                         SEQUENCE LISTING

<110>  Children's Medical Research Institute
 
<120>  Methods of treating cancer

<130>  187570PCT

<150>  AU2019902078
<151>  2019-06-14

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  1081
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Arg Arg Lys Gln Glu Gln Pro Lys Arg Leu Pro Ser His Val 
1               5                   10                  15      


Ser Arg Gln Glu Glu Ala Glu Gly Glu Leu Ser Glu Gly Glu His Trp 
            20                  25                  30          


Tyr Gly Asn Ser Ser Glu Thr Pro Ser Glu Ala Ser Tyr Gly Glu Val 
        35                  40                  45              


Gln Glu Asn Tyr Lys Leu Ser Leu Glu Asp Arg Ile Gln Glu Gln Ser 
    50                  55                  60                  


Thr Ser Pro Asp Thr Ser Leu Gly Ser Thr Thr Pro Ser Ser His Thr 
65                  70                  75                  80  


Leu Glu Leu Val Ala Leu Asp Ser Glu Val Leu Arg Asp Ser Leu Gln 
                85                  90                  95      


Cys Gln Asp His Leu Ser Pro Gly Val Ser Ser Leu Cys Asp Asp Asp 
            100                 105                 110         


Pro Gly Ser Asn Lys Pro Leu Ser Ser Asn Leu Arg Arg Leu Leu Glu 
        115                 120                 125             


Ala Gly Ser Leu Lys Leu Asp Ala Ala Ala Thr Ala Asn Gly Arg Val 
    130                 135                 140                 


Glu Ser Pro Val Asn Val Gly Ser Asn Leu Ser Phe Ser Pro Pro Ser 
145                 150                 155                 160 


His His Ala Gln Gln Leu Ser Val Leu Ala Arg Lys Leu Ala Glu Lys 
                165                 170                 175     


Gln Glu Gln Asn Asp Gln Tyr Thr Pro Ser Asn Arg Phe Ile Trp Asn 
            180                 185                 190         


Gln Gly Lys Trp Leu Pro Asn Ser Thr Thr Thr Cys Ser Leu Ser Pro 
        195                 200                 205             


Asp Ser Ala Ile Leu Lys Leu Lys Ala Ala Ala Asn Ala Val Leu Gln 
    210                 215                 220                 


Asp Lys Ser Leu Thr Arg Thr Glu Glu Thr Met Arg Phe Glu Ser Phe 
225                 230                 235                 240 


Ser Ser Pro Phe Ser Ser Gln Ser Ala Ser Ser Thr Leu Ala Ala Leu 
                245                 250                 255     


Ser Lys Lys Val Ser Glu Arg Ser Leu Thr Pro Gly Gln Glu His Pro 
            260                 265                 270         


Pro Pro Ala Ser Ser Phe Leu Ser Leu Ala Ser Met Thr Ser Ser Ala 
        275                 280                 285             


Ala Leu Leu Lys Glu Val Ala Ala Arg Ala Ala Gly Ser Leu Leu Ala 
    290                 295                 300                 


Glu Lys Ser Ser Leu Leu Pro Glu Asp Pro Leu Pro Pro Pro Pro Ser 
305                 310                 315                 320 


Glu Lys Lys Pro Glu Lys Val Thr Pro Pro Pro Pro Pro Pro Pro Pro 
                325                 330                 335     


Pro Pro Pro Pro Pro Pro Pro Gln Ser Leu Glu Leu Leu Leu Leu Pro 
            340                 345                 350         


Val Pro Lys Gly Arg Val Ser Lys Pro Ser Asn Ser Ala Ser Glu Glu 
        355                 360                 365             


Glu Ser Gly Lys Pro Phe Gln Cys Pro Ile Cys Gly Leu Val Ile Lys 
    370                 375                 380                 


Arg Lys Ser Tyr Trp Lys Arg His Met Val Ile His Thr Gly Leu Lys 
385                 390                 395                 400 


Ser His Gln Cys Pro Leu Cys Pro Phe Arg Cys Ala Arg Lys Asp Asn 
                405                 410                 415     


Leu Lys Ser His Met Lys Val His Gln His Gln Asp Arg Gly Glu Thr 
            420                 425                 430         


Phe Gln Cys Gln Leu Cys Pro Phe Thr Ser Ser Arg His Phe Ser Leu 
        435                 440                 445             


Lys Leu His Met Arg Cys His Gln His Phe Leu Arg Thr Glu Ala Lys 
    450                 455                 460                 


Val Lys Glu Glu Ile Pro Asp Pro Asp Val Lys Gly Ser Pro His Leu 
465                 470                 475                 480 


Ser Asp Ser Ala Cys Leu Gly Gln Gln Arg Glu Gly Gly Gly Thr Glu 
                485                 490                 495     


Leu Val Gly Thr Met Met Thr Ser Asn Thr Pro Glu Arg Thr Ser Gln 
            500                 505                 510         


Gly Gly Ala Gly Val Ser Pro Leu Leu Val Lys Glu Glu Pro Lys Glu 
        515                 520                 525             


Asp Asn Gly Leu Pro Thr Ser Phe Thr Leu Asn Ala Ala Asp Arg Pro 
    530                 535                 540                 


Ala Asn His Thr Lys Leu Lys Asp Pro Ser Glu Tyr Val Ala Asn Ser 
545                 550                 555                 560 


Ala Ser Ala Leu Phe Ser Gln Asp Ile Ser Val Lys Met Ala Ser Asp 
                565                 570                 575     


Phe Leu Met Lys Leu Ser Ala Ala Asn Gln Lys Glu Pro Met Asn Leu 
            580                 585                 590         


Asn Phe Lys Val Lys Glu Glu Pro Lys Glu Gly Glu Ser Leu Ser Thr 
        595                 600                 605             


Thr Leu Pro Arg Ser Ser Tyr Val Phe Ser Pro Glu Ser Glu Val Ser 
    610                 615                 620                 


Ala Pro Gly Val Ser Glu Asp Ala Leu Lys Pro Gln Glu Gly Lys Gly 
625                 630                 635                 640 


Ser Val Leu Arg Arg Asp Val Ser Val Lys Ala Ala Ser Glu Leu Leu 
                645                 650                 655     


Met Lys Leu Ser Ala Glu Ser Tyr Lys Glu Thr Gln Met Val Lys Ile 
            660                 665                 670         


Lys Glu Glu Pro Met Glu Val Asp Ile Gln Asp Ser His Val Ser Ile 
        675                 680                 685             


Ser Pro Ser Arg Asn Val Gly Tyr Ser Thr Leu Ile Gly Arg Glu Lys 
    690                 695                 700                 


Thr Glu Pro Leu Gln Lys Met Pro Glu Gly Arg Val Pro Pro Glu Arg 
705                 710                 715                 720 


Asn Leu Phe Ser Gln Asp Ile Ser Val Lys Met Ala Ser Glu Leu Leu 
                725                 730                 735     


Phe Gln Leu Ser Glu Lys Val Ser Lys Glu His Asn His Thr Lys Glu 
            740                 745                 750         


Asn Thr Ile Arg Thr Thr Thr Ser Pro Phe Phe Ser Glu Asp Thr Phe 
        755                 760                 765             


Arg Gln Ser Pro Phe Thr Ser Asn Ser Lys Glu Leu Leu Pro Ser Asp 
    770                 775                 780                 


Ser Val Leu His Gly Arg Ile Ser Ala Pro Glu Thr Glu Lys Ile Val 
785                 790                 795                 800 


Leu Glu Ala Gly Asn Gly Leu Pro Ser Trp Lys Phe Asn Asp Gln Leu 
                805                 810                 815     


Phe Pro Cys Asp Val Cys Gly Lys Val Phe Gly Arg Gln Gln Thr Leu 
            820                 825                 830         


Ser Arg His Leu Ser Leu His Thr Glu Glu Arg Lys Tyr Lys Cys His 
        835                 840                 845             


Leu Cys Pro Tyr Ala Ala Lys Cys Arg Ala Asn Leu Asn Gln His Leu 
    850                 855                 860                 


Thr Val His Ser Val Lys Leu Val Ser Thr Asp Thr Glu Asp Ile Val 
865                 870                 875                 880 


Ser Ala Val Thr Ser Glu Gly Ser Asp Gly Lys Lys His Pro Tyr Tyr 
                885                 890                 895     


Tyr Ser Cys His Val Cys Gly Phe Glu Thr Glu Leu Asn Val Gln Phe 
            900                 905                 910         


Val Ser His Met Ser Leu His Val Asp Lys Glu Gln Trp Met Phe Ser 
        915                 920                 925             


Ile Cys Cys Thr Ala Cys Asp Phe Val Thr Met Glu Glu Ala Glu Ile 
    930                 935                 940                 


Lys Thr His Ile Gly Thr Lys His Thr Gly Glu Asp Arg Lys Thr Pro 
945                 950                 955                 960 


Ser Glu Ser Asn Ser Pro Ser Ser Ser Ser Leu Ser Ala Leu Ser Asp 
                965                 970                 975     


Ser Ala Asn Ser Lys Asp Asp Ser Asp Gly Ser Gln Lys Asn Lys Gly 
            980                 985                 990         


Gly Asn Asn Leu Leu Val Ile Ser  Val Met Pro Gly Ser  Gln Pro Ser 
        995                 1000                 1005             


Leu Asn  Ser Glu Glu Lys Pro  Glu Lys Gly Phe Glu  Cys Val Phe 
    1010                 1015                 1020             


Cys Asn  Phe Val Cys Lys Thr  Lys Asn Met Phe Glu  Arg His Leu 
    1025                 1030                 1035             


Gln Ile  His Leu Ile Thr Arg  Met Phe Glu Cys Asp  Val Cys His 
    1040                 1045                 1050             


Lys Phe  Met Lys Thr Pro Glu  Gln Leu Leu Glu His  Lys Lys Cys 
    1055                 1060                 1065             


His Thr  Val Pro Thr Gly Gly  Leu Asn Ser Gly Gln  Trp 
    1070                 1075                 1080     


<210>  2
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Gly Gln Leu Ser Glu Gly Ala Ile Ala Ala Ile Met Gln Lys 
1               5                   10                  15      


Gly Asp Thr Asn Ile Lys Pro Ile Leu Gln Val Ile Asn Ile Arg Pro 
            20                  25                  30          


Ile Thr Thr Gly Asn Ser Pro Pro Arg Tyr Arg Leu Leu Met Ser Asp 
        35                  40                  45              


Gly Leu Asn Thr Leu Ser Ser Phe Met Leu Ala Thr Gln Leu Asn Pro 
    50                  55                  60                  


Leu Val Glu Glu Glu Gln Leu Ser Ser Asn Cys Val Cys Gln Ile His 
65                  70                  75                  80  


Arg Phe Ile Val Asn Thr Leu Lys Asp Gly Arg Arg Val Val Ile Leu 
                85                  90                  95      


Met Glu Leu Glu Val Leu Lys Ser Ala Glu Ala Val Gly Val Lys Ile 
            100                 105                 110         


Gly Asn Pro Val Pro Tyr Asn Glu Gly Leu Gly Gln Pro Gln Val Ala 
        115                 120                 125             


Pro Pro Ala Pro Ala Ala Ser Pro Ala Ala Ser Ser Arg Pro Gln Pro 
    130                 135                 140                 


Gln Asn Gly Ser Ser Gly Met Gly Ser Thr Val Ser Lys Ala Tyr Gly 
145                 150                 155                 160 


Ala Ser Lys Thr Phe Gly Lys Ala Ala Gly Pro Ser Leu Ser His Thr 
                165                 170                 175     


Ser Gly Gly Thr Gln Ser Lys Val Val Pro Ile Ala Ser Leu Thr Pro 
            180                 185                 190         


Tyr Gln Ser Lys Trp Thr Ile Cys Ala Arg Val Thr Asn Lys Ser Gln 
        195                 200                 205             


Ile Arg Thr Trp Ser Asn Ser Arg Gly Glu Gly Lys Leu Phe Ser Leu 
    210                 215                 220                 


Glu Leu Val Asp Glu Ser Gly Glu Ile Arg Ala Thr Ala Phe Asn Glu 
225                 230                 235                 240 


Gln Val Asp Lys Phe Phe Pro Leu Ile Glu Val Asn Lys Val Tyr Tyr 
                245                 250                 255     


