                         SEQUENCE LISTING

<110>  Amyris, Inc.
       CHUA, Penelope
       LERMAN, Joshua
       SCHERBART, Thomas
       THAKKER, Chandresh
       TSONG, Annie
       JIANG, Hanxiao
 
<120>  METHODS FOR DECOUPLING YIELD AND PRODUCTIVITY OF A NON-CATABOLIC 
       COMPOUND PRODUCED BY A HOST CELL

<130>  4885PCT.1029BS

<140>  PCT/US2020/036417
<141>  2020-06-05

<150>  62/858,152
<151>  2019-06-06

<150>  63/034,883
<151>  2020-06-04

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  486
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Val Gln Arg Leu Leu Pro Gly Ala His Ile Cys Arg Arg Ser Phe 
1               5                   10                  15      


Asn Ser Ser Ala Ile Ile Lys Ser Ser Ala Leu Thr Leu Lys Glu Ala 
            20                  25                  30          


Leu Glu Asn Val Ile Pro Lys Lys Arg Asp Ala Val Lys Lys Leu Lys 
        35                  40                  45              


Ala Cys Tyr Gly Ser Thr Phe Val Gly Pro Ile Thr Ile Ser Ser Val 
    50                  55                  60                  


Leu Gly Gly Met Arg Gly Asn Gln Ser Met Phe Trp Gln Gly Thr Ser 
65                  70                  75                  80  


Leu Asp Pro Glu His Gly Ile Lys Phe Gln Gly Leu Thr Ile Glu Glu 
                85                  90                  95      


Cys Gln Asn Arg Leu Pro Asn Thr Gly Ile Asp Gly Asp Asn Phe Leu 
            100                 105                 110         


Pro Glu Ser Met Leu Trp Leu Leu Met Thr Gly Gly Val Pro Thr Phe 
        115                 120                 125             


Gln Gln Ala Ala Ser Phe Arg Lys Glu Leu Ala Ile Arg Gly Arg Lys 
    130                 135                 140                 


Leu Pro His Tyr Thr Glu Lys Val Leu Ser Ser Leu Pro Lys Asp Met 
145                 150                 155                 160 


His Pro Met Thr Gln Leu Ala Ile Gly Leu Ala Ser Met Asn Lys Gly 
                165                 170                 175     


Ser Leu Phe Ala Thr Asn Tyr Gln Lys Gly Leu Ile Gly Lys Met Glu 
            180                 185                 190         


Phe Trp Lys Asp Thr Leu Glu Asp Ser Leu Asn Leu Ile Ala Ser Leu 
        195                 200                 205             


Pro Leu Leu Thr Gly Arg Ile Tyr Ser Asn Ile Thr Asn Glu Gly His 
    210                 215                 220                 


Pro Leu Gly Gln Tyr Ser Glu Glu Val Asp Trp Cys Thr Asn Ile Cys 
225                 230                 235                 240 


Ser Leu Leu Gly Met Thr Asn Gly Thr Asn Ser Ser Asn Thr Cys Asn 
                245                 250                 255     


Leu Thr Ser Gln Gln Ser Leu Asp Phe Ile Asn Leu Met Arg Leu Tyr 
            260                 265                 270         


Thr Gly Ile His Val Asp His Glu Gly Gly Asn Val Ser Ala His Thr 
        275                 280                 285             


Thr His Leu Val Gly Ser Ala Leu Ser Asp Pro Tyr Leu Ser Tyr Ser 
    290                 295                 300                 


Ser Gly Ile Met Gly Leu Ala Gly Pro Leu His Gly Leu Ala Ala Gln 
305                 310                 315                 320 


Glu Val Val Arg Phe Leu Ile Glu Met Asn Ser Asn Ile Ser Ser Ile 
                325                 330                 335     


Ala Arg Glu Gln Glu Ile Lys Asp Tyr Leu Trp Lys Ile Leu Asn Ser 
            340                 345                 350         


Asn Arg Val Ile Pro Gly Tyr Gly His Ala Val Leu Arg Lys Pro Asp 
        355                 360                 365             


Pro Arg Phe Thr Ala Met Leu Glu Phe Ala Gln Lys Arg Pro Ile Glu 
    370                 375                 380                 


Phe Glu Asn Asp Lys Asn Val Leu Leu Met Gln Lys Leu Ala Glu Ile 
385                 390                 395                 400 


Ala Pro Lys Val Leu Leu Glu His Gly Lys Ser Lys Asn Pro Phe Pro 
                405                 410                 415     


Asn Val Asp Ser Ala Ser Gly Ile Leu Phe Tyr His Tyr Gly Ile Arg 
            420                 425                 430         


Glu Leu Leu Phe Phe Thr Val Ile Phe Gly Cys Ser Arg Ala Met Gly 
        435                 440                 445             


Pro Leu Thr Gln Leu Val Trp Asp Arg Ile Leu Gly Leu Pro Ile Glu 
    450                 455                 460                 


Arg Pro Lys Ser Leu Asn Leu Glu Gly Leu Glu Ala Leu Thr Lys Ala 
465                 470                 475                 480 


Ser Asn Val Asn Lys Leu 
                485     


<210>  2
<211>  479
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Ser Ala Ile Leu Ser Thr Thr Ser Lys Ser Phe Leu Ser Arg Gly 
1               5                   10                  15      


Ser Thr Arg Gln Cys Gln Asn Met Gln Lys Ala Leu Phe Ala Leu Leu 
            20                  25                  30          


Asn Ala Arg His Tyr Ser Ser Ala Ser Glu Gln Thr Leu Lys Glu Arg 
        35                  40                  45              


Phe Ala Glu Ile Ile Pro Ala Lys Ala Glu Glu Ile Lys Lys Phe Lys 
    50                  55                  60                  


Lys Glu His Gly Lys Thr Val Ile Gly Glu Val Leu Leu Glu Gln Ala 
65                  70                  75                  80  


Tyr Gly Gly Met Arg Gly Ile Lys Gly Leu Val Trp Glu Gly Ser Val 
                85                  90                  95      


Leu Asp Pro Glu Glu Gly Ile Arg Phe Arg Gly Arg Thr Ile Pro Glu 
            100                 105                 110         


Ile Gln Arg Glu Leu Pro Lys Ala Glu Gly Ser Thr Glu Pro Leu Pro 
        115                 120                 125             


Glu Ala Leu Phe Trp Leu Leu Leu Thr Gly Glu Ile Pro Thr Asp Ala 
    130                 135                 140                 


Gln Val Lys Ala Leu Ser Ala Asp Leu Ala Ala Arg Ser Glu Ile Pro 
145                 150                 155                 160 


Glu His Val Ile Gln Leu Leu Asp Ser Leu Pro Lys Asp Leu His Pro 
                165                 170                 175     


Met Ala Gln Phe Ser Ile Ala Val Thr Ala Leu Glu Ser Glu Ser Lys 
            180                 185                 190         


Phe Ala Lys Ala Tyr Ala Gln Gly Val Ser Lys Lys Glu Tyr Trp Ser 
        195                 200                 205             


Tyr Thr Phe Glu Asp Ser Leu Asp Leu Leu Gly Lys Leu Pro Val Ile 
    210                 215                 220                 


Ala Ser Lys Ile Tyr Arg Asn Val Phe Lys Asp Gly Lys Ile Thr Ser 
225                 230                 235                 240 


Thr Asp Pro Asn Ala Asp Tyr Gly Lys Asn Leu Ala Gln Leu Leu Gly 
                245                 250                 255     


Tyr Glu Asn Lys Asp Phe Ile Asp Leu Met Arg Leu Tyr Leu Thr Ile 
            260                 265                 270         


His Ser Asp His Glu Gly Gly Asn Val Ser Ala His Thr Thr His Leu 
        275                 280                 285             


Val Gly Ser Ala Leu Ser Ser Pro Tyr Leu Ser Leu Ala Ala Gly Leu 
    290                 295                 300                 


Asn Gly Leu Ala Gly Pro Leu His Gly Arg Ala Asn Gln Glu Val Leu 
305                 310                 315                 320 


Glu Trp Leu Phe Lys Leu Arg Glu Glu Val Lys Gly Asp Tyr Ser Lys 
                325                 330                 335     


Glu Thr Ile Glu Lys Tyr Leu Trp Asp Thr Leu Asn Ala Gly Arg Val 
            340                 345                 350         


Val Pro Gly Tyr Gly His Ala Val Leu Arg Lys Thr Asp Pro Arg Tyr 
        355                 360                 365             


Thr Ala Gln Arg Glu Phe Ala Leu Lys His Phe Pro Asp Tyr Glu Leu 
    370                 375                 380                 


Phe Lys Leu Val Ser Thr Ile Tyr Glu Val Ala Pro Gly Val Leu Thr 
385                 390                 395                 400 


Lys His Gly Lys Thr Lys Asn Pro Trp Pro Asn Val Asp Ser His Ser 
                405                 410                 415     


Gly Val Leu Leu Gln Tyr Tyr Gly Leu Thr Glu Ala Ser Phe Tyr Thr 
            420                 425                 430         


Val Leu Phe Gly Val Ala Arg Ala Ile Gly Val Leu Pro Gln Leu Ile 
        435                 440                 445             


Ile Asp Arg Ala Val Gly Ala Pro Ile Glu Arg Pro Lys Ser Phe Ser 
    450                 455                 460                 


Thr Glu Lys Tyr Lys Glu Leu Val Lys Lys Ile Glu Ser Lys Asn 
465                 470                 475                 


<210>  3
<211>  778
<212>  PRT
<213>  Pseudomonas mevalonii

<400>  3

Met Leu Ser Ala Arg Ser Ala Ile Lys Arg Pro Ile Val Arg Gly Leu 
1               5                   10                  15      


Ala Thr Val Ser Asn Leu Thr Arg Asp Ser Lys Val Asn Gln Asn Leu 
            20                  25                  30          


Leu Glu Asp His Ser Phe Ile Asn Tyr Lys Gln Asn Val Glu Thr Leu 
        35                  40                  45              


Asp Ile Val Arg Lys Arg Leu Asn Arg Pro Phe Thr Tyr Ala Glu Lys 
    50                  55                  60                  


Ile Leu Tyr Gly His Leu Asp Asp Pro His Gly Gln Asp Ile Gln Arg 
65                  70                  75                  80  


Gly Val Ser Tyr Leu Lys Leu Arg Pro Asp Arg Val Ala Cys Gln Asp 
                85                  90                  95      


Ala Thr Ala Gln Met Ala Ile Leu Gln Phe Met Ser Ala Gly Leu Pro 
            100                 105                 110         


Gln Val Ala Lys Pro Val Thr Val His Cys Asp His Leu Ile Gln Ala 
        115                 120                 125             


Gln Val Gly Gly Glu Lys Asp Leu Lys Arg Ala Ile Asp Leu Asn Lys 
    130                 135                 140                 


Glu Val Tyr Asp Phe Leu Ala Ser Ala Thr Ala Lys Tyr Asn Met Gly 
145                 150                 155                 160 


Phe Trp Lys Pro Gly Ser Gly Ile Ile His Gln Ile Val Leu Glu Asn 
                165                 170                 175     


Tyr Ala Phe Pro Gly Ala Leu Ile Ile Gly Thr Asp Ser His Thr Pro 
            180                 185                 190         


Asn Ala Gly Gly Leu Gly Gln Leu Ala Ile Gly Val Gly Gly Ala Asp 
        195                 200                 205             


Ala Val Asp Val Met Ala Gly Arg Pro Trp Glu Leu Lys Ala Pro Lys 
    210                 215                 220                 


Ile Leu Gly Val Lys Leu Thr Gly Lys Met Asn Gly Trp Thr Ser Pro 
225                 230                 235                 240 


Lys Asp Ile Ile Leu Lys Leu Ala Gly Ile Thr Thr Val Lys Gly Gly 
                245                 250                 255     


Thr Gly Lys Ile Val Glu Tyr Phe Gly Asp Gly Val Asp Thr Phe Ser 
            260                 265                 270         


Ala Thr Gly Met Gly Thr Ile Cys Asn Met Gly Ala Glu Ile Gly Ala 
        275                 280                 285             


Thr Thr Ser Val Phe Pro Phe Asn Lys Ser Met Ile Glu Tyr Leu Glu 
    290                 295                 300                 


Ala Thr Gly Arg Gly Lys Ile Ala Asp Phe Ala Lys Leu Tyr His Lys 
305                 310                 315                 320 


Asp Leu Leu Ser Ala Asp Lys Asp Ala Glu Tyr Asp Glu Val Val Glu 
                325                 330                 335     


