﻿               SEQUENCE LISTING

<110> Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

<120> Heteroaromatic Inhibitors of Astacin Proteinases

<130> PBD143WO

<160> 10

<170> BiSSAP 1.3.6

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Substrate

<220> 
<221> SITE
<222> 7..7
<223> Xaa corresponds to Lys modified with Dnp (2,4-dinitrophenyl)

<400> 1
Tyr Val Ala Glu Ala Pro Xaa Gly 
1               5               

<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Substrate

<220> 
<221> SITE
<222> 7..7
<223> Xaa corresponds to Lys modified with Dnp (2,4-dinitrophenyl)

<400> 2
Tyr Val Ala Asp Ala Pro Xaa Gly 
1               5               

<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Substrate

<220> 
<221> SITE
<222> 3
<223> Xaa corresponds to (DapDnp) wherein Dnp = 2,4-dinitrophenyl; Dap
      = 2,3-diaminopropionic acid;

<220> 
<221> SITE
<222> 8
<223> Xaa corresponds to Mca = 7-methoxy coumarin

<400> 3
Arg Ala Xaa Leu Gly Leu Pro Xaa 
1               5               

<210> 4
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> Xaa corresponds to (DapDnp) wherein Dnp = 2,4-dinitrophenyl; Dap
      = 2,3-diaminopropionic acid;

<220> 
<223> Substate

<220> 
<221> SITE
<222> 12
<223> Xaa corresponds to Abz = 2-aminobenzoyl

<400> 4
Xaa Arg Ser Ser Ser Arg Val Ala Asn Ala Leu Xaa 
1               5                   10          