Phe Ser Lys Gly Thr Leu Lys Ile Ala Asn Lys Gln Phe Thr Ala Val 
            260                 265                 270         


Lys Asn Asp Tyr Glu Met Thr Phe Asn Asn Glu Thr Ser Val Met Pro 
        275                 280                 285             


Cys Glu Asp Asp His His Leu Pro Thr Val Gln Phe Asp Phe Thr Gly 
    290                 295                 300                 


Ile Asp Asp Leu Glu Asn Lys Ser Lys Asp Ser Leu Val Asp Ile Ile 
305                 310                 315                 320 


Gly Ile Cys Lys Ser Tyr Glu Asp Ala Thr Lys Ile Thr Val Arg Ser 
                325                 330                 335     


Asn Asn Arg Glu Val Ala Lys Arg Asn Ile Tyr Leu Met Asp Thr Ser 
            340                 345                 350         


Gly Lys Val Val Thr Ala Thr Leu Trp Gly Glu Asp Ala Asp Lys Phe 
        355                 360                 365             


Asp Gly Ser Arg Gln Pro Val Leu Ala Ile Lys Gly Ala Arg Val Ser 
    370                 375                 380                 


Asp Phe Gly Gly Arg Ser Leu Ser Val Leu Ser Ser Ser Thr Ile Ile 
385                 390                 395                 400 


Ala Asn Pro Asp Ile Pro Glu Ala Tyr Lys Leu Arg Gly Trp Phe Asp 
                405                 410                 415     


Ala Glu Gly Gln Ala Leu Asp Gly Val Ser Ile Ser Asp Leu Lys Ser 
            420                 425                 430         


Gly Gly Val Gly Gly Ser Asn Thr Asn Trp Lys Thr Leu Tyr Glu Val 
        435                 440                 445             


Lys Ser Glu Asn Leu Gly Gln Gly Asp Lys Pro Asp Tyr Phe Ser Ser 
    450                 455                 460                 


Val Ala Thr Val Val Tyr Leu Arg Lys Glu Asn Cys Met Tyr Gln Ala 
465                 470                 475                 480 


Cys Pro Thr Gln Asp Cys Asn Lys Lys Val Ile Asp Gln Gln Asn Gly 
                485                 490                 495     


Leu Tyr Arg Cys Glu Lys Cys Asp Thr Glu Phe Pro Asn Phe Lys Tyr 
            500                 505                 510         


Arg Met Ile Leu Ser Val Asn Ile Ala Asp Phe Gln Glu Asn Gln Trp 
        515                 520                 525             


Val Thr Cys Phe Gln Glu Ser Ala Glu Ala Ile Leu Gly Gln Asn Ala 
    530                 535                 540                 


Ala Tyr Leu Gly Glu Leu Lys Asp Lys Asn Glu Gln Ala Phe Glu Glu 
545                 550                 555                 560 


Val Phe Gln Asn Ala Asn Phe Arg Ser Phe Ile Phe Arg Val Arg Val 
                565                 570                 575     


Lys Val Glu Thr Tyr Asn Asp Glu Ser Arg Ile Lys Ala Thr Val Met 
            580                 585                 590         


Asp Val Lys Pro Val Asp Tyr Arg Glu Tyr Gly Arg Arg Leu Val Met 
        595                 600                 605             


Ser Ile Arg Arg Ser Ala Leu Met 
    610                 615     


<210>  3
<211>  1522
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Arg Asn Asp Lys Glu Pro Phe Phe Val Lys Phe Leu Lys Ser 
1               5                   10                  15      


Ser Asp Asn Ser Lys Cys Phe Phe Lys Ala Leu Glu Ser Ile Lys Glu 
            20                  25                  30          


Phe Gln Ser Glu Glu Tyr Leu Gln Ile Ile Thr Glu Glu Glu Ala Leu 
        35                  40                  45              


Lys Ile Lys Glu Asn Asp Arg Ser Leu Tyr Ile Cys Asp Pro Phe Ser 
    50                  55                  60                  


Gly Val Val Phe Asp His Leu Lys Lys Leu Gly Cys Arg Ile Val Gly 
65                  70                  75                  80  


Pro Gln Val Val Ile Phe Cys Met His His Gln Arg Cys Val Pro Arg 
                85                  90                  95      


Ala Glu His Pro Val Tyr Asn Met Val Met Ser Asp Val Thr Ile Ser 
            100                 105                 110         


Cys Thr Ser Leu Glu Lys Glu Lys Arg Glu Glu Val His Lys Tyr Val 
        115                 120                 125             


Gln Met Met Gly Gly Arg Val Tyr Arg Asp Leu Asn Val Ser Val Thr 
    130                 135                 140                 


His Leu Ile Ala Gly Glu Val Gly Ser Lys Lys Tyr Leu Val Ala Ala 
145                 150                 155                 160 


Asn Leu Lys Lys Pro Ile Leu Leu Pro Ser Trp Ile Lys Thr Leu Trp 
                165                 170                 175     


Glu Lys Ser Gln Glu Lys Lys Ile Thr Arg Tyr Thr Asp Ile Asn Met 
            180                 185                 190         


Glu Asp Phe Lys Cys Pro Ile Phe Leu Gly Cys Ile Ile Cys Val Thr 
        195                 200                 205             


Gly Leu Cys Gly Leu Asp Arg Lys Glu Val Gln Gln Leu Thr Val Lys 
    210                 215                 220                 


His Gly Gly Gln Tyr Met Gly Gln Leu Lys Met Asn Glu Cys Thr His 
225                 230                 235                 240 


Leu Ile Val Gln Glu Pro Lys Gly Gln Lys Tyr Glu Cys Ala Lys Arg 
                245                 250                 255     


Trp Asn Val His Cys Val Thr Thr Gln Trp Phe Phe Asp Ser Ile Glu 
            260                 265                 270         


Lys Gly Phe Cys Gln Asp Glu Ser Ile Tyr Lys Thr Glu Pro Arg Pro 
        275                 280                 285             


Glu Ala Lys Thr Met Pro Asn Ser Ser Thr Pro Thr Ser Gln Ile Asn 
    290                 295                 300                 


Thr Ile Asp Ser Arg Thr Leu Ser Asp Val Ser Asn Ile Ser Asn Ile 
305                 310                 315                 320 


Asn Ala Ser Cys Val Ser Glu Ser Ile Cys Asn Ser Leu Asn Ser Lys 
                325                 330                 335     


Leu Glu Pro Thr Leu Glu Asn Leu Glu Asn Leu Asp Val Ser Ala Phe 
            340                 345                 350         


Gln Ala Pro Glu Asp Leu Leu Asp Gly Cys Arg Ile Tyr Leu Cys Gly 
        355                 360                 365             


Phe Ser Gly Arg Lys Leu Asp Lys Leu Arg Arg Leu Ile Asn Ser Gly 
    370                 375                 380                 


Gly Gly Val Arg Phe Asn Gln Leu Asn Glu Asp Val Thr His Val Ile 
385                 390                 395                 400 


Val Gly Asp Tyr Asp Asp Glu Leu Lys Gln Phe Trp Asn Lys Ser Ala 
                405                 410                 415     


His Arg Pro His Val Val Gly Ala Lys Trp Leu Leu Glu Cys Phe Ser 
            420                 425                 430         


Lys Gly Tyr Met Leu Ser Glu Glu Pro Tyr Ile His Ala Asn Tyr Gln 
        435                 440                 445             


Pro Val Glu Ile Pro Val Ser His Lys Pro Glu Ser Lys Ala Ala Leu 
    450                 455                 460                 


Leu Lys Lys Lys Asn Ser Ser Phe Ser Lys Lys Asp Phe Ala Pro Ser 
465                 470                 475                 480 


Glu Lys His Glu Gln Ala Asp Glu Asp Leu Leu Ser Gln Tyr Glu Asn 
                485                 490                 495     


Gly Ser Ser Thr Val Val Glu Ala Lys Thr Ser Glu Ala Arg Pro Phe 
            500                 505                 510         


Asn Asp Ser Thr His Ala Glu Pro Leu Asn Asp Ser Thr His Ile Ser 
        515                 520                 525             


Leu Gln Glu Glu Asn Gln Ser Ser Val Ser His Cys Val Pro Asp Val 
    530                 535                 540                 


Ser Thr Ile Thr Glu Glu Gly Leu Phe Ser Gln Lys Ser Phe Leu Val 
545                 550                 555                 560 


Leu Gly Phe Ser Asn Glu Asn Glu Ser Asn Ile Ala Asn Ile Ile Lys 
                565                 570                 575     


Glu Asn Ala Gly Lys Ile Met Ser Leu Leu Ser Arg Thr Val Ala Asp 
            580                 585                 590         


Tyr Ala Val Val Pro Leu Leu Gly Cys Glu Val Glu Ala Thr Val Gly 
        595                 600                 605             


Glu Val Val Thr Asn Thr Trp Leu Val Thr Cys Ile Asp Tyr Gln Thr 
    610                 615                 620                 


Leu Phe Asp Pro Lys Ser Asn Pro Leu Phe Thr Pro Val Pro Val Met 
625                 630                 635                 640 


Thr Gly Met Thr Pro Leu Glu Asp Cys Val Ile Ser Phe Ser Gln Cys 
                645                 650                 655     


Ala Gly Ala Glu Lys Glu Ser Leu Thr Phe Leu Ala Asn Leu Leu Gly 
            660                 665                 670         


Ala Ser Val Gln Glu Tyr Phe Val Arg Lys Ser Asn Ala Lys Lys Gly 
        675                 680                 685             


Met Phe Ala Ser Thr His Leu Ile Leu Lys Glu Arg Gly Gly Ser Lys 
    690                 695                 700                 


Tyr Glu Ala Ala Lys Lys Trp Asn Leu Pro Ala Val Thr Ile Ala Trp 
705                 710                 715                 720 


Leu Leu Glu Thr Ala Arg Thr Gly Lys Arg Ala Asp Glu Ser His Phe 
                725                 730                 735     


Leu Ile Glu Asn Ser Thr Lys Glu Glu Arg Ser Leu Glu Thr Glu Ile 
            740                 745                 750         


Thr Asn Gly Ile Asn Leu Asn Ser Asp Thr Ala Glu His Pro Gly Thr 
        755                 760                 765             


Arg Leu Gln Thr His Arg Lys Thr Val Val Thr Pro Leu Asp Met Asn 
    770                 775                 780                 


Arg Phe Gln Ser Lys Ala Phe Arg Ala Val Val Ser Gln His Ala Arg 
785                 790                 795                 800 


Gln Val Ala Ala Ser Pro Ala Val Gly Gln Pro Leu Gln Lys Glu Pro 
                805                 810                 815     


Ser Leu His Leu Asp Thr Pro Ser Lys Phe Leu Ser Lys Asp Lys Leu 
            820                 825                 830         


Phe Lys Pro Ser Phe Asp Val Lys Asp Ala Leu Ala Ala Leu Glu Thr 
        835                 840                 845             


Pro Gly Arg Pro Ser Gln Gln Lys Arg Lys Pro Ser Thr Pro Leu Ser 
    850                 855                 860                 


Glu Val Ile Val Lys Asn Leu Gln Leu Ala Leu Ala Asn Ser Ser Arg 
865                 870                 875                 880 


Asn Ala Val Ala Leu Ser Ala Ser Pro Gln Leu Lys Glu Ala Gln Ser 
                885                 890                 895     


Glu Lys Glu Glu Ala Pro Lys Pro Leu His Lys Val Val Val Cys Val 
            900                 905                 910         


Ser Lys Lys Leu Ser Lys Lys Gln Ser Glu Leu Asn Gly Ile Ala Ala 
        915                 920                 925             


Ser Leu Gly Ala Asp Tyr Arg Trp Ser Phe Asp Glu Thr Val Thr His 
    930                 935                 940                 


Phe Ile Tyr Gln Gly Arg Pro Asn Asp Thr Asn Arg Glu Tyr Lys Ser 
945                 950                 955                 960 


Val Lys Glu Arg Gly Val His Ile Val Ser Glu His Trp Leu Leu Asp 
                965                 970                 975     


Cys Ala Gln Glu Cys Lys His Leu Pro Glu Ser Leu Tyr Pro His Thr 
            980                 985                 990         


