                         SEQUENCE LISTING

<110>  GUANGDONG TCRCURE BIOPHARMA TECHNOLOGY CO., LTD. and 
       TCRCURE BIOPHARMA CORP.
 
<120>  ANTI-ALPP CAR-T CELL THERAPY

<130>  49159-0004WO1

<140>  PCT/US2020/039084
<141>  2020-06-23

<150>  62/865,244
<151>  2019-06-23

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  1

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Glu Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Thr Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Phe Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His His Tyr Val Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  A03 CAR VH

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Glu Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Val Thr Met Leu Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Ser Leu Val Thr Val Ser Ser 
        115                 120     


<210>  4
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  A03 CAR VL

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His His Tyr Val Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  5
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  A04 CAR VH

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Glu Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Asp Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  A04 CAR VL

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  7
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  A05 CAR VH

<400>  7

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Glu Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Asp Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  A05 CAR VL

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  9
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  A06 CAR VH

<400>  9

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Glu Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Asp Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  A06 CAR VL

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  A07 CAR VH

<400>  11

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Glu Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Asp Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  12
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  A07 CAR VL

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  A08 CAR VH

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Glu Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Ile 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Asp Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  A08 CAR VL

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Anti-PD-1 scFv VH

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Met Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Asp Tyr Asn Tyr Asp Gly Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Anti-PD-1 scFv VL

<400>  16

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Phe Asn Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Phe Leu Ala Ser Asn Leu Ala Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Gly Arg 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110 


<210>  17
<211>  1506
<212>  DNA
<213>  Artificial

<220>
<223>  A02 CAR

<400>  17
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tgcagctgaa agagtctggc cctggactgg tggccccaag ccagtctctg      120

agcatcacct gtaccgtgtc cggcttcagc ctgacaagct atggcgtgtc ctgggtccga      180

cagcctccta gaaaaggcct ggaatggctg ggcgtgatct gggaggatgg cagcaccaat      240

taccacagcg ccctgatcag cagactgtcc atcaacaagg acaacagcaa gagccaggtg      300

ttcctgaagc tgaacagcct gcagaccgac gacaccgcca cctactattg tgccaagcct      360

cactacggca gcagctacgt gggcgctatg gaatattggg gccagggcac aagcgtgacc      420

gtgtctagcg aaaagggaag aagtggcggc ggaggatctg gcggaggtgg aagcggaggc      480

ggtggatctg atatccagat gacacagagc cccgccagcc tgactgcttc tgtgggagag      540

acagtgacca tcacatgccg ggccagcgag aacatctact cctacgtggc ctggtatcag      600

caaaagcagg gcaagagccc tcagttcctg gtgtacaacg ccaagtctct ggccgagggc      660

gtgccaagca gattttctgg ctctggcagc ggcacccagt tctccctgaa gatcaattcc      720

ctgcagccag aggacttcgg caactactac tgccagcacc actatgtgtc tccctggacc      780

tttggcggag gcaccaagct ggaaatcaaa cggtacgtaa cgacgacacc agcaccccgc      840

cctcccacac cagcgcctac gatcgccagc caaccattgt cactgcggcc tgaggcttgc      900

agaccagctg ccggtggagc cgtccacaca cgcggacttg actttgcttg cgacatctac      960

atctgggctc ctctcgcagg cacctgcggt gtactgcttc tctcactggt cattacactc     1020

tattgccgat ttagtgtggt caaacgaggc cgaaaaaaac tcctttatat cttcaaacag     1080

cctttcatga gacctgtgca aacaacccag gaagaagacg gttgctcttg ccgctttccc     1140

gaagaagaag aaggaggttg cgaactgaga gttaaattct ctaggtctgc cgacgcccct     1200

gcctaccagc agggccagaa ccagctgtat aacgaactga acctcggacg acgagaagaa     1260

tatgatgtac tcgataaaag acgcggaagg gaccccgaaa tgggcgggaa gccccggagg     1320

aagaacccac aggagggtct gtataatgaa ctccagaaag acaaaatggc cgaagcatat     1380

tcagaaattg gcatgaaagg ggaacgaagg cggggtaaag ggcacgatgg cctttatcag     1440

ggacttagca cagccacaaa agacacttat gacgctctgc acatgcaagc cctcccccca     1500

cggtag                                                                1506


<210>  18
<211>  501
<212>  PRT
<213>  Artificial

<220>
<223>  A02 CAR

<400>  18

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Arg 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Leu Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Lys Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Thr Ala 
                165                 170                 175     


Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln 
        195                 200                 205             


Phe Leu Val Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Tyr 
            260                 265                 270         


Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys 
            340                 345                 350         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        355                 360                 365             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    370                 375                 380                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
385                 390                 395                 400 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                405                 410                 415     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            420                 425                 430         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        435                 440                 445             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    450                 455                 460                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
465                 470                 475                 480 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                485                 490                 495     


