                         SEQUENCE LISTING

<110>  In3Bio, Ltd
 
<120>  STABILIZED CHIMERIC SYNTHETIC PROTEINS AND THERAPEUTIC USES 
       THEREOF

<130>  48199-106WO

<140>  PCT/IB2020/000538
<141>  2020-06-24

<150>  US 62/866,190
<151>  2019-06-25

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1

Ser Ser Gly 
1           


<210>  2
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2

Ser Gly Gly 
1           


<210>  3
<211>  12729
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  3
gtccgggcag cccccggcgc agcgcggccg cagcagcctc cgccccccgc acggtgtgag       60

cgcccgacgc ggccgaggcg gccggagtcc cgagctagcc ccggcggccg ccgccgccca      120

gaccggacga caggccacct cgtcggcgtc cgcccgagtc cccgcctcgc cgccaacgcc      180

acaaccaccg cgcacggccc cctgactccg tccagtattg atcgggagag ccggagcgag      240

ctcttcgggg agcagcgatg cgaccctccg ggacggccgg ggcagcgctc ctggcgctgc      300

tggctgcgct ctgcccggcg agtcgggctc tggaggaaaa gaaagtttgc caaggcacga      360

gtaacaagct cacgcagttg ggcacttttg aagatcattt tctcagcctc cagaggatgt      420

tcaataactg tgaggtggtc cttgggaatt tggaaattac ctatgtgcag aggaattatg      480

atctttcctt cttaaagacc atccaggagg tggctggtta tgtcctcatt gccctcaaca      540

cagtggagcg aattcctttg gaaaacctgc agatcatcag aggaaatatg tactacgaaa      600

attcctatgc cttagcagtc ttatctaact atgatgcaaa taaaaccgga ctgaaggagc      660

tgcccatgag aaatttacag gaaatcctgc atggcgccgt gcggttcagc aacaaccctg      720

ccctgtgcaa cgtggagagc atccagtggc gggacatagt cagcagtgac tttctcagca      780

acatgtcgat ggacttccag aaccacctgg gcagctgcca aaagtgtgat ccaagctgtc      840

ccaatgggag ctgctggggt gcaggagagg agaactgcca gaaactgacc aaaatcatct      900

gtgcccagca gtgctccggg cgctgccgtg gcaagtcccc cagtgactgc tgccacaacc      960

agtgtgctgc aggctgcaca ggcccccggg agagcgactg cctggtctgc cgcaaattcc     1020

gagacgaagc cacgtgcaag gacacctgcc ccccactcat gctctacaac cccaccacgt     1080

accagatgga tgtgaacccc gagggcaaat acagctttgg tgccacctgc gtgaagaagt     1140

gtccccgtaa ttatgtggtg acagatcacg gctcgtgcgt ccgagcctgt ggggccgaca     1200

gctatgagat ggaggaagac ggcgtccgca agtgtaagaa gtgcgaaggg ccttgccgca     1260

aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata aatgctacga     1320

atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc ctgccggtgg     1380

catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa ctggatattc     1440

tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct gaaaacagga     1500

cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag caacatggtc     1560

agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc tccctcaagg     1620

agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat gcaaatacaa     1680

taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata agcaacagag     1740

gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc cccgagggct     1800

gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga ggcagggaat     1860

gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag aactctgagt     1920

gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc acaggacggg     1980

gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc gtcaagacct     2040

gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca gacgccggcc     2100

atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca ggtcttgaag     2160

gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg ggggccctcc     2220

tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gcgaaggcgc cacatcgttc     2280