Tyr Asn Pro Lys Met Ser Leu Asp  Ile Ser Ala Val Gln  Asp Gly Arg 
        995                 1000                 1005             


Leu Cys  Asn Ser Arg Leu Leu  Ser Ala Val Ser Ser  Thr Lys Asp 
    1010                 1015                 1020             


Asp Glu  Pro Asp Pro Leu Ile  Leu Glu Glu Asn Asp  Val Asp Asn 
    1025                 1030                 1035             


Met Ala  Thr Asn Asn Lys Glu  Ser Ala Pro Ser Asn  Gly Ser Gly 
    1040                 1045                 1050             


Lys Asn  Asp Ser Lys Gly Val  Leu Thr Gln Thr Leu  Glu Met Arg 
    1055                 1060                 1065             


Glu Asn  Phe Gln Lys Gln Leu  Gln Glu Ile Met Ser  Ala Thr Ser 
    1070                 1075                 1080             


Ile Val  Lys Pro Gln Gly Gln  Arg Thr Ser Leu Ser  Arg Ser Gly 
    1085                 1090                 1095             


Cys Asn  Ser Ala Ser Ser Thr  Pro Asp Ser Thr Arg  Ser Ala Arg 
    1100                 1105                 1110             


Ser Gly  Arg Ser Arg Val Leu  Glu Ala Leu Arg Gln  Ser Arg Gln 
    1115                 1120                 1125             


Thr Val  Pro Asp Val Asn Thr  Glu Pro Ser Gln Asn  Glu Gln Ile 
    1130                 1135                 1140             


Ile Trp  Asp Asp Pro Thr Ala  Arg Glu Glu Arg Ala  Arg Leu Ala 
    1145                 1150                 1155             


Ser Asn  Leu Gln Trp Pro Ser  Cys Pro Thr Gln Tyr  Ser Glu Leu 
    1160                 1165                 1170             


Gln Val  Asp Ile Gln Asn Leu  Glu Asp Ser Pro Phe  Gln Lys Pro 
    1175                 1180                 1185             


Leu His  Asp Ser Glu Ile Ala  Lys Gln Ala Val Cys  Asp Pro Gly 
    1190                 1195                 1200             


Asn Ile  Arg Val Thr Glu Ala  Pro Lys His Pro Ile  Ser Glu Glu 
    1205                 1210                 1215             


Leu Glu  Thr Pro Ile Lys Asp  Ser His Leu Ile Pro  Thr Pro Gln 
    1220                 1225                 1230             


Ala Pro  Ser Ile Ala Phe Pro  Leu Ala Asn Pro Pro  Val Ala Pro 
    1235                 1240                 1245             


His Pro  Arg Glu Lys Ile Ile  Thr Ile Glu Glu Thr  His Glu Glu 
    1250                 1255                 1260             


Leu Lys  Lys Gln Tyr Ile Phe  Gln Leu Ser Ser Leu  Asn Pro Gln 
    1265                 1270                 1275             


Glu Arg  Ile Asp Tyr Cys His  Leu Ile Glu Lys Leu  Gly Gly Leu 
    1280                 1285                 1290             


Val Ile  Glu Lys Gln Cys Phe  Asp Pro Thr Cys Thr  His Ile Val 
    1295                 1300                 1305             


Val Gly  His Pro Leu Arg Asn  Glu Lys Tyr Leu Ala  Ser Val Ala 
    1310                 1315                 1320             


Ala Gly  Lys Trp Val Leu His  Arg Ser Tyr Leu Glu  Ala Cys Arg 
    1325                 1330                 1335             


Thr Ala  Gly His Phe Val Gln  Glu Glu Asp Tyr Glu  Trp Gly Ser 
    1340                 1345                 1350             


Ser Ser  Ile Leu Asp Val Leu  Thr Gly Ile Asn Val  Gln Gln Arg 
    1355                 1360                 1365             


Arg Leu  Ala Leu Ala Ala Met  Arg Trp Arg Lys Lys  Ile Gln Gln 
    1370                 1375                 1380             


Arg Gln  Glu Ser Gly Ile Val  Glu Gly Ala Phe Ser  Gly Trp Lys 
    1385                 1390                 1395             


Val Ile  Leu His Val Asp Gln  Ser Arg Glu Ala Gly  Phe Lys Arg 
    1400                 1405                 1410             


Leu Leu  Gln Ser Gly Gly Ala  Lys Val Leu Pro Gly  His Ser Val 
    1415                 1420                 1425             


Pro Leu  Phe Lys Glu Ala Thr  His Leu Phe Ser Asp  Leu Asn Lys 
    1430                 1435                 1440             


Leu Lys  Pro Asp Asp Ser Gly  Val Asn Ile Ala Glu  Ala Ala Ala 
    1445                 1450                 1455             


Gln Asn  Val Tyr Cys Leu Arg  Thr Glu Tyr Ile Ala  Asp Tyr Leu 
    1460                 1465                 1470             


Met Gln  Glu Ser Pro Pro His  Val Glu Asn Tyr Cys  Leu Pro Glu 
    1475                 1480                 1485             


Ala Ile  Ser Phe Ile Gln Asn  Asn Lys Glu Leu Gly  Thr Gly Leu 
    1490                 1495                 1500             


Ser Gln  Lys Arg Lys Ala Pro  Thr Glu Lys Asn Lys  Ile Lys Arg 
    1505                 1510                 1515             


Pro Arg  Val His 
    1520         


<210>  4
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZnF1-3 binding domain

<400>  4

Phe Gln Cys Pro Ile Cys Gly Leu Val Ile Lys Arg Lys Ser Tyr Trp 
1               5                   10                  15      


Lys Arg His Met Val Ile His Thr Gly Leu Lys Ser His Gln Cys Pro 
            20                  25                  30          


Leu Cys Pro Phe Arg Cys Ala Arg Lys Asp Asn Leu Lys Ser His Met 
        35                  40                  45              


Lys Val His Gln His Gln Asp Arg Gly Glu Thr Phe Gln Cys Gln Leu 
    50                  55                  60                  


Cys Pro Phe Thr Ser Ser Arg His Phe Ser Leu Lys Leu His Met Arg 
65                  70                  75                  80  


Cys His 
        


<210>  5
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZnF4-9 binding domain

<400>  5

Phe Pro Cys Asp Val Cys Gly Lys Val Phe Gly Arg Gln Gln Thr Leu 
1               5                   10                  15      


Ser Arg His Leu Ser Leu His Thr Glu Glu Arg Lys Tyr Lys Cys His 
            20                  25                  30          


Leu Cys Pro Tyr Ala Ala Lys Cys Arg Ala Asn Leu Asn Gln His Leu 
        35                  40                  45              


Thr Val His Ser Val Lys Leu Val Ser Thr Asp Thr Glu Asp Ile Val 
    50                  55                  60                  


Ser Ala Val Thr Ser Glu Gly Ser Asp Gly Lys Lys His Pro Tyr Tyr 
65                  70                  75                  80  


Tyr Ser Cys His Val Cys Gly Phe Glu Thr Glu Leu Asn Val Gln Phe 
                85                  90                  95      


Val Ser His Met Ser Leu His Val Asp Lys Glu Gln Trp Met Phe Ser 
            100                 105                 110         


Ile Cys Cys Thr Ala Cys Asp Phe Val Thr Met Glu Glu Ala Glu Ile 
        115                 120                 125             


Lys Thr His Ile Gly Thr Lys His Thr Gly Glu Asp Arg Lys Thr Pro 
    130                 135                 140                 


Ser Glu Ser Asn Ser Pro Ser Ser Ser Ser Leu Ser Ala Leu Ser Asp 
145                 150                 155                 160 


Ser Ala Asn Ser Lys Asp Asp Ser Asp Gly Ser Gln Lys Asn Lys Gly 
                165                 170                 175     


Gly Asn Asn Leu Leu Val Ile Ser Val Met Pro Gly Ser Gln Pro Ser 
            180                 185                 190         


Leu Asn Ser Glu Glu Lys Pro Glu Lys Gly Phe Glu Cys Val Phe Cys 
        195                 200                 205             


Asn Phe Val Cys Lys Thr Lys Asn Met Phe Glu Arg His Leu Gln Ile 
    210                 215                 220                 


His Leu Ile Thr Arg Met Phe Glu Cys Asp Val Cys His Lys Phe Met 
225                 230                 235                 240 


Lys Thr Pro Glu Gln Leu Leu Glu His Lys Lys Cys His 
                245                 250             


<210>  6
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TOPBP1 binding domain

<400>  6

Asn His Thr Lys Leu Lys Asp Pro Ser Glu Tyr Val Ala Asn Ser Ala 
1               5                   10                  15      


Ser Ala Leu Phe Ser Gln Asp Ile Ser Val Lys Met Ala Ser Asp Phe 
            20                  25                  30          


Leu Met Lys Leu Ser Ala Ala Asn Gln Lys Glu Pro Met Asn Leu Asn 
        35                  40                  45              


Phe Lys Val Lys Glu Glu Pro Lys Glu Gly Glu Ser Leu Ser Thr Thr 
    50                  55                  60                  


Leu Pro Arg Ser Ser Tyr Val Phe Ser Pro Glu Ser Glu Val Ser Ala 
65                  70                  75                  80  


Pro Gly Val Ser Glu Asp Ala Leu Lys Pro Gln Glu Gly Lys Gly Ser 
                85                  90                  95      


Val Leu Arg Arg Asp Val Ser Val Lys Ala Ala Ser Glu Leu Leu Met 
            100                 105                 110         


Lys Leu Ser Ala Glu Ser Tyr Lys Glu Thr Gln Met Val Lys Ile Lys 
        115                 120                 125             


Glu Glu Pro Met Glu Val Asp Ile Gln Asp Ser His Val Ser Ile Ser 
    130                 135                 140                 


Pro Ser Arg Asn Val Gly Tyr Ser Thr Leu Ile Gly Arg Glu Lys Thr 
145                 150                 155                 160 


Glu Pro Leu Gln Lys Met Pro Glu Gly Arg Val Pro Pro Glu Arg Asn 
                165                 170                 175     


Leu Phe Ser Gln Asp Ile Ser Val Lys Met Ala Ser Glu Leu Leu Phe 
            180                 185                 190         


Gln Leu Ser Glu Lys Val Ser Lys Glu His Asn His Thr Lys Glu Asn 
        195                 200                 205             


Thr Ile Arg Thr Thr Thr Ser Pro Phe Phe Ser Glu Asp Thr Phe Arg 
    210                 215                 220                 


Gln Ser Pro Phe Thr Ser Asn Ser Lys Glu Leu Leu Pro Ser Asp Ser 
225                 230                 235                 240 


Val Leu His Gly Arg Ile Ser Ala Pro Glu Thr Glu Lys Ile Val Leu 
                245                 250                 255     


Glu Ala Gly Asn Gly Leu Pro Ser Trp Lys Phe Asn Asp Gln Leu 
            260                 265                 270     