Ala Leu Pro Pro Arg 
            500     


<210>  19
<211>  1506
<212>  DNA
<213>  Artificial

<220>
<223>  A03 CAR

<400>  19
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tccagctgca agagtctggc cctggactcg tcagacctag ccagacactg      120

agcctgacct gtaccgtgtc cggcttcacc tttaccagct acggcgtgtc ctgggtccga      180

cagcctcctg gaagaggact ggaatggatc ggcgtgatct gggaggacgg cagcaccaat      240

tatcacagcg ccctgatcag cagagtgacc atgctggtgg acacctccaa gaaccagttc      300

agcctgagac tgagcagcgt gacagccgcc gatacagccg tgtactactg tgccagacct      360

cactacggca gcagctatgt gggcgccatg gaatattggg gccagggctc tctggtcacc      420

gtgtctagcg aaaagggaag aagtggcggc ggaggatctg gcggaggtgg aagcggaggc      480

ggtggatctg atatccagat gacacagagc cccagcagcc tgtctgcctc tgtgggagac      540

agagtgacaa tcacctgtcg ggccagcgag aacatctaca gctacgtggc ctggtatcag      600

caaaagcccg gcaaggcccc taagctgctg atctacaatg ccaagtctct ggccgagggc      660

gtgcccagca gattttctgg ttctggcagc ggcaccgact ttacctttac aatcagctcc      720

ctgcagcctg aggatatcgc cacctactac tgccagcacc actacgtgtc cccatggaca      780

tttggccagg gcaccaaggt ggaaatcaag cggtacgtaa cgacgacacc agcaccccgc      840

cctcccacac cagcgcctac gatcgccagc caaccattgt cactgcggcc tgaggcttgc      900

agaccagctg ccggtggagc cgtccacaca cgcggacttg actttgcttg cgacatctac      960

atctgggctc ctctcgcagg cacctgcggt gtactgcttc tctcactggt cattacactc     1020

tattgccgat ttagtgtggt caaacgaggc cgaaaaaaac tcctttatat cttcaaacag     1080

cctttcatga gacctgtgca aacaacccag gaagaagacg gttgctcttg ccgctttccc     1140

gaagaagaag aaggaggttg cgaactgaga gttaaattct ctaggtctgc cgacgcccct     1200

gcctaccagc agggccagaa ccagctgtat aacgaactga acctcggacg acgagaagaa     1260

tatgatgtac tcgataaaag acgcggaagg gaccccgaaa tgggcgggaa gccccggagg     1320

aagaacccac aggagggtct gtataatgaa ctccagaaag acaaaatggc cgaagcatat     1380

tcagaaattg gcatgaaagg ggaacgaagg cggggtaaag ggcacgatgg cctttatcag     1440

ggacttagca cagccacaaa agacacttat gacgctctgc acatgcaagc cctcccccca     1500

cggtag                                                                1506


<210>  20
<211>  501
<212>  PRT
<213>  Artificial

<220>
<223>  A03 CAR

<400>  20

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Thr Phe Thr Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Arg Gly Leu Glu Trp Ile Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Val Thr Met Leu Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Tyr 
            260                 265                 270         


Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys 
            340                 345                 350         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        355                 360                 365             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    370                 375                 380                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
385                 390                 395                 400 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                405                 410                 415     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            420                 425                 430         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        435                 440                 445             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    450                 455                 460                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
465                 470                 475                 480 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                485                 490                 495     


Ala Leu Pro Pro Arg 
            500     


<210>  21
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  A04 CAR

<400>  21
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tccagctgca agagtctggc cctggactgg ttgccccaag ccaaacactg      120