ggaagcgcac gctgcggagg ctgctgcagg agagggagct tgtggagcct cttacaccca     2340

gtggagaagc tcccaaccaa gctctcttga ggatcttgaa ggaaactgaa ttcaaaaaga     2400

tcaaagtgct gggctccggt gcgttcggca cggtgtataa gggactctgg atcccagaag     2460

gtgagaaagt taaaattccc gtcgctatca aggaattaag agaagcaaca tctccgaaag     2520

ccaacaagga aatcctcgat gaagcctacg tgatggccag cgtggacaac ccccacgtgt     2580

gccgcctgct gggcatctgc ctcacctcca ccgtgcagct catcacgcag ctcatgccct     2640

tcggctgcct cctggactat gtccgggaac acaaagacaa tattggctcc cagtacctgc     2700

tcaactggtg tgtgcagatc gcaaagggca tgaactactt ggaggaccgt cgcttggtgc     2760

accgcgacct ggcagccagg aacgtactgg tgaaaacacc gcagcatgtc aagatcacag     2820

attttgggct ggccaaactg ctgggtgcgg aagagaaaga ataccatgca gaaggaggca     2880

aagtgcctat caagtggatg gcattggaat caattttaca cagaatctat acccaccaga     2940

gtgatgtctg gagctacggg gtgactgttt gggagttgat gacctttgga tccaagccat     3000

atgacggaat ccctgccagc gagatctcct ccatcctgga gaaaggagaa cgcctccctc     3060

agccacccat atgtaccatc gatgtctaca tgatcatggt caagtgctgg atgatagacg     3120

cagatagtcg cccaaagttc cgtgagttga tcatcgaatt ctccaaaatg gcccgagacc     3180

cccagcgcta ccttgtcatt cagggggatg aaagaatgca tttgccaagt cctacagact     3240

ccaacttcta ccgtgccctg atggatgaag aagacatgga cgacgtggtg gatgccgacg     3300

agtacctcat cccacagcag ggcttcttca gcagcccctc cacgtcacgg actcccctcc     3360

tgagctctct gagtgcaacc agcaacaatt ccaccgtggc ttgcattgat agaaatgggc     3420

tgcaaagctg tcccatcaag gaagacagct tcttgcagcg atacagctca gaccccacag     3480

gcgccttgac tgaggacagc atagacgaca ccttcctccc agtgcctgaa tacataaacc     3540

agtccgttcc caaaaggccc gctggctctg tgcagaatcc tgtctatcac aatcagcctc     3600

tgaaccccgc gcccagcaga gacccacact accaggaccc ccacagcact gcagtgggca     3660

accccgagta tctcaacact gtccagccca cctgtgtcaa cagcacattc gacagccctg     3720

cccactgggc ccagaaaggc agccaccaaa ttagcctgga caaccctgac taccagcagg     3780

acttctttcc caaggaagcc aagccaaatg gcatctttaa gggctccaca gctgaaaatg     3840

cagaatacct aagggtcgcg ccacaaagca gtgaatttat tggagcatga ccacggagga     3900

tagtatgagc cctaaaaatc cagactcttt cgatacccag gaccaagcca cagcaggtcc     3960

tccatcccaa cagccatgcc cgcattagct cttagaccca cagactggtt ttgcaacgtt     4020

tacaccgact agccaggaag tacttccacc tcgggcacat tttgggaagt tgcattcctt     4080

tgtcttcaaa ctgtgaagca tttacagaaa cgcatccagc aagaatattg tccctttgag     4140

cagaaattta tctttcaaag aggtatattt gaaaaaaaaa aaaagtatat gtgaggattt     4200

ttattgattg gggatcttgg agtttttcat tgtcgctatt gatttttact tcaatgggct     4260

cttccaacaa ggaagaagct tgctggtagc acttgctacc ctgagttcat ccaggcccaa     4320

ctgtgagcaa ggagcacaag ccacaagtct tccagaggat gcttgattcc agtggttctg     4380

cttcaaggct tccactgcaa aacactaaag atccaagaag gccttcatgg ccccagcagg     4440

ccggatcggt actgtatcaa gtcatggcag gtacagtagg ataagccact ctgtcccttc     4500

ctgggcaaag aagaaacgga ggggatggaa ttcttcctta gacttacttt tgtaaaaatg     4560

tccccacggt acttactccc cactgatgga ccagtggttt ccagtcatga gcgttagact     4620

gacttgtttg tcttccattc cattgttttg aaactcagta tgctgcccct gtcttgctgt     4680

catgaaatca gcaagagagg atgacacatc aaataataac tcggattcca gcccacattg     4740

gattcatcag catttggacc aatagcccac agctgagaat gtggaatacc taaggatagc     4800

accgcttttg ttctcgcaaa aacgtatctc ctaatttgag gctcagatga aatgcatcag     4860

gtcctttggg gcatagatca gaagactaca aaaatgaagc tgctctgaaa tctcctttag     4920

ccatcacccc aaccccccaa aattagtttg tgttacttat ggaagatagt tttctccttt     4980

tacttcactt caaaagcttt ttactcaaag agtatatgtt ccctccaggt cagctgcccc     5040

caaaccccct ccttacgctt tgtcacacaa aaagtgtctc tgccttgagt catctattca     5100

agcacttaca gctctggcca caacagggca ttttacaggt gcgaatgaca gtagcattat     5160

gagtagtgtg gaattcaggt agtaaatatg aaactagggt ttgaaattga taatgctttc     5220

acaacatttg cagatgtttt agaaggaaaa aagttccttc ctaaaataat ttctctacaa     5280

ttggaagatt ggaagattca gctagttagg agcccacctt ttttcctaat ctgtgtgtgc     5340

cctgtaacct gactggttaa cagcagtcct ttgtaaacag tgttttaaac tctcctagtc     5400

aatatccacc ccatccaatt tatcaaggaa gaaatggttc agaaaatatt ttcagcctac     5460

agttatgttc agtcacacac acatacaaaa tgttcctttt gcttttaaag taatttttga     5520

ctcccagatc agtcagagcc cctacagcat tgttaagaaa gtatttgatt tttgtctcaa     5580

tgaaaataaa actatattca tttccactct attatgctct caaatacccc taagcatcta     5640

tactagcctg gtatgggtat gaaagataca aagataaata aaacatagtc cctgattcta     5700

agaaattcac aatttagcaa aggaaatgga ctcatagatg ctaaccttaa aacaacgtga     5760

caaatgccag acaggaccca tcagccaggc actgtgagag cacagagcag ggaggttggg     5820

tcctgcctga ggagacctgg aagggaggcc tcacaggagg atgaccaggt ctcagtcagc     5880

ggggaggtgg aaagtgcagg tgcatcaggg gcaccctgac cgaggaaaca gctgccagag     5940

gcctccactg ctaaagtcca cataaggctg aggtcagtca ccctaaacaa cctgctccct     6000

ctaagccagg ggatgagctt ggagcatccc acaagttccc taaaagttgc agcccccagg     6060

gggattttga gctatcatct ctgcacatgc ttagtgagaa gactacacaa catttctaag     6120

aatctgagat tttatattgt cagttaacca ctttcattat tcattcacct caggacatgc     6180

agaaatattt cagtcagaac tgggaaacag aaggacctac attctgctgt cacttatgtg     6240

tcaagaagca gatgatcgat gaggcaggtc agttgtaagt gagtcacatt gtagcattaa     6300

attctagtat ttttgtagtt tgaaacagta acttaataaa agagcaaaag ctaaaaaaaa     6360

gtccgggcag cccccggcgc agcgcggccg cagcagcctc cgccccccgc acggtgtgag     6420

cgcccgacgc ggccgaggcg gccggagtcc cgagctagcc ccggcggccg ccgccgccca     6480

gaccggacga caggccacct cgtcggcgtc cgcccgagtc cccgcctcgc cgccaacgcc     6540

acaaccaccg cgcacggccc cctgactccg tccagtattg atcgggagag ccggagcgag     6600

ctcttcgggg agcagcgatg cgaccctccg ggacggccgg ggcagcgctc ctggcgctgc     6660

tggctgcgct ctgcccggcg agtcgggctc tggaggaaaa gaaagtttgc caaggcacga     6720

gtaacaagct cacgcagttg ggcacttttg aagatcattt tctcagcctc cagaggatgt     6780

tcaataactg tgaggtggtc cttgggaatt tggaaattac ctatgtgcag aggaattatg     6840

atctttcctt cttaaagacc atccaggagg tggctggtta tgtcctcatt gccctcaaca     6900

cagtggagcg aattcctttg gaaaacctgc agatcatcag aggaaatatg tactacgaaa     6960

attcctatgc cttagcagtc ttatctaact atgatgcaaa taaaaccgga ctgaaggagc     7020

tgcccatgag aaatttacag gaaatcctgc atggcgccgt gcggttcagc aacaaccctg     7080

ccctgtgcaa cgtggagagc atccagtggc gggacatagt cagcagtgac tttctcagca     7140

acatgtcgat ggacttccag aaccacctgg gcagctgcca aaagtgtgat ccaagctgtc     7200

ccaatgggag ctgctggggt gcaggagagg agaactgcca gaaactgacc aaaatcatct     7260

gtgcccagca gtgctccggg cgctgccgtg gcaagtcccc cagtgactgc tgccacaacc     7320

agtgtgctgc aggctgcaca ggcccccggg agagcgactg cctggtctgc cgcaaattcc     7380

gagacgaagc cacgtgcaag gacacctgcc ccccactcat gctctacaac cccaccacgt     7440

accagatgga tgtgaacccc gagggcaaat acagctttgg tgccacctgc gtgaagaagt     7500

gtccccgtaa ttatgtggtg acagatcacg gctcgtgcgt ccgagcctgt ggggccgaca     7560

gctatgagat ggaggaagac ggcgtccgca agtgtaagaa gtgcgaaggg ccttgccgca     7620

aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata aatgctacga     7680

atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc ctgccggtgg     7740

catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa ctggatattc     7800

tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct gaaaacagga     7860

cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag caacatggtc     7920

agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc tccctcaagg     7980

agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat gcaaatacaa     8040

taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata agcaacagag     8100

gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc cccgagggct     8160

gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga ggcagggaat     8220

gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag aactctgagt     8280

gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc acaggacggg     8340

gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc gtcaagacct     8400

gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca gacgccggcc     8460

atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca ggtcttgaag     8520

gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg ggggccctcc     8580

tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gcgaaggcgc cacatcgttc     8640