<210>  7
<211>  7660
<212>  DNA
<213>  Homo sapiens

<400>  7
gacattagtg ttaggggctc ggagacacag agcgcggcca tagacaccgc cgcaccggca       60

ctcatttatt tatacctccc atcacacacg cgagcatagg acacacacac actcacacct      120

attagatccg tttccattga agaatattac gctcggggac aagccaggtg cacgaccaaa      180

aatttaaaaa aaaaaaaaaa aggaaaaaag aaaggaaaga aaagaagaaa acccctcttc      240

tggctccagg aaacaagctt caacccattg cacacaccgg agaaggggtt tccccctgcc      300

cgcccgcccg ccccccaact acctccccgc tcctgccagt gtctgcctct ctgcccccac      360

gggggtttat ttgatctcac attaaccaag gaggagaatg tgagaaaagg gggaaaatgc      420

ccaggaggaa gcaggagcag cccaagcgcc ttccctcaca tgttagtagg caggaagagg      480

cggagggaga gctcagtgaa ggagaacact ggtatggaaa ctcttcagag actccgtcag      540

aagcatccta tggggaagtc caggagaact ataagttgtc tctggaggac cggatccagg      600

agcagtccac gtccccggac acctccttgg gaagcacgac tcccagcagc cacacgttgg      660

agctggtggc actggacagt gaggtcctgc gagactcact gcagtgtcaa gatcaccttt      720

ccccgggagt gtcttctttg tgtgacgatg acccaggctc caacaagccc ctgagcagca      780

atttgaggcg gctgctggag gctggttccc tcaaactcga tgctgcagcc acggctaatg      840

gcagagtgga gtcccccgta aacgttggct cgaacctctc cttttccccg ccttcccacc      900

acgcccagca gctcagtgtt ctggccagga agttggccga gaagcaggaa cagaatgacc      960

aatacactcc aagtaaccgt tttatatgga atcaaggtaa gtggttgcca aactcaacca     1020

ccacctgcag cttgtctccg gattcagcca tcctaaaact gaaagctgca gccaatgccg     1080

ttctgcagga caaatctctc accaggactg aggagaccat gcgatttgag tccttttcct     1140

ccccttttag ctcccagtct gccagttcta ccttggccgc tttgtccaag aaggtcagtg     1200

aaagaagttt gactcctggt caggagcacc ctccaccggc cagctccttc ctttccctgg     1260

cttctatgac ctcctcagcg gcccttctga aggaggtggc cgcaagggct gcgggcagtc     1320

ttctggctga gaaatcatcg ctgctgcctg aggaccctct accgcccccg ccttcagaga     1380

agaaaccaga aaaagtcact ccgccacctc caccgccacc tccaccacct ccaccaccac     1440

caccacaatc cctggaatta ttattactcc cagttcctaa gggaagagtt tctaaaccct     1500

ccaattcagc ctcagaagag gaaagtggaa agcctttcca gtgtccaata tgtggtttgg     1560

ttattaaaag gaagagttac tggaagcggc acatggtgat tcacacaggt ttaaaaagtc     1620

atcagtgtcc gctctgtcca ttccggtgtg ctcgcaagga caatctcaaa tcccacatga     1680

aggttcatca gcaccaggat cggggagaga cctttcagtg ccagctgtgc ccttttactt     1740

cctcacgcca cttcagcctg aaactccaca tgcgttgcca tcagcacttc ctgaggacag     1800

aagccaaggt gaaggaggag atcccagacc cagatgtcaa gggatctccc cacctcagtg     1860

acagtgcctg cctggggcag caaagggaag gaggagggac agagctagtg gggaccatga     1920

tgacgtctaa cactccagag aggactagcc agggaggggc tggcgtctcg cctttgctgg     1980

tgaaggagga acccaaggaa gataacggcc tgcccacctc ctttactttg aatgctgccg     2040

acaggcccgc caaccacaca aagctgaaag acccctccga gtatgtggcc aacagtgcgt     2100

cagcattgtt cagccaggac atctctgtta agatggcgtc tgattttctc atgaagctgt     2160

cagctgcaaa tcagaaggag cccatgaatc ttaattttaa agtgaaagag gagcctaagg     2220

aaggggagtc cctaagcacg actttgcctc ggtccagcta tgtgttcagc ccggaatctg     2280

aagtgtcagc cccaggcgtc tctgaggacg cactaaagcc ccaggaaggg aagggaagtg     2340

tgctaaggcg ggatgtgtca gtcaaagcag cctctgaact tctcatgaaa ctctcagcgg     2400

aaagctacaa ggaaacacag atggtgaaga ttaaagagga acccatggag gttgacatcc     2460

aggactccca tgtctcgata tcacccagcc ggaatgttgg ctacagcact ttaatcgggc     2520

gagagaaaac cgaaccctta cagaagatgc cagagggcag agtaccccca gagagaaacc     2580

tcttcagtca ggatatctct gtgaaaatgg cttccgagct cctctttcaa ctgtcagaaa     2640

aagtgagcaa agagcacaat catacaaaag aaaacaccat ccggaccacg accagccctt     2700

tcttttcaga agacacattt agacaatcac cattcacctc caattcaaaa gaactgctgc     2760

ccagtgactc cgtgctgcac ggaagaatat cagctccaga aacagaaaag atagtcctag     2820

aggcaggaaa tggattacca tcctggaaat tcaatgacca gctttttccc tgtgacgtgt     2880

gtgggaaagt gtttggccga cagcagacat tgtcccgaca cctctcgctg cacacagagg     2940

aaagaaaata caaatgccac ttgtgcccct atgctgctaa gtgccgtgca aatctgaacc     3000

agcacttgac cgtccattcc gtgaagctgg tgagtacaga caccgaggac attgtcagcg     3060

ccgtcacctc tgaaggcagt gatgggaaga aacatcctta ttattacagt tgtcacgtgt     3120

gtggatttga gaccgagctc aatgtccagt ttgtcagcca catgtcactc cacgtggaca     3180

aggagcagtg gatgttttcg atctgctgca ctgcctgcga cttcgtcacc atggaggaag     3240

cagagataaa gactcacatt ggcaccaagc acacagggga agacaggaag acccccagcg     3300

aatcaaatag cccctcttca tcctccctct cagctctgag tgattcagcc aacagcaaag     3360

atgattcaga tggctcccag aaaaacaagg gcgggaacaa tctgctggtc atctctgtca     3420

tgcctgggag ccagccctca ctgaacagtg aggaaaagcc agagaaaggg ttcgaatgtg     3480

ttttttgcaa ctttgtctgc aagacgaaga acatgtttga gcgtcatctg cagatacacc     3540

tcatcacccg gatgtttgag tgtgatgtgt gccacaagtt catgaagacc cccgaacagc     3600

tgctggagca taagaaatgc cacactgtcc ccaccggtgg gctcaagtaa ggaaactcag     3660

gacagtggtg agtttcagac tcctctaggt gcccattctg catttattcc accaaccgcc     3720

ccgctgccat ggagtgccac ctcaagaccc actacaagat ggagtacaag tgccggatct     3780

gccagacggt gaaggccaac cagctggagc tggagacgca cacccgggag caccgcctgg     3840

gcaaccacta caagtgcgac cagtgcggct acctgtccaa gaccgccaac aagctcatcg     3900

agcacgtgcg cgtccacacc ggggagcggc ccttccactg tgaccagtgc agctacagct     3960

gcaagcgcaa ggacaatctc aacctgcaca agaagctgaa gcacgcccca cgccagacct     4020

tcagctgcga agagtgcctg ttcaagacca cacacccttt cgtcttcagc cgccacgtca     4080

agaagcacca gagtggggac tgccccgagg aggacaagaa gggcctgtgt ccagccccca     4140

aggaaccggc cggcccgggg gccccgctcc tggtggtcgg gagctcccgg aatctcctgt     4200

ctcccctgtc agttatgtct gcctcccagg ctctgcagac cgtggccctg tcggcagccc     4260

acggcagcag ctcagagccc aacctggcac tcaaggcttt ggccttcaac ggctcccctt     4320

tgcgctttga caagtaccgg aactcagatt ttgcccatct cattcccttg acaatgttat     4380

accccaagaa ccacttggat ctcacattcc accctccccg acctcagact gcgcctccca     4440

gcatcccctc acccaaacac tccttcctgg cctatctcgg actgagagaa agagcagaga     4500

ctgtctgagg gcagccatgt tctgtaccaa aaacagagag acaaaagaca aaaaaaaaaa     4560

aaaaaaccac aaaacttaaa cacaacccca gcaggtgtat gttgctgcaa aacctacaga     4620

ccccgatggg tctggaacat gtgtactgta tatctttagt aaggaataga aaattggctc     4680

tgtgtgtata cctattgcat tgacctgaaa gctgctttat ccaatcttca gagaggtgac     4740

ctactgcata cttctacctt cagaggcatg cctccccagc cacccactcc cactctcagc     4800

ccttctccgt acttttctct gaaaggaatc ttgtcttgtt aaaccctaaa gagagtgtcc     4860

ttaatagcaa tcagcacttg taagcttata tactggtgca tttggttttc tgttgggtga     4920

atgcggtgtg tgggcgtttg tggattctga aagagaaagc cgtgtgtcgt gtgccatgac     4980

atttctattg cacattcttt gtactggctt ctttaacagc gatgaacgtt cttttccctc     5040

ctgggttgtt catccacgac agtctctccc tgtgctcctt catcaccttt ccctctctct     5100

ttgatggcta cagagtggta gggcctggtg cttagtcgat gaaggaatgg tagccatcta     5160

cagtgctgct ggagatttcc gccagagcgc tggagacctt gcgctcagat cttctctggt     5220

gatgaagagg cgaggaatca agtgactgat ctggaagaaa tatctcgcag cactgcagct     5280

aacatcacag aacttaagtg tgttttgtgt gtgtgcccac acgtagacaa atgtgtacgg     5340

tgcacacaca cagtgcatca ttttttaagg gcagattata tatatatatg agatgtatta     5400

attcagtggt taccatttgt ttgcaggaaa aagaaatgta tgggtgaaaa aatttatggt     5460

tgataaatcc agccaaggag attaaaaggg gtttggataa attctgggta taaatgctca     5520

gactaaaaaa aagaaatggc agttttgcac agtgctatgg tcttgcacta gtttttgttt     5580

ctcatctgaa aaaaaaaaag taaaataaaa ggaagaaaat gtaccttttt tatggaatga     5640

gtagactgta tgtttgaaga tttagccaca acctctttga catataatga cgcaacaaaa     5700

aggtgctgtt tagtcctatg gttcagttta tgcccctgac aagtttccat tgtgttttgc     5760

cgatcttctg gctaatcgtg gtatcctcca tgttattagt aattctgtat tccattttgt     5820

taacgcctgg tagatgtaac ctgctaggag gctaacttta tacttattta aaagctctta     5880

ttttgtggtc attaaaatgg caatttatgt gcagcacttt attgcagcag gaagcaggtg     5940

tgggttggtt gtaaagctct ttgctaatct taaaaagtaa tgggtgattt aaaaagaaaa     6000

aaggaaaaaa atctttggct gaatatgttc attgcttgta tttttaaaac aacagaattt     6060

ccagtatgaa acaggctgaa agagcaggaa gaaatgttct ttgtataata atgggaagtt     6120

tggaatataa aagtttatat attatttatc tattggagaa ctggtgtaca ggaggaacat     6180

tttcttactg tgttgctgtt ttccatcatg tgttatccta agagttgggg ttttttaaaa     6240

tctgtttcac caggggaaaa taaaagcatc cctaatgttc ttcctctagt cagtttgctt     6300

tgctgaaagc tccctggaaa ttagtacagt tctacaggaa gccagaagac tgtactgtct     6360

gtccacacca tggtctcctc agtcccctcc acgccagccc ctcttcccca cacctagtag     6420

gtgtgctaca cctccctttg ccagtcatcc cgccatggat ggggagccta cttggtgccc     6480

tggcaaacct gtttacacta aggagatgcc cacagggagc gggaagctcc caaaccctca     6540

gtcattctcc agcagagacc tttgctcttg gccaggtttg aaacgatgtt caacctcgcc     6600

acgtcaatgt ctcagtaaaa gacactatag atagttatgg acaatacact ccaagaatac     6660

tgggcttatg ggtgggttgg ttttttgttt tgttttgttt tgttttcaag tcatgtcttt     6720

atccccatat aatggagaat gtgccacttg gctaataatg tgttttcaaa actacaagtt     6780

cagtgatgac aggaaagagg gctaaagtag tcccacagag gctggtagaa aaggcgaatc     6840

acacttaagc accagcaggt taaaaacctg aaagggtggc cctgacaatt cagactatag     6900

gttttacagc atgccacttg tgcaatagga ggtctagggt tgaaactttc aagaacgaga     6960

ggaggtgaag gaaggagacg tttactgctc aaatgccatg catttcactg cttgccactg     7020

aacttgtatt tgaatgactt agtaatgctt aatataattg ggcaactttt ttagcacttt     7080

ggaaagagtc atcaatcttt ctggtaaatt ataaaagttt tctgagtgag aaaaggtgtg     7140

tttggagttt gtttgacttt ttatattatt attgttatta ataaagaaaa aaatctacag     7200

catttttcag actccaccct agaaaatatg tacccctgaa tttggtttgc agtttgatac     7260

tcagggaagg atgtattcca tagatatcct ttccgtataa aacactaaca tctttgagaa     7320

attcacctac caactaactt caattgttgt cactatgcat tcttcaatga aaactagctt     7380

atttttccat atagtaatgc agttagggtt ctcagcactt tctttcttct atcctttttt     7440

taactcttca tattatgttc agatgatcat actgtcaagg tttgtgtaca ttactgaaaa     7500

tttgtattgt ataaagcttt ttgcattacg aggctgtaca gggtcatttt gacagtaact     7560

ggtatattcc tttgcatctt atgttgcatt gccaatttct agtgtatcca gtttgaaagt     7620

ataatatact ctaattaaaa aaaaaaaaag gttggctata                           7660


<210>  8
<211>  4847
<212>  DNA
<213>  Homo sapiens

<400>  8
ctcgggccaa taactgcgca gcgcgcggga cccgggtggg gaagctggag ctgttgcggg       60