Ile Asp Leu Asn Thr Leu Glu Pro Tyr Ile Asn Gly Pro Phe Thr Pro 
            340                 345                 350         


Asp Leu Ala Thr Pro Val Ser Lys Met Lys Glu Val Ala Val Ala Asn 
        355                 360                 365             


Asn Trp Pro Leu Asp Val Arg Val Gly Leu Ile Gly Ser Cys Thr Asn 
    370                 375                 380                 


Ser Ser Tyr Glu Asp Met Ser Arg Ser Ala Ser Ile Val Lys Asp Ala 
385                 390                 395                 400 


Ala Ala His Gly Leu Lys Ser Lys Thr Ile Phe Thr Val Thr Pro Gly 
                405                 410                 415     


Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Gln Leu Glu Thr 
            420                 425                 430         


Phe Lys Glu Phe Gly Gly Ile Val Leu Ala Asn Ala Cys Gly Pro Cys 
        435                 440                 445             


Ile Gly Gln Trp Asp Arg Arg Asp Ile Lys Lys Gly Asp Lys Asn Thr 
    450                 455                 460                 


Ile Val Ser Ser Tyr Asn Arg Asn Phe Thr Ser Arg Asn Asp Gly Asn 
465                 470                 475                 480 


Pro Gln Thr His Ala Phe Val Ala Ser Pro Glu Leu Val Thr Ala Phe 
                485                 490                 495     


Ala Ile Ala Gly Asp Leu Arg Phe Asn Pro Leu Thr Asp Lys Leu Lys 
            500                 505                 510         


Asp Lys Asp Gly Asn Glu Phe Met Leu Lys Pro Pro His Gly Asp Gly 
        515                 520                 525             


Leu Pro Gln Arg Gly Tyr Asp Ala Gly Glu Asn Thr Tyr Gln Ala Pro 
    530                 535                 540                 


Pro Ala Asp Arg Ser Thr Val Glu Val Lys Val Ser Pro Thr Ser Asp 
545                 550                 555                 560 


Arg Leu Gln Leu Leu Lys Pro Phe Lys Pro Trp Asp Gly Lys Asp Ala 
                565                 570                 575     


Lys Asp Met Pro Ile Leu Ile Lys Ala Val Gly Lys Thr Thr Thr Asp 
            580                 585                 590         


His Ile Ser Met Ala Gly Pro Trp Leu Lys Tyr Arg Gly His Leu Glu 
        595                 600                 605             


Asn Ile Ser Asn Asn Tyr Met Ile Gly Ala Ile Asn Ala Glu Asn Lys 
    610                 615                 620                 


Lys Ala Asn Cys Val Lys Asn Val Tyr Thr Gly Glu Tyr Lys Gly Val 
625                 630                 635                 640 


Pro Asp Thr Ala Arg Asp Tyr Arg Asp Gln Gly Ile Lys Trp Val Val 
                645                 650                 655     


Ile Gly Asp Glu Asn Phe Gly Glu Gly Ser Ser Arg Glu His Ala Ala 
            660                 665                 670         


Leu Glu Pro Arg Phe Leu Gly Gly Phe Ala Ile Ile Thr Lys Ser Phe 
        675                 680                 685             


Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu Leu Pro Leu 
    690                 695                 700                 


Asn Phe Lys Asn Pro Ala Asp Tyr Asp Lys Ile Asn Pro Asp Asp Arg 
705                 710                 715                 720 


Ile Asp Ile Leu Gly Leu Ala Glu Leu Ala Pro Gly Lys Pro Val Thr 
                725                 730                 735     


Met Arg Val His Pro Lys Asn Gly Lys Pro Trp Asp Ala Val Leu Thr 
            740                 745                 750         


His Thr Phe Asn Asp Glu Gln Ile Glu Trp Phe Lys Tyr Gly Ser Ala 
        755                 760                 765             


Leu Asn Lys Ile Lys Ala Asp Glu Lys Lys 
    770                 775             


<210>  4
<211>  369
<212>  PRT
<213>  Pseudomonas mevalonii

<400>  4

Met Leu Arg Asn Thr Phe Phe Arg Asn Thr Ser Arg Arg Phe Leu Ala 
1               5                   10                  15      


Thr Val Lys Gln Pro Ser Ile Gly Arg Tyr Thr Gly Lys Pro Asn Pro 
            20                  25                  30          


Ser Thr Gly Lys Tyr Thr Val Ser Phe Ile Glu Gly Asp Gly Ile Gly 
        35                  40                  45              


Pro Glu Ile Ser Lys Ser Val Lys Lys Ile Phe Ser Ala Ala Asn Val 
    50                  55                  60                  


Pro Ile Glu Trp Glu Ser Cys Asp Val Ser Pro Ile Phe Val Asn Gly 
65                  70                  75                  80  


Leu Thr Thr Ile Pro Asp Pro Ala Val Gln Ser Ile Thr Lys Asn Leu 
                85                  90                  95      


Val Ala Leu Lys Gly Pro Leu Ala Thr Pro Ile Gly Lys Gly His Arg 
            100                 105                 110         


Ser Leu Asn Leu Thr Leu Arg Lys Thr Phe Gly Leu Phe Ala Asn Val 
        115                 120                 125             


Arg Pro Ala Lys Ser Ile Glu Gly Phe Lys Thr Thr Tyr Glu Asn Val 
    130                 135                 140                 


Asp Leu Val Leu Ile Arg Glu Asn Thr Glu Gly Glu Tyr Ser Gly Ile 
145                 150                 155                 160 


Glu His Ile Val Cys Pro Gly Val Val Gln Ser Ile Lys Leu Ile Thr 
                165                 170                 175     


Arg Asp Ala Ser Glu Arg Val Ile Arg Tyr Ala Phe Glu Tyr Ala Arg 
            180                 185                 190         


Ala Ile Gly Arg Pro Arg Val Ile Val Val His Lys Ser Thr Ile Gln 
        195                 200                 205             


Arg Leu Ala Asp Gly Leu Phe Val Asn Val Ala Lys Glu Leu Ser Lys 
    210                 215                 220                 


Glu Tyr Pro Asp Leu Thr Leu Glu Thr Glu Leu Ile Asp Asn Ser Val 
225                 230                 235                 240 


Leu Lys Val Val Thr Asn Pro Ser Ala Tyr Thr Asp Ala Val Ser Val 
                245                 250                 255     


Cys Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Leu Asn Ser Gly Leu 
            260                 265                 270         


Ser Ala Gly Ser Leu Gly Leu Thr Pro Ser Ala Asn Ile Gly His Lys 
        275                 280                 285             


Ile Ser Ile Phe Glu Ala Val His Gly Ser Ala Pro Asp Ile Ala Gly 
    290                 295                 300                 


Gln Asp Lys Ala Asn Pro Thr Ala Leu Leu Leu Ser Ser Val Met Met 
305                 310                 315                 320 


Leu Asn His Met Gly Leu Thr Asn His Ala Asp Gln Ile Gln Asn Ala 
                325                 330                 335     


Val Leu Ser Thr Ile Ala Ser Gly Pro Glu Asn Arg Thr Gly Asp Leu 
            340                 345                 350         


Ala Gly Thr Ala Thr Thr Ser Ser Phe Thr Glu Ala Val Ile Lys Arg 
        355                 360                 365             


Leu 
    


<210>  5
<211>  360
<212>  PRT
<213>  Silicibacter pomeroyi

<400>  5

Met Leu Asn Arg Thr Ile Ala Lys Arg Thr Leu Ala Thr Ala Ala Gln 
1               5                   10                  15      


Ala Glu Arg Thr Leu Pro Lys Lys Tyr Gly Gly Arg Phe Thr Val Thr 
            20                  25                  30          


Leu Ile Pro Gly Asp Gly Val Gly Lys Glu Ile Thr Asp Ser Val Arg 
        35                  40                  45              


Thr Ile Phe Glu Ala Glu Asn Ile Pro Ile Asp Trp Glu Thr Ile Asn 
    50                  55                  60                  


Ile Lys Gln Thr Asp His Lys Glu Gly Val Tyr Glu Ala Val Glu Ser 
65                  70                  75                  80  


Leu Lys Arg Asn Lys Ile Gly Leu Lys Gly Leu Trp His Thr Pro Ala 
                85                  90                  95      


Asp Gln Thr Gly His Gly Ser Leu Asn Val Ala Leu Arg Lys Gln Leu 
            100                 105                 110         


Asp Ile Tyr Ala Asn Val Ala Leu Phe Lys Ser Leu Lys Gly Val Lys 
        115                 120                 125             


Thr Arg Ile Pro Asp Ile Asp Leu Ile Val Ile Arg Glu Asn Thr Glu 
    130                 135                 140                 


Gly Glu Phe Ser Gly Leu Glu His Glu Ser Val Pro Gly Val Val Glu 
145                 150                 155                 160 


Ser Leu Lys Val Met Thr Arg Pro Lys Thr Glu Arg Ile Ala Arg Phe 
                165                 170                 175     


Ala Phe Asp Phe Ala Lys Lys Tyr Asn Arg Lys Ser Val Thr Ala Val 
            180                 185                 190         


His Lys Ala Asn Ile Met Lys Leu Gly Asp Gly Leu Phe Arg Asn Ile 
        195                 200                 205             


Ile Thr Glu Ile Gly Gln Lys Glu Tyr Pro Asp Ile Asp Val Ser Ser 
    210                 215                 220                 


Ile Ile Val Asp Asn Ala Ser Met Gln Ala Val Ala Lys Pro His Gln 
225                 230                 235                 240 


Phe Asp Val Leu Val Thr Pro Ser Met Tyr Gly Thr Ile Leu Gly Asn 
                245                 250                 255     


Ile Gly Ala Ala Leu Ile Gly Gly Pro Gly Leu Val Ala Gly Ala Asn 
            260                 265                 270         


Phe Gly Arg Asp Tyr Ala Val Phe Glu Pro Gly Ser Arg His Val Gly 
        275                 280                 285             


Leu Asp Ile Lys Gly Gln Asn Val Ala Asn Pro Thr Ala Met Ile Leu 
    290                 295                 300                 


Ser Ser Thr Leu Met Leu Asn His Leu Gly Leu Asn Glu Tyr Ala Thr 
305                 310                 315                 320 


Arg Ile Ser Lys Ala Val His Glu Thr Ile Ala Glu Gly Lys His Thr 
                325                 330                 335     


Thr Arg Asp Ile Gly Gly Ser Ser Ser Thr Thr Asp Phe Thr Asn Glu 
            340                 345                 350         


Ile Ile Asn Lys Leu Ser Thr Met 
        355                 360 


<210>  6
<211>  463
<212>  PRT
<213>  Silicibacter pomeroyi

<400>  6

Met Leu Ser Arg Ala Thr Arg Thr Ala Ala Ala Lys Ser Leu Val Lys 
1               5                   10                  15      


Ser Lys Val Ala Arg Asn Val Met Ala Ala Ser Phe Val Lys Arg His 
            20                  25                  30          


Ala Ser Thr Ser Leu Phe Lys Gln Ala Asn Lys Val Glu Ser Leu Gly 
        35                  40                  45              


Ser Ile Tyr Leu Ser Gly Lys Lys Ile Ser Val Ala Ala Asn Pro Phe 
    50                  55                  60                  


Ser Ile Thr Ser Asn Arg Phe Lys Ser Thr Ser Ile Glu Val Pro Pro 
65                  70                  75                  80  


Met Ala Glu Ser Leu Thr Glu Gly Ser Leu Lys Glu Tyr Thr Lys Asn 
                85                  90                  95      


Val Gly Asp Phe Ile Lys Glu Asp Glu Leu Leu Ala Thr Ile Glu Thr 
            100                 105                 110         


Asp Lys Ile Asp Ile Glu Val Asn Ser Pro Val Ser Gly Thr Val Thr 
        115                 120                 125             


Lys Leu Asn Phe Lys Pro Glu Asp Thr Val Thr Val Gly Glu Glu Leu 
    130                 135                 140                 


Ala Gln Val Glu Pro Gly Glu Ala Pro Ala Glu Gly Ser Gly Glu Ser 
145                 150                 155                 160 


Lys Pro Glu Pro Thr Glu Gln Ala Glu Pro Ser Gln Gly Val Ala Ala 
                165                 170                 175     


Arg Glu Asn Ser Ser Glu Glu Thr Ala Ser Lys Lys Glu Ala Ala Pro 
            180                 185                 190         


Lys Lys Glu Ala Ala Pro Lys Lys Glu Val Thr Glu Pro Lys Lys Ala 
        195                 200                 205             


Asp Gln Pro Lys Lys Thr Val Ser Lys Ala Gln Glu Pro Pro Val Ala 
    210                 215                 220                 