ggaagcgcac gctgcggagg ctgctgcagg agagggagct tgtggagcct cttacaccca     8700

gtggagaagc tcccaaccaa gctctcttga ggatcttgaa ggaaactgaa ttcaaaaaga     8760

tcaaagtgct gggctccggt gcgttcggca cggtgtataa gggactctgg atcccagaag     8820

gtgagaaagt taaaattccc gtcgctatca aggaattaag agaagcaaca tctccgaaag     8880

ccaacaagga aatcctcgat gaagcctacg tgatggccag cgtggacaac ccccacgtgt     8940

gccgcctgct gggcatctgc ctcacctcca ccgtgcagct catcacgcag ctcatgccct     9000

tcggctgcct cctggactat gtccgggaac acaaagacaa tattggctcc cagtacctgc     9060

tcaactggtg tgtgcagatc gcaaagggca tgaactactt ggaggaccgt cgcttggtgc     9120

accgcgacct ggcagccagg aacgtactgg tgaaaacacc gcagcatgtc aagatcacag     9180

attttgggct ggccaaactg ctgggtgcgg aagagaaaga ataccatgca gaaggaggca     9240

aagtgcctat caagtggatg gcattggaat caattttaca cagaatctat acccaccaga     9300

gtgatgtctg gagctacggg gtgactgttt gggagttgat gacctttgga tccaagccat     9360

atgacggaat ccctgccagc gagatctcct ccatcctgga gaaaggagaa cgcctccctc     9420

agccacccat atgtaccatc gatgtctaca tgatcatggt caagtgctgg atgatagacg     9480

cagatagtcg cccaaagttc cgtgagttga tcatcgaatt ctccaaaatg gcccgagacc     9540

cccagcgcta ccttgtcatt cagggggatg aaagaatgca tttgccaagt cctacagact     9600

ccaacttcta ccgtgccctg atggatgaag aagacatgga cgacgtggtg gatgccgacg     9660

agtacctcat cccacagcag ggcttcttca gcagcccctc cacgtcacgg actcccctcc     9720

tgagctctct gagtgcaacc agcaacaatt ccaccgtggc ttgcattgat agaaatgggc     9780

tgcaaagctg tcccatcaag gaagacagct tcttgcagcg atacagctca gaccccacag     9840

gcgccttgac tgaggacagc atagacgaca ccttcctccc agtgcctgaa tacataaacc     9900

agtccgttcc caaaaggccc gctggctctg tgcagaatcc tgtctatcac aatcagcctc     9960

tgaaccccgc gcccagcaga gacccacact accaggaccc ccacagcact gcagtgggca    10020

accccgagta tctcaacact gtccagccca cctgtgtcaa cagcacattc gacagccctg    10080

cccactgggc ccagaaaggc agccaccaaa ttagcctgga caaccctgac taccagcagg    10140

acttctttcc caaggaagcc aagccaaatg gcatctttaa gggctccaca gctgaaaatg    10200

cagaatacct aagggtcgcg ccacaaagca gtgaatttat tggagcatga ccacggagga    10260

tagtatgagc cctaaaaatc cagactcttt cgatacccag gaccaagcca cagcaggtcc    10320

tccatcccaa cagccatgcc cgcattagct cttagaccca cagactggtt ttgcaacgtt    10380

tacaccgact agccaggaag tacttccacc tcgggcacat tttgggaagt tgcattcctt    10440

tgtcttcaaa ctgtgaagca tttacagaaa cgcatccagc aagaatattg tccctttgag    10500

cagaaattta tctttcaaag aggtatattt gaaaaaaaaa aaaagtatat gtgaggattt    10560

ttattgattg gggatcttgg agtttttcat tgtcgctatt gatttttact tcaatgggct    10620

cttccaacaa ggaagaagct tgctggtagc acttgctacc ctgagttcat ccaggcccaa    10680

ctgtgagcaa ggagcacaag ccacaagtct tccagaggat gcttgattcc agtggttctg    10740

cttcaaggct tccactgcaa aacactaaag atccaagaag gccttcatgg ccccagcagg    10800

ccggatcggt actgtatcaa gtcatggcag gtacagtagg ataagccact ctgtcccttc    10860

ctgggcaaag aagaaacgga ggggatggaa ttcttcctta gacttacttt tgtaaaaatg    10920

tccccacggt acttactccc cactgatgga ccagtggttt ccagtcatga gcgttagact    10980

gacttgtttg tcttccattc cattgttttg aaactcagta tgctgcccct gtcttgctgt    11040

catgaaatca gcaagagagg atgacacatc aaataataac tcggattcca gcccacattg    11100

gattcatcag catttggacc aatagcccac agctgagaat gtggaatacc taaggatagc    11160

accgcttttg ttctcgcaaa aacgtatctc ctaatttgag gctcagatga aatgcatcag    11220

gtcctttggg gcatagatca gaagactaca aaaatgaagc tgctctgaaa tctcctttag    11280

ccatcacccc aaccccccaa aattagtttg tgttacttat ggaagatagt tttctccttt    11340

tacttcactt caaaagcttt ttactcaaag agtatatgtt ccctccaggt cagctgcccc    11400

caaaccccct ccttacgctt tgtcacacaa aaagtgtctc tgccttgagt catctattca    11460

agcacttaca gctctggcca caacagggca ttttacaggt gcgaatgaca gtagcattat    11520

gagtagtgtg gaattcaggt agtaaatatg aaactagggt ttgaaattga taatgctttc    11580

acaacatttg cagatgtttt agaaggaaaa aagttccttc ctaaaataat ttctctacaa    11640

ttggaagatt ggaagattca gctagttagg agcccacctt ttttcctaat ctgtgtgtgc    11700

cctgtaacct gactggttaa cagcagtcct ttgtaaacag tgttttaaac tctcctagtc    11760

aatatccacc ccatccaatt tatcaaggaa gaaatggttc agaaaatatt ttcagcctac    11820

agttatgttc agtcacacac acatacaaaa tgttcctttt gcttttaaag taatttttga    11880

ctcccagatc agtcagagcc cctacagcat tgttaagaaa gtatttgatt tttgtctcaa    11940

tgaaaataaa actatattca tttccactct attatgctct caaatacccc taagcatcta    12000

tactagcctg gtatgggtat gaaagataca aagataaata aaacatagtc cctgattcta    12060

agaaattcac aatttagcaa aggaaatgga ctcatagatg ctaaccttaa aacaacgtga    12120

caaatgccag acaggaccca tcagccaggc actgtgagag cacagagcag ggaggttggg    12180

tcctgcctga ggagacctgg aagggaggcc tcacaggagg atgaccaggt ctcagtcagc    12240

ggggaggtgg aaagtgcagg tgcatcaggg gcaccctgac cgaggaaaca gctgccagag    12300

gcctccactg ctaaagtcca cataaggctg aggtcagtca ccctaaacaa cctgctccct    12360

ctaagccagg ggatgagctt ggagcatccc acaagttccc taaaagttgc agcccccagg    12420

gggattttga gctatcatct ctgcacatgc ttagtgagaa gactacacaa catttctaag    12480

aatctgagat tttatattgt cagttaacca ctttcattat tcattcacct caggacatgc    12540

agaaatattt cagtcagaac tgggaaacag aaggacctac attctgctgt cacttatgtg    12600

tcaagaagca gatgatcgat gaggcaggtc agttgtaagt gagtcacatt gtagcattaa    12660

attctagtat ttttgtagtt tgaaacagta acttaataaa agagcaaaag ctaaaaaaaa    12720

aaaaaaaaa                                                            12729


<210>  4
<211>  1210
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  5
<211>  5700
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  5
aaaaagagaa actgttggga gaggaatcgt atctccatat ttcttctttc agccccaatc       60

