                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE

<130>  20378-202583

<150>  62/868,407
<151>  2019-06-28

<150>  63/019,970
<151>  2020-05-04

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
gatcgatatc ttctctggag agctcacagc                                        30


<210>  2
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
gcaggcatcg taaaagggca gcacgtcgag                                        30


<210>  3
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
gtgctgccct tttacgatgc ctgccccaag                                        30


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
gatcgctagc aagtaggcca gcaag                                             25


<210>  5
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
tgctgccctt tacagagctc gacctctgtt ac                                     32


<210>  6
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6
cgagctctgt aaagggcagc acgtcgag                                          28


<210>  7
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
tctgtgagac actggacact gaagctggac g                                      31


<210>  8
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8
tcagtgtcca gtgtctcaca agaagtctcc cg                                     32


<210>  9
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
gctggacact gtggccgcac gctcctttc                                         29


<210>  10
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
gtgcggccac agtgtccagc tcgcagtc                                          28


<210>  11
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
acgctgtgag caggccaagt cacacttttg tg                                     32


<210>  12
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
acttggcctg ctcacagcgt ggaccatc                                          28


<210>  13
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
aggctgccag ctcacaatgg cccatcccta c                                      31


<210>  14
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
ccattgtgag ctggcagcct gccatagtg                                         29


<210>  15
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
ctgtcgactc actgtgacca acccctgtg                                         29


<210>  16
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
tggtcacagt gagtcgacag tctttgccac c                                      31


<210>  17
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
tggctgtact gatgcctgcc tcctgaacc                                         29


<210>  18
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
ggcaggcatc agtacagcca ggctccacat tc                                     32


<210>  19
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
aggctgtgtg tattttggtc agcactgtga gcac                                   34


<210>  20
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20
gctgaccaaa atacacacag cctgggccat ag                                     32


<210>  21
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21
tgtgagtggc aagacgaatg gccagtgcc                                         29


<210>  22
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22
ccattcgtct tgccactcac agtcacaag                                         29


<210>  23
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23
caactgcaac ccccacagcg ggcagtg                                           27


<210>  24
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24
ctgtgggggt tgcagttggg gtcaaagc                                          28


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25
gcatcgtaga gtgggaggca tgagtcactg                                        30


<210>  26
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26
atgccaccca ctctacgatg cctgccccaa g                                      31


<210>  27
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  27

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  28
<211>  3014
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Pro Pro Pro Pro Pro Val Leu Pro Val Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ala Ala Ala Leu Pro Ala Met Gly Leu Arg Ala Ala Ala Trp Glu 
            20                  25                  30          


Pro Arg Val Pro Gly Gly Thr Arg Ala Phe Ala Leu Arg Pro Gly Cys 
        35                  40                  45              


Thr Tyr Ala Val Gly Ala Ala Cys Thr Pro Arg Ala Pro Arg Glu Leu 
    50                  55                  60                  


Leu Asp Val Gly Arg Asp Gly Arg Leu Ala Gly Arg Arg Arg Val Ser 
65                  70                  75                  80  


Gly Ala Gly Arg Pro Leu Pro Leu Gln Val Arg Leu Val Ala Arg Ser 
                85                  90                  95      


Ala Pro Thr Ala Leu Ser Arg Arg Leu Arg Ala Arg Thr His Leu Pro 
            100                 105                 110         


Gly Cys Gly Ala Arg Ala Arg Leu Cys Gly Thr Gly Ala Arg Leu Cys 
        115                 120                 125             


Gly Ala Leu Cys Phe Pro Val Pro Gly Gly Cys Ala Ala Ala Gln His 
    130                 135                 140                 


Ser Ala Leu Ala Ala Pro Thr Thr Leu Pro Ala Cys Arg Cys Pro Pro 
145                 150                 155                 160 


Arg Pro Arg Pro Arg Cys Pro Gly Arg Pro Ile Cys Leu Pro Pro Gly 
                165                 170                 175     


Gly Ser Val Arg Leu Arg Leu Leu Cys Ala Leu Arg Arg Ala Ala Gly 
            180                 185                 190         


