                         SEQUENCE LISTING

<110>  Ichilov Tech Ltd.
       ARBER, Nadir
       SHAPIRA, Shiran
       KAZANOV, Diana
 
<120>  ANTI-CD24 ANTIBODY AND USES THEREOF

<130>  82829

<150>  US 62/866,008
<151>  2019-06-25

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>   ANTI-CD24 light chain amino acid sequence

<400>  1

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Asn Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Arg Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Pro Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ile Tyr Pro Leu Thr Phe Gly Val Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  2
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  2

Arg Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asp Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  3
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  3

Ser Trp Ala Ser Pro Arg Ala Ser 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  4

Tyr Cys Gln Gln Tyr Phe Ile Tyr Pro Leu Thr 
1               5                   10      


<210>  5
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>   ANTI-CD24 heavy chain amino acid sequence

<400>  5

Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Thr Trp His Trp Ile Arg Gln Pro Pro Gly Lys Thr Val Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Gln Tyr Thr Gly Ser Thr Arg Tyr Asn Pro Ala Leu 
    50                  55                  60                  


Arg Gly Arg Leu Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ile Ser Val Thr Ala Ala Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Ala Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala 
        115             


<210>  6
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  6

Ser Gly Tyr Thr Trp His 
1               5       


<210>  7
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  7

Tyr Ile Gln Tyr Thr Gly Ser Thr Arg Tyr Asn Pro Ala Leu Arg Gly 
1               5                   10                  15      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  8

Gly Thr Thr Ala Ser Phe Asp 
1               5           


<210>  9
<211>  6132
<212>  DNA
<213>  Artificial sequence

<220>
<223>   pMAZ-IgH(chSWA11)

<400>  9
gtaccgaatt cacattgatt attgagtagt tattaatagt aatcaattac ggggtcatta       60

gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc      120

tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg      180

ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg      240

gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa      300

tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac      360

atctacggtt agtcatcgct attaccatag tgatgcggtt ttggcagtac atcaatgggc      420

gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga      480

gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat      540

tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctttctggc      600

taactagaga acccactgct tactggcacg tggaaattaa tacgacgtgg ccaccatggg      660

atggagctgt atcatcctct tcttggtagc aacagctaca ggtaaggggt taacagtagc      720

aggcttgagg tctggacata tatatgggtg acaatgacat ccactttgcc tttctctcca      780

caggcgcgca ctccgatgtg caccttcagg agtcaggacc tgacctggtg aaaccttctc      840

agtcactttc actcacctgc actgtcactg gctactccat caccagtggt tatacctggc      900

actggatccg gcagtttcca ggaaacacag tggaatggat gggctacata cagtacactg      960

gttccactag gtacaacccc gctctcagag gtcgactctc tatcagtcga gacacatcca     1020

agaaccagtt cttcctgcag ttgatttctg tgactactgc ggacacaggc acatatttct     1080

gtgcaagggg tactacggcc tcctttgact actggggcca aggcaccact ctcacagtcg     1140

cctcagccgc tagcaccaag ggcccatcgg tcttccccct ggcaccctcc tccaagagca     1200

cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc gaaccggtga     1260

cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg gctgtcctac     1320

agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc agcttgggca     1380

cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg gacaagagag     1440

ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca cctgaactcc     1500

tggggagacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc atgatctccc     1560

ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt     1620

tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg cgggaggagc     1680

agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag gactggctga     1740

atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc atcgagaaaa     1800

ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg cccccatccc     1860

gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctatccca     1920

gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc     1980

ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc gtggacaaga     2040

gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct ctgcacaacc     2100

actacacgca gaagagcctc tccctgtccc cgggtaaatg atctagaagc tcgctgatca     2160

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     2220

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     2280

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     2340

gaggattggg aagacaatag caggcatgct ggggatggcc cgggctctat ggcttctgag     2400

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     2460

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     2520

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     2580

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctctccccc     2640

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     2700

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     2760

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     2820

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     2880

tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     2940

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     3000

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     3060

tcccgcccct aactccgccc agttccgccc attctccgcc cctaggctga ctaatttttt     3120

ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag     3180

gcttttttgg aggcctaggc ttttgcaaaa agctcccccc ccgggaggtc cacaatggtt     3240

gaacaagatg gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat     3300

gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag     3360

gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga actccaggac     3420

gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac     3480

gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc     3540

ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg     3600

ctgcatacgc ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag     3660

cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat     3720

caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgtatgcc cgacggcgag     3780

gatctcgtcg tgactcatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc     3840

ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg     3900

ttggctaccc gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg     3960

ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag     4020

ttcttctgag cgggactctg gggttcgaaa tgaccgacca agcgacgccc aacctgccat     4080

cacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc     4140

gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc     4200

ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     4260

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     4320

cttatcatgt ctgtataccg tcgatctttc cgcttcctcg ctcactgact cgctgcgctc     4380

ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac     4440

agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa     4500

ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca     4560

caaaaatcga cgctcaagtc agagtcgttc gctccaagct gggctgtatg cacgaacccc     4620

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     4680

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     4740

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag     4800

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     4860

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     4920

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     4980

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     5040

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     5100

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     5160

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     5220

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt     5280

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     5340

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     5400

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg     5460

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     5520

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     5580

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     5640

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     5700

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     5760

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     5820

cgctgttgag atccagttcg atgtaaccca ctcgggcacc caactgatct tcagcatctt     5880

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     5940

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa     6000

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     6060

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc agatcgacgg     6120

atcgggagat cg                                                         6132


<210>  10
<211>  6091
<212>  DNA
<213>  Artificial sequence

<220>
<223>   pMAZ-IgL(chSWA11)

<400>  10
gtaccgaatt cacattgatt attgagtagt tattaatagt aatcaattac ggggtcatta       60

gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc      120

tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg      180

ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg      240

gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa      300

tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac      360

atctacggtt agtcatcgct attaccatag tgatgcggtt ttggcagtac atcaatgggc      420

gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga      480

gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat      540

tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctttctggc      600

taactagaga acccactgct tactggcacg tggaaattaa tacgacgtgg ccaccatggg      660

atggagctgt atcatcctct tcttggtagc aacagctaca ggtaaggggt taacagtagc      720

aggcttgagg tctggacata tatatgggtg acaatgacat ccactttgcc tttctctcca      780

caggcgcgca ctccgatatc gtgatgtcac agtctccatc ctccctaaat gtgtcagttg      840

gagagaaggt tactatgagg tgcaggtcca gtcagagcct tttatatagt agcgatcaaa      900

agaactactt gacctggtac cagcagaaac ctgggcagtc tcctaaattg ctgatttcct      960

gggcatccac tagggcatct ggggtccctg atcgcttcac aggcagtgga tctgggacag     1020

atttcactct caccatcagc agtgtgaagg ctgaagacct gggagtttat tactgtcaac     1080

aatattttat ctatccgctc acgttcggtg ttgggaccaa gctggggctg aaacgtacgg     1140

tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa tctggaactg     1200

cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta cagtggaagg     1260

tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag gacagcaagg     1320

acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac gagaaacaca     1380

aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca aagagcttca     1440

acaggggaga gtgttaataa tctagagggc ccgtttttta aaccgctgat cagcctcgac     1500

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     1560

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     1620

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     1680

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag     1740

aaccagctgg ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc     1800

gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc     1860

tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa     1920

tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact     1980

tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt     2040

gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa     2100

ccctatctcg gtctattctt ttgatttata agggattttg gccatttcgg cctattggtt     2160

aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag     2220

ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc     2280

aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa     2340

agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc     2400

ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat     2460

gcagaggccg aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt     2520

ggaggcctag gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat     2580

cagcacgtga tgaaaaagcc tgaactcacc gcgacgtctg tcgagaagtt tctgatcgaa     2640

aagttcgaca gcgtctccga cctgatgcag ctctcggagg gcgaagaatc tcgtgctttc     2700

agcttcgatg taggagggcg tggatatgtc ctgcgggtaa atagctgcgc cgatggtttc     2760

tacaaagatc gttatgttta tcggcacttt gcatcggccg cgctcccgat tccggaagtg     2820

cttgacattg gggaattcag cgagagcctg acctattgca tctcccgccg tgcacagggt     2880

gtcacgttgc aagacctgcc tgaaaccgaa ctgcccgctg ttctgcagcc ggtcgcggag     2940

gccatggatg cgatcgctgc ggccgatctt agccagacga gcgggttcgg cccattcgga     3000

ccgcaaggaa tcggtcaata cactacatgg cgtgatttca tatgcgcgat tgctgatccc     3060

catgtgtatc actggcaaac tgtgatggac gacaccgtca gtgcgtccgt cgcgcaggct     3120

ctcgatgagc tgatgctttg ggccgaggac tgccccgaag tccggcacct cgtgcacgcg     3180

gatttcggct ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg     3240

agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg     3300

tggttggctt gtatggagca gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca     3360

