
 
<120>  Live Attenuated Universal Influenza Virus Vaccines, Methods and 
       Uses thereof

<130>  PCT00892

<140>
<141>

<150>  201941008237
<151>  2019-06-02

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1695
<212>  DNA
<213>  Artificial

<220>
<223>  Functional Heamagglutinin: fHA of Influenza H1N1

<400>  1
atgaaggcaa aactactggt cctgttatat gcatttgtag ctacagatgc agacacaata       60

tgtataggct accatgcgaa caactcaacc gacactgttg acacaatatt cgagaagaat      120

gtggcagtga cacattctgt taacctgctc gaagacagac acaacgggaa actatgtaaa      180

ttaaaaggaa tagccccact acaattgggg aaatgtaaca tcaccggatg gctcttggga      240

aatccagaat gcgactcact gcttccagcg agatcatggt cctacattgt agaaacacca      300

aactctgaga atggagcatg ttatccagga gatttcatcg actatgagga actgagggag      360

caattgagct cagtatcatc attagaaaga ttcgaaatat ttcccaagga aagttcatgg      420

cccaaccaca cattcaacgg agtaacagta tcatgctccc ataggggaaa aagcagtttt      480

tacagaaatt tgctatggct gacgaagaag ggggattcat acccaaagct gaccaattcc      540

tatgtgaaca ataaagggaa agaagtcctt gtactatggg gtgttcatca cccgtccagc      600

agtgatgagc aacagagtct ctatagtaat ggaaatgctt atgtctctgt agcgtcttca      660

aattataaca ggagattcac cccggaaata gctgcaaggc ccaaagtaaa agatcaacat      720

gggaggatga actattactg gaccttgcta gaacccggag acacaataat atttgaggca      780

actggtaatc taatagcacc atggtatgct ttcgcactga gtagagggtt tgagtccggc      840

atcatcacct caaacgcgtc aatgcatgag tgtaacacga agtgtcaaac accccaggga      900

tctataaaca gcaatctccc tttccagaat atacacccag tcacaatagg agagtgccca      960

aaatatgtca ggagtaccaa attgaggatg gttacaggac taagaaacat cccatccatt     1020

caatacagag gtctatttgg agccattgct ggttttattg aggggggatg gactggaatg     1080

atagatggat ggtatggtta tcatcatcag aatgaacagg gatcaggcta tgcagcggat     1140

caaaaaagca cacagaatgc cattaacggg attacaaaca aggtgaactc tgttatcgag     1200

aaaatgaaca ctcaattcac agctgtgggt aaagaattca acaacttaga aaaaaggatg     1260

gaaaatttaa ataaaaaagt tgatgatggg tttctggaca tttggacata taatgcagaa     1320

ttgttagttc tactggaaaa tgaaagaact ttggatttcc atgacttaaa tgtgaagaat     1380

ctgtacgaga aagtaaaaag ccaattaaag aataatgcca aagaaatcgg aaatgggtgt     1440

tttgagttct accacaagtg tgacaatgaa tgcatggaaa gtgtaagaaa tgggacttat     1500

gattatccaa aatattcaga agaatcaaag ttgaacaggg aaaagataga tggagtgaaa     1560

ttggaatcaa tgggggtgta tcagattctg gcgatctact caactgtcgc cagttcactg     1620

gtgcttttgg tctccctggg ggcaatcagt ttctggatgt gttctaatgg gtctttgcag     1680

tgcagaatat gcatc                                                      1695


<210>  2
<211>  565
<212>  PRT
<213>  Artificial

<220>
<223>  Functional Heamagglutinin: fHA, of Influenza H1N1

<400>  2

Met Lys Ala Lys Leu Leu Val Leu Leu Tyr Ala Phe Val Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Ile Phe Glu Lys Asn Val Ala Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Thr Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Ser Leu Leu Pro Ala Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ala Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Leu 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr 
    130                 135                 140                 


Phe Asn Gly Val Thr Val Ser Cys Ser His Arg Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Lys Lys Gly Asp Ser Tyr Pro Lys 
                165                 170                 175     


Leu Thr Asn Ser Tyr Val Asn Asn Lys Gly Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Val His His Pro Ser Ser Ser Asp Glu Gln Gln Ser Leu Tyr 
        195                 200                 205             


Ser Asn Gly Asn Ala Tyr Val Ser Val Ala Ser Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Ala Arg Pro Lys Val Lys Asp Gln His 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Glu Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ser Ile Asn Ser 
    290                 295                 300                 


Asn Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Ile Pro Ser Ile Gln Tyr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Leu Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  3
<211>  1014
<212>  DNA
<213>  Artificial

<220>
<223>  Truncated Heamagglutinin: tHA of Influenza H1N1

<400>  3
atgaaggcaa aactactggt cctgttatat gcatttgtag ctacagatgc agacacaata       60

tgtataggct accatgcgaa caactcaacc gacactgttg acacaatatt cgagaagaat      120

gtggcagtga cacattctgt taacctgctc gaagacagac acaacgggaa actatgtggc      180

ggagggggct gtaacacgaa gtgtcaaaca ccccagggat ctataaacag caatctccct      240

ttccagaata tacacccagt cacaatagga gagtgcccaa aatatgtcag gagtaccaaa      300

ttgaggatgg ttacaggact aagaaacatc ccatccattc aatacagagg tctatttgga      360

gccattgctg gttttattga ggggggatgg actggaatga tagatggatg gtatggttat      420

catcatcaga atgaacaggg atcaggctat gcagcggatc aaaaaagcac acagaatgcc      480

attaacggga ttacaaacaa ggtgaactct gttatcgaga aaatgaacac tcaattcaca      540

gctgtgggta aagaattcaa caacttagaa aaaaggatgg aaaatttaaa taaaaaagtt      600

gatgatgggt ttctggacat ttggacatat aatgcagaat tgttagttct actggaaaat      660

gaaagaactt tggatttcca tgacttaaat gtgaagaatc tgtacgagaa agtaaaaagc      720

caattaaaga ataatgccaa agaaatcgga aatgggtgtt ttgagttcta ccacaagtgt      780

gacaatgaat gcatggaaag tgtaagaaat gggacttatg attatccaaa atattcagaa      840

gaatcaaagt tgaacaggga aaagatagat ggagtgaaat tggaatcaat gggggtgtat      900

cagattctgg cgatctactc aactgtcgcc agttcactgg tgcttttggt ctccctgggg      960

gcaatcagtt tctggatgtg ttctaatggg tctttgcagt gcagaatatg catc           1014


<210>  4
<211>  338
<212>  PRT
<213>  Artificial

<220>
<223>  Truncated Heamagglutinin: tHA of Influenza H1N1

<400>  4

Met Lys Ala Lys Leu Leu Val Leu Leu Tyr Ala Phe Val Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Ile Phe Glu Lys Asn Val Ala Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Gly Gly Gly Gly Cys 
    50                  55                  60                  


Asn Thr Lys Cys Gln Thr Pro Gln Gly Ser Ile Asn Ser Asn Leu Pro 
65                  70                  75                  80  


Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro Lys Tyr Val 
                85                  90                  95      


Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Ser 
            100                 105                 110         


Ile Gln Tyr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly 
        115                 120                 125             


Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His His Gln Asn 
    130                 135                 140                 


Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala 
145                 150                 155                 160 


Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn 
                165                 170                 175     


Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn Leu Glu Lys Arg 
            180                 185                 190         


Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp 
        195                 200                 205             


Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu 
    210                 215                 220                 


Asp Phe His Asp Leu Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser 
225                 230                 235                 240 


Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe 
                245                 250                 255     


Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr 
            260                 265                 270         


Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys 
        275                 280                 285             


Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln Ile Leu Ala 
    290                 295                 300                 


Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val Ser Leu Gly 
305                 310                 315                 320 


Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile 
                325                 330                 335     


Cys Ile 
        


<210>  5
<211>  1410
<212>  DNA
<213>  Artificial

<220>
<223>  Neuraminidase: NA of Influenza H1N1

<400>  5
agcaaaagca ggagtttaaa atgaatccaa accagaaaat aataaccatt gggtcaatct       60

gtatggtagt cggaataatt agcctaatat tgcaaatagg aaatataatc tcaatatgga      120

ttagccattc aattcaaacc ggaaatcaaa accatactgg aatatgcaac caaggcagca      180

ttacctataa agttgttgct gggcaggact caacttcagt gatattaacc ggcaattcat      240

ctctttgtcc catccgtggg tgggctatac acagcaaaga caatggcata agaattggtt      300

ccaaaggaga cgtttttgtc ataagagagc cttttatttc atgttctcac ttggaatgca      360

ggaccttttt tctgactcaa ggcgccttac tgaatgacaa gcattcaagg gggaccttta      420

aggacagaag cccttatagg gccttaatga gctgccctgt cggtgaagct ccgtccccgt      480

acaattcaag gtttgaatcg gttgcttggt cagcaagtgc atgtcatgat ggagtgggct      540

ggctaacaat cggaatttct ggtccagatg atggagcagt ggctgtatta aaatacaacc      600

gcataataac tgaaaccata aaaagttgga ggaagaatat attgagaaca caagagtctg      660

aatgtacctg tgtaaatggt tcatgtttta ccataatgac cgatggccca agtgatgggc      720

tggcctcgta caaaattttc aagatcgaga aggggaaggt tactaaatca atagagttga      780

atgcacctaa ttctcactac gaggaatgtt cctgttaccc tgataccggc aaagtgatgt      840

gtgtgtgcag agacaattgg cacggttcga accgaccatg ggtgtccttc gaccaaaacc      900

tagattataa aataggatac atctgcagtg gggttttcgg tgacaacccg cgtcccaaag      960

atggaacagg cagctgtggc ccagtgtctg ctgatggagc aaacggagta aagggatttt     1020

catataagta tggcaatggt gtttggatag gaaggactaa aagtgacagt tccagacatg     1080

ggtttgagat gatttgggat cctaatggat ggacagagac tgatagtagg ttctctatga     1140

gacaagatgt tgtggcaata actaatcggt cagggtacag cggaagtttc gttcaacatc     1200

ctgagctaac agggctagac tgtatgaggc cttgcttctg ggttgaatta atcagggggc     1260

tacctgagga ggacgcaatc tggactagtg ggagcatcat ttctttttgt ggtgtgaata     1320

gtgatactgt agattggtct tggccagacg gtgctgagtt gccgttcacc attgacaagt     1380

agtctgttca aaaaactcct tgtttctact                                      1410


<210>  6
<211>  453
<212>  PRT
<213>  Artificial

<220>
<223>  Neuraminidase: NA-Influenza H1N1

<400>  6

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val 
1               5                   10                  15      


Val Gly Ile Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Asn Gln Asn His Thr Gly Ile 
        35                  40                  45              


Cys Asn Gln Gly Ser Ile Thr Tyr Lys Val Val Ala Gly Gln Asp Ser 
    50                  55                  60                  


Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile Arg Gly 
65                  70                  75                  80  


Trp Ala Ile His Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Lys Gly 
                85                  90                  95      


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu 
            100                 105                 110         


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
        115                 120                 125             


Ser Arg Gly Thr Phe Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser 
    130                 135                 140                 


Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
145                 150                 155                 160 


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Val Gly Trp Leu Thr 
                165                 170                 175     


Ile Gly Ile Ser Gly Pro Asp Asp Gly Ala Val Ala Val Leu Lys Tyr 
            180                 185                 190         


Asn Arg Ile Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Asn Ile Leu 
        195                 200                 205             


Arg Thr Gln Glu Ser Glu Cys Thr Cys Val Asn Gly Ser Cys Phe Thr 
    210                 215                 220                 


Ile Met Thr Asp Gly Pro Ser Asp Gly Leu Ala Ser Tyr Lys Ile Phe 
225                 230                 235                 240 


Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala Pro 
                245                 250                 255     


Asn Ser His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys Val 
            260                 265                 270         


Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
        275                 280                 285             


Ser Phe Asp Gln Asn Leu Asp Tyr Lys Ile Gly Tyr Ile Cys Ser Gly 
    290                 295                 300                 


Val Phe Gly Asp Asn Pro Arg Pro Lys Asp Gly Thr Gly Ser Cys Gly 
305                 310                 315                 320 


Pro Val Ser Ala Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr Lys 
                325                 330                 335     


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Asp Ser Ser Arg 
            340                 345                 350         


His Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp 
        355                 360                 365             


Ser Arg Phe Ser Met Arg Gln Asp Val Val Ala Ile Thr Asn Arg Ser 
    370                 375                 380                 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
385                 390                 395                 400 


Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Leu Pro Glu 
                405                 410                 415     


Glu Asp Ala Ile Trp Thr Ser Gly Ser Ile Ile Ser Phe Cys Gly Val 
            420                 425                 430         


Asn Ser Asp Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
        435                 440                 445             


Phe Thr Ile Asp Lys 
    450             


<210>  7
<211>  2341
<212>  DNA
<213>  Artificial

<220>
<223>  Polymerase: PB1 of Influenza H1N1

<400>  7
agcgaaagca ggcaaaccat ttgaatggat gtcaatccga ctttactttt cttaaaagtg       60

ccagcacaaa atgctataag cacaactttc ccttatactg gagaccctcc ttacagccat      120

gggacaggaa caggatacac catggatact gtcaacagga cacatcagta ctcagaaagg      180

ggaagatgga caacaaacac cgaaactgga gcaccgcaac tcaacccgat tgatgggcca      240

ctgccagaag acaatgaacc aagtggttat gcccaaacag attgtgtatt ggaagcaatg      300

gccttccttg aggaatccca tcctggtatc tttgagacct cgtgtcttga aacgatggag      360

gttgttcagc aaacacgagt ggacaagctg acacaaggcc gacagaccta tgactggact      420

ctaaatagga accagcctgc tgcaacagca ttggccaaca caatagaagt gttcagatca      480

aatggcctca cggccaatga atctggaagg ctcatagact tccttaagga tgtaatggag      540

tcaatgaaca aagaagaaat ggagatcaca actcattttc agagaaagag acgagtgaga      600

gacaatatga ctaagaaaat ggtgacacag agaacaatag gtaaaaggaa gcagagattg      660

aacaaaagga gttatctaat tagggcatta accctgaaca caatgaccaa agatgctgag      720

agagggaagc taaaacggag agcaattgca accccaggga tgcaaataag ggggtttgta      780

tactttgttg agacactagc aaggagtata tgtgagaaac ttgaacaatc aggattgcca      840

gttggaggca atgagaagaa agcaaagttg gcaaatgttg taaggaagat gatgaccaat      900

tctcaggaca ctgaaatttc tttcaccatc actggagata acaccaaatg gaacgaaaat      960

cagaaccctc ggatgttttt ggccatgatc acatatataa ccagaaatca gcccgaatgg     1020

ttcagaaatg ttctaagtat tgctccaata atgttctcaa acaaaatggc gagactggga     1080

aaggggtaca tgtttgagag caagagtatg aaaattagaa ctcaaatacc tgcagaaatg     1140

ctagcaagca tcgatttgaa atacttcaat gattcaacta gaaagaagat tgaaaaaatc     1200

cggccgctct taatagatgg gactgcatca ttgagccctg gaatgatgat gggcatgttc     1260

aatatgttaa gtactgtatt aggcgtctcc atcctgaatc ttggacaaaa gagacacacc     1320

aagactactt actggtggga tggtcttcaa tcttctgatg attttgctct gattgtgaat     1380

gcacccaatc atgaagggat tcaagccgga gtcaacaggt tttatcgaac ctgtaagcta     1440

cttggaatta atatgagcaa gaaaaagtct tacataaaca gaacaggtac atttgaattc     1500

acaagttttt tctatcgtta tgggtttgtt gccaatttca gcatggagct tcccagcttt     1560

ggggtgtctg ggatcaacga gtctgcggac atgagtattg gagttactgt catcaaaaac     1620

aatatgataa acaatgatct tggtccagca accgctcaaa tggcccttca gctgttcatc     1680

aaagattaca ggtacacgta ccggtgccat agaggtgaca cacaaataca aacccgaaga     1740

tcatttgaaa taaagaaact gtgggagcaa acccattcca aagctggact gctggtctcc     1800

gacggaggcc caaatttata caacattaga aatctccaca ttcctgaagt ctgcttgaaa     1860

tgggaattaa tggatgagga ttaccagggg cgtttatgca acccactgaa cccatttgtc     1920

aaccataaag acattgaatc agtgaacaat gcagtgataa tgccagcaca tggtccagcc     1980

aaaaacatgg agtatgatgc tgttgcaaca acacactcct ggatccccaa aagaaatcga     2040

tccatcttga atacaagcca aagaggaata cttgaagatg aacaaatgta ccaaaagtgc     2100

tgcaacttat ttgaaaaatt cttccccagc agttcataca gaagaccagt cgggatatcc     2160

agtatggtgg aggctatggt ttccagagcc cgaattgatg cacgaattga tttcgaatct     2220

ggaaggataa agaaagagga gttcactgag atcatgaaga tctgttccac cattgaagag     2280

ctcagacggc aaaaatagtg aatttagctt gtccttcatg aaaaaatgcc ttgtttctac     2340

t                                                                     2341


<210>  8
<211>  757
<212>  PRT
<213>  Artificial

<220>
<223>  Polymerase: PB1 of Influenza H1N1

<400>  8

Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Val Pro Ala Gln Asn 
1               5                   10                  15      


Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          


Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              


Tyr Ser Glu Arg Gly Arg Trp Thr Thr Asn Thr Glu Thr Gly Ala Pro 
    50                  55                  60                  


Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  


Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      


Glu Ser His Pro Gly Ile Phe Glu Thr Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         


Val Val Gln Gln Thr Arg Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             


Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 


Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 


Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Met Glu Ser Met Asn Lys 
                165                 170                 175     


Glu Glu Met Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         


Asp Asn Met Thr Lys Lys Met Val Thr Gln Arg Thr Ile Gly Lys Arg 
        195                 200                 205             


Lys Gln Arg Leu Asn Lys Arg Ser Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 


Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 


Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     


Thr Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         


Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             


Met Met Thr Asn Ser Gln Asp Thr Glu Ile Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 


Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala 
305                 310                 315                 320 


Met Ile Thr Tyr Ile Thr Arg Asn Gln Pro Glu Trp Phe Arg Asn Val 
                325                 330                 335     


Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         


Lys Gly Tyr Met Phe Glu Ser Lys Ser Met Lys Ile Arg Thr Gln Ile 
        355                 360                 365             


Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Asp Ser 
    370                 375                 380                 


Thr Arg Lys Lys Ile Glu Lys Ile Arg Pro Leu Leu Ile Asp Gly Thr 
385                 390                 395                 400 


Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     


Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Arg His Thr 
            420                 425                 430         


Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             


Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asn 
    450                 455                 460                 


Arg Phe Tyr Arg Thr Cys Lys Leu Leu Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 


Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     


Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         


Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             


Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 


Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 


Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Ile 
                565                 570                 575     


Lys Lys Leu Trp Glu Gln Thr His Ser Lys Ala Gly Leu Leu Val Ser 
            580                 585                 590         


Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             


Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Gln Gly Arg Leu 
    610                 615                 620                 


Cys Asn Pro Leu Asn Pro Phe Val Asn His Lys Asp Ile Glu Ser Val 
625                 630                 635                 640 


Asn Asn Ala Val Ile Met Pro Ala His Gly Pro Ala Lys Asn Met Glu 
                645                 650                 655     


Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         


Ser Ile Leu Asn Thr Ser Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             


Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 


Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 


Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     


Lys Glu Glu Phe Thr Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         


Leu Arg Arg Gln Lys 
        755         


<210>  9
<211>  2341
<212>  DNA
<213>  Artificial

<220>
<223>  Polymerase: PB2-Influenza H1N1

<400>  9
agcgaaagca ggtcaattat attcaatatg gaaagaataa aagaactaag gaatctaatg       60

tcgcagtctc gcactcgcga gatactcaca aaaaccaccg tggaccatat ggccataatc      120

aagaagtaca catcaggaag acaggagaag aacccagcac ttaggatgaa atggatgatg      180

gcaatgaaat atccaattac agcagacaag aggataacgg aaatgattcc tgagagaaat      240

gagcagggac aaactttatg gagtaaaatg aatgacgccg gatcagaccg agtgatggta      300

tcacctctgg ctgtgacatg gtggaatagg aatggaccag tgacaagtac agttcattat      360

ccaaaaatct acaaaactta ttttgaaaaa gtcgaaaggt taaaacatgg aacctttggc      420

cctgtccatt ttagaaacca agtcaaaata cgtcgaagag ttgacataaa tcctggtcat      480

gcagatctca gtgccaaaga ggcacaggat gtaatcatgg aagttgtttt ccctaacgaa      540

gtgggagcca ggatactaac atcggaatcg caactaacga caaccaaaga gaagaaagaa      600

gaactccagg gttgcaaaat ttctcctctg atggtggcat acatgttgga gagagaactg      660

gtccgcaaaa cgagattcct cccagtggct ggtggaacaa gcagtgtgta cattgaagtg      720

ttgcatttga cccaaggaac atgctgggaa cagatgtaca ctccaggagg ggaggcgagg      780

aatgatgatg ttgatcaaag cttaattatt gctgctagaa acatagtaag aagagccaca      840

gtatcagcag atccactagc atctttattg gagatgtgcc acagcacgca gattggtgga      900

ataaggatgg taaacatcct taggcagaac ccaacagaag agcaagccgt ggatatttgc      960

aaggctgcaa tgggactgag aattagctca tccttcagtt ttggtggatt cacatttaag     1020

agaacaagcg gatcatcagt caagagagag gaagaggtgc ttacgggcaa tcttcagaca     1080

ttgaagataa gagtgcatga gggatatgaa gagttcacaa tggttgggag aagagcaaca     1140

gctatactca gaaaagcaac caggagattg attcagctga tagtgagtgg gagagacgaa     1200

cagtcgattg ccgaagcaat aattgtggcc atggtatttt cacaagagga ttgtatgata     1260

aaagcagtta gaggtgacct gaatttcgtc aatagggcga atcagcgatt gaatcccatg     1320

caccaacttt tgagacattt tcagaaggat gcaaaggtgc tctttcaaaa ttggggaatt     1380

gaatccatcg acaatgtgat gggaatgatc gggatattgc ccgacatgac tccaagcacc     1440

gagatgtcaa tgagaggagt gagaatcagc aaaatggggg tagatgagta ttccagcgcg     1500

gagaagatag tggtgagcat tgaccgtttt ttgagagtta gggaccaacg tgggaatgta     1560

ctactgtctc ccgaggagat cagtgaaaca cagggaacag agaaactgac aataacttac     1620

tcatcgtcaa tgatgtggga gattaatggt cctgaatcag tgttggtcaa tacctatcag     1680

tggatcatca gaaactggga aactgttaaa attcagtggt cccagaatcc tacaatgctg     1740

tacaataaaa tggaatttga gccatttcag tctttagttc caaaggccgt tagaggccaa     1800

tacagtgggt ttgtgagaac tctgttccaa caaatgaggg atgtgcttgg gacatttgat     1860

accgctcaga taataaaact tcttcccttc gcagccgctc caccaaagca aagtagaacg     1920

cagttctcct cattgactat aaatgtgagg ggatcaggaa tgagaatact tgtaaggggc     1980

aattctccag tattcaacta caacaagacc actaaaagac tcacagttct cggaaaggat     2040

gctggccctt taactgaaga cccagatgaa ggcacagctg gagttgagtc cgcagttctg     2100

agaggattcc tcattctggg caaagaagac aggagatatg gaccagcatt aagcataaat     2160

gaactgagca accttgcgaa aggagagaag gctaatgtgc taattgggca aggagacgtg     2220

gtgttggtaa tgaaacggaa acggaactct agcatactta ctgacagcca gacagcgacc     2280

aaaagaattc ggatggccat caattagtgt cgaatagttt aaaaacgacc ttgtttctac     2340

t                                                                     2341


<210>  10
<211>  759
<212>  PRT
<213>  Artificial

<220>
<223>  Polymerase: PB2-Influenza H1N1

<400>  10

Met Glu Arg Ile Lys Glu Leu Arg Asn Leu Met Ser Gln Ser Arg Thr 
1               5                   10                  15      


Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          


Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 
        35                  40                  45              


Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Thr 
    50                  55                  60                  


Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 
65                  70                  75                  80  


Met Asn Asp Ala Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      


Thr Trp Trp Asn Arg Asn Gly Pro Val Thr Ser Thr Val His Tyr Pro 
            100                 105                 110         


Lys Ile Tyr Lys Thr Tyr Phe Glu Lys Val Glu Arg Leu Lys His Gly 
        115                 120                 125             


Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 
    130                 135                 140                 


Val Asp Ile Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 
145                 150                 155                 160 


Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 
                165                 170                 175     


Leu Thr Ser Glu Ser Gln Leu Thr Thr Thr Lys Glu Lys Lys Glu Glu 
            180                 185                 190         


Leu Gln Gly Cys Lys Ile Ser Pro Leu Met Val Ala Tyr Met Leu Glu 
        195                 200                 205             


Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 
    210                 215                 220                 


Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 
225                 230                 235                 240 


Glu Gln Met Tyr Thr Pro Gly Gly Glu Ala Arg Asn Asp Asp Val Asp 
                245                 250                 255     


Gln Ser Leu Ile Ile Ala Ala Arg Asn Ile Val Arg Arg Ala Thr Val 
            260                 265                 270         


Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 
        275                 280                 285             


Ile Gly Gly Ile Arg Met Val Asn Ile Leu Arg Gln Asn Pro Thr Glu 
    290                 295                 300                 


Glu Gln Ala Val Asp Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 
305                 310                 315                 320 


Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 
                325                 330                 335     


Ser Val Lys Arg Glu Glu Glu Val Leu Thr Gly Asn Leu Gln Thr Leu 
            340                 345                 350         


Lys Ile Arg Val His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg 
        355                 360                 365             


Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 
    370                 375                 380                 


Ile Val Ser Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 
385                 390                 395                 400 


Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 
                405                 410                 415     


Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 
            420                 425                 430         


Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 
        435                 440                 445             


Trp Gly Ile Glu Ser Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu 
    450                 455                 460                 


Pro Asp Met Thr Pro Ser Thr Glu Met Ser Met Arg Gly Val Arg Ile 
465                 470                 475                 480 


Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Ala Glu Lys Ile Val Val 
                485                 490                 495     


Ser Ile Asp Arg Phe Leu Arg Val Arg Asp Gln Arg Gly Asn Val Leu 
            500                 505                 510         


Leu Ser Pro Glu Glu Ile Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 
        515                 520                 525             


Ile Thr Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 
    530                 535                 540                 


Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Thr Val 
545                 550                 555                 560 


Lys Ile Gln Trp Ser Gln Asn Pro Thr Met Leu Tyr Asn Lys Met Glu 
                565                 570                 575     


Phe Glu Pro Phe Gln Ser Leu Val Pro Lys Ala Val Arg Gly Gln Tyr 
            580                 585                 590         


Ser Gly Phe Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly 
        595                 600                 605             


Thr Phe Asp Thr Ala Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 
    610                 615                 620                 


Pro Pro Lys Gln Ser Arg Thr Gln Phe Ser Ser Leu Thr Ile Asn Val 
625                 630                 635                 640 


Arg Gly Ser Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Val Phe 
                645                 650                 655     


Asn Tyr Asn Lys Thr Thr Lys Arg Leu Thr Val Leu Gly Lys Asp Ala 
            660                 665                 670         


Gly Pro Leu Thr Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser 
        675                 680                 685             


Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asp Arg Arg Tyr 
    690                 695                 700                 


Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Asn Leu Ala Lys Gly Glu 
705                 710                 715                 720 


Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 
                725                 730                 735     


Arg Lys Arg Asn Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 
            740                 745                 750         


Arg Ile Arg Met Ala Ile Asn 
        755                 


<210>  11
<211>  2233
<212>  DNA
<213>  Artificial

<220>
<223>  Polymerase: PA of Influenza H1N1

<400>  11
agcgaaagca ggtactgatt caaaatggaa gattttgtgc gacaatgctt caatccgatg       60

attgtcgagc ttgcggaaaa ggcaatgaaa gagtatggag aggacctgaa aatcgaaaca      120

aacaaatttg cagcaatatg cactcacttg gaagtgtgct tcatgtattc agattttcac      180

ttcatcgatg agcaaggcga gtcaatagtc gtagaacttg gcgatccaaa tgcacttttg      240

aagcacagat ttgaaataat cgagggaaga gatcgcacaa tagcctggac agtaataaac      300

agtatttgca acactacagg ggctgagaaa ccaaagtttc taccagattt gtatgattac      360

aagaagaata gattcatcga aattggagta acaaggagag aagttcacat atactatctg      420

gaaaaggcca ataaaattaa atctgagaag acacacatcc acattttctc attcactggg      480

gaggaaatgg ccacaaaggc cgactacact ctcgatgaag aaagcagggc taggatcaaa      540

accaggctat tcaccataag acaagaaatg gctagcagag gcctctggga ttcctttcgt      600

cagtccgaga gaggcgaaga gacaattgaa gaaagatttg aaatcacagg aacaatgcgc      660

aagcttgccg accaaagtct cccgccaaac ttctccagcc ttgaaaaatt tagagcctat      720

gtggatggat tcgaaccgaa cggctacatt gagggcaagc tttctcaaat gtccaaagaa      780

gtaaatgcta gaattgaacc ttttttgaaa tcaacaccac gaccacttag acttccggat      840

gggcctccct gttctcagcg gtccaaattc ctgctgatgg atgccttaaa attaagcatt      900

gaggacccaa gtcatgaggg agaggggata ccgctatatg atgcaatcaa atgcatgaga      960

acattctttg gatggaagga acccaatgtt gttaaaccac acgaaaaggg aataaatcca     1020

aattatcttc tgtcatggaa gcaagtactg gcagaactgc aggacattga gaatgaggag     1080

aaaattccaa ggactaaaaa tatgaagaaa acgagtcagt taaagtgggc acttggtgag     1140

aacatggcac cagaaaaggt agactttgac gattgtaaag atgtaggcga tttgaagcaa     1200

tatgatagtg atgaaccaga attgaggtcg cttgcaagtt ggattcagaa tgagttcaac     1260

aaggcatgtg aactgaccga ttcaagctgg atagagctcg atgagattgg agaagatgcg     1320

gctccaattg aacacattgc aagcatgaga aggaattatt tcacagcaga ggtgtctcat     1380

tgcagagcca cagaatacat aatgaagggg gtgtacatca atactgcctt gcttaatgca     1440

tcctgtgcag caatggatga tttccaatta attccaatga taagcaagtg tagaactaag     1500

gagggaaggc gaaagaccaa tttgtacggt ttcatcataa aaggaagatc ccacttaagg     1560

aatgacaccg atgtggtaaa ctttgtgagc atggagtttt ccctcactga cccaagactt     1620

gaaccacaca aatgggagaa gtactgtgtt cttgaggtag gagatatgct tctaagaagt     1680

gccataggcc atgtgtcaag gcctatgttc ttgtatgtga ggacaaatgg aacctcaaaa     1740

attaaaatga aatgggggat ggaaatgagg cgttgcctcc ttcagtcact tcaacaaatc     1800

gagagtatga ttgaagctga gtcctctgtc aaggagaaag acatgaccaa agagttcttt     1860

gaaaacaaat cagaaacatg gcccgttgga gagtccccca aaggagtgga ggaaggttcc     1920

attgggaagg tctgcagaac tttattggca aagtcggtat tcaacagctt gtatgcatct     1980

ccacaactag aaggattttc agctgaatca agaaaactgc ttcttatcgt tcaggctctt     2040

agggacaacc tggaacctgg gacctttgat cttggggggc tatatgaagc aattgaggag     2100

tgcctgatta atgatccctg ggttttgctt aatgcttctt ggttcaactc cttcctcaca     2160

catgcattga gatagttgtg gcaatgctac tatttgctat ccatactgtc caaaaaagta     2220

ccttgtttct act                                                        2233


<210>  12
<211>  696
<212>  PRT
<213>  Artificial

<220>
<223>  Polymerase: PA of Influenza H1N1

<400>  12

Met Lys Glu Tyr Gly Glu Asp Leu Lys Ile Glu Thr Asn Lys Phe Ala 
1               5                   10                  15      


Ala Ile Cys Thr His Leu Glu Val Cys Phe Met Tyr Ser Asp Phe His 
            20                  25                  30          


Phe Ile Asp Glu Gln Gly Glu Ser Ile Val Val Glu Leu Gly Asp Pro 
        35                  40                  45              


Asn Ala Leu Leu Lys His Arg Phe Glu Ile Ile Glu Gly Arg Asp Arg 
    50                  55                  60                  


Thr Ile Ala Trp Thr Val Ile Asn Ser Ile Cys Asn Thr Thr Gly Ala 
65                  70                  75                  80  


Glu Lys Pro Lys Phe Leu Pro Asp Leu Tyr Asp Tyr Lys Lys Asn Arg 
                85                  90                  95      


Phe Ile Glu Ile Gly Val Thr Arg Arg Glu Val His Ile Tyr Tyr Leu 
            100                 105                 110         


Glu Lys Ala Asn Lys Ile Lys Ser Glu Lys Thr His Ile His Ile Phe 
        115                 120                 125             


Ser Phe Thr Gly Glu Glu Met Ala Thr Lys Ala Asp Tyr Thr Leu Asp 
    130                 135                 140                 