gtccgcgggg aagtcttggc ggtggagcca tggtcggcca actgagcgag ggggccattg      120

cggccatcat gcagaagggg gatacaaaca taaagcccat cctccaagtc atcaacatcc      180

gtcccattac tacggggaat agtccgccgc gttatcgact gctcatgagt gatggattga      240

acactctatc ctctttcatg ttggcgacac agttgaaccc tctcgtggag gaagaacaat      300

tgtccagcaa ctgtgtatgc cagattcaca gatttattgt gaacactctg aaagacggaa      360

ggagagtagt tatcttgatg gaattagaag ttttgaagtc agctgaagca gttggagtga      420

agattggcaa tccagtgccc tataatgaag gactcgggca gccgcaagta gctcctccag      480

cgccagcagc cagcccagca gcaagcagca ggccccagcc gcagaatgga agctcgggaa      540

tgggttctac tgtttctaag gcttatggtg cttcaaagac atttggaaaa gctgcaggtc      600

ccagcctgtc acacacttct gggggaacac agtccaaagt ggtgcccatt gccagcctca      660

ctccttacca gtccaagtgg accatttgtg ctcgtgttac caacaaaagt cagatccgta      720

cctggagcaa ctcccgaggg gaagggaagc ttttctccct agaactggtt gacgaaagtg      780

gtgaaatccg agctacagct ttcaatgagc aagtggacaa gttctttcct cttattgaag      840

tgaacaaggt gtattatttc tcgaaaggca ccctgaagat tgctaacaag cagttcacag      900

ctgttaaaaa tgactacgag atgaccttca ataacgagac ttccgtcatg ccctgtgagg      960

acgaccatca tttacctacg gttcagtttg atttcacggg gattgatgac ctcgagaaca     1020

agtcgaaaga ctcacttgta gacatcatcg ggatctgcaa gagctatgaa gacgccacta     1080

aaatcacagt gaggtctaac aacagagaag ttgccaagag gaatatctac ttgatggaca     1140

catccgggaa ggtggtgact gctacactgt ggggggaaga tgctgataaa tttgatggtt     1200

ctagacagcc cgtgttggct atcaaaggag cccgagtctc tgatttcggt ggacggagcc     1260

tctccgtgct gtcttcaagc actatcattg cgaatcctga catcccagag gcctataagc     1320

ttcgtggatg gtttgacgca gaaggacaag ccttagatgg tgtttccatc tctgatctaa     1380

agagcggcgg agtcggaggg agtaacacca actggaaaac cttgtatgag gtcaaatccg     1440

agaacctggg ccaaggcgac aagccggact actttagttc tgtggccaca gtggtgtatc     1500

ttcgcaaaga gaactgcatg taccaagcct gcccgactca ggactgcaat aagaaagtga     1560

ttgatcaaca gaatggattg taccgctgtg agaagtgcga caccgaattt cccaatttca     1620

agtaccgcat gatcctgtca gtaaatattg cagattttca agagaatcag tgggtgactt     1680

gtttccagga gtctgctgaa gctatccttg gacaaaatgc tgcttatctt ggggaattaa     1740

aagacaagaa tgaacaggca tttgaagaag ttttccagaa tgccaacttc cgatctttca     1800

tattcagagt cagggtcaaa gtggagacct acaacgacga gtctcgaatt aaggccactg     1860

tgatggacgt gaagcccgtg gactacagag agtatggccg aaggctggtc atgagcatca     1920

ggagaagtgc attgatgtga gaggagcagt gccaatcggg cagaagtttg caaataggca     1980

gaatggaatc gatttcctcc cacctccgtg tgacgatccc atgttagcta cacagtgcag     2040

aggctcttga tggtggacta agcaatttcc cccctcgtgc gcatctcaga acccatcggt     2100

aggcaaagga aaatacgctc aggtggttgt ggtgtagact gtgtcaggcc tacggagtca     2160

gccagtggct agcgcaagac cagtcactcc ctctgccttc aggcttctgt caatttcatt     2220

atcatcaagc aggaattatg tcgtaagtca ctgaccctaa ctgcagacca tgaagtaaat     2280

tatgtaacta ggtttttgct tctccagtgg tgaccacccc cccccatccc cgctcacaac     2340

ttgggttctt ctcagcgggg cgagctgaga agcggtcatg agcacctggg gattttagta     2400

agtgtgtctt cctagaattc gaaggctctc tctttctaga ggtgctacat agttggtaat     2460

gcttggaatg gcaatagggt agaatgatta atcaaaggca tatcttctat atctgaagag     2520

tatccttcct tcagggttta atagactgag tcagatgggt ctgatattaa tcaaaattgt     2580

ctcttctgag gaccgctgat aagcattgac ttgccgtccc ctaaggaaat ccgagcggct     2640

acaaagcgtt tctttacttc tcacttcaat taatgctgcg cttcgcttgg tgagtgcgta     2700

ctttttctac ctgtacacat tcctgcattc atgtattttg ttttttttga ctaaagctat     2760

gttacatgga aaggattttg aagccttttg tttcccttgc tttgttttaa taaacagtat     2820

attctttggt tgtgaatcct actttctttg aatgcaaaga gttcctataa ctggaaagca     2880

attaattagc cttcataata aatgttcact tgggggggat gttaactcat tataaacccg     2940

aagattagtc caaggcatgg agatccttct tcctagtgtt tgcagccctg aaatgcatct     3000

ttcaaagcat gaaaacacta aaaacaaaaa gccattttgc ctgaggatgc tgatgatctg     3060

gcacttggga ttttattgat gtttacgcag cagtctaaca ccaaccacgc tttgaaatgt     3120

gtacagacag tgagctggta agaaaacagt aattatgcta gtgggccttt cagtcagcaa     3180

aagcatgctc gctctgtgtg ttcctaatca tattaattat ctatccggtg gctgcaacac     3240

accgcctgcc attggccgca catctcgccg tcgtaccccg gcagtgcggc ggtcactctg     3300

cagccagagg acctgctgtt catcactgca catgccgcct gcggaggctt ttggatatgg     3360

ggagtgatgg tgtcctgtct gtctcccccc tcggtgtctg ccgttgacat aggggccagc     3420

cagccctaga cgggatgact tccgttcctg aggacagaca cagagggact cctgctcagc     3480

ctcactaatt gtttagacac attccttcct acccttctct agtctcagga gatggtaact     3540

gggtcgcatt tcagtctctg actgaggcct cagccatttt tacggaagtt cttttctgtc     3600

tgaccttgct tataaagcat cgacgagaaa attacagtct tcaaccctct tctggattga     3660

caaattgtgg ctgggaagtg gcgatctagc tttcagccca gtaaccagtc tttcatgcct     3720

actactccca gcattccctc ctctccccac gtgtctgtcc acacagtgaa gaggcctgac     3780

cagccgtggt accaggacag gacgtgtcca gggaacgctg acacctgtcc tcgcgccttc     3840

tcagtggcca gcgtgatgaa accagcacgt ctccgtggat gtgattggga acccaggggc     3900

agtgccaggg ggagggctcc ctcgaggagg ctgtttctaa cagatttccc cactcaaaga     3960

tcagatcacc agcagaggag catcagaaac tggctccact gttgggcttt tcagagattt     4020

tggtccctgc gggttgccta aatagattct ggcccacagt ttacctcgaa aggctgttga     4080

tgttgttctg tttctcctct ttcacttaga gatcaatgtt gattttgcgt acaccatgac     4140

atcagcgtta ggcaattagg agaaaaaaat ctaatcattt cgcctttatt tcaagtggtt     4200

cttgaattcc ctccagtctc attgtgaaag gggcagggaa aaaaataaaa gggtaataat     4260

ctgatttctg tccatatttc cagtgtttta tgctttccat taaaaccttg ctaatctctc     4320

gcgtgctgtt ccttttttga actgcagggt caaaaatgtt cccctccccc acttctgttt     4380

cctgagtggg ctgtcttcaa aaagtataaa tactattgat cgtggtattt aatacactaa     4440

tgaaacccat ggttattgac tacataatta atatactgtc caaaagtgaa gtttggccgc     4500

ccagtatgta aaggtttata ttgactcatg tttctttggc aatatgccgc ccaaggtttt     4560

atttatagag gatgaaacag gttgtttggt ctccttttct tcttttcacc tgttagaagg     4620

ccactattcc cctagtaaac tgattgtttc cttgtctcaa agggaagatt ccccccactc     4680

cccggccacc ttttatgtgg tttgttaact cttagtctta tatccactcc gctggtagag     4740

ttctggcttt tataaacacc tttggaagtc atcggttcct caaaaagaga gcatagatgt     4800

ttaattttca cttattcaaa aaaactggta tttttgttat taagaca                   4847


<210>  9
<211>  1584
<212>  DNA
<213>  Homo sapiens

<400>  9
attcgcggga aggcgtttgt ggtgccagag aaaagtagcc agagcggcgc agtggcggcc       60

gcgttctgtg gttttccgct attcccccag acccgcacct tctcggcctc tttgcggaga      120

atcgtgacca agatgtggaa cagtggattc gaaagctatg gcagctcctc atacggggga      180

gccggcggct acacgcagtc cccggggggc tttggatcgc ccgcaccttc tcaagccgaa      240

aagaaatcaa gagcccgagc ccagcacatt gtgccctgta ctatatctca gctgctttct      300

gccactttgg ttgatgaagt gttcagaatt gggaatgttg agatttcaca ggtcactatt      360

gtggggatca tcagacatgc agagaaggct ccaaccaaca ttgtttacaa aatagatgac      420

atgacagctg cacccatgga cgttcgccag tgggttgaca cagatgacac cagcagtgaa      480

aacactgtgg ttcctccaga aacatatgtg aaagtggcag gccacctgag atcttttcag      540

aacaaaaaga gcctggtagc ctttaagatc atgcccctgg aggatatgaa tgagttcacc      600

acacatattc tggaagtgat caatgcacac atggtactaa gcaaagccaa cagccagccc      660

tcagcaggga gagcacctat cagcaatcca ggaatgagtg aagcagggaa ctttggtggg      720

aatagcttca tgccagcaaa tggcctcact gtggcccaaa accaggtgtt gaatttgatt      780

aaggcttgtc caagacctga agggttgaac tttcaggatc tcaagaacca gctgaaacac      840

atgtctgtat cctcaatcaa gcaagctgtg gattttctga gcaatgaggg gcacatctat      900

tctactgtgg atgatgacca ttttaaatcc acagatgcag aataactgga tctaactggg      960

tacctgagat attttacagc tggacctagt ttcacaatct gttgtctcca gctctgcata     1020

tgtctggcca gggggcttct aggaagtagg tttcatctat caaatgtctc ctctgacttc     1080

cttttgaaac ttactgctct tctgttttat tttgttttgt ttgaagctca gagggagatg     1140

ggcaattgac agggatgcaa tccagggtgg gatttcttga ggaagttaca aataagcttg     1200

ttacaacatc aagatagatg gaattggaag gatgctacca ggagagtact tacatagtgc     1260

tcaggagttt ctcttcttaa aatgtttact gctgaaagat gagcaggacc agggcgttat     1320

aggcagagcc ctagccgaga aacctgctgg cctctgcctg ttttcatttc ccactttggt     1380

tgtgtggcat tactttcaga attgcacttt cctgcttgtc atgacttttt gacacacttg     1440

ccatgacgtg tgtttctgtg aacatgaagt tctgcggtag tgcctccagg ggcagaggaa     1500

aagaagaagt gttactgcat tttgtacaaa ataaatacag tcatatgttt aataaaacag     1560

ttctattgta gtaacttgta aaaa                                            1584


<210>  10
<211>  2020
<212>  DNA
<213>  Homo sapiens

<400>  10
aagctactca gataagaggc tccaagagga catttttgga tgtgaaaaac aatgagaagg       60

