                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  HUMAN ANTIBODIES TO BONE MORPHOGENETIC PROTEIN 6

<130>  0431.31PCT

<150>  62860597
<151>  2019-06-12

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Pro Tyr Asn Ser Pro Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  2
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Val Val Tyr Tyr Cys Gln His Phe Gly Gly Thr Pro 
                85                  90                  95      


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Arg Ser Ser Pro Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Phe Tyr Ser Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ile Ser Gly Ser Gly Gly Arg Thr 
1               5               


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Ala Lys Arg Pro Tyr Asn Ser Pro Phe Asp Pro 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  9
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gly Ala Ser 
1           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Gln His Phe Gly Gly Thr Pro Phe Thr 
1               5                   


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gly Phe Thr Phe Asn Asn Tyr Ala 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Ile Ser Gly Ser Gly Asp Ser Thr 
1               5               


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Ala Lys Arg Ser Arg Ser Ser Pro Phe Asp Pro 
1               5                   10      


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Lys Ala Ser 
1           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Gln Gln Tyr Asn Phe Tyr Ser Trp Thr 
1               5                   


<210>  17
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacgttcagt agctatgcca tgagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctccgct attagtggca gtggtggtag aacatactat      180

acagactccg tgaagggccg gttcaccatg tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaagcgcccc      300

tataatagcc cgttcgaccc ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  18
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
gaaatagtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aggagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgtagtgta ttactgccag cactttggtg gcacaccgtt cactttcggc      300

ggagggacca aggtggagat caaa                                             324


<210>  19
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaac aactatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtgatag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaaggagt      300

aggtcgtccc cgttcgaccc ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  20
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataattttt attcgtggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
ggattcacgt tcagtagcta tgcc                                              24


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
attagtggca gtggtggtag aaca                                              24


<210>  23
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
gcgaagcgcc cctataatag cccgttcgac ccc                                    33


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
cagagtgtta gcagcagcta c                                                 21


<210>  25
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
ggtgcatcc                                                                9


<210>  26
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
cagcactttg gtggcacacc gttcact                                           27


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
ggattcacct ttaacaacta tgcc                                              24


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
attagtggta gtggtgatag caca                                              24


<210>  29
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gcgaaaagga gtaggtcgtc cccgttcgac ccc                                    33


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
cagagtatta gtagctgg                                                     18


<210>  31
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
aaggcgtct                                                                9


<210>  32
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
caacagtata atttttattc gtggacg                                           27


<210>  33
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Pro Tyr Asn Ser Pro Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  34
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Gly Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Val Val Tyr Tyr Cys Gln His Phe Gly Gly Thr Pro 
                85                  90                  95      


Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  35
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ser Arg Ser Ser Pro Phe Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  36
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Phe Tyr Ser Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  37
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser Ser Thr Leu 
1               5                   10                  15      


Ser Leu Arg Gly Gly Gly Ser Ser Gly Ala Leu Arg Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Arg Gly Gly Gly Val Gly Ser Gly Gly Leu Cys Arg Ala Leu 
        35                  40                  45              


Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly 
    50                  55                  60                  


Asp Leu Ala Phe His Ser Ala Val His Gly Ile Glu Asp Leu Met Ile 
65                  70                  75                  80  


Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro Pro Pro Arg 
                85                  90                  95      


Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala Pro Asp Pro 
            100                 105                 110         


Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg Pro Pro Gly 
        115                 120                 125             


Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg Ser Phe His 
    130                 135                 140                 


His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu Leu Asp 
145                 150                 155                 160 


Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala Leu Gly 
                165                 170                 175     


Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys Asn Met 
            180                 185                 190         


Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn Leu 
        195                 200                 205             


Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro Gly 
    210                 215                 220                 


Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val Glu 
225                 230                 235                 240 


Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr Ala 
                245                 250                 255     


Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala Met Ala 
            260                 265                 270         


Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys Pro Pro 
        275                 280                 285             


Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala Ile Thr 
    290                 295                 300                 


Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val Glu Asp 
305                 310                 315                 320 


Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly Asp Pro 
                325                 330                 335     


Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg Ala Phe 
            340                 345                 350         


Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Gly Pro Gly Asp 
        355                 360                 365             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    370                 375                 380                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
385                 390                 395                 400 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                405                 410                 415     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            420                 425                 430         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        435                 440                 445             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    450                 455                 460                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
465                 470                 475                 480 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                485                 490                 495     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            500                 505                 510         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        515                 520                 525             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    530                 535                 540                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
545                 550                 555                 560 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                565                 570                 575     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            580                 585                 590         


Gly Lys 
        


<210>  38
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Ser Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp 
1               5                   10                  15      


Arg Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys 
            20                  25                  30          


Arg Arg His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu 
        35                  40                  45              


Ile Val Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg 
    50                  55                  60                  


Thr Asp Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys 
65                  70                  75                  80  


Cys Glu Gly Asn Met Cys Asn Glu Lys Phe Ser Tyr Phe Pro Glu Met 
                85                  90                  95      


Glu Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro Asp Lys 
            100                 105                 110         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        115                 120                 125             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    130                 135                 140                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
145                 150                 155                 160 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                165                 170                 175     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            180                 185                 190         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        195                 200                 205             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    210                 215                 220                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
225                 230                 235                 240 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                245                 250                 255     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            260                 265                 270         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        275                 280                 285             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    290                 295                 300                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
305                 310                 315                 320 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 330                 335     


Lys 
    


<210>  39
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Glu Ala Glu Thr Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu 
1               5                   10                  15      


Glu Arg Thr Asn Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp 
            20                  25                  30          


Lys Arg Leu His Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile 
        35                  40                  45              


Glu Leu Val Lys Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp 
    50                  55                  60                  


Arg Gln Glu Cys Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys 
65                  70                  75                  80  


Cys Cys Glu Gly Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro Glu 
                85                  90                  95      


Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro Ser 
            100                 105                 110         


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        115                 120                 125             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    130                 135                 140                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
145                 150                 155                 160 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                165                 170                 175     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            180                 185                 190         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        195                 200                 205             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    210                 215                 220                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
225                 230                 235                 240 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                245                 250                 255     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            260                 265                 270         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        275                 280                 285             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    290                 295                 300                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
305                 310                 315                 320 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                325                 330                 335     


Ser Pro Gly Lys 
            340 


<210>  40
<211>  513
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CARBOHYD
<222>  (241)..(241)
<223>  N-linked glycosylation

<220>
<221>  CARBOHYD
<222>  (269)..(269)
<223>  N-linked glycosylation

<220>
<221>  CARBOHYD
<222>  (386)..(386)
<223>  N-linked glycosylation

<220>
<221>  CARBOHYD
<222>  (404)..(404)
<223>  N-linked glycosylation

<220>
<221>  DISULFID
<222>  (412)..(478)

<220>
<221>  DISULFID
<222>  (441)..(510)

<220>
<221>  DISULFID
<222>  (445)..(512)

<220>
<221>  CARBOHYD
<222>  (454)..(454)
<223>  N-linked glycosylation

<220>
<221>  DISULFID
<222>  (477)..(477)

<220>
<221>  DISULFID
<222>  (477)..(477)
<223>  interchain

<400>  40

Met Pro Gly Leu Gly Arg Arg Ala Gln Trp Leu Cys Trp Trp Trp Gly 
1               5                   10                  15      


Leu Leu Cys Ser Cys Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Leu Leu Gly Asp Gly Gly 
        35                  40                  45              


Ser Pro Gly Arg Thr Glu Gln Pro Pro Pro Ser Pro Gln Ser Ser Ser 
    50                  55                  60                  


Gly Phe Leu Tyr Arg Arg Leu Lys Thr Gln Glu Lys Arg Glu Met Gln 
65                  70                  75                  80  


Lys Glu Ile Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu 
                85                  90                  95      


His Gly Leu Gln Gln Pro Gln Pro Pro Ala Leu Arg Gln Gln Glu Glu 
            100                 105                 110         