Ala Val Arg Val Gly Leu Ala Leu Glu Ala Ala Thr Ala Gly Thr Pro 
        195                 200                 205             


Ser Ala Ser Pro Ser Pro Ser Pro Pro Leu Pro Pro Asn Leu Pro Glu 
    210                 215                 220                 


Ala Arg Ala Gly Pro Ala Arg Arg Ala Arg Arg Gly Thr Ser Gly Arg 
225                 230                 235                 240 


Gly Ser Leu Lys Phe Pro Met Pro Asn Tyr Gln Val Ala Leu Phe Glu 
                245                 250                 255     


Asn Glu Pro Ala Gly Thr Leu Ile Leu Gln Leu His Ala His Tyr Thr 
            260                 265                 270         


Ile Glu Gly Glu Glu Glu Arg Val Ser Tyr Tyr Met Glu Gly Leu Phe 
        275                 280                 285             


Asp Glu Arg Ser Arg Gly Tyr Phe Arg Ile Asp Ser Ala Thr Gly Ala 
    290                 295                 300                 


Val Ser Thr Asp Ser Val Leu Asp Arg Glu Thr Lys Glu Thr His Val 
305                 310                 315                 320 


Leu Arg Val Lys Ala Val Asp Tyr Ser Thr Pro Pro Arg Ser Ala Thr 
                325                 330                 335     


Thr Tyr Ile Thr Val Leu Val Lys Asp Thr Asn Asp His Ser Pro Val 
            340                 345                 350         


Phe Glu Gln Ser Glu Tyr Arg Glu Arg Val Arg Glu Asn Leu Glu Val 
        355                 360                 365             


Gly Tyr Glu Val Leu Thr Ile Arg Ala Ser Asp Arg Asp Ser Pro Ile 
    370                 375                 380                 


Asn Ala Asn Leu Arg Tyr Arg Val Leu Gly Gly Ala Trp Asp Val Phe 
385                 390                 395                 400 


Gln Leu Asn Glu Ser Ser Gly Val Val Ser Thr Arg Ala Val Leu Asp 
                405                 410                 415     


Arg Glu Glu Ala Ala Glu Tyr Gln Leu Leu Val Glu Ala Asn Asp Gln 
            420                 425                 430         


Gly Arg Asn Pro Gly Pro Leu Ser Ala Thr Ala Thr Val Tyr Ile Glu 
        435                 440                 445             


Val Glu Asp Glu Asn Asp Asn Tyr Pro Gln Phe Ser Glu Gln Asn Tyr 
    450                 455                 460                 


Val Val Gln Val Pro Glu Asp Val Gly Leu Asn Thr Ala Val Leu Arg 
465                 470                 475                 480 


Val Gln Ala Thr Asp Arg Asp Gln Gly Gln Asn Ala Ala Ile His Tyr 
                485                 490                 495     


Ser Ile Leu Ser Gly Asn Val Ala Gly Gln Phe Tyr Leu His Ser Leu 
            500                 505                 510         


Ser Gly Ile Leu Asp Val Ile Asn Pro Leu Asp Phe Glu Asp Val Gln 
        515                 520                 525             


Lys Tyr Ser Leu Ser Ile Lys Ala Gln Asp Gly Gly Arg Pro Pro Leu 
    530                 535                 540                 


Ile Asn Ser Ser Gly Val Val Ser Val Gln Val Leu Asp Val Asn Asp 
545                 550                 555                 560 


Asn Glu Pro Ile Phe Val Ser Ser Pro Phe Gln Ala Thr Val Leu Glu 
                565                 570                 575     


Asn Val Pro Leu Gly Tyr Pro Val Val His Ile Gln Ala Val Asp Ala 
            580                 585                 590         


Asp Ser Gly Glu Asn Ala Arg Leu His Tyr Arg Leu Val Asp Thr Ala 
        595                 600                 605             


Ser Thr Phe Leu Gly Gly Gly Ser Ala Gly Pro Lys Asn Pro Ala Pro 
    610                 615                 620                 