ggatcgccgc ggctccgggc gtatatgctc cgcattggtc ttgaccaact ctatcagagc     3420

ttggttgacg gcaatttcga tgatgcagct tgggcgcagg gtcgatgcga cgcaatcgtc     3480

cgatccggag ccgggactgt cgggcgtaca caaatcgccc gcagaagcgc ggccgtctgg     3540

accgatggct gtgtagaagt actcgccgat agtggaaacc gacgccccag cactcgtccg     3600

agggcaaagg aatagcacgt gctacgagat ttcgattcca ccgccgcctt ctatgaaagg     3660

ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga tcctccagcg cggggatctc     3720

atgctggagt tcttcgccca ccccaacttg tttattgcag cttataatgg ttacaaataa     3780

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt     3840

ttgtccaaac tcatcaatgt atcttatcat gtctgtatac cgtcgacctc tagctagagc     3900

ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca     3960

cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa     4020

ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     4080

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     4140

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     4200

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     4260

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     4320

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     4380

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     4440

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     4500

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     4560

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     4620

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     4680

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     4740

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc     4800

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggttttttt     4860

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     4920

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     4980

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     5040

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     5100

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     5160

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     5220

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     5280

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     5340

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     5400

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     5460

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     5520

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     5580

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     5640

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     5700

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     5760

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     5820

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     5880

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     5940

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     6000

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     6060

cctgacgtca gatcgacgga tcgggagatc g                                    6091


<210>  11
<211>  6132
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pMAZ-IgH(HuSWA11)

<400>  11
gtaccgaatt cacattgatt attgagtagt tattaatagt aatcaattac ggggtcatta       60

gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc      120

tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg      180

ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg      240

gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa      300

tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac      360

atctacggtt agtcatcgct attaccatag tgatgcggtt ttggcagtac atcaatgggc      420

gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga      480

gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat      540

tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctttctggc      600

taactagaga acccactgct tactggcacg tggaaattaa tacgacgtgg ccaccatggg      660

atggagctgt atcatcctct tcttggtagc aacagctaca ggtaaggggt taacagtagc      720

aggcttgagg tctggacata tatatgggtg acaatgacat ccactttgcc tttctctcca      780

caggcgcgca ctcccaggtg caccttcagg agtcaggacc tggcctggtg aaaccttctc      840

agacactttc actcacctgc gctgtctctg gctactccat ctccagtggt tatacctggc      900

actggatccg gcagcctcca ggaaaaacag tggaatggat tggctacata cagtacactg      960

gttccactag gtacaacccc gctctcagag gtcgactcac aatgagtgta gacacatcca     1020

agaaccagtt ctccctgaag ttgatttctg tgactgctgc ggacacaggc gtatatttct     1080

gtgcaagggg tactacggcc tcctttgact actggggcca aggcaccact gtcacagtct     1140

cctcagccgc tagcaccaag ggcccatcgg tcttccccct ggcaccctcc tccaagagca     1200

cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc gaaccggtga     1260

cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg gctgtcctac     1320

agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc agcttgggca     1380

cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg gacaagagag     1440

ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca cctgaactcc     1500

tggggagacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc atgatctccc     1560

ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt     1620

tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg cgggaggagc     1680

agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag gactggctga     1740

atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc atcgagaaaa     1800

ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg cccccatccc     1860

gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctatccca     1920

gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc     1980

ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc gtggacaaga     2040

gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct ctgcacaacc     2100

actacacgca gaagagcctc tccctgtccc cgggtaaatg atctagaagc tcgctgatca     2160

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     2220

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     2280

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     2340

gaggattggg aagacaatag caggcatgct ggggatggcc cgggctctat ggcttctgag     2400

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     2460

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     2520

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     2580

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctctccccc     2640

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     2700

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     2760

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     2820

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     2880

tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     2940

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     3000

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     3060

tcccgcccct aactccgccc agttccgccc attctccgcc cctaggctga ctaatttttt     3120

ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag     3180

gcttttttgg aggcctaggc ttttgcaaaa agctcccccc ccgggaggtc cacaatggtt     3240

gaacaagatg gattgcacgc aggttctccg gccgcttggg tggagaggct attcggctat     3300

gactgggcac aacagacaat cggctgctct gatgccgccg tgttccggct gtcagcgcag     3360

gggcgcccgg ttctttttgt caagaccgac ctgtccggtg ccctgaatga actccaggac     3420

gaggcagcgc ggctatcgtg gctggccacg acgggcgttc cttgcgcagc tgtgctcgac     3480

gttgtcactg aagcgggaag ggactggctg ctattgggcg aagtgccggg gcaggatctc     3540

ctgtcatctc accttgctcc tgccgagaaa gtatccatca tggctgatgc aatgcggcgg     3600

ctgcatacgc ttgatccggc tacctgccca ttcgaccacc aagcgaaaca tcgcatcgag     3660

cgagcacgta ctcggatgga agccggtctt gtcgatcagg atgatctgga cgaagagcat     3720

caggggctcg cgccagccga actgttcgcc aggctcaagg cgcgtatgcc cgacggcgag     3780

gatctcgtcg tgactcatgg cgatgcctgc ttgccgaata tcatggtgga aaatggccgc     3840

ttttctggat tcatcgactg tggccggctg ggtgtggcgg accgctatca ggacatagcg     3900

ttggctaccc gtgatattgc tgaagagctt ggcggcgaat gggctgaccg cttcctcgtg     3960

ctttacggta tcgccgctcc cgattcgcag cgcatcgcct tctatcgcct tcttgacgag     4020

ttcttctgag cgggactctg gggttcgaaa tgaccgacca agcgacgccc aacctgccat     4080

cacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc     4140

gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc     4200

ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     4260

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     4320

cttatcatgt ctgtataccg tcgatctttc cgcttcctcg ctcactgact cgctgcgctc     4380

ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac     4440

agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa     4500

ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca     4560

caaaaatcga cgctcaagtc agagtcgttc gctccaagct gggctgtatg cacgaacccc     4620

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa     4680

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     4740

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag     4800

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     4860

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     4920

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     4980

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     5040

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     5100

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     5160

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     5220

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt     5280

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     5340

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     5400

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg     5460

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     5520

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     5580

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     5640

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     5700

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     5760

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     5820

cgctgttgag atccagttcg atgtaaccca ctcgggcacc caactgatct tcagcatctt     5880

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     5940

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa     6000

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     6060

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc agatcgacgg     6120

atcgggagat cg                                                         6132


<210>  12
<211>  6151
<212>  DNA
<213>  Artificial sequence

<220>
<223>   pMAZ-IgL(HuSWA11)