agcctgacct gtaccgtgtc cggctttagc ctgacaagct acggcgtgtc ctggatcaga      180

cagcctcctg gcaaaggcct ggaatggatc ggagtgatct gggaggacgg cagcaccaat      240

taccacagcg ccctgatcag ccgggtgtcc atctctgtgg ataccagcaa gagccagttc      300

agcctgaagc tgtctagcgt ggacgccgcc gatacagccg tgtactattg tgccagacct      360

cactacggca gcagctacgt gggcgctatg gaatattggg gccagggcac caccgtgacc      420

gtgtctagtg aaaagggaag atccggcgga ggcggatctg gtggcggagg tagtggcggc      480

ggaggatctg acattcagat gacacagagc cccagcagcc tgtctgcctc tgtgggagac      540

agagtgacca tcacctgtcg ggccagcgag aacatctact cctacgtggc ctggtatcag      600

caaaagcccg gcaaggcccc taagttcctg atctacaacg ccaagtctct ggccgagggc      660

gtgccaagca gattttctgg ctctggcagc ggcaccgact tcaccctgac aatatctagc      720

ctccagcctg aggacttcgc caactactac tgccagcacc actatgtgtc tccctggacc      780

tttggccagg gaacaaaggt ggaaatcaag tacgtaacga cgacaccagc accccgccct      840

cccacaccag cgcctacgat cgccagccaa ccattgtcac tgcggcctga ggcttgcaga      900

ccagctgccg gtggagccgt ccacacacgc ggacttgact ttgcttgcga catctacatc      960

tgggctcctc tcgcaggcac ctgcggtgta ctgcttctct cactggtcat tacactctat     1020

tgccgattta gtgtggtcaa acgaggccga aaaaaactcc tttatatctt caaacagcct     1080

ttcatgagac ctgtgcaaac aacccaggaa gaagacggtt gctcttgccg ctttcccgaa     1140

gaagaagaag gaggttgcga actgagagtt aaattctcta ggtctgccga cgcccctgcc     1200

taccagcagg gccagaacca gctgtataac gaactgaacc tcggacgacg agaagaatat     1260

gatgtactcg ataaaagacg cggaagggac cccgaaatgg gcgggaagcc ccggaggaag     1320

aacccacagg agggtctgta taatgaactc cagaaagaca aaatggccga agcatattca     1380

gaaattggca tgaaagggga acgaaggcgg ggtaaagggc acgatggcct ttatcaggga     1440

cttagcacag ccacaaaaga cacttatgac gctctgcaca tgcaagccct ccccccacgg     1500

tag                                                                   1503


<210>  22
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  A04 CAR

<400>  22

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Val Ser Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Asp Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Phe Leu Ile Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Tyr Val 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  23
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  A05 CAR

<400>  23
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tgcagctgaa agagtctggc cctggactgg tggccccaag ccaaacactg      120

agcctgacct gtaccgtgtc cggctttagc ctgacaagct acggcgtgtc ctggatcaga      180

cagcctcctg gcaaaggcct ggaatggatc ggagtgatct gggaggacgg cagcaccaat      240

taccacagcg ccctgatcag ccgggtgtcc atctctgtgg ataccagcaa gagccagttc      300

agcctgaagc tgtctagcgt ggacgccgcc gatacagccg tgtactattg tgccagacct      360

cactacggca gcagctacgt gggcgctatg gaatattggg gccagggcac caccgtgacc      420

gtgtctagtg aaaagggaag atccggcgga ggcggatctg gtggcggagg tagtggcggc      480

ggaggatctg acattcagat gacacagagc cccagcagcc tgtctgcctc tgtgggagac      540

agagtgacca tcacctgtcg ggccagcgag aacatctact cctacgtggc ctggtatcag      600

caaaagcccg gcaaggcccc taagttcctg atctacaacg ccaagtctct ggccgagggc      660

gtgccaagca gattttctgg ctctggcagc ggcaccgact tcaccctgac aatatctagc      720

ctccagcctg aggacttcgc caactactac tgccagcacc actatgtgtc tccctggacc      780

tttggccagg gaacaaaggt ggaaatcaag tacgtaacga cgacaccagc accccgccct      840

cccacaccag cgcctacgat cgccagccaa ccattgtcac tgcggcctga ggcttgcaga      900

ccagctgccg gtggagccgt ccacacacgc ggacttgact ttgcttgcga catctacatc      960

tgggctcctc tcgcaggcac ctgcggtgta ctgcttctct cactggtcat tacactctat     1020

tgccgattta gtgtggtcaa acgaggccga aaaaaactcc tttatatctt caaacagcct     1080

ttcatgagac ctgtgcaaac aacccaggaa gaagacggtt gctcttgccg ctttcccgaa     1140

gaagaagaag gaggttgcga actgagagtt aaattctcta ggtctgccga cgcccctgcc     1200

taccagcagg gccagaacca gctgtataac gaactgaacc tcggacgacg agaagaatat     1260

gatgtactcg ataaaagacg cggaagggac cccgaaatgg gcgggaagcc ccggaggaag     1320

aacccacagg agggtctgta taatgaactc cagaaagaca aaatggccga agcatattca     1380

gaaattggca tgaaagggga acgaaggcgg ggtaaagggc acgatggcct ttatcaggga     1440

cttagcacag ccacaaaaga cacttatgac gctctgcaca tgcaagccct ccccccacgg     1500

tag                                                                   1503


<210>  24
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  A05 CAR

<400>  24

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Val Ser Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Asp Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Phe Leu Ile Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Tyr Val 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  25
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  A06 CAR

<400>  25
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tgcagctgaa agagtctggc cctggactgg tggccccaag ccaaacactg      120