Ser Asn Ser Phe Thr Pro Phe Pro Arg Thr Glu Thr Arg Val Lys Met 
225                 230                 235                 240 


Asn Arg Met Arg Leu Arg Ile Ala Glu Arg Leu Lys Glu Ser Gln Asn 
                245                 250                 255     


Thr Ala Ala Ser Leu Thr Thr Phe Asn Glu Val Asp Met Ser Ala Leu 
            260                 265                 270         


Met Glu Met Arg Lys Leu Tyr Lys Asp Glu Ile Ile Lys Lys Thr Gly 
        275                 280                 285             


Thr Lys Phe Gly Phe Met Gly Leu Phe Ser Lys Ala Cys Thr Leu Ala 
    290                 295                 300                 


Ala Lys Asp Ile Pro Ala Val Asn Gly Ala Ile Glu Gly Asp Gln Ile 
305                 310                 315                 320 


Val Tyr Arg Asp Tyr Thr Asp Ile Ser Val Ala Val Ala Thr Pro Lys 
                325                 330                 335     


Gly Leu Val Thr Pro Val Val Arg Asn Ala Glu Ser Leu Ser Val Leu 
            340                 345                 350         


Asp Ile Glu Asn Glu Ile Val Arg Leu Ser His Lys Ala Arg Asp Gly 
        355                 360                 365             


Lys Leu Thr Leu Glu Asp Met Thr Gly Gly Thr Phe Thr Ile Ser Asn 
    370                 375                 380                 


Gly Gly Val Phe Gly Ser Leu Tyr Gly Thr Pro Ile Ile Asn Ser Pro 
385                 390                 395                 400 


Gln Thr Ala Val Leu Gly Leu His Gly Val Lys Glu Arg Pro Val Thr 
                405                 410                 415     


Val Asn Gly Gln Ile Val Ser Arg Pro Met Met Tyr Leu Ala Leu Thr 
            420                 425                 430         


Tyr Asp His Arg Leu Leu Asp Gly Arg Glu Ala Val Thr Phe Leu Lys 
        435                 440                 445             


Thr Val Lys Glu Leu Ile Glu Asp Pro Arg Lys Met Leu Leu Trp 
    450                 455                 460             


<210>  7
<211>  1014
<212>  PRT
<213>  Delftia acidovorans

<400>  7

Met Leu Arg Phe Val Ser Ser Gln Thr Cys Arg Tyr Ser Ser Arg Gly 
1               5                   10                  15      


Leu Leu Lys Thr Ser Leu Leu Lys Asn Ala Ser Thr Val Lys Ile Val 
            20                  25                  30          


Gly Arg Gly Leu Ala Thr Thr Gly Thr Asp Asn Phe Leu Ser Thr Ser 
        35                  40                  45              


Asn Ala Thr Tyr Ile Asp Glu Met Tyr Gln Ala Trp Gln Lys Asp Pro 
    50                  55                  60                  


Ser Ser Val His Val Ser Trp Asp Ala Tyr Phe Lys Asn Met Ser Asn 
65                  70                  75                  80  


Pro Lys Ile Pro Ala Thr Lys Ala Phe Gln Ala Pro Pro Ser Ile Ser 
                85                  90                  95      


Asn Phe Pro Gln Gly Thr Glu Ala Ala Pro Leu Gly Thr Ala Met Thr 
            100                 105                 110         


Gly Ser Val Asp Glu Asn Val Ser Ile His Leu Lys Val Gln Leu Leu 
        115                 120                 125             


Cys Arg Ala Tyr Gln Val Arg Gly His Leu Lys Ala His Ile Asp Pro 
    130                 135                 140                 


Leu Gly Ile Ser Phe Gly Ser Asn Lys Asn Asn Pro Val Pro Pro Glu 
145                 150                 155                 160 


Leu Thr Leu Asp Tyr Tyr Gly Phe Ser Lys His Asp Leu Asp Lys Glu 
                165                 170                 175     


Ile Asn Leu Gly Pro Gly Ile Leu Pro Arg Phe Ala Arg Asp Gly Lys 
            180                 185                 190         


Ser Lys Met Ser Leu Lys Glu Ile Val Asp His Leu Glu Lys Leu Tyr 
        195                 200                 205             


Cys Ser Ser Tyr Gly Val Gln Tyr Thr His Ile Pro Ser Lys Gln Lys 
    210                 215                 220                 


Cys Asp Trp Leu Arg Glu Arg Ile Glu Ile Pro Glu Pro Tyr Gln Tyr 
225                 230                 235                 240 


Thr Val Asp Gln Lys Arg Gln Ile Leu Asp Arg Leu Thr Trp Ala Thr 
                245                 250                 255     


Ser Phe Glu Ser Phe Leu Ser Thr Lys Phe Pro Asn Asp Lys Arg Phe 
            260                 265                 270         


Gly Leu Glu Gly Leu Glu Ser Val Val Pro Gly Ile Lys Thr Leu Val 
        275                 280                 285             


Asp Arg Ser Val Glu Leu Gly Val Glu Asp Ile Val Leu Gly Met Ala 
    290                 295                 300                 


His Arg Gly Arg Leu Asn Val Leu Ser Asn Val Val Arg Lys Pro Asn 
305                 310                 315                 320 


Glu Ser Ile Phe Ser Glu Phe Lys Gly Ser Ser Ala Arg Asp Asp Ile 
                325                 330                 335     


Glu Gly Ser Gly Asp Val Lys Tyr His Leu Gly Met Asn Tyr Gln Arg 
            340                 345                 350         


Pro Thr Thr Ser Gly Lys Tyr Val Asn Leu Ser Leu Val Ala Asn Pro 
        355                 360                 365             


Ser His Leu Glu Ser Gln Asp Pro Val Val Leu Gly Arg Thr Arg Ala 
    370                 375                 380                 


Leu Leu His Ala Lys Asn Asp Leu Lys Glu Lys Thr Lys Ala Leu Gly 
385                 390                 395                 400 


Val Leu Leu His Gly Asp Ala Ala Phe Ala Gly Gln Gly Val Val Tyr 
                405                 410                 415     


Glu Thr Met Gly Phe Leu Thr Leu Pro Glu Tyr Ser Thr Gly Gly Thr 
            420                 425                 430         


Ile His Val Ile Thr Asn Asn Gln Ile Gly Phe Thr Thr Asp Pro Arg 
        435                 440                 445             


Phe Ala Arg Ser Thr Pro Tyr Pro Ser Asp Leu Ala Lys Ala Ile Asp 
    450                 455                 460                 


Ala Pro Ile Phe His Val Asn Ala Asn Asp Val Glu Ala Val Thr Phe 
465                 470                 475                 480 


Ile Phe Asn Leu Ala Ala Glu Trp Arg His Lys Phe His Thr Asp Ala 
                485                 490                 495     


Ile Ile Asp Val Val Gly Trp Arg Lys His Gly His Asn Glu Thr Asp 
            500                 505                 510         


Gln Pro Ser Phe Thr Gln Pro Leu Met Tyr Lys Lys Ile Ala Lys Gln 
        515                 520                 525             


Lys Ser Val Ile Asp Val Tyr Thr Glu Lys Leu Ile Ser Glu Gly Thr 
    530                 535                 540                 


Phe Ser Lys Lys Asp Ile Asp Glu His Lys Lys Trp Val Trp Asn Leu 
545                 550                 555                 560 


Phe Glu Asp Ala Phe Glu Lys Ala Lys Asp Tyr Val Pro Ser Gln Arg 
                565                 570                 575     


Glu Trp Leu Thr Ala Ala Trp Glu Gly Phe Lys Ser Pro Lys Glu Leu 
            580                 585                 590         


Ala Thr Glu Ile Leu Pro His Glu Pro Thr Asn Val Pro Glu Ser Thr 
        595                 600                 605             


Leu Lys Glu Leu Gly Lys Val Leu Ser Ser Trp Pro Glu Gly Phe Glu 
    610                 615                 620                 


Val His Lys Asn Leu Lys Arg Ile Leu Lys Asn Arg Gly Lys Ser Ile 
625                 630                 635                 640 


Glu Thr Gly Glu Gly Ile Asp Trp Ala Thr Gly Glu Ala Leu Ala Phe 
                645                 650                 655     


Gly Thr Leu Val Leu Asp Gly Gln Asn Val Arg Val Ser Gly Glu Asp 
            660                 665                 670         


Val Glu Arg Gly Thr Phe Ser Gln Arg His Ala Val Leu His Asp Gln 
        675                 680                 685             


Gln Ser Glu Ala Ile Tyr Thr Pro Leu Ser Thr Leu Asn Asn Glu Lys 
    690                 695                 700                 


Ala Asp Phe Thr Ile Ala Asn Ser Ser Leu Ser Glu Tyr Gly Val Met 
705                 710                 715                 720 


Gly Phe Glu Tyr Gly Tyr Ser Leu Thr Ser Pro Asp Tyr Leu Val Met 
                725                 730                 735     


Trp Glu Ala Gln Phe Gly Asp Phe Ala Asn Thr Ala Gln Val Ile Ile 
            740                 745                 750         


Asp Gln Phe Ile Ala Gly Gly Glu Gln Lys Trp Lys Gln Arg Ser Gly 
        755                 760                 765             


Leu Val Leu Ser Leu Pro His Gly Tyr Asp Gly Gln Gly Pro Glu His 
    770                 775                 780                 


Ser Ser Gly Arg Leu Glu Arg Phe Leu Gln Leu Ala Asn Glu Asp Pro 
785                 790                 795                 800 


Arg Tyr Phe Pro Ser Glu Glu Lys Leu Gln Arg Gln His Gln Asp Cys 
                805                 810                 815     


Asn Phe Gln Val Val Tyr Pro Thr Thr Pro Ala Asn Leu Phe His Ile 
            820                 825                 830         


Leu Arg Arg Gln Gln His Arg Gln Phe Arg Lys Pro Leu Ala Leu Phe 
        835                 840                 845             


Phe Ser Lys Gln Leu Leu Arg His Pro Leu Ala Arg Ser Ser Leu Ser 
    850                 855                 860                 


Glu Phe Thr Glu Gly Gly Phe Gln Trp Ile Ile Glu Asp Ile Glu His 
865                 870                 875                 880 


Gly Lys Ser Ile Gly Thr Lys Glu Glu Thr Lys Arg Leu Val Leu Leu 
                885                 890                 895     


Ser Gly Gln Val Tyr Thr Ala Leu His Lys Arg Arg Glu Ser Leu Gly 
            900                 905                 910         


Asp Lys Thr Thr Ala Phe Leu Lys Ile Glu Gln Leu His Pro Phe Pro 
        915                 920                 925             


Phe Ala Gln Leu Arg Asp Ser Leu Asn Ser Tyr Pro Asn Leu Glu Glu 
    930                 935                 940                 


Ile Val Trp Cys Gln Glu Glu Pro Leu Asn Met Gly Ser Trp Ala Tyr 
945                 950                 955                 960 


Thr Glu Pro Arg Leu His Thr Thr Leu Lys Glu Thr Asp Lys Tyr Lys 
                965                 970                 975     


Asp Phe Lys Val Arg Tyr Cys Gly Arg Asn Pro Ser Gly Ala Val Ala 
            980                 985                 990         


Ala Gly Ser Lys Ser Leu His Leu  Ala Glu Glu Asp Ala  Phe Leu Lys 
        995                 1000                 1005             


Asp Val  Phe Gln Gln Ser 
    1010                 


<210>  8
<211>  499
<212>  PRT
<213>  Delftia acidovorans

<400>  8

Met Leu Arg Ile Arg Ser Leu Leu Asn Asn Lys Arg Ala Phe Ser Ser 
1               5                   10                  15      


Thr Val Arg Thr Leu Thr Ile Asn Lys Ser His Asp Val Val Ile Ile 
            20                  25                  30          


Gly Gly Gly Pro Ala Gly Tyr Val Ala Ala Ile Lys Ala Ala Gln Leu 
        35                  40                  45              


Gly Phe Asn Thr Ala Cys Val Glu Lys Arg Gly Lys Leu Gly Gly Thr 
    50                  55                  60                  


Cys Leu Asn Val Gly Cys Ile Pro Ser Lys Ala Leu Leu Asn Asn Ser 
65                  70                  75                  80  


His Leu Phe His Gln Met His Thr Glu Ala Gln Lys Arg Gly Ile Asp 
                85                  90                  95      


Val Asn Gly Asp Ile Lys Ile Asn Val Ala Asn Phe Gln Lys Ala Lys 
            100                 105                 110         