caagggttgt agctggaact ttccatcagt tcttcctttc tttttcctct ctaagccttt      120

gccttgctct gtcacagtga agtcagccag agcagggctg ttaaactctg tgaaatttgt      180

cataagggtg tcaggtattt cttactggct tccaaagaaa catagataaa gaaatctttc      240

ctgtggcttc ccttggcagg ctgcattcag aaggtctctc agttgaagaa agagcttgga      300

ggacaacagc acaacaggag agtaaaagat gccccagggc tgaggcctcc gctcaggcag      360

ccgcatctgg ggtcaatcat actcaccttg cccgggccat gctccagcaa aatcaagctg      420

ttttcttttg aaagttcaaa ctcatcaaga ttatgctgct cactcttatc attctgttgc      480

cagtagtttc aaaatttagt tttgttagtc tctcagcacc gcagcactgg agctgtcctg      540

aaggtactct cgcaggaaat gggaattcta cttgtgtggg tcctgcaccc ttcttaattt      600

tctcccatgg aaatagtatc tttaggattg acacagaagg aaccaattat gagcaattgg      660

tggtggatgc tggtgtctca gtgatcatgg attttcatta taatgagaaa agaatctatt      720

gggtggattt agaaagacaa cttttgcaaa gagtttttct gaatgggtca aggcaagaga      780

gagtatgtaa tatagagaaa aatgtttctg gaatggcaat aaattggata aatgaagaag      840

ttatttggtc aaatcaacag gaaggaatca ttacagtaac agatatgaaa ggaaataatt      900

cccacattct tttaagtgct ttaaaatatc ctgcaaatgt agcagttgat ccagtagaaa      960

ggtttatatt ttggtcttca gaggtggctg gaagccttta tagagcagat ctcgatggtg     1020

tgggagtgaa ggctctgttg gagacatcag agaaaataac agctgtgtca ttggatgtgc     1080

ttgataagcg gctgttttgg attcagtaca acagagaagg aagcaattct cttatttgct     1140

cctgtgatta tgatggaggt tctgtccaca ttagtaaaca tccaacacag cataatttgt     1200

ttgcaatgtc cctttttggt gaccgtatct tctattcaac atggaaaatg aagacaattt     1260

ggatagccaa caaacacact ggaaaggaca tggttagaat taacctccat tcatcatttg     1320

taccacttgg tgaactgaaa gtagtgcatc cacttgcaca acccaaggca gaagatgaca     1380

cttgggagcc tgagcagaaa ctttgcaaat tgaggaaagg aaactgcagc agcactgtgt     1440

gtgggcaaga cctccagtca cacttgtgca tgtgtgcaga gggatacgcc ctaagtcgag     1500

accggaagta ctgtgaagat gttaatgaat gtgctttttg gaatcatggc tgtactcttg     1560

ggtgtaaaaa cacccctgga tcctattact gcacgtgccc tgtaggattt gttctgcttc     1620

ctgatgggaa acgatgtcat caacttgttt cctgtccacg caatgtgtct gaatgcagcc     1680

atgactgtgt tctgacatca gaaggtccct tatgtttctg tcctgaaggc tcagtgcttg     1740

agagagatgg gaaaacatgt agcggttgtt cctcacccga taatggtgga tgtagccagc     1800

tctgcgttcc tcttagccca gtatcctggg aatgtgattg ctttcctggg tatgacctac     1860

aactggatga aaaaagctgt gcagcttcag gaccacaacc atttttgctg tttgccaatt     1920

ctcaagatat tcgacacatg cattttgatg gaacagacta tggaactctg ctcagccagc     1980

agatgggaat ggtttatgcc ctagatcatg accctgtgga aaataagata tactttgccc     2040

atacagccct gaagtggata gagagagcta atatggatgg ttcccagcga gaaaggctta     2100

ttgaggaagg agtagatgtg ccagaaggtc ttgctgtgga ctggattggc cgtagattct     2160

attggacaga cagagggaaa tctctgattg gaaggagtga tttaaatggg aaacgttcca     2220

aaataatcac taaggagaac atctctcaac cacgaggaat tgctgttcat ccaatggcca     2280

agagattatt ctggactgat acagggatta atccacgaat tgaaagttct tccctccaag     2340

gccttggccg tctggttata gccagctctg atctaatctg gcccagtgga ataacgattg     2400

acttcttaac tgacaagttg tactggtgcg atgccaagca gtctgtgatt gaaatggcca     2460

atctggatgg ttcaaaacgc cgaagactta cccagaatga tgtaggtcac ccatttgctg     2520

tagcagtgtt tgaggattat gtgtggttct cagattgggc tatgccatca gtaatgagag     2580

taaacaagag gactggcaaa gatagagtac gtctccaagg cagcatgctg aagccctcat     2640

cactggttgt ggttcatcca ttggcaaaac caggagcaga tccctgctta tatcaaaacg     2700

gaggctgtga acatatttgc aaaaagaggc ttggaactgc ttggtgttcg tgtcgtgaag     2760

gttttatgaa agcctcagat gggaaaacgt gtctggctct ggatggtcat cagctgttgg     2820

caggtggtga agttgatcta aagaaccaag taacaccatt ggacatcttg tccaagacta     2880

gagtgtcaga agataacatt acagaatctc aacacatgct agtggctgaa atcatggtgt     2940

cagatcaaga tgactgtgct cctgtgggat gcagcatgta tgctcggtgt atttcagagg     3000

gagaggatgc cacatgtcag tgtttgaaag gatttgctgg ggatggaaaa ctatgttctg     3060

atatagatga atgtgagatg ggtgtcccag tgtgcccccc tgcctcctcc aagtgcatca     3120

acaccgaagg tggttatgtc tgccggtgct cagaaggcta ccaaggagat gggattcact     3180

gtcttgatat tgatgagtgc caactggggg agcacagctg tggagagaat gccagctgca     3240

caaatacaga gggaggctat acctgcatgt gtgctggacg cctgtctgaa ccaggactga     3300

tttgccctga ctctactcca ccccctcacc tcagggaaga tgaccaccac tattccgtaa     3360

gaaatagtga ctctgaatgt cccctgtccc acgatgggta ctgcctccat gatggtgtgt     3420

gcatgtatat tgaagcattg gacaagtatg catgcaactg tgttgttggc tacatcgggg     3480

agcgatgtca gtaccgagac ctgaagtggt gggaactgcg ccacgctggc cacgggcagc     3540

agcagaaggt catcgtggtg gctgtctgcg tggtggtgct tgtcatgctg ctcctcctga     3600

gcctgtgggg ggcccactac tacaggactc agaagctgct atcgaaaaac ccaaagaatc     3660

cttatgagga gtcgagcaga gatgtgagga gtcgcaggcc tgctgacact gaggatggga     3720

tgtcctcttg ccctcaacct tggtttgtgg ttataaaaga acaccaagac ctcaagaatg     3780

ggggtcaacc agtggctggt gaggatggcc aggcagcaga tgggtcaatg caaccaactt     3840

catggaggca ggagccccag ttatgtggaa tgggcacaga gcaaggctgc tggattccag     3900

tatccagtga taagggctcc tgtccccagg taatggagcg aagctttcat atgccctcct     3960

atgggacaca gacccttgaa gggggtgtcg agaagcccca ttctctccta tcagctaacc     4020

cattatggca acaaagggcc ctggacccac cacaccaaat ggagctgact cagtgaaaac     4080

tggaattaaa aggaaagtca agaagaatga actatgtcga tgcacagtat cttttctttc     4140

aaaagtagag caaaactata ggttttggtt ccacaatctc tacgactaat cacctactca     4200

atgcctggag acagatacgt agttgtgctt ttgtttgctc ttttaagcag tctcactgca     4260

gtcttatttc caagtaagag tactgggaga atcactaggt aacttattag aaacccaaat     4320

tgggacaaca gtgctttgta aattgtgttg tcttcagcag tcaatacaaa tagatttttg     4380

tttttgttgt tcctgcagcc ccagaagaaa ttaggggtta aagcagacag tcacactggt     4440

ttggtcagtt acaaagtaat ttctttgatc tggacagaac atttatatca gtttcatgaa     4500

atgattggaa tattacaata ccgttaagat acagtgtagg catttaactc ctcattggcg     4560

tggtccatgc tgatgatttt gcaaaatgag ttgtgatgaa tcaatgaaaa atgtaattta     4620

gaaactgatt tcttcagaat tagatggctt attttttaaa atatttgaat gaaaacattt     4680

tatttttaaa atattacaca ggaggcttcg gagtttctta gtcattactg tccttttccc     4740

ctacagaatt ttccctcttg gtgtgattgc acagaatttg tatgtatttt cagttacaag     4800

attgtaagta aattgcctga tttgttttca ttatagacaa cgatgaattt cttctaatta     4860

tttaaataaa atcaccaaaa acataaacat tttattgtat gcctgattaa gtagttaatt     4920

atagtctaag gcagtactag agttgaacca aaatgatttg tcaagcttgc tgatgtttct     4980

gtttttcgtt tttttttttt ttccggagag aggataggat ctcactctgt tatccaggct     5040

ggagtgtgca atggcacaat catagctcag tgcagcctca aactcctggg ctcaagcaat     5100

cctcctgcct cagcctcccg agtaactagg accacaggca caggccacca tgcctggcta     5160

aggtttttat ttttattttt tgtagacatg gggatcacac aatgttgccc aggctggtct     5220

tgaactcctg gcctcaagca aggtcgtgct ggtaattttg caaaatgaat tgtgattgac     5280

tttcagcctc ccaacgtatt agattatagg cattagccat ggtgcccagc cttgtaactt     5340

ttaaaaaaat tttttaatct acaactctgt agattaaaat ttcacatggt gttctaatta     5400

aatatttttc ttgcagccaa gatattgtta ctacagataa cacaacctga tatggtaact     5460

ttaaattttg ggggctttga atcattcagt ttatgcatta actagtccct ttgtttatct     5520

ttcatttctc aaccccttgt actttggtga taccagacat cagaataaaa agaaattgaa     5580

gtacctgttt tcaaatggat actttatagg aattttggta aagatttggt gatgggagga     5640

tgacttgagg tttgtggata ttagttaatt attcagtatg atacctcacc cagctaattt     5700


<210>  6
<211>  1207
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                 920                 925             


Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                 935                 940                 


Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                 950                 955                 960 


Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                 970                 975     


Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                 985                 990         


Ile Glu Ala Leu Asp Lys Tyr Ala  Cys Asn Cys Val Val  Gly Tyr Ile 
        995                 1000                 1005             


Gly Glu  Arg Cys Gln Tyr Arg  Asp Leu Lys Trp Trp  Glu Leu Arg 
    1010                 1015                 1020             


His Ala  Gly His Gly Gln Gln  Gln Lys Val Ile Val  Val Ala Val 
    1025                 1030                 1035             


Cys Val  Val Val Leu Val Met  Leu Leu Leu Leu Ser  Leu Trp Gly 
    1040                 1045                 1050             


Ala His  Tyr Tyr Arg Thr Gln  Lys Leu Leu Ser Lys  Asn Pro Lys 
    1055                 1060                 1065             


Asn Pro  Tyr Glu Glu Ser Ser  Arg Asp Val Arg Ser  Arg Arg Pro 
    1070                 1075                 1080             


Ala Asp  Thr Glu Asp Gly Met  Ser Ser Cys Pro Gln  Pro Trp Phe 
    1085                 1090                 1095             


Val Val  Ile Lys Glu His Gln  Asp Leu Lys Asn Gly  Gly Gln Pro 
    1100                 1105                 1110             


Val Ala  Gly Glu Asp Gly Gln  Ala Ala Asp Gly Ser  Met Gln Pro 
    1115                 1120                 1125             


Thr Ser  Trp Arg Gln Glu Pro  Gln Leu Cys Gly Met  Gly Thr Glu 
    1130                 1135                 1140             


Gln Gly  Cys Trp Ile Pro Val  Ser Ser Asp Lys Gly  Ser Cys Pro 
    1145                 1150                 1155             


Gln Val  Met Glu Arg Ser Phe  His Met Pro Ser Tyr  Gly Thr Gln 
    1160                 1165                 1170             


Thr Leu  Glu Gly Gly Val Glu  Lys Pro His Ser Leu  Leu Ser Ala 
    1175                 1180                 1185             


Asn Pro  Leu Trp Gln Gln Arg  Ala Leu Asp Pro Pro  His Gln Met 
    1190                 1195                 1200             


Glu Leu  Thr Gln 
    1205         


<210>  7
<211>  2106
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  7
gagcccttgg accaaactcg cctgcgccga gagccgtccg cgtagagcgc tccgtctccg       60

gcgagatgtc cgagcgcaaa gaaggcagag gcaaagggaa gggcaagaag aaggagcgag      120

gctccggcaa gaagccggag tccgcggcgg gcagccagag cccagccttg cctccccaat      180

tgaaagagat gaaaagccag gaatcggctg caggttccaa actagtcctt cggtgtgaaa      240

ccagttctga atactcctct ctcagattca agtggttcaa gaatgggaat gaattgaatc      300

gaaaaaacaa accacaaaat atcaagatac aaaaaaagcc agggaagtca gaacttcgca      360

ttaacaaagc atcactggct gattctggag agtatatgtg caaagtgatc agcaaattag      420

gaaatgacag tgcctctgcc aatatcacca tcgtggaatc aaacgagatc atcactggta      480

tgccagcctc aactgaagga gcatatgtgt cttcagagtc tcccattaga atatcagtat      540

ccacagaagg agcaaatact tcttcatcta catctacatc caccactggg acaagccatc      600

ttgtaaaatg tgcggagaag gagaaaactt tctgtgtgaa tggaggggag tgcttcatgg      660

tgaaagacct ttcaaacccc tcgagatact tgtgcaagtg ccaacctgga ttcactggag      720

caagatgtac tgagaatgtg cccatgaaag tccaaaacca agaaaaggcg gaggagctgt      780

accagaagag agtgctgacc ataaccggca tctgcatcgc cctccttgtg gtcggcatca      840

tgtgtttggt ggcctactgc aaaaccaaga aacagcggaa aaagctgcat gaccgtcttc      900

ggcagagcct tcggtctgaa cgaaacaata tgatgaacat tgccaatggg cctcaccatc      960

ctaacccacc ccccgagaat gtccagctgg tgaatcaata cgtatctaaa aacgtcatct     1020

ccagtgagca tattgttgag agagaagcag agacatcctt ttccaccagt cactatactt     1080

ccacagccca tcactccact actgtcaccc agactcctag ccacagctgg agcaacggac     1140

acactgaaag catcctttcc gaaagccact ctgtaatcgt gatgtcatcc gtagaaaaca     1200

gtaggcacag cagcccaact gggggcccaa gaggacgtct taatggcaca ggaggccctc     1260

gtgaatgtaa cagcttcctc aggcatgcca gagaaacccc tgattcctac cgagactctc     1320

ctcatagtga aaggtatgtg tcagccatga ccaccccggc tcgtatgtca cctgtagatt     1380

tccacacgcc aagctccccc aaatcgcccc cttcggaaat gtctccaccc gtgtccagca     1440

tgacggtgtc catgccttcc atggcggtca gccccttcat ggaagaagag agacctctac     1500

ttctcgtgac accaccaagg ctgcgggaga agaagtttga ccatcaccct cagcagttca     1560

gctccttcca ccacaacccc gcgcatgaca gtaacagcct ccctgctagc cccttgagga     1620

tagtggagga tgaggagtat gaaacgaccc aagagtacga gccagcccaa gagcctgtta     1680

agaaactcgc caatagccgg cgggccaaaa gaaccaagcc caatggccac attgctaaca     1740

gattggaagt ggacagcaac acaagctccc agagcagtaa ctcagagagt gaaacagaag     1800

atgaaagagt aggtgaagat acgcctttcc tgggcataca gaaccccctg gcagccagtc     1860

ttgaggcaac acctgccttc cgcctggctg acagcaggac taacccagca ggccgcttct     1920

cgacacagga agaaatccag gccaggctgt ctagtgtaat tgctaaccaa gaccctattg     1980

ctgtataaaa cctaaataaa cacatagatt cacctgtaaa actttatttt atataataaa     2040

gtattccacc ttaaattaaa caatttattt tattttagca gttctgcaaa tagaaaacag     2100

gaaaaa                                                                2106


<210>  8
<211>  640
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Gln Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys Thr Glu Asn 
    210                 215                 220                 


