                         SEQUENCE LISTING

<110>  University College Cardiff Consultants Limited
 
<120>  An anti-mitotic agent

<130>  0180AP/WO

<150>  GB1908208.0
<151>  2019-06-10

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1

His His Asp His Asp His His Ser Asp His Glu His His Ser Asp 
1               5                   10                  15  


<210>  2
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Pro Arg Lys Gly Phe Met Tyr Ser Arg Asn Thr Asn Glu 
1               5                   10                  


<210>  3
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Ser Cys Leu Ile His Thr Ser Glu Lys Lys Ala Glu Ile Pro Pro 
1               5                   10                  15      


Lys Thr Tyr Ser Leu Gln Ile Ala Trp Val Gly Gly Phe Ile Ala Ile 
            20                  25                  30          


Ser Ile Ile Ser Phe Leu Ser Leu Leu Gly Val Ile Leu Val Pro Leu 
        35                  40                  45              


Met Asn 
    50  


<210>  4
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Leu Ile His Thr Ser Glu Lys Lys Ala Glu Ile Pro 
1               5                   10              


<210>  5
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  5

His Ser His His Asn His Ala Ala Ser Gly Lys Asn Lys Arg Lys Ala 
1               5                   10                  15      


Leu Cys Pro Asp His Asp Ser Asp Ser Ser Gly Lys Asp Pro Arg Asn 
            20                  25                  30          


Ser Gln Gly Lys Gly Ala His Arg Pro Glu His Ala Ser Gly Arg Arg 
        35                  40                  45              


Asn Val Lys Asp Ser Val Ser Ala Ser Glu Val Thr Ser Thr Val Tyr 
    50                  55                  60                  


Asn Thr Val Ser Glu Gly Thr His Phe Leu Glu Thr Ile Glu Thr Pro 
65                  70                  75                  80  


Arg Pro Gly Lys Leu Phe Pro Lys Asp Val Ser Ser Ser Thr Pro Pro 
                85                  90                  95      


Ser Val Thr Ser Lys Ser Arg Val Ser Arg Leu Ala Gly Arg Lys Thr 
            100                 105                 110         


Asn Glu Ser Val Ser Glu Pro Arg Lys Gly Phe Met Tyr Ser Arg Asn 
        115                 120                 125             


Thr Asn Glu Asn Pro Gln Glu 
    130                 135 


<210>  6
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  6

Asn Tyr Leu Cys Pro Ala Ile Ile Asn Gln Ile Asp Ala Arg Ser Cys 
1               5                   10                  15      


Leu Ile His Thr Ser Glu Lys Lys Ala Glu Ile Pro Pro Lys Thr Tyr 
            20                  25                  30          


Ser Leu Gln Ile Ala Trp Val Gly Gly Phe Ile Ala Ile Ser Ile Ile 
        35                  40                  45              


Ser Phe 
    50  


<210>  7
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Ser His His His Ser His Ser His Glu Glu Pro Ala Met Glu Met 
1               5                   10                  15      


Lys Arg Gly Pro Leu Phe Ser His Leu Ser Ser Gln Asn Ile Glu Glu 
            20                  25                  30          


Ser Ala Tyr Phe Asp Ser Thr Trp Lys 
        35                  40      


<210>  8
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Glu Gly Leu Ser Ser Gly 
1               5           


<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  9

His Tyr Ala Glu Asn Val Ser Met 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Ile Val Phe Arg Ile Asn Phe 
1               5               


<210>  11
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Glu Pro Ser Lys Phe Ser Lys Gln Ala Ala Glu Asn Glu 
1               5                   10                  


<210>  12
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Lys Glu Thr Val Glu Val Ser Val Lys Ser Asp Asp Lys His Met 
1               5                   10                  15      


His Asp His Asn His Arg Leu Arg His His His Arg Leu His His His 
            20                  25                  30          


Leu Asp His Asn Thr His His Phe His Asn Asp Ser Ile Thr Pro Ser 
        35                  40                  45              