Thr Pro Asp Phe Pro Phe Gln Ile His Asn Ser Ser Gly Trp Ile Thr 
625                 630                 635                 640 


Val Cys Ala Glu Leu Asp Arg Glu Glu Val Glu His Tyr Ser Phe Gly 
                645                 650                 655     


Val Glu Ala Val Asp His Gly Ser Pro Pro Met Ser Ser Ser Thr Ser 
            660                 665                 670         


Val Ser Ile Thr Val Leu Asp Val Asn Asp Asn Asp Pro Val Phe Thr 
        675                 680                 685             


Gln Pro Thr Tyr Glu Leu Arg Leu Asn Glu Asp Ala Ala Val Gly Ser 
    690                 695                 700                 


Ser Val Leu Thr Leu Gln Ala Arg Asp Arg Asp Ala Asn Ser Val Ile 
705                 710                 715                 720 


Thr Tyr Gln Leu Thr Gly Gly Asn Thr Arg Asn Arg Phe Ala Leu Ser 
                725                 730                 735     


Ser Gln Arg Gly Gly Gly Leu Ile Thr Leu Ala Leu Pro Leu Asp Tyr 
            740                 745                 750         


Lys Gln Glu Gln Gln Tyr Val Leu Ala Val Thr Ala Ser Asp Gly Thr 
        755                 760                 765             


Arg Ser His Thr Ala His Val Leu Ile Asn Val Thr Asp Ala Asn Thr 
    770                 775                 780                 


His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Ser Val Ser Glu 
785                 790                 795                 800 


Asp Arg Pro Val Gly Thr Ser Ile Ala Thr Leu Ser Ala Asn Asp Glu 
                805                 810                 815     


Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Val Ile Gln Asp Pro Val 
            820                 825                 830         


Pro Gln Phe Arg Ile Asp Pro Asp Ser Gly Thr Met Tyr Thr Met Met 
        835                 840                 845             


Glu Leu Asp Tyr Glu Asn Gln Val Ala Tyr Thr Leu Thr Ile Met Ala 
    850                 855                 860                 


Gln Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Thr Leu Glu Ile 
865                 870                 875                 880 


Leu Ile Leu Asp Ala Asn Asp Asn Ala Pro Gln Phe Leu Trp Asp Phe 
                885                 890                 895     


Tyr Gln Gly Ser Ile Phe Glu Asp Ala Pro Pro Ser Thr Ser Ile Leu 
            900                 905                 910         


Gln Val Ser Ala Thr Asp Arg Asp Ser Gly Pro Asn Gly Arg Leu Leu 
        915                 920                 925             


Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe Tyr Ile Glu 
    930                 935                 940                 


Pro Thr Ser Gly Val Ile Arg Thr Gln Arg Arg Leu Asp Arg Glu Asn 
945                 950                 955                 960 


Val Ala Val Tyr Asn Leu Trp Ala Leu Ala Val Asp Arg Gly Ser Pro 
                965                 970                 975     


Thr Pro Leu Ser Ala Ser Val Glu Ile Gln Val Thr Ile Leu Asp Ile 
            980                 985                 990         


Asn Asp Asn Ala Pro Met Phe Glu  Lys Asp Glu Leu Glu  Leu Phe Val 
        995                 1000                 1005             


Glu Glu  Asn Asn Pro Val Gly  Ser Val Val Ala Lys  Ile Arg Ala 
    1010                 1015                 1020             


Asn Asp  Pro Asp Glu Gly Pro  Asn Ala Gln Ile Met  Tyr Gln Ile 
    1025                 1030                 1035             


Val Glu  Gly Asp Met Arg His  Phe Phe Gln Leu Asp  Leu Leu Asn 
    1040                 1045                 1050             


Gly Asp  Leu Arg Ala Met Val  Glu Leu Asp Phe Glu  Val Arg Arg 
    1055                 1060                 1065             


Glu Tyr  Val Leu Val Val Gln  Ala Thr Ser Ala Pro  Leu Val Ser 
    1070                 1075                 1080             