Val Pro Met Lys Val Gln Asn Gln Glu Lys Ala Glu Glu Leu Tyr Gln 
225                 230                 235                 240 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
                245                 250                 255     


Gly Ile Met Cys Leu Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
            260                 265                 270         


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
        275                 280                 285             


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
    290                 295                 300                 


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
305                 310                 315                 320 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
                325                 330                 335     


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
            340                 345                 350         


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
        355                 360                 365             


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
    370                 375                 380                 


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
385                 390                 395                 400 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
                405                 410                 415     


Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
            420                 425                 430         


Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
        435                 440                 445             


Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
    450                 455                 460                 


Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
465                 470                 475                 480 


Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
                485                 490                 495     


Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
            500                 505                 510         


Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
        515                 520                 525             


Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
    530                 535                 540                 


Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
545                 550                 555                 560 


Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
                565                 570                 575     


Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
            580                 585                 590         


Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
        595                 600                 605             


Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
    610                 615                 620                 


Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
625                 630                 635                 640 


<210>  9
<211>  6661
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  9
ggcttaactg atgcctgcct gcctctcttt gatttgatgg cctttattcc ttctaattgg       60

ataaaatagg aagtcactgg cagtcctgtg tggctgggga tactgatttt actcagacca      120

gcctgcagct ctagagtgtg ggtagagagc ggggagtggg ggttgggaga gggggaggaa      180

agagagagag gagagaggac gggcttggat gaagaaggga aagaaagaga aagagactga      240

agcagagaag agccgcagag gaagaaagtg aatgagcact caagaaggac aaagaggagt      300

agtcgggggt ggggtggagg cagggcgggg aagggagtga ccgcccctcc tggctgcact      360

cttgcctccg gagccctctg atcctgtttg cagtgatgct ccgagggcag gcacctgctg      420

ctctgtaatg attcagcccc tttcagccgt cgtcgcgtta acacaacagg atgctgttgc      480

tattgtcact actgcctctc ctgccgccgc tgctgctgcc gccgccgcca ccgccgctgg      540

tcctccttct gcttttactt ctcctgcatg acagttgttt tcttcatctg agcagacacc      600

agcttcagat gctcgaggtg agaaacatgc ctttcagttt gggctactgg tttacttaat      660

taatcagccg gcagctccgt cgatctattt tcgtccctgt cctcttgacg agcccgggat      720

ggtttggagt agcatttaaa agaactagaa aagtggccca gaaacagcag cttaaagaat      780

tattacgata tactttgatt ttgtagttgc taggagcttt tcttcccccc ttgcatcttt      840

ctgaactctt cttgatttta ataatggcct tggacttgga cgatttatcg atttccccct      900

gtaagatgct gtatcatttg gttggggggg cctctgcgtg gtaatggacc gtgagagcgg      960

ccaggccttc ttctggaggt gagccgatgg agatttattc cccagacatg tctgaggtcg     1020

ccgccgagag gtcctccagc ccctccactc agctgagtgc agacccatct cttgatgggc     1080

ttccggcagc agaagacatg ccagagcccc agactgaaga tgggagaacc cctggactcg     1140

tgggcctggc cgtgccctgc tgtgcgtgcc tagaagctga gcgcctgaga ggttgcctca     1200

actcagagaa aatctgcatt gtccccatcc tggcttgcct ggtcagcctc tgcctctgca     1260

tcgccggcct caagtgggta tttgtggaca agatctttga atatgactct cctactcacc     1320

ttgaccctgg ggggttaggc caggacccta ttatttctct ggacgcaact gctgcctcag     1380

ctgtgtgggt gtcgtctgag gcatacactt cacctgtctc tagggctcaa tctgaaagtg     1440

aggttcaagt tacagtgcaa ggtgacaagg ctgttgtctc ctttgaacca tcagcggcac     1500

cgacaccgaa gaatcgtatt tttgcctttt ctttcttgcc gtccactgcg ccatccttcc     1560

cttcacccac ccggaaccct gaggtgagaa cgcccaagtc agcaactcag ccacaaacaa     1620

cagaaactaa tctccaaact gctcctaaac tttctacatc tacatccacc actgggacaa     1680

gccatcttgt aaaatgtgcg gagaaggaga aaactttctg tgtgaatgga ggggagtgct     1740

tcatggtgaa agacctttca aacccctcga gatacttgtg caagtgccca aatgagttta     1800

ctggtgatcg ctgccaaaac tacgtaatgg ccagcttcta caagcatctt gggattgaat     1860

ttatggaggc ggaggagctg taccagaaga gagtgctgac cataaccggc atctgcatcg     1920

ccctccttgt ggtcggcatc atgtgtgtgg tggcctactg caaaaccaag aaacagcgga     1980

aaaagctgca tgaccgtctt cggcagagcc ttcggtctga acgaaacaat atgatgaaca     2040

ttgccaatgg gcctcaccat cctaacccac cccccgagaa tgtccagctg gtgaatcaat     2100

acgtatctaa aaacgtcatc tccagtgagc atattgttga gagagaagca gagacatcct     2160

tttccaccag tcactatact tccacagccc atcactccac tactgtcacc cagactccta     2220

gccacagctg gagcaacgga cacactgaaa gcatcctttc cgaaagccac tctgtaatcg     2280

tgatgtcatc cgtagaaaac agtaggcaca gcagcccaac tgggggccca agaggacgtc     2340

ttaatggcac aggaggccct cgtgaatgta acagcttcct caggcatgcc agagaaaccc     2400

ctgattccta ccgagactct cctcatagtg aaaggtatgt gtcagccatg accaccccgg     2460

ctcgtatgtc acctgtagat ttccacacgc caagctcccc caaatcgccc ccttcggaaa     2520

tgtctccacc cgtgtccagc atgacggtgt ccatgccttc catggcggtc agccccttca     2580

tggaagaaga gagacctcta cttctcgtga caccaccaag gctgcgggag aagaagtttg     2640

accatcaccc tcagcagttc agctccttcc accacaaccc cgcgcatgac agtaacagcc     2700

tccctgctag ccccttgagg atagtggagg atgaggagta tgaaacgacc caagagtacg     2760

agccagccca agagcctgtt aagaaactcg ccaatagccg gcgggccaaa agaaccaagc     2820

ccaatggcca cattgctaac agattggaag tggacagcaa cacaagctcc cagagcagta     2880

actcagagag tgaaacagaa gatgaaagag taggtgaaga tacgcctttc ctgggcatac     2940

agaaccccct ggcagccagt cttgaggcaa cacctgcctt ccgcctggct gacagcagga     3000

ctaacccagc aggccgcttc tcgacacagg aagaaatcca ggccaggctg tctagtgtaa     3060

ttgctaacca agaccctatt gctgtataaa acctaaataa acacatagat tcacctgtaa     3120

aactttattt tatataataa agtattccac cttaaattaa acaatttatt ttattttagc     3180

agttctgcaa atagaaaaca ggaaaaaaac ttttataaat taaatatatg tatgtaaaaa     3240

tgtgttatgt gccatatgta gcaatttttt acagtatttc aaaacgagaa agatatcaat     3300

ggtgccttta tgttatgtta tgtcgagagc aagttttgta cagttacagt gattgctttt     3360

ccacagtatt tctgcaaaac ctctcataga ttcagttttt gctggcttct tgtgcattgc     3420

attatgatgt tgactggatg tatgatttgc aagacttgca actgtccctc tgtttgcttg     3480

tagtagcacc cgatcagtat gtcttgtaat ggcacatcca tccagatatg cctctcttgt     3540

gtatgaagtt ttctttgctt tcagaatatg aaatgagttg tgtctactct gccagccaaa     3600

ggtttgcctc attgggctct gagataatag tagatccaac agcatgctac tattaaatac     3660

agcaagaaac tgcattaagt aatgttaaat attaggaaga aagtaatact gtgatttaaa     3720

aaaaactata ttattaatca gaagacagct tgctcttact aaaaggagct ctcatttact     3780

ttatttgatt ttatttttct tgacaaaaag caacagtttt agggatagct tagaaaatgg     3840

gttctggctt gctatcaggg taaatctaac accttacaag aggactgagt gtcactttct     3900

ctctggggga atgatccagc agcttatcta gttgacaatc aaaacacggc tgataaaggt     3960

gcaatcattt ctgacatgta tttttcactg attttgaagc tagtgattgg ttgtgtcttc     4020

ttggctcaaa aagaagcata ttacggcaca aaaagcccag cccagacagc acatgcagca     4080

ttttgtctga aatacttcta gagtcaaacg tgcctgctgt acatagcgat gacttgtcat     4140

catagggaag tatttccatc gtagagtgtt cagaaggagt gactgtatag gtggagagaa     4200

gcttagtgac tccgttgaaa ttttaaaatg tggatgacca cccctttctc ccccttattt     4260

ttcttttatc tttccatgtt gccttgatca ggtcataact atgcatgaac attttttatc     4320

aggaatggcc gatgtgtatg tgatttgtaa tcacaagtaa tgattcatca ggaaatgtca     4380

atcctgttgg aaagattgca cctttacttg cagaagtgac ccccacctgt gtcctgacct     4440

ctccatttac aggctctctc acccatttcc cccacctcct ttaatttttg ctttactgtc     4500

ataaagtagg actaagattg gtctaagcat tgcatgttct tttgtgatgg taaatccaaa     4560

ggaaggccta taagtattaa catttgaaat aactgctaat tcaggaaaat ggaagaaaaa     4620

aaattatttg aaacacagaa cccatttcat ggcctgcctg atatctgtga aatcagggct     4680

ggagctttac ttaggattca catggcctcc taggaaccat gggacaaatg ggaaacaggt     4740

tatcggggga ttcatgaagt cagtgagagt aattgcttct tttttgcggg tgaactgaat     4800

gtatttcttc accaaatctt gatgttaaca attaaaaaga agaaatgaca tgcaagtagg     4860

tcttagcaga aaaatgcagg ctgggcatga gtcatgttgt taccctccca catgctccta     4920

caatccacag agatgcctgt ctgcaggttc ttgaagttat tgttagtatt tggtatctca     4980

aatttttcgt cactgttcac atgccacttt ctctgtgcac agtggtatcc tcatttgctt     5040

tttaacctac actgaggagt ctttgtcagg ttgcactgat tttccaattc tgcagtaatg     5100

agtaagctca cggcatgggg aagaagacag tcagtccaat gaagttctct aaattatttt     5160

aacattgcct ttgaaggcct tgactcatcc ttagctattt caatgaagaa attcctacca     5220

tgaatttaaa accctaaaaa ttctgtttca aattctttgg gcattggggt actcagatat     5280

cccattgtgg aagaatttta agaataaata gaagtttctg ttgagaacca tgagcaacat     5340

gtttcttaca atgagaattg ctatgcattt taaaattgca aatatatatg aaaattgaag     5400

acaagaggaa attgtatttc taacttgatt ctgatcactc acagaggtgg catattatta     5460

tagttgggac atcctttgca cccttcataa aaaaggccag ctgactgctc agcatcacct     5520

gccaaggcca ctagatttgt gtttacaggg gtatctctgt gatgcttgtc acatcactct     5580

tgaccacctc tgttaataaa ttccgacagt gcagtggcga tcggagtgtg aacttatgtt     5640

cccagcatat ggaaagctat cttaggtttt aaggtagtag aaattgccca ggagtttgac     5700

agcaactttg tttcccgggt ctaaaatcgt atcccactga ggtgtatgca gtggagcata     5760

atacatgcaa atacatgcaa aactcctttt gtttcaccta agattcactt tctatcttac     5820

tttcccttcc tgcctagtgt gacttttgcc cccaagagtg cctggacagc attctagttt     5880