<210> 5
<211> 701
<212> PRT
<213> Homo sapiens


<220> 
<223> hMeprin_beta

<400> 5
Met Asp Leu Trp Asn Leu Ser Trp Phe Leu Phe Leu Asp Ala Leu Leu 
1               5                   10                  15      
Val Ile Ser Gly Leu Ala Thr Pro Glu Asn Phe Asp Val Asp Gly Gly 
            20                  25                  30          
Met Asp Gln Asp Ile Phe Asp Ile Asn Glu Gly Leu Gly Leu Asp Leu 
        35                  40                  45              
Phe Glu Gly Asp Ile Arg Leu Asp Arg Ala Gln Ile Arg Asn Ser Ile 
    50                  55                  60                  
Ile Gly Glu Lys Tyr Arg Trp Pro His Thr Ile Pro Tyr Val Leu Glu 
65                  70                  75                  80  
Asp Ser Leu Glu Met Asn Ala Lys Gly Val Ile Leu Asn Ala Phe Glu 
                85                  90                  95      
Arg Tyr Arg Leu Lys Thr Cys Ile Asp Phe Lys Pro Trp Ala Gly Glu 
            100                 105                 110         
Thr Asn Tyr Ile Ser Val Phe Lys Gly Ser Gly Cys Trp Ser Ser Val 
        115                 120                 125             
Gly Asn Arg Arg Val Gly Lys Gln Glu Leu Ser Ile Gly Ala Asn Cys 
    130                 135                 140                 
Asp Arg Ile Ala Thr Val Gln His Glu Phe Leu His Ala Leu Gly Phe 
145                 150                 155                 160 
Trp His Glu Gln Ser Arg Ser Asp Arg Asp Asp Tyr Val Arg Ile Met 
                165                 170                 175     
Trp Asp Arg Ile Leu Ser Gly Arg Glu His Asn Phe Asn Thr Tyr Ser 
            180                 185                 190         
Asp Asp Ile Ser Asp Ser Leu Asn Val Pro Tyr Asp Tyr Thr Ser Val 
        195                 200                 205             
Met His Tyr Ser Lys Thr Ala Phe Gln Asn Gly Thr Glu Pro Thr Ile 
    210                 215                 220                 
Val Thr Arg Ile Ser Asp Phe Glu Asp Val Ile Gly Gln Arg Met Asp 
225                 230                 235                 240 
Phe Ser Asp Ser Asp Leu Leu Lys Leu Asn Gln Leu Tyr Asn Cys Ser 
                245                 250                 255     
Ser Ser Leu Ser Phe Met Asp Ser Cys Ser Phe Glu Leu Glu Asn Val 
            260                 265                 270         
Cys Gly Met Ile Gln Ser Ser Gly Asp Asn Ala Asp Trp Gln Arg Val 
        275                 280                 285             
Ser Gln Val Pro Arg Gly Pro Glu Ser Asp His Ser Asn Met Gly Gln 
    290                 295                 300                 
Cys Gln Gly Ser Gly Phe Phe Met His Phe Asp Ser Ser Ser Val Asn 
305                 310                 315                 320 
Val Gly Ala Thr Ala Val Leu Glu Ser Arg Thr Leu Tyr Pro Lys Arg 
                325                 330                 335     
Gly Phe Gln Cys Leu Gln Phe Tyr Leu Tyr Asn Ser Gly Ser Glu Ser 
            340                 345                 350         
Asp Gln Leu Asn Ile Tyr Ile Arg Glu Tyr Ser Ala Asp Asn Val Asp 
        355                 360                 365             
Gly Asn Leu Thr Leu Val Glu Glu Ile Lys Glu Ile Pro Thr Gly Ser 
    370                 375                 380                 
Trp Gln Leu Tyr His Val Thr Leu Lys Val Thr Lys Lys Phe Arg Val 
385                 390                 395                 400 
Val Phe Glu Gly Arg Lys Gly Ser Gly Ala Ser Leu Gly Gly Leu Ser 
                405                 410                 415     
Ile Asp Asp Ile Asn Leu Ser Glu Thr Arg Cys Pro His His Ile Trp 
            420                 425                 430         
His Ile Arg Asn Phe Thr Gln Phe Ile Gly Ser Pro Asn Gly Thr Leu 
        435                 440                 445             
Tyr Ser Pro Pro Phe Tyr Ser Ser Lys Gly Tyr Ala Phe Gln Ile Tyr 
    450                 455                 460                 
Leu Asn Leu Ala His Val Thr Asn Ala Gly Ile Tyr Phe His Leu Ile 
465                 470                 475                 480 
Ser Gly Ala Asn Asp Asp Gln Leu Gln Trp Pro Cys Pro Trp Gln Gln 
                485                 490                 495     
Ala Thr Met Thr Leu Leu Asp Gln Asn Pro Asp Ile Arg Gln Arg Met 
            500                 505                 510         
Ser Asn Gln Arg Ser Ile Thr Thr Asp Pro Phe Met Thr Thr Asp Asn 
        515                 520                 525             
Gly Asn Tyr Phe Trp Asp Arg Pro Ser Lys Val Gly Thr Val Ala Leu 
    530                 535                 540                 
Phe Ser Asn Gly Thr Gln Phe Arg Arg Gly Gly Gly Tyr Gly Thr Ser 
545                 550                 555                 560 
Ala Phe Ile Thr His Glu Arg Leu Lys Ser Arg Asp Phe Ile Lys Gly 
                565                 570                 575     
Asp Asp Val Tyr Ile Leu Leu Thr Val Glu Asp Ile Ser His Leu Asn 
            580                 585                 590         
Ser Thr Gln Ile Gln Leu Thr Pro Ala Pro Ser Val Gln Asp Leu Cys 
        595                 600                 605             
Ser Lys Thr Thr Cys Lys Asn Asp Gly Val Cys Thr Val Arg Asp Gly 
    610                 615                 620                 
Lys Ala Glu Cys Arg Cys Gln Ser Gly Glu Asp Trp Trp Tyr Met Gly 
625                 630                 635                 640 
Glu Arg Cys Glu Lys Arg Gly Ser Thr Arg Asp Thr Ile Val Ile Ala 
                645                 650                 655     
Val Ser Ser Thr Val Ala Val Phe Ala Leu Met Leu Ile Ile Thr Leu 
            660                 665                 670         
Val Ser Val Tyr Cys Thr Arg Lys Lys Tyr Arg Glu Arg Met Ser Ser 
        675                 680                 685             
Asn Arg Pro Asn Leu Thr Pro Gln Asn Gln His Ala Phe 
    690                 695                 700     