agcctgacct gtaccgtgtc cggctttagc ctgacaagct acggcgtgtc ctggatcaga      180

cagcctcctg gcaaaggcct ggaatggatc ggagtgatct gggaggacgg cagcaccaat      240

taccacagcg ccctgatcag ccgggtgtcc atctctgtgg ataccagcaa gagccagttc      300

agcctgaagc tgtctagcgt ggacgccgcc gatacagccg tgtactattg tgccaagcct      360

cactacggca gcagctacgt gggcgctatg gaatattggg gccagggcac caccgtgacc      420

gtgtctagtg aaaagggaag atccggcgga ggcggatctg gtggcggagg tagtggcggc      480

ggaggatctg acattcagat gacacagagc cccagcagcc tgtctgcctc tgtgggagac      540

agagtgacca tcacctgtcg ggccagcgag aacatctact cctacgtggc ctggtatcag      600

caaaagcccg gcaaggcccc taagctgctg atctacaatg ccaagtctct ggccgagggc      660

gtgcccagca gattttctgg ttctggcagc ggcaccgact tcaccctgac aatatctagc      720

ctccagcctg aggacttcgc caactactac tgccagcacc actatgtgtc tccctggacc      780

tttggccagg gaacaaaggt ggaaatcaag tacgtaacga cgacaccagc accccgccct      840

cccacaccag cgcctacgat cgccagccaa ccattgtcac tgcggcctga ggcttgcaga      900

ccagctgccg gtggagccgt ccacacacgc ggacttgact ttgcttgcga catctacatc      960

tgggctcctc tcgcaggcac ctgcggtgta ctgcttctct cactggtcat tacactctat     1020

tgccgattta gtgtggtcaa acgaggccga aaaaaactcc tttatatctt caaacagcct     1080

ttcatgagac ctgtgcaaac aacccaggaa gaagacggtt gctcttgccg ctttcccgaa     1140

gaagaagaag gaggttgcga actgagagtt aaattctcta ggtctgccga cgcccctgcc     1200

taccagcagg gccagaacca gctgtataac gaactgaacc tcggacgacg agaagaatat     1260

gatgtactcg ataaaagacg cggaagggac cccgaaatgg gcgggaagcc ccggaggaag     1320

aacccacagg agggtctgta taatgaactc cagaaagaca aaatggccga agcatattca     1380

gaaattggca tgaaagggga acgaaggcgg ggtaaagggc acgatggcct ttatcaggga     1440

cttagcacag ccacaaaaga cacttatgac gctctgcaca tgcaagccct ccccccacgg     1500

tag                                                                   1503


<210>  26
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  A06 CAR

<400>  26

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Val Ser Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Asp Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Tyr Val 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  27
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  A07 CAR

<400>  27
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tgcagctgaa agagtctggc cctggactgg tggccccaag ccaaacactg      120

agcctgacct gtaccgtgtc cggctttagc ctgacaagct acggcgtgtc ctggatcaga      180

cagcctcctg gcaaaggcct ggaatggatc ggagtgatct gggaggacgg cagcaccaat      240

taccacagcg ccctgatcag ccgggtgtcc atctctgtgg ataccagcaa gagccagttc      300

agcctgaagc tgtctagcgt ggacgccgcc gatacagccg tgtactattg tgccaagcct      360

cactacggca gcagctacgt gggcgctatg gaatattggg gccagggcac caccgtgacc      420

gtgtctagtg aaaagggaag atccggcgga ggcggatctg gtggcggagg tagtggcggc      480

ggaggatctg acattcagat gacacagagc cccagcagcc tgtctgcctc tgtgggagac      540

agagtgacca tcacctgtcg ggccagcgag aacatctact cctacgtggc ctggtatcag      600

caaaagcccg gcaaggcccc taagttcctg atctacaacg ccaagtctct ggccgagggc      660

gtgccaagca gattttctgg ctctggcagc ggcaccgact tcaccctgac catatctagc      720

ctgcagccag aggacttcgc caactactac tgccagcacc actatgtgtc tccctggacc      780

tttggccagg gaacaaaggt ggaaatcaag tacgtaacga cgacaccagc accccgccct      840

cccacaccag cgcctacgat cgccagccaa ccattgtcac tgcggcctga ggcttgcaga      900

ccagctgccg gtggagccgt ccacacacgc ggacttgact ttgcttgcga catctacatc      960

tgggctcctc tcgcaggcac ctgcggtgta ctgcttctct cactggtcat tacactctat     1020

tgccgattta gtgtggtcaa acgaggccga aaaaaactcc tttatatctt caaacagcct     1080

ttcatgagac ctgtgcaaac aacccaggaa gaagacggtt gctcttgccg ctttcccgaa     1140

gaagaagaag gaggttgcga actgagagtt aaattctcta ggtctgccga cgcccctgcc     1200

taccagcagg gccagaacca gctgtataac gaactgaacc tcggacgacg agaagaatat     1260

gatgtactcg ataaaagacg cggaagggac cccgaaatgg gcgggaagcc ccggaggaag     1320

aacccacagg agggtctgta taatgaactc cagaaagaca aaatggccga agcatattca     1380

gaaattggca tgaaagggga acgaaggcgg ggtaaagggc acgatggcct ttatcaggga     1440

cttagcacag ccacaaaaga cacttatgac gctctgcaca tgcaagccct ccccccacgg     1500

tag                                                                   1503


<210>  28
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  A07 CAR

<400>  28

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Val Ser Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Asp Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Phe Leu Ile Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Tyr Val 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  29
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  A08 CAR

<400>  29
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tccagctgca agagtctggc cctggactgg tcaagcctag ccagacactg      120