Arg Ala  Thr Val His Ile Leu  Leu Val Asp Gln Asn  Asp Asn Pro 
    1085                 1090                 1095             


Pro Val  Leu Pro Asp Phe Gln  Ile Leu Phe Asn Asn  Tyr Val Thr 
    1100                 1105                 1110             


Asn Lys  Ser Asn Ser Phe Pro  Thr Gly Val Ile Gly  Cys Ile Pro 
    1115                 1120                 1125             


Ala His  Asp Pro Asp Val Ser  Asp Ser Leu Asn Tyr  Thr Phe Val 
    1130                 1135                 1140             


Gln Gly  Asn Glu Leu Arg Leu  Leu Leu Leu Asp Pro  Ala Thr Gly 
    1145                 1150                 1155             


Glu Leu  Gln Leu Ser Arg Asp  Leu Asp Asn Asn Arg  Pro Leu Glu 
    1160                 1165                 1170             


Ala Leu  Met Glu Val Ser Val  Ser Asp Gly Ile His  Ser Val Thr 
    1175                 1180                 1185             


Ala Phe  Cys Thr Leu Arg Val  Thr Ile Ile Thr Asp  Asp Met Leu 
    1190                 1195                 1200             


Thr Asn  Ser Ile Thr Val Arg  Leu Glu Asn Met Ser  Gln Glu Lys 
    1205                 1210                 1215             


Phe Leu  Ser Pro Leu Leu Ala  Leu Phe Val Glu Gly  Val Ala Ala 
    1220                 1225                 1230             


Val Leu  Ser Thr Thr Lys Asp  Asp Val Phe Val Phe  Asn Val Gln 
    1235                 1240                 1245             


Asn Asp  Thr Asp Val Ser Ser  Asn Ile Leu Asn Val  Thr Phe Ser 
    1250                 1255                 1260             


Ala Leu  Leu Pro Gly Gly Val  Arg Gly Gln Phe Phe  Pro Ser Glu 
    1265                 1270                 1275             


Asp Leu  Gln Glu Gln Ile Tyr  Leu Asn Arg Thr Leu  Leu Thr Thr 
    1280                 1285                 1290             


Ile Ser  Thr Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1295                 1300                 1305             


Arg Glu  Pro Cys Glu Asn Tyr  Met Lys Cys Val Ser  Val Leu Arg 
    1310                 1315                 1320             


Phe Asp  Ser Ser Ala Pro Phe  Leu Ser Ser Thr Thr  Val Leu Phe 
    1325                 1330                 1335             


Arg Pro  Ile His Pro Ile Asn  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1340                 1345                 1350             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Ile Asp  Leu Cys Tyr 
    1355                 1360                 1365             


Ser Asp  Pro Cys Gly Ala Asn  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1370                 1375                 1380             


Gly Tyr  Thr Cys Glu Cys Phe  Glu Asp Phe Thr Gly  Glu His Cys 
    1385                 1390                 1395             


Glu Val  Asp Ala Arg Ser Gly  Arg Cys Ala Asn Gly  Val Cys Lys 
    1400                 1405                 1410             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Ile Gly Gly  Phe His Cys 
    1415                 1420                 1425             


Val Cys  Pro Pro Gly Glu Tyr  Glu Arg Pro Tyr Cys  Glu Val Thr 
    1430                 1435                 1440             


Thr Arg  Ser Phe Pro Pro Gln  Ser Phe Val Thr Phe  Arg Gly Leu 
    1445                 1450                 1455             


Arg Gln  Arg Phe His Phe Thr  Ile Ser Leu Thr Phe  Ala Thr Gln 
    1460                 1465                 1470             


Glu Arg  Asn Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1475                 1480                 1485             


His Asp  Phe Ile Ala Leu Glu  Ile Val Asp Glu Gln  Val Gln Leu 
    1490                 1495                 1500             


Thr Phe  Ser Ala Gly Glu Thr  Thr Thr Thr Val Ala  Pro Lys Val 
    1505                 1510                 1515             