<210> 6
<211> 746
<212> PRT
<213> Homo sapiens


<220> 
<223> hMeprin_alpha

<400> 6
Met Ala Trp Ile Arg Ser Thr Cys Ile Leu Phe Phe Thr Leu Leu Phe 
1               5                   10                  15      
Ala His Ile Ala Ala Val Pro Ile Lys Tyr Leu Pro Glu Glu Asn Val 
            20                  25                  30          
His Asp Ala Asp Phe Gly Glu Gln Lys Asp Ile Ser Glu Ile Asn Leu 
        35                  40                  45              
Ala Ala Gly Leu Asp Leu Phe Gln Gly Asp Ile Leu Leu Gln Lys Ser 
    50                  55                  60                  
Arg Asn Gly Leu Arg Asp Pro Asn Thr Arg Trp Thr Phe Pro Ile Pro 
65                  70                  75                  80  
Tyr Ile Leu Ala Asp Asn Leu Gly Leu Asn Ala Lys Gly Ala Ile Leu 
                85                  90                  95      
Tyr Ala Phe Glu Met Phe Arg Leu Lys Ser Cys Val Asp Phe Lys Pro 
            100                 105                 110         
Tyr Glu Gly Glu Ser Ser Tyr Ile Ile Phe Gln Gln Phe Asp Gly Cys 
        115                 120                 125             
Trp Ser Glu Val Gly Asp Gln His Val Gly Gln Asn Ile Ser Ile Gly 
    130                 135                 140                 
Gln Gly Cys Ala Tyr Lys Ala Ile Ile Glu His Glu Ile Leu His Ala 
145                 150                 155                 160 
Leu Gly Phe Tyr His Glu Gln Ser Arg Thr Asp Arg Asp Asp Tyr Val 
                165                 170                 175     
Asn Ile Trp Trp Asp Gln Ile Leu Ser Gly Tyr Gln His Asn Phe Asp 
            180                 185                 190         
Thr Tyr Asp Asp Ser Leu Ile Thr Asp Leu Asn Thr Pro Tyr Asp Tyr 
        195                 200                 205             
Glu Ser Leu Met His Tyr Gln Pro Phe Ser Phe Asn Lys Asn Ala Ser 
    210                 215                 220                 
Val Pro Thr Ile Thr Ala Lys Ile Pro Glu Phe Asn Ser Ile Ile Gly 
225                 230                 235                 240 
Gln Arg Leu Asp Phe Ser Ala Ile Asp Leu Glu Arg Leu Asn Arg Met 
                245                 250                 255     
Tyr Asn Cys Thr Thr Thr His Thr Leu Leu Asp His Cys Thr Phe Glu 
            260                 265                 270         
Lys Ala Asn Ile Cys Gly Met Ile Gln Gly Thr Arg Asp Asp Thr Asp 
        275                 280                 285             
Trp Ala His Gln Asp Ser Ala Gln Ala Gly Glu Val Asp His Thr Leu 
    290                 295                 300                 
Leu Gly Gln Cys Thr Gly Ala Gly Tyr Phe Met Gln Phe Ser Thr Ser 
305                 310                 315                 320 
Ser Gly Ser Ala Glu Glu Ala Ala Leu Leu Glu Ser Arg Ile Leu Tyr 
                325                 330                 335     
Pro Lys Arg Lys Gln Gln Cys Leu Gln Phe Phe Tyr Lys Met Thr Gly 
            340                 345                 350         
Ser Pro Ser Asp Arg Leu Val Val Trp Val Arg Arg Asp Asp Ser Thr 
        355                 360                 365             