Gln Gln Gln Gln Gln Gln Leu Pro Arg Gly Glu Pro Pro Pro Gly Arg 
        115                 120                 125             


Leu Lys Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser 
    130                 135                 140                 


Ala Asp Asn Asp Glu Asp Gly Ala Ser Glu Gly Glu Arg Gln Gln Ser 
145                 150                 155                 160 


Trp Pro His Glu Ala Ala Ser Ser Ser Gln Arg Arg Gln Pro Pro Pro 
                165                 170                 175     


Gly Ala Ala His Pro Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Ser 
            180                 185                 190         


Gly Ser Gly Gly Ala Ser Pro Leu Thr Ser Ala Gln Asp Ser Ala Phe 
        195                 200                 205             


Leu Asn Asp Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr 
    210                 215                 220                 


Asp Lys Glu Phe Ser Pro Arg Gln Arg His His Lys Glu Phe Lys Phe 
225                 230                 235                 240 


Asn Leu Ser Gln Ile Pro Glu Gly Glu Val Val Thr Ala Ala Glu Phe 
                245                 250                 255     


Arg Ile Tyr Lys Asp Cys Val Met Gly Ser Phe Lys Asn Gln Thr Phe 
            260                 265                 270         


Leu Ile Ser Ile Tyr Gln Val Leu Gln Glu His Gln His Arg Asp Ser 
        275                 280                 285             


Asp Leu Phe Leu Leu Asp Thr Arg Val Val Trp Ala Ser Glu Glu Gly 
    290                 295                 300                 


Trp Leu Glu Phe Asp Ile Thr Ala Thr Ser Asn Leu Trp Val Val Thr 
305                 310                 315                 320 


Pro Gln His Asn Met Gly Leu Gln Leu Ser Val Val Thr Arg Asp Gly 
                325                 330                 335     


Val His Val His Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro 
            340                 345                 350         


Tyr Asp Lys Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val 
        355                 360                 365             


His Val Arg Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser 
    370                 375                 380                 


Arg Asn Arg Ser Thr Gln Ser Gln Asp Val Ala Arg Val Ser Ser Ala 
385                 390                 395                 400 


Ser Asp Tyr Asn Ser Ser Glu Leu Lys Thr Ala Cys Arg Lys His Glu 
                405                 410                 415     


Leu Tyr Val Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala 
            420                 425                 430         


Pro Lys Gly Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro 
        435                 440                 445             


Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu 
    450                 455                 460                 


Val His Leu Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro 
465                 470                 475                 480 


Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn 
                485                 490                 495     


Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys 
            500                 505                 510         


His 
    


<210>  41
<211>  10
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  n is a, c, g, or t

<400>  41
nnnnnnnnnn                                                              10


<210>  42
<211>  510
<212>  PRT
<213>  Mus musculus


<220>
<221>  CARBOHYD
<222>  (238)..(238)
<223>  N-linked glycosylation

<220>
<221>  CARBOHYD
<222>  (266)..(266)
<223>  N-linked glycosylation

<220>
<221>  CARBOHYD
<222>  (383)..(383)
<223>  N-linked glycosylation

<220>
<221>  CARBOHYD
<222>  (401)..(401)
<223>  N-linked glycosylation

<220>
<221>  DISULFID
<222>  (409)..(475)

<220>
<221>  DISULFID
<222>  (438)..(507)

<220>
<221>  DISULFID
<222>  (442)..(509)

<220>
<221>  CARBOHYD
<222>  (451)..(451)
<223>  N-linked glycosylation

<220>
<221>  DISULFID
<222>  (474)..(474)
<223>  Interchain

<400>  42

Met Pro Gly Leu Gly Arg Arg Ala Gln Trp Leu Cys Trp Trp Trp Gly 
1               5                   10                  15      


Leu Leu Cys Ser Cys Gly Pro Pro Pro Leu Arg Pro Pro Leu Pro Val 
            20                  25                  30          