Pro Ser  Gly Val Ser Asp Gly  Arg Trp His Ser Val  Gln Val Gln 
    1520                 1525                 1530             


Tyr Tyr  Asn Lys Pro Asn Ile  Gly His Leu Gly Leu  Pro His Gly 
    1535                 1540                 1545             


Pro Ser  Gly Glu Lys Met Ala  Val Val Thr Val Asp  Asp Cys Asp 
    1550                 1555                 1560             


Thr Thr  Met Ala Val Arg Phe  Gly Lys Asp Ile Gly  Asn Tyr Ser 
    1565                 1570                 1575             


Cys Ala  Ala Gln Gly Thr Gln  Thr Gly Ser Lys Lys  Ser Leu Asp 
    1580                 1585                 1590             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asn  Leu Pro Glu 
    1595                 1600                 1605             


Asp Phe  Pro Val His Asn Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1610                 1615                 1620             


Leu Ser  Val Asp Gly Lys Asn  Val Asp Met Ala Gly  Phe Ile Ala 
    1625                 1630                 1635             


Asn Asn  Gly Thr Arg Glu Gly  Cys Ala Ala Arg Arg  Asn Phe Cys 
    1640                 1645                 1650             


Asp Gly  Arg Arg Cys Gln Asn  Gly Gly Thr Cys Val  Asn Arg Trp 
    1655                 1660                 1665             


Asn Met  Tyr Leu Cys Glu Cys  Pro Leu Arg Phe Gly  Gly Lys Asn 
    1670                 1675                 1680             


Cys Glu  Gln Ala Met Pro His  Pro Gln Leu Phe Ser  Gly Glu Ser 
    1685                 1690                 1695             


Val Val  Ser Trp Ser Asp Leu  Asn Ile Ile Ile Ser  Val Pro Trp 
    1700                 1705                 1710             


Tyr Leu  Gly Leu Met Phe Arg  Thr Arg Lys Glu Asp  Ser Val Leu 
    1715                 1720                 1725             


Met Glu  Ala Thr Ser Gly Gly  Pro Thr Ser Phe Arg  Leu Gln Ile 
    1730                 1735                 1740             


Leu Asn  Asn Tyr Leu Gln Phe  Glu Val Ser His Gly  Pro Ser Asp 
    1745                 1750                 1755             


Val Glu  Ser Val Met Leu Ser  Gly Leu Arg Val Thr  Asp Gly Glu 
    1760                 1765                 1770             


Trp His  His Leu Leu Ile Glu  Leu Lys Asn Val Lys  Glu Asp Ser 
    1775                 1780                 1785             


Glu Met  Lys His Leu Val Thr  Met Thr Leu Asp Tyr  Gly Met Asp 
    1790                 1795                 1800             


Gln Asn  Lys Ala Asp Ile Gly  Gly Met Leu Pro Gly  Leu Thr Val 
    1805                 1810                 1815             


Arg Ser  Val Val Val Gly Gly  Ala Ser Glu Asp Lys  Val Ser Val 
    1820                 1825                 1830             


Arg Arg  Gly Phe Arg Gly Cys  Met Gln Gly Val Arg  Met Gly Gly 
    1835                 1840                 1845             


Thr Pro  Thr Asn Val Ala Thr  Leu Asn Met Asn Asn  Ala Leu Lys 
    1850                 1855                 1860             


Val Arg  Val Lys Asp Gly Cys  Asp Val Asp Asp Pro  Cys Thr Ser 
    1865                 1870                 1875             


Ser Pro  Cys Pro Pro Asn Ser  Arg Cys His Asp Ala  Trp Glu Asp 
    1880                 1885                 1890             


Tyr Ser  Cys Val Cys Asp Lys  Gly Tyr Leu Gly Ile  Asn Cys Val 
    1895                 1900                 1905             


Asp Ala  Cys His Leu Asn Pro  Cys Glu Asn Met Gly  Ala Cys Val 
    1910                 1915                 1920             


