                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
       CRAIK, Charles  S.
       IVRY, Sam  L.
 
<120>  SYSTEMS COMPRISING SUBSTRATES AND METHODS OF USING THE SAME FOR 
       DETECTION OF PANCREATIC CANCERS

<130>  37944.0012P1

<140>  PCT/US2020/036702
<141>  2020-06-08

<150>  US 62/858,970
<151>  2019-06-07

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  1

Asp Glu Gly Trp Ala Leu Gln His 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  2

Val Gly Lys Trp Ser Tyr Arg Met 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  3

Asn Met Lys Trp Thr Arg Val Leu 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  4

Pro Trp Thr Trp Tyr Gly Val Lys 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  5

Phe Gly Ile Phe Tyr Leu Asn Gly 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  6

His Met Ile Ala Leu Tyr Trp Gly 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  7

Ile Lys Ile Leu Met Phe Tyr Trp 
1               5               


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  8

Gly Leu Tyr Phe Arg Tyr Glu 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  9

Ala Gly Phe Ser Leu Pro Ala 
1               5           


<210>  10
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg Tyr Asn Leu 
1               5                   10                  15      


Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser Gln Ala Cys 
            20                  25                  30          


Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu Ala Gln Phe 
        35                  40                  45              


Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser Val Ala Arg 
    50                  55                  60                  


Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu Ala Ser Leu 
65                  70                  75                  80  


Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser Thr Trp Val 
                85                  90                  95      


Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe Leu Gln Trp 
            100                 105                 110         


Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val His Thr Val 
        115                 120                 125             


Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr Ile Gln Arg 
    130                 135                 140                 


Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu Thr Leu Leu 
145                 150                 155                 160 


Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val Ser Gly Arg 
                165                 170                 175     


His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr Val Thr Thr 
            180                 185                 190         


Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr Asn Glu Ile 
        195                 200                 205             


Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe Pro Arg Pro 
    210                 215                 220                 


Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser Ser Pro His 
225                 230                 235                 240 


Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala Tyr Pro Asp 
                245                 250                 255     


Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn Arg Val Pro 
            260                 265                 270         


Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val Phe Gly Gly 
        275                 280                 285             


Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly Arg Pro Pro 
    290                 295                 300                 


Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly Ala Gly Leu 
305                 310                 315                 320 


Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp Glu Glu Val 
                325                 330                 335     


Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro Val Thr Gly 
            340                 345                 350         


Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu Leu Asn Pro 
        355                 360                 365             


<210>  11
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Lys Thr Leu Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu 
1               5                   10                  15      


Ala Gln Gly Ser Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu 
            20                  25                  30          


Lys Lys Lys Leu Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser 
        35                  40                  45              


His Asn Leu Asp Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln 
    50                  55                  60                  


Ser Ala Lys Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly 
65                  70                  75                  80  


Thr Ile Ser Ile Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro 
            100                 105                 110         


Ala Cys Lys Thr His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr 
        115                 120                 125             


Ser Gln Pro Gly Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu 
    130                 135                 140                 


Ser Gly Ile Ile Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val 
145                 150                 155                 160 


Val Gly Gln Gln Phe Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe 
                165                 170                 175     


Val Asp Ala Glu Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu 
            180                 185                 190         


Ala Val Gly Gly Val Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn 
        195                 200                 205             


Leu Val Asp Leu Pro Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu 
    210                 215                 220                 


Gly Gly Ala Gly Ser Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His 
225                 230                 235                 240 


Phe Ser Gly Ser Leu Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp 
                245                 250                 255     


Gln Ile Ala Leu Asp Asn Ile Gln Val Gly Gly Thr Val Met Phe Cys 
            260                 265                 270         


Ser Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Ile Thr 
        275                 280                 285             


Gly Pro Ser Asp Lys Ile Lys Gln Leu Gln Asn Ala Ile Gly Ala Ala 
    290                 295                 300                 


Pro Val Asp Gly Glu Tyr Ala Val Glu Cys Ala Asn Leu Asn Val Met 
305                 310                 315                 320 


Pro Asp Val Thr Phe Thr Ile Asn Gly Val Pro Tyr Thr Leu Ser Pro 
                325                 330                 335     


Thr Ala Tyr Thr Leu Leu Asp Phe Val Asp Gly Met Gln Phe Cys Ser 
            340                 345                 350         


Ser Gly Phe Gln Gly Leu Asp Ile His Pro Pro Ala Gly Pro Leu Trp 
        355                 360                 365             


