                         SEQUENCE LISTING

<110>  Washington University
       IMAI, SHIN-ICHIRO
       YOSHIDA, MITSUKUNI
 
<120>  PRODUCTION AND USE OF EXTRACELLULAR VESICLE-CONTAINED ENAMPT

<130>  WSTL 19077.WO

<150>  US 62/858,483
<151>  2019-06-07

<150>  US 62/988,232
<151>  2020-03-11

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  491
<212>  PRT
<213>  Mus musculus

<400>  1

Met Asn Ala Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp 
1               5                   10                  15      


Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys 
            20                  25                  30          


Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys 
        35                  40                  45              


Val Arg Lys Val Lys Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr 
    50                  55                  60                  


Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile 
65                  70                  75                  80  


Gln Glu Ala Lys Glu Val Tyr Arg Glu His Phe Gln Asp Asp Val Phe 
                85                  90                  95      


Asn Glu Arg Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu 
            100                 105                 110         


Pro Ile Glu Val Lys Ala Val Pro Glu Gly Ser Val Ile Pro Arg Gly 
        115                 120                 125             


Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu 
    130                 135                 140                 


Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr 
145                 150                 155                 160 


Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu 
                165                 170                 175     


Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp 
            180                 185                 190         


Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala 
        195                 200                 205             


Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Ile 
    210                 215                 220                 


Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr 
225                 230                 235                 240 


Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp 
                245                 250                 255     


His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val 
            260                 265                 270         


Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu 
        275                 280                 285             


Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr 
    290                 295                 300                 


Glu Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr 
305                 310                 315                 320 


Val Leu Lys Val Leu Asp Ile Leu Gly Lys Lys Phe Pro Val Thr Glu 
                325                 330                 335     


Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln 
            340                 345                 350         


Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met 
        355                 360                 365             


Lys Gln Lys Lys Trp Ser Ile Glu Asn Val Ser Phe Gly Ser Gly Gly 
    370                 375                 380                 


Ala Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys 
385                 390                 395                 400 


Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Val Asn Val Phe Lys Asp 
                405                 410                 415     


Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu 
            420                 425                 430         


His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly 
        435                 440                 445             


Asp Leu Glu Glu Tyr Gly His Asp Leu Leu His Thr Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Val Arg Lys Asn Ala 
465                 470                 475                 480 


Gln Leu Asn Ile Glu Gln Asp Val Ala Pro His 
                485                 490     


<210>  2
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Pro Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp 
1               5                   10                  15      


Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys 
            20                  25                  30          


Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys 
        35                  40                  45              


Leu Arg Lys Val Lys Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr 
    50                  55                  60                  


Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile 
65                  70                  75                  80  


Gln Glu Ala Lys Asp Val Tyr Lys Glu His Phe Gln Asp Asp Val Phe 
                85                  90                  95      


Asn Glu Lys Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu 
            100                 105                 110         


Pro Ile Glu Ile Lys Ala Val Pro Glu Gly Phe Val Ile Pro Arg Gly 
        115                 120                 125             


Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu 
    130                 135                 140                 


Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr 
145                 150                 155                 160 


Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu 
                165                 170                 175     


Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp 
            180                 185                 190         


Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala 
        195                 200                 205             


Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Leu 
    210                 215                 220                 


Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr 
225                 230                 235                 240 


Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp 
                245                 250                 255     


His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val 
            260                 265                 270         


Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu 
        275                 280                 285             


Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr 
    290                 295                 300                 


Gln Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr 
305                 310                 315                 320 


Val Leu Lys Val Leu Glu Ile Leu Gly Lys Lys Phe Pro Val Thr Glu 
                325                 330                 335     


Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln 
            340                 345                 350         


Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met 
        355                 360                 365             


Lys Gln Lys Met Trp Ser Ile Glu Asn Ile Ala Phe Gly Ser Gly Gly 
    370                 375                 380                 


Gly Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys 
385                 390                 395                 400 


Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Ile Asn Val Phe Lys Asp 
                405                 410                 415     


Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu 
            420                 425                 430         


His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly 
        435                 440                 445             