<400>  12
gtaccgaatt cacattgatt attgagtagt tattaatagt aatcaattac ggggtcatta       60

gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc      120

tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg      180

ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg      240

gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa      300

tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac      360

atctacggtt agtcatcgct attaccatag tgatgcggtt ttggcagtac atcaatgggc      420

gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga      480

gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat      540

tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctttctggc      600

taactagaga acccactgct tactggcacg tggaaattaa tacgacgtgg ccaccatggg      660

atggagctgt atcatcctct tcttggtagc aacagctaca ggtaaggggt taacagtagc      720

aggcttgagg tctggacata tatatgggtg acaatgacat ccactttgcc tttctctcca      780

caggcgcgca ctccgatatc gtgatgggtg acaatgacat ccactttgcc tttctctcca      840

caggcgcgca ctccgatatc gtgatgacac agtctccaga ctccctaaat gtgtcacttg      900

gagagagggc tactatcagg tgcaggtcca gtcagagcct tttatatagt agcgatcaaa      960

agaactactt gacctggtac cagcagaaac ctgggcagcc tcctaaattg ctgatttcct     1020

gggcatccac tagggcatct ggggtccctg atcgcttctc aggcagtgga tctgggacag     1080

atttcactct caccatcagc agtctgcagg ctgaagacgt gggagtttat tactgtcaac     1140

aatattttat ctatccgctc acgttcggtg ttgggaccaa gctggagctg aaacgtacgg     1200

tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa tctggaactg     1260

cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta cagtggaagg     1320

tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag gacagcaagg     1380

acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac gagaaacaca     1440

aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca aagagcttca     1500

acaggggaga gtgttaataa tctagagggc ccgtttttta aaccgctgat cagcctcgac     1560

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     1620

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     1680

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     1740

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag     1800

aaccagctgg ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc     1860

gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc     1920

tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa     1980

tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact     2040

tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt     2100

gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa     2160

ccctatctcg gtctattctt ttgatttata agggattttg gccatttcgg cctattggtt     2220

aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag     2280

ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc     2340

aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa     2400

agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc     2460

ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat     2520

gcagaggccg aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt     2580

ggaggcctag gcttttgcaa aaagctcccg ggagcttgta tatccatttt cggatctgat     2640

cagcacgtga tgaaaaagcc tgaactcacc gcgacgtctg tcgagaagtt tctgatcgaa     2700

aagttcgaca gcgtctccga cctgatgcag ctctcggagg gcgaagaatc tcgtgctttc     2760

agcttcgatg taggagggcg tggatatgtc ctgcgggtaa atagctgcgc cgatggtttc     2820

tacaaagatc gttatgttta tcggcacttt gcatcggccg cgctcccgat tccggaagtg     2880

cttgacattg gggaattcag cgagagcctg acctattgca tctcccgccg tgcacagggt     2940

gtcacgttgc aagacctgcc tgaaaccgaa ctgcccgctg ttctgcagcc ggtcgcggag     3000

gccatggatg cgatcgctgc ggccgatctt agccagacga gcgggttcgg cccattcgga     3060

ccgcaaggaa tcggtcaata cactacatgg cgtgatttca tatgcgcgat tgctgatccc     3120

catgtgtatc actggcaaac tgtgatggac gacaccgtca gtgcgtccgt cgcgcaggct     3180

ctcgatgagc tgatgctttg ggccgaggac tgccccgaag tccggcacct cgtgcacgcg     3240

gatttcggct ccaacaatgt cctgacggac aatggccgca taacagcggt cattgactgg     3300

agcgaggcga tgttcgggga ttcccaatac gaggtcgcca acatcttctt ctggaggccg     3360

tggttggctt gtatggagca gcagacgcgc tacttcgagc ggaggcatcc ggagcttgca     3420

ggatcgccgc ggctccgggc gtatatgctc cgcattggtc ttgaccaact ctatcagagc     3480

ttggttgacg gcaatttcga tgatgcagct tgggcgcagg gtcgatgcga cgcaatcgtc     3540

cgatccggag ccgggactgt cgggcgtaca caaatcgccc gcagaagcgc ggccgtctgg     3600

accgatggct gtgtagaagt actcgccgat agtggaaacc gacgccccag cactcgtccg     3660

agggcaaagg aatagcacgt gctacgagat ttcgattcca ccgccgcctt ctatgaaagg     3720

ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga tcctccagcg cggggatctc     3780

atgctggagt tcttcgccca ccccaacttg tttattgcag cttataatgg ttacaaataa     3840

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt     3900

ttgtccaaac tcatcaatgt atcttatcat gtctgtatac cgtcgacctc tagctagagc     3960

ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca     4020

cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa     4080

ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     4140

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     4200

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     4260

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     4320

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     4380

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     4440

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     4500

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     4560

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     4620

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     4680

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     4740

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     4800

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc     4860

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggttttttt     4920

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     4980

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     5040

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     5100

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     5160

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     5220

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     5280

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     5340

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     5400

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     5460

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     5520

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     5580

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     5640

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     5700

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     5760

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     5820

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     5880

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     5940

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     6000

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     6060

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     6120

cctgacgtca gatcgacgga tcgggagatc g                                    6151


<210>  13
<211>  7049
<212>  DNA
<213>  Artificial sequence

<220>
<223>   pcDNA4-TetO2-CMV-IgL-TetO2-CMV-IgH

<400>  13
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggaacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ccctatcagt gatagagatc      840

tccctatcag tgatagagat cgtcgacgag ctcgtttagt gaaccgtcag atcgcctgga      900

gacgccatcc acgctgtttt gacctccata gaagacaccg ggaccgatcc agcctccgga      960

ctctagcgtt taaacttaag gccaccatgg gatggagctg tatcatcctc ttcttggtag     1020

caacagctac aggtaagggg ttaacagtag caggcttgag gtctggacat atatatgggt     1080

gacaatgaca tccactttgc ctttctctcc acaggcgcgc actccgatat cgtgatgaca     1140

cagtctccag actccctaaa tgtgtcactt ggagagaggg ctactatcag gtgcaggtcc     1200

agtcagagcc ttttatatag tagcgatcaa aagaactact tgacctggta ccagcagaaa     1260

cctgggcagc ctcctaaatt gctgatttcc tgggcatcca ctagggcatc tggggtccct     1320

gatcgcttct caggcagtgg atctgggaca gatttcactc tcaccatcag cagtctgcag     1380

gctgaagacg tgggagttta ttactgtcaa caatatttta tctatccgct cacgttcggt     1440

gttgggacca agctggagct gaaacgtacg gtggctgcac catctgtctt catcttcccg     1500

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc     1560

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc     1620

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg     1680

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag     1740

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttaatg taccgcgggc     1800

ccgtttaaac ccgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt     1860

gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat     1920

aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg     1980

tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg     2040

tgggctctat ggcttctgag gcggaaagaa ccagctgggg ctctaggggg tatccccacg     2100

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     2160

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     2220

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     2280

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccag     2340

atatacgcgt tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt     2400

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg     2460

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac     2520

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt     2580

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa     2640

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta     2700

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg     2760

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg     2820

gagtttgttt tggaaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc     2880

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctctccc     2940

tatcagtgat agagatctcc ctatcagtga tagagatcgt cgacgagctc gtttagtgaa     3000

ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga     3060

ccgatccagc ctccggactc tagcgtttaa acttaagcac gtgccaccat ggagctgtat     3120

catcctcttc ttggtagcaa cagctacagg taaggggtta acagtagcag gcttgaggtc     3180

tggacatata tatgggtgac aatgacatcc actttgcctt tctctccaca ggcgcgcact     3240

cccaggtgca ccttcaggag tcaggacctg gcctggtgaa accttctcag acactttcac     3300

tcacctgcgc tgtctctggc tactccatct ccagtggtta tacctggcac tggatccggc     3360

agcctccagg aaaaacagtg gaatggattg gctacataca gtacactggt tccactaggt     3420

acaaccccgc tctcagaggt cgactcacaa tgagtgtaga cacatccaag aaccagttct     3480

ccctgaagtt gatttctgtg actgctgcgg acacaggcgt atatttctgt gcaaggggta     3540

ctacggcctc ctttgactac tggggccaag gcaccactgt cacagtctcc tcagccgcta     3600

gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca     3660

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     3720

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     3780

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca     3840

tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat     3900

cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt     3960

cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg     4020

tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg     4080

tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca     4140

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt     4200

acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag     4260

ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gaggagatga     4320

ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg     4380

tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg     4440

actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc aggtggcagc     4500

aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga     4560

agagcctctc cctgtccccg ggtaaatgac gtacggatgt gctacgagat ttcgattcca     4620

ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga     4680

tcctccagcg cggggatctc atgctggagt tcttcgccca ccccaacttg tttattgcag     4740

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     4800

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctgtatac     4860

cgtcgacctc tagctagagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt     4920

gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt aaagcctggg     4980

gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt     5040

cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt     5100

tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc     5160

tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg     5220

ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg     5280

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     5340

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     5400

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     5460

ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg     5520

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     5580

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     5640

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     5700

tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc     5760

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     5820

ccgctggtag cggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc     5880

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt     5940

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa     6000

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat     6060

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct     6120

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg     6180

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag     6240

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta     6300

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg     6360

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg     6420

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct     6480

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta     6540

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg     6600

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc     6660

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg     6720

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga     6780

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg     6840

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat     6900

gttgaatact catactcttc ctttttcaat attattgaag catttatcag ggttattgtc     6960

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca     7020

catttccccg aaaagtgcca cctgacgtc                                       7049


<210>  14
<211>  6065
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pET28a-HIS-Hu-IgL