Gly Asn Val Arg Lys Leu Val Lys Val Gln Thr Phe Gln Gly Asp Asp 
    370                 375                 380                 
Asp His Asn Trp Lys Ile Ala His Val Val Leu Lys Glu Glu Gln Lys 
385                 390                 395                 400 
Phe Arg Tyr Leu Phe Gln Gly Thr Lys Gly Asp Pro Gln Asn Ser Thr 
                405                 410                 415     
Gly Gly Ile Tyr Leu Asp Asp Ile Thr Leu Thr Glu Thr Pro Cys Pro 
            420                 425                 430         
Thr Gly Val Trp Thr Val Arg Asn Phe Ser Gln Val Leu Glu Asn Thr 
        435                 440                 445             
Ser Lys Gly Asp Lys Leu Gln Ser Pro Arg Phe Tyr Asn Ser Glu Gly 
    450                 455                 460                 
Tyr Gly Phe Gly Val Thr Leu Tyr Pro Asn Ser Arg Glu Ser Ser Gly 
465                 470                 475                 480 
Tyr Leu Arg Leu Ala Phe His Val Cys Ser Gly Glu Asn Asp Ala Ile 
                485                 490                 495     
Leu Glu Trp Pro Val Glu Asn Arg Gln Val Ile Ile Thr Ile Leu Asp 
            500                 505                 510         
Gln Glu Pro Asp Val Arg Asn Arg Met Ser Ser Ser Met Val Phe Thr 
        515                 520                 525             
Thr Ser Lys Ser His Thr Ser Pro Ala Ile Asn Asp Thr Val Ile Trp 
    530                 535                 540                 
Asp Arg Pro Ser Arg Val Gly Thr Tyr His Thr Asp Cys Asn Cys Phe 
545                 550                 555                 560 
Arg Ser Ile Asp Leu Gly Trp Ser Gly Phe Ile Ser His Gln Met Leu 
                565                 570                 575     
Lys Arg Arg Ser Phe Leu Lys Asn Asp Asp Leu Ile Ile Phe Val Asp 
            580                 585                 590         
Phe Glu Asp Ile Thr His Leu Ser Gln Thr Glu Val Pro Thr Lys Gly 
        595                 600                 605             
Lys Arg Leu Ser Pro Gln Gly Leu Ile Leu Gln Gly Gln Glu Gln Gln 
    610                 615                 620                 
Val Ser Glu Glu Gly Ser Gly Lys Ala Met Leu Glu Glu Ala Leu Pro 
625                 630                 635                 640 
Val Ser Leu Ser Gln Gly Gln Pro Ser Arg Gln Lys Arg Ser Val Glu 
                645                 650                 655     
Asn Thr Gly Pro Leu Glu Asp His Asn Trp Pro Gln Tyr Phe Arg Asp 
            660                 665                 670         
Pro Cys Asp Pro Asn Pro Cys Gln Asn Asp Gly Ile Cys Val Asn Val 
        675                 680                 685             
Lys Gly Met Ala Ser Cys Arg Cys Ile Ser Gly His Ala Phe Phe Tyr 
    690                 695                 700                 
Thr Gly Glu Arg Cys Gln Ala Val Gln Val His Gly Ser Val Leu Gly 
705                 710                 715                 720 
Met Val Ile Gly Gly Thr Ala Gly Val Ile Phe Leu Thr Phe Ser Ile 
                725                 730                 735     
Ile Ala Ile Leu Ser Gln Arg Pro Arg Lys 
            740                 745     