Asp Asp Ala Val Lys Gln Leu Thr Gly Gly Ile Glu Leu Leu Phe Lys 
        115                 120                 125             


Lys Asn Lys Val Thr Tyr Tyr Lys Gly Asn Gly Ser Phe Glu Asp Glu 
    130                 135                 140                 


Thr Lys Ile Arg Val Thr Pro Val Asp Gly Leu Glu Gly Thr Val Lys 
145                 150                 155                 160 


Glu Asp His Ile Leu Asp Val Lys Asn Ile Ile Val Ala Thr Gly Ser 
                165                 170                 175     


Glu Val Thr Pro Phe Pro Gly Ile Glu Ile Asp Glu Glu Lys Ile Val 
            180                 185                 190         


Ser Ser Thr Gly Ala Leu Ser Leu Lys Glu Ile Pro Lys Arg Leu Thr 
        195                 200                 205             


Ile Ile Gly Gly Gly Ile Ile Gly Leu Glu Met Gly Ser Val Tyr Ser 
    210                 215                 220                 


Arg Leu Gly Ser Lys Val Thr Val Val Glu Phe Gln Pro Gln Ile Gly 
225                 230                 235                 240 


Ala Ser Met Asp Gly Glu Val Ala Lys Ala Thr Gln Lys Phe Leu Lys 
                245                 250                 255     


Lys Gln Gly Leu Asp Phe Lys Leu Ser Thr Lys Val Ile Ser Ala Lys 
            260                 265                 270         


Arg Asn Asp Asp Lys Asn Val Val Glu Ile Val Val Glu Asp Thr Lys 
        275                 280                 285             


Thr Asn Lys Gln Glu Asn Leu Glu Ala Glu Val Leu Leu Val Ala Val 
    290                 295                 300                 


Gly Arg Arg Pro Tyr Ile Ala Gly Leu Gly Ala Glu Lys Ile Gly Leu 
305                 310                 315                 320 


Glu Val Asp Lys Arg Gly Arg Leu Val Ile Asp Asp Gln Phe Asn Ser 
                325                 330                 335     


Lys Phe Pro His Ile Lys Val Val Gly Asp Val Thr Phe Gly Pro Met 
            340                 345                 350         


Leu Ala His Lys Ala Glu Glu Glu Gly Ile Ala Ala Val Glu Met Leu 
        355                 360                 365             


Lys Thr Gly His Gly His Val Asn Tyr Asn Asn Ile Pro Ser Val Met 
    370                 375                 380                 


Tyr Ser His Pro Glu Val Ala Trp Val Gly Lys Thr Glu Glu Gln Leu 
385                 390                 395                 400 


Lys Glu Ala Gly Ile Asp Tyr Lys Ile Gly Lys Phe Pro Phe Ala Ala 
                405                 410                 415     


Asn Ser Arg Ala Lys Thr Asn Gln Asp Thr Glu Gly Phe Val Lys Ile 
            420                 425                 430         


Leu Ile Asp Ser Lys Thr Glu Arg Ile Leu Gly Ala His Ile Ile Gly 
        435                 440                 445             


Pro Asn Ala Gly Glu Met Ile Ala Glu Ala Gly Leu Ala Leu Glu Tyr 
    450                 455                 460                 


Gly Ala Ser Ala Glu Asp Val Ala Arg Val Cys His Ala His Pro Thr 
465                 470                 475                 480 


Leu Ser Glu Ala Phe Lys Glu Ala Asn Met Ala Ala Tyr Asp Lys Ala 
                485                 490                 495     


Ile His Cys 
            


<210>  9
<211>  427
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Tyr Ser Arg Lys Ser Leu Ser Leu Ile Ser Lys Cys Gly Gln Leu 
1               5                   10                  15      


Ser Arg Leu Asn Ala Gln Ala Ala Leu Gln Ala Arg Arg His Leu Ser 
            20                  25                  30          


Ile His Glu Tyr Arg Ser Ala Gln Leu Leu Arg Glu Tyr Gly Ile Gly 
        35                  40                  45              


Thr Pro Glu Gly Phe Pro Ala Phe Thr Pro Glu Glu Ala Phe Glu Ala 
    50                  55                  60                  


Ala Lys Lys Leu Asn Thr Asn Lys Leu Val Ile Lys Ala Gln Ala Leu 
65                  70                  75                  80  


Thr Gly Gly Arg Gly Lys Gly His Phe Asp Thr Gly Tyr Lys Ser Gly 
                85                  90                  95      


Val His Met Ile Glu Ser Pro Gln Gln Ala Glu Asp Val Ala Lys Glu 
            100                 105                 110         


Met Leu Asn His Asn Leu Ile Thr Lys Gln Thr Gly Ile Ala Gly Lys 
        115                 120                 125             


Pro Val Ser Ala Val Tyr Ile Val Lys Arg Val Asp Thr Lys His Glu 
    130                 135                 140                 


Ala Tyr Leu Ser Ile Leu Met Asp Arg Gln Thr Lys Lys Pro Met Ile 
145                 150                 155                 160 


Ile Ala Ser Ser Gln Gly Gly Met Asn Ile Glu Glu Val Ala Glu Arg 
                165                 170                 175     


Thr Pro Asp Ala Ile Lys Lys Phe Ser Ile Glu Thr Ser Lys Gly Leu 
            180                 185                 190         


Ser Pro Gln Met Ala Lys Asp Val Ala Lys Ser Leu Gly Phe Ser Pro 
        195                 200                 205             


Asp Ala Gln Asp Glu Ala Ala Lys Ala Val Ser Asn Leu Tyr Lys Ile 
    210                 215                 220                 


Phe Met Glu Arg Asp Ala Thr Gln Val Glu Ile Asn Pro Leu Ser Glu 
225                 230                 235                 240 


Ile Glu His Asp Pro Thr His Lys Ile Met Cys Thr Asp Ala Lys Phe 
                245                 250                 255     


Gly Phe Asp Asp Asn Ala Ser Phe Arg Gln Glu Lys Ile Tyr Ser Trp 
            260                 265                 270         


Arg Asp Leu Ser Gln Glu Asp Pro Asp Glu Val Lys Ala Lys Lys Tyr 
        275                 280                 285             


Asp Leu Asn Phe Val Lys Leu Lys Gly Asn Ile Gly Cys Leu Val Asn 
    290                 295                 300                 


Gly Ala Gly Leu Ala Met Ala Thr Met Asp Val Ile Lys Leu Asn Gly 
305                 310                 315                 320 


Gly Asp Pro Ala Asn Phe Leu Asp Cys Gly Gly Gly Ala Thr Pro Glu 
                325                 330                 335     


Thr Ile Lys Gln Gly Phe Glu Leu Ile Leu Ser Asn Lys Asn Val Asp 
            340                 345                 350         


Ala Ile Phe Val Asn Ile Phe Gly Gly Ile Val Arg Cys Asp Tyr Val 
        355                 360                 365             


Ala Leu Gly Leu Val Glu Ala Ala Arg Glu Leu Glu Val Arg Val Pro 
    370                 375                 380                 


Ile Val Ala Arg Leu Gln Gly Thr Lys Val Glu Glu Gly Arg Asp Ile 
385                 390                 395                 400 


Ile Asn Lys Ser Gly Val Lys Ile Tyr Ser Phe Asp Glu Leu Asp Pro 
                405                 410                 415     


Ala Ala Lys Lys Val Val Glu Leu Thr Gln Asn 
            420                 425         


<210>  10
<211>  329
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  10

Met Leu Arg Ser Thr Val Ser Lys Ala Ser Leu Lys Ile Cys Arg His 
1               5                   10                  15      


Phe His Arg Glu Ser Ile Pro Tyr Asp Lys Thr Ile Lys Asn Leu Leu 
            20                  25                  30          


Leu Pro Lys Asp Thr Lys Val Ile Phe Gln Gly Phe Thr Gly Lys Gln 
        35                  40                  45              


Gly Thr Phe His Ala Ser Ile Ser Gln Glu Tyr Gly Thr Asn Val Val 
    50                  55                  60                  


Gly Gly Thr Asn Pro Lys Lys Ala Gly Gln Thr His Leu Gly Gln Pro 
65                  70                  75                  80  


Val Phe Ala Ser Val Lys Asp Ala Ile Lys Glu Thr Gly Ala Thr Ala 
                85                  90                  95      


Ser Ala Ile Phe Val Pro Pro Pro Ile Ala Ala Ala Ala Ile Lys Glu 
            100                 105                 110         


Ser Ile Glu Ala Glu Ile Pro Leu Ala Val Cys Ile Thr Glu Gly Ile 
        115                 120                 125             


Pro Gln His Asp Met Leu Tyr Ile Ala Glu Met Leu Gln Thr Gln Asp 
    130                 135                 140                 


Lys Thr Arg Leu Val Gly Pro Asn Cys Pro Gly Ile Ile Asn Pro Ala 
145                 150                 155                 160 


Thr Lys Val Arg Ile Gly Ile Gln Pro Pro Lys Ile Phe Gln Ala Gly 
                165                 170                 175     


Lys Ile Gly Ile Ile Ser Arg Ser Gly Thr Leu Thr Tyr Glu Ala Val 
            180                 185                 190         


Gln Gln Thr Thr Lys Thr Asp Leu Gly Gln Ser Leu Val Ile Gly Met 
        195                 200                 205             


Gly Gly Asp Ala Phe Pro Gly Thr Asp Phe Ile Asp Ala Leu Lys Leu 
    210                 215                 220                 


Phe Leu Glu Asp Glu Thr Thr Glu Gly Ile Ile Met Leu Gly Glu Ile 
225                 230                 235                 240 


Gly Gly Lys Ala Glu Ile Glu Ala Ala Gln Phe Leu Lys Glu Tyr Asn 
                245                 250                 255     


Phe Ser Arg Ser Lys Pro Met Pro Val Ala Ser Phe Ile Ala Gly Thr 
            260                 265                 270         


Val Ala Gly Gln Met Lys Gly Val Arg Met Gly His Ser Gly Ala Ile 
        275                 280                 285             


Val Glu Gly Ser Gly Thr Asp Ala Glu Ser Lys Lys Gln Ala Leu Arg 
    290                 295                 300                 


Asp Val Gly Val Ala Val Val Glu Ser Pro Gly Tyr Leu Gly Gln Ala 
305                 310                 315                 320 


Leu Leu Asp Gln Phe Ala Lys Phe Lys 
                325                 


<210>  11
<211>  640
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  11

Met Leu Ser Leu Lys Lys Ser Ala Leu Ser Lys Leu Thr Leu Leu Arg 
1               5                   10                  15      


Asn Thr Arg Thr Phe Thr Ser Ser Ala Leu Val Arg Gln Thr Gln Gly 
            20                  25                  30          


Ser Val Asn Gly Ser Ala Ser Arg Ser Ala Asp Gly Lys Tyr His Ile 
        35                  40                  45              


Ile Asp His Glu Tyr Asp Cys Val Val Ile Gly Ala Gly Gly Ala Gly 
    50                  55                  60                  


Leu Arg Ala Ala Phe Gly Leu Ala Glu Ala Gly Tyr Lys Thr Ala Cys 
65                  70                  75                  80  


Ile Ser Lys Leu Phe Pro Thr Arg Ser His Thr Val Ala Ala Gln Gly 
                85                  90                  95      


Gly Ile Asn Ala Ala Leu Gly Asn Met His Lys Asp Asn Trp Lys Trp 
            100                 105                 110         


His Met Tyr Asp Thr Val Lys Gly Ser Asp Trp Leu Gly Asp Gln Asp 
        115                 120                 125             


Ser Ile His Tyr Met Thr Arg Glu Ala Pro Lys Ser Ile Ile Glu Leu 
    130                 135                 140                 


Glu His Tyr Gly Val Pro Phe Ser Arg Thr Glu Asn Gly Lys Ile Tyr 
145                 150                 155                 160 


Gln Arg Ala Phe Gly Gly Gln Thr Lys Glu Tyr Gly Lys Gly Ala Gln 
                165                 170                 175     


Ala Tyr Arg Thr Cys Ala Val Ala Asp Arg Thr Gly His Ala Leu Leu 
            180                 185                 190         


His Thr Leu Tyr Gly Gln Ala Leu Arg His Asp Thr His Phe Phe Ile 
        195                 200                 205             


Glu Tyr Phe Ala Leu Asp Leu Leu Thr His Asn Gly Glu Val Val Gly 
    210                 215                 220                 


Val Ile Ala Tyr Asn Gln Glu Asp Gly Thr Ile His Arg Phe Arg Ala 
225                 230                 235                 240 