<400>  14
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa     5040

ttttgtttaa ctttaagaag gagatatacc atgggcagca gccatcatca tcatcatcac     5100

agcagcggcc tggtgccgcg cggcagccat atggatatcg tgatgacaca gtctccagac     5160

tccctaaatg tgtcacttgg agagagggct actatcaggt gcaggtccag tcagagcctt     5220

ttatatagta gcgatcaaaa gaactacttg acctggtacc agcagaaacc tgggcagcct     5280

cctaaattgc tgatttcctg ggcatccact agggcatctg gggtccctga tcgcttctca     5340

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaggc tgaagacgtg     5400

ggagtttatt actgtcaaca atattttatc tatccgctca cgttcggtgt tgggaccaag     5460

ctggagctga aacgtacggt ggctgcacca tctgtcttca tcttcccgcc atctgatgag     5520

cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag     5580

gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc     5640

acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa     5700

gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg     5760

cccgtcacaa agagcttcaa caggggagag tgttaataat ctagagggcc cgttttttaa     5820

accgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgga attcgagctc     5880

cgtcgacaag cttgcggccg cactcgagca ccaccaccac caccactgag atccggctgc     5940

taacaaagcc cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactagcata     6000

accccttggg gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc     6060

cggat                                                                 6065


<210>  15
<211>  1976
<212>  DNA
<213>  Artificial sequence

<220>
<223>   pCOMB3X-H(CD24)L(CD24)

<400>  15
atgacacagt ctccagactc cctaaatgtg tcacttggag agagggctac tatcaggtgc       60

aggtccagtc agagcctttt atatagtagc gatcaaaaga actacttgac ctggtaccag      120

cagaaacctg ggcagcctcc taaattgctg atttcctggg catccactag ggcatctggg      180

gtccctgatc gcttctcagg cagtggatct gggacagatt tcactctcac catcagcagt      240

ctgcaggctg aagacgtggg agtttattac tgtcaacaat attttatcta tccgctcacg      300

ttcggtgttg ggaccaagct ggagctgaaa cgtacggtgg ctgcaccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttaatctaga      660

taattaatta ggaggaattt aaaatgaaat acctattgcc tacggcagcc gctggattgt      720

tattactcgc tgcccaacca gccatggccc aggtgcacct tcaggagtca ggacctggcc      780

tggtgaaacc ttctcagaca ctttcactca cctgcgctgt ctctggctac tccatctcca      840

gtggttatac ctggcactgg atccggcagc ctccaggaaa aacagtggaa tggattggct      900

acatacagta cactggttcc actaggtaca accccgctct cagaggtcga ctcacaatga      960

gtgtagacac atccaagaac cagttctccc tgaagttgat ttctgtgact gctgcggaca     1020

caggcgtata tttctgtgca aggggtacta cggcctcctt tgactactgg ggccaaggca     1080

ccactgtcac agtctcctca gccgctagca ccaagggccc atcggtcttc cccctggcac     1140

cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc aaggactact     1200

tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc gtgcacacct     1260

tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg accgtgccct     1320

ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc agcaacacca     1380

aggtggacaa gaaagttgag cccaaatctt gtgacaaaac tagtccggac tacgcttctt     1440

aggagggtgg tggctctgag ggtggcggtt ctgagggtgg cggctctgag ggaggcggtt     1500

ccggtggtgg ctctggttcc ggtgattttg attatgaaaa gatggcaaac gctaataagg     1560

gggctatgac cgaaaatgcc gatgaaaacg tgctacagtc tgacgctaaa ggcaaacttg     1620

attctgtcgc tactgattac ggtgctgcta tcgatggttt cattggtgac gtttccggcc     1680

ttgctaatgg taatggtgct actggtgatt ttgctggctc taattcccaa atggctcaag     1740

tcggtgacgg tgataattca cctttaatga ataatttccg tcaatattta ccttccctcc     1800

ctcaatcggt tgaatgtcgc ccttttgtct ttggcgctgg taaaccatat gaattttcta     1860

ttgattgtga caaaataaac ttattccgtg gtgtctttgc gtttctttta tatgttgcca     1920

cctttatgta tgtattttct acgtttgcta acatactgcg taataaggag tcttaa         1976


<210>  16
<211>  1982
<212>  DNA
<213>  Artificial sequence

<220>
<223>   pCOMB3X-H(CD30)L(CD24)

<400>  16
atgacacagt ctccagactc cctaaatgtg tcacttggag agagggctac tatcaggtgc       60

aggtccagtc agagcctttt atatagtagc gatcaaaaga actacttgac ctggtaccag      120

cagaaacctg ggcagcctcc taaattgctg atttcctggg catccactag ggcatctggg      180

gtccctgatc gcttctcagg cagtggatct gggacagatt tcactctcac catcagcagt      240

ctgcaggctg aagacgtggg agtttattac tgtcaacaat attttatcta tccgctcacg      300

ttcggtgttg ggaccaagct ggagctgaaa cgtacggtgg ctgcaccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat      420

aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt      480

aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc      540

accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc      600

catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg ttaataatct      660

agataattaa ttaggaggaa tttaaaatga aatacctatt gcctacggca gccgctggat      720

tgttattact cgctgcccaa ccagccatgg cccaggtcca actgcagcag ccggggactg      780

aactggtgag gcctggagct tcagtgaagc tgtcctgcaa ggcttctggc ttctccttca      840

ccagttactg gatgaactgg gtgaagcaga ggcctggaca aggccttgag tggattggca      900

tgattcatcc ttccgatagt gaaactaggt taaatcagaa gttcaaggac agggccacat      960

tgactgtaga caaatcctcc agcacagcct acatgcaact cagcagcccg acatctgagg     1020

actctgcggt ctattactgt gcaagtgaga tggattatta ctttgctatg gactactggg     1080

gtcaaggaac ctcagtcacc gtctcctcag ctagcaccaa gggcccatcg gtcttccccc     1140

tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc ctggtcaagg     1200

actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc     1260

acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc gtggtgaccg     1320

tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac aagcccagca     1380

acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactagt ccggactacg     1440

cttcttagga gggtggtggc tctgagggtg gcggttctga gggtggcggc tctgagggag     1500

gcggttccgg tggtggctct ggttccggtg attttgatta tgaaaagatg gcaaacgcta     1560

ataagggggc tatgaccgaa aatgccgatg aaaacgtgct acagtctgac gctaaaggca     1620

aacttgattc tgtcgctact gattacggtg ctgctatcga tggtttcatt ggtgacgttt     1680

ccggccttgc taatggtaat ggtgctactg gtgattttgc tggctctaat tcccaaatgg     1740

ctcaagtcgg tgacggtgat aattcacctt taatgaataa tttccgtcaa tatttacctt     1800

ccctccctca atcggttgaa tgtcgccctt ttgtctttgg cgctggtaaa ccatatgaat     1860

tttctattga ttgtgacaaa ataaacttat tccgtggtgt ctttgcgttt cttttatatg     1920

ttgccacctt tatgtatgta ttttctacgt ttgctaacat actgcgtaat aaggagtctt     1980

aa                                                                    1982


<210>  17
<211>  1979
<212>  DNA
<213>  Artificial sequence

<220>
<223>   pCOMB3X-H(CD24)L(CD30)