<210> 7
<211> 431
<212> PRT
<213> Homo sapiens


<220> 
<223> hOvastacin

<400> 7
Met Glu Gly Val Gly Gly Leu Trp Pro Trp Val Leu Gly Leu Leu Ser 
1               5                   10                  15      
Leu Pro Gly Val Ile Leu Gly Ala Pro Leu Ala Ser Ser Cys Ala Gly 
            20                  25                  30          
Ala Cys Gly Thr Ser Phe Pro Asp Gly Leu Thr Pro Glu Gly Thr Gln 
        35                  40                  45              
Ala Ser Gly Asp Lys Asp Ile Pro Ala Ile Asn Gln Gly Leu Ile Leu 
    50                  55                  60                  
Glu Glu Thr Pro Glu Ser Ser Phe Leu Ile Glu Gly Asp Ile Ile Arg 
65                  70                  75                  80  
Pro Ser Pro Phe Arg Leu Leu Ser Ala Thr Ser Asn Lys Trp Pro Met 
                85                  90                  95      
Gly Gly Ser Gly Val Val Glu Val Pro Phe Leu Leu Ser Ser Lys Tyr 
            100                 105                 110         
Asp Glu Pro Ser Arg Gln Val Ile Leu Glu Ala Leu Ala Glu Phe Glu 
        115                 120                 125             
Arg Ser Thr Cys Ile Arg Phe Val Thr Tyr Gln Asp Gln Arg Asp Phe 
    130                 135                 140                 
Ile Ser Ile Ile Pro Met Tyr Gly Cys Phe Ser Ser Val Gly Arg Ser 
145                 150                 155                 160 
Gly Gly Met Gln Val Val Ser Leu Ala Pro Thr Cys Leu Gln Lys Gly 
                165                 170                 175     
Arg Gly Ile Val Leu His Glu Leu Met His Val Leu Gly Phe Trp His 
            180                 185                 190         
Glu His Thr Arg Ala Asp Arg Asp Arg Tyr Ile Arg Val Asn Trp Asn 
        195                 200                 205             
Glu Ile Leu Pro Gly Phe Glu Ile Asn Phe Ile Lys Ser Gln Ser Ser 
    210                 215                 220                 
Asn Met Leu Thr Pro Tyr Asp Tyr Ser Ser Val Met His Tyr Gly Arg 
225                 230                 235                 240 
Leu Ala Phe Ser Arg Arg Gly Leu Pro Thr Ile Thr Pro Leu Trp Ala 
                245                 250                 255     
Pro Ser Val His Ile Gly Gln Arg Trp Asn Leu Ser Ala Ser Asp Ile 
            260                 265                 270         
Thr Arg Val Leu Lys Leu Tyr Gly Cys Ser Pro Ser Gly Pro Arg Pro 
        275                 280                 285             
Arg Gly Arg Gly Ser His Ala His Ser Thr Gly Arg Ser Pro Ala Pro 
    290                 295                 300                 
Ala Ser Leu Ser Leu Gln Arg Leu Leu Glu Ala Leu Ser Ala Glu Ser 
305                 310                 315                 320 
Arg Ser Pro Asp Pro Ser Gly Ser Ser Ala Gly Gly Gln Pro Val Pro 
                325                 330                 335     
Ala Gly Pro Gly Glu Ser Pro His Gly Trp Glu Ser Pro Ala Leu Lys 
            340                 345                 350         
Lys Leu Ser Ala Glu Ala Ser Ala Arg Gln Pro Gln Thr Leu Ala Ser 
        355                 360                 365             
Ser Pro Arg Ser Arg Pro Gly Ala Gly Ala Pro Gly Val Ala Gln Glu 
    370                 375                 380                 
Gln Ser Trp Leu Ala Gly Val Ser Thr Lys Pro Thr Val Pro Ser Ser 
385                 390                 395                 400 
Glu Ala Gly Ile Gln Pro Val Pro Val Gln Gly Ser Pro Ala Leu Pro 
                405                 410                 415     
Gly Gly Cys Val Pro Arg Asn His Phe Lys Gly Met Ser Glu Asp 
            420                 425                 430     