His Lys Thr Ile Ile Ala Thr Gly Gly Tyr Gly Arg Ala Tyr Phe Ser 
                245                 250                 255     


Cys Thr Ser Ala His Thr Cys Thr Gly Asp Gly Asn Ala Met Val Ser 
            260                 265                 270         


Arg Ala Gly Phe Pro Leu Gln Asp Leu Glu Phe Val Gln Phe His Pro 
        275                 280                 285             


Ser Gly Ile Tyr Gly Ser Gly Cys Leu Ile Thr Glu Gly Ala Arg Gly 
    290                 295                 300                 


Glu Gly Gly Phe Leu Val Asn Ser Glu Gly Glu Arg Phe Met Glu Arg 
305                 310                 315                 320 


Tyr Ala Pro Thr Ala Lys Asp Leu Ala Cys Arg Asp Val Val Ser Arg 
                325                 330                 335     


Ala Ile Thr Met Glu Ile Arg Glu Gly Arg Gly Val Gly Lys Lys Lys 
            340                 345                 350         


Asp His Met Tyr Leu Gln Leu Ser His Leu Pro Pro Glu Val Leu Lys 
        355                 360                 365             


Glu Arg Leu Pro Gly Ile Ser Glu Thr Ala Ala Ile Phe Ala Gly Val 
    370                 375                 380                 


Asp Val Thr Lys Glu Pro Ile Pro Ile Ile Pro Thr Val His Tyr Asn 
385                 390                 395                 400 


Met Gly Gly Ile Pro Thr Lys Trp Asn Gly Glu Ala Leu Thr Ile Asp 
                405                 410                 415     


Glu Glu Thr Gly Glu Asp Lys Val Ile Pro Gly Leu Met Ala Cys Gly 
            420                 425                 430         


Glu Ala Ala Cys Val Ser Val His Gly Ala Asn Arg Leu Gly Ala Asn 
        435                 440                 445             


Ser Leu Leu Asp Leu Val Val Phe Gly Arg Ala Val Ala His Thr Val 
    450                 455                 460                 


Ala Asp Thr Leu Gln Pro Gly Leu Pro His Lys Pro Leu Pro Ser Asp 
465                 470                 475                 480 


Leu Gly Lys Glu Ser Ile Ala Asn Leu Asp Lys Leu Arg Asn Ala Asn 
                485                 490                 495     


Gly Ser Arg Ser Thr Ala Glu Ile Arg Met Asn Met Lys Gln Thr Met 
            500                 505                 510         


Gln Lys Asp Val Ser Val Phe Arg Thr Gln Ser Ser Leu Asp Glu Gly 
        515                 520                 525             


Val Arg Asn Ile Thr Ala Val Glu Lys Thr Phe Asp Asp Val Lys Thr 
    530                 535                 540                 


Thr Asp Arg Ser Met Ile Trp Asn Ser Asp Leu Val Glu Thr Leu Glu 
545                 550                 555                 560 


Leu Gln Asn Leu Leu Thr Cys Ala Ser Gln Thr Ala Val Ser Ala Ala 
                565                 570                 575     


Asn Arg Lys Glu Ser Arg Gly Ala His Ala Arg Glu Asp Tyr Pro Asn 
            580                 585                 590         


Arg Asp Asp Glu His Trp Met Lys His Thr Leu Ser Trp Gln Lys Asp 
        595                 600                 605             


Val Ala Ala Pro Val Thr Leu Lys Tyr Arg Arg Val Ile Asp His Thr 
    610                 615                 620                 


Leu Asp Glu Lys Glu Cys Pro Ser Val Pro Pro Thr Val Arg Ala Tyr 
625                 630                 635                 640 


<210>  12
<211>  266
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  12

Met Leu Asn Val Leu Leu Arg Arg Lys Ala Phe Cys Leu Val Thr Lys 
1               5                   10                  15      


Lys Gly Met Ala Thr Ala Thr Thr Ala Ala Ala Thr His Thr Pro Arg 
            20                  25                  30          


Leu Lys Thr Phe Lys Val Tyr Arg Trp Asn Pro Asp Glu Pro Ser Ala 
        35                  40                  45              


Lys Pro His Leu Gln Ser Tyr Gln Val Asp Leu Asn Asp Cys Gly Pro 
    50                  55                  60                  


Met Val Leu Asp Ala Leu Leu Lys Ile Lys Asp Glu Gln Asp Ser Thr 
65                  70                  75                  80  


Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser Cys Ala 
                85                  90                  95      


Met Asn Ile Gly Gly Arg Asn Thr Leu Ala Cys Ile Cys Lys Ile Asp 
            100                 105                 110         


Gln Asn Glu Ser Lys Gln Leu Lys Ile Tyr Pro Leu Pro His Met Phe 
        115                 120                 125             


Ile Val Lys Asp Leu Val Pro Asp Leu Thr Asn Phe Tyr Gln Gln Tyr 
    130                 135                 140                 


Lys Ser Ile Gln Pro Tyr Leu Gln Arg Ser Ser Phe Pro Lys Asp Gly 
145                 150                 155                 160 


Thr Glu Val Leu Gln Ser Ile Glu Asp Arg Lys Lys Leu Asp Gly Leu 
                165                 170                 175     


Tyr Glu Cys Ile Leu Cys Ala Cys Cys Ser Thr Ser Cys Pro Ser Tyr 
            180                 185                 190         


Trp Trp Asn Gln Glu Gln Tyr Leu Gly Pro Ala Val Leu Met Gln Ala 
        195                 200                 205             


Tyr Arg Trp Leu Ile Asp Ser Arg Asp Gln Ala Thr Lys Thr Arg Lys 
    210                 215                 220                 


Ala Met Leu Asn Asn Ser Met Ser Leu Tyr Arg Cys His Thr Ile Met 
225                 230                 235                 240 


Asn Cys Thr Arg Thr Cys Pro Lys Gly Leu Asn Pro Gly Leu Ala Ile 
                245                 250                 255     


Ala Glu Ile Lys Lys Ser Leu Ala Phe Ala 
            260                 265     


<210>  13
<211>  198
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Ser Ala Met Met Val Lys Leu Gly Leu Asn Lys Ser Ala Leu Leu 
1               5                   10                  15      


Leu Lys Pro Ser Ala Phe Ser Arg Ala Ala Ala Leu Ser Ser Ser Arg 
            20                  25                  30          


Arg Leu Leu Phe Asn Thr Ala Arg Thr Asn Phe Leu Ser Thr Ser Pro 
        35                  40                  45              


Leu Lys Asn Val Ala Ser Glu Met Asn Thr Lys Ala Ala Ile Ala Glu 
    50                  55                  60                  


Glu Gln Ile Leu Asn Lys Gln Arg Ala Lys Arg Pro Ile Ser Pro His 
65                  70                  75                  80  


Leu Thr Ile Tyr Gln Pro Gln Leu Thr Trp Tyr Leu Ser Ser Leu His 
                85                  90                  95      


Arg Ile Ser Leu Val Leu Met Gly Leu Gly Phe Tyr Leu Phe Thr Ile 
            100                 105                 110         


Leu Phe Gly Val Ser Gly Leu Leu Gly Leu Gly Leu Thr Thr Glu Lys 
        115                 120                 125             


Val Ser Asn Trp Tyr His Gln Lys Phe Ser Lys Ile Thr Glu Trp Ser 
    130                 135                 140                 


Ile Lys Gly Ser Phe Ala Tyr Leu Phe Ala Ile His Tyr Gly Gly Ala 
145                 150                 155                 160 


Ile Arg His Leu Ile Trp Asp Thr Ala Lys Glu Leu Thr Leu Lys Gly 
                165                 170                 175     


Val Tyr Arg Thr Gly Tyr Ala Leu Ile Gly Phe Thr Ala Val Leu Gly 
            180                 185                 190         


Thr Tyr Leu Leu Thr Leu 
        195             


<210>  14
<211>  488
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Leu Arg Phe Thr Asn Cys Ser Cys Lys Thr Phe Val Lys Ser Ser 
1               5                   10                  15      


Tyr Lys Leu Asn Ile Arg Arg Met Asn Ser Ser Phe Arg Thr Glu Thr 
            20                  25                  30          


Asp Ala Phe Gly Glu Ile His Val Pro Ala Asp Lys Tyr Trp Gly Ala 
        35                  40                  45              


Gln Thr Gln Arg Ser Phe Gln Asn Phe Lys Ile Gly Gly Ala Arg Glu 
    50                  55                  60                  


Arg Met Pro Leu Pro Leu Val His Ala Phe Gly Val Leu Lys Lys Ser 
65                  70                  75                  80  


Ala Ala Ile Val Asn Glu Ser Leu Gly Gly Leu Asp Pro Lys Ile Ser 
                85                  90                  95      


Lys Ala Ile Gln Gln Ala Ala Asp Glu Val Ala Ser Gly Lys Leu Asp 
            100                 105                 110         


Asp His Phe Pro Leu Val Val Phe Gln Thr Gly Ser Gly Thr Gln Ser 
        115                 120                 125             


Asn Met Asn Ala Asn Glu Val Ile Ser Asn Arg Ala Ile Glu Ile Leu 
    130                 135                 140                 


Gly Gly Lys Ile Gly Ser Lys Gln Val His Pro Asn Asn His Cys Asn 
145                 150                 155                 160 


Gln Ser Gln Ser Ser Asn Asp Thr Phe Pro Thr Val Met His Ile Ala 
                165                 170                 175     


Ala Ser Leu Gln Ile Gln Asn Glu Leu Ile Pro Glu Leu Thr Asn Leu 
            180                 185                 190         


Lys Asn Ala Leu Glu Ala Lys Ser Lys Glu Phe Asp His Ile Val Lys 
        195                 200                 205             


Ile Gly Arg Thr His Leu Gln Asp Ala Thr Pro Leu Thr Leu Gly Gln 
    210                 215                 220                 


Glu Phe Ser Gly Tyr Val Gln Gln Val Glu Asn Gly Ile Gln Arg Val 
225                 230                 235                 240 


Ala His Ser Leu Lys Thr Leu Ser Phe Leu Ala Gln Gly Gly Thr Ala 
                245                 250                 255     


Val Gly Thr Gly Leu Asn Thr Lys Pro Gly Phe Asp Val Lys Ile Ala 
            260                 265                 270         


Glu Gln Ile Ser Lys Glu Thr Gly Leu Lys Phe Gln Thr Ala Pro Asn 
        275                 280                 285             


Lys Phe Glu Ala Leu Ala Ala His Asp Ala Ile Val Glu Cys Ser Gly 
    290                 295                 300                 


Ala Leu Asn Thr Leu Ala Cys Ser Leu Phe Lys Ile Ala Gln Asp Ile 
305                 310                 315                 320 


Arg Tyr Leu Gly Ser Gly Pro Arg Cys Gly Tyr His Glu Leu Met Leu 
                325                 330                 335     


Pro Glu Asn Glu Pro Gly Ser Ser Ile Met Pro Gly Lys Val Asn Pro 
            340                 345                 350         


Thr Gln Asn Glu Ala Leu Thr Gln Val Cys Val Gln Val Met Gly Asn 
        355                 360                 365             


Asn Ala Ala Ile Thr Phe Ala Gly Ser Gln Gly Gln Phe Glu Leu Asn 
    370                 375                 380                 


Val Phe Lys Pro Val Met Ile Ala Asn Leu Leu Asn Ser Ile Arg Leu 
385                 390                 395                 400 


Ile Thr Asp Ala Ala Tyr Ser Phe Arg Val His Cys Val Glu Gly Ile 
                405                 410                 415     


Lys Ala Asn Glu Pro Arg Ile His Glu Leu Leu Thr Lys Ser Leu Met 
            420                 425                 430         


Leu Val Thr Ala Leu Asn Pro Lys Ile Gly Tyr Asp Ala Ala Ser Lys 
        435                 440                 445             


Val Ala Lys Asn Ala His Lys Lys Gly Ile Thr Leu Lys Glu Ser Ala 
    450                 455                 460                 


Leu Glu Leu Gly Val Leu Thr Glu Lys Glu Phe Asp Glu Trp Val Val 
465                 470                 475                 480 


Pro Glu His Met Leu Gly Pro Lys 
                485             


<210>  15
<211>  343
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Val Lys Val Ala Ile Leu Gly Ala Ser Gly Gly Val Gly Gln Pro 
1               5                   10                  15      


Leu Ser Leu Leu Leu Lys Leu Ser Pro Tyr Val Ser Glu Leu Ala Leu 
            20                  25                  30          


Tyr Asp Ile Arg Ala Ala Glu Gly Ile Gly Lys Asp Leu Ser His Ile 
        35                  40                  45              