agcctgacct gtaccgtgtc cggctttagc ctgacaagct acggcgtgtc ctggatcaga      180

cagcctcctg gcaaaggcct ggaatggatc ggagtgatct gggaggacgg cagcaccaat      240

taccacagcg ccctgatcag ccgggtgtcc atctctgtgg ataccagcaa gagccagttc      300

agcctgaagc tgtctagcgt ggacgccgcc gatacagccg tgtactattg tgccagacct      360

cactacggca gcagctacgt gggcgctatg gaatattggg gccagggcac caccgtgacc      420

gtgtctagtg aaaagggaag atccggcgga ggcggatctg gtggcggagg tagtggcggc      480

ggaggatctg acattcagat gacacagagc cccagcagcc tgtctgcctc tgtgggagac      540

agagtgacca tcacctgtcg ggccagcgag aacatctact cctacgtggc ctggtatcag      600

caaaagcccg gcaaggcccc taagttcctg atctacaacg ccaagtctct ggccgagggc      660

gtgccaagca gattttctgg ctctggcagc ggcaccgact tcaccctgac catatctagc      720

ctgcagcctg aggacttcgc caactactac tgccagcacc actatgtgtc tccctggacc      780

tttggccagg gaacaaaggt ggaaatcaag tacgtaacga cgacaccagc accccgccct      840

cccacaccag cgcctacgat cgccagccaa ccattgtcac tgcggcctga ggcttgcaga      900

ccagctgccg gtggagccgt ccacacacgc ggacttgact ttgcttgcga catctacatc      960

tgggctcctc tcgcaggcac ctgcggtgta ctgcttctct cactggtcat tacactctat     1020

tgccgattta gtgtggtcaa acgaggccga aaaaaactcc tttatatctt caaacagcct     1080

ttcatgagac ctgtgcaaac aacccaggaa gaagacggtt gctcttgccg ctttcccgaa     1140

gaagaagaag gaggttgcga actgagagtt aaattctcta ggtctgccga cgcccctgcc     1200

taccagcagg gccagaacca gctgtataac gaactgaacc tcggacgacg agaagaatat     1260

gatgtactcg ataaaagacg cggaagggac cccgaaatgg gcgggaagcc ccggaggaag     1320

aacccacagg agggtctgta taatgaactc cagaaagaca aaatggccga agcatattca     1380

gaaattggca tgaaagggga acgaaggcgg ggtaaagggc acgatggcct ttatcaggga     1440

cttagcacag ccacaaaaga cacttatgac gctctgcaca tgcaagccct ccccccacgg     1500

tag                                                                   1503


<210>  30
<211>  500
<212>  PRT
<213>  Artificial

<220>
<223>  A08 CAR

<400>  30

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Val Ser Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Asp Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Phe Leu Ile Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Tyr Val 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  31
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Anti-PD-L1 scFv VH

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  32
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Anti-PD-L1 scFv VL

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  33
<211>  2382
<212>  DNA
<213>  Artificial

<220>
<223>  A02P03

<400>  33
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tgcagctgaa agagtctggc cctggactgg tggccccaag ccagtctctg      120