Glu Glu Ser Arg Ala Arg Ile Lys Thr Arg Leu Phe Thr Ile Arg Gln 
145                 150                 155                 160 


Glu Met Ala Ser Arg Gly Leu Trp Asp Ser Phe Arg Gln Ser Glu Arg 
                165                 170                 175     


Gly Glu Glu Thr Ile Glu Glu Arg Phe Glu Ile Thr Gly Thr Met Arg 
            180                 185                 190         


Lys Leu Ala Asp Gln Ser Leu Pro Pro Asn Phe Ser Ser Leu Glu Lys 
        195                 200                 205             


Phe Arg Ala Tyr Val Asp Gly Phe Glu Pro Asn Gly Tyr Ile Glu Gly 
    210                 215                 220                 


Lys Leu Ser Gln Met Ser Lys Glu Val Asn Ala Arg Ile Glu Pro Phe 
225                 230                 235                 240 


Leu Lys Ser Thr Pro Arg Pro Leu Arg Leu Pro Asp Gly Pro Pro Cys 
                245                 250                 255     


Ser Gln Arg Ser Lys Phe Leu Leu Met Asp Ala Leu Lys Leu Ser Ile 
            260                 265                 270         


Glu Asp Pro Ser His Glu Gly Glu Gly Ile Pro Leu Tyr Asp Ala Ile 
        275                 280                 285             


Lys Cys Met Arg Thr Phe Phe Gly Trp Lys Glu Pro Asn Val Val Lys 
    290                 295                 300                 


Pro His Glu Lys Gly Ile Asn Pro Asn Tyr Leu Leu Ser Trp Lys Gln 
305                 310                 315                 320 


Val Leu Ala Glu Leu Gln Asp Ile Glu Asn Glu Glu Lys Ile Pro Arg 
                325                 330                 335     


Thr Lys Asn Met Lys Lys Thr Ser Gln Leu Lys Trp Ala Leu Gly Glu 
            340                 345                 350         


Asn Met Ala Pro Glu Lys Val Asp Phe Asp Asp Cys Lys Asp Val Gly 
        355                 360                 365             


Asp Leu Lys Gln Tyr Asp Ser Asp Glu Pro Glu Leu Arg Ser Leu Ala 
    370                 375                 380                 


Ser Trp Ile Gln Asn Glu Phe Asn Lys Ala Cys Glu Leu Thr Asp Ser 
385                 390                 395                 400 


Ser Trp Ile Glu Leu Asp Glu Ile Gly Glu Asp Ala Ala Pro Ile Glu 
                405                 410                 415     


His Ile Ala Ser Met Arg Arg Asn Tyr Phe Thr Ala Glu Val Ser His 
            420                 425                 430         


Cys Arg Ala Thr Glu Tyr Ile Met Lys Gly Val Tyr Ile Asn Thr Ala 
        435                 440                 445             


Leu Leu Asn Ala Ser Cys Ala Ala Met Asp Asp Phe Gln Leu Ile Pro 
    450                 455                 460                 


Met Ile Ser Lys Cys Arg Thr Lys Glu Gly Arg Arg Lys Thr Asn Leu 
465                 470                 475                 480 


Tyr Gly Phe Ile Ile Lys Gly Arg Ser His Leu Arg Asn Asp Thr Asp 
                485                 490                 495     


Val Val Asn Phe Val Ser Met Glu Phe Ser Leu Thr Asp Pro Arg Leu 
            500                 505                 510         


Glu Pro His Lys Trp Glu Lys Tyr Cys Val Leu Glu Val Gly Asp Met 
        515                 520                 525             


Leu Leu Arg Ser Ala Ile Gly His Val Ser Arg Pro Met Phe Leu Tyr 
    530                 535                 540                 


Val Arg Thr Asn Gly Thr Ser Lys Ile Lys Met Lys Trp Gly Met Glu 
545                 550                 555                 560 


Met Arg Arg Cys Leu Leu Gln Ser Leu Gln Gln Ile Glu Ser Met Ile 
                565                 570                 575     


Glu Ala Glu Ser Ser Val Lys Glu Lys Asp Met Thr Lys Glu Phe Phe 
            580                 585                 590         


Glu Asn Lys Ser Glu Thr Trp Pro Val Gly Glu Ser Pro Lys Gly Val 
        595                 600                 605             


Glu Glu Gly Ser Ile Gly Lys Val Cys Arg Thr Leu Leu Ala Lys Ser 
    610                 615                 620                 


Val Phe Asn Ser Leu Tyr Ala Ser Pro Gln Leu Glu Gly Phe Ser Ala 
625                 630                 635                 640 


Glu Ser Arg Lys Leu Leu Leu Ile Val Gln Ala Leu Arg Asp Asn Leu 
                645                 650                 655     


Glu Pro Gly Thr Phe Asp Leu Gly Gly Leu Tyr Glu Ala Ile Glu Glu 
            660                 665                 670         


Cys Leu Ile Asn Asp Pro Trp Val Leu Leu Asn Ala Ser Trp Phe Asn 
        675                 680                 685             


Ser Phe Leu Thr His Ala Leu Arg 
    690                 695     


<210>  13
<211>  1565
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleoprotein: NP of Influenza H1N1

<400>  13
agcaaaagca gggtagataa tcactcacag agtgacatcg aaatcatggc gaccaaaggc       60

accaaacgat cttacgaaca gatggagact gatggagaac gccagaatgc cactgaaatc      120

agagcatctg tcggaaaaat gattgatgga attggacgat tctacatcca aatgtgcacc      180

gaacttaaac tcagtgatta tgagggacgg ctgattcaga acagcttaac aatagagaga      240

atggtgctct ctgcttttga cgagaggagg aataaatatc tagaagaaca tcccagtgcg      300

gggaaagatc ctaagaaaac tggaggacct atatacagga gagtagatgg aaagtggagg      360

agagaactca tcctttatga caaagaagaa ataagacgaa tctggcgcca agctaataat      420

ggtgacgatg caacggctgg tctgactcac atgatgatct ggcactccaa tttgaatgat      480

gcaacttacc agaggacaag agctcttgtt cgcacaggaa tggatcccag gatgtgctca      540

ctgatgcagg gttcaaccct ccctaggagg tctggggccg caggtgctgc agtcaaagga      600

gttggaacaa tggtgatgga attgatcaga atgatcaaac gtgggatcaa tgatcggaac      660

ttctggaggg gtgagaatgg acggagaaca aggattgctt atgaaagaat gtgcaacatt      720

ctcaaaggga aatttcaaac agctgcacaa agaacaatgg tggatcaagt gagagagagc      780

cggaatccag gaaatgctga gttcgaagat ctcatctttt tagcacggtc tgcactcata      840

ttgagagggt cagttgctca caagtcctgc ctgcctgcct gtgtgtatgg atctgccgta      900

gccagtggat acgactttga aagagaggga tactctctag tcggaataga ccctttcaga      960

ctgcttcaaa acagccaagt atacagccta atcagaccaa atgagaatcc agcacacaag     1020

agtcaactgg tgtggatggc atgccattct gctgcatttg aagatctaag agtatcaagc     1080

ttcatcagag ggacgaaagt ggtcccaaga gggaagcttt ccactagagg agttcaaatt     1140

gcttccaatg aaaacatgga gactatggaa tcaagtaccc ttgaactgag aagcagatac     1200

tgggccataa ggaccagaag tggagggaac accaatcaac agagggcttc ctcgggccaa     1260

atcagcatac aacctacgtt ctcagtacag agaaatctcc cttttgacag accaaccatt     1320

atggcagcat tcactgggaa tacagagggg agaacatctg acatgagaac cgaaatcata     1380

aggctgatgg aaagtgcaag accagaagat gtgtctttcc aggggcgggg agtcttcgag     1440

ctctcggacg aaaaggcaac gagcccgatc gtgccctcct ttgacatgag taatgaagga     1500

tcttatttct tcggagacaa tgcagaggag tacgacaatt aaagaaaaat acccttgttt     1560

ctact                                                                 1565


<210>  14
<211>  498
<212>  PRT
<213>  Artificial

<220>
<223>  Nucleoprotein: NP of Influenza H1N1

<400>  14

Met Ala Thr Lys Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Asp Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Val Asp Gly Lys Trp Arg Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr His Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Arg Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Thr Met Val Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Phe Glu Asp Leu 
                245                 250                 255     


Ile Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Ser Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Arg Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr Lys Val 
            340                 345                 350         


Val Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Glu Thr Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ser Gly Gln Ile Ser Ile Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Asp Arg Pro Thr Ile Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Leu Met 
        435                 440                 445             


Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Thr Ser Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  15
<211>  1014
<212>  DNA
<213>  Artificial

<220>
<223>  Matrix protein: M of Influenza H1N1

<400>  15
agcaaaagca ggtagatatt gaaagatgag tcttctaacc gaggtcgaaa cgtacgttct       60

ctctatcgtc ccgtcaggcc ccctcaaagc cgagatcgca cagagacttg aagatgtctt      120

tgcagggaag aacaccgatc ttgaggttct catggaatgg ctaaagacaa gaccaatcct      180

gtcacctctg actaagggga ttttaggatt tgtgttcacg ctcaccgtgc ccagtgagcg      240

gggactgcag cgtagacgct ttgtccaaaa tgctcttaat gggaacggag atccaaataa      300

catggacaaa gcagttaaac tgtataggaa gcttaagagg gagataacat tccatggggc      360

caaagaaata gcactcagtt attctgctgg tgcacttgcc agttgtatgg gcctcatata      420

caacaggatg ggggctgtga ccactgaagt ggcatttggc ctggtatgcg caacctgtga      480

acagattgct gactcccagc atcggtctca taggcaaatg gtgacaacaa ccaatccact      540

aatcagacat gagaacagaa tggttctagc cagcactaca gctaaggcta tggagcaaat      600

ggctggatcg agtgagcaag cagcagaggc catggatatt gctagtcagg ccaggcaaat      660

ggtgcaggcg atgagaacca ttgggactca tcctagctcc agtgctggtc taaaagatga      720

tcttcttgaa aatttgcagg cctatcagaa acgaatgggg gtgcagatgc aacgattcaa      780

gtgatcctct cgtcattgca gcaaatatca ttgagatctt gcacttgata ttgtggattc      840

ttgatcgtct ttttttcaaa tgcatttatc gtcgctttaa atacggtttg aaaagagggc      900

cttctacgga aggagtgcca gagtctatga gggaagaata tcgaaaggaa cagcagaatg      960

ctgtggatgt tgacgatggt cattttgtca acatagagct ggagtaaaaa acta           1014


<210>  16
<211>  252
<212>  PRT
<213>  Artificial

<220>
<223>  Matrix protein: M of Influenza H1N1

<400>  16

Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Val Pro 
1               5                   10                  15      


Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe 
            20                  25                  30          


Ala Gly Lys Asn Thr Asp Leu Glu Val Leu Met Glu Trp Leu Lys Thr 
        35                  40                  45              


Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 
    50                  55                  60                  


Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val 
65                  70                  75                  80  


Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala 
                85                  90                  95      


Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 
            100                 105                 110         


Lys Glu Ile Ala Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met 
        115                 120                 125             


Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe 
    130                 135                 140                 


Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 
145                 150                 155                 160 


Ser His Arg Gln Met Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu 
                165                 170                 175     


Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met 
            180                 185                 190         


Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Asp Ile Ala Ser Gln 
        195                 200                 205             


Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His Pro Ser 
    210                 215                 220                 


Ser Ser Ala Gly Leu Lys Asp Asp Leu Leu Glu Asn Leu Gln Ala Tyr 
225                 230                 235                 240 


Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 
                245                 250         


<210>  17
<211>  890
<212>  DNA
<213>  Artificial

<220>
<223>  Non-structural protein 1: NS1 of Influenza H1N1

<400>  17
agcaaaagca gggtgacaaa gacataatgg atccaaacac tgtgtcaagc tttcaggtag       60

attgctttct ttggcatgtc cgcaaaagag ttgcagacca agaactaggt gatgccccat      120

tccttgatcg gcttcgccga gatcagaagt ccctaagagg aagaggcagc actctcggtc      180

tggacatcga aacagccacc cgtgctggaa agcaaatagt ggagcggatt ctgaaggaag      240

aatctgatga ggcactcaaa atgaccatgg cctctgtacc tgcatcgcgc tacctaactg      300

acatgactct tgaggaaatg tcaaggcact ggttcatgct catgcccaag cagaaagtgg      360

caggccctct ttgtatcaga atggaccagg cgatcatgga taagaacatc atactgaaag      420

cgaacttcag tgtgattttt gaccggctgg agactctaat attactaagg gccttcaccg      480

aagaggggac aattgttggc gaaatttcac cactgccctc tcttccagga catactgatg      540

aggatgtcaa aaatgcagtt ggggtcctca tcggaggact tgaatggaat aataacacag      600

ttcgagtctc tgaaactcta cagagattcg cttggagaag cagtaatgag aatgggagac      660

ctccactcac tccaaaacag aaacggaaaa tggcgggaac aattaggtca gaagtttgaa      720

gaaataagat ggttgattga agaagtgaga cacagactga agataacaga gaatagtttt      780

gagcaaataa catttatgca agccttacaa ctattgcttg aagtggagca agagataaga      840

actttctcgt ttcagcttat ttaataataa aaaacaccct tgtttctact                 890


<210>  18
<211>  230
<212>  PRT
<213>  Artificial

<220>
<223>  Non-structural protein 1: NS1 of Influenza H1N1

<400>  18

Met Asp Pro Asn Thr Val Ser Ser Phe Gln Val Asp Cys Phe Leu Trp 
1               5                   10                  15      


His Val Arg Lys Arg Val Ala Asp Gln Glu Leu Gly Asp Ala Pro Phe 
            20                  25                  30          


Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly Arg Gly Ser 
        35                  40                  45              


Thr Leu Gly Leu Asp Ile Glu Thr Ala Thr Arg Ala Gly Lys Gln Ile 
    50                  55                  60                  


Val Glu Arg Ile Leu Lys Glu Glu Ser Asp Glu Ala Leu Lys Met Thr 
65                  70                  75                  80  


Met Ala Ser Val Pro Ala Ser Arg Tyr Leu Thr Asp Met Thr Leu Glu 
                85                  90                  95      


Glu Met Ser Arg His Trp Phe Met Leu Met Pro Lys Gln Lys Val Ala 
            100                 105                 110         


Gly Pro Leu Cys Ile Arg Met Asp Gln Ala Ile Met Asp Lys Asn Ile 
        115                 120                 125             


Ile Leu Lys Ala Asn Phe Ser Val Ile Phe Asp Arg Leu Glu Thr Leu 
    130                 135                 140                 


Ile Leu Leu Arg Ala Phe Thr Glu Glu Gly Thr Ile Val Gly Glu Ile 
145                 150                 155                 160 


Ser Pro Leu Pro Ser Leu Pro Gly His Thr Asp Glu Asp Val Lys Asn 
                165                 170                 175     


Ala Val Gly Val Leu Ile Gly Gly Leu Glu Trp Asn Asn Asn Thr Val 
            180                 185                 190         


Arg Val Ser Glu Thr Leu Gln Arg Phe Ala Trp Arg Ser Ser Asn Glu 
        195                 200                 205             


Asn Gly Arg Pro Pro Leu Thr Pro Lys Gln Lys Arg Lys Met Ala Gly 
    210                 215                 220                 


Thr Ile Arg Ser Glu Val 
225                 230 



<210>  19
<211>  1070
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA withstalk domain and 
       conservedglobular regions linked with linker (?HA/H1N1-I)

<400>  19
gaaaaacaaa agcaacaaaa atgaaggcaa tactagtagt tctgctatat acatttacaa       60

ccgcaaatgc agacacatta tgtataggtt atcatgcgaa caattcaaca gacactgtag      120

acacagtact agaaaagaat gtaacagtaa cacactctgt taaccttctg gaagacaagc      180

ataacggaaa actatgcggc ggagggggct catgcaatac aacttgtcag acacccgagg      240

gtgctataaa caccagcctc ccatttcaga atatacatcc gatcacaatt ggaaaatgtc      300

caaagtatgt aaaaagcaca aaattgagac tggccacagg attgaggaat gttccgtcta      360

ttcaatctag aggcctattc ggggccattg ccggcttcat tgaagggggg tggacaggga      420

tggtagatgg atggtacggt tatcaccatc aaaatgagca ggggtcagga tatgcagccg      480

acctgaagag cacacaaaat gccattgaca agattactaa caaagtaaat tctgttattg      540

aaaagatgaa tacacagttc acagcagtgg gtaaagagtt caaccacctg gaaaaaagaa      600

tagagaatct aaataaaaaa gttgatgatg gtttcctgga catttggact tacaatgccg      660

aactgttggt tctattggaa aatgaaagaa ctttggacta tcacgattca aatgtgaaga      720

acttgtatga aaaagtaaga aaccagttaa aaaacaatgc caaggaaatt ggaaacggct      780

gctttgaatt ttaccacaaa tgcgataaca cgtgcatgga aagtgtcaaa aatgggactt      840

atgactaccc aaaatactca gaggaagcaa aattaaacag agaaaaaata gatggggtaa      900

agctggaatc aacaaggatt taccagattt tggcgatcta ttcaactgtc gccagttcat      960

tggtactggt agtctccctg ggggcaatca gcttctggat gtgctctaat gggtctctac     1020

agtgtagaat atgtatttaa attaggattt cagaatcatg agaaaaacac                1070


<210>  20
<211>  339
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA withstalk domain and 
       conservedglobular regions linked with linker (?HA/H1N1-I)