ctacaaaatg gtcctctgtg taggtgaatg tgtcccaaac ctgctatcac tttcttgttt     5940

cagtgtgact gtcttgttag aggtgaagtt tatccagggt aacttgctca ctaactattc     6000

ctttttatgg cctggggtta aagggcgcat ggctcacact ggtgaaaata aggaaggcct     6060

ggtcttatct tgtattaata atactggctg cattccacca gccagagatt tctatctgcg     6120

aagacctatg aaacactgaa gagaaatgta ggcagaagga aatggccaca tatcacaagt     6180

tctattatat attcttttgt aaatacatat tgtatattac ttggatgttt tcttatatca     6240

tttactgtct ttttgagtta atgtcagttt ttactctctc aacttactat gtaacattgt     6300

aaataacata atgtccttta ttatttatat ttaagcatct aacatataga gttgttttca     6360

tataagttta agataaatgt caaaaatata tgttcttttg tttttctttg ctttaaaatt     6420

atgtatcttt tccttttctt ttttttaaga ataatttatt gttcaggaga aagaatgtat     6480

atgtaactga aactatctga agaatgcaca ttgaaggccg tgaggtactg ataaactaaa     6540

gaatttatta ttcaaaatac taagcaataa gtaattgtga tttatttaaa gttttgtcca     6600

ttttccatga aagacatact gcaataaaaa tgctactctg tggaaaaaaa aaaaaaaaaa     6660

a                                                                     6661


<210>  10
<211>  700
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Met Glu Ile Tyr Ser Pro Asp Met Ser Glu Val Ala Ala Glu Arg Ser 
1               5                   10                  15      


Ser Ser Pro Ser Thr Gln Leu Ser Ala Asp Pro Ser Leu Asp Gly Leu 
            20                  25                  30          


Pro Ala Ala Glu Asp Met Pro Glu Pro Gln Thr Glu Asp Gly Arg Thr 
        35                  40                  45              


Pro Gly Leu Val Gly Leu Ala Val Pro Cys Cys Ala Cys Leu Glu Ala 
    50                  55                  60                  


Glu Arg Leu Arg Gly Cys Leu Asn Ser Glu Lys Ile Cys Ile Val Pro 
65                  70                  75                  80  


Ile Leu Ala Cys Leu Val Ser Leu Cys Leu Cys Ile Ala Gly Leu Lys 
                85                  90                  95      


Trp Val Phe Val Asp Lys Ile Phe Glu Tyr Asp Ser Pro Thr His Leu 
            100                 105                 110         


Asp Pro Gly Gly Leu Gly Gln Asp Pro Ile Ile Ser Leu Asp Ala Thr 
        115                 120                 125             


Ala Ala Ser Ala Val Trp Val Ser Ser Glu Ala Tyr Thr Ser Pro Val 
    130                 135                 140                 


Ser Arg Ala Gln Ser Glu Ser Glu Val Gln Val Thr Val Gln Gly Asp 
145                 150                 155                 160 


Lys Ala Val Val Ser Phe Glu Pro Ser Ala Ala Pro Thr Pro Lys Asn 
                165                 170                 175     


Arg Ile Phe Ala Phe Ser Phe Leu Pro Ser Thr Ala Pro Ser Phe Pro 
            180                 185                 190         


Ser Pro Thr Arg Asn Pro Glu Val Arg Thr Pro Lys Ser Ala Thr Gln 
        195                 200                 205             


Pro Gln Thr Thr Glu Thr Asn Leu Gln Thr Ala Pro Lys Leu Ser Thr 
    210                 215                 220                 


Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys 
225                 230                 235                 240 


Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp 
                245                 250                 255     


Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr 
            260                 265                 270         


Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys His Leu 
        275                 280                 285             


Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu 
    290                 295                 300                 


Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met Cys 
305                 310                 315                 320 


Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His Asp 
                325                 330                 335     


Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn Ile 
            340                 345                 350         


Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln Leu 
        355                 360                 365             


Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile Val 
    370                 375                 380                 


Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr 
385                 390                 395                 400 


Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp Ser 
                405                 410                 415     


Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile Val 
            420                 425                 430         


Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly Pro 
        435                 440                 445             


Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser Phe 
    450                 455                 460                 


Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro His 
465                 470                 475                 480 


Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser Pro 
                485                 490                 495     


Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu Met 
            500                 505                 510         


Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met Ala Val 
        515                 520                 525             


Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro Pro 
    530                 535                 540                 


Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe Ser Ser 
545                 550                 555                 560 


Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser Pro 
                565                 570                 575     


Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu 
            580                 585                 590         


Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala Lys 
        595                 600                 605             


Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp Ser 
    610                 615                 620                 


Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu 
625                 630                 635                 640 


Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala 
                645                 650                 655     


Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg Thr 
            660                 665                 670         


Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg Leu 
        675                 680                 685             


Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
    690                 695                 700 


<210>  11
<211>  55
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  11

Gly Thr Ser His Leu Val Lys Cys Pro Leu Ser His Glu Ala Tyr Cys 
1               5                   10                  15      


Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser 
            20                  25                  30          


Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln 
        35                  40                  45              


Asn Tyr Val Met Ala Ser Phe 
    50                  55  


<210>  12
<211>  53
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Asn Thr Glu Asn Asp Cys Pro Leu Ser His Glu Ala Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys Val 
            20                  25                  30          


Cys Val Val Gly Tyr Val Gly Glu Arg Cys Gln Phe Arg Asp Leu Arg 
        35                  40                  45              


Trp Trp Asp Ala Arg 
    50              


<210>  13
<211>  173
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Met Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu Tyr His Asn Thr 
1               5                   10                  15      


Gln Ile His Thr Leu Asn Asp Lys Ile Phe Ser Tyr Thr Glu Ser Leu 
            20                  25                  30          


Ala Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys Asn Gly Ala Thr 
        35                  40                  45              


Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys 
    50                  55                  60                  


Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala Tyr Leu Thr Glu 
65                  70                  75                  80  


Ala Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys Thr Pro His Ala 
                85                  90                  95      


Ile Ala Ala Ile Ser Met Ala Asn Ser Ser Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Ser Gly Thr Phe Tyr Asp Ile Glu Thr Leu Lys Val Ile Asp Glu Glu 
        115                 120                 125             


Trp Gln Arg Thr Gln Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe 
    130                 135                 140                 


Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val 
145                 150                 155                 160 


Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly 
                165                 170             


<210>  14
<211>  172
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu Tyr His Asn Thr Gln 
1               5                   10                  15      


Ile His Thr Leu Asn Asp Lys Ile Phe Ser Tyr Thr Glu Ser Leu Ala 
            20                  25                  30          


Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys Asn Gly Ala Thr Phe 
        35                  40                  45              


Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys Ala 
    50                  55                  60                  


Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala Tyr Leu Thr Glu Ala 
65                  70                  75                  80  


Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys Thr Pro His Ala Ile 
                85                  90                  95      


Ala Ala Ile Ser Met Ala Asn Ser Ser Gly Gly Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Thr Phe Tyr Asp Ile Glu Thr Leu Lys Val Ile Asp Glu Glu Trp 
        115                 120                 125             


Gln Arg Thr Gln Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln 
    130                 135                 140                 


Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro 
145                 150                 155                 160 


Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly 
                165                 170         