<400>  17
gacattgtgc tgacccaatc tccaacttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggttc      120

cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tcttggacag acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctat tactgtcagc aaagtaatga ggatcctcgg      300

acgttcggtg gaggcaccaa actggaaatc aaacgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttaatct      660

agataattaa ttaggaggaa tttaaaatga aatacctatt gcctacggca gccgctggat      720

tgttattact cgctgcccaa ccagccatgg cccaggtgca ccttcaggag tcaggacctg      780

gcctggtgaa accttctcag acactttcac tcacctgcgc tgtctctggc tactccatct      840

ccagtggtta tacctggcac tggatccggc agcctccagg aaaaacagtg gaatggattg      900

gctacataca gtacactggt tccactaggt acaaccccgc tctcagaggt cgactcacaa      960

tgagtgtaga cacatccaag aaccagttct ccctgaagtt gatttctgtg actgctgcgg     1020

acacaggcgt atatttctgt gcaaggggta ctacggcctc ctttgactac tggggccaag     1080

gcaccactgt cacagtctcc tcagccgcta gcaccaaggg cccatcggtc ttccccctgg     1140

caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg gtcaaggact     1200

acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca     1260

ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg gtgaccgtgc     1320

cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag cccagcaaca     1380

ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactagtccg gactacgctt     1440

cttaggaggg tggtggctct gagggtggcg gttctgaggg tggcggctct gagggaggcg     1500

gttccggtgg tggctctggt tccggtgatt ttgattatga aaagatggca aacgctaata     1560

agggggctat gaccgaaaat gccgatgaaa acgtgctaca gtctgacgct aaaggcaaac     1620

ttgattctgt cgctactgat tacggtgctg ctatcgatgg tttcattggt gacgtttccg     1680

gccttgctaa tggtaatggt gctactggtg attttgctgg ctctaattcc caaatggctc     1740

aagtcggtga cggtgataat tcacctttaa tgaataattt ccgtcaatat ttaccttccc     1800

tccctcaatc ggttgaatgt cgcccttttg tctttggcgc tggtaaacca tatgaatttt     1860

ctattgattg tgacaaaata aacttattcc gtggtgtctt tgcgtttctt ttatatgttg     1920

ccacctttat gtatgtattt tctacgtttg ctaacatact gcgtaataag gagtcttaa      1979


<210>  18
<211>  44
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  18
gctaccgtgg cccaggcggc cgatatcgtg atgacacagt ctcc                        44


<210>  19
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  19
attaattatc tagattatta acactctccc ctgttgaagc                             40


<210>  20
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  20
ccaaccagcc atggcccagg tgcaccttca ggagtcagg                              39


<210>  21
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  21
aagcgtagtc cggactagtt ttgtcacaag atttgggctc aactctc                     47


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  22
cgcgattgca gtggcactgg                                                   20


<210>  23
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  23
ggaagatgaa gacagatggt gc                                                22


<210>  24
<211>  68
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  24
ctatcaggtg caggtccagt cmgascstty tctatarcrg cgmccaaara tggtaccagc       60

agaaacct                                                                68


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
actggacctg cacctgatag                                                   20


<210>  26
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  26
cctcctaaat tgctgattkg ggactycmct agggmagggg tccctgatcg cttc             54


<210>  27
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  27
aatcagcaat ttaggagg                                                     18


<210>  28
<211>  7049
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pcDNA4- PCMV-TetO2 -IgL- PCMV-TetO2 -IgH (NS17)

<400>  28
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggaacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ccctatcagt gatagagatc      840

tccctatcag tgatagagat cgtcgacgag ctcgtttagt gaaccgtcag atcgcctgga      900

gacgccatcc acgctgtttt gacctccata gaagacaccg ggaccgatcc agcctccgga      960

ctctagcgtt taaacttaag gccaccatgg gatggagctg tatcatcctc ttcttggtag     1020

caacagctac aggtaagggg ttaacagtag caggcttgag gtctggacat atatatgggt     1080

gacaatgaca tccactttgc ctttctctcc acaggcgcgc actccgatat cgtgatgacc     1140

cagagtcctg acagcctgaa cgtctccttg ggcgaaaggg ccaccattcg ctgcagatcc     1200

tcccagagtc tcctgtacag ctctgatcaa aaaaattacc tcacatggta ccagcagaaa     1260

ccagggcagc cacctaaact gctcatcagc tgggcttctc cccgggcctc cggcgttccc     1320

gatagattta gcgggagcgg gtccggaaca gacttcactc ttaccataag cagtctgcag     1380

gccgaggatg tcggcgtgta ctattgtcag cagtatttta tataccccct gactttcgga     1440

gttggcacca aacttgagct caagcgcact gtagccgctc catcagtgtt catctttccc     1500

cccagcgacg aacagcttaa gtctggcaca gctagcgttg tgtgcctgct caacaacttc     1560

tatcctaggg aggctaaggt gcaatggaag gtggataatg cactccagtc aggcaactcc     1620

caggaaagtg taacggaaca ggacagcaag gactcaacct actctctctc atccactctg     1680

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag     1740

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttaatg taccgcgggc     1800

ccgtttaaac ccgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt     1860

gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat     1920

aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg     1980

tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg     2040

tgggctctat ggcttctgag gcggaaagaa ccagctgggg ctctaggggg tatccccacg     2100

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     2160

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     2220

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     2280

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccag     2340

atatacgcgt tgacattgat tattgactag ttattaatag taatcaatta cggggtcatt     2400

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg     2460

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac     2520

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt     2580

ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa     2640

atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta     2700

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg     2760

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg     2820

gagtttgttt tggaaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc     2880

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctctccc     2940

tatcagtgat agagatctcc ctatcagtga tagagatcgt cgacgagctc gtttagtgaa     3000

ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga     3060

ccgatccagc ctccggactc tagcgtttaa acttaagcac gtgccaccat ggagctgtat     3120

catcctcttc ttggtagcaa cagctacagg taaggggtta acagtagcag gcttgaggtc     3180

tggacatata tatgggtgac aatgacatcc actttgcctt tctctccaca ggcgcgcact     3240

cccaggtgca ccttcaggag tcaggacctg gcctggtgaa accttctcag acactttcac     3300

tcacctgcgc tgtctctggc tactccatct ccagtggtta tacctggcac tggatccggc     3360

agcctccagg aaaaacagtg gaatggattg gctacataca gtacactggt tccactaggt     3420

acaaccccgc tctcagaggt cgactcacaa tgagtgtaga cacatccaag aaccagttct     3480

ccctgaagtt gatttctgtg actgctgcgg acacaggcgt atatttctgt gcaaggggta     3540

ctacggcctc ctttgactac tggggccaag gcaccactgt cacagtctcc tcagccgcta     3600

gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca     3660

cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga     3720

actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac     3780

tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca     3840

tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagcccaaat     3900

cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt     3960

cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg     4020

tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg     4080

tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag tacaacagca     4140

cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt     4200

acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc atctccaaag     4260

ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg gaggagatga     4320

ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg     4380

tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct cccgtgctgg     4440

actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc aggtggcagc     4500

aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga     4560

agagcctctc cctgtccccg ggtaaatgac gtacggatgt gctacgagat ttcgattcca     4620

ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga     4680

tcctccagcg cggggatctc atgctggagt tcttcgccca ccccaacttg tttattgcag     4740

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     4800

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctgtatac     4860

cgtcgacctc tagctagagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt     4920

gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt aaagcctggg     4980

gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt     5040

cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt     5100

tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc     5160

tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg     5220

ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg     5280

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     5340

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     5400

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     5460

ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg     5520

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     5580

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     5640

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     5700

tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc     5760

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     5820

ccgctggtag cggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc     5880

aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt     5940

aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa     6000

aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat     6060

gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct     6120

gactccccgt cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg     6180

caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag     6240

ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta     6300

attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg     6360

ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg     6420

gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct     6480

ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta     6540

tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg     6600

gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc     6660

cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg     6720

gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga     6780

tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg     6840

ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat     6900

gttgaatact catactcttc ctttttcaat attattgaag catttatcag ggttattgtc     6960

tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca     7020

catttccccg aaaagtgcca cctgacgtc                                       7049


<210>  29
<211>  529
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AMINO ACID SEQUENCE OF AN ANTI-CD24 ANTI-CD3 BI-SPECIFIC T CELL 
       ENGAGER (BiTE) COMPRISING A 5 AA LINKER