<400>  20

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Thr Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Gly Gly Gly Gly Ser 
    50                  55                  60                  


Cys Asn Thr Thr Cys Gln Thr Pro Glu Gly Ala Ile Asn Thr Ser Leu 
65                  70                  75                  80  


Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr 
                85                  90                  95      


Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro 
            100                 105                 110         


Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu 
        115                 120                 125             


Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln 
    130                 135                 140                 


Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn 
145                 150                 155                 160 


Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met 
                165                 170                 175     


Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His Leu Glu Lys 
            180                 185                 190         


Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile 
        195                 200                 205             


Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr 
    210                 215                 220                 


Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg 
225                 230                 235                 240 


Asn Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu 
                245                 250                 255     


Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly 
            260                 265                 270         


Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu 
        275                 280                 285             


Lys Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr Gln Ile Leu 
    290                 295                 300                 


Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val Val Ser Leu 
305                 310                 315                 320 


Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg 
                325                 330                 335     


Ile Cys Ile 
            


<210>  21
<211>  1361
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA with stalk domain and more globular
       regions linked with linker (?HA/H1N1-II)

<400>  21
gaaaaacaaa agcaacaaaa atgaaggcaa tactagtagt tctgctatat acatttacaa       60

ccgcaaatgc agacacatta tgtataggtt atcatgcgaa caattcaaca gacactgtag      120

acacagtact agaaaagaat gtaacagtaa cacactctgt taaccttctg gaagacaagc      180

ataacggaaa actatgcaaa ctaagagggg tagccccatt gcatttgggt aaatgtaaca      240

ttgctggctg gatcctggga aatccagagt gtgaatcact ctccacagca agttcatggt      300

cctacattgt ggaaacatct aattcagaca atggaacgtg tggcggaggg ggctcaagaa      360

tgaactatta ctggacacta gtagagccgg gagacaaaat aacattcgaa gcaactggaa      420

atctagtggt accgagatat gcattcacaa tggaaagaaa tgctggatct ggtattatca      480

tttcagatac accagtccac gattgcaata caacttgtca gacacccgag ggtgctataa      540

acaccagcct cccatttcag aatatacatc cgatcacaat tggaaaatgt ccaaagtatg      600

taaaaagcac aaaattgaga ctggccacag gattgaggaa tgttccgtct attcaatcta      660

gaggcctatt cggggccatt gccggcttca ttgaaggggg gtggacaggg atggtagatg      720

gatggtacgg ttatcaccat caaaatgagc aggggtcagg atatgcagcc gacctgaaga      780

gcacacaaaa tgccattgac aagattacta acaaagtaaa ttctgttatt gaaaagatga      840

atacacagtt cacagcagtg ggtaaagagt tcaaccacct ggaaaaaaga atagagaatc      900

taaataaaaa agttgatgat ggtttcctgg acatttggac ttacaatgcc gaactgttgg      960

ttctattgga aaatgaaaga actttggact atcacgattc aaatgtgaag aacttgtatg     1020

aaaaagtaag aaaccagtta aaaaacaatg ccaaggaaat tggaaacggc tgctttgaat     1080

tttaccacaa atgcgataac acgtgcatgg aaagtgtcaa aaatgggact tatgactacc     1140

caaaatactc agaggaagca aaattaaaca gagaaaaaat agatggggta aagctggaat     1200

caacaaggat ttaccagatt ttggcgatct attcaactgt cgccagttca ttggtactgg     1260

tagtctccct gggggcaatc agcttctgga tgtgctctaa tgggtctcta cagtgtagaa     1320

tatgtattta aattaggatt tcagaatcat gagaaaaaca c                         1361


<210>  22
<211>  436
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA with stalk domain and more globular
       regions linked with linker (?HA/H1N1-II)

<400>  22

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Thr Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Gly Gly Gly Gly Ser 
            100                 105                 110         


Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys Ile Thr 
        115                 120                 125             


Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe Thr Met 
    130                 135                 140                 


Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro Val His 
145                 150                 155                 160 


Asp Cys Asn Thr Thr Cys Gln Thr Pro Glu Gly Ala Ile Asn Thr Ser 
                165                 170                 175     


Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys Pro Lys 
            180                 185                 190         


Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val 
        195                 200                 205             


Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
    210                 215                 220                 


Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
225                 230                 235                 240 


Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln 
                245                 250                 255     


Asn Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys 
            260                 265                 270         


Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His Leu Glu 
        275                 280                 285             


Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp 
    290                 295                 300                 


Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg 
305                 310                 315                 320 


Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val 
                325                 330                 335     


Arg Asn Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe 
            340                 345                 350         


Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn 
        355                 360                 365             


Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg 
    370                 375                 380                 


Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr Gln Ile 
385                 390                 395                 400 


Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val Val Ser 
                405                 410                 415     


Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
            420                 425                 430         


Arg Ile Cys Ile 
        435     


<210>  23
<211>  1346
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA with stalk domain and more globular
       regions linked without linker (?HA/H1N1-III)

<400>  23
gaaaaacaaa agcaacaaaa atgaaggcaa tactagtagt tctgctatat acatttacaa       60

ccgcaaatgc agacacatta tgtataggtt atcatgcgaa caattcaaca gacactgtag      120

acacagtact agaaaagaat gtaacagtaa cacactctgt taaccttctg gaagacaagc      180

ataacggaaa actatgcaaa ctaagagggg tagccccatt gcatttgggt aaatgtaaca      240

ttgctggctg gatcctggga aatccagagt gtgaatcact ctccacagca agttcatggt      300

cctacattgt ggaaacatct aattcagaca atggaacgtg tagaatgaac tattactgga      360

cactagtaga gccgggagac aaaataacat tcgaagcaac tggaaatcta gtggtaccga      420

gatatgcatt cacaatggaa agaaatgctg gatctggtat tatcatttca gatacaccag      480

tccacgattg caatacaact tgtcagacac ccgagggtgc tataaacacc agcctcccat      540

ttcagaatat acatccgatc acaattggaa aatgtccaaa gtatgtaaaa agcacaaaat      600

tgagactggc cacaggattg aggaatgttc cgtctattca atctagaggc ctattcgggg      660

ccattgccgg cttcattgaa ggggggtgga cagggatggt agatggatgg tacggttatc      720

accatcaaaa tgagcagggg tcaggatatg cagccgacct gaagagcaca caaaatgcca      780

ttgacaagat tactaacaaa gtaaattctg ttattgaaaa gatgaataca cagttcacag      840

cagtgggtaa agagttcaac cacctggaaa aaagaataga gaatctaaat aaaaaagttg      900

atgatggttt cctggacatt tggacttaca atgccgaact gttggttcta ttggaaaatg      960

aaagaacttt ggactatcac gattcaaatg tgaagaactt gtatgaaaaa gtaagaaacc     1020

agttaaaaaa caatgccaag gaaattggaa acggctgctt tgaattttac cacaaatgcg     1080

ataacacgtg catggaaagt gtcaaaaatg ggacttatga ctacccaaaa tactcagagg     1140

aagcaaaatt aaacagagaa aaaatagatg gggtaaagct ggaatcaaca aggatttacc     1200

agattttggc gatctattca actgtcgcca gttcattggt actggtagtc tccctggggg     1260

caatcagctt ctggatgtgc tctaatgggt ctctacagtg tagaatatgt atttaaatta     1320

ggatttcaga atcatgagaa aaacac                                          1346


<210>  24
<211>  431
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA with stalk domain and more globular
       regions linked without linker (?HA/H1N1-III)

<400>  24

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Thr Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Arg Met Asn Tyr Tyr 
            100                 105                 110         


Trp Thr Leu Val Glu Pro Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly 
        115                 120                 125             


Asn Leu Val Val Pro Arg Tyr Ala Phe Thr Met Glu Arg Asn Ala Gly 
    130                 135                 140                 


Ser Gly Ile Ile Ile Ser Asp Thr Pro Val His Asp Cys Asn Thr Thr 
145                 150                 155                 160 


Cys Gln Thr Pro Glu Gly Ala Ile Asn Thr Ser Leu Pro Phe Gln Asn 
                165                 170                 175     


Ile His Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr Val Lys Ser Thr 
            180                 185                 190         


Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Val Pro Ser Ile Gln Ser 
        195                 200                 205             


Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr 
    210                 215                 220                 


Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly 
225                 230                 235                 240 


Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala Ile Asp Lys 
                245                 250                 255     


Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe 
            260                 265                 270         


Thr Ala Val Gly Lys Glu Phe Asn His Leu Glu Lys Arg Ile Glu Asn 
        275                 280                 285             


Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn 
    290                 295                 300                 


Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Tyr His 
305                 310                 315                 320 


Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg Asn Gln Leu Lys 
                325                 330                 335     


Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys 
            340                 345                 350         


Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr 
        355                 360                 365             


Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu Lys Ile Asp Gly 
    370                 375                 380                 


Val Lys Leu Glu Ser Thr Arg Ile Tyr Gln Ile Leu Ala Ile Tyr Ser 
385                 390                 395                 400 


Thr Val Ala Ser Ser Leu Val Leu Val Val Ser Leu Gly Ala Ile Ser 
                405                 410                 415     


Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
            420                 425                 430     


<210>  25
<211>  1080
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA withstalk domain and 
       conservedglobular regions linked with linker (?HA/H3N2-I)

<400>  25
ggataattct attaaccatg aagactatca ttgctttgag ctgcattcta tgtctggttt       60

tcgctcaaaa aattcctgga aatgacaata gcacggcaac gctgtgcctt gggcaccatg      120

cagtaccaaa cggaacgata gtgaaaacaa tcacgaatga ccgaattgaa gttactaatg      180

ctactgagct ggttcagaac tcctcaatag gtgaaatatg cggcggaggg ggctcatgca      240

agtctgaatg catcactcca aatggaagca ttccaaatga caaaccattc caaaatgtaa      300

acaggatcac atacggggca tgtcccagat atgttaagca aagcactctg aaattggcaa      360

caggaatgcg aaatgtacca gagagacaaa ctagaggcat atttggcgca atagcgggtt      420

tcatagaaaa tggttgggag ggaatggtgg atggttggta cggcttcagg catcaaaatt      480

ctgagggaag aggacaagca gcagatctta aaagcactca agcagcaatc gatcaaatca      540

atgggaagct gaatcgattg atcgggaaaa ccaacgagaa attccatcag attgaaaaag      600

agttctcaga agtagaaggg agaattcagg accttgagaa atatgttgag gacacaaaaa      660

tagatctctg gtcatacaac gcggagcttc ttgttgccct ggagaaccaa catacaattg      720

atctaactga ctcagaaatg aacaaactgt ttgaaaaaac aaagaagcaa ctgagggaaa      780

atgctgagga tatgggcaat ggttgtttca aaatatacca caaatgtgac aatgcctgca      840

tggggtcaat cagaaatgga acttatgacc acaatgtata cagggatgaa gcattaaaca      900

accggttcca gatcaaggga gttgagctga agtcagggta caaagattgg atcctatgga      960

tttcctttgc catatcatgt tttttgcttt gtgttgctct gttggggttc atcatgtggg     1020

cctgccaaaa gggcaacatt aggtgcaaca tttgcatttg agtgcattaa ttaaaaacac     1080


<210>  26
<211>  347
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA withstalk domain and 
       conservedglobular regions linked with linker (?HA/H3N2-I)

<400>  26

Met Lys Thr Ile Ile Ala Leu Ser Cys Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Gly Gly Gly Gly Ser Cys Lys Ser Glu Cys Ile Thr 
65                  70                  75                  80  


Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg 
                85                  90                  95      


Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys 
            100                 105                 110         


Leu Ala Thr Gly Met Arg Asn Val Pro Glu Arg Gln Thr Arg Gly Ile 
        115                 120                 125             


Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val 
    130                 135                 140                 


Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln 
145                 150                 155                 160 


Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly 
                165                 170                 175     


Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile 
            180                 185                 190         


Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys 
        195                 200                 205             


Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu 
    210                 215                 220                 


Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu 
225                 230                 235                 240 


Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala 
                245                 250                 255     


Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn 
            260                 265                 270         


Ala Cys Met Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asn Val Tyr 
        275                 280                 285             


Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu 
    290                 295                 300                 


Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser 
305                 310                 315                 320 


Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys 
                325                 330                 335     


Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
            340                 345         


<210>  27
<211>  1359
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA with stalk domain and more globular
       regions linked with linker (?HA/H3N2-II)

<400>  27
ggataattct attaaccatg aagactatca ttgctttgag ctgcattcta tgtctggttt       60

tcgctcaaaa aattcctgga aatgacaata gcacggcaac gctgtgcctt gggcaccatg      120

cagtaccaaa cggaacgata gtgaaaacaa tcacgaatga ccgaattgaa gttactaatg      180

ctactgagct ggttcagaac tcctcaatag gtgaaatatg cgacagtcct catcagatcc      240

ttgatggaga aaactgcaca ctaatagatg ctctattggg agaccctcag tgtgatggct      300

ttcaaaataa gaaatgggac cttttcgttg aacgaaacaa agcctacagc aactgtggcg      360

gagggggctc aagaataagc atctattgga caatagtaaa accaggagac atacttttga      420

ttaacagcac agggaatcta attgctccta ggggttactt caaaatacga agtgggaaaa      480

gctcaataat gagatcagat gcacccattg gcaagtgcaa gtctgaatgc atcactccaa      540

atggaagcat tccaaatgac aaaccattcc aaaatgtaaa caggatcaca tacggggcat      600

gtcccagata tgttaagcaa agcactctga aattggcaac aggaatgcga aatgtaccag      660

agagacaaac tagaggcata tttggcgcaa tagcgggttt catagaaaat ggttgggagg      720

gaatggtgga tggttggtac ggcttcaggc atcaaaattc tgagggaaga ggacaagcag      780

cagatcttaa aagcactcaa gcagcaatcg atcaaatcaa tgggaagctg aatcgattga      840

tcgggaaaac caacgagaaa ttccatcaga ttgaaaaaga gttctcagaa gtagaaggga      900

gaattcagga ccttgagaaa tatgttgagg acacaaaaat agatctctgg tcatacaacg      960

cggagcttct tgttgccctg gagaaccaac atacaattga tctaactgac tcagaaatga     1020

acaaactgtt tgaaaaaaca aagaagcaac tgagggaaaa tgctgaggat atgggcaatg     1080

gttgtttcaa aatataccac aaatgtgaca atgcctgcat ggggtcaatc agaaatggaa     1140

cttatgacca caatgtatac agggatgaag cattaaacaa ccggttccag atcaagggag     1200

ttgagctgaa gtcagggtac aaagattgga tcctatggat ttcctttgcc atatcatgtt     1260

ttttgctttg tgttgctctg ttggggttca tcatgtgggc ctgccaaaag ggcaacatta     1320

ggtgcaacat ttgcatttga gtgcattaat taaaaacac                            1359


<210>  28
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A virus  Other feature: Headless HA with stalk domain and more globular 
       regions linked with linker (?HA/H3N2-II)

<400>  28

Met Lys Thr Ile Ile Ala Leu Ser Cys Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Asn Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Gly Gly Gly Gly Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys 
        115                 120                 125             


Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro 
    130                 135                 140                 


Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser 
145                 150                 155                 160 


Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly 
                165                 170                 175     


Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr 
            180                 185                 190         


Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr 
        195                 200                 205             


Gly Met Arg Asn Val Pro Glu Arg Gln Thr Arg Gly Ile Phe Gly Ala 
    210                 215                 220                 


Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp 
225                 230                 235                 240 


Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp 
                245                 250                 255     


Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn 
            260                 265                 270         


Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu 
        275                 280                 285             


Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu 
    290                 295                 300                 


Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala 
305                 310                 315                 320 


Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys 
                325                 330                 335     


Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met 
            340                 345                 350         


Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Met 
        355                 360                 365             


Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asn Val Tyr Arg Asp Glu 
    370                 375                 380                 


Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly 
385                 390                 395                 400 


Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu 
                405                 410                 415     