agcatcacct gtaccgtgtc cggcttcagc ctgacaagct atggcgtgtc ctgggtccga      180

cagcctccta gaaaaggcct ggaatggctg ggcgtgatct gggaggatgg cagcaccaat      240

taccacagcg ccctgatcag cagactgtcc atcaacaagg acaacagcaa gagccaggtg      300

ttcctgaagc tgaacagcct gcagaccgac gacaccgcca cctactattg tgccaagcct      360

cactacggca gcagctacgt gggcgctatg gaatattggg gccagggcac aagcgtgacc      420

gtgtctagcg aaaagggaag aagtggcggc ggaggatctg gcggaggtgg aagcggaggc      480

ggtggatctg atatccagat gacacagagc cccgccagcc tgactgcttc tgtgggagag      540

acagtgacca tcacatgccg ggccagcgag aacatctact cctacgtggc ctggtatcag      600

caaaagcagg gcaagagccc tcagttcctg gtgtacaacg ccaagtctct ggccgagggc      660

gtgccaagca gattttctgg ctctggcagc ggcacccagt tctccctgaa gatcaattcc      720

ctgcagccag aggacttcgg caactactac tgccagcacc actatgtgtc tccctggacc      780

tttggcggag gcaccaagct ggaaatcaaa cggtacgtaa cgacgacacc agcaccccgc      840

cctcccacac cagcgcctac gatcgccagc caaccattgt cactgcggcc tgaggcttgc      900

agaccagctg ccggtggagc cgtccacaca cgcggacttg actttgcttg cgacatctac      960

atctgggctc ctctcgcagg cacctgcggt gtactgcttc tctcactggt cattacactc     1020

tattgccgat ttagtgtggt caaacgaggc cgaaaaaaac tcctttatat cttcaaacag     1080

cctttcatga gacctgtgca aacaacccag gaagaagacg gttgctcttg ccgctttccc     1140

gaagaagaag aaggaggttg cgaactgaga gttaaattct ctaggtctgc cgacgcccct     1200

gcctaccagc agggccagaa ccagctgtat aacgaactga acctcggacg acgagaagaa     1260

tatgatgtac tcgataaaag acgcggaagg gaccccgaaa tgggcgggaa gccccggagg     1320

aagaacccac aggagggtct gtataatgaa ctccagaaag acaaaatggc cgaagcatat     1380

tcagaaattg gcatgaaagg ggaacgaagg cggggtaaag ggcacgatgg cctttatcag     1440

ggacttagca cagccacaaa agacacttat gacgctctgc acatgcaagc cctcccccca     1500

cgggtcgaca gagccaagcg gggctctggc gagggcagag gctctctgct gacctgcgga     1560

gatgtggaag aaaatcccgg ccctatgtac agaatgcagc tgttgtcttg tattgccctt     1620

tctctcgccc tcgtaacaaa ttcacaagtc cagcttgtac aaagcggtgc cgaagtgaaa     1680

aaaccgggcg caagcgtcaa ggtttcatgc aaggcgagtg gatacacctt taccaactat     1740

tacatgtact gggtgcggca ggcacccggg cagggactgg aatggatcgg tggtattaac     1800

ccaagtaatg gtggtacaaa tttcaacgaa aagtttaaga acaaagcgac gatgacagta     1860

gacaaatcta caagtaccgc atacatggag ctgagctcac tgagatctga ggacaccgca     1920

gtctattact gcacacggcg agattacaat tacgatggag ggttcgacta ctggggccaa     1980

gggactttgg tgactgtatc ctccggcggc ggagggtcag gtggaggagg aagcggtgga     2040

ggaggtagtg acatcgtcct tacgcaaagc ccggcgaccc tcagtttgag ccctggggaa     2100

agagcaacgc tgtcttgtag agcatccaaa tcagtctcaa cttctggttt taattacatg     2160

cactggtatc aacagaagcc aggacaagca cctagattgc tgatctttct ggcgtcaaat     2220

ctggcctctg gcgttccagc ccggtttagc ggttctggaa gcggaacgga ctttaccctt     2280

accatatcat cactcgaacc agaggacttt gcggtatatt actgccaaca tggacgggag     2340

ctgcccttga cgtttggtca aggaacgaag ttggagatat aa                        2382


<210>  34
<211>  793
<212>  PRT
<213>  Artificial

<220>
<223>  A02P03

<400>  34

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Arg 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Leu Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Lys Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Thr Ala 
                165                 170                 175     


Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln 
        195                 200                 205             


Phe Leu Val Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Tyr 
            260                 265                 270         


Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys 
            340                 345                 350         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        355                 360                 365             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    370                 375                 380                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
385                 390                 395                 400 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                405                 410                 415     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            420                 425                 430         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        435                 440                 445             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    450                 455                 460                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
465                 470                 475                 480 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                485                 490                 495     


Ala Leu Pro Pro Arg Val Asp Arg Ala Lys Arg Gly Ser Gly Glu Gly 
            500                 505                 510         


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
        515                 520                 525             


Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
    530                 535                 540                 


Val Thr Asn Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
545                 550                 555                 560 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
                565                 570                 575     


Phe Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly 
            580                 585                 590         


Leu Glu Trp Ile Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe 
        595                 600                 605             


Asn Glu Lys Phe Lys Asn Lys Ala Thr Met Thr Val Asp Lys Ser Thr 
    610                 615                 620                 


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
625                 630                 635                 640 


Val Tyr Tyr Cys Thr Arg Arg Asp Tyr Asn Tyr Asp Gly Gly Phe Asp 
                645                 650                 655     


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
        675                 680                 685             


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
    690                 695                 700                 


Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Phe Asn Tyr Met 
705                 710                 715                 720 


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Phe 
                725                 730                 735     


Leu Ala Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
            740                 745                 750         


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
        755                 760                 765             


Asp Phe Ala Val Tyr Tyr Cys Gln His Gly Arg Glu Leu Pro Leu Thr 
    770                 775                 780                 


Phe Gly Gln Gly Thr Lys Leu Glu Ile 
785                 790             


<210>  35
<211>  2367
<212>  DNA
<213>  Artificial

<220>
<223>  A02PL01

<400>  35
atgctgctgc tggtcacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctcagg tgcagctgaa agagtctggc cctggactgg tggccccaag ccagtctctg      120