Glu Arg Gly Glu Pro Ser Asn Glu Pro Ser Thr Glu Thr Asn Lys Thr 
    50                  55                  60                  


Gln Glu Gln Ser Asp Val Lys Leu Pro Lys Gly Lys Arg Lys Lys Lys 
65                  70                  75                  80  


Gly Arg Lys Ser Asn Glu Asn Ser Glu Val Ile Thr Pro Gly Phe Pro 
                85                  90                  95      


<210>  13
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Asp Leu Asp Pro Asp Asn Glu Gly Glu Leu Arg His Thr Arg Lys 
1               5                   10                  15      


Arg Glu Ala Pro His Val Lys Asn Asn Ala Ile Ile Ser Leu Arg 
            20                  25                  30      


<210>  14
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu His Arg Gln His Arg Gly Met Thr Glu Leu Glu Pro Ser Lys Phe 
1               5                   10                  15      


Ser Lys Gln Ala Ala Glu Asn Glu Lys Lys Tyr Tyr Ile Glu Lys Leu 
            20                  25                  30          


Phe Glu Arg Tyr Gly Glu Asn Gly Arg Leu Ser Phe Phe Gly Leu Glu 
        35                  40                  45              


Lys Leu 
    50  


<210>  15
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Gly His Asp His Ser His Gln His Ala His Gly His Gly His Ser 
1               5                   10                  15      


His Gly His Glu Ser Asn Lys Phe Leu Glu Glu Tyr Asp Ala Val Leu 
            20                  25                  30          


Lys 
    


<210>  16
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Ala Gly Leu Thr Gly Gly 
1               5           


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Tyr Ala Asn Asn Ile Thr Leu Trp Asn 
1               5                   10  


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Ile Val Phe Asp Ile Gln Phe 
1               5               


<210>  19
<211>  755
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Arg Lys Leu Ser Val Ile Leu Ile Leu Thr Phe Ala Leu Ser 
1               5                   10                  15      


Val Thr Asn Pro Leu His Glu Leu Lys Ala Ala Ala Phe Pro Gln Thr 
            20                  25                  30          


Thr Glu Lys Ile Ser Pro Asn Trp Glu Ser Gly Ile Asn Val Asp Leu 
        35                  40                  45              


Ala Ile Ser Thr Arg Gln Tyr His Leu Gln Gln Leu Phe Tyr Arg Tyr 
    50                  55                  60                  


Gly Glu Asn Asn Ser Leu Ser Val Glu Gly Phe Arg Lys Leu Leu Gln 
65                  70                  75                  80  


Asn Ile Gly Ile Asp Lys Ile Lys Arg Ile His Ile His His Asp His 
                85                  90                  95      


Asp His His Ser Asp His Glu His His Ser Asp His Glu Arg His Ser 
            100                 105                 110         


Asp His Glu His His Ser Glu His Glu His His Ser Asp His Asp His 
        115                 120                 125             


His Ser His His Asn His Ala Ala Ser Gly Lys Asn Lys Arg Lys Ala 
    130                 135                 140                 


Leu Cys Pro Asp His Asp Ser Asp Ser Ser Gly Lys Asp Pro Arg Asn 
145                 150                 155                 160 


Ser Gln Gly Lys Gly Ala His Arg Pro Glu His Ala Ser Gly Arg Arg 
                165                 170                 175     


Asn Val Lys Asp Ser Val Ser Ala Ser Glu Val Thr Ser Thr Val Tyr 
            180                 185                 190         


Asn Thr Val Ser Glu Gly Thr His Phe Leu Glu Thr Ile Glu Thr Pro 
        195                 200                 205             


Arg Pro Gly Lys Leu Phe Pro Lys Asp Val Ser Ser Ser Thr Pro Pro 
    210                 215                 220                 


Ser Val Thr Ser Lys Ser Arg Val Ser Arg Leu Ala Gly Arg Lys Thr 
225                 230                 235                 240 