Leu Cys Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly 
            420                 425                 430         


Asn Ile Arg Cys Asn Ile Cys Ile 
        435                 440 


<210>  29
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA with stalk domain and more globular
       regions linked without linker (?HA/H3N2-III)

<400>  29
ggataattct attaaccatg aagactatca ttgctttgag ctgcattcta tgtctggttt       60

tcgctcaaaa aattcctgga aatgacaata gcacggcaac gctgtgcctt gggcaccatg      120

cagtaccaaa cggaacgata gtgaaaacaa tcacgaatga ccgaattgaa gttactaatg      180

ctactgagct ggttcagaac tcctcaatag gtgaaatatg cgacagtcct catcagatcc      240

ttgatggaga aaactgcaca ctaatagatg ctctattggg agaccctcag tgtgatggct      300

ttcaaaataa gaaatgggac cttttcgttg aacgaaacaa agcctacagc aactgtagaa      360

taagcatcta ttggacaata gtaaaaccag gagacatact tttgattaac agcacaggga      420

atctaattgc tcctaggggt tacttcaaaa tacgaagtgg gaaaagctca ataatgagat      480

cagatgcacc cattggcaag tgcaagtctg aatgcatcac tccaaatgga agcattccaa      540

atgacaaacc attccaaaat gtaaacagga tcacatacgg ggcatgtccc agatatgtta      600

agcaaagcac tctgaaattg gcaacaggaa tgcgaaatgt accagagaga caaactagag      660

gcatatttgg cgcaatagcg ggtttcatag aaaatggttg ggagggaatg gtggatggtt      720

ggtacggctt caggcatcaa aattctgagg gaagaggaca agcagcagat cttaaaagca      780

ctcaagcagc aatcgatcaa atcaatggga agctgaatcg attgatcggg aaaaccaacg      840

agaaattcca tcagattgaa aaagagttct cagaagtaga agggagaatt caggaccttg      900

agaaatatgt tgaggacaca aaaatagatc tctggtcata caacgcggag cttcttgttg      960

ccctggagaa ccaacataca attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa     1020

aaacaaagaa gcaactgagg gaaaatgctg aggatatggg caatggttgt ttcaaaatat     1080

accacaaatg tgacaatgcc tgcatggggt caatcagaaa tggaacttat gaccacaatg     1140

tatacaggga tgaagcatta aacaaccggt tccagatcaa gggagttgag ctgaagtcag     1200

ggtacaaaga ttggatccta tggatttcct ttgccatatc atgttttttg ctttgtgttg     1260

ctctgttggg gttcatcatg tgggcctgcc aaaagggcaa cattaggtgc aacatttgca     1320

tttgagtgca ttaattaaaa acac                                            1344


<210>  30
<211>  435
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A virus-Headless HA with stalk domain and more globular
       regions linked without linker (?HA/H3N2-III)

<400>  30

Met Lys Thr Ile Ile Ala Leu Ser Cys Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Asn Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu 
        115                 120                 125             


Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys 
    130                 135                 140                 


Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly 
145                 150                 155                 160 


Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp 
                165                 170                 175     


Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg 
            180                 185                 190         


Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val 
        195                 200                 205             


Pro Glu Arg Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile 
    210                 215                 220                 


Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His 
225                 230                 235                 240 


Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln 
                245                 250                 255     


Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys 
            260                 265                 270         


Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu 
        275                 280                 285             


Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp 
    290                 295                 300                 


Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His 
305                 310                 315                 320 


Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr 
                325                 330                 335     


Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe 
            340                 345                 350         


Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Met Gly Ser Ile Arg Asn 
        355                 360                 365             


Gly Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg 
    370                 375                 380                 


Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile 
385                 390                 395                 400 


Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu 
                405                 410                 415     


Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn 
            420                 425                 430         


Ile Cys Ile 
        435 


<210>  31
<211>  1388
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/WSN/33 virus-Headless HA with stalk domain and more 
       globular regions linked with linker (?HA/WSN-II)

<400>  31
agcaaaagca ggggaaaata aaaacaacca aaatgaaggc aaaactaggc ggagggggct       60

cactggtcct gttatatgca tttgtagcta cagatgcaga cacaatatgt ataggctacc      120

atgcgaacaa ctcaaccgac actgttgaca caatattcga gaagaatgtg gcagtgacac      180

attctgttaa cctgctcgaa gacagacaca acgggaaact atgtaaatta aaaggaatag      240

ccccactaca attggggaaa tgtaacatca ccggatggct cttgggaaat ccagaatgcg      300

actcactgct tccagcgaga tcatggtcct acattgtaga aacaccaaac tctgagaatg      360

gagcatgtag gatgaactat tactggacct tgctagaacc cggagacaca ataatatttg      420

aggcaactgg taatctaata gcaccatggt atgctttcgc actgagtaga gggtttgagt      480

ccggcatcat cacctcaaac gcgtcaatgc atgagtgtaa cacgaagtgt caaacacccc      540

agggatctat aaacagcaat ctccctttcc agaatataca cccagtcaca ataggagagt      600

gcccaaaata tgtcaggagt accaaattga ggatggttac aggactaaga aacatcccat      660

ccattcaata cagaggtcta tttggagcca ttgctggttt tattgagggg ggatggactg      720

gaatgataga tggatggtat ggttatcatc atcagaatga acagggatca ggctatgcag      780

cggatcaaaa aagcacacag aatgccatta acgggattac aaacaaggtg aactctgtta      840

tcgagaaaat gaacactcaa ttcacagctg tgggtaaaga attcaacaac ttagaaaaaa      900

ggatggaaaa tttaaataaa aaagttgatg atgggtttct ggacatttgg acatataatg      960

cagaattgtt agttctactg gaaaatgaaa gaactttgga tttccatgac ttaaatgtga     1020

agaatctgta cgagaaagta aaaagccaat taaagaataa tgccaaagaa atcggaaatg     1080

ggtgttttga gttctaccac aagtgtgaca atgaatgcat ggaaagtgta agaaatggga     1140

cttatgatta tccaaaatat tcagaagaat caaagttgaa cagggaaaag atagatggag     1200

tgaaattgga atcaatgggg gtgtatcaga ttctggcgat ctactcaact gtcgccagtt     1260

cactggtgct tttggtctcc ctgggggcaa tcagtttctg gatgtgttct aatgggtctt     1320

tgcagtgcag aatatgcatc tgagattaga atttcagaga tatgaggaaa aacacccttg     1380

tttctact                                                              1388


<210>  32
<211>  436
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/WSN/33 virus-Headless HA with stalk domain and more 
       globular regions linked with linker (?HA/WSN-II)

<400>  32

Met Lys Ala Lys Leu Leu Val Leu Leu Tyr Ala Phe Val Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Ile Phe Glu Lys Asn Val Ala Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Thr Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Ser Leu Leu Pro Ala Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ala Cys Gly Gly Gly Gly Ser 
            100                 105                 110         


Arg Met Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile Ile 
        115                 120                 125             


Phe Glu Ala Thr Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala Leu 
    130                 135                 140                 


Ser Arg Gly Phe Glu Ser Gly Ile Ile Thr Ser Asn Ala Ser Met His 
145                 150                 155                 160 


Glu Cys Asn Thr Lys Cys Gln Thr Pro Gln Gly Ser Ile Asn Ser Asn 
                165                 170                 175     


Leu Pro Phe Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro Lys 
            180                 185                 190         


Tyr Val Arg Ser Thr Lys Leu Arg Met Val Thr Gly Leu Arg Asn Ile 
        195                 200                 205             


Pro Ser Ile Gln Tyr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
    210                 215                 220                 


Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His His 
225                 230                 235                 240 


Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln 
                245                 250                 255     


Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys 
            260                 265                 270         


Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Asn Leu Glu 
        275                 280                 285             


Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp 
    290                 295                 300                 


Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg 
305                 310                 315                 320 


Thr Leu Asp Phe His Asp Leu Asn Val Lys Asn Leu Tyr Glu Lys Val 
                325                 330                 335     


Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe 
            340                 345                 350         


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
        355                 360                 365             


Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg 
    370                 375                 380                 


Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Met Gly Val Tyr Gln Ile 
385                 390                 395                 400 


Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val Ser 
                405                 410                 415     


Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
            420                 425                 430         


Arg Ile Cys Ile 
        435     


<210>  33
<211>  1373
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/WSN/33 virus-Headless HA with stalk domain and more 
       globular regions linked without linker (?HA/WSN-III)

<400>  33
agcaaaagca ggggaaaata aaaacaacca aaatgaaggc aaaactactg gtcctgttat       60

atgcatttgt agctacagat gcagacacaa tatgtatagg ctaccatgcg aacaactcaa      120

ccgacactgt tgacacaata ttcgagaaga atgtggcagt gacacattct gttaacctgc      180

tcgaagacag acacaacggg aaactatgta aattaaaagg aatagcccca ctacaattgg      240

ggaaatgtaa catcaccgga tggctcttgg gaaatccaga atgcgactca ctgcttccag      300

cgagatcatg gtcctacatt gtagaaacac caaactctga gaatggagca tgtaggatga      360

actattactg gaccttgcta gaacccggag acacaataat atttgaggca actggtaatc      420

taatagcacc atggtatgct ttcgcactga gtagagggtt tgagtccggc atcatcacct      480

caaacgcgtc aatgcatgag tgtaacacga agtgtcaaac accccaggga tctataaaca      540

gcaatctccc tttccagaat atacacccag tcacaatagg agagtgccca aaatatgtca      600

ggagtaccaa attgaggatg gttacaggac taagaaacat cccatccatt caatacagag      660

gtctatttgg agccattgct ggttttattg aggggggatg gactggaatg atagatggat      720

ggtatggtta tcatcatcag aatgaacagg gatcaggcta tgcagcggat caaaaaagca      780

cacagaatgc cattaacggg attacaaaca aggtgaactc tgttatcgag aaaatgaaca      840

ctcaattcac agctgtgggt aaagaattca acaacttaga aaaaaggatg gaaaatttaa      900

ataaaaaagt tgatgatggg tttctggaca tttggacata taatgcagaa ttgttagttc      960

tactggaaaa tgaaagaact ttggatttcc atgacttaaa tgtgaagaat ctgtacgaga     1020

aagtaaaaag ccaattaaag aataatgcca aagaaatcgg aaatgggtgt tttgagttct     1080

accacaagtg tgacaatgaa tgcatggaaa gtgtaagaaa tgggacttat gattatccaa     1140

aatattcaga agaatcaaag ttgaacaggg aaaagataga tggagtgaaa ttggaatcaa     1200

tgggggtgta tcagattctg gcgatctact caactgtcgc cagttcactg gtgcttttgg     1260

tctccctggg ggcaatcagt ttctggatgt gttctaatgg gtctttgcag tgcagaatat     1320

gcatctgaga ttagaatttc agagatatga ggaaaaacac ccttgtttct act            1373


<210>  34
<211>  431
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/WSN/33 virus-Headless HA with stalk domain and more 
       globular regions linked without linker (?HA/WSN-III)

<400>  34

Met Lys Ala Lys Leu Leu Val Leu Leu Tyr Ala Phe Val Ala Thr Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Ile Phe Glu Lys Asn Val Ala Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Arg His Asn Gly Lys Leu Cys Lys Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Thr Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Ser Leu Leu Pro Ala Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ala Cys Arg Met Asn Tyr Tyr 
            100                 105                 110         


Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile Ile Phe Glu Ala Thr Gly 
        115                 120                 125             


Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala Leu Ser Arg Gly Phe Glu 
    130                 135                 140                 


Ser Gly Ile Ile Thr Ser Asn Ala Ser Met His Glu Cys Asn Thr Lys 
145                 150                 155                 160 


Cys Gln Thr Pro Gln Gly Ser Ile Asn Ser Asn Leu Pro Phe Gln Asn 
                165                 170                 175     


Ile His Pro Val Thr Ile Gly Glu Cys Pro Lys Tyr Val Arg Ser Thr 
            180                 185                 190         


Lys Leu Arg Met Val Thr Gly Leu Arg Asn Ile Pro Ser Ile Gln Tyr 
        195                 200                 205             


Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr 
    210                 215                 220                 


Gly Met Ile Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly 
225                 230                 235                 240 


Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr Gln Asn Ala Ile Asn Gly 
                245                 250                 255     


Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe 
            260                 265                 270         


Thr Ala Val Gly Lys Glu Phe Asn Asn Leu Glu Lys Arg Met Glu Asn 
        275                 280                 285             


Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn 
    290                 295                 300                 


Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Phe His 
305                 310                 315                 320 


Asp Leu Asn Val Lys Asn Leu Tyr Glu Lys Val Lys Ser Gln Leu Lys 
                325                 330                 335     


Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys 
            340                 345                 350         


Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr 
        355                 360                 365             


Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn Arg Glu Lys Ile Asp Gly 
    370                 375                 380                 


Val Lys Leu Glu Ser Met Gly Val Tyr Gln Ile Leu Ala Ile Tyr Ser 
385                 390                 395                 400 


Thr Val Ala Ser Ser Leu Val Leu Leu Val Ser Leu Gly Ala Ile Ser 
                405                 410                 415     


Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
            420                 425                 430     


<210>  35
<211>  1701
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/Michigan/45/2015 virus-Complete HA

<400>  35
atgaaggcaa tactagtagt tctgctatat acatttacaa ccgcaaatgc agacacatta       60

tgtataggtt atcatgcgaa caattcaaca gacactgtag acacagtact agaaaagaat      120

gtaacagtaa cacactctgt taaccttctg gaagacaagc ataacggaaa actatgcaaa      180

ctaagagggg tagccccatt gcatttgggt aaatgtaaca ttgctggctg gatcctggga      240

aatccagagt gtgaatcact ctccacagca agttcatggt cctacattgt ggaaacatct      300

aattcagaca atggaacgtg ttacccagga gatttcatca attatgagga gctaagagag      360

caattgagct cagtgtcatc atttgaaagg tttgagatat tccccaagac aagttcatgg      420

cccaatcatg actcgaacaa aggtgtaacg gcagcatgtc ctcacgctgg agcaaaaagc      480

ttctacaaaa acttgatatg gctagttaaa aaaggaaatt catacccaaa gcttaaccaa      540

tcctacatta atgataaagg gaaagaagtc ctcgtgctgt ggggcattca ccatccatct      600

actactgctg accaacaaag tctctatcag aatgcagatg catatgtttt tgtggggaca      660

tcaagataca gcaagaagtt caagccggaa atagcaacaa gacccaaagt gagggatcga      720

gaagggagaa tgaactatta ctggacacta gtagagccgg gagacaaaat aacattcgaa      780

gcaactggaa atctagtggt accgagatat gcattcacaa tggaaagaaa tgctggatct      840

ggtattatca tttcagatac accagtccac gattgcaata caacttgtca gacacccgag      900

ggtgctataa acaccagcct cccatttcag aatatacatc cgatcacaat tggaaaatgt      960

ccaaagtatg taaaaagcac aaaattgaga ctggccacag gattgaggaa tgttccgtct     1020

attcaatcta gaggcctatt cggggccatt gccggcttca ttgaaggggg gtggacaggg     1080

atggtagatg gatggtacgg ttatcaccat caaaatgagc aggggtcagg atatgcagcc     1140

gacctgaaga gcacacaaaa tgccattgac aagattacta acaaagtaaa ttctgttatt     1200

gaaaagatga atacacagtt cacagcagtg ggtaaagagt tcaaccacct ggaaaaaaga     1260

atagagaatc taaataaaaa agttgatgat ggtttcctgg acatttggac ttacaatgcc     1320

gaactgttgg ttctattgga aaatgaaaga actttggact atcacgattc aaatgtgaag     1380

aacttgtatg aaaaagtaag aaaccagtta aaaaacaatg ccaaggaaat tggaaacggc     1440

tgctttgaat tttaccacaa atgcgataac acgtgcatgg aaagtgtcaa aaatgggact     1500

tatgactacc caaaatactc agaggaagca aaattaaaca gagaaaaaat agatggggta     1560

aagctggaat caacaaggat ttaccagatt ttggcgatct attcaactgt cgccagttca     1620

ttggtactgg tagtctccct gggggcaatc agcttctgga tgtgctctaa tgggtctcta     1680

cagtgtagaa tatgtattta a                                               1701


<210>  36
<211>  566
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/Michigan/45/2015virus-Complete HA

<400>  36

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Thr Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Ser Asn Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asn Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Asn Gln Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Thr Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Thr Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Thr Arg Pro Lys Val Arg Asp Arg 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Thr Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Glu Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Val Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Asn Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Lys Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  37
<211>  1701
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/Kansas/14/2017 virus-Complete HA