Asn Thr Asn Ser Ser Cys Val Gly Tyr Asp Lys Asp Ser Ile Glu Asn 
    50                  55                  60                  


Thr Leu Ser Asn Ala Gln Val Val Leu Ile Pro Ala Gly Val Pro Arg 
65                  70                  75                  80  


Lys Pro Gly Leu Thr Arg Asp Asp Leu Phe Lys Met Asn Ala Gly Ile 
                85                  90                  95      


Val Lys Ser Leu Val Thr Ala Val Gly Lys Phe Ala Pro Asn Ala Arg 
            100                 105                 110         


Ile Leu Val Ile Ser Asn Pro Val Asn Ser Leu Val Pro Ile Ala Val 
        115                 120                 125             


Glu Thr Leu Lys Lys Met Gly Lys Phe Lys Pro Gly Asn Val Met Gly 
    130                 135                 140                 


Val Thr Asn Leu Asp Leu Val Arg Ala Glu Thr Phe Leu Val Asp Tyr 
145                 150                 155                 160 


Leu Met Leu Lys Asn Pro Lys Ile Gly Gln Glu Gln Asp Lys Thr Thr 
                165                 170                 175     


Met His Arg Lys Val Thr Val Ile Gly Gly His Ser Gly Glu Thr Ile 
            180                 185                 190         


Ile Pro Ile Ile Thr Asp Lys Ser Leu Val Phe Gln Leu Asp Lys Gln 
        195                 200                 205             


Tyr Glu His Phe Ile His Arg Val Gln Phe Gly Gly Asp Glu Ile Val 
    210                 215                 220                 


Lys Ala Lys Gln Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Phe Ala 
225                 230                 235                 240 


Gly Ala Lys Phe Ala Glu Glu Val Leu Arg Ser Phe His Asn Glu Lys 
                245                 250                 255     


Pro Glu Thr Glu Ser Leu Ser Ala Phe Val Tyr Leu Pro Gly Leu Lys 
            260                 265                 270         


Asn Gly Lys Lys Ala Gln Gln Leu Val Gly Asp Asn Ser Ile Glu Tyr 
        275                 280                 285             


Phe Ser Leu Pro Ile Val Leu Arg Asn Gly Ser Val Val Ser Ile Asp 
    290                 295                 300                 


Thr Ser Val Leu Glu Lys Leu Ser Pro Arg Glu Glu Gln Leu Val Asn 
305                 310                 315                 320 


Thr Ala Val Lys Glu Leu Arg Lys Asn Ile Glu Lys Gly Lys Ser Phe 
                325                 330                 335     


Ile Leu Asp Ser Ser Lys Leu 
            340             


<210>  16
<211>  377
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  16

Met Pro His Ser Val Thr Pro Ser Ile Glu Gln Asp Ser Leu Lys Ile 
1               5                   10                  15      


Ala Ile Leu Gly Ala Ala Gly Gly Ile Gly Gln Ser Leu Ser Leu Leu 
            20                  25                  30          


Leu Lys Ala Gln Leu Gln Tyr Gln Leu Lys Glu Ser Asn Arg Ser Val 
        35                  40                  45              


Thr His Ile His Leu Ala Leu Tyr Asp Val Asn Gln Glu Ala Ile Asn 
    50                  55                  60                  


Gly Val Thr Ala Asp Leu Ser His Ile Asp Thr Pro Ile Ser Val Ser 
65                  70                  75                  80  


Ser His Ser Pro Ala Gly Gly Ile Glu Asn Cys Leu His Asn Ala Ser 
                85                  90                  95      


Ile Val Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg 
            100                 105                 110         


Asp Asp Leu Phe Asn Val Asn Ala Gly Ile Ile Ser Gln Leu Gly Asp 
        115                 120                 125             


Ser Ile Ala Glu Cys Cys Asp Leu Ser Lys Val Phe Val Leu Val Ile 
    130                 135                 140                 


Ser Asn Pro Val Asn Ser Leu Val Pro Val Met Val Ser Asn Ile Leu 
145                 150                 155                 160 


Lys Asn His Pro Gln Ser Arg Asn Ser Gly Ile Glu Arg Arg Ile Met 
                165                 170                 175     


Gly Val Thr Lys Leu Asp Ile Val Arg Ala Ser Thr Phe Leu Arg Glu 
            180                 185                 190         


Ile Asn Ile Glu Ser Gly Leu Thr Pro Arg Val Asn Ser Met Pro Asp 
        195                 200                 205             


Val Pro Val Ile Gly Gly His Ser Gly Glu Thr Ile Ile Pro Leu Phe 
    210                 215                 220                 


Ser Gln Ser Asn Phe Leu Ser Arg Leu Asn Glu Asp Gln Leu Lys Tyr 
225                 230                 235                 240 


Leu Ile His Arg Val Gln Tyr Gly Gly Asp Glu Val Val Lys Ala Lys 
                245                 250                 255     


Asn Gly Lys Gly Ser Ala Thr Leu Ser Met Ala His Ala Gly Tyr Lys 
            260                 265                 270         


Cys Val Val Gln Phe Val Ser Leu Leu Leu Gly Asn Ile Glu Gln Ile 
        275                 280                 285             


His Gly Thr Tyr Tyr Val Pro Leu Lys Asp Ala Asn Asn Phe Pro Ile 
    290                 295                 300                 


Ala Pro Gly Ala Asp Gln Leu Leu Pro Leu Val Asp Gly Ala Asp Tyr 
305                 310                 315                 320 


Phe Ala Ile Pro Leu Thr Ile Thr Thr Lys Gly Val Ser Tyr Val Asp 
                325                 330                 335     


Tyr Asp Ile Val Asn Arg Met Asn Asp Met Glu Arg Asn Gln Met Leu 
            340                 345                 350         


Pro Ile Cys Val Ser Gln Leu Lys Lys Asn Ile Asp Lys Gly Leu Glu 
        355                 360                 365             


Phe Val Ala Ser Arg Ser Ala Ser Ser 
    370                 375         


<210>  17
<211>  334
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Leu Ser Arg Val Ala Lys Arg Ala Phe Ser Ser Thr Val Ala Asn 
1               5                   10                  15      


Pro Tyr Lys Val Thr Val Leu Gly Ala Gly Gly Gly Ile Gly Gln Pro 
            20                  25                  30          


Leu Ser Leu Leu Leu Lys Leu Asn His Lys Val Thr Asp Leu Arg Leu 
        35                  40                  45              


Tyr Asp Leu Lys Gly Ala Lys Gly Val Ala Thr Asp Leu Ser His Ile 
    50                  55                  60                  


Pro Thr Asn Ser Val Val Lys Gly Phe Thr Pro Glu Glu Pro Asp Gly 
65                  70                  75                  80  


Leu Asn Asn Ala Leu Lys Asp Thr Asp Met Val Leu Ile Pro Ala Gly 
                85                  90                  95      


Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp Leu Phe Ala Ile Asn 
            100                 105                 110         


Ala Ser Ile Val Arg Asp Leu Ala Ala Ala Thr Ala Glu Ser Ala Pro 
        115                 120                 125             


Asn Ala Ala Ile Leu Val Ile Ser Asn Pro Val Asn Ser Thr Val Pro 
    130                 135                 140                 


Ile Val Ala Gln Val Leu Lys Asn Lys Gly Val Tyr Asn Pro Lys Lys 
145                 150                 155                 160 


Leu Phe Gly Val Thr Thr Leu Asp Ser Ile Arg Ala Ala Arg Phe Ile 
                165                 170                 175     


Ser Glu Val Glu Asn Thr Asp Pro Thr Gln Glu Arg Val Asn Val Ile 
            180                 185                 190         


Gly Gly His Ser Gly Ile Thr Ile Ile Pro Leu Ile Ser Gln Thr Asn 
        195                 200                 205             


His Lys Leu Met Ser Asp Asp Lys Arg His Glu Leu Ile His Arg Ile 
    210                 215                 220                 


Gln Phe Gly Gly Asp Glu Val Val Lys Ala Lys Asn Gly Ala Gly Ser 
225                 230                 235                 240 


Ala Thr Leu Ser Met Ala His Ala Gly Ala Lys Phe Ala Asn Ala Val 
                245                 250                 255     


Leu Ser Gly Phe Lys Gly Glu Arg Asp Val Ile Glu Pro Ser Phe Val 
            260                 265                 270         


Asp Ser Pro Leu Phe Lys Ser Glu Gly Ile Glu Phe Phe Ala Ser Pro 
        275                 280                 285             


Val Thr Leu Gly Pro Asp Gly Ile Glu Lys Ile His Pro Ile Gly Glu 
    290                 295                 300                 


Leu Ser Ser Glu Glu Glu Glu Met Leu Gln Lys Cys Lys Glu Thr Leu 
305                 310                 315                 320 


Lys Lys Asn Ile Glu Lys Gly Val Asn Phe Val Ala Ser Lys 
                325                 330                 


<210>  18
<211>  1178
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  18

Met Ser Gln Arg Lys Phe Ala Gly Leu Arg Asp Asn Phe Asn Leu Leu 
1               5                   10                  15      


Gly Glu Lys Asn Lys Ile Leu Val Ala Asn Arg Gly Glu Ile Pro Ile 
            20                  25                  30          


Arg Ile Phe Arg Thr Ala His Glu Leu Ser Met Gln Thr Val Ala Ile 
        35                  40                  45              


Tyr Ser His Glu Asp Arg Leu Ser Thr His Lys Gln Lys Ala Asp Glu 
    50                  55                  60                  


Ala Tyr Val Ile Gly Glu Val Gly Gln Tyr Thr Pro Val Gly Ala Tyr 
65                  70                  75                  80  


Leu Ala Ile Asp Glu Ile Ile Ser Ile Ala Gln Lys His Gln Val Asp 
                85                  90                  95      


Phe Ile His Pro Gly Tyr Gly Phe Leu Ser Glu Asn Ser Glu Phe Ala 
            100                 105                 110         


Asp Lys Val Val Lys Ala Gly Ile Thr Trp Ile Gly Pro Pro Ala Glu 
        115                 120                 125             


Val Ile Asp Ser Val Gly Asp Lys Val Ser Ala Arg Asn Leu Ala Ala 
    130                 135                 140                 


Lys Ala Asn Val Pro Thr Val Pro Gly Thr Pro Gly Pro Ile Glu Thr 
145                 150                 155                 160 


Val Glu Glu Ala Leu Asp Phe Val Asn Glu Tyr Gly Tyr Pro Val Ile 
                165                 170                 175     


Ile Lys Ala Ala Phe Gly Gly Gly Gly Arg Gly Met Arg Val Val Arg 
            180                 185                 190         


Glu Gly Asp Asp Val Ala Asp Ala Phe Gln Arg Ala Thr Ser Glu Ala 
        195                 200                 205             


Arg Thr Ala Phe Gly Asn Gly Thr Cys Phe Val Glu Arg Phe Leu Asp 
    210                 215                 220                 


Lys Pro Lys His Ile Glu Val Gln Leu Leu Ala Asp Asn His Gly Asn 
225                 230                 235                 240 


Val Val His Leu Phe Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln 
                245                 250                 255     


Lys Val Val Glu Val Ala Pro Ala Lys Thr Leu Pro Arg Glu Val Arg 
            260                 265                 270         


Asp Ala Ile Leu Thr Asp Ala Val Lys Leu Ala Lys Glu Cys Gly Tyr 
        275                 280                 285             


Arg Asn Ala Gly Thr Ala Glu Phe Leu Val Asp Asn Gln Asn Arg His 
    290                 295                 300                 


Tyr Phe Ile Glu Ile Asn Pro Arg Ile Gln Val Glu His Thr Ile Thr 
305                 310                 315                 320 


Glu Glu Ile Thr Gly Ile Asp Ile Val Ala Ala Gln Ile Gln Ile Ala 
                325                 330                 335     


Ala Gly Ala Ser Leu Pro Gln Leu Gly Leu Phe Gln Asp Lys Ile Thr 
            340                 345                 350         


Thr Arg Gly Phe Ala Ile Gln Cys Arg Ile Thr Thr Glu Asp Pro Ala 
        355                 360                 365             


Lys Asn Phe Gln Pro Asp Thr Gly Arg Ile Glu Val Tyr Arg Ser Ala 
    370                 375                 380                 


Gly Gly Asn Gly Val Arg Leu Asp Gly Gly Asn Ala Tyr Ala Gly Thr 
385                 390                 395                 400 


Ile Ile Ser Pro His Tyr Asp Ser Met Leu Val Lys Cys Ser Cys Ser 
                405                 410                 415     


