                         SEQUENCE LISTING

<110>  CEDARS-SINAI MEDICAL CENTER
       BREUNIG, Joshua
       DANIELPOUR, Moise
       KIM, Gi Bum
       AYALA-SARMIENTO, Alberto
       YANG, Amy
 
<120>  SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED 
       CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF

<130>  065472-000508WO10

<150>  62/862,576
<151>  2019-06-17

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1
atgaagttat gggatgtcgt ggctgtctgc ctggtgctgc tccacaccgc gtccgccttc       60

ccgctgcccg ccggtaagag gcctcccgag gcgcccgccg aagaccgctc cctcggccgc      120

cgccgcgcgc ccttcgcgct gagcagtgac tcaaatatgc cagaggatta tcctgatcag      180

ttcgatgatg tcatggattt tattcaagcc accattaaaa gactgaaaag gtcaccagat      240

aaacaaatgg cagtgcttcc tagaagagag cggaatcggc aggctgcagc tgccaaccca      300

gagaattcca gaggaaaagg tcggagaggc cagaggggca aaaaccgggg ttgtgtctta      360

actgcaatac atttaaatgt cactgacttg ggtctgggct atgaaaccaa ggaggaactg      420

atttttaggt actgcagcgg ctcttgcgat gcagctgaga caacgtacga caaaatattg      480

aaaaacttat ccagaaatag aaggctggtg agtgacaaag tagggcaggc atgttgcaga      540

cccatcgcct ttgatgatga cctgtcgttt ttagatgata acctggttta ccatattcta      600

agaaagcatt ccgctaaaag gtgtggatgt atctga                                636


<210>  2
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


<210>  3
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3
aactccctcg atgtggcggc tcatctgccc                                        30


<210>  4
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4
aactccctcg aatgtggcgg ctcatctgcc c                                      31


<210>  5
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5
tctcctggct cagagggagc tcgaggctg                                         29


<210>  6
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (5)..(11)
<223>  n is a, c, t, g or can be none

<400>  6
tctcnnnnnn nagagggagc tcgaggctg                                         29


<210>  7
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7
ctggttcctc agtcacacat gccagagg                                          28


<210>  8
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8
cctctgagcc aggagacatt ttcagg                                            26


<210>  9
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  9
ttccctcagc cattgcctgt gtgtgg                                            26


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  10

Leu Val Pro Gln Ser His Met Pro Glu Val 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid, or none

<400>  11

Leu Val Pro Xaa Ser His Met Pro Glu Val 
1               5                   10  


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  12

Pro Leu Ser Gln Glu Thr Phe Ser Gly 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid, or none

<400>  13

Pro Leu Ser Xaa Glu Thr Phe Ser Gly 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Phe Pro Gln Pro Leu Pro Val Cys Gly 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid, or none

<400>  15

Phe Pro Xaa Pro Leu Pro Val Cys Gly 
1               5                   


<210>  16
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  16
ataacttcgt atagcataca ttatacgaag ttat                                   34


<210>  17
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  17
ataacttcgt ataatgtatg ctatacgaag ttat                                   34


<210>  18
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  18
gaagttccta ttctctagaa agtataggaa cttc                                   34


<210>  19
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  19
gaagttccta tactttctag agaataggaa cttcggaata ggaacttc                    48


<210>  20
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  20
ggatgagtca tc                                                           12


<210>  21
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21
gatgactcat                                                              10


<210>  22
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22
gatgagtcat cc                                                           12


<210>  23
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23
cctttgttcg                                                              10


<210>  24
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24
cccattgttc                                                              10


<210>  25
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25
cttggcactg tgccaa                                                       16


<210>  26
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26
gacatctggt                                                              10


<210>  27
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  27
accatctgtt                                                              10


<210>  28
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28
gcggcagctg ct                                                           12


<210>  29
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29
tatgcaaatg ag                                                           12


<210>  30
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  30
ccattgtatg caaat                                                        15


<210>  31
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  31
atttgcataa                                                              10


<210>  32
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  32
atttgcataa caatg                                                        15


<210>  33
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  33
ttgctttcca ggaaa                                                        15


<210>  34
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  34
ctgtttac                                                                 8


<210>  35
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  35
aggggatttc cc                                                           12


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  36
gcctcagcca ttgcctgtgt g                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37
gcctcgagct ccctctgagc c                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38
gcagatgagc cgccacatcg a                                                 21


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39
cctcagccat tgcctgtgtg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  40
ctgagccagg agacattttc                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  41
tcctcagtca cacatgccag                                                   20