<400>  29

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val 
        35                  40                  45              


Asp Tyr Asp Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly 
65                  70                  75                  80  


Ile Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln 
            100                 105                 110         


Gln Ser Thr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
145                 150                 155                 160 


Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser 
                165                 170                 175     


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe 
225                 230                 235                 240 


Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
        275                 280                 285             


Ser Gln Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
    290                 295                 300                 


Ser Gly Tyr Thr Trp His Trp Ile Arg Gln Pro Pro Gly Lys Thr Val 
305                 310                 315                 320 


Glu Trp Ile Gly Tyr Ile Gln Tyr Thr Gly Ser Thr Arg Tyr Asn Pro 
                325                 330                 335     


Ala Leu Arg Gly Arg Leu Thr Met Ser Val Asp Thr Ser Lys Asn Gln 
            340                 345                 350         


Phe Ser Leu Lys Leu Ile Ser Val Thr Ala Ala Asp Thr Gly Val Tyr 
        355                 360                 365             


Phe Cys Ala Arg Gly Thr Thr Ala Ser Phe Asp Tyr Trp Gly Gln Gly 
    370                 375                 380                 


Thr Thr Val Thr Val Ser Ser Ala Gly Ser Ala Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
                405                 410                 415     


Ser Pro Asp Ser Leu Asn Val Ser Leu Gly Glu Arg Ala Thr Ile Arg 
            420                 425                 430         


Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asp Gln Lys Asn Tyr 
        435                 440                 445             


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
    450                 455                 460                 


Ser Trp Ala Ser Pro Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
465                 470                 475                 480 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
                485                 490                 495     


Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Tyr Phe Ile Tyr Pro Leu 
            500                 505                 510         


Thr Phe Gly Val Gly Thr Lys Leu Glu Leu Lys His His His His His 
        515                 520                 525             


His 
    


<210>  30
<211>  1602
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NUCLEIC ACID CONSTRUCT ENCODING SEQ ID NO: 29

<400>  30
gaattcatgg agaccggact gaggtggctg ctgctggtcg ccgtgctgaa gggcgtgcag       60

tgtgatatcc aactgaccca gtcccccgcc tctctggctg tgagcctcgg ccagagggct      120

acaatcagct gcaaggctag ccagtccgtg gactacgacg gagactccta tctgaattgg      180

tatcagcaga tccccggcca acctcctaag ctgctgatct acgacgcctc caacctcgtc      240

agcggcatcc ctcctaggtt tagcggctcc ggcagcggca cagacttcac actgaacatc      300

catcccgtcg aaaaggtgga tgccgccaca tatcactgcc agcagagcac cgaggaccct      360

tggaccttcg gcggaggcac aaagctggag atcaaaggcg gaggaggaag cggaggcgga      420

ggatccggag gaggaggatc ccaagtgcag ctccaacaga gcggagctga gctcgtcaga      480

cccggctcca gcgtcaagat tagctgcaag gcctccggct acgccttttc ctcctactgg      540

atgaactggg tgaagcaaag gcccggccaa ggactggagt ggatcggaca gatctggccc      600

ggcgatggag acaccaacta caacggcaag ttcaagggca aggccaccct cacagctgat      660

gagtccagct ccaccgccta catgcagctg tcctctctgg ccagcgaaga tagcgctgtc      720

tacttctgcg ctagaagaga gacaaccacc gtcggaagat actactatgc catggattac      780

tggggccaag gaaccaccgt caccgtgtcc tccggaggag gaggatccca agtgcatctg      840

caagagagcg gacccggcct cgtcaagccc tcccaaaccc tctctctgac atgcgctgtg      900

tccggctatt ccatttccag cggctacaca tggcactgga ttagacagcc tcccggaaag      960

accgtggaat ggatcggcta catccagtac accggaagca ccagatacaa ccccgctctg     1020

agaggaagac tgaccatgtc cgtggacacc agcaaaaacc agttctctct gaagctgatc     1080

tccgtgaccg ctgctgacac cggcgtgtac ttttgcgcta gaggaacaac cgccagcttc     1140

gactattggg gacaaggcac aacagtgacc gtctcctccg ccggatccgc tggcggagga     1200

ggctccggcg gcggcggcag cggcggaggc ggctccgaca tcgtgatgac ccaaagcccc     1260

gactctctga acgtgtctct gggagagagg gctaccatca gatgtaggtc ctcccagtct     1320

ctgctgtact cctccgacca gaaaaactac ctcacatggt accagcagaa gcccggccaa     1380

ccccctaaac tgctgattag ctgggcttcc cccagagcta gcggagtgcc cgatagattt     1440

tccggcagcg gatccggcac cgatttcacc ctcaccatct cctccctcca agccgaagat     1500

gtcggcgtgt actactgcca gcagtatttc atctaccccc tcacattcgg cgtgggcacc     1560

aagctcgaac tcaagcacca tcaccatcac cactgactcg ag                        1602


<210>  31
<211>  534
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AMINO ACID SEQUENCE OF AN ANTI-CD24 ANTI-CD3 BI-SPECIFIC T CELL 
       ENGAGER (BiTE) COMPRISING A 10 AA LINKER

<400>  31

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val 
        35                  40                  45              


Asp Tyr Asp Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly 
65                  70                  75                  80  


Ile Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln 
            100                 105                 110         


Gln Ser Thr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
145                 150                 155                 160 


Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser 
                165                 170                 175     


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys 
        195                 200                 205             


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala 
    210                 215                 220                 


Tyr Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe 
225                 230                 235                 240 


Cys Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met 
                245                 250                 255     


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gln Val His Leu Gln Glu Ser Gly Pro 
        275                 280                 285             


Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Val Ser 
    290                 295                 300                 


Gly Tyr Ser Ile Ser Ser Gly Tyr Thr Trp His Trp Ile Arg Gln Pro 
305                 310                 315                 320 


Pro Gly Lys Thr Val Glu Trp Ile Gly Tyr Ile Gln Tyr Thr Gly Ser 
                325                 330                 335     


Thr Arg Tyr Asn Pro Ala Leu Arg Gly Arg Leu Thr Met Ser Val Asp 
            340                 345                 350         


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ile Ser Val Thr Ala Ala 
        355                 360                 365             


Asp Thr Gly Val Tyr Phe Cys Ala Arg Gly Thr Thr Ala Ser Phe Asp 
    370                 375                 380                 


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Gly Ser Ala 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                405                 410                 415     


Ile Val Met Thr Gln Ser Pro Asp Ser Leu Asn Val Ser Leu Gly Glu 
            420                 425                 430         


Arg Ala Thr Ile Arg Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser Ser 
        435                 440                 445             


Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
    450                 455                 460                 


Pro Lys Leu Leu Ile Ser Trp Ala Ser Pro Arg Ala Ser Gly Val Pro 
465                 470                 475                 480 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                485                 490                 495     


Ser Ser Leu Gln Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Tyr 
            500                 505                 510         


Phe Ile Tyr Pro Leu Thr Phe Gly Val Gly Thr Lys Leu Glu Leu Lys 
        515                 520                 525             


His His His His His His 
    530                 


<210>  32
<211>  1617
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NUCLEIC ACID CONSTRUCT ENCODING SEQ ID NO: 31