<400>  37
atgaagacta tcattgcttt gagctgcatt ctatgtctgg ttttcgctca aaaaattcct       60

ggaaatgaca atagcacggc aacgctgtgc cttgggcacc atgcagtacc aaacggaacg      120

atagtgaaaa caatcacgaa tgaccgaatt gaagttacta atgctactga gctggttcag      180

aactcctcaa taggtgaaat atgcgacagt cctcatcaga tccttgatgg agaaaactgc      240

acactaatag atgctctatt gggagaccct cagtgtgatg gctttcaaaa taagaaatgg      300

gaccttttcg ttgaacgaaa caaagcctac agcaactgtt acccttatga tgtgccggat      360

tatgcatccc ttagatcact agttgcctca tccggcacac tggagtttaa caatgaaagc      420

ttcaattggg ctggagtcac tcaaaacgga acaagttctt cttgcataag gggatctaaa      480

agtagtttct ttagtagatt aaattggttg acccacttaa actccaaata cccagcatta      540

aacgtgacta tgccaaacaa tgaacaattt gacaaattgt acatttgggg tgttcaccac      600

ccgggtacgg acaaggacca aatctccctg tatgcacaat catcaggaag aatcacagta      660

tctaccaaaa gaagccaaca agctgtaatc ccgaatatcg gatctagacc cagaataagg      720

gatatcccta gcagaataag catctattgg acaatagtaa aaccaggaga catacttttg      780

attaacagca cagggaatct aattgctcct aggggttact tcaaaatacg aagtgggaaa      840

agctcaataa tgagatcaga tgcacccatt ggcaagtgca agtctgaatg catcactcca      900

aatggaagca ttccaaatga caaaccattc caaaatgtaa acaggatcac atacggggca      960

tgtcccagat atgttaagca aagcactctg aaattggcaa caggaatgcg aaatgtacca     1020

gagagacaaa ctagaggcat atttggcgca atagcgggtt tcatagaaaa tggttgggag     1080

ggaatggtgg atggttggta cggcttcagg catcaaaatt ctgagggaag aggacaagca     1140

gcagatctta aaagcactca agcagcaatc gatcaaatca atgggaagct gaatcgattg     1200

atcgggaaaa ccaacgagaa attccatcag attgaaaaag agttctcaga agtagaaggg     1260

agaattcagg accttgagaa atatgttgag gacacaaaaa tagatctctg gtcatacaac     1320

gcggagcttc ttgttgccct ggagaaccaa catacaattg atctaactga ctcagaaatg     1380

aacaaactgt ttgaaaaaac aaagaagcaa ctgagggaaa atgctgagga tatgggcaat     1440

ggttgtttca aaatatacca caaatgtgac aatgcctgca tggggtcaat cagaaatgga     1500

acttatgacc acaatgtata cagggatgaa gcattaaaca accggttcca gatcaaggga     1560

gttgagctga agtcagggta caaagattgg atcctatgga tttcctttgc catatcatgt     1620

tttttgcttt gtgttgctct gttggggttc atcatgtggg cctgccaaaa gggcaacatt     1680

aggtgcaaca tttgcatttg a                                               1701


<210>  38
<211>  566
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/Kansas/14/2017 virus-Complete HA

<400>  38

Met Lys Thr Ile Ile Ala Leu Ser Cys Ile Leu Cys Leu Val Phe Ala 
1               5                   10                  15      


Gln Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
            20                  25                  30          


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
        35                  40                  45              


Arg Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile 
    50                  55                  60                  


Gly Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
65                  70                  75                  80  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
                85                  90                  95      


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Asn Lys Ala Tyr Ser Asn 
            100                 105                 110         


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
        115                 120                 125             


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Ala 
    130                 135                 140                 


Gly Val Thr Gln Asn Gly Thr Ser Ser Ser Cys Ile Arg Gly Ser Lys 
145                 150                 155                 160 


Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Ser Lys 
                165                 170                 175     


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys 
            180                 185                 190         


Leu Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile 
        195                 200                 205             


Ser Leu Tyr Ala Gln Ser Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
    210                 215                 220                 


Ser Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
225                 230                 235                 240 


Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
                245                 250                 255     


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
            260                 265                 270         


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
        275                 280                 285             


Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
    290                 295                 300                 


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
305                 310                 315                 320 


Cys Pro Arg Tyr Val Lys Gln Ser Thr Leu Lys Leu Ala Thr Gly Met 
                325                 330                 335     


Arg Asn Val Pro Glu Arg Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys 
    370                 375                 380                 


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
                405                 410                 415     


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
            420                 425                 430         


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
    450                 455                 460                 


Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
465                 470                 475                 480 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Met Gly Ser 
                485                 490                 495     


Ile Arg Asn Gly Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu 
            500                 505                 510         


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
        515                 520                 525             


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
    530                 535                 540                 


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
545                 550                 555                 560 


Arg Cys Asn Ile Cys Ile 
                565     


<210>  39
<211>  1433
<212>  DNA
<213>  Artificial

<220>
<223>  Influenza A/Michigan/45/2015 virus-Neuraminidase

<400>  39
agtttaaaat gaatccaaac caaaagataa taaccattgg ttcgatctgt atgacaattg       60

gaatggctaa cttaatatta caaattggaa acataatctc aatatgggtt agccactcaa      120

ttcaaattgg aaatcaaagc cagattgaaa catgcaatca aagcgtcatt acttatgaaa      180

acaacacttg ggtaaatcag acatatgtta acatcagcaa caccaacttt gctgctggac      240

agtcagtggt ttccgtgaaa ttagcgggca attcctctct ctgccctgtt agtggatggg      300

ctatatacag taaagacaac agtgtaagaa tcggttccaa gggggatgtg tttgtcataa      360

gggaaccatt catatcatgc tctcccttgg aatgcagaac cttcttcttg actcaagggg      420

ccttgctaaa tgacaaacat tccaatggaa ccattaaaga caggagccca taccgaaccc      480

taatgagctg tcctattggt gaagttccct ctccatacaa ctcaagattt gagtcagtcg      540

cttggtcagc aagtgcttgt catgatggca tcaattggct aacaattgga atttctggcc      600

cagacagtgg ggcagtggct gtgttaaagt acaatggcat aataacagac actatcaaga      660

gttggaggaa caatatattg agaacacaag agtctgaatg tgcatgtgta aatggttctt      720

gctttaccat aatgaccgat ggaccaagtg atggacaggc ctcatacaaa atcttcagaa      780

tagaaaaggg aaagataatc aaatcagtcg aaatgaaagc ccctaattat cactatgagg      840

aatgctcctg ttaccctgat tctagtgaaa tcacatgtgt gtgcagggat aactggcatg      900

gctcgaatcg accgtgggtg tctttcaacc agaatctgga atatcagatg ggatacatat      960

gcagtggggt tttcggagac aatccacgcc ctaatgataa gacaggcagt tgtggtccag     1020

tatcgtctaa tggagcaaat ggagtaaaag gattttcatt caaatacggc aatggtgttt     1080

ggatagggag aactaaaagc attagttcaa gaaaaggttt tgagatgatt tgggatccga     1140

atggatggac tgggactgac aataaattct caataaagca agatatcgta ggaataaatg     1200

agtggtcagg gtatagcggg agttttgttc agcatccaga actaacaggg ctggattgta     1260

taagaccttg cttctgggtt gaactaataa gagggcgacc cgaagagaac acaatctgga     1320

ctagcgggag cagcatatcc ttttgtggtg taaacagtga cactgtgggt tggtcttggc     1380

cagacggtgc tgagttgcca tttaccattg acaagtaatt tgttcaaaaa act            1433


<210>  40
<211>  469
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/Michigan/45/2015 virus Other feature:Neuraminidase

<400>  40

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Thr 
1               5                   10                  15      


Ile Gly Met Ala Asn Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile Gln Ile Gly Asn Gln Ser Gln Ile Glu Thr 
        35                  40                  45              


Cys Asn Gln Ser Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln 
    50                  55                  60                  


Thr Tyr Val Asn Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val 
65                  70                  75                  80  


Val Ser Val Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser 
145                 150                 155                 160 


Cys Pro Ile Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Arg Ile Glu Lys Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro 
            260                 265                 270         


Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile 
        275                 280                 285             


Thr Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly 
                325                 330                 335     


Pro Val Ser Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys 
            340                 345                 350         


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg 
        355                 360                 365             


Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp 
    370                 375                 380                 


Asn Lys Phe Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu 
            420                 425                 430         


Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val 
        435                 440                 445             


Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
    450                 455                 460                 


Phe Thr Ile Asp Lys 
465                 


<210>  41
<211>  1441
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/Kansas/14/2017 virus Other feature:Neuraminidase

<400>  41
agtaaagatg aatccaaatc aaaagataat aacgattggc tctgtttctc tcaccatttc       60

cacaatatgc ttcttcatgc aaattgccat cctgataact actgtaacat tgcatttcaa      120

gcaatatgaa ttcaactccc ccccaaacaa ccaagtgatg ctgtgtgaac caacaataat      180

agaaagaaac ataacagaga tagtgtattt gaccaacacc accatagaga gggaaatatg      240

ccccaaacca gcagaataca gaaattggtc aaaaccgcaa tgtggcatta caggatttgc      300

acctttctct aaggacaatt cgattaggct ttccgctggt ggggacatct gggtgacaag      360

agaaccttat gtgtcatgcg atcctgacaa gtgttatcaa tttgcccttg gacagggaac      420

aacaataaac aacgtgcatt caaataacac agcacgtgat aggacccctc atcggactct      480

attgatgaat gagttgggtg ttcctttcca tctggggacc aagcaagtgt gcatagcatg      540

gtccagctca agttgtcacg atggaaaagc atggctgcat gtttgtataa cgggggatga      600

taaaaatgca actgctagtt tcatttacaa tgggaggctt gtagatagtg ttgtttcatg      660

gtccaaagat attctcagga cccaggagtc agaatgcgtt tgtatcaatg gaacttgtac      720

agtagtaatg actgatggaa atgctacagg aaaagctgat actaaaatat tattcattga      780

ggaggggaaa atcgttcata ctagcaaatt gtcaggaagt gctcagcatg tcgaagagtg      840

ctcttgctat cctcgatacc ctggtgtcag atgtgtctgc agagacaact ggaaaggatc      900

caaccggccc atcgtagata taaacataaa ggatcatagc attgtttcca gttatgtgtg      960

ttcaggactt gttggagaca cacccagaaa aaccgacagc tccagcagca gccattgctt     1020

gaatcctaac aatgaaaaag gtggtcatgg agtgaaaggc tgggcctttg atgatggaaa     1080

tgacgtgtgg atggggagaa caatcaacga gacgtcacgc ttagggtatg aaaccttcaa     1140

agtcgttgaa ggctggtcca accctaagtc caaattgcag ataaataggc aagtcatagt     1200

tgacagaggt gataggtccg gttattctgg tattttctct gttgaaggca aaagctgcat     1260

caatcggtgc ttttatgtgg agttgattag gggaagaaaa gaggaaactg aagtcttgtg     1320

gacctcaaac agtattgttg tgttttgtgg cacctcaggt acatatggaa caggctcatg     1380

gcctgatggg gcggacctca atctcatgca tatataagct ttcgcaattt tagaaaaaac     1440

t                                                                     1441


<210>  42
<211>  469
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/Kansas/14/2017 virusOther feature:Neuraminidase

<400>  42

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Ile Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Arg Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Pro Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gly Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Ile Asn Asn Val His 
    130                 135                 140                 


Ser Asn Asn Thr Ala Arg Asp Arg Thr Pro His Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Val Val Ser Trp Ser Lys Asp Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Asn Ala Thr Gly Lys Ala Asp Thr Lys Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Thr Ser Lys Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp 
    290                 295                 300                 


Ile Asn Ile Lys Asp His Ser Ile Val Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Lys Thr Asp Ser Ser Ser Ser Ser His 
                325                 330                 335     


Cys Leu Asn Pro Asn Asn Glu Lys Gly Gly His Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Asn Glu 
        355                 360                 365             


Thr Ser Arg Leu Gly Tyr Glu Thr Phe Lys Val Val Glu Gly Trp Ser 
    370                 375                 380                 


Asn Pro Lys Ser Lys Leu Gln Ile Asn Arg Gln Val Ile Val Asp Arg 
385                 390                 395                 400 


Gly Asp Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu 
            420                 425                 430         


Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Leu 
    450                 455                 460                 


Asn Leu Met His Ile 
465                 


<210>  43
<211>  2341
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:Polymerase basic protein 1 (PB1)

<400>  43
agcgaaagca ggcaaaccat ttgaatggat gtcaatccga ccttactttt cttaaaagtg       60

ccaacacaaa atgctataag cacaactttc ccttatactg gagaccctcc ttacagccat      120

gggacaggaa caggatacac catggatact gtcaacagga cacatcagta ctcagaaaag      180

ggaagatgga caacaaacac cgaaactgga gcaccgcaac tcaacccgat tgatgggcca      240

ctgccagaag acaatgaacc aagtggttat gcccaaacag attgtgtatt ggaggcgatg      300

gctttccttg aggaatccca tcctggtatt tttgaaaact cgtgtattga aacgatggag      360

gttgttcagc aaacacgagt agacaagctg acacaaggcc gacagaccta tgactggact      420

ctaaatagaa accaacctgc tgcaacagca ttggccaaca caatagaagt gttcagatca      480

aatggcctca cggccaatga gtctggaagg ctcatagact tccttaagga tgtaatggag      540

tcaatgaaca aagaagaaat ggggatcaca actcattttc agagaaagag acgggtgaga      600

gacaatatga ctaagaaaat gataacacag agaacaatgg gtaaaaagaa gcagagattg      660

aacaaaagga gttatctaat tagagcattg accctgaaca caatgaccaa agatgctgag      720

agagggaagc taaaacggag agcaattgca accccaggga tgcaaataag ggggtttgta      780

tactttgttg agacactggc aaggagtata tgtgagaaac ttgaacaatc agggttgcca      840

gttggaggca atgagaagaa agcaaagttg gcaaatgttg taaggaagat gatgaccaat      900

tctcaggaca ccgaactttc tttcaccatc actggagata acaccaaatg gaacgaaaat      960

cagaatcctc ggatgttttt ggccatgatc acatatatga ccagaaatca gcccgaatgg     1020

ttcagaaatg ttctaagtat tgctccaata atgttctcaa acaaaatggc gagactggga     1080

aaagggtata tgtttgagag caagagtatg aaacttagaa ctcaaatacc tgcagaaatg     1140

ctagcaagca tcgatttgaa atatttcaat gattcaacaa gaaagaagat tgaaaaaatc     1200

cgaccgctct taatagaggg gactgcatca ttgagccctg gaatgatgat gggcatgttc     1260

aatatgttaa gcactgtatt aggcgtctcc atcctgaatc ttggacaaaa gagatacacc     1320

aagactactt actggtggga tggtcttcaa tcctctgacg attttgctct gattgtgaat     1380

gcacccaatc atgaagggat tcaagccgga gtcgacaggt tttatcgaac ctgtaagcta     1440

cttggaatca atatgagcaa gaaaaagtct tacataaaca gaacaggtac atttgaattc     1500

acaagttttt tctatcgtta tgggtttgtt gccaatttca gcatggagct tcccagtttt     1560

ggggtgtctg ggatcaacga gtcagcggac atgagtattg gagttactgt catcaaaaac     1620

aatatgataa acaatgatct tggtccagca acagctcaaa tggcccttca gttgttcatc     1680

aaagattaca ggtacacgta ccgatgccat agaggtgaca cacaaataca aacccgaaga     1740

tcatttgaaa taaagaaact gtgggagcaa acccgttcca aagctggact gctggtctcc     1800

gacggaggcc caaatttata caacattaga aatctccaca ttcctgaagt ctgcctaaaa     1860

tgggaattga tggatgagga ttaccagggg cgtttatgca acccactgaa cccatttgtc     1920

agccataaag aaattgaatc aatgaacaat gcagtgatga tgccagcaca tggtccagcc     1980

aaaaacatgg agtatgatgc tgttgcaaca acacactcct ggatccccaa aagaaatcga     2040

tccatcttga atacaagtca aagaggagta cttgaggatg aacaaatgta ccaaaggtgc     2100

tgcaatttat ttgaaaaatt cttccccagc agttcataca gaagaccagt cgggatatcc     2160

agtatggtgg aggctatggt ttccagagcc cgaattgatg cacggattga tttcgaatct     2220

ggaaggataa agaaagaaga gttcactgag atcatgaaga tctgttccac cattgaagag     2280

ctcagacggc aaaaatagtg aatttagctt gtccttcatg aaaaaatgcc ttgtttctac     2340

t                                                                     2341


<210>  44
<211>  757
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:Polymerase basic protein 1 (PB1)

<400>  44

Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Val Pro Ala Gln Asn 
1               5                   10                  15      


Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          


Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              


Tyr Ser Glu Lys Gly Arg Trp Thr Thr Asn Thr Glu Thr Gly Ala Pro 
    50                  55                  60                  


Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  


Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      


Glu Ser His Pro Gly Ile Phe Glu Asn Ser Cys Ile Glu Thr Met Glu 
            100                 105                 110         


Val Val Gln Gln Thr Arg Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             


Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 


Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 


Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Met Glu Ser Met Asn Lys 
                165                 170                 175     


Glu Glu Met Gly Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         


Asp Asn Met Thr Lys Lys Met Ile Thr Gln Arg Thr Met Gly Lys Lys 
        195                 200                 205             


Lys Gln Arg Leu Asn Lys Arg Ser Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 


Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 


Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     


Thr Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         


Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             


Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 


Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala 
305                 310                 315                 320 


Met Ile Thr Tyr Met Thr Arg Asn Gln Pro Glu Trp Phe Arg Asn Val 
                325                 330                 335     


Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         


Lys Gly Tyr Met Phe Glu Ser Lys Ser Met Lys Leu Arg Thr Gln Ile 
        355                 360                 365             


Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Asp Ser 
    370                 375                 380                 


Thr Arg Lys Lys Ile Glu Lys Ile Arg Ser Leu Leu Ile Glu Gly Thr 
385                 390                 395                 400 


Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     


Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Arg Tyr Thr 
            420                 425                 430         


Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             


Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 


Arg Phe Tyr Arg Thr Cys Lys Leu Leu Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 


Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     


Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         


Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             


Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 


Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 


Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Ile 
                565                 570                 575     


Lys Lys Leu Trp Glu Gln Thr Arg Ser Lys Ala Gly Leu Leu Val Ser 
            580                 585                 590         


Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             


Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Gln Gly Arg Leu 
    610                 615                 620                 


Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Ile Glu Ser Met 
625                 630                 635                 640 


Asn Asn Ala Val Met Met Pro Ala His Gly Pro Ala Lys Asn Met Glu 
                645                 650                 655     


Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         


Ser Ile Leu Asn Thr Ser Gln Arg Gly Val Leu Glu Asp Glu Gln Met 
        675                 680                 685             


Tyr Gln Arg Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 


Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 


Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     


Lys Glu Glu Phe Thr Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         


Leu Arg Arg Gln Lys 
        755         


<210>  45
<211>  2341
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:Polymerase basic protein 2 (PB2)

<400>  45
agcgaaagca ggtcaattat attcaatatg gaaagaataa aagaactaag aaatctaatg       60

tcgcagtctc gcacccgcga gatactcaca aaaaccaccg tggaccatat ggccataatc      120

aagaagtaca catcaggaag acaggagaag aacccagcac ttaggatgaa atggatgatg      180

gcaatgaaat atccaattac agcagacaag aggataacgg aaatgattcc tgagagaaat      240

gagcaaggac aaactttatg gagtaaaatg aatgatgccg gatcagaccg agtgatggta      300

tcacctctgg ctgtgacatg gtggaatagg aatggaccaa tgacaaatac agttcattat      360

ccaaaaatct acaaaactta ttttgaaaga gtcgaaaggc taaagcatgg aacctttggc      420

cctgtccatt ttagaaacca agtcaaaata cgtcggagag ttgacataaa tcctggtcat      480

gcagatctca gtgccaagga ggcacaggat gtaatcatgg aagttgtttt ccctaacgaa      540

gtgggagcca ggatactaac atcggaatcg caactaacga taaccaaaga gaagaaagaa      600

gaactccagg attgcaaaat ttctcctttg atggttgcat acatgttgga gagagaactg      660

gtccgcaaaa cgagattcct cccagtggct ggtggaacaa gcagtgtgta cattgaagtg      720

ttgcatttga ctcaaggaac atgctgggaa cagatgtata ctccaggagg ggaagtgaag      780

aatgatgatg ttgatcaaag cttgattatt gctgctagga acatagtgag aagagctgca      840

gtatcagcag acccactagc atctttattg gagatgtgcc acagcacaca gattggtgga      900

attaggatgg tagacatcct taagcagaac ccaacagaag agcaagccgt gggtatatgc      960

aaggctgcaa tgggactgag aattagctca tccttcagtt ttggtggatt cacatttaag     1020

agaacaagcg gatcatcagt caagagagag gaagaggtgc ttacgggcaa tcttcaaaca     1080

ttgaagataa gagtgcatga gggatatgaa gagttcacaa tggttgggag aagagcaaca     1140

gccatactca gaaaagcaac caggagattg attcagctga tagtgagtgg gagagacgaa     1200

cagtcgattg ccgaagcaat aattgtggcc atggtatttt cacaagagga ttgtatgata     1260

aaagcagtta gaggtgatct gaatttcgtc aatagggcga atcagcgact gaatcctatg     1320

catcaacttt taagacattt tcagaaggat gcgaaagtgc tttttcaaaa ttggggagtt     1380

gaacctatcg acaatgtgat gggaatgatt gggatattgc ccgacatgac tccaagcatc     1440

gagatgtcaa tgagaggagt gagaatcagc aaaatgggtg tagatgagta ctccagcacg     1500

gagagggtag tggtgagcat tgaccggttc ttgagagtcc gggaccaacg aggaaatgta     1560

ctactgtctc ccgaggaggt cagtgaaaca cagggaacag agaaactgac aataacttac     1620

tcatcgtcaa tgatgtggga gattaatggt cctgaatcag tgttggtcaa tacctatcaa     1680

tggatcatca gaaactggga aactgttaaa attcagtggt cccagaaccc tacaatgcta     1740

tacaataaaa tggaatttga accatttcag tctttagtac ctaaggccat tagaggccaa     1800

tacagtgggt ttgtgagaac tctgttccaa caaatgaggg atgtgcttgg gacatttgat     1860

accgcacaga taataaaact tcttcccttc gcagccgctc caccaaagca aagtagaatg     1920

cagttctcct catttactgt gaatgtgagg ggatcaggaa tgagaatact tgtaaggggc     1980

aattctcctg tattcaacta caacaaggcc acgaagagac tcacagttct cggaaaggat     2040

gctggcactt taaccgaaga cccagatgaa ggcacagctg gagtggagtc cgctgttctg     2100

aggggattcc tcattctggg caaagaagac aggagatatg ggccagcatt aagcatcaat     2160

gaactgagca accttgcgaa aggagagaag gctaatgtgc taattgggca aggagacgtg     2220

gtgttggtaa tgaaacgaaa acgggactct agcatactta ctgacagcca gacagcgacc     2280

aaaagaattc ggatggccat caattagtgt cgaatagttt aaaaacgacc ttgtttctac     2340

t                                                                     2341


<210>  46
<211>  759
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:Polymerase basic protein 2 (PB2)

<400>  46

Met Glu Arg Ile Lys Glu Leu Arg Asn Leu Met Ser Gln Ser Arg Thr 
1               5                   10                  15      


Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          


Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 
        35                  40                  45              


Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Thr 
    50                  55                  60                  


Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 
65                  70                  75                  80  


Met Asn Asp Ala Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      


Thr Trp Trp Asn Arg Asn Gly Pro Ile Thr Asn Thr Val His Tyr Pro 
            100                 105                 110         


Lys Ile Tyr Lys Thr Tyr Phe Glu Arg Val Glu Arg Leu Lys His Gly 
        115                 120                 125             


Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 
    130                 135                 140                 


Val Asp Ile Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 
145                 150                 155                 160 


Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 
                165                 170                 175     


Leu Thr Ser Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Lys Glu Glu 
            180                 185                 190         


Leu Gln Asp Cys Lys Ile Ser Pro Leu Met Val Ala Tyr Met Leu Glu 
        195                 200                 205             


Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 
    210                 215                 220                 


Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 
225                 230                 235                 240 


Glu Gln Met Tyr Thr Pro Gly Gly Glu Val Arg Asn Asp Asp Val Asp 
                245                 250                 255     


Gln Ser Leu Ile Ile Ala Ala Arg Asn Ile Val Arg Arg Ala Ala Val 
            260                 265                 270         


Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 
        275                 280                 285             


Ile Gly Gly Ile Arg Met Val Asp Ile Leu Arg Gln Asn Pro Thr Glu 
    290                 295                 300                 


Glu Gln Ala Val Asp Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 
305                 310                 315                 320 


Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 
                325                 330                 335     


Ser Val Lys Arg Glu Glu Glu Val Leu Thr Gly Asn Leu Gln Thr Leu 
            340                 345                 350         


Lys Ile Arg Val His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg 
        355                 360                 365             


Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 
    370                 375                 380                 


Ile Val Ser Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 
385                 390                 395                 400 


Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 
                405                 410                 415     


Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 
            420                 425                 430         


Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 
        435                 440                 445             


Trp Gly Val Glu Pro Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu 
    450                 455                 460                 


Pro Asp Met Thr Pro Ser Ile Glu Met Ser Met Arg Gly Val Arg Ile 
465                 470                 475                 480 


Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Thr Glu Arg Val Val Val 
                485                 490                 495     


Ser Ile Asp Arg Phe Leu Arg Ile Arg Asp Gln Arg Gly Asn Val Leu 
            500                 505                 510         


Leu Ser Pro Glu Glu Val Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 
        515                 520                 525             


Ile Thr Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 
    530                 535                 540                 


Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Thr Val 
545                 550                 555                 560 


Lys Ile Gln Trp Ser Gln Asn Pro Thr Met Leu Tyr Asn Lys Met Glu 
                565                 570                 575     


Phe Glu Pro Phe Gln Ser Leu Val Pro Lys Ala Ile Arg Gly Gln Tyr 
            580                 585                 590         


Ser Gly Phe Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly 
        595                 600                 605             


Thr Phe Asp Thr Ala Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 
    610                 615                 620                 


Pro Pro Lys Gln Ser Arg Met Gln Phe Ser Ser Phe Thr Val Asn Val 
625                 630                 635                 640 


Arg Gly Ser Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Val Phe 
                645                 650                 655     


Asn Tyr Asn Lys Ala Thr Lys Arg Leu Thr Val Leu Gly Lys Asp Ala 
            660                 665                 670         


Gly Thr Leu Thr Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser 
        675                 680                 685             


Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asn Lys Arg Tyr 
    690                 695                 700                 


Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Asn Leu Ala Lys Gly Glu 
705                 710                 715                 720 


Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 
                725                 730                 735     


Arg Lys Arg Asp Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 
            740                 745                 750         


Arg Ile Arg Met Ala Ile Asn 
        755                 


<210>  47
<211>  2233
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:polymerase acid protein (PA)

<400>  47
agcgaaagca ggtactgatc caaaatggaa gattttgtgc gacaatgctt caatccgatg       60

attgtcgagc ttgcggaaaa aacaatgaaa gagtatgggg aggacctgaa aatcgaaaca      120

aacaaatttg cagcaatatg cactcacttg gaagtatgct tcatgtattc agatttccac      180

ttcatcaatg agcaaggcga gtcaataatc gtagaacttg gtgatcctaa tgcacttttg      240

aagcacagat ttgaaataat cgagggaaga gatcgcacaa tggcctggac agtagtaaac      300

agtatttgca acactacagg ggctgagaaa ccaaagtttc taccagattt gtatgattac      360

aaggaaaata gattcatcga aattggagta acaaggagag aagttcacat atactatctg      420

gaaaaggcca ataaaattaa atctgagaaa acacacatcc acattttctc gttcactggg      480

gaagaaatgg ccacaaaggc cgactacact ctcgatgaag aaagcagggc taggatcaaa      540

accaggctat tcaccataag acaagaaatg gccagcagag gcctctggga ttcctttcgt      600

cagtccgaga gaggagaaga gacaattgaa gaaaggtttg aaatcacagg aacaatgcgc      660

aagcttgccg accaaagtct cccgccgaac ttctccagcc ttgaaaattt tagagcctat      720

gtggatggat tcgaaccgaa cggctacatt gagggcaagc tgtctcaaat gtccaaagaa      780

gtaaatgcta gaattgaacc ttttttgaaa acaacaccac gaccacttag acttccgaat      840

gggcctccct gttctcagcg gtccaaattc ctgctgatgg atgccttaaa attaagcatt      900

gaggacccaa gtcatgaagg agagggaata ccgctatatg atgcaatcaa atgcatgaga      960

acattctttg gatggaagga acccaatgtt gttaaaccac acgaaaaggg aataaatcca     1020

aattatcttc tgtcatggaa gcaagtactg gcagaactgc aggacattga gaatgaggag     1080

aaaattccaa agactaaaaa tatgaaaaaa acaagtcagc taaagtgggc acttggtgag     1140

aacatggcac cagaaaaggt agactttgac gactgtaaag atgtaggtga tttgaagcaa     1200

tatgatagtg atgaaccaga attgaggtcg cttgcaagtt ggattcagaa tgagttcaac     1260

aaggcatgcg aactgacaga ttcaagctgg atagagcttg atgagattgg agaagatgtg     1320

gctccaattg aacacattgc aagcatgaga aggaattatt tcacatcaga ggtgtctcac     1380

tgcagagcca cagaatacat aatgaagggg gtgtacatca atactgcctt acttaatgca     1440

tcttgtgcag caatggatga tttccaatta attccaatga taagcaagtg tagaactaag     1500

gagggaaggc gaaagaccaa cttgtatggt ttcatcataa aaggaagatc ccacttaagg     1560

aatgacaccg acgtggtaaa ctttgtgagc atggagtttt ctctcactga cccaagactt     1620

gaaccacaca aatgggagaa gtactgtgtt cttgagatag gagatatgct tctaagaagt     1680

gccataggcc aggtttcaag gcccatgttc ttgtatgtga ggacaaatgg aacctcaaaa     1740

attaaaatga aatggggaat ggagatgagg cgttgtctcc tccagtcact tcaacaaatt     1800

gagagtatga ttgaagctga gtcctctgtc aaagagaaag acatgaccaa agagttcttt     1860

gagaacaaat cagaaacatg gcccattgga gagtctccca aaggagtgga ggaaagttcc     1920

attgggaagg tctgcaggac tttattagca aagtcggtat ttaacagctt gtatgcatct     1980

ccacaactag aaggattttc agctgaatca agaaaactgc ttcttatcgt tcaggctctt     2040

agggacaatc tggaacctgg gacctttgat cttggggggc tatatgaagc aattgaggag     2100

tgcctaatta atgatccctg ggttttgctt aatgcttctt ggttcaactc cttccttaca     2160

catgcattga gttagttgtg gcagtgctac tatttgctat ccatactgtc caaaaaagta     2220

ccttgtttct act                                                        2233


<210>  48
<211>  716
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:polymerase acid protein (PA)

<400>  48

Met Glu Glu Phe Val Arg Gln Cys Phe Asn Pro Met Ile Val Glu Leu 
1               5                   10                  15      


Ala Glu Lys Thr Met Lys Glu Tyr Gly Glu Asp Pro Lys Ile Glu Thr 
            20                  25                  30          


Asn Lys Phe Ala Ala Ile Cys Thr His Leu Glu Val Cys Phe Met Tyr 
        35                  40                  45              


Ser Asp Phe His Phe Ile Asp Glu Arg Gly Glu Ser Lys Ile Val Glu 
    50                  55                  60                  


Ser Gly Asp Pro Asn Ala Leu Leu Lys His Arg Phe Glu Ile Ile Glu 
65                  70                  75                  80  


Gly Arg Asp Arg Thr Met Ala Trp Thr Val Val Asn Ser Ile Cys Asn 
                85                  90                  95      


Thr Thr Gly Val Glu Lys Pro Lys Phe Leu Pro Asp Leu Tyr Asp Tyr 
            100                 105                 110         


Lys Glu Asn Arg Phe Ile Glu Ile Gly Val Thr Arg Arg Glu Val His 
        115                 120                 125             


Ile Tyr Tyr Leu Glu Lys Ala Asn Lys Ile Lys Ser Glu Lys Thr His 
    130                 135                 140                 


Ile His Ile Phe Ser Phe Thr Gly Glu Glu Met Ala Thr Lys Ala Asp 
145                 150                 155                 160 


Tyr Thr Leu Asp Glu Glu Ser Arg Ala Arg Ile Lys Thr Arg Leu Phe 
                165                 170                 175     


Thr Ile Arg Gln Glu Met Ala Ser Arg Gly Leu Trp Asp Ser Phe Arg 
            180                 185                 190         


Gln Ser Glu Arg Gly Glu Glu Thr Ile Glu Glu Arg Phe Glu Ile Thr 
        195                 200                 205             


Gly Thr Met Arg Arg Leu Ala Glu Gln Ser Leu Pro Pro Asn Phe Ser 
    210                 215                 220                 


Ser Leu Glu Asn Phe Arg Ala Tyr Val Asp Gly Phe Lys Pro Asn Gly 
225                 230                 235                 240 


Cys Ile Glu Gly Lys Leu Ser Gln Met Ser Lys Glu Val Asn Ala Arg 
                245                 250                 255     