Ala Ala Ala Ala Ala Gly Gly Gln Leu Leu Gly Ala Gly Gly Ser Pro 
        35                  40                  45              


Val Arg Ala Glu Gln Pro Pro Pro Gln Ser Ser Ser Ser Gly Phe Leu 
    50                  55                  60                  


Tyr Arg Arg Leu Lys Thr His Glu Lys Arg Glu Met Gln Lys Glu Ile 
65                  70                  75                  80  


Leu Ser Val Leu Gly Leu Pro His Arg Pro Arg Pro Leu His Gly Leu 
                85                  90                  95      


Gln Gln Pro Gln Pro Pro Val Leu Pro Pro Gln Gln Gln Gln Gln Gln 
            100                 105                 110         


Gln Gln Gln Gln Thr Ala Arg Glu Glu Pro Pro Pro Gly Arg Leu Lys 
        115                 120                 125             


Ser Ala Pro Leu Phe Met Leu Asp Leu Tyr Asn Ala Leu Ser Asn Asp 
    130                 135                 140                 


Asp Glu Glu Asp Gly Ala Ser Glu Gly Val Gly Gln Glu Pro Gly Ser 
145                 150                 155                 160 


His Gly Gly Ala Ser Ser Ser Gln Leu Arg Gln Pro Ser Pro Gly Ala 
                165                 170                 175     


Ala His Ser Leu Asn Arg Lys Ser Leu Leu Ala Pro Gly Pro Gly Gly 
            180                 185                 190         


Gly Ala Ser Pro Leu Thr Ser Ala Gln Asp Ser Ala Phe Leu Asn Asp 
        195                 200                 205             


Ala Asp Met Val Met Ser Phe Val Asn Leu Val Glu Tyr Asp Lys Glu 
    210                 215                 220                 


Phe Ser Pro His Gln Arg His His Lys Glu Phe Lys Phe Asn Leu Ser 
225                 230                 235                 240 


Gln Ile Pro Glu Gly Glu Ala Val Thr Ala Ala Glu Phe Arg Val Tyr 
                245                 250                 255     


Lys Asp Cys Val Val Gly Ser Phe Lys Asn Gln Thr Phe Leu Ile Ser 
            260                 265                 270         


Ile Tyr Gln Val Leu Gln Glu His Gln His Arg Asp Ser Asp Leu Phe 
        275                 280                 285             


Leu Leu Asp Thr Arg Val Val Trp Ala Ser Glu Glu Gly Trp Leu Glu 
    290                 295                 300                 


Phe Asp Ile Thr Ala Thr Ser Asn Leu Trp Val Val Thr Pro Gln His 
305                 310                 315                 320 


Asn Met Gly Leu Gln Leu Ser Val Val Thr Arg Asp Gly Leu His Val 
                325                 330                 335     


Asn Pro Arg Ala Ala Gly Leu Val Gly Arg Asp Gly Pro Tyr Asp Lys 
            340                 345                 350         


Gln Pro Phe Met Val Ala Phe Phe Lys Val Ser Glu Val His Val Arg 
        355                 360                 365             


Thr Thr Arg Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser Arg Asn Arg 
    370                 375                 380                 


Ser Thr Gln Ser Gln Asp Val Ser Arg Gly Ser Gly Ser Ser Asp Tyr 
385                 390                 395                 400 


Asn Gly Ser Glu Leu Lys Thr Ala Cys Lys Lys His Glu Leu Tyr Val 
                405                 410                 415     


Ser Phe Gln Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Lys Gly 
            420                 425                 430         


Tyr Ala Ala Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro Leu Asn Ala 
        435                 440                 445             


His Met Asn Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Leu 
    450                 455                 460                 


Met Asn Pro Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro Thr Lys Leu 
465                 470                 475                 480 


Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn Val Ile Leu 
                485                 490                 495     


Lys Lys Tyr Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
            500                 505                 510 


<210>  43
<211>  10
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  n is a, c, g, or t

<400>  43
nnnnnnnnnn                                                              10