Arg Ser  Pro Gly Ser Pro Gln  Gly Tyr Val Cys Glu  Cys Gly Pro 
    1925                 1930                 1935             


Ser His  Tyr Gly Pro Tyr Cys  Glu Asn Lys Leu Asp  Leu Pro Cys 
    1940                 1945                 1950             


Pro Arg  Gly Trp Trp Gly Asn  Pro Val Cys Gly Pro  Cys His Cys 
    1955                 1960                 1965             


Ala Val  Ser Lys Gly Phe Asp  Pro Asp Cys Asn Lys  Thr Asn Gly 
    1970                 1975                 1980             


Gln Cys  Gln Cys Lys Glu Asn  Tyr Tyr Lys Leu Leu  Ala Gln Asp 
    1985                 1990                 1995             


Thr Cys  Leu Pro Cys Asp Cys  Phe Pro His Gly Ser  His Ser Arg 
    2000                 2005                 2010             


Thr Cys  Asp Met Ala Thr Gly  Gln Cys Ala Cys Lys  Pro Gly Val 
    2015                 2020                 2025             


Ile Gly  Arg Gln Cys Asn Arg  Cys Asp Asn Pro Phe  Ala Glu Val 
    2030                 2035                 2040             


Thr Thr  Leu Gly Cys Glu Val  Ile Tyr Asn Gly Cys  Pro Lys Ala 
    2045                 2050                 2055             


Phe Glu  Ala Gly Ile Trp Trp  Pro Gln Thr Lys Phe  Gly Gln Pro 
    2060                 2065                 2070             


Ala Ala  Val Pro Cys Pro Lys  Gly Ser Val Gly Asn  Ala Val Arg 
    2075                 2080                 2085             


His Cys  Ser Gly Glu Lys Gly  Trp Leu Pro Pro Glu  Leu Phe Asn 
    2090                 2095                 2100             


Cys Thr  Thr Ile Ser Phe Val  Asp Leu Arg Ala Met  Asn Glu Lys 
    2105                 2110                 2115             


Leu Ser  Arg Asn Glu Thr Gln  Val Asp Gly Ala Arg  Ala Leu Gln 
    2120                 2125                 2130             


Leu Val  Arg Ala Leu Arg Ser  Ala Thr Gln His Thr  Gly Thr Leu 
    2135                 2140                 2145             


Phe Gly  Asn Asp Val Arg Thr  Ala Tyr Gln Leu Leu  Gly His Val 
    2150                 2155                 2160             


Leu Gln  His Glu Ser Trp Gln  Gln Gly Phe Asp Leu  Ala Ala Thr 
    2165                 2170                 2175             


Gln Asp  Ala Asp Phe His Glu  Asp Val Ile His Ser  Gly Ser Ala 
    2180                 2185                 2190             


Leu Leu  Ala Pro Ala Thr Arg  Ala Ala Trp Glu Gln  Ile Gln Arg 
    2195                 2200                 2205             


Ser Glu  Gly Gly Thr Ala Gln  Leu Leu Arg Arg Leu  Glu Gly Tyr 
    2210                 2215                 2220             


Phe Ser  Asn Val Ala Arg Asn  Val Arg Arg Thr Tyr  Leu Arg Pro 
    2225                 2230                 2235             


Phe Val  Ile Val Thr Ala Asn  Met Ile Leu Ala Val  Asp Ile Phe 
    2240                 2245                 2250             


Asp Lys  Phe Asn Phe Thr Gly  Ala Arg Val Pro Arg  Phe Asp Thr 
    2255                 2260                 2265             


Ile His  Glu Glu Phe Pro Arg  Glu Leu Glu Ser Ser  Val Ser Phe 
    2270                 2275                 2280             


Pro Ala  Asp Phe Phe Arg Pro  Pro Glu Glu Lys Glu  Gly Pro Leu 
    2285                 2290                 2295             


Leu Arg  Pro Ala Gly Arg Arg  Thr Thr Pro Gln Thr  Thr Arg Pro 
    2300                 2305                 2310             