<400>  32
gaattcatgg agaccggact gaggtggctg ctgctggtcg ccgtgctgaa gggcgtgcag       60

tgtgatatcc aactgaccca gtcccccgcc tctctggctg tgagcctcgg ccagagggct      120

acaatcagct gcaaggctag ccagtccgtg gactacgacg gagactccta tctgaattgg      180

tatcagcaga tccccggcca acctcctaag ctgctgatct acgacgcctc caacctcgtc      240

agcggcatcc ctcctaggtt tagcggctcc ggcagcggca cagacttcac actgaacatc      300

catcccgtcg aaaaggtgga tgccgccaca tatcactgcc agcagagcac cgaggaccct      360

tggaccttcg gcggaggcac aaagctggag atcaaaggcg gaggaggaag cggaggcgga      420

ggatccggag gaggaggatc ccaagtgcag ctccaacaga gcggagctga gctcgtcaga      480

cccggctcca gcgtcaagat tagctgcaag gcctccggct acgccttttc ctcctactgg      540

atgaactggg tgaagcaaag gcccggccaa ggactggagt ggatcggaca gatctggccc      600

ggcgatggag acaccaacta caacggcaag ttcaagggca aggccaccct cacagctgat      660

gagtccagct ccaccgccta catgcagctg tcctctctgg ccagcgaaga tagcgctgtc      720

tacttctgcg ctagaagaga gacaaccacc gtcggaagat actactatgc catggattac      780

tggggccaag gaaccaccgt caccgtgtcc tccggaggag gaggatccgg cggcggcggc      840

agccaagtgc atctgcaaga gagcggaccc ggcctcgtca agccctccca aaccctctct      900

ctgacatgcg ctgtgtccgg ctattccatt tccagcggct acacatggca ctggattaga      960

cagcctcccg gaaagaccgt ggaatggatc ggctacatcc agtacaccgg aagcaccaga     1020

tacaaccccg ctctgagagg aagactgacc atgtccgtgg acaccagcaa aaaccagttc     1080

tctctgaagc tgatctccgt gaccgctgct gacaccggcg tgtacttttg cgctagagga     1140

acaaccgcca gcttcgacta ttggggacaa ggcacaacag tgaccgtctc ctccgccgga     1200

tccgctggcg gaggaggctc cggcggcggc ggcagcggcg gaggcggctc cgacatcgtg     1260

atgacccaaa gccccgactc tctgaacgtg tctctgggag agagggctac catcagatgt     1320

aggtcctccc agtctctgct gtactcctcc gaccagaaaa actacctcac atggtaccag     1380

cagaagcccg gccaaccccc taaactgctg attagctggg cttcccccag agctagcgga     1440

gtgcccgata gattttccgg cagcggatcc ggcaccgatt tcaccctcac catctcctcc     1500

ctccaagccg aagatgtcgg cgtgtactac tgccagcagt atttcatcta ccccctcaca     1560

ttcggcgtgg gcaccaagct cgaactcaag caccatcacc atcaccactg actcgag        1617


<210>  33
<211>  396
<212>  DNA
<213>  Artificial sequence

<220>
<223>  VL ANTI-CD3 nucleic acid sequence

<400>  33
gaattcatgg agaccggact gaggtggctg ctgctggtcg ccgtgctgaa gggcgtgcag       60

tgtgatatcc aactgaccca gtcccccgcc tctctggctg tgagcctcgg ccagagggct      120

acaatcagct gcaaggctag ccagtccgtg gactacgacg gagactccta tctgaattgg      180

tatcagcaga tccccggcca acctcctaag ctgctgatct acgacgcctc caacctcgtc      240

agcggcatcc ctcctaggtt tagcggctcc ggcagcggca cagacttcac actgaacatc      300

catcccgtcg aaaaggtgga tgccgccaca tatcactgcc agcagagcac cgaggaccct      360

tggaccttcg gcggaggcac aaagctggag atcaaa                                396


<210>  34
<211>  130
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL ANTI-CD3 Amino acid sequence

<400>  34

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val 
        35                  40                  45              


Asp Tyr Asp Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly 
65                  70                  75                  80  


Ile Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Asn Ile His Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln 
            100                 105                 110         


Gln Ser Thr Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys 
    130 


<210>  35
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) sequence

<400>  35

Cys Ala Gly Thr Cys Cys Gly Thr Gly Gly Ala Cys Thr Ala Cys Gly 
1               5                   10                  15      


Ala Cys Gly Gly Ala Gly Ala Cys Thr Cys Cys Thr Ala Thr Cys Thr 
            20                  25                  30          


Gly 
    


<210>  36
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) sequence

<400>  36

Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu 
1               5                   10      


<210>  37
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) sequence

<400>  37
gacgcctcc                                                                9


<210>  38
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) sequence

<400>  38

Asp Ala Ser 
1           


<210>  39
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) sequence

<400>  39
cagcagagca ccgaggaccc ttggacc                                           27


<210>  40
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) sequence

<400>  40

Gln Gln Ser Thr Glu Asp Pro Trp Thr 
1               5                   


<210>  41
<211>  372
<212>  DNA
<213>  Artificial sequence

<220>
<223>  41 VH ANTI-CD3 NA

<400>  41
caagtgcagc tccaacagag cggagctgag ctcgtcagac ccggctccag cgtcaagatt       60

agctgcaagg cctccggcta cgccttttcc tcctactgga tgaactgggt gaagcaaagg      120

cccggccaag gactggagtg gatcggacag atctggcccg gcgatggaga caccaactac      180

aacggcaagt tcaagggcaa ggccaccctc acagctgatg agtccagctc caccgcctac      240

atgcagctgt cctctctggc cagcgaagat agcgctgtct acttctgcgc tagaagagag      300

acaaccaccg tcggaagata ctactatgcc atggattact ggggccaagg aaccaccgtc      360

accgtgtcct cc                                                          372


<210>  42
<211>  124
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH ANTI-CD3 AA

<400>  42

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  43
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  43
ggctacgcct tttcctccta ctgg                                              24


<210>  44
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  44

Gly Tyr Ala Phe Ser Ser Tyr Trp 
1               5               


<210>  45
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  45
atctggcccg gcgatggaga cacc                                              24


<210>  46
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  46

Ile Trp Pro Gly Asp Gly Asp Thr 
1               5               


<210>  47
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  47
gctagaagag agacaaccac cgtcggaaga tactactatg ccatggatta c                51


<210>  48
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  48

Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  49
<211>  339
<212>  DNA
<213>  Artificial sequence

<220>
<223>  VL ANTI-CD24 NA

<400>  49
gatatcgtga tgacccagag tcctgacagc ctgaacgtct ccttgggcga aagggccacc       60

attcgctgca gatcctccca gagtctcctg tacagctctg atcaaaaaaa ttacctcaca      120

tggtaccagc agaaaccagg gcagccacct aaactgctca tcagctgggc ttctccccgg      180

gcctccggcg ttcccgatag atttagcggg agcgggtccg gaacagactt cactcttacc      240

ataagcagtc tgcaggccga ggatgtcggc gtgtactatt gtcagcagta ttttatatac      300

cccctgactt tcggagttgg caccaaactt gagctcaag                             339


<210>  50
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  50
agatcctccc agagtctcct gtacagctct gatcaaaaaa attacctcac a                51


<210>  51
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  51
agctgggctt ctccccgggc ctcc                                              24


<210>  52
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  52
tattgtcagc agtattttat ataccccctg act                                    33


<210>  53
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  VH ANTI-CD24 NA

<400>  53
caggtgcacc ttcaggagtc aggacctggc ctggtgaaac cttctcagac actttcactc       60

acctgcgctg tctctggcta ctccatctcc agtggttata cctggcactg gatccggcag      120

cctccaggaa aaacagtgga atggattggc tacatacagt acactggttc cactaggtac      180

aaccccgctc tcagaggtcg actcacaatg agtgtagaca catccaagaa ccagttctcc      240

ctgaagttga tttctgtgac tgctgcggac acaggcgtat atttctgtgc aaggggtact      300

acggcctcct ttgactactg gggccaaggc accactgtca cagtctcctc agcc            354


<210>  54
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  54
agtggttata cctggcac                                                     18


<210>  55
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  55
tacatacagt acactggttc cactaggtac aaccccgctc tcagaggt                    48


<210>  56
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  56
ggtactacgg cctcctttga ct                                                22


<210>  57
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain V-region of murine SWA11

<400>  57

Asp Val His Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Thr Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Gln Tyr Thr Gly Ser Thr Arg Tyr Asn Pro Ala Leu 
    50                  55                  60                  


Arg Gly Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Ile Ser Val Thr Thr Ala Asp Thr Gly Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Ala Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  58
<211>  351
<212>  DNA
<213>  Artificial sequence