Asn Glu Ser Val Ser Glu Pro Arg Lys Gly Phe Met Tyr Ser Arg Asn 
                245                 250                 255     


Thr Asn Glu Asn Pro Gln Glu Cys Phe Asn Ala Ser Lys Leu Leu Thr 
            260                 265                 270         


Ser His Gly Met Gly Ile Gln Val Pro Leu Asn Ala Thr Glu Phe Asn 
        275                 280                 285             


Tyr Leu Cys Pro Ala Ile Ile Asn Gln Ile Asp Ala Arg Ser Cys Leu 
    290                 295                 300                 


Ile His Thr Ser Glu Lys Lys Ala Glu Ile Pro Pro Lys Thr Tyr Ser 
305                 310                 315                 320 


Leu Gln Ile Ala Trp Val Gly Gly Phe Ile Ala Ile Ser Ile Ile Ser 
                325                 330                 335     


Phe Leu Ser Leu Leu Gly Val Ile Leu Val Pro Leu Met Asn Arg Val 
            340                 345                 350         


Phe Phe Lys Phe Leu Leu Ser Phe Leu Val Ala Leu Ala Val Gly Thr 
        355                 360                 365             


Leu Ser Gly Asp Ala Phe Leu His Leu Leu Pro His Ser His Ala Ser 
    370                 375                 380                 


His His His Ser His Ser His Glu Glu Pro Ala Met Glu Met Lys Arg 
385                 390                 395                 400 


Gly Pro Leu Phe Ser His Leu Ser Ser Gln Asn Ile Glu Glu Ser Ala 
                405                 410                 415     


Tyr Phe Asp Ser Thr Trp Lys Gly Leu Thr Ala Leu Gly Gly Leu Tyr 
            420                 425                 430         


Phe Met Phe Leu Val Glu His Val Leu Thr Leu Ile Lys Gln Phe Lys 
        435                 440                 445             


Asp Lys Lys Lys Lys Asn Gln Lys Lys Pro Glu Asn Asp Asp Asp Val 
    450                 455                 460                 


Glu Ile Lys Lys Gln Leu Ser Lys Tyr Glu Ser Gln Leu Ser Thr Asn 
465                 470                 475                 480 


Glu Glu Lys Val Asp Thr Asp Asp Arg Thr Glu Gly Tyr Leu Arg Ala 
                485                 490                 495     


Asp Ser Gln Glu Pro Ser His Phe Asp Ser Gln Gln Pro Ala Val Leu 
            500                 505                 510         


Glu Glu Glu Glu Val Met Ile Ala His Ala His Pro Gln Glu Val Tyr 
        515                 520                 525             


Asn Glu Tyr Val Pro Arg Gly Cys Lys Asn Lys Cys His Ser His Phe 
    530                 535                 540                 


His Asp Thr Leu Gly Gln Ser Asp Asp Leu Ile His His His His Asp 
545                 550                 555                 560 


Tyr His His Ile Leu His His His His His Gln Asn His His Pro His 
                565                 570                 575     


Ser His Ser Gln Arg Tyr Ser Arg Glu Glu Leu Lys Asp Ala Gly Val 
            580                 585                 590         


Ala Thr Leu Ala Trp Met Val Ile Met Gly Asp Gly Leu His Asn Phe 
        595                 600                 605             


Ser Asp Gly Leu Ala Ile Gly Ala Ala Phe Thr Glu Gly Leu Ser Ser 
    610                 615                 620                 


Gly Leu Ser Thr Ser Val Ala Val Phe Cys His Glu Leu Pro His Glu 
625                 630                 635                 640 


Leu Gly Asp Phe Ala Val Leu Leu Lys Ala Gly Met Thr Val Lys Gln 
                645                 650                 655     


Ala Val Leu Tyr Asn Ala Leu Ser Ala Met Leu Ala Tyr Leu Gly Met 
            660                 665                 670         


Ala Thr Gly Ile Phe Ile Gly His Tyr Ala Glu Asn Val Ser Met Trp 
        675                 680                 685             