aggacaacac acatttacaa tcgtcttaat tttgtactca gaaaaaggat gtgaagacaa      120

tgcacaggga atacaatagt ttcagatctg tgtacagttt ccttttgctt catctcctgc      180

aacaatgtaa tgaagacacc atgatatcat taacatttca cacaaaagga aaatgaggct      240

gaaatggtgt gggcaaggcc caggaatctg gagcatccct aaccaagcag gagagcacct      300

gggatagaga aagtgctcaa gaatgttcac ttactgatta ctacaatcaa aaaaagatac      360

gacactaatt taccacattc ttcttactta ttttatgaga tactattctt ccaaggtgga      420

gaaagtggag aaagtagagt gacgcagcta agggagtaaa tcgaccctca gccaacaagt      480

ggcaaaagcc tgaagaaagt gatcaagatc actgatgacc ccgctgccca tctccaaggg      540

ggcgggtatc acaaccccga cgccacacca cgtatcattc cgcaaaactc ccgcgcctcc      600

cacgcagaac tggcaagagg gaaggcgaga cagcagtgaa cagctggtac gcagcaccca      660

cagcaccgcg gcagcagcta gtgccgactc ccgcctagct cttttgactc tgttcgcggg      720

aagaatgggg aaacagtaag gttgcggcgc ctcccgcgag acgaggtacc tgaggctggc      780

cccgcagtcc cccgccgcac cagcaccgga gcttcacacc ccacttccgg ggtcaagtca      840

ccgccgggaa tcctgtgatc gcagaaaggt agtctcaggt tccgccccta tccaagtccc      900

gcctccactg cctctcgccc tgtatctgtc aacttccggg acgccgcgcg tcactaagca      960

gccaatctcc acttccggac tcatccagcc ccttctccac ccctttcaga gacagcgcga     1020

ttgcgattta ggtttccgcg catttaattg gcgaagctgg agcgctagtc ttcgctgatt     1080

ggtgccgaga aatctgcccc atagacaccc gcggggcgca cagtttcagt cgtccgtggg     1140

tttcccgcca gccgcagtct tggaccataa tcatggtgga catgatggac ttgcccaggt     1200

cgcgcatcaa cgccggcatg ctagctcaat tcatcgacaa gcctgtctgc ttcgtaggga     1260

ggctggaaaa gattcatccc accggaaaaa tgtttattct ttcagatgga gaaggaaaaa     1320

atggaaccat cgagttgatg gaaccccttg atgaagaaat ctctggaatt gtggaagtgg     1380

ttggaagagt aaccgccaag gccaccatct tgtgtacatc ttatgtccag tttaaagaag     1440

atagccatcc ttttgatctt ggactttaca atgaagctgt gaaaattatc catgacttcc     1500

ctcagtttta tcctttaggg attgtgcaac atgattgatc ttgatggatt ttcatacgat     1560

tgtaaatgag ctatattaaa gtctattaaa ggaagccctt cttgtttgag ggagagattt     1620

ctgtgctttc tcatatttaa tttgctgttt ttaagatatt ccaacctaga gtttttgatg     1680

gaactgatat attgacagtt ctcaccgaag tccttttata aagaattgct actccaatat     1740

atggtcagat tagatgcaag aataaagcag ttgtccgagt ctaagtttct attttattaa     1800

taaaaactaa aatggtacgt actatcggtc atttcatttt cattctttta atcatgtatt     1860

caagcacaaa cttgaaattt catagccata aggtcaagat ttagacctac caaataaaac     1920

cttgggccag ctgtgttaag gatttgctca ccttttccca aactatacct tgataattat     1980

ttccttgata ccctacttac aaaatgaagt agatgacatt                           2020


<210>  11
<211>  5761
<212>  DNA
<213>  Homo sapiens

<400>  11
agtcggttcc cgttctgggc aatttccggg ttctccagcg tttgctttgg ggtaggggcg       60