<210>  15
<211>  3660
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  15
gcggaggctt ggggcagccg ggtagctcgg aggtcgtggc gctgggggct agcaccagcg       60

ctctgtcggg aggcgcagcg gttaggtgga ccggtcagcg gactcaccgg ccagggcgct      120

cggtgctgga atttgatatt cattgatccg ggttttatcc ctcttctttt ttcttaaaca      180

ttttttttta aaactgtatt gtttctcgtt ttaatttatt tttgcttgcc attccccact      240

tgaatcgggc cgacggcttg gggagattgc tctacttccc caaatcactg tggattttgg      300

aaaccagcag aaagaggaaa gaggtagcaa gagctccaga gagaagtcga ggaagagaga      360

gacggggtca gagagagcgc gcgggcgtgc gagcagcgaa agcgacaggg gcaaagtgag      420

tgacctgctt ttgggggtga ccgccggagc gcggcgtgag ccctccccct tgggatcccg      480

cagctgacca gtcgcgctga cggacagaca gacagacacc gcccccagcc ccagctacca      540

cctcctcccc ggccggcggc ggacagtgga cgcggcggcg agccgcgggc aggggccgga      600

gcccgcgccc ggaggcgggg tggagggggt cggggctcgc ggcgtcgcac tgaaactttt      660

cgtccaactt ctgggctgtt ctcgcttcgg aggagccgtg gtccgcgcgg gggaagccga      720

gccgagcgga gccgcgagaa gtgctagctc gggccgggag gagccgcagc cggaggaggg      780

ggaggaggaa gaagagaagg aagaggagag ggggccgcag tggcgactcg gcgctcggaa      840

gccgggctca tggacgggtg aggcggcggt gtgcgcagac agtgctccag ccgcgcgcgc      900

tccccaggcc ctggcccggg cctcgggccg gggaggaaga gtagctcgcc gaggcgccga      960

ggagagcggg ccgccccaca gcccgagccg gagagggagc gcgagccgcg ccggccccgg     1020

tcgggcctcc gaaaccatga actttctgct gtcttgggtg cattggagcc ttgccttgct     1080

gctctacctc caccatgcca agtggtccca ggctgcaccc atggcagaag gaggagggca     1140

gaatcatcac gaagtggtga agttcatgga tgtctatcag cgcagctact gccatccaat     1200

cgagaccctg gtggacatct tccaggagta ccctgatgag atcgagtaca tcttcaagcc     1260

atcctgtgtg cccctgatgc gatgcggggg ctgctgcaat gacgagggcc tggagtgtgt     1320

gcccactgag gagtccaaca tcaccatgca gattatgcgg atcaaacctc accaaggcca     1380

gcacatagga gagatgagct tcctacagca caacaaatgt gaatgcagac caaagaaaga     1440

tagagcaaga caagaaaaaa aatcagttcg aggaaaggga aaggggcaaa aacgaaagcg     1500

caagaaatcc cggtataagt cctggagcgt gtacgttggt gcccgctgct gtctaatgcc     1560

ctggagcctc cctggccccc atccctgtgg gccttgctca gagcggagaa agcatttgtt     1620

tgtacaagat ccgcagacgt gtaaatgttc ctgcaaaaac acagactcgc gttgcaaggc     1680

gaggcagctt gagttaaacg aacgtacttg cagatgtgac aagccgaggc ggtgagccgg     1740

gcaggaggaa ggagcctccc tcagggtttc gggaaccaga tctctcacca ggaaagactg     1800

atacagaacg atcgatacag aaaccacgct gccgccacca caccatcacc atcgacagaa     1860

cagtccttaa tccagaaacc tgaaatgaag gaagaggaga ctctgcgcag agcactttgg     1920

gtccggaggg cgagactccg gcggaagcat tcccgggcgg gtgacccagc acggtccctc     1980

ttggaattgg attcgccatt ttatttttct tgctgctaaa tcaccgagcc cggaagatta     2040

gagagtttta tttctgggat tcctgtagac acacccaccc acatacatac atttatatat     2100

atatatatta tatatatata aaaataaata tctctatttt atatatataa aatatatata     2160

ttcttttttt aaattaacag tgctaatgtt attggtgtct tcactggatg tatttgactg     2220

ctgtggactt gagttgggag gggaatgttc ccactcagat cctgacaggg aagaggagga     2280

gatgagagac tctggcatga tctttttttt gtcccacttg gtggggccag ggtcctctcc     2340

cctgcccagg aatgtgcaag gccagggcat gggggcaaat atgacccagt tttgggaaca     2400

ccgacaaacc cagccctggc gctgagcctc tctaccccag gtcagacgga cagaaagaca     2460

gatcacaggt acagggatga ggacaccggc tctgaccagg agtttgggga gcttcaggac     2520

attgctgtgc tttggggatt ccctccacat gctgcacgcg catctcgccc ccaggggcac     2580

tgcctggaag attcaggagc ctgggcggcc ttcgcttact ctcacctgct tctgagttgc     2640

ccaggagacc actggcagat gtcccggcga agagaagaga cacattgttg gaagaagcag     2700

cccatgacag ctccccttcc tgggactcgc cctcatcctc ttcctgctcc ccttcctggg     2760

gtgcagccta aaaggaccta tgtcctcaca ccattgaaac cactagttct gtccccccag     2820

gagacctggt tgtgtgtgtg tgagtggttg accttcctcc atcccctggt ccttcccttc     2880

ccttcccgag gcacagagag acagggcagg atccacgtgc ccattgtgga ggcagagaaa     2940

agagaaagtg ttttatatac ggtacttatt taatatccct ttttaattag aaattaaaac     3000

agttaattta attaaagagt agggtttttt ttcagtattc ttggttaata tttaatttca     3060

actatttatg agatgtatct tttgctctct cttgctctct tatttgtacc ggtttttgta     3120

tataaaattc atgtttccaa tctctctctc cctgatcggt gacagtcact agcttatctt     3180

gaacagatat ttaattttgc taacactcag ctctgccctc cccgatcccc tggctcccca     3240

gcacacattc ctttgaaata aggtttcaat atacatctac atactatata tatatttggc     3300

aacttgtatt tgtgtgtata tatatatata tatgtttatg tatatatgtg attctgataa     3360

aatagacatt gctattctgt tttttatatg taaaaacaaa acaagaaaaa atagagaatt     3420

ctacatacta aatctctctc cttttttaat tttaatattt gttatcattt atttattggt     3480

gctactgttt atccgtaata attgtgggga aaagatatta acatcacgtc tttgtctcta     3540

gtgcagtttt tcgagatatt ccgtagtaca tatttatttt taaacaacga caaagaaata     3600

cagatatatc ttaaaaaaaa aaaagcattt tgtattaaag aatttaattc tgatctcaaa     3660


<210>  16
<211>  412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Met Thr Asp Arg Gln Thr Asp Thr Ala Pro Ser Pro Ser Tyr His Leu 
1               5                   10                  15      


Leu Pro Gly Arg Arg Arg Thr Val Asp Ala Ala Ala Ser Arg Gly Gln 
            20                  25                  30          


Gly Pro Glu Pro Ala Pro Gly Gly Gly Val Glu Gly Val Gly Ala Arg 
        35                  40                  45              


Gly Val Ala Leu Lys Leu Phe Val Gln Leu Leu Gly Cys Ser Arg Phe 
    50                  55                  60                  


Gly Gly Ala Val Val Arg Ala Gly Glu Ala Glu Pro Ser Gly Ala Ala 
65                  70                  75                  80  


Arg Ser Ala Ser Ser Gly Arg Glu Glu Pro Gln Pro Glu Glu Gly Glu 
                85                  90                  95      


Glu Glu Glu Glu Lys Glu Glu Glu Arg Gly Pro Gln Trp Arg Leu Gly 
            100                 105                 110         


Ala Arg Lys Pro Gly Ser Trp Thr Gly Glu Ala Ala Val Cys Ala Asp 
        115                 120                 125             


Ser Ala Pro Ala Ala Arg Ala Pro Gln Ala Leu Ala Arg Ala Ser Gly 
    130                 135                 140                 


Arg Gly Gly Arg Val Ala Arg Arg Gly Ala Glu Glu Ser Gly Pro Pro 
145                 150                 155                 160 


His Ser Pro Ser Arg Arg Gly Ser Ala Ser Arg Ala Gly Pro Gly Arg 
                165                 170                 175     


Ala Ser Glu Thr Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu 
            180                 185                 190         


Ala Leu Leu Leu Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro 
        195                 200                 205             


Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys Phe Met 
    210                 215                 220                 


Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp 
225                 230                 235                 240 


Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser 
                245                 250                 255     


Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu 
            260                 265                 270         


Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg 
        275                 280                 285             


Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln 
    290                 295                 300                 


His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu 
305                 310                 315                 320 


Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys 
                325                 330                 335     


Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys 
            340                 345                 350         


Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser 
        355                 360                 365             


Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys 
    370                 375                 380                 


Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu 
385                 390                 395                 400 


Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
                405                 410         