Ile Phe Ala Leu Thr Ala Gly Leu Phe Met Tyr Val Ala Leu Val Asp 
    690                 695                 700                 


Met Val Pro Glu Met Leu His Asn Asp Ala Ser Asp His Gly Cys Ser 
705                 710                 715                 720 


Arg Trp Gly Tyr Phe Phe Leu Gln Asn Ala Gly Met Leu Leu Gly Phe 
                725                 730                 735     


Gly Ile Met Leu Leu Ile Ser Ile Phe Glu His Lys Ile Val Phe Arg 
            740                 745                 750         


Ile Asn Phe 
        755 


<210>  20
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Val His Met His Thr Lys Phe Cys Leu Ile Cys Leu Leu Thr 
1               5                   10                  15      


Phe Ile Phe His His Cys Asn His Cys His Glu Glu His Asp His Gly 
            20                  25                  30          


Pro Glu Ala Leu His Arg Gln His Arg Gly Met Thr Glu Leu Glu Pro 
        35                  40                  45              


Ser Lys Phe Ser Lys Gln Ala Ala Glu Asn Glu Lys Lys Tyr Tyr Ile 
    50                  55                  60                  


Glu Lys Leu Phe Glu Arg Tyr Gly Glu Asn Gly Arg Leu Ser Phe Phe 
65                  70                  75                  80  


Gly Leu Glu Lys Leu Leu Thr Asn Leu Gly Leu Gly Glu Arg Lys Val 
                85                  90                  95      


Val Glu Ile Asn His Glu Asp Leu Gly His Asp His Val Ser His Leu 
            100                 105                 110         


Asp Ile Leu Ala Val Gln Glu Gly Lys His Phe His Ser His Asn His 
        115                 120                 125             


Gln His Ser His Asn His Leu Asn Ser Glu Asn Gln Thr Val Thr Ser 
    130                 135                 140                 


Val Ser Thr Lys Arg Asn His Lys Cys Asp Pro Glu Lys Glu Thr Val 
145                 150                 155                 160 


Glu Val Ser Val Lys Ser Asp Asp Lys His Met His Asp His Asn His 
                165                 170                 175     


Arg Leu Arg His His His Arg Leu His His His Leu Asp His Asn Asn 
            180                 185                 190         


Thr His His Phe His Asn Asp Ser Ile Thr Pro Ser Glu Arg Gly Glu 
        195                 200                 205             


Pro Ser Asn Glu Pro Ser Thr Glu Thr Asn Lys Thr Gln Glu Gln Ser 
    210                 215                 220                 


Asp Val Lys Leu Pro Lys Gly Lys Arg Lys Lys Lys Gly Arg Lys Ser 
225                 230                 235                 240 


Asn Glu Asn Ser Glu Val Ile Thr Pro Gly Phe Pro Pro Asn His Asp 
                245                 250                 255     


Gln Gly Glu Gln Tyr Glu His Asn Arg Val His Lys Pro Asp Arg Val 
            260                 265                 270         


His Asn Pro Gly His Ser His Val His Leu Pro Glu Arg Asn Gly His 
        275                 280                 285             


Asp Pro Gly Arg Gly His Gln Asp Leu Asp Pro Asp Asn Glu Gly Glu 
    290                 295                 300                 


Leu Arg His Thr Arg Lys Arg Glu Ala Pro His Val Lys Asn Asn Ala 
305                 310                 315                 320 


Ile Ile Ser Leu Arg Lys Asp Leu Asn Glu Asp Asp His His His Glu 
                325                 330                 335     


Cys Leu Asn Val Thr Gln Leu Leu Lys Tyr Tyr Gly His Gly Ala Asn 
            340                 345                 350         


Ser Pro Ile Ser Thr Asp Leu Phe Thr Tyr Leu Cys Pro Ala Leu Leu 
        355                 360                 365             


Tyr Gln Ile Asp Ser Arg Leu Cys Ile Glu His Phe Asp Lys Leu Leu 
    370                 375                 380                 