gcgccgagtc gggggagggg gctgtgcgcc gggctggcgc ccgaccccag ccaccgccct      120

gcggccagcg cgtcccccga ctcgccgccc ggagaccccg aggctccaac gagttcagaa      180

atgtccagaa atgacaaaga accgtttttt gtgaagtttt taaagtcttc agacaattcc      240

aaatgttttt ttaaagctct cgagtccata aaagaattcc aatcagaaga atatcttcag      300

attattacag aagaagaggc attgaagata aaggagaatg atagatcact ttatatctgt      360

gaccctttta gtggcgttgt ctttgatcac ctcaaaaagc ttggctgcag aattgttggt      420

cctcaagtag tcatattttg tatgcaccac cagcgatgtg tcccaagagc cgaacatcca      480

gtttataata tggttatgtc tgatgtaacc atatcttgta caagtctgga aaaagaaaaa      540

agggaagaag ttcataaata tgtacaaatg atgggcggac gagtatacag agaccttaat      600

gtatcagtaa ctcaccttat tgcaggagaa gttggtagca aaaaatattt agttgctgca      660

aacctgaaga aacctatttt gcttccctct tggataaaaa cactttggga gaagtcacaa      720

gagaaaaaaa taactagata tactgatata aacatggaag atttcaagtg tcctattttt      780

cttggttgca taatctgtgt gactggctta tgtggcttag acaggaaaga agttcagcaa      840

ctcacagtta agcatggagg tcaatacatg ggacaattga aaatgaatga atgtacacac      900

ctcattgtgc aagaaccaaa aggtcagaag tatgagtgtg ccaagagatg gaatgtacac      960

tgtgtgacca cacagtggtt ttttgacagt attgagaaag gtttttgtca ggatgaatcc     1020

atatacaaga cagaacctag accagaagca aagactatgc ccaattcttc aactcctacc     1080

agccagatca acacaattga tagtcgtact ctttcagatg tcagcaatat ttccaacata     1140

aatgcaagtt gcgtaagtga atcaatatgt aattcactta acagcaaact ggagcctaca     1200

cttgaaaatc tagaaaatct ggatgtcagt gcatttcaag cacctgaaga tttattagat     1260

ggttgtcgga tatatctttg cggttttagt ggcagaaagc tagataaact gagaagactt     1320

attaacagtg gaggtggagt tcgttttaac cagctaaatg aagatgtaac tcatgttatt     1380

gtgggagatt atgatgatga attgaagcag ttttggaata aatcagccca caggcctcat     1440

gtagtgggag caaagtggtt gctagagtgt ttcagtaaag gttatatgct ttctgaagaa     1500

ccatatatcc atgctaatta ccagccagtg gaaattccag tttcacataa gcctgaaagt     1560

aaagcagctc ttttaaaaaa gaagaacagc agcttctcta agaaagactt tgctcctagt     1620

gaaaagcatg agcaagctga tgaagatctg ctctctcaat atgaaaatgg tagctccaca     1680

gtagttgagg ctaagacgtc tgaagccagg ccctttaatg attctactca tgctgagccc     1740

ttgaatgatt ctactcacat ttctttgcaa gaagaaaacc agtcttctgt cagtcattgt     1800

gtccctgatg tttctacaat tactgaagaa ggcttattta gccaaaagag tttccttgtt     1860

ttgggtttta gtaatgaaaa tgaatctaac atcgcaaaca tcataaaaga aaatgctggg     1920

aaaatcatgt cccttctgag cagaactgtt gcggattatg ctgtggttcc tctgctgggg     1980

tgtgaagtgg aagccactgt gggagaagtt gttacaaata catggctggt tacttgcata     2040

gactatcaga ctttgtttga tccaaagtcg aatcctctct tcacaccagt tccagtaatg     2100

acaggaatga ctcctttaga ggattgtgtt atttcattta gccagtgtgc tggagcagaa     2160

aaagagtctt taacattcct agcaaacctc cttggagcaa gtgttcaaga atactttgtt     2220

cgcaaatcca atgcaaagaa aggcatgttt gccagtactc atcttatact gaaagaacgt     2280

ggtggctcta aatatgaagc tgcaaagaag tggaatttac ctgccgttac tatagcttgg     2340

ctgttggaga ctgctagaac gggaaagaga gcagacgaaa gccattttct gattgaaaat     2400

tcaactaaag aagaacgaag tttggaaaca gaaataacaa atggaatcaa tctaaattca     2460

gatactgcag agcatcctgg cacacgcctg caaactcaca gaaaaaccgt cgttacacct     2520

ttagatatga accgctttca gagtaaagct ttccgtgctg tggtctcaca acatgccaga     2580

caggtcgcag cctccccagc agtaggacaa ccacttcaga aggagccctc gttacacctg     2640

gatacaccat caaaattcct gtccaaggac aaactcttca agccttcctt tgatgtgaag     2700

gatgcacttg cagccttgga aactccagga cgtcccagcc aacagaaaag gaaaccgagt     2760

acgccactct cagaagttat tgtcaaaaac ttgcaacttg ctttggcaaa tagctctcga     2820

aatgctgtcg ctctttctgc cagccctcaa ctgaaagagg cccagtcaga gaaggaagaa     2880

gccccaaagc cacttcacaa agtagtggta tgtgttagta aaaaactcag taagaagcag     2940

agtgaactaa atgggatcgc agcctctcta ggagcagatt acaggtggag ttttgatgaa     3000

acagtgactc atttcatcta tcaagggcgg ccaaatgaca ctaatcggga gtataaatct     3060

gtaaaagaaa gaggagtaca cattgtttcc gagcactggc ttttagattg tgcccaagag     3120

tgtaaacatc ttcctgaatc tctttatcca catacttata atcccaaaat gagcttggat     3180

atcagcgcag tgcaagatgg ccggctctgt aatagtcgac tactctcagc tgtgtcttca     3240

acaaaggatg atgagccaga tcctttgatt ttagaagaaa atgatgtaga caatatggcc     3300

accaataata aagagtcagc accatcaaat ggaagtggaa agaatgactc taaaggagtt     3360

ctgacacaga ccttagagat gagagagaac tttcagaagc agttacagga gataatgtct     3420

gcaacatcaa tagtgaaacc ccaagggcag aggacttccc tttcaagaag tggttgtaac     3480

agcgcatctt caacccctga cagcactcgc tctgctcgca gtggacgaag tagagtccta     3540

gaggcactga ggcagtctcg tcagacagta cctgatgtca acacagagcc ttcccaaaat     3600

gaacagatca tttgggatga ccctacagca agggaggaga gagcaaggct tgccagcaat     3660

ttgcagtggc ctagttgtcc cacacaatac tctgagcttc aggttgacat tcaaaacttg     3720

gaggattctc cttttcaaaa gcctttacat gattcagaaa ttgctaaaca ggctgtctgt     3780

gatcctggaa acatacgtgt gactgaagct cccaaacacc caatctctga agaactggaa     3840

actcccataa aagacagcca cctgatccct acgcctcaag cccccagtat tgcctttcca     3900

ctcgccaacc cccctgtggc tccgcaccct agagaaaaga ttataacgat agaggagact     3960

catgaagaat taaaaaaaca gtacatattt cagttatcat ctctgaatcc tcaagaacgt     4020

attgactatt gtcatctgat tgagaaacta ggtggattgg tgatagaaaa gcagtgcttt     4080

gatcccacct gtacacacat tgttgtggga catccacttc gaaacgagaa gtatttagcc     4140

tcagtggcag ctgggaagtg ggtgcttcat cgctcctacc ttgaagcctg caggactgct     4200

ggacacttcg tgcaggaaga agactatgaa tggggaagta gttccatact tgatgttctg     4260

actggaatca atgtacagca acgaagacta gcacttgcag caatgagatg gagaaaaaaa     4320

atccagcaaa gacaagaatc tggcattgtt gagggagcat ttagtgggtg gaaggttatt     4380

ttacatgtgg atcagtctcg agaagcaggc ttcaaacgcc ttcttcagtc aggaggagca     4440

aaggtgctac ctggtcattc tgtaccttta tttaaagagg ccacacatct tttttctgac     4500

ttgaataaac tgaaaccaga tgactcagga gttaatatag cagaagctgc tgcccagaac     4560

gtgtactgct tgagaacaga atacattgct gattatctca tgcaggaatc acctcctcat     4620

gtagaaaatt actgtctacc agaagctatt tcatttattc agaataataa ggaacttggg     4680

actggattat cacaaaagag gaaagctcct acagaaaaaa ataaaatcaa acgacctaga     4740

gtacactaat cgcatctacc ctttagttac caaacattaa atgtttttaa aaattgaaag     4800

cctgaatgtg actgtgatag atttgggtag taatttaaag atgagtacct gaagaattct     4860

gcttcagagt ataatgatga cccttcttga gttttgaaca cctgaaattg taatcactga     4920

aatattaact gtttcttaat aaaaagttac ctgaaataac aacaaaatac aactcctcag     4980

ctagcttgct gttaaaccac attgaagtct gttaaaagat atttattttt cttgtaaata     5040

tctgaagctg tagcttagtg gaaattttag caaggtaatg gattttgctt taaaatgtct     5100

gccttacaaa ttcataacaa caagatttgt cagtcagcat ttattcatgt tttccctgat     5160

ttttatcttc tcaccatttt acctctttta acaggagcct gagcacaagg tttaatgagg     5220

aagctggggc tataaatatg tgtgtatata tgtatatgta tgtttgtaca aatctccatg     5280

atgtttgcca agtttgaatg cgcaaaactt ggaaaatgtg acaataaaga ataaaagtag     5340

taactcaaat tagtattaag atgtgtttac atagataaat tttttaaaag agcaccctgg     5400

catctgttct tctgttgaag caacaaaaca tttatgtaac gtaaaaaatg aattgcaggg     5460

gcctgggtgc ggtggctcgt gcctgtaatc ccagcacttt gggaggctga ggcaggcgga     5520

tcgtctgagg tcgggagttt gagaccagcc tgaccaacat ggagaaacct catctgtact     5580

aaaaatacaa aaaattagcc cagtgtggtg gcacatgcct gtaatcccag ctactcagga     5640

ggctgaggca ggagaatcgc ttgaacccgg gaggcggagg ttgcggtgag ctgagatcgc     5700

gccattgcac tccagcctgg gcaacaagag cgaaactcca tctcaaaaaa aaaaaaaaaa     5760

a                                                                     5761


<210>  12
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siZNF827 siRNA 1

<400>  12
gggcagucuu cuggcugaga aauca                                             25


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ZNF827 siRNA 2

<400>  13
ugauuucuca gccagaagac ugccc                                             25


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZNF827 RRK domain

<400>  14

Met Pro Arg Arg Lys Gln Pro Gln Glu Lys 
1               5                   10  


<210>  15
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  16
<211>  3090
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZnF1-3 domain mutant DNA

<400>  16
gcgatcgcca tgcccaggag gaagcaggag cagcccaagc gccttccctc acatgttagt       60

aggcaggaag aggcggaggg agagctcagt gaaggagaac actggtatgg aaactcttca      120

gagactccgt cagaagcatc ctatggggaa gtccaggaga actataagtt gtctctggag      180

gaccggatcc aggagcagtc cacgtccccg gacacctcct tgggaagcac gactcccagc      240

agccacacgt tggagctggt ggcactggac agtgaggtcc tgcgagactc actgcagtgt      300

caagatcacc tttccccggg agtgtcttct ttgtgtgacg atgacccagg ctccaacaag      360

cccctgagca gcaatttgag gcggctgctg gaggctggtt ccctcaaact cgatgctgca      420

gccacggcta atggcagagt ggagtccccc gtaaacgttg gctcgaacct ctccttttcc      480

ccgccttccc accacgccca gcagctcagt gttctggcca ggaagttggc cgagaagcag      540

gaacagaatg accaatacac tccaagtaac cgttttatat ggaatcaagg taagtggttg      600

ccaaactcaa ccaccacctg cagcttgtct ccggattcag ccatcctaaa actgaaagct      660

gcagccaatg ccgttctgca ggacaaatct ctcaccagga ctgaggagac catgcgattt      720

gagtcctttt cctccccttt tagctcccag tctgccagtt ctaccttggc cgctttgtcc      780

aagaaggtca gtgaaagaag tttgactcct ggtcaggagc accctccacc ggccagctcc      840

ttcctttccc tggcttctat gacctcctca gcggcccttc tgaaggaggt ggccgcaagg      900

gctgcgggca gtcttctggc tgagaaatca tcgctgctgc ctgaggaccc tctaccgccc      960

ccgccttcag agaagaaacc agaaaaagtc actccgccac ctccaccgcc acctccacca     1020

cctccaccac caccaccaca atccctggaa ttattattac tcccagttcc taagggaaga     1080

gtttctaaac cctccaattc agcctcagaa gaggaaagtg gaaagcctca gcacttcctg     1140

aggacagaag ccaaggtgaa ggaggagatc ccagacccag atgtcaaggg atctccccac     1200

ctcagtgaca gtgcctgcct ggggcagcaa agggaaggag gagggacaga gctagtgggg     1260

accatgatga cgtctaacac tccagagagg actagccagg gaggggctgg cgtctcgcct     1320

ttgctggtga aggaggaacc caaggaagat aacggcctgc ccacctcctt tactttgaat     1380

gctgccgaca ggcccgccaa ccacacaaag ctgaaagacc cctccgagta tgtggccaac     1440

agtgcgtcag cattgttcag ccaggacatc tctgttaaga tggcgtctga ttttctcatg     1500

aagctgtcag ctgcaaatca gaaggagccc atgaatctta attttaaagt gaaagaggag     1560

cctaaggaag gggagtccct aagcacgact ttgcctcggt ccagctatgt gttcagcccg     1620

gaatctgaag tgtcagcccc aggcgtctct gaggacgcac taaagcccca ggaagggaag     1680

ggaagtgtgc taaggcggga tgtgtcagtc aaagcagcct ctgaacttct catgaaactc     1740

tcagcggaaa gctacaagga aacacagatg gtgaagatta aagaggaacc catggaggtt     1800

gacatccagg actcccatgt ctcgatatca cccagccgga atgttggcta cagcacttta     1860

atcgggcgag agaaaaccga acccttacag aagatgccag agggcagagt acccccagag     1920

agaaacctct tcagtcagga tatctctgtg aaaatggctt ccgagctcct ctttcaactg     1980

tcagaaaaag tgagcaaaga gcacaatcat acaaaagaaa acaccatccg gaccacgacc     2040

agccctttct tttcagaaga cacatttaga caatcaccat tcacctccaa ttcaaaagaa     2100

ctgctgccca gtgactccgt gctgcacgga agaatatcag ctccagaaac agaaaagata     2160

gtcctagagg caggaaatgg attaccatcc tggaaattca atgaccagct ttttccctgt     2220

gacgtgtgtg ggaaagtgtt tggccgacag cagacattgt cccgacacct ctcgctgcac     2280

acagaggaaa gaaaatacaa atgccacttg tgcccctatg ctgctaagtg ccgtgcaaat     2340

ctgaaccagc acttgaccgt ccattccgtg aagctggtga gtacagacac cgaggacatt     2400

gtcagcgccg tcacctctga aggcagtgat gggaagaaac atccttatta ttacagttgt     2460

cacgtgtgtg gatttgagac cgagctcaat gtccagtttg tcagccacat gtcactccac     2520

gtggacaagg agcagtggat gttttcgatc tgctgcactg cctgcgactt cgtcaccatg     2580

gaggaagcag agataaagac tcacattggc accaagcaca caggggaaga caggaagacc     2640

cccagcgaat caaatagccc ctcttcatcc tccctctcag ctctgagtga ttcagccaac     2700

agcaaagatg attcagatgg ctcccagaaa aacaagggcg ggaacaatct gctggtcatc     2760

tctgtcatgc ctgggagcca gccctcactg aacagtgagg aaaagccaga gaaagggttc     2820

gaatgtgttt tttgcaactt tgtctgcaag acgaagaaca tgtttgagcg tcatctgcag     2880

atacacctca tcacccggat gtttgagtgt gatgtgtgcc acaagttcat gaagaccccc     2940

gaacagctgc tggagcataa gaaatgccac actgtcccca ccggtgggct caagacgcgt     3000

acgcggccgc tcgagcagaa actcatctca gaagaggatc tggcagcaaa tgatatcctg     3060

gattacaagg atgacgacga taaggtttaa                                      3090


<210>  17
<211>  2709
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZnF4-9 domain mutant DNA

<400>  17
gcgatcgcca tgcccaggag gaagcaggag cagcccaagc gccttccctc acatgttagt       60

aggcaggaag aggcggaggg agagctcagt gaaggagaac actggtatgg aaactcttca      120

gagactccgt cagaagcatc ctatggggaa gtccaggaga actataagtt gtctctggag      180

gaccggatcc aggagcagtc cacgtccccg gacacctcct tgggaagcac gactcccagc      240

agccacacgt tggagctggt ggcactggac agtgaggtcc tgcgagactc actgcagtgt      300

caagatcacc tttccccggg agtgtcttct ttgtgtgacg atgacccagg ctccaacaag      360

cccctgagca gcaatttgag gcggctgctg gaggctggtt ccctcaaact cgatgctgca      420

gccacggcta atggcagagt ggagtccccc gtaaacgttg gctcgaacct ctccttttcc      480

ccgccttccc accacgccca gcagctcagt gttctggcca ggaagttggc cgagaagcag      540

gaacagaatg accaatacac tccaagtaac cgttttatat ggaatcaagg taagtggttg      600

ccaaactcaa ccaccacctg cagcttgtct ccggattcag ccatcctaaa actgaaagct      660

gcagccaatg ccgttctgca ggacaaatct ctcaccagga ctgaggagac catgcgattt      720

gagtcctttt cctccccttt tagctcccag tctgccagtt ctaccttggc cgctttgtcc      780

aagaaggtca gtgaaagaag tttgactcct ggtcaggagc accctccacc ggccagctcc      840

ttcctttccc tggcttctat gacctcctca gcggcccttc tgaaggaggt ggccgcaagg      900

gctgcgggca gtcttctggc tgagaaatca tcgctgctgc ctgaggaccc tctaccgccc      960

ccgccttcag agaagaaacc agaaaaagtc actccgccac ctccaccgcc acctccacca     1020

cctccaccac caccaccaca atccctggaa ttattattac tcccagttcc taagggaaga     1080

gtttctaaac cctccaattc agcctcagaa gaggaaagtg gaaagccttt ccagtgtcca     1140

atatgtggtt tggttattaa aaggaagagt tactggaagc ggcacatggt gattcacaca     1200

ggtttaaaaa gtcatcagtg tccgctctgt ccattccggt gtgctcgcaa ggacaatctc     1260

aaatcccaca tgaaggttca tcagcaccag gatcggggag agacctttca gtgccagctg     1320

tgccctttta cttcctcacg ccacttcagc ctgaaactcc acatgcgttg ccatcagcac     1380

ttcctgagga cagaagccaa ggtgaaggag gagatcccag acccagatgt caagggatct     1440

ccccacctca gtgacagtgc ctgcctgggg cagcaaaggg aaggaggagg gacagagcta     1500

gtggggacca tgatgacgtc taacactcca gagaggacta gccagggagg ggctggcgtc     1560

tcgcctttgc tggtgaagga ggaacccaag gaagataacg gcctgcccac ctcctttact     1620

ttgaatgctg ccgacaggcc cgccaaccac acaaagctga aagacccctc cgagtatgtg     1680

gccaacagtg cgtcagcatt gttcagccag gacatctctg ttaagatggc gtctgatttt     1740

ctcatgaagc tgtcagctgc aaatcagaag gagcccatga atcttaattt taaagtgaaa     1800

gaggagccta aggaagggga gtccctaagc acgactttgc ctcggtccag ctatgtgttc     1860

agcccggaat ctgaagtgtc agccccaggc gtctctgagg acgcactaaa gccccaggaa     1920

gggaagggaa gtgtgctaag gcgggatgtg tcagtcaaag cagcctctga acttctcatg     1980

aaactctcag cggaaagcta caaggaaaca cagatggtga agattaaaga ggaacccatg     2040

gaggttgaca tccaggactc ccatgtctcg atatcaccca gccggaatgt tggctacagc     2100

actttaatcg ggcgagagaa aaccgaaccc ttacagaaga tgccagaggg cagagtaccc     2160

ccagagagaa acctcttcag tcaggatatc tctgtgaaaa tggcttccga gctcctcttt     2220

caactgtcag aaaaagtgag caaagagcac aatcatacaa aagaaaacac catccggacc     2280

acgaccagcc ctttcttttc agaagacaca tttagacaat caccattcac ctccaattca     2340

aaagaactgc tgcccagtga ctccgtgctg cacggaagaa tatcagctcc agaaacagaa     2400

aagatagtcc tagaggcagg aaatggatta ccatcctgga aattcaatga ccagctttca     2460

aatagctctt catcctccct ctcagctctg agtgattcag ccaacagcaa agatgattca     2520

gatggctccc agaaaaacaa gggcgggaac aatctgctgg tcatctctgt catgcctggg     2580

agccagccca ctgtccccac cggtgggctc aagacgcgta cgcggccgct cgagcagaaa     2640

ctcatctcag aagaggatct ggcagcaaat gatatcctgg attacaagga tgacgacgat     2700

aaggtttaa                                                             2709


<210>  18
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZnF1-9 domain mutant DNA