<210> 8
<211> 592
<212> PRT
<213> Caenorhabditis elegans


<220> 
<223> DPY31_C.elegans

<400> 8
Met His Lys Ile Phe Ile Ile Phe Gly Leu Leu Ser Leu Cys Ala Ala 
1               5                   10                  15      
His Ser Leu Arg Asp Leu Ser Asn Lys Asp Glu Glu Asp Pro Pro Ser 
            20                  25                  30          
Ser Ala Pro Gly Val Arg Lys Arg Arg Met Met Ser Glu Glu Asp Gln 
        35                  40                  45              
Lys Thr Val Asp Tyr Tyr Met Asp Lys Leu Asn Lys Leu Ala Asp Glu 
    50                  55                  60                  
Lys His Pro Glu Glu Ile Glu Arg His Lys Asn Pro Glu Leu Val Ala 
65                  70                  75                  80  
Trp Asp Arg Lys Arg Asp Ser Val Leu Asn Pro Glu Glu Gln Gly Lys 
                85                  90                  95      
Phe Phe Gln Gly Asp Ile Val Leu Tyr Pro Glu Gln Ala Lys Ala Leu 
            100                 105                 110         
Tyr Glu Gln Ala Leu Thr Glu Gly Lys Thr Arg Val Lys Arg Lys Phe 
        115                 120                 125             
Ile Gly Ser Asn Leu Arg Arg Trp Asp Ala Ser Arg Pro Ile Ile Tyr 
    130                 135                 140                 
Ala Phe Asp Gly Ser His Thr Gln Arg Glu Gln Arg Ile Ile Glu Leu 
145                 150                 155                 160 
Ala Leu Glu His Trp His Asn Ile Thr Cys Leu Asn Phe Gln Arg Asn 
                165                 170                 175     
Asp Gln Ala Asn Ser Gly Asn Arg Ile Val Phe Thr Asp Val Asp Gly 
            180                 185                 190         
Cys Ala Ser Asn Val Gly Arg His Pro Leu Gly Glu Glu Gln Leu Val 
        195                 200                 205             
Ser Leu Ala Pro Glu Cys Ile Arg Leu Gly Val Ile Ala His Glu Val 
    210                 215                 220                 
Ala His Ala Leu Gly Phe Trp His Glu Gln Ser Arg Pro Asp Arg Asp 
225                 230                 235                 240 
Gln Tyr Val Thr Val Arg Trp Glu Asn Ile Asp Lys Asp Ser Lys Gly 
                245                 250                 255     
Gln Phe Leu Lys Glu Asp Pro Asp Asp Val Asp Asn Ala Gly Val Pro 
            260                 265                 270         
Tyr Asp Tyr Gly Ser Ile Met His Tyr Arg Ser Lys Ala Phe Ser Lys 
        275                 280                 285             
Phe Asp Asp Leu Tyr Thr Ile Ser Thr Tyr Val Thr Asp Tyr Gln Lys 
    290                 295                 300                 
Thr Ile Gly Gln Arg Asp Gln Leu Ser Phe Asn Asp Ile Arg Leu Met 
305                 310                 315                 320 
Asn Lys Ile Tyr Cys Ser Ala Val Cys Pro Ser Lys Leu Pro Cys Gln 
                325                 330                 335     
Arg Gly Gly Tyr Thr Asp Pro Arg Arg Cys Asp Arg Cys Arg Cys Pro 
            340                 345                 350         
Asp Gly Phe Thr Gly Gln Tyr Cys Glu Gln Val Met Pro Gly Tyr Gly 
        355                 360                 365             
Ala Thr Cys Gly Gly Lys Ile Ser Leu Thr Arg Ser Thr Thr Arg Ile 
    370                 375                 380                 
Ser Ser Pro Gly Tyr Pro Arg Glu Phe Lys Glu Gly Gln Glu Cys Ser 
385                 390                 395                 400 
Trp Leu Leu Val Ala Pro Pro Gly His Ile Val Glu Phe Gln Phe Ile 
                405                 410                 415     
Gly Glu Phe Glu Met Tyr Cys Lys Ile Arg His Ser Leu Cys Met Asp 
            420                 425                 430         
Tyr Val Glu Val Arg Asn Ser Thr Asp Phe Ala Asn Thr Gly Met Arg 
        435                 440                 445             
Tyr Cys Cys Tyr Gly Thr Pro Pro Thr Arg Ile Arg Ser Ala Thr Thr 
    450                 455                 460                 
Asp Met Val Val Leu Phe Arg Ser Phe Tyr Arg Gly Gly Lys Gly Phe 
465                 470                 475                 480 
Glu Ala Arg Ala Arg Ala Val Pro Glu Ala Gly Asn Trp Asn Ser Trp 
                485                 490                 495     
Ser Pro Trp Thr Ala Cys Ser Ala Thr Cys Gly Ala Cys Gly Ser Arg 
            500                 505                 510         
Met Arg Thr Arg Thr Cys Pro Pro Gly Asn Ala Cys Ser Gly Glu Pro 
        515                 520                 525             
Val Glu Thr Gln Ile Cys Asn Thr Gln Ala Cys Thr Gly Met Cys Ala 
    530                 535                 540                 
Gln Lys Arg Glu Glu Glu Gly Gln Cys Gly Gly Phe Leu Ser Leu Leu 
545                 550                 555                 560 
Arg Gly Val Arg Cys Arg Gln Glu Lys Thr Val Met Ala Pro Cys Glu 
                565                 570                 575     
Asn Ala Cys Cys Pro Gly Phe Thr Leu Gln Arg Gly Arg Cys Val Arg 
            580                 585                 590         