Gly Ser Thr Tyr Glu Ile Val Arg Arg Lys Met Ile Arg Ala Leu Ile 
            420                 425                 430         


Glu Phe Arg Ile Arg Gly Val Lys Thr Asn Ile Pro Phe Leu Leu Thr 
        435                 440                 445             


Leu Leu Thr Asn Pro Val Phe Ile Glu Gly Thr Tyr Trp Thr Thr Phe 
    450                 455                 460                 


Ile Asp Asp Thr Pro Gln Leu Phe Gln Met Val Ser Ser Gln Asn Arg 
465                 470                 475                 480 


Ala Gln Lys Leu Leu His Tyr Leu Ala Asp Val Ala Val Asn Gly Ser 
                485                 490                 495     


Ser Ile Lys Gly Gln Ile Gly Leu Pro Lys Leu Lys Ser Asn Pro Ser 
            500                 505                 510         


Val Pro His Leu His Asp Ala Gln Gly Asn Val Ile Asn Val Thr Lys 
        515                 520                 525             


Ser Ala Pro Pro Ser Gly Trp Arg Gln Val Leu Leu Glu Lys Gly Pro 
    530                 535                 540                 


Ala Glu Phe Ala Arg Gln Val Arg Gln Phe Asn Gly Thr Leu Leu Met 
545                 550                 555                 560 


Asp Thr Thr Trp Arg Asp Ala His Gln Ser Leu Leu Ala Thr Arg Val 
                565                 570                 575     


Arg Thr His Asp Leu Ala Thr Ile Ala Pro Thr Thr Ala His Ala Leu 
            580                 585                 590         


Ala Gly Arg Phe Ala Leu Glu Cys Trp Gly Gly Ala Thr Phe Asp Val 
        595                 600                 605             


Ala Met Arg Phe Leu His Glu Asp Pro Trp Glu Arg Leu Arg Lys Leu 
    610                 615                 620                 


Arg Ser Leu Val Pro Asn Ile Pro Phe Gln Met Leu Leu Arg Gly Ala 
625                 630                 635                 640 


Asn Gly Val Ala Tyr Ser Ser Leu Pro Asp Asn Ala Ile Asp His Phe 
                645                 650                 655     


Val Lys Gln Ala Lys Asp Asn Gly Val Asp Ile Phe Arg Val Phe Asp 
            660                 665                 670         


Ala Leu Asn Asp Leu Glu Gln Leu Lys Val Gly Val Asp Ala Val Lys 
        675                 680                 685             


Lys Ala Gly Gly Val Val Glu Ala Thr Val Cys Phe Ser Gly Asp Met 
    690                 695                 700                 


Leu Gln Pro Gly Lys Lys Tyr Asn Leu Asp Tyr Tyr Leu Glu Ile Ala 
705                 710                 715                 720 


Glu Lys Ile Val Gln Met Gly Thr His Ile Leu Gly Ile Lys Asp Met 
                725                 730                 735     


Ala Gly Thr Met Lys Pro Ala Ala Ala Lys Leu Leu Ile Gly Ser Leu 
            740                 745                 750         


Arg Ala Lys Tyr Pro Asp Leu Pro Ile His Val His Thr His Asp Ser 
        755                 760                 765             


Ala Gly Thr Ala Val Ala Ser Met Thr Ala Cys Ala Leu Ala Gly Ala 
    770                 775                 780                 


Asp Val Val Asp Val Ala Ile Asn Ser Met Ser Gly Leu Thr Ser Gln 
785                 790                 795                 800 


Pro Ser Ile Asn Ala Leu Leu Ala Ser Leu Glu Gly Asn Ile Asp Thr 
                805                 810                 815     


Gly Ile Asn Val Glu His Val Arg Glu Leu Asp Ala Tyr Trp Ala Glu 
            820                 825                 830         


Met Arg Leu Leu Tyr Ser Cys Phe Glu Ala Asp Leu Lys Gly Pro Asp 
        835                 840                 845             


Pro Glu Val Tyr Gln His Glu Ile Pro Gly Gly Gln Leu Thr Asn Leu 
    850                 855                 860                 


Leu Phe Gln Ala Gln Gln Leu Gly Leu Gly Glu Gln Trp Ala Glu Thr 
865                 870                 875                 880 


Lys Arg Ala Tyr Arg Glu Ala Asn Tyr Leu Leu Gly Asp Ile Val Lys 
                885                 890                 895     


Val Thr Pro Thr Ser Lys Val Val Gly Asp Leu Ala Gln Phe Met Val 
            900                 905                 910         


Ser Asn Lys Leu Thr Ser Asp Asp Val Arg Arg Leu Ala Asn Ser Leu 
        915                 920                 925             


Asp Phe Pro Asp Ser Val Met Asp Phe Phe Glu Gly Leu Ile Gly Gln 
    930                 935                 940                 


Pro Tyr Gly Gly Phe Pro Glu Pro Phe Arg Ser Asp Val Leu Arg Asn 
945                 950                 955                 960 


Lys Arg Arg Lys Leu Thr Cys Arg Pro Gly Leu Glu Leu Glu Pro Phe 
                965                 970                 975     


Asp Leu Glu Lys Ile Arg Glu Asp Leu Gln Asn Arg Phe Gly Asp Val 
            980                 985                 990         


Asp Glu Cys Asp Val Ala Ser Tyr  Asn Met Tyr Pro Arg  Val Tyr Glu 
        995                 1000                 1005             


Asp Phe  Gln Lys Met Arg Glu  Thr Tyr Gly Asp Leu  Ser Val Leu 
    1010                 1015                 1020             


Pro Thr  Arg Ser Phe Leu Ser  Pro Leu Glu Thr Asp  Glu Glu Ile 
    1025                 1030                 1035             


Glu Val  Val Ile Glu Gln Gly  Lys Thr Leu Ile Ile  Lys Leu Gln 
    1040                 1045                 1050             


Ala Val  Gly Asp Leu Asn Lys  Lys Thr Gly Glu Arg  Glu Val Tyr 
    1055                 1060                 1065             


Phe Asp  Leu Asn Gly Glu Met  Arg Lys Ile Arg Val  Ala Asp Arg 
    1070                 1075                 1080             


Ser Gln  Lys Val Glu Thr Val  Thr Lys Ser Lys Ala  Asp Met His 
    1085                 1090                 1095             


Asp Pro  Leu His Ile Gly Ala  Pro Met Ala Gly Val  Ile Val Glu 
    1100                 1105                 1110             


Val Lys  Val His Lys Gly Ser  Leu Ile Lys Lys Gly  Gln Pro Val 
    1115                 1120                 1125             


Ala Val  Leu Ser Ala Met Lys  Met Glu Met Ile Ile  Ser Ser Pro 
    1130                 1135                 1140             


Ser Asp  Gly Gln Val Lys Glu  Val Phe Val Ser Asp  Gly Glu Asn 
    1145                 1150                 1155             


Val Asp  Ser Ser Asp Leu Leu  Val Leu Leu Glu Asp  Gln Val Pro 
    1160                 1165                 1170             


Val Glu  Thr Lys Ala 
    1175             


<210>  19
<211>  1180
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Met Ser Ser Ser Lys Lys Leu Ala Gly Leu Arg Asp Asn Phe Ser Leu 
1               5                   10                  15      


Leu Gly Glu Lys Asn Lys Ile Leu Val Ala Asn Arg Gly Glu Ile Pro 
            20                  25                  30          


Ile Arg Ile Phe Arg Ser Ala His Glu Leu Ser Met Arg Thr Ile Ala 
        35                  40                  45              


Ile Tyr Ser His Glu Asp Arg Leu Ser Met His Arg Leu Lys Ala Asp 
    50                  55                  60                  


Glu Ala Tyr Val Ile Gly Glu Glu Gly Gln Tyr Thr Pro Val Gly Ala 
65                  70                  75                  80  


Tyr Leu Ala Met Asp Glu Ile Ile Glu Ile Ala Lys Lys His Lys Val 
                85                  90                  95      


Asp Phe Ile His Pro Gly Tyr Gly Phe Leu Ser Glu Asn Ser Glu Phe 
            100                 105                 110         


Ala Asp Lys Val Val Lys Ala Gly Ile Thr Trp Ile Gly Pro Pro Ala 
        115                 120                 125             


Glu Val Ile Asp Ser Val Gly Asp Lys Val Ser Ala Arg His Leu Ala 
    130                 135                 140                 


Ala Arg Ala Asn Val Pro Thr Val Pro Gly Thr Pro Gly Pro Ile Glu 
145                 150                 155                 160 


Thr Val Gln Glu Ala Leu Asp Phe Val Asn Glu Tyr Gly Tyr Pro Val 
                165                 170                 175     


Ile Ile Lys Ala Ala Phe Gly Gly Gly Gly Arg Gly Met Arg Val Val 
            180                 185                 190         


Arg Glu Gly Asp Asp Val Ala Asp Ala Phe Gln Arg Ala Thr Ser Glu 
        195                 200                 205             


Ala Arg Thr Ala Phe Gly Asn Gly Thr Cys Phe Val Glu Arg Phe Leu 
    210                 215                 220                 


Asp Lys Pro Lys His Ile Glu Val Gln Leu Leu Ala Asp Asn His Gly 
225                 230                 235                 240 


Asn Val Val His Leu Phe Glu Arg Asp Cys Ser Val Gln Arg Arg His 
                245                 250                 255     


Gln Lys Val Val Glu Val Ala Pro Ala Lys Thr Leu Pro Arg Glu Val 
            260                 265                 270         


Arg Asp Ala Ile Leu Thr Asp Ala Val Lys Leu Ala Lys Val Cys Gly 
        275                 280                 285             


Tyr Arg Asn Ala Gly Thr Ala Glu Phe Leu Val Asp Asn Gln Asn Arg 
    290                 295                 300                 


His Tyr Phe Ile Glu Ile Asn Pro Arg Ile Gln Val Glu His Thr Ile 
305                 310                 315                 320 


Thr Glu Glu Ile Thr Gly Ile Asp Ile Val Ser Ala Gln Ile Gln Ile 
                325                 330                 335     


Ala Ala Gly Ala Thr Leu Thr Gln Leu Gly Leu Leu Gln Asp Lys Ile 
            340                 345                 350         


Thr Thr Arg Gly Phe Ser Ile Gln Cys Arg Ile Thr Thr Glu Asp Pro 
        355                 360                 365             


Ser Lys Asn Phe Gln Pro Asp Thr Gly Arg Leu Glu Val Tyr Arg Ser 
    370                 375                 380                 


Ala Gly Gly Asn Gly Val Arg Leu Asp Gly Gly Asn Ala Tyr Ala Gly 
385                 390                 395                 400 


Ala Thr Ile Ser Pro His Tyr Asp Ser Met Leu Val Lys Cys Ser Cys 
                405                 410                 415     


Ser Gly Ser Thr Tyr Glu Ile Val Arg Arg Lys Met Ile Arg Ala Leu 
            420                 425                 430         


Ile Glu Phe Arg Ile Arg Gly Val Lys Thr Asn Ile Pro Phe Leu Leu 
        435                 440                 445             


Thr Leu Leu Thr Asn Pro Val Phe Ile Glu Gly Thr Tyr Trp Thr Thr 
    450                 455                 460                 


Phe Ile Asp Asp Thr Pro Gln Leu Phe Gln Met Val Ser Ser Gln Asn 
465                 470                 475                 480 


Arg Ala Gln Lys Leu Leu His Tyr Leu Ala Asp Leu Ala Val Asn Gly 
                485                 490                 495     


Ser Ser Ile Lys Gly Gln Ile Gly Leu Pro Lys Leu Lys Ser Asn Pro 
            500                 505                 510         


Ser Val Pro His Leu His Asp Ala Gln Gly Asn Val Ile Asn Val Thr 
        515                 520                 525             


Lys Ser Ala Pro Pro Ser Gly Trp Arg Gln Val Leu Leu Glu Lys Gly 
    530                 535                 540                 


Pro Ser Glu Phe Ala Lys Gln Val Arg Gln Phe Asn Gly Thr Leu Leu 
545                 550                 555                 560 


Met Asp Thr Thr Trp Arg Asp Ala His Gln Ser Leu Leu Ala Thr Arg 
                565                 570                 575     


Val Arg Thr His Asp Leu Ala Thr Ile Ala Pro Thr Thr Ala His Ala 
            580                 585                 590         


Leu Ala Gly Ala Phe Ala Leu Glu Cys Trp Gly Gly Ala Thr Phe Asp 
        595                 600                 605             


Val Ala Met Arg Phe Leu His Glu Asp Pro Trp Glu Arg Leu Arg Lys 
    610                 615                 620                 