<220>
<223>  heavy chain V-region of murine SWA11

<400>  58
gatgtgcacc ttcaggagtc aggacctgac ctggtgaaac cttctcagtc actttcactc       60

acctgcactg tcactggcta ctccatcacc agtggttata cctggcactg gatccggcag      120

tttccaggaa acacagtgga atggatgggc tacatacagt acactggttc cactaggtac      180

aaccccgctc tcagaggtcg actctctatc agtcgagaca catccaagaa ccagttcttc      240

ctgcagttga tttctgtgac tactgcggac acaggcacat atttctgtgc aaggggtact      300

acggcctcct ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  59
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain V-region of donor sequences from IGVH-28*02 and JH6

<400>  59

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Ile Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 


<210>  60
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain V-region of donor sequences of humanized SWA11

<400>  60

Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Lys Thr Val Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Gln Tyr Thr Gly Ser Thr Arg Tyr Asn Pro Ala Leu 
    50                  55                  60                  


Arg Gly Arg Leu Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ile Ser Val Thr Ala Ala Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Thr Thr Ala Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  61
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  heavy chain V-region of donor sequences of humanized SWA11

<400>  61
caggtgcacc ttcaggagtc aggacctggc ctggtgaaac cttctcagac actttcactc       60

acctgcactg tctctggcta ctccatctcc agtggttata cctggcactg gatccggcag      120

cctccaggaa aaacagtgga atggattggc tacatacagt acactggttc cactaggtac      180

aaccccgctc tcagaggtcg actcacaatg agtgtagaca catccaagaa ccagttctcc      240

ctgaagttga tttctgtgac tgctgcggac acaggcgtat atttctgtgc aaggggtact      300

acggcctcct ttgactactg gggccaaggc accactgtca cagtcgcctc agcc            354


<210>  62
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  D  I  V  M  S  Q  S  P  S  S  L  N  V  S  V  G  E  K  V  T  M  R 
       C R  S  S  Q  S  L  L  Y  S  S  D  Q  K  N  Y  L  T    W  Y  Q  Q
       K  P  G Q  S  P  K  L  L  I  S    W  A  S  T  R  A  S    G  V  P 
       D  R  F  T  G S  G  S  G  T  D  F  T  L  T  I  S  S  V  K  A

<400>  62

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Asn Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Arg Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Gly Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ile Tyr Pro Leu Thr Phe Gly Val Gly Thr Lys Leu Gly Leu 
            100                 105                 110         


Lys 
    


<210>  63
<211>  338
<212>  DNA
<213>  Artificial sequence

<220>
<223>  light chain V-region of murine SWA11

<400>  63
gatatcgtga tgtcacagtc tccatcctcc ctaaatgtgt cagttggaga gaaggttact       60

atgaggtgcg gtccagtcag agccttttat atagtagcga tcaaaagaac tacttgacct      120

ggtaccagca gaaacctggg cagtctccta aattgctgat ttcctgggca tccactaggg      180

catctggggt ccctgatcgc ttcacaggca gtggatctgg gacagatttc actctcacca      240

tcagcagtgt gaaggctgaa gacctgggag tttattactg tcaacaatat tttatctatc      300

cgctcacgtt cggtgttggg accaagctgg ggctgaaa                              338


<210>  64
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  light chain V-region of DONORIGK4-1*01 AND JK2

<400>  64

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  65
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  light chain V-region of humanized SWA11

<400>  65

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Asn Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Arg Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ile Tyr Pro Leu Thr Phe Gly Val Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  66
<211>  338
<212>  DNA
<213>  Artificial sequence

<220>
<223>  light chain V-region of humanized SWA11

<400>  66
gatatcgtga tgacacagtc tccagactcc ctaaatgtgt cacttggaga gagggctact       60

atcaggtgcg gtccagtcag agccttttat atagtagcga tcaaaagaac tacttgacct      120

ggtaccagca gaaacctggg caccctccta aattgctgat ttcctgggca tccactaggg      180

catctggggt ccctgatcgc ttctcaggca gtggatctgg gacagatttc actctcacca      240

tcagcagtct gcaggctgaa gacgtgggag tttattactg tcaacaatat tttatctatc      300

cgctcacgtt cggtgttggg accaagctgg agctgaaa                              338


<210>  67
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  67

Ala Val Arg Thr Cys Cys Ala Gly Thr Cys Ala Gly Ala Val Tyr Lys 
1               5                   10                  15      


Thr Arg Thr Thr Asn Trp Ala Asx Ala Arg Tyr Arg Arg Asn Arg His 
            20                  25                  30          


Asn Met Val Asn Ala Arg Arg Ala Ala Cys Thr Trp Tyr Thr Thr Gly 
        35                  40                  45              


Arg Cys Tyr 
    50      


<210>  68
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  68

Thr Met Cys Lys Lys Asx Gly Cys Ala Thr Tyr Tyr Ser Met Asn Cys 
1               5                   10                  15      


Gly Thr Arg Met Arg Thr Cys Thr 
            20                  


<210>  69
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining regions (CDRs) amino acid sequence

<400>  69

Thr Trp Tyr Thr Gly Cys Met Ala Asn Met Ala Asn Asn Val Tyr His 
1               5                   10                  15      


Asp Tyr Met Asn Tyr His His Tyr Tyr Cys Asn Tyr Asn Asx Thr Ala 
            20                  25                  30          


Cys 
    


<210>  70
<211>  79
<212>  PRT
<213>  Artificial sequence

<220>
<223>  example of the CD24 amino acid sequence  (partial P25063)

<400>  70

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly 
            20                  25                  30          


Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro 
        35                  40                  45              


Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser 
    50                  55                  60                  


Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr 
65                  70                  75                  


<210>  71
<211>  76
<212>  PRT
<213>  Artificial sequence

<220>
<223>  example of the CD24 amino acid sequence  (partial Q3ZC86)

<400>  71

Met Gly Arg Ala Ile Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Thr Tyr Ser Asn Gln Thr Thr Val Val 
            20                  25                  30          


Thr Pro Ser Asn Ser Ser Gln Thr Thr Ser Pro Ala Pro His Pro Ala 
        35                  40                  45              


Asn Ala Thr Thr Lys Ala Ser Asp Gly Thr Leu Gln Ser Thr Ala Ser 
    50                  55                  60                  


Leu Phe Val Ile Ser Val Ser Leu Leu His Leu Tyr 
65                  70                  75      


<210>  72
<211>  77
<212>  PRT
<213>  Artificial sequence

<220>
<223>  example of the CD24 amino acid sequence  (partial W5PN54)

<400>  72

Met Gly Arg Ala Ile Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Thr Tyr Ser Asn Gln Thr Thr Val Val 
            20                  25                  30          


Thr Pro Ser Ser Asn Ser Ser Gln Thr Thr Ser Pro Ala Pro His Pro 
        35                  40                  45              


Ala Asn Ala Thr Thr Lys Ala Ser Asp Gly Thr Leu Gln Ser Thr Ala 
    50                  55                  60                  


Ser Leu Phe Val Ile Ser Val Ser Leu Leu His Leu Tyr 
65                  70                  75          


<210>  73
<211>  77
<212>  PRT
<213>  Artificial sequence

<220>
<223>  example of the CD24 amino acid sequence  (partial A0A0D95AJ1)

<400>  73

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Met Gln Ile Tyr Ser Asn Glu Thr Thr Val Val 
            20                  25                  30          


Thr Val Ser Ser Asn Ser Ser Gln Ser Thr Ser Thr Ala Pro Asn Pro 
        35                  40                  45              


Ala Asn Ala Thr Ile Lys Ala Val Gly Gly Ala Leu Gln Ser Thr Ala 
    50                  55                  60                  


Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr 
65                  70                  75          


<210>  74
<211>  77
<212>  PRT
<213>  Artificial sequence

<220>
<223>  example of the CD24 amino acid sequence  (partial K7GMK8)

<400>  74

Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Trp Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Asn Gln Thr Thr Leu Val 
            20                  25                  30          


Thr Val Ser Ser Asn Ser Thr His Ser Thr Ser Ala Ala Pro Asn Pro 
        35                  40                  45              


Ala Asn Ala Thr Thr Lys Ala Ser Asp Gly Ala Leu Gln Ser Thr Ala 
    50                  55                  60                  


Ser Leu Phe Val Leu Ser Val Ser Leu Leu His Leu Tyr 
65                  70                  75          