<210>  17
<211>  2069
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  17
aagacacatg cttctgcaag cttccatgaa ggttgtgcaa aaaagtttca atccagagtt       60

gggttccagc tttctgtagc tgtaagcatt ggtggccaca ccacctcctt acaaagcaac      120

tagaacctgc ggcatacatt ggagagattt ttttaatttt ctggacatga agtaaattta      180

gagtgctttc taatttcagg tagaagacat gtccaccttc tgattatttt tggagaacat      240

tttgattttt ttcatctctc tctccccacc cctaagattg tgcaaaaaaa gcgtaccttg      300

cctaattgaa ataatttcat tggattttga tcagaactga ttatttggtt ttctgtgtga      360

agttttgagg tttcaaactt tccttctgga gaatgccttt tgaaacaatt ttctctagct      420

gcctgatgtc aactgcttag taatcagtgg atattgaaat attcaaaatg tacagagagt      480

gggtagtggt gaatgttttc atgatgttgt acgtccagct ggtgcagggc tccagtaatg      540

aacatggacc agtgaagcga tcatctcagt ccacattgga acgatctgaa cagcagatca      600

gggctgcttc tagtttggag gaactacttc gaattactca ctctgaggac tggaagctgt      660

ggagatgcag gctgaggctc aaaagtttta ccagtatgga ctctcgctca gcatcccatc      720

ggtccactag gtttgcggca actttctatg acattgaaac actaaaagtt atagatgaag      780

aatggcaaag aactcagtgc agccctagag aaacgtgcgt ggaggtggcc agtgagctgg      840

ggaagagtac caacacattc ttcaagcccc cttgtgtgaa cgtgttccga tgtggtggct      900

gttgcaatga agagagcctt atctgtatga acaccagcac ctcgtacatt tccaaacagc      960

tctttgagat atcagtgcct ttgacatcag tacctgaatt agtgcctgtt aaagttgcca     1020

atcatacagg ttgtaagtgc ttgccaacag ccccccgcca tccatactca attatcagaa     1080

gatccatcca gatccctgaa gaagatcgct gttcccattc caagaaactc tgtcctattg     1140

acatgctatg ggatagcaac aaatgtaaat gtgttttgca ggaggaaaat ccacttgctg     1200

gaacagaaga ccactctcat ctccaggaac cagctctctg tgggccacac atgatgtttg     1260

acgaagatcg ttgcgagtgt gtctgtaaaa caccatgtcc caaagatcta atccagcacc     1320

ccaaaaactg cagttgcttt gagtgcaaag aaagtctgga gacctgctgc cagaagcaca     1380

agctatttca cccagacacc tgcagctgtg aggacagatg cccctttcat accagaccat     1440

gtgcaagtgg caaaacagca tgtgcaaagc attgccgctt tccaaaggag aaaagggctg     1500

cccaggggcc ccacagccga aagaatcctt gattcagcgt tccaagttcc ccatccctgt     1560

catttttaac agcatgctgc tttgccaagt tgctgtcact gtttttttcc caggtgttaa     1620

aaaaaaaatc cattttacac agcaccacag tgaatccaga ccaaccttcc attcacacca     1680

gctaaggagt ccctggttca ttgatggatg tcttctagct gcagatgcct ctgcgcacca     1740

aggaatggag aggaggggac ccatgtaatc cttttgttta gttttgtttt tgttttttgg     1800

tgaatgagaa aggtgtgctg gtcatggaat ggcaggtgtc atatgactga ttactcagag     1860

cagatgagga aaactgtagt ctctgagtcc tttgctaatc gcaactcttg tgaattattc     1920

tgattctttt ttatgcagaa tttgattcgt atgatcagta ctgactttct gattactgtc     1980

cagcttatag tcttccagtt taatgaacta ccatctgatg tttcatattt aagtgtattt     2040

aaagaaaata aacaccatta ttcaagcca                                       2069


<210>  18
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Met Tyr Arg Glu Trp Val Val Val Asn Val Phe Met Met Leu Tyr Val 
1               5                   10                  15      


Gln Leu Val Gln Gly Ser Ser Asn Glu His Gly Pro Val Lys Arg Ser 
            20                  25                  30          


Ser Gln Ser Thr Leu Glu Arg Ser Glu Gln Gln Ile Arg Ala Ala Ser 
        35                  40                  45              


Ser Leu Glu Glu Leu Leu Arg Ile Thr His Ser Glu Asp Trp Lys Leu 
    50                  55                  60                  


Trp Arg Cys Arg Leu Arg Leu Lys Ser Phe Thr Ser Met Asp Ser Arg 
65                  70                  75                  80  


Ser Ala Ser His Arg Ser Thr Arg Phe Ala Ala Thr Phe Tyr Asp Ile 
                85                  90                  95      


Glu Thr Leu Lys Val Ile Asp Glu Glu Trp Gln Arg Thr Gln Cys Ser 
            100                 105                 110         


Pro Arg Glu Thr Cys Val Glu Val Ala Ser Glu Leu Gly Lys Ser Thr 
        115                 120                 125             


Asn Thr Phe Phe Lys Pro Pro Cys Val Asn Val Phe Arg Cys Gly Gly 
    130                 135                 140                 


Cys Cys Asn Glu Glu Ser Leu Ile Cys Met Asn Thr Ser Thr Ser Tyr 
145                 150                 155                 160 


Ile Ser Lys Gln Leu Phe Glu Ile Ser Val Pro Leu Thr Ser Val Pro 
                165                 170                 175     


Glu Leu Val Pro Val Lys Val Ala Asn His Thr Gly Cys Lys Cys Leu 
            180                 185                 190         


Pro Thr Ala Pro Arg His Pro Tyr Ser Ile Ile Arg Arg Ser Ile Gln 
        195                 200                 205             


Ile Pro Glu Glu Asp Arg Cys Ser His Ser Lys Lys Leu Cys Pro Ile 
    210                 215                 220                 


Asp Met Leu Trp Asp Ser Asn Lys Cys Lys Cys Val Leu Gln Glu Glu 
225                 230                 235                 240 


Asn Pro Leu Ala Gly Thr Glu Asp His Ser His Leu Gln Glu Pro Ala 
                245                 250                 255     


Leu Cys Gly Pro His Met Met Phe Asp Glu Asp Arg Cys Glu Cys Val 
            260                 265                 270         


Cys Lys Thr Pro Cys Pro Lys Asp Leu Ile Gln His Pro Lys Asn Cys 
        275                 280                 285             


Ser Cys Phe Glu Cys Lys Glu Ser Leu Glu Thr Cys Cys Gln Lys His 
    290                 295                 300                 


Lys Leu Phe His Pro Asp Thr Cys Ser Cys Glu Asp Arg Cys Pro Phe 
305                 310                 315                 320 


His Thr Arg Pro Cys Ala Ser Gly Lys Thr Ala Cys Ala Lys His Cys 
                325                 330                 335     


Arg Phe Pro Lys Glu Lys Arg Ala Ala Gln Gly Pro His Ser Arg Lys 
            340                 345                 350         


Asn Pro 
        


<210>  19
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Gly Ser Ser Gly 
1               


<210>  20
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  20

Ser Ser Gly Gly Gly 
1               5   


<210>  21
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Gly Gly Ser Gly Gly 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Gly Gly Gly Gly Ser 
1               5   


<210>  23
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Ser Ser Gly Gly Gly Ser Gly Gly 
1               5               


<210>  24
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  24

Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10  


<210>  25
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  25

Thr Ser Gly Gly Gly Ser Gly 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  26

Thr Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   


<210>  27
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  27

Ser Ser Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10  


<210>  28
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  28

Ser Ser Gly Gly Gly Ser Gly Gly Ser Ser Gly 
1               5                   10      


<210>  29
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  29

Gly Gly Ser Gly Gly Thr Ser Gly Gly Gly Ser Gly 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  30

Ser Gly Gly Thr Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10          


<210>  31
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  31

Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Ser Gly 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  32

Ser Ser Gly Gly Gly Ser Gly Gly Ser Ser Gly Gly Gly 
1               5                   10              


<210>  33
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  33

Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Ser Gly Gly Gly 
1               5                   10                  15  


<210>  34
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  34

Thr Phe Tyr Asp Ile Glu Thr Leu Lys Val Ile Asp Glu Glu Trp Gln 
1               5                   10                  15      


Arg Thr Gln 
            


<210>  35
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  35

Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu Tyr Pro Asp 
1               5                   10                  15      


Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu Met Arg Cys 
            20                  25                  30          


Gly Gly Cys Cys Asn Asp Glu Gly 
        35                  40  


<210>  36
<211>  173
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  36

Met Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu Tyr His Asn Thr 
1               5                   10                  15      


Gln Ile His Thr Leu Asn Asp Lys Ile Phe Ser Tyr Thr Glu Ser Leu 
            20                  25                  30          


Ala Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys Asn Gly Ala Thr 
        35                  40                  45              


Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys 
    50                  55                  60                  


Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala Tyr Leu Thr Glu 
65                  70                  75                  80  


Ala Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys Thr Pro His Ala 
                85                  90                  95      


Ile Ala Ala Ile Ser Met Ala Asn Ser Ser Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Ser Gly Thr Phe Tyr Asp Ile Glu Thr Leu Lys Val Ile Asp Glu Glu 
        115                 120                 125             


Trp Gln Arg Thr Gln Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe 
    130                 135                 140                 


Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val 
145                 150                 155                 160 


Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly 
                165                 170             


<210>  37
<211>  172
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  37

Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu Tyr His Asn Thr Gln 
1               5                   10                  15      


Ile His Thr Leu Asn Asp Lys Ile Phe Ser Tyr Thr Glu Ser Leu Ala 
            20                  25                  30          


Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys Asn Gly Ala Thr Phe 
        35                  40                  45              


Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys Ala 
    50                  55                  60                  


Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala Tyr Leu Thr Glu Ala 
65                  70                  75                  80  


Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys Thr Pro His Ala Ile 
                85                  90                  95      


Ala Ala Ile Ser Met Ala Asn Ser Ser Gly Gly Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Thr Phe Tyr Asp Ile Glu Thr Leu Lys Val Ile Asp Glu Glu Trp 
        115                 120                 125             


Gln Arg Thr Gln Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln 
    130                 135                 140                 


Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro 
145                 150                 155                 160 


Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly 
                165                 170         


<210>  38
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  38

Gly Gly Ser Gly Gly Thr Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  