Ile Leu Gly Asp Val Phe Ile Arg Gln Phe Tyr Ser Val Phe Asp Arg 
    370                 375                 380                 


Gly Asn Asn Arg Val Gly Leu Ala Pro Ala Val Pro 
385                 390                 395     


<210>  12
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Trp Met Val Val Val Leu Val Cys Leu Gln Leu Leu Glu Ala 
1               5                   10                  15      


Ala Val Val Lys Val Pro Leu Lys Lys Phe Lys Ser Ile Arg Glu Thr 
            20                  25                  30          


Met Lys Glu Lys Gly Leu Leu Gly Glu Phe Leu Arg Thr His Lys Tyr 
        35                  40                  45              


Asp Pro Ala Trp Lys Tyr Arg Phe Gly Asp Leu Ser Val Thr Tyr Glu 
    50                  55                  60                  


Pro Met Ala Tyr Met Asp Ala Ala Tyr Phe Gly Glu Ile Ser Ile Gly 
65                  70                  75                  80  


Thr Pro Pro Gln Asn Phe Leu Val Leu Phe Asp Thr Gly Ser Ser Asn 
                85                  90                  95      


Leu Trp Val Pro Ser Val Tyr Cys Gln Ser Gln Ala Cys Thr Ser His 
            100                 105                 110         


Ser Arg Phe Asn Pro Ser Glu Ser Ser Thr Tyr Ser Thr Asn Gly Gln 
        115                 120                 125             


Thr Phe Ser Leu Gln Tyr Gly Ser Gly Ser Leu Thr Gly Phe Phe Gly 
    130                 135                 140                 


Tyr Asp Thr Leu Thr Val Gln Ser Ile Gln Val Pro Asn Gln Glu Phe 
145                 150                 155                 160 


Gly Leu Ser Glu Asn Glu Pro Gly Thr Asn Phe Val Tyr Ala Gln Phe 
                165                 170                 175     


Asp Gly Ile Met Gly Leu Ala Tyr Pro Ala Leu Ser Val Asp Glu Ala 
            180                 185                 190         


Thr Thr Ala Met Gln Gly Met Val Gln Glu Gly Ala Leu Thr Ser Pro 
        195                 200                 205             


Val Phe Ser Val Tyr Leu Ser Asn Gln Gln Gly Ser Ser Gly Gly Ala 
    210                 215                 220                 


Val Val Phe Gly Gly Val Asp Ser Ser Leu Tyr Thr Gly Gln Ile Tyr 
225                 230                 235                 240 


Trp Ala Pro Val Thr Gln Glu Leu Tyr Trp Gln Ile Gly Ile Glu Glu 
                245                 250                 255     


Phe Leu Ile Gly Gly Gln Ala Ser Gly Trp Cys Ser Glu Gly Cys Gln 
            260                 265                 270         


Ala Ile Val Asp Thr Gly Thr Ser Leu Leu Thr Val Pro Gln Gln Tyr 
        275                 280                 285             


Met Ser Ala Leu Leu Gln Ala Thr Gly Ala Gln Glu Asp Glu Tyr Gly 
    290                 295                 300                 


Gln Phe Leu Val Asn Cys Asn Ser Ile Gln Asn Leu Pro Ser Leu Thr 
305                 310                 315                 320 


Phe Ile Ile Asn Gly Val Glu Phe Pro Leu Pro Pro Ser Ser Tyr Ile 
                325                 330                 335     


Leu Ser Asn Asn Gly Tyr Cys Thr Val Gly Val Glu Pro Thr Tyr Leu 
            340                 345                 350         


Ser Ser Gln Asn Gly Gln Pro Leu Trp Ile Leu Gly Asp Val Phe Leu 
        355                 360                 365             


Arg Ser Tyr Tyr Ser Val Tyr Asp Leu Gly Asn Asn Arg Val Gly Phe 
    370                 375                 380                 


Ala Thr Ala Ala 
385             


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Asp

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Glu, Phe, Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Gly, Asp, Met or Arg

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr, Phe, Trp, Leu or Met

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Tyr, Met, Leu, Ala, Phe or Ser

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu, Thr or Arg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Gln or Tyr

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is His

<400>  13

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Gly, Lys, Thr, Asp, Met, Ile, Leu, Ser or Arg, or a 
       modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Tyr, Phe, Ala, Trp, Leu, Tyr, Nle or Met, or a modified 
       amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Tyr, Met, Leu, Ala, Phe, Thr, Pro or Ser, or a modified 
       amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Leu, Tyr, Gly, Ala, Thr or Arg, or a modified amino acid 
       residue thereof