Asp Leu Glu Glu Tyr Gly Gln Asp Leu Leu His Thr Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Ile Arg Lys Asn Ala 
465                 470                 475                 480 


Gln Leu Asn Ile Glu Leu Glu Ala Ala His His 
                485                 490     


<210>  3
<211>  491
<212>  PRT
<213>  Mus musculus

<400>  3

Met Asn Ala Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp 
1               5                   10                  15      


Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys 
            20                  25                  30          


Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys 
        35                  40                  45              


Val Arg Lys Val Arg Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr 
    50                  55                  60                  


Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile 
65                  70                  75                  80  


Gln Glu Ala Lys Glu Val Tyr Arg Glu His Phe Gln Asp Asp Val Phe 
                85                  90                  95      


Asn Glu Arg Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu 
            100                 105                 110         


Pro Ile Glu Val Lys Ala Val Pro Glu Gly Ser Val Ile Pro Arg Gly 
        115                 120                 125             


Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu 
    130                 135                 140                 


Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr 
145                 150                 155                 160 


Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu 
                165                 170                 175     


Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp 
            180                 185                 190         


Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala 
        195                 200                 205             


Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Ile 
    210                 215                 220                 


Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr 
225                 230                 235                 240 


Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp 
                245                 250                 255     


His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val 
            260                 265                 270         


Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu 
        275                 280                 285             


Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr 
    290                 295                 300                 


Glu Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr 
305                 310                 315                 320 


Val Leu Lys Val Leu Asp Ile Leu Gly Lys Lys Phe Pro Val Thr Glu 
                325                 330                 335     


Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln 
            340                 345                 350         


Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met 
        355                 360                 365             


Lys Gln Lys Lys Trp Ser Ile Glu Asn Val Ser Phe Gly Ser Gly Gly 
    370                 375                 380                 


Ala Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys 
385                 390                 395                 400 


Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Val Asn Val Phe Lys Asp 
                405                 410                 415     


Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu 
            420                 425                 430         


His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly 
        435                 440                 445             


Asp Leu Glu Glu Tyr Gly His Asp Leu Leu His Thr Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Val Arg Lys Asn Ala 
465                 470                 475                 480 


Gln Leu Asn Ile Glu Gln Asp Val Ala Pro His 
                485                 490     


<210>  4
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Pro Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp 
1               5                   10                  15      


Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys 
            20                  25                  30          


Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys 
        35                  40                  45              


Leu Arg Lys Val Arg Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr 
    50                  55                  60                  


Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile 
65                  70                  75                  80  


Gln Glu Ala Lys Asp Val Tyr Lys Glu His Phe Gln Asp Asp Val Phe 
                85                  90                  95      


Asn Glu Lys Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu 
            100                 105                 110         


Pro Ile Glu Ile Lys Ala Val Pro Glu Gly Phe Val Ile Pro Arg Gly 
        115                 120                 125             


Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu 
    130                 135                 140                 


Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr 
145                 150                 155                 160 


Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu 
                165                 170                 175     


Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp 
            180                 185                 190         


Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala 
        195                 200                 205             


Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Leu 
    210                 215                 220                 


Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr 
225                 230                 235                 240 


Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp 
                245                 250                 255     


His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val 
            260                 265                 270         


Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu 
        275                 280                 285             


Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr 
    290                 295                 300                 


Gln Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr 
305                 310                 315                 320 


Val Leu Lys Val Leu Glu Ile Leu Gly Lys Lys Phe Pro Val Thr Glu 
                325                 330                 335     


Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln 
            340                 345                 350         


Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met 
        355                 360                 365             


Lys Gln Lys Met Trp Ser Ile Glu Asn Ile Ala Phe Gly Ser Gly Gly 
    370                 375                 380                 


Gly Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys 
385                 390                 395                 400 


Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Ile Asn Val Phe Lys Asp 
                405                 410                 415     


Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu 
            420                 425                 430         


His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly 
        435                 440                 445             


Asp Leu Glu Glu Tyr Gly Gln Asp Leu Leu His Thr Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Ile Arg Lys Asn Ala 
465                 470                 475                 480 