<400>  18
gcgatcgcca tgcccaggag gaagcaggag cagcccaagc gccttccctc acatgttagt       60

aggcaggaag aggcggaggg agagctcagt gaaggagaac actggtatgg aaactcttca      120

gagactccgt cagaagcatc ctatggggaa gtccaggaga actataagtt gtctctggag      180

gaccggatcc aggagcagtc cacgtccccg gacacctcct tgggaagcac gactcccagc      240

agccacacgt tggagctggt ggcactggac agtgaggtcc tgcgagactc actgcagtgt      300

caagatcacc tttccccggg agtgtcttct ttgtgtgacg atgacccagg ctccaacaag      360

cccctgagca gcaatttgag gcggctgctg gaggctggtt ccctcaaact cgatgctgca      420

gccacggcta atggcagagt ggagtccccc gtaaacgttg gctcgaacct ctccttttcc      480

ccgccttccc accacgccca gcagctcagt gttctggcca ggaagttggc cgagaagcag      540

gaacagaatg accaatacac tccaagtaac cgttttatat ggaatcaagg taagtggttg      600

ccaaactcaa ccaccacctg cagcttgtct ccggattcag ccatcctaaa actgaaagct      660

gcagccaatg ccgttctgca ggacaaatct ctcaccagga ctgaggagac catgcgattt      720

gagtcctttt cctccccttt tagctcccag tctgccagtt ctaccttggc cgctttgtcc      780

aagaaggtca gtgaaagaag tttgactcct ggtcaggagc accctccacc ggccagctcc      840

ttcctttccc tggcttctat gacctcctca gcggcccttc tgaaggaggt ggccgcaagg      900

gctgcgggca gtcttctggc tgagaaatca tcgctgctgc ctgaggaccc tctaccgccc      960

ccgccttcag agaagaaacc agaaaaagtc actccgccac ctccaccgcc acctccacca     1020

cctccaccac caccaccaca atccctggaa ttattattac tcccagttcc taagggaaga     1080

gtttctaaac cctccaattc agcctcagaa gaggaaagtg gaaagcctca gcacttcctg     1140

aggacagaag ccaaggtgaa ggaggagatc ccagacccag atgtcaaggg atctccccac     1200

ctcagtgaca gtgcctgcct ggggcagcaa agggaaggag gagggacaga gctagtgggg     1260

accatgatga cgtctaacac tccagagagg actagccagg gaggggctgg cgtctcgcct     1320

ttgctggtga aggaggaacc caaggaagat aacggcctgc ccacctcctt tactttgaat     1380

gctgccgaca ggcccgccac gcgtacgcgg ccgctcgagc agaaactcat ctcagaagag     1440

gatctggcag caaatgatat cctggattac aaggatgacg acgataaggt ttaa           1494


<210>  19
<211>  3336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZnF sumo domain mutant DNA

<400>  19
gcgatcgcca tgcccaggag gaagcaggag cagcccaagc gccttccctc acatgttagt       60

aggcaggaag aggcggaggg agagctcagt gaaggagaac actggtatgg aaactcttca      120

gagactccgt cagaagcatc ctatggggaa gtccaggaga actataagtt gtctctggag      180

gaccggatcc aggagcagtc cacgtccccg gacacctcct tgggaagcac gactcccagc      240

agccacacgt tggagctggt ggcactggac agtgaggtcc tgcgagactc actgcagtgt      300

caagatcacc tttccccggg agtgtcttct ttgtgtgacg atgacccagg ctccaacaag      360

cccctgagca gcaatttgag gcggctgctg gaggctggtt ccctcaaact cgatgctgca      420

gccacggcta atggcagagt ggagtccccc gtaaacgttg gctcgaacct ctccttttcc      480

ccgccttccc accacgccca gcagctcagt gttctggcca ggaagttggc cgagaagcag      540

gaacagaatg accaatacac tccaagtaac cgttttatat ggaatcaagg taagtggttg      600

ccaaactcaa ccaccacctg cagcttgtct ccggattcag ccatcctaaa actgaaagct      660

gcagccaatg ccgttctgca ggacaaatct ctcaccagga ctgaggagac catgcgattt      720

gagtcctttt cctccccttt tagctcccag tctgccagtt ctaccttggc cgctttgtcc      780

aagaaggtca gtgaaagaag tttgactcct ggtcaggagc accctccacc ggccagctcc      840

ttcctttccc tggcttctat gacctcctca gcggcccttc tgaaggaggt ggccgcaagg      900

gctgcgggca gtcttctggc tgagaaatca tcgctgctgc ctgaggaccc tctaccgccc      960

ccgccttcag agaagaaacc agaaaaagtc actccgccac ctccaccgcc acctccacca     1020

cctccaccac caccaccaca atccctggaa ttattattac tcccagttcc taagggaaga     1080

gtttctaaac cctccaattc agcctcagaa gaggaaagtg gaaagccttt ccagtgtcca     1140

atatgtggtt tggttattaa aaggaagagt tactggaagc ggcacatggt gattcacaca     1200

ggtttaaaaa gtcatcagtg tccgctctgt ccattccggt gtgctcgcaa ggacaatctc     1260

aaatcccaca tgaaggttca tcagcaccag gatcggggag agacctttca gtgccagctg     1320

tgccctttta cttcctcacg ccacttcagc ctgaaactcc acatgcgttg ccatcagcac     1380

ttcctgagga cagaagccaa ggtgagagag gagatcccag acccagatgt caagggatct     1440

ccccacctca gtgacagtgc ctgcctgggg cagcaaaggg aaggaggagg gacagagcta     1500

gtggggacca tgatgacgtc taacactcca gagaggacta gccagggagg ggctggcgtc     1560

tcgcctttgc tggtgagaga ggaacccaag gaagataacg gcctgcccac ctcctttact     1620

ttgaatgctg ccgacaggcc cgccaaccac acaaagctga aagacccctc cgagtatgtg     1680

gccaacagtg cgtcagcatt gttcagccag gacatctctg ttaagatggc gtctgatttt     1740

ctcatgaagc tgtcagctgc aaatcagaag gagcccatga atcttaattt taaagtgaga     1800

gaggagccta aggaagggga gtccctaagc acgactttgc ctcggtccag ctatgtgttc     1860

agcccggaat ctgaagtgtc agccccaggc gtctctgagg acgcactaaa gccccaggaa     1920

gggaagggaa gtgtgctaag gcgggatgtg tcagtcaaag cagcctctga acttctcatg     1980

aaactctcag cggaaagcta caaggaaaca cagatggtga agattagaga ggaacccatg     2040

gaggttgaca tccaggactc ccatgtctcg atatcaccca gccggaatgt tggctacagc     2100

actttaatcg ggcgagagag aaccgaaccc ttacagaaga tgccagaggg cagagtaccc     2160

ccagagagaa acctcttcag tcaggatatc tctgtgaaaa tggcttccga gctcctcttt     2220

caactgtcag aaaaagtgag caaagagcac aatcatacaa aagaaaacac catccggacc     2280

acgaccagcc ctttcttttc agaagacaca tttagacaat caccattcac ctccaattca     2340

aaagaactgc tgcccagtga ctccgtgctg cacggaagaa tatcagctcc agaaacagaa     2400

aagatagtcc tagaggcagg aaatggatta ccatcctgga aattcaatga ccagcttttt     2460

ccctgtgacg tgtgtgggaa agtgtttggc cgacagcaga cattgtcccg acacctctcg     2520

ctgcacacag aggaaagaaa atacaaatgc cacttgtgcc cctatgctgc taagtgccgt     2580

gcaaatctga accagcactt gaccgtccat tccgtgaagc tggtgagtac agacaccgag     2640

gacattgtca gcgccgtcac ctctgaaggc agtgatggga agaaacatcc ttattattac     2700

agttgtcacg tgtgtggatt tgagaccgag ctcaatgtcc agtttgtcag ccacatgtca     2760

ctccacgtgg acaaggagca gtggatgttt tcgatctgct gcactgcctg cgacttcgtc     2820

accatggagg aagcagagat aaagactcac attggcacca agcacacagg ggaagacagg     2880

aagaccccca gcgaatcaaa tagcccctct tcatcctccc tctcagctct gagtgattca     2940

gccaacagca aagatgattc agatggctcc cagaaaaaca agggcgggaa caatctgctg     3000

gtcatctctg tcatgcctgg gagccagccc tcactgaaca gtgaggaaaa gccagagaaa     3060

gggttcgaat gtgttttttg caactttgtc tgcaagacga agaacatgtt tgagcgtcat     3120

ctgcagatac acctcatcac ccggatgttt gagtgtgatg tgtgccacaa gttcatgaag     3180

acccccgaac agctgctgga gcataagaaa tgccacactg tccccaccgg tgggctcaag     3240

acgcgtacgc ggccgctcga gcagaaactc atctcagaag aggatctggc agcaaatgat     3300

atcctggatt acaaggatga cgacgataag gtttaa                               3336


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA sequence

<400>  20
gtctctggag gaccggatcc agg                                               23


<210>  21
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ss telomeric G rich oligo

<400>  21
ttagggttag ggttaggg                                                     18


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ss telomeric C rich oligo

<400>  22
ccctaaccct aaccctaa                                                     18


<210>  23
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ss pentaprobe 3

<400>  23
cgctctattc tactgtcctg tgcattcaat cgttgagttc gatctagtct cgtctaaccc       60

tcccctgctc cgctggtctg gcctcgccta tcctacccat                            100


<210>  24
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ss pentaprobe 9

<400>  24
atgggtagga taggcgaggc cagaccagcg gagcagggga gggttagacg agactagatc       60

gaactcaacg attgaatgca caggacagta gaatagagcg                            100


<210>  25
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fluorophore conjugated centromere-telomere PNA probe

<400>  25
aaactagaca gaagcat                                                      17


<210>  26
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly 
1               5                   10                  15      


Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro 
            20                  25                  30          


Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro 
        35                  40                  45              


Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe 
    50                  55                  60                  


Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile 
65                  70                  75                  80  


Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp 
                85                  90                  95      


Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp 
            100                 105                 110         


Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val 
        115                 120                 125             


Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe 
    130                 135                 140                 


Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu 
145                 150                 155                 160 


Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro 
                165                 170                 175     


Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly 
            180                 185                 190         


Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala 
        195                 200                 205             


Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly 
    210                 215                 220                 


Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser 
225                 230                 235                 240 


Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr 
                245                 250                 255     


Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu 
            260                 265                 270 


<210>  27
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Val Asp Met Met Asp Leu Pro Arg Ser Arg Ile Asn Ala Gly Met 
1               5                   10                  15      


Leu Ala Gln Phe Ile Asp Lys Pro Val Cys Phe Val Gly Arg Leu Glu 
            20                  25                  30          


Lys Ile His Pro Thr Gly Lys Met Phe Ile Leu Ser Asp Gly Glu Gly 
        35                  40                  45              


Lys Asn Gly Thr Ile Glu Leu Met Glu Pro Leu Asp Glu Glu Ile Ser 
    50                  55                  60                  


Gly Ile Val Glu Val Val Gly Arg Val Thr Ala Lys Ala Thr Ile Leu 
65                  70                  75                  80  


Cys Thr Ser Tyr Val Gln Phe Lys Glu Asp Ser His Pro Phe Asp Leu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Ala Val Lys Ile Ile His Asp Phe Pro Gln Phe 
            100                 105                 110         


Tyr Pro Leu Gly Ile Val Gln His Asp 
        115                 120     