Ile Glu Pro Phe Leu Lys Thr Thr Pro Arg Pro Leu Arg Leu Pro Asp 
            260                 265                 270         


Gly Pro Pro Cys Ser Gln Arg Ser Lys Phe Leu Leu Met Asp Ala Leu 
        275                 280                 285             


Lys Leu Ser Ile Glu Asp Pro Ser His Glu Gly Glu Gly Ile Pro Leu 
    290                 295                 300                 


His Asp Ala Ile Lys Cys Met Lys Thr Phe Phe Gly Trp Lys Glu Pro 
305                 310                 315                 320 


Asn Ile Val Lys Pro His Glu Lys Gly Ile Asn Pro Asn Tyr Leu Leu 
                325                 330                 335     


Ala Trp Asn Gln Val Leu Ala Glu Leu Lys Asp Ile Glu Asn Glu Glu 
            340                 345                 350         


Lys Ile Pro Lys Thr Lys Asn Met Lys Lys Thr Ser Gln Leu Lys Trp 
        355                 360                 365             


Ala Leu Gly Glu Asn Met Ala Pro Glu Lys Val Asp Phe Glu Asp Cys 
    370                 375                 380                 


Lys Asp Ile Ser Asp Leu Lys Gln Tyr Asp Ser Asp Glu Pro Glu Gln 
385                 390                 395                 400 


Arg Ser Leu Ala Ser Trp Ile Gln Ser Glu Phe Asn Lys Ala Cys Glu 
                405                 410                 415     


Leu Thr Asp Ser Gly Trp Ile Glu Leu Asp Glu Ile Gly Glu Asp Val 
            420                 425                 430         


Ala Pro Ile Glu His Ile Ala Ser Met Arg Arg Asn Tyr Phe Thr Ala 
        435                 440                 445             


Glu Val Ser His Cys Arg Ala Thr Glu Tyr Ile Met Lys Gly Val Tyr 
    450                 455                 460                 


Ile Asn Thr Ala Leu Leu Asn Ala Ser Cys Ala Ala Met Asp Asp Phe 
465                 470                 475                 480 


Gln Leu Ile Pro Met Ile Ser Lys Cys Arg Thr Lys Glu Gly Arg Arg 
                485                 490                 495     


Lys Thr Asn Leu Tyr Gly Phe Ile Ile Lys Gly Arg Ser His Leu Arg 
            500                 505                 510         


Asn Asp Thr Asp Val Val Asn Phe Val Ser Met Glu Phe Ser Leu Thr 
        515                 520                 525             


Asp Pro Arg Leu Glu Pro His Lys Trp Glu Lys Tyr Cys Val Leu Glu 
    530                 535                 540                 


Ile Gly Asp Met Leu Leu Arg Thr Ala Ile Gly Gln Val Ser Arg Pro 
545                 550                 555                 560 


Met Phe Leu Tyr Val Arg Thr Asn Gly Thr Ser Lys Ile Lys Met Lys 
                565                 570                 575     


Trp Gly Met Glu Met Arg Arg Cys Leu Leu Gln Ser Leu Gln Gln Val 
            580                 585                 590         


Glu Ser Met Val Glu Ala Glu Ser Ser Val Lys Glu Lys Asp Met Thr 
        595                 600                 605             


Lys Glu Phe Phe Glu Asn Lys Ser Lys Thr Trp Pro Ile Gly Glu Ser 
    610                 615                 620                 


Pro Lys Gly Val Glu Glu Gly Ser Ile Gly Lys Val Cys Arg Thr Leu 
625                 630                 635                 640 


Leu Ala Lys Ser Val Phe Asn Ser Leu Tyr Ala Ser Pro Gln Leu Glu 
                645                 650                 655     


Gly Phe Ser Ala Glu Ser Arg Lys Leu Leu Leu Ile Val Gln Ala Leu 
            660                 665                 670         


Arg Asp Asn Leu Glu Pro Gly Thr Phe Asp Leu Gly Gly Leu Tyr Gly 
        675                 680                 685             


Ala Ile Glu Glu Cys Leu Ile Asn Asp Pro Trp Val Leu Leu Asn Ala 
    690                 695                 700                 


Ser Trp Phe Asn Ser Phe Leu Thr His Ala Leu Lys 
705                 710                 715     


<210>  49
<211>  1540
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:Nucleoprotein (NP)

<400>  49
gtagataatc actcactgag tgacatcaaa atcatggcgt cccaaggcac caaacggtct       60

tacgaacaga tggagactga tggagaacgc cagaatgcca ctgaaatcag agcatccgtc      120

ggaaaaatga ttggtggaat tggacgattc tacatccaaa tgtgcaccga actcaaactc      180

agtgattatg agggacggtt gatccaaaac agcttaacaa tagagagaat ggtgctctct      240

gcttttgacg aaaggagaaa taaatacctg gaagaacatc ccagtgcggg gaaagatcct      300

aagaaaactg gaggacctat atacaggaga gtaaacggaa agtggatgag agaactcatc      360

ctttatgaca aagaagaaat aaggcgaatc tggcgccaag ctaataatgg tgacgatgca      420

acggctggtc tgactcacat gatgatctgg cattccaatt tgaatgatgc aacttatcag      480

aggacaagag ctcttgttcg caccggaatg gatcccagga tgtgctctct gatgcaaggt      540

tcaactctcc ctaggaggtc tggagccgca ggtgctgcag tcaaaggagt tggaacaatg      600

gtgatggaat tggtcaggat gatcaaacgt gggatcaatg atcggaactt ctggaggggt      660

gagaatggac gaaaaacaag aattgcttat gaaagaatgt gcaacattct caaagggaaa      720

tttcaaactg ctgcacaaaa agcaatgatg gatcaagtga gagagagccg gaacccaggg      780

aatgctgagt tcgaagatct cacttttcta gcacggtctg cactcatatt gagagggtcg      840

gttgctcaca agtcctgcct gcctgcctgt gtgtatggac ctgccgtagc cagtgggtac      900

gactttgaaa gagagggata ctctctagtc ggaatagacc ctttcagact gcttcaaaac      960

agccaagtgt acagcctaat cagaccaaat gagaatccag cacacaagag tcaactggtg     1020

tggatggcat gccattctgc cgcatttgaa gatctaagag tattaagctt catcaaaggg     1080

acgaaggtgc tcccaagagg gaagctttcc actagaggag ttcaaattgc ttccaatgaa     1140

aatatggaga ctatggaatc aagtacactt gaactgagaa gcaggtactg ggccataagg     1200

accagaagtg gaggaaacac caatcaacag agggcatctg cgggccaaat cagcatacaa     1260

cctacgttct cagtacagag aaatctccct tttgacagaa caaccattat ggcagcattc     1320

aatgggaata cagagggaag aacatctgac atgaggaccg aaatcataag gatgatggaa     1380

agtgcaagac cagaagatgt gtctttccag gggcggggag tcttcgagct ctcggacgaa     1440

aaggcagcga gcccgatcgt gccttccttt gacatgagta atgaaggatc ttatttcttc     1500

ggagacaatg cagaggagta cgacaattaa agaaaaatac                           1540


<210>  50
<211>  498
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:Nucleoprotein (NP)

<400>  50

Met Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Asp 
1               5                   10                  15      


Gly Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Lys Met 
            20                  25                  30          


Ile Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys 
        35                  40                  45              


Leu Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Leu Thr Ile Glu 
    50                  55                  60                  


Arg Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Lys Tyr Leu Glu 
65                  70                  75                  80  


Glu His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile 
                85                  90                  95      


Tyr Arg Arg Val Asn Gly Lys Trp Met Arg Glu Leu Ile Leu Tyr Asp 
            100                 105                 110         


Lys Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Asp Asp 
        115                 120                 125             


Ala Thr Ala Gly Leu Thr Asn Met Met Ile Trp His Ser Asn Leu Asn 
    130                 135                 140                 


Asp Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp 
145                 150                 155                 160 


Pro Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser 
                165                 170                 175     


Gly Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu 
            180                 185                 190         


Leu Val Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg 
        195                 200                 205             


Gly Glu Asn Gly Arg Lys Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn 
    210                 215                 220                 


Ile Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Lys Ala Met Met Asp 
225                 230                 235                 240 


Gln Val Arg Glu Ser Arg Asp Pro Gly Asn Ala Glu Phe Glu Asp Leu 
                245                 250                 255     


Thr Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His 
            260                 265                 270         


Lys Ser Cys Leu Pro Ala Cys Val Tyr Gly Pro Ala Val Ala Ser Gly 
        275                 280                 285             


Tyr Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe 
    290                 295                 300                 


Arg Leu Leu Gln Asn Ser Gln Val Tyr Ser Leu Ile Arg Pro Asn Glu 
305                 310                 315                 320 


Asn Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala 
                325                 330                 335     


Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Lys Gly Thr Lys Val 
            340                 345                 350         


Val Pro Arg Gly Lys Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn 
        355                 360                 365             


Glu Asn Met Glu Thr Met Glu Ser Ser Thr Leu Glu Leu Arg Ser Arg 
    370                 375                 380                 


Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg 
385                 390                 395                 400 


Ala Ser Ala Gly Gln Ile Ser Ile Gln Pro Thr Phe Ser Val Gln Arg 
                405                 410                 415     


Asn Leu Pro Phe Asp Arg Thr Thr Val Met Ala Ala Phe Thr Gly Asn 
            420                 425                 430         


Thr Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met 
        435                 440                 445             


Glu Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe 
    450                 455                 460                 


Glu Leu Ser Asp Glu Lys Ala Ala Ser Pro Ile Val Pro Ser Phe Asp 
465                 470                 475                 480 


Met Ser Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr 
                485                 490                 495     


Asp Asn 
        


<210>  51
<211>  1027
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:Matrix protein (M)

<400>  51
agcgaaagca ggtagatatt gaaagatgag tcttctaacc gaggtcgaaa cgtacgttct       60

ctctatcatc ccgtcaggcc ccctcaaagc cgagatcgca cagagacttg aagatgtctt      120

tgcagggaag aacaccgatc ttgaggttct catggaatgg ctaaagacaa gaccaatcct      180

gtcacctctg actaagggga ttttaggatt tgtgttcacg ctcaccgtgc ccagtgagcg      240

aggactgcag cgtagacgct ttgtccaaaa tgcccttaat gggaacgggg atccaaataa      300

catggacaaa gcagttaaac tgtataggaa gctcaagagg gagataacat tccatggggc      360

caaagaaatc tcactcagtt attctgctgg tgcacttgcc agttgtatgg gcctcatata      420

caacaggatg ggggctgtga ccactgaagt ggcatttggc ctggtatgtg caacctgtga      480

acagattgct gactcccagc atcggtctca taggcaaatg gtgacaacaa ccaacccact      540

aatcagacat gagaacagaa tggttttagc cagcactaca gctaaggcta tggagcaaat      600

ggctggatcg agtgagcaag cagcagaggc catggaggtt gctagtcagg ctaggcaaat      660

ggtgcaagcg atgagaacca ttgggactca tcctagctcc agtgctggtc tgaaaaatga      720

tcttcttgaa aatttgcagg cctatcagaa acgaatgggg gtgcagatgc aacggttcaa      780

gtgatcctct cgctattgcc gcaaatatca ttgggatctt gcacttgata ttgtggattc      840

ttgatcgtct ttttttcaaa tgcatttacc gtcgctttaa atacggactg aaaggagggc      900

cttctacgga aggagtgcca aagtctatga gggaagaata tcgaaaggaa cagcagagtg      960

ctgtggatgc tgacgatggt cattttgtca gcatagagct ggagtaaaaa actaccttgt     1020

ttctact                                                               1027


<210>  52
<211>  252
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:Matrix protein (M)

<400>  52

Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro 
1               5                   10                  15      


Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val Phe 
            20                  25                  30          


Ala Gly Lys Asn Thr Asp Leu Glu Ala Leu Met Glu Trp Leu Lys Thr 
        35                  40                  45              


Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 
    50                  55                  60                  


Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val 
65                  70                  75                  80  


Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Lys Ala 
                85                  90                  95      


Val Lys Leu Tyr Arg Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 
            100                 105                 110         


Lys Glu Ile Ser Leu Ser Tyr Ser Ala Gly Ala Leu Ala Ser Cys Met 
        115                 120                 125             


Gly Leu Ile Tyr Asn Arg Met Gly Ala Val Thr Thr Glu Val Ala Phe 
    130                 135                 140                 


Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 
145                 150                 155                 160 


Ser His Arg Gln Met Val Thr Thr Thr Asn Pro Leu Ile Arg His Glu 
                165                 170                 175     


Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met 
            180                 185                 190         


Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala Ser Gln 
        195                 200                 205             


Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His Pro Ser 
    210                 215                 220                 


Ser Ser Ala Gly Leu Lys Asn Asp Leu Leu Glu Asn Leu Gln Ala Tyr 
225                 230                 235                 240 


Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 
                245                 250         


<210>  53
<211>  890
<212>  DNA
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:non-structural protein (NS)

<400>  53
agcaaaagca gggtgacaaa aacataatgg atccaaacac tgtgtcaagc tttcaggtag       60

attgctttct ttggcatgtc cgcaaacgag ttgcagacca agaactaggt gatgccccat      120

tccttgatcg gcttcgccga gatcagaaat ccctaagagg aaggggcagc accctcggtc      180

tggacatcga gacagccaca cgtgctggaa agcagatagt ggagcggatt ctgaaagaag      240

aatccgatga ggcacttaaa atgaccatgg cctctgtacc tgcgtcgcgt tacctaactg      300

acatgactct tgaggaaatg tcaagggact ggtccatgct catacccaag cagaaagtgg      360

caggccctct ttgtatcaga atggaccagg cgatcatgga taagaacatc atactgaaag      420

cgaacttcag tgtgaatttt gaccggctgg agactctaat attgctaagg gctttcaccg      480

aagagggagc aattgttggc gaaatttcac cattgccttc tcttccagga catactgctg      540

aggatgtcaa aaatgcagtt ggagtcctca tcgggggact tgaatggaat gataacacag      600

ttcgagtctc tgaaactcta cagagattcg cttggagaag cagtaatgag aatgggagac      660

ctccactcac tccaaaacag aaacgagaaa tggcgggaac aattaggtca gaagtttgaa      720

gaaataagat ggttgattga agaagtgaga cacaaactga agataacaga gaatagtttt      780

gagcaaataa catttatgca agccttacat ctattgcttg aagtggagca agagataaga      840

actttctcgt ttcagcttat ttagtaataa aaaacaccct tgtttctact                 890


<210>  54
<211>  237
<212>  PRT
<213>  Artificial

<220>
<223>  influenza A/PR/8/34 virus Other feature:non-structural protein (NS)

<400>  54

Met Asp Ser Asn Thr Val Ser Ser Phe Gln Val Asp Cys Phe Leu Trp 
1               5                   10                  15      


His Val Arg Lys Gln Val Val Asp Gln Glu Leu Gly Asp Ala Pro Phe 
            20                  25                  30          


Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Arg Gly Arg Gly Ser 
        35                  40                  45              


Thr Leu Gly Leu Asn Ile Glu Ala Ala Thr Arg Val Gly Lys Gln Ile 
    50                  55                  60                  


Val Glu Arg Ile Leu Lys Glu Glu Ser Asp Glu Ala Leu Arg Met Thr 
65                  70                  75                  80  


Met Ala Ser Ala Pro Ala Ser Arg Tyr Leu Thr Asp Met Thr Ile Glu 
                85                  90                  95      


Glu Leu Ser Arg Asp Trp Phe Met Leu Met Pro Lys Gln Lys Val Glu 
            100                 105                 110         


Gly Pro Leu Cys Ile Arg Ile Asp Gln Ala Ile Met Asp Lys Asn Ile 
        115                 120                 125             


Met Leu Lys Ala Asn Phe Ser Val Ile Phe Asp Arg Leu Glu Thr Leu 
    130                 135                 140                 


Ile Leu Leu Arg Ala Phe Thr Glu Glu Glu Ala Ile Val Gly Glu Ile 
145                 150                 155                 160 


Ser Pro Leu Pro Ser Leu Pro Gly His Thr Ile Glu Asp Val Lys Asn 
                165                 170                 175     


Ala Val Gly Val Leu Ile Gly Gly Leu Glu Trp Asn Asp Asn Thr Val 
            180                 185                 190         


Arg Val Ser Lys Asn Leu Gln Arg Phe Ala Trp Arg Ser Ser Asn Glu 
        195                 200                 205             


Asn Gly Arg His Pro Leu Thr Pro Lys Gln Lys Arg Glu Met Ala Gly 
    210                 215                 220                 


Thr Ile Arg Ser Lys Val Arg Arg Asp Lys Met Ala Asp 
225                 230                 235         