agcatcacct gtaccgtgtc cggcttcagc ctgacaagct atggcgtgtc ctgggtccga      180

cagcctccta gaaaaggcct ggaatggctg ggcgtgatct gggaggatgg cagcaccaat      240

taccacagcg ccctgatcag cagactgtcc atcaacaagg acaacagcaa gagccaggtg      300

ttcctgaagc tgaacagcct gcagaccgac gacaccgcca cctactattg tgccaagcct      360

cactacggca gcagctacgt gggcgctatg gaatattggg gccagggcac aagcgtgacc      420

gtgtctagcg aaaagggaag aagtggcggc ggaggatctg gcggaggtgg aagcggaggc      480

ggtggatctg atatccagat gacacagagc cccgccagcc tgactgcttc tgtgggagag      540

acagtgacca tcacatgccg ggccagcgag aacatctact cctacgtggc ctggtatcag      600

caaaagcagg gcaagagccc tcagttcctg gtgtacaacg ccaagtctct ggccgagggc      660

gtgccaagca gattttctgg ctctggcagc ggcacccagt tctccctgaa gatcaattcc      720

ctgcagccag aggacttcgg caactactac tgccagcacc actatgtgtc tccctggacc      780

tttggcggag gcaccaagct ggaaatcaaa cggtacgtaa cgacgacacc agcaccccgc      840

cctcccacac cagcgcctac gatcgccagc caaccattgt cactgcggcc tgaggcttgc      900

agaccagctg ccggtggagc cgtccacaca cgcggacttg actttgcttg cgacatctac      960

atctgggctc ctctcgcagg cacctgcggt gtactgcttc tctcactggt cattacactc     1020

tattgccgat ttagtgtggt caaacgaggc cgaaaaaaac tcctttatat cttcaaacag     1080

cctttcatga gacctgtgca aacaacccag gaagaagacg gttgctcttg ccgctttccc     1140

gaagaagaag aaggaggttg cgaactgaga gttaaattct ctaggtctgc cgacgcccct     1200

gcctaccagc agggccagaa ccagctgtat aacgaactga acctcggacg acgagaagaa     1260

tatgatgtac tcgataaaag acgcggaagg gaccccgaaa tgggcgggaa gccccggagg     1320

aagaacccac aggagggtct gtataatgaa ctccagaaag acaaaatggc cgaagcatat     1380

tcagaaattg gcatgaaagg ggaacgaagg cggggtaaag ggcacgatgg cctttatcag     1440

ggacttagca cagccacaaa agacacttat gacgctctgc acatgcaagc cctcccccca     1500

cgggtcgaca gagccaagcg gggctctggc gagggcagag gctctctgct gacctgcgga     1560

gatgtggaag aaaatcccgg ccctatgtac agaatgcagc tgttgtcttg tattgccctt     1620

tctctcgccc tcgtaacaaa ttcagatatc cagatgacac aatctccgag ctccttgtcc     1680

gcatcagtgg gggatagagt taccataact tgccgcgcgt ctcaggatgt ctccactgct     1740

gtcgcgtggt atcagcagaa gccgggaaag gccccgaagt tgctcattta ctccgctagt     1800

tttttgtatt ccggcgttcc cagtcggttt tctgggtcag gcagcggtac cgactttaca     1860

cttacgatta gttctctgca gcctgaggat ttcgccacct attattgtca gcagtatttg     1920

taccaccctg caactttcgg ccagggaaca aaggtggaaa taaagggcgg tggtggaagt     1980

ggaggagggg gatccggagg cgggggttct gaagtccaat tggttgagtc cggcggaggc     2040

cttgtccaac cagggggatc acttcggctg tcatgcgcgg ccagtggttt cacgtttagt     2100

gacagctgga ttcattgggt aagacaggcg cccgggaaag gtctcgagtg ggtagcttgg     2160

atttctcctt acggaggttc tacctattat gcggattctg ttaaaggtcg attcacgatc     2220

tctgcagata ctagcaagaa tacggcgtat cttcaaatga atagccttcg ggctgaggac     2280

accgcggtgt actactgtgc ccgaagacat tggccgggcg gattcgatta ttggggtcag     2340

ggcactcttg tgacggtcag ctcataa                                         2367


<210>  36
<211>  788
<212>  PRT
<213>  Artificial

<220>
<223>  A02PL01

<400>  36

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Arg 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Leu Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Lys Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Thr Ala 
                165                 170                 175     


Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln 
        195                 200                 205             


Phe Leu Val Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Tyr 
            260                 265                 270         


Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg Lys 
            340                 345                 350         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        355                 360                 365             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    370                 375                 380                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
385                 390                 395                 400 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                405                 410                 415     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            420                 425                 430         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        435                 440                 445             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    450                 455                 460                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
465                 470                 475                 480 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                485                 490                 495     


Ala Leu Pro Pro Arg Val Asp Arg Ala Lys Arg Gly Ser Gly Glu Gly 
            500                 505                 510         


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
        515                 520                 525             


Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
    530                 535                 540                 


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
545                 550                 555                 560 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
                565                 570                 575     


Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            580                 585                 590         


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
        595                 600                 605             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    610                 615                 620                 


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu 
625                 630                 635                 640 


Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
            660                 665                 670         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        675                 680                 685             


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile 
    690                 695                 700                 


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp 
705                 710                 715                 720 


Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                725                 730                 735     


Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
            740                 745                 750         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        755                 760                 765             


Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    770                 775                 780                 


Thr Val Ser Ser 
785             


<210>  37
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Linker peptide

<400>  37

Glu Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  38
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  38

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  39
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  39

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  40
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  40

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  41
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  T2A

<400>  41

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  42
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  43
<211>  245
<212>  PRT
<213>  Artificial

<220>
<223>  Anti-PD-1 scFv

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Met Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Asp Tyr Asn Tyr Asp Gly Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Lys Ser Val Ser Thr Ser Gly Phe Asn Tyr Met His Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Phe Leu Ala Ser Asn 
            180                 185                 190         


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gln His Gly Arg Glu Leu Pro Leu Thr Phe Gly Gln Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile 
                245 


<210>  44
<211>  240
<212>  PRT
<213>  Artificial

<220>
<223>  Anti-PD-L1 scFv

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro Tyr 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp Pro 
    210                 215                 220                 


Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 240 


<210>  45
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  45

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  46
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  46

Ile Trp Glu Asp Gly Ser Thr 
1               5           


<210>  47
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  47

Ala Lys Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr 
1               5                   10                  15  


<210>  48
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  48

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  49
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  49

Asn Ala Lys 
1           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  50