<400>  14

Xaa Xaa Xaa Xaa 
1               


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Nle

<400>  15

Arg Xaa Leu Phe Val 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  16

His Pro Phe Trp Ile 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Nle

<400>  17

Tyr Ala Xaa Tyr Xaa 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  18

Lys Phe Tyr Val Leu 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  19

Gln Tyr Trp Ile Trp 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  20

Phe Trp Glu Ala Phe 
1               5   


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  21

Ile Ile Asp Thr Tyr 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  22

Ala Val Gln Leu Ser 
1               5   


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Nle

<400>  23

Ser Thr Ala Xaa Thr 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  24

Glu Glu Asn Ser Ala 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  25

Thr Leu Arg Glu Arg 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  26

Val Ser Lys Asn Gln 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  27

Asn Gly Ser Asp His 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Nle

<400>  28

Xaa Gln His His Asn 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  29

Trp Lys Val Arg Lys 
1               5   


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  30

Leu Asn Ile Gln Glu 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  31

Gly Asp Thr Gly Asp 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  32

Asp Arg Gly Lys Gly 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  33

Pro His Pro Pro Pro 
1               5   


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Ala, Gly, His or Nle

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Asp or Gly

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Leu, Nle, Asp, Gln, Tyr, Phe, Trp, Pro or Gly

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr, Phe, Ile, Ala, Val, Gly, Arg or Pro

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Asp or Pro

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Tyr, Gly or Gln

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys, Gly, Arg, Trp or Gln

<400>  34

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa id Nle

<400>  35

Glu Ala Trp Xaa Thr Phe Ile 
1               5           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is lysine-fluorophore

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Nle

<400>  36

Xaa Ala Trp Xaa Thr Phe Ile 
1               5           


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is lysine-fluorophore

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Nle

<400>  37

Glu Xaa Trp Xaa Thr Phe Ile 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is lysine-fluorophore

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Nle

<400>  38

Glu Ala Xaa Xaa Thr Phe Ile 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  39

Ile Asn Asp Phe Leu Val Arg 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate

<400>  40

Gly Leu Tyr Phe Arg Tyr Glu 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is lysine-fluorophore

<400>  41

Xaa Leu Tyr Phe Arg Tyr Glu 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is lysine-fluorophore

<400>  42

Gly Xaa Tyr Phe Arg Tyr Glu 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is lysine-fluorophore

<400>  43

Gly Leu Xaa Phe Arg Tyr Glu 
1               5           


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is lysine-fluorophore

<400>  44

Ile Asn Xaa Phe Leu Val Arg 
1               5           


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is lysine-fluorophore

<400>  45

Xaa Asn Asp Phe Leu Val Arg 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is lysine-fluorophore

<400>  46

Ile Xaa Asp Phe Leu Val Arg 
1               5           


<210>  47

<400>  47
000

<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Asp, Ala, Val, Asn, Pro, Phe, His, Ile, Glu, Met, Trp, Lys
       or Gly, or a modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Glu, Phe, Gly, Asn, Met, Lys, Ala, Lys, Leu or Trp, or a 
       modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Gly, Phe, Lys, Asp, Met, Thr, Ile, Asn, Tyr, Trp, Leu or 
       Arg, or a modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr, Ala, Ser, Phe, Asn, Trp, Leu, Thr or Met, or a 
       modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Tyr, Met, Asn, Leu, Ala, Phe or Ser, or a modified amino 
       acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu, Thr or Arg, or a modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Gln or Tyr, or a modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is His, Met, Leu, Lys, Asn, Gly or Trp, or a modified amino 
       acid residue thereof

<400>  48

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Asp, Ala, Val, Asn, Pro, Phe, His, Ile, Glu, Met, Trp, Lys
       or Gly, or a modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Glu, Phe, Gly, Asn, Met, Lys, Ala, Lys, Leu or Trp, or a 
       modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Gly, Phe, Lys, Asp, Asn, Met, Thr, Ile, Tyr, Trp, Leu or 
       Arg, or a modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr, Ala, Ser, Phe, Trp, Asn, Leu, Thr or Met, or a 
       modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Tyr, Met, Asn, Leu, Ala, Phe or Ser, or a modified amino 
       acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu, Thr or Arg, or a modified amino acid residue thereof

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Gln or Tyr, or a modified amino acid residue thereof

<400>  49

Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