Leu Arg Ser Leu Val Pro Asn Ile Pro Phe Gln Met Leu Leu Arg Gly 
625                 630                 635                 640 


Ala Asn Gly Val Ala Tyr Ser Ser Leu Pro Asp Asn Ala Ile Asp His 
                645                 650                 655     


Phe Val Lys Gln Ala Lys Asp Asn Gly Val Asp Ile Phe Arg Val Phe 
            660                 665                 670         


Asp Ala Leu Asn Asp Leu Glu Gln Leu Lys Val Gly Val Asn Ala Val 
        675                 680                 685             


Lys Lys Ala Gly Gly Val Val Glu Ala Thr Val Cys Tyr Ser Gly Asp 
    690                 695                 700                 


Met Leu Gln Pro Gly Lys Lys Tyr Asn Leu Asp Tyr Tyr Leu Glu Val 
705                 710                 715                 720 


Val Glu Lys Ile Val Gln Met Gly Thr His Ile Leu Gly Ile Lys Asp 
                725                 730                 735     


Met Ala Gly Thr Met Lys Pro Ala Ala Ala Lys Leu Leu Ile Gly Ser 
            740                 745                 750         


Leu Arg Thr Arg Tyr Pro Asp Leu Pro Ile His Val His Ser His Asp 
        755                 760                 765             


Ser Ala Gly Thr Ala Val Ala Ser Met Thr Ala Cys Ala Leu Ala Gly 
    770                 775                 780                 


Ala Asp Val Val Asp Val Ala Ile Asn Ser Met Ser Gly Leu Thr Ser 
785                 790                 795                 800 


Gln Pro Ser Ile Asn Ala Leu Leu Ala Ser Leu Glu Gly Asn Ile Asp 
                805                 810                 815     


Thr Gly Ile Asn Val Glu His Val Arg Glu Leu Asp Ala Tyr Trp Ala 
            820                 825                 830         


Glu Met Arg Leu Leu Tyr Ser Cys Phe Glu Ala Asp Leu Lys Gly Pro 
        835                 840                 845             


Asp Pro Glu Val Tyr Gln His Glu Ile Pro Gly Gly Gln Leu Thr Asn 
    850                 855                 860                 


Leu Leu Phe Gln Ala Gln Gln Leu Gly Leu Gly Glu Gln Trp Ala Glu 
865                 870                 875                 880 


Thr Lys Arg Ala Tyr Arg Glu Ala Asn Tyr Leu Leu Gly Asp Ile Val 
                885                 890                 895     


Lys Val Thr Pro Thr Ser Lys Val Val Gly Asp Leu Ala Gln Phe Met 
            900                 905                 910         


Val Ser Asn Lys Leu Thr Ser Asp Asp Ile Arg Arg Leu Ala Asn Ser 
        915                 920                 925             


Leu Asp Phe Pro Asp Ser Val Met Asp Phe Phe Glu Gly Leu Ile Gly 
    930                 935                 940                 


Gln Pro Tyr Gly Gly Phe Pro Glu Pro Leu Arg Ser Asp Val Leu Arg 
945                 950                 955                 960 


Asn Lys Arg Arg Lys Leu Thr Cys Arg Pro Gly Leu Glu Leu Glu Pro 
                965                 970                 975     


Phe Asp Leu Glu Lys Ile Arg Glu Asp Leu Gln Asn Arg Phe Gly Asp 
            980                 985                 990         


Ile Asp Glu Cys Asp Val Ala Ser  Tyr Asn Met Tyr Pro  Arg Val Tyr 
        995                 1000                 1005             


Glu Asp  Phe Gln Lys Ile Arg  Glu Thr Tyr Gly Asp  Leu Ser Val 
    1010                 1015                 1020             


Leu Pro  Thr Lys Asn Phe Leu  Ala Pro Ala Glu Pro  Asp Glu Glu 
    1025                 1030                 1035             


Ile Glu  Val Thr Ile Glu Gln  Gly Lys Thr Leu Ile  Ile Lys Leu 
    1040                 1045                 1050             


Gln Ala  Val Gly Asp Leu Asn  Lys Lys Thr Gly Gln  Arg Glu Val 
    1055                 1060                 1065             


Tyr Phe  Glu Leu Asn Gly Glu  Leu Arg Lys Ile Arg  Val Ala Asp 
    1070                 1075                 1080             


Lys Ser  Gln Asn Ile Gln Ser  Val Ala Lys Pro Lys  Ala Asp Val 
    1085                 1090                 1095             


His Asp  Thr His Gln Ile Gly  Ala Pro Met Ala Gly  Val Ile Ile 
    1100                 1105                 1110             


Glu Val  Lys Val His Lys Gly  Ser Leu Val Lys Lys  Gly Glu Ser 
    1115                 1120                 1125             


Ile Ala  Val Leu Ser Ala Met  Lys Met Glu Met Val  Val Ser Ser 
    1130                 1135                 1140             


Pro Ala  Asp Gly Gln Val Lys  Asp Val Phe Ile Lys  Asp Gly Glu 
    1145                 1150                 1155             


Ser Val  Asp Ala Ser Asp Leu  Leu Val Val Leu Glu  Glu Glu Thr 
    1160                 1165                 1170             


Leu Pro  Pro Ser Gln Lys Lys  
    1175                 1180 


<210>  20
<211>  446
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  20

Met Lys Ile Val Val Ile Gly Thr Asn His Ala Gly Ile Ala Thr Ala 
1               5                   10                  15      


Asn Thr Leu Leu Glu Gln Tyr Pro Gly His Glu Ile Val Met Ile Asp 
            20                  25                  30          


Arg Asn Ser Asn Met Ser Tyr Leu Gly Cys Gly Thr Ala Ile Trp Val 
        35                  40                  45              


Gly Arg Gln Ile Glu Lys Pro Asp Glu Leu Phe Tyr Ala Lys Ala Glu 
    50                  55                  60                  


Asp Phe Glu Ala Lys Gly Val Lys Ile Leu Thr Glu Thr Glu Val Ser 
65                  70                  75                  80  


Glu Ile Asp Phe Ala Asn Lys Lys Val Tyr Ala Lys Thr Lys Ser Asp 
                85                  90                  95      


Asp Glu Ile Ile Glu Ala Tyr Asp Lys Leu Val Leu Ala Thr Gly Ser 
            100                 105                 110         


Arg Pro Ile Ile Pro Asn Leu Pro Gly Lys Asp Leu Lys Gly Ile His 
        115                 120                 125             


Phe Leu Lys Leu Phe Gln Glu Gly Gln Ala Ile Asp Ala Glu Phe Ala 
    130                 135                 140                 


Lys Glu Lys Val Lys Arg Ile Ala Val Ile Gly Ala Gly Tyr Ile Gly 
145                 150                 155                 160 


Thr Glu Ile Ala Glu Ala Ala Lys Arg Arg Gly Lys Glu Val Leu Leu 
                165                 170                 175     


Phe Asp Ala Glu Asn Thr Ser Leu Ala Ser Tyr Tyr Asp Glu Glu Phe 
            180                 185                 190         


Ala Lys Gly Met Asp Glu Asn Leu Ala Gln His Gly Ile Glu Leu His 
        195                 200                 205             


Phe Gly Glu Leu Ala Lys Glu Phe Lys Ala Asn Glu Glu Gly Tyr Val 
    210                 215                 220                 


Ser Gln Ile Val Thr Asn Lys Ala Thr Tyr Asp Val Asp Leu Val Ile 
225                 230                 235                 240 


Asn Cys Ile Gly Phe Thr Ala Asn Ser Ala Leu Ala Ser Asp Lys Leu 
                245                 250                 255     


Ala Thr Phe Lys Asn Gly Ala Ile Lys Val Asp Lys His Gln Gln Ser 
            260                 265                 270         


Ser Asp Pro Asp Val Tyr Ala Val Gly Asp Val Ala Thr Ile Tyr Ser 
        275                 280                 285             


Asn Ala Leu Gln Asp Phe Thr Tyr Ile Ala Leu Ala Ser Asn Ala Val 
    290                 295                 300                 


Arg Ser Gly Ile Val Ala Gly His Asn Ile Gly Gly Lys Glu Leu Glu 
305                 310                 315                 320 


Ser Val Gly Val Gln Gly Ser Asn Gly Ile Ser Ile Phe Gly Tyr Asn 
                325                 330                 335     


Met Thr Ser Thr Gly Leu Ser Val Lys Ala Ala Lys Lys Leu Gly Leu 
            340                 345                 350         


Glu Val Ser Phe Ser Asp Phe Glu Asp Lys Gln Lys Ala Trp Phe Leu 
        355                 360                 365             


His Glu Asn Asn Asp Ser Val Lys Ile Arg Ile Val Tyr Glu Thr Lys 
    370                 375                 380                 


Ser Arg Arg Ile Ile Gly Ala Gln Leu Ala Ser Lys Ser Glu Ile Ile 
385                 390                 395                 400 


Ala Gly Asn Ile Asn Met Phe Ser Leu Ala Ile Gln Glu Lys Lys Thr 
                405                 410                 415     


Ile Asp Glu Leu Ala Leu Leu Asp Leu Phe Phe Leu Pro His Phe Asn 
            420                 425                 430         


Ser Pro Tyr Asn Tyr Met Thr Val Ala Ala Leu Asn Ala Lys 
        435                 440                 445     


<210>  21
<211>  356
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  21

Met Tyr Pro Thr Ser Gly Cys Ala Arg Val Leu Met Ala Cys Pro Ala 
1               5                   10                  15      


Pro Ala Met Leu Arg Gly Pro Leu Leu Arg Pro Ser Thr Thr Ala Ile 
            20                  25                  30          


Arg Gly Leu Arg Gly Ser Pro Leu Leu Tyr His Tyr Ala Ala Thr Ser 
        35                  40                  45              


Asn Ser Asn Met Arg Tyr Phe Ser Ser Thr Ser Arg Arg Trp Ile Lys 
    50                  55                  60                  


Glu Phe Phe Ala Pro Pro Lys Glu Thr Asp His Ile Val Glu Ser Val 
65                  70                  75                  80  


Thr Thr Trp Lys His Pro Val Phe Thr Glu Lys Gln Met Lys Glu Ile 
                85                  90                  95      


Ala Ile Ala His Arg Glu Ala Lys Asn Trp Ser Asp Trp Val Ala Leu 
            100                 105                 110         


Gly Thr Val Arg Phe Leu Arg Trp Ala Thr Asp Leu Ala Thr Gly Tyr 
        115                 120                 125             


Arg His Ala Ala Pro Gly Lys Gln Gly Val Glu Val Pro Glu Gln Phe 
    130                 135                 140                 


Gln Met Thr Glu Arg Lys Trp Val Ile Arg Phe Ile Phe Leu Glu Thr 
145                 150                 155                 160 


Val Ala Gly Val Pro Gly Met Val Gly Gly Met Leu Arg His Leu Arg 
                165                 170                 175     


Ser Leu Arg Arg Met Lys Arg Asp Asn Gly Trp Ile Glu Thr Leu Leu 
            180                 185                 190         


Glu Glu Ala Tyr Asn Glu Arg Met His Leu Leu Ser Phe Leu Lys Leu 
        195                 200                 205             


Ala Gln Pro Gly Trp Phe Met Arg Leu Met Val Leu Gly Ala Gln Gly 
    210                 215                 220                 


Val Phe Phe Asn Gly Phe Phe Ile Ser Tyr Leu Ile Ser Pro Arg Thr 
225                 230                 235                 240 


Cys His Arg Phe Val Gly Tyr Leu Glu Glu Glu Ala Val Met Thr Tyr 
                245                 250                 255     


Thr His Ala Ile Lys Asp Leu Glu Ser Gly Lys Leu Pro Asn Trp Ala 
            260                 265                 270         


Asn Gln Pro Ala Pro Asp Ile Ala Val Ala Tyr Trp Gln Met Pro Glu 
        275                 280                 285             


Gly Lys Arg Thr Ile Leu Asp Leu Leu Tyr Tyr Ile Arg Ala Asp Glu 
    290                 295                 300                 


Ala Lys His Arg Glu Val Asn His Thr Leu Ala Asn Leu Lys Gln Gly 
305                 310                 315                 320 


Val Asp Pro Asn Pro Tyr Ala Ala Lys Tyr Asp Asn Pro Glu Ala Pro 
                325                 330                 335     


His Pro Thr Lys Ser Ala Glu Ile Val Lys Pro Thr Gly Trp Glu Arg 
            340                 345                 350         


Asp Glu Val Ile 
        355     