<210> 9
<211> 614
<212> PRT
<213> Teladorsagia circumcincta


<220> 
<223> DPY31_T.circumcincta

<400> 9
Met Ser Leu Leu Arg Cys Thr Thr Leu Leu Leu Val Val Val Ala Ile 
1               5                   10                  15      
Ala Leu Pro Pro Cys Ile Leu Gly Tyr Ser Leu His Asp Gly Ser Arg 
            20                  25                  30          
Leu Asp Asp Phe Leu Thr Glu Ser Ala Ala Asp Arg Arg Pro Arg Arg 
        35                  40                  45              
Pro Thr Thr Ala Ala Gln Arg Arg Leu Met Gly Leu Thr Glu Glu Gln 
    50                  55                  60                  
Tyr Lys Thr Val His Phe Tyr Leu Asn Lys Leu Lys Glu Leu Gly Asn 
65                  70                  75                  80  
Gln Arg His Pro Glu Gly Tyr Asp Lys Asp Thr Thr Lys Asp Glu Ala 
                85                  90                  95      
Asp Lys Trp Arg Lys Arg Met Arg Asp Asp Ile Glu Gly Glu Leu Leu 
            100                 105                 110         
Asn Pro Glu Glu Tyr Gly Arg His Phe Glu Gly Asp Ile Ile Leu Phe 
        115                 120                 125             
Pro Glu Gln Ala Lys Gln Ile Tyr Glu Asn Ala Leu Lys Thr Gly Gln 
    130                 135                 140                 
Arg Arg Val Lys Arg Lys Phe Ile Gly Ser Asp Leu Arg Arg Trp Asp 
145                 150                 155                 160 
Pro Thr Arg Pro Ile Val Tyr Ser Phe Asp Gly Ser His Thr Ser Arg 
                165                 170                 175     
Glu Gln Arg Ile Ile Glu Leu Ala Leu Glu His Trp His Asn Ile Thr 
            180                 185                 190         
Cys Leu Asn Phe Val Arg Asn Asp Asn Ala Asn Ser Gly Asn Arg Ile 
        195                 200                 205             
Val Phe Thr Asp Val Asp Gly Cys Ala Ser Asn Val Gly Arg His Pro 
    210                 215                 220                 
Leu Gly Glu Glu Gln Leu Val Ser Leu Ala Pro Glu Cys Ile Arg Leu 
225                 230                 235                 240 
Gly Val Ile Ala His Glu Val Ala His Ala Leu Gly Phe Trp His Glu 
                245                 250                 255     
Gln Ser Arg Pro Asp Arg Asp Gln Phe Val Asn Val Arg Trp Glu Asn 
            260                 265                 270         
Ile Asp Lys Asp Ser Lys Gly Gln Phe Leu Lys Glu Asp Pro Asp Asp 
        275                 280                 285             
Val Asp Asn Ala Gly Val Pro Tyr Asp Tyr Gly Ser Ile Met His Tyr 
    290                 295                 300                 
Arg Ser Lys Ala Phe Ser Arg Tyr Asp Asp Leu Tyr Thr Ile Ser Thr 
305                 310                 315                 320 
Phe Val Thr Asp Tyr Gln Lys Thr Ile Gly Gln Arg Asp Gln Leu Ser 
                325                 330                 335     
Phe Asn Asp Ile Arg Leu Met Asn Lys Ile Tyr Cys Ser Asn Val Cys 
            340                 345                 350         
Ser Arg Lys Leu Pro Cys Gln Arg Gly Gly Tyr Thr Asp Pro Arg Arg 
        355                 360                 365             
Cys Asp Arg Cys Arg Cys Pro Asp Gly Phe Thr Gly Gln Phe Cys Glu 
    370                 375                 380                 
Gln Val Met Pro Gly Tyr Gly Ala Val Cys Gly Gly Arg Ile Gln Val 
385                 390                 395                 400 
Asn Gly Gly Trp Thr Lys Phe Ser Ser Pro Gly Tyr Pro Arg Glu Phe 
                405                 410                 415     
Lys Glu Gly Gln Glu Cys Ser Trp Leu Leu Val Ala Pro His Gly Gln 
            420                 425                 430         
Val Val Glu Met Gln Phe Ile Gly Glu Phe Glu Met Tyr Cys Lys Val 
        435                 440                 445             
Arg His Ser Leu Cys Met Asp Tyr Val Glu Val Arg Asn Ser Thr Asp 
    450                 455                 460                 
Phe Ala Asn Thr Gly Met Arg Tyr Cys Cys Tyr Gly Thr Pro Ser Thr 
465                 470                 475                 480 
Ser Ile Arg Ser Ala Thr Thr Asp Leu Val Val Leu Phe Arg Ser Phe 
                485                 490                 495     
Tyr Arg Gly Gly Arg Gly Phe Glu Ala Arg Ala Arg Ala Leu Pro Ala 
            500                 505                 510         
Asn Gly Gln Trp Ala Ser Trp Ser Pro Trp Thr Pro Cys Thr Ala Ser 
        515                 520                 525             
Cys Gly Ala Cys Gly Ser Arg Met Arg Thr Arg Val Cys Ser His Gly 
    530                 535                 540                 
Ala Cys Ala Gly Glu Pro Val Glu Asn Gln Val Cys Asn Thr His Pro 
545                 550                 555                 560 
Cys Asn Gly Leu Cys Ala His Lys Lys Thr Glu Asp Gly Glu Cys Gly 
                565                 570                 575     
Gly Phe Leu Ala Leu Leu Arg Gly Val Arg Cys Lys Gln Glu Arg Thr 
            580                 585                 590         
Val Met Glu Pro Cys Glu Asn Ala Cys Cys Pro Gly Phe Ser Val Val 
        595                 600                 605             
Gly Gly Arg Cys Val Arg 
    610                 

