                         SEQUENCE LISTING
<110>  Ascendis Pharma A/S
 
<120>  Anti-CTLA4 compounds with localized PK properties
<130>  CP72477PC
<160>  3     
<170>  PatentIn version 3.5
<210>  1
<211>  132
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  aldesleukin mutein
<400>  1
Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
1               5                   10                  15      
Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            20                  25                  30          
Pro Lys Leu Thr Cys Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        35                  40                  45              
Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  
Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
65                  70                  75                  80  
Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                85                  90                  95      
Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         
Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile Ile 
        115                 120                 125             
Ser Thr Leu Thr 
    130         
<210>  2
<211>  247
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  nanobody
<400>  2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          
Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              
Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
        115                 120                 125             
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
    130                 135                 140                 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
145                 150                 155                 160 
Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
                165                 170                 175     
Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
            180                 185                 190         
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
        195                 200                 205             
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 
Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 
Thr Gln Val Thr Val Ser Ser 
                245         
<210>  3
<211>  133
<212>  PRT
<213>  Artificial Sequence
<220>
<223>  aldesleukin mutein
<400>  3
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      
Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          
Asn Pro Lys Leu Thr Cys Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              
Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  
Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  
Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      
Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         
Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             
Ile Ser Thr Leu Thr 
    130             