Val Glu Asp Ile Asn Lys Asp Lys Asn Leu Val Pro Glu Asp Glu Ala 
385                 390                 395                 400 


Asn Ile Gly Ala Ser Ala Trp Ile Cys Gly Ile Ile Ser Ile Thr Val 
                405                 410                 415     


Ile Ser Leu Leu Ser Leu Leu Gly Val Ile Leu Val Pro Ile Ile Asn 
            420                 425                 430         


Gln Gly Cys Phe Lys Phe Leu Leu Thr Phe Leu Val Ala Leu Ala Val 
        435                 440                 445             


Gly Thr Met Ser Gly Asp Ala Leu Leu His Leu Leu Pro His Ser Gln 
    450                 455                 460                 


Gly Gly His Asp His Ser His Gln His Ala His Gly His Gly His Ser 
465                 470                 475                 480 


His Gly His Glu Ser Asn Lys Phe Leu Glu Glu Tyr Asp Ala Val Leu 
                485                 490                 495     


Lys Gly Leu Val Ala Leu Gly Gly Ile Tyr Leu Leu Phe Ile Ile Glu 
            500                 505                 510         


His Cys Ile Arg Met Phe Lys His Tyr Lys Gln Gln Arg Gly Lys Gln 
        515                 520                 525             


Lys Trp Phe Met Lys Gln Asn Thr Glu Glu Ser Thr Ile Gly Arg Lys 
    530                 535                 540                 


Leu Ser Asp His Lys Leu Asn Asn Thr Pro Asp Ser Asp Trp Leu Gln 
545                 550                 555                 560 


Leu Lys Pro Leu Ala Gly Thr Asp Asp Ser Val Val Ser Glu Asp Arg 
                565                 570                 575     


Leu Asn Glu Thr Glu Leu Thr Asp Leu Glu Gly Gln Gln Glu Ser Pro 
            580                 585                 590         


Pro Lys Asn Tyr Leu Cys Ile Glu Glu Glu Lys Ile Ile Asp His Ser 
        595                 600                 605             


His Ser Asp Gly Leu His Thr Ile His Glu His Asp Leu His Ala Ala 
    610                 615                 620                 


Ala His Asn His His Gly Glu Asn Lys Thr Val Leu Arg Lys His Asn 
625                 630                 635                 640 


His Gln Trp His His Lys His Ser His His Ser His Gly Pro Cys His 
                645                 650                 655     


Ser Gly Ser Asp Leu Lys Glu Thr Gly Ile Ala Asn Ile Ala Trp Met 
            660                 665                 670         


Val Ile Met Gly Asp Gly Ile His Asn Phe Ser Asp Gly Leu Ala Ile 
        675                 680                 685             


Gly Ala Ala Phe Ser Ala Gly Leu Thr Gly Gly Ile Ser Thr Ser Ile 
    690                 695                 700                 


Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe Ala Val 
705                 710                 715                 720 


Leu Leu Lys Ala Gly Met Thr Val Lys Gln Ala Ile Val Tyr Asn Leu 
                725                 730                 735     


Leu Ser Ala Met Met Ala Tyr Ile Gly Met Leu Ile Gly Thr Ala Val 
            740                 745                 750         


Gly Gln Tyr Ala Asn Asn Ile Thr Leu Trp Ile Phe Ala Val Thr Ala 
        755                 760                 765             


Gly Met Phe Leu Tyr Val Ala Leu Val Asp Met Leu Pro Glu Met Leu 
    770                 775                 780                 


His Gly Asp Gly Asp Asn Glu Glu His Gly Phe Cys Pro Val Gly Gln 
785                 790                 795                 800 


Phe Ile Leu Gln Asn Leu Gly Leu Leu Phe Gly Phe Ala Ile Met Leu 
                805                 810                 815     


Val Ile Ala Leu Tyr Glu Asp Lys Ile Val Phe Asp Ile Gln Phe 
            820                 825                 830     