Gln Leu Asn Ile Glu Leu Glu Ala Ala His His 
                485                 490     


<210>  5
<211>  491
<212>  PRT
<213>  Mus musculus

<400>  5

Met Asn Ala Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp 
1               5                   10                  15      


Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys 
            20                  25                  30          


Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys 
        35                  40                  45              


Val Arg Lys Val Gln Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr 
    50                  55                  60                  


Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile 
65                  70                  75                  80  


Gln Glu Ala Lys Glu Val Tyr Arg Glu His Phe Gln Asp Asp Val Phe 
                85                  90                  95      


Asn Glu Arg Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu 
            100                 105                 110         


Pro Ile Glu Val Lys Ala Val Pro Glu Gly Ser Val Ile Pro Arg Gly 
        115                 120                 125             


Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu 
    130                 135                 140                 


Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr 
145                 150                 155                 160 


Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu 
                165                 170                 175     


Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp 
            180                 185                 190         


Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala 
        195                 200                 205             


Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Ile 
    210                 215                 220                 


Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr 
225                 230                 235                 240 


Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp 
                245                 250                 255     


His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val 
            260                 265                 270         


Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu 
        275                 280                 285             


Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr 
    290                 295                 300                 


Glu Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr 
305                 310                 315                 320 


Val Leu Lys Val Leu Asp Ile Leu Gly Lys Lys Phe Pro Val Thr Glu 
                325                 330                 335     


Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln 
            340                 345                 350         


Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met 
        355                 360                 365             


Lys Gln Lys Lys Trp Ser Ile Glu Asn Val Ser Phe Gly Ser Gly Gly 
    370                 375                 380                 


Ala Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys 
385                 390                 395                 400 


Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Val Asn Val Phe Lys Asp 
                405                 410                 415     


Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu 
            420                 425                 430         


His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly 
        435                 440                 445             


Asp Leu Glu Glu Tyr Gly His Asp Leu Leu His Thr Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Val Arg Lys Asn Ala 
465                 470                 475                 480 


Gln Leu Asn Ile Glu Gln Asp Val Ala Pro His 
                485                 490     


<210>  6
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Pro Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp 
1               5                   10                  15      


Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys 
            20                  25                  30          


Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys 
        35                  40                  45              


Leu Arg Lys Val Gln Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr 
    50                  55                  60                  


Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile 
65                  70                  75                  80  


Gln Glu Ala Lys Asp Val Tyr Lys Glu His Phe Gln Asp Asp Val Phe 
                85                  90                  95      


Asn Glu Lys Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu 
            100                 105                 110         


Pro Ile Glu Ile Lys Ala Val Pro Glu Gly Phe Val Ile Pro Arg Gly 
        115                 120                 125             


Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu 
    130                 135                 140                 


Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr 
145                 150                 155                 160 


Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu 
                165                 170                 175     


Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp 
            180                 185                 190         


Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala 
        195                 200                 205             


Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Leu 
    210                 215                 220                 


Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr 
225                 230                 235                 240 


Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp 
                245                 250                 255     


His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val 
            260                 265                 270         


Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu 
        275                 280                 285             


Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr 
    290                 295                 300                 


Gln Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr 
305                 310                 315                 320 


Val Leu Lys Val Leu Glu Ile Leu Gly Lys Lys Phe Pro Val Thr Glu 
                325                 330                 335     


Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln 
            340                 345                 350         


Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met 
        355                 360                 365             


Lys Gln Lys Met Trp Ser Ile Glu Asn Ile Ala Phe Gly Ser Gly Gly 
    370                 375                 380                 


Gly Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys 
385                 390                 395                 400 


Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Ile Asn Val Phe Lys Asp 
                405                 410                 415     


Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu 
            420                 425                 430         


His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly 
        435                 440                 445             


Asp Leu Glu Glu Tyr Gly Gln Asp Leu Leu His Thr Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Ile Arg Lys Asn Ala 
465                 470                 475                 480 


Gln Leu Asn Ile Glu Leu Glu Ala Ala His His 
                485                 490     