<210> 10
<211> 548
<212> PRT
<213> Haemonchus contortus


<220> 
<223> DPY31_H.contortus

<400> 10
Met Ser Leu Leu Arg Ser Ala Ser Leu Leu Leu Val Val Val Thr Ala 
1               5                   10                  15      
Ala Leu Pro Pro Cys Thr Leu Gly Tyr Ser Leu His Asp Gly Ser Arg 
            20                  25                  30          
Leu Asp Asp Val Ile Ala Glu Phe Thr Ala Glu Arg Arg Pro Arg Arg 
        35                  40                  45              
Leu Ala Thr Pro Ala Gln Arg Arg Leu Met Gly Leu Thr Glu Glu Gln 
    50                  55                  60                  
His Lys Thr Val Gln Phe Tyr Leu Asp Lys Leu Arg Glu Leu Gly Asn 
65                  70                  75                  80  
Arg Arg His Pro Glu Ser Tyr Asn Lys Asp Ser Pro Lys Asn Glu Ala 
                85                  90                  95      
Tyr Lys Trp Arg Lys Gln Met Arg Asp Asp Leu Lys Thr Glu Leu Leu 
            100                 105                 110         
Asn Pro Glu Lys Tyr Gly Arg His Phe Glu Gly Asp Ile Ile Leu Phe 
        115                 120                 125             
Pro Glu Gln Ala Lys Gln Ile Tyr Glu Asn Ala Leu Lys Thr Gly Gln 
    130                 135                 140                 
Arg Arg Val Lys Arg Lys Phe Ile Gly Ser Asp Leu Arg Arg Trp Asp 
145                 150                 155                 160 
Pro Thr Arg Pro Ile Ile Tyr Ser Phe Asp Gly Ser His Thr Ser Arg 
                165                 170                 175     
Glu Gln Arg Ile Ile Glu Leu Ala Leu Glu His Arg His Asn Ile Thr 
            180                 185                 190         
Cys Leu Asn Phe Val Arg Asn Asp Asn Ala Asn Lys Gly Asn Arg Ile 
        195                 200                 205             
Val Phe Thr Asp Val Asp Gly Cys Ala Ser Asn Val Gly Arg His Pro 
    210                 215                 220                 
Leu Gly Glu Glu Gln Leu Val Ser Leu Ala Pro Glu Cys Ile Arg Leu 
225                 230                 235                 240 
Gly Val Ile Ala His Glu Val Ala His Ala Leu Gly Phe Trp His Glu 
                245                 250                 255     
Gln Ser Arg Pro Asp Arg Asp Gln Phe Val Asn Val Arg Trp Glu Asn 
            260                 265                 270         
Ile Asp Lys Asp Ser Lys Gly Gln Phe Leu Lys Glu Asp Pro Asp Asp 
        275                 280                 285             
Val Asp Asn Ala Gly Val Pro Tyr Asp Tyr Gly Ser Ile Met His Tyr 
    290                 295                 300                 
Arg Ser Lys Ala Phe Ser Arg Tyr Asp Asp Leu Tyr Thr Ile Ser Thr 
305                 310                 315                 320 
Phe Val Thr Asp Tyr Gln Lys Thr Ile Gly Gln Arg Asp Gln Leu Ser 
                325                 330                 335     
Phe Asn Asp Ile Arg Leu Met Asn Lys Ile Tyr Cys Ser Asn Val Cys 
            340                 345                 350         
Ser Arg Lys Leu Pro Cys Gln Arg Gly Gly Tyr Thr Asp Pro Arg Arg 
        355                 360                 365             
Cys Asp Arg Cys Arg Cys Pro Asp Gly Phe Thr Gly Gln Phe Cys Glu 
    370                 375                 380                 
Gln Val Met Pro Gly Tyr Gly Ala Val Cys Gly Gly Arg Ile Gln Val 
385                 390                 395                 400 
Asn Ser Gly Trp Thr Arg Phe Ser Ser Pro Gly Tyr Pro Arg Glu Phe 
                405                 410                 415     
Lys Glu Gly Gln Glu Cys Ser Trp Leu Leu Val Ala Pro Pro Gly Gln 
            420                 425                 430         
Val Val Glu Met Gln Phe Ile Gly Glu Phe Glu Met Tyr Cys Lys Val 
        435                 440                 445             
Arg His Ser Leu Cys Met Asp Tyr Val Glu Val Arg Asn Ser Thr Asp 
    450                 455                 460                 
Phe Ala Asn Thr Gly Met Arg Tyr Cys Cys Tyr Gly Thr Pro Ser Thr 
465                 470                 475                 480 
Ser Ile Arg Ser Ala Thr Thr Asp Leu Val Val Leu Phe Arg Ser Phe 
                485                 490                 495     
Tyr Arg Gly Gly Arg Gly Phe Glu Ala Arg Ala Arg Ala Leu Pro Ala 
            500                 505                 510         
Asn Gly Gln Trp Ala Ser Trp Thr Pro Trp Thr Pro Cys Thr Ala Ser 
        515                 520                 525             
Cys Gly Ala Cys Gly Ser Arg Met Arg Thr Arg Val Cys Pro His Gly 
    530                 535                 540                 
Ala Cys Pro Cys 
545             