Gln His His Tyr Val Ser Pro Trp Thr 
1               5                   


<210>  51
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  51

Gly Phe Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  52
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  52

Ile Trp Glu Asp Gly Ser Thr 
1               5           


<210>  53
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  53

Ala Arg Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr 
1               5                   10                  15  


<210>  54
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  54

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  55
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  55

Asn Ala Lys 
1           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  56

Gln His His Tyr Val Ser Pro Trp Thr 
1               5                   


<210>  57
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  57

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  58
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  58

Ile Trp Glu Asp Gly Ser Thr 
1               5           


<210>  59
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  59

Ala Arg Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr 
1               5                   10                  15  


<210>  60
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  60

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  61
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  61

Asn Ala Lys 
1           


<210>  62
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  62

Gln His His Tyr Val Ser Pro Trp Thr 
1               5                   


<210>  63
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  63

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  64
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  64

Ile Trp Glu Asp Gly Ser Thr 
1               5           


<210>  65
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  65

Ala Arg Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr 
1               5                   10                  15  


<210>  66
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  66

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  67
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  67

Asn Ala Lys 
1           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  68

Gln His His Tyr Val Ser Pro Trp Thr 
1               5                   


<210>  69
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  69

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  70
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  70

Ile Trp Glu Asp Gly Ser Thr 
1               5           


<210>  71
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  71

Ala Lys Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr 
1               5                   10                  15  


<210>  72
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  72

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  73
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  73

Asn Ala Lys 
1           


<210>  74
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  74

Gln His His Tyr Val Ser Pro Trp Thr 
1               5                   


<210>  75
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  75

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  76
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  76

Ile Trp Glu Asp Gly Ser Thr 
1               5           


<210>  77
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  77

Ala Lys Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr 
1               5                   10                  15  


<210>  78
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  78

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  79
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  79

Asn Ala Lys 
1           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  80

Gln His His Tyr Val Ser Pro Trp Thr 
1               5                   


<210>  81
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  81

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  82
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  82

Ile Trp Glu Asp Gly Ser Thr 
1               5           


<210>  83
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  83

Ala Arg Pro His Tyr Gly Ser Ser Tyr Val Gly Ala Met Glu Tyr 
1               5                   10                  15  


<210>  84
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  84

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  85
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  85

Asn Ala Lys 
1           


<210>  86
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR sequence

<400>  86

Gln His His Tyr Val Ser Pro Trp Thr 
1               5                   


<210>  87
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker peptide

<400>  87

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  88
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Linker peptide

<400>  88

Gly Gly Gly Gly Ser 
1               5   


<210>  89
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  89

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  90
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  CD28 and 4-1BB intracellular signaling domain

<400>  90

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg 
        35                  40                  45              


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    50                  55                  60                  


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
65                  70                  75                  80  


Glu Glu Glu Gly Gly Cys Glu Leu 
                85              


<210>  91
<211>  542
<212>  PRT
<213>  Artificial

<220>
<223>  A02 third generation CAR

<400>  91

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Arg 
    50                  55                  60                  


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser 
                85                  90                  95      


Lys Ser Gln Val Phe Leu Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Lys Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Thr Ala 
                165                 170                 175     


Ser Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln 
        195                 200                 205             


Phe Leu Val Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Tyr 
            260                 265                 270         


Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    370                 375                 380                 


Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
385                 390                 395                 400 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                405                 410                 415     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            420                 425                 430         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        435                 440                 445             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    450                 455                 460                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
465                 470                 475                 480 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                485                 490                 495     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            500                 505                 510         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        515                 520                 525             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540         


<210>  92
<211>  542
<212>  PRT
<213>  Artificial

<220>
<223>  A03 third generation CAR

<400>  92

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Arg Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Thr Phe Thr Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Arg Gly Leu Glu Trp Ile Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Val Thr Met Leu Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Ser Leu Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Tyr 
            260                 265                 270         


Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    370                 375                 380                 


Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
385                 390                 395                 400 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                405                 410                 415     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            420                 425                 430         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        435                 440                 445             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    450                 455                 460                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
465                 470                 475                 480 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                485                 490                 495     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            500                 505                 510         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        515                 520                 525             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540         


<210>  93
<211>  541
<212>  PRT
<213>  Artificial

<220>
<223>  A06 third generation CAR

<400>  93

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Ala Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Ser Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Glu Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Ala Leu Ile Ser Arg Val Ser Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Asp Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Pro His Tyr Gly Ser Ser Tyr Val Gly 
        115                 120                 125             


Ala Met Glu Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Lys Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
                165                 170                 175     


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile 
            180                 185                 190         


Tyr Ser Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Asn Ala Lys Ser Leu Ala Glu Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Asn Tyr Tyr Cys Gln His His Tyr Val 
                245                 250                 255     


Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Tyr Val 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
            340                 345                 350         


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
        355                 360                 365             


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe 
    370                 375                 380                 


Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
385                 390                 395                 400 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                405                 410                 415     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            420                 425                 430         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        435                 440                 445             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    450                 455                 460                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
465                 470                 475                 480 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                485                 490                 495     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            500                 505                 510         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        515                 520                 525             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540     