Gly Pro  Gly Thr Glu Arg Glu  Ala Pro Ile Ser Arg  Arg Arg Arg 
    2315                 2320                 2325             


His Pro  Asp Asp Ala Gly Gln  Phe Ala Val Ala Leu  Val Ile Ile 
    2330                 2335                 2340             


Tyr Arg  Thr Leu Gly Gln Leu  Leu Pro Glu Arg Tyr  Asp Pro Asp 
    2345                 2350                 2355             


Arg Arg  Ser Leu Arg Leu Pro  His Arg Pro Ile Ile  Asn Thr Pro 
    2360                 2365                 2370             


Met Val  Ser Thr Leu Val Tyr  Ser Glu Gly Ala Pro  Leu Pro Arg 
    2375                 2380                 2385             


Pro Leu  Glu Arg Pro Val Leu  Val Glu Phe Ala Leu  Leu Glu Val 
    2390                 2395                 2400             


Glu Glu  Arg Thr Lys Pro Val  Cys Val Phe Trp Asn  His Ser Leu 
    2405                 2410                 2415             


Ala Val  Gly Gly Thr Gly Gly  Trp Ser Ala Arg Gly  Cys Glu Leu 
    2420                 2425                 2430             


Leu Ser  Arg Asn Arg Thr His  Val Ala Cys Gln Cys  Ser His Thr 
    2435                 2440                 2445             


Ala Ser  Phe Ala Val Leu Met  Asp Ile Ser Arg Arg  Glu Asn Gly 
    2450                 2455                 2460             


Glu Val  Leu Pro Leu Lys Ile  Val Thr Tyr Ala Ala  Val Ser Leu 
    2465                 2470                 2475             


Ser Leu  Ala Ala Leu Leu Val  Ala Phe Val Leu Leu  Ser Leu Val 
    2480                 2485                 2490             


Arg Met  Leu Arg Ser Asn Leu  His Ser Ile His Lys  His Leu Ala 
    2495                 2500                 2505             


Val Ala  Leu Phe Leu Ser Gln  Leu Val Phe Val Ile  Gly Ile Asn 
    2510                 2515                 2520             


Gln Thr  Glu Asn Pro Phe Leu  Cys Thr Val Val Ala  Ile Leu Leu 
    2525                 2530                 2535             


His Tyr  Ile Tyr Met Ser Thr  Phe Ala Trp Thr Leu  Val Glu Ser 
    2540                 2545                 2550             


Leu His  Val Tyr Arg Met Leu  Thr Glu Val Arg Asn  Ile Asp Thr 
    2555                 2560                 2565             


Gly Pro  Met Arg Phe Tyr Tyr  Val Val Gly Trp Gly  Ile Pro Ala 
    2570                 2575                 2580             


Ile Val  Thr Gly Leu Ala Val  Gly Leu Asp Pro Gln  Gly Tyr Gly 
    2585                 2590                 2595             


Asn Pro  Asp Phe Cys Trp Leu  Ser Leu Gln Asp Thr  Leu Ile Trp 
    2600                 2605                 2610             


Ser Phe  Ala Gly Pro Ile Gly  Ala Val Ile Ile Ile  Asn Thr Val 
    2615                 2620                 2625             


Thr Ser  Val Leu Ser Ala Lys  Val Ser Cys Gln Arg  Lys His His 
    2630                 2635                 2640             


Tyr Tyr  Gly Lys Lys Gly Ile  Val Ser Leu Leu Arg  Thr Ala Phe 
    2645                 2650                 2655             


Leu Leu  Leu Leu Leu Ile Ser  Ala Thr Trp Leu Leu  Gly Leu Leu 
    2660                 2665                 2670             


Ala Val  Asn Arg Asp Ala Leu  Ser Phe His Tyr Leu  Phe Ala Ile 
    2675                 2680                 2685             


Phe Ser  Gly Leu Gln Gly Pro  Phe Val Leu Leu Phe  His Cys Val 
    2690                 2695                 2700             


Leu Asn  Gln Glu Val Arg Lys  His Leu Lys Gly Val  Leu Gly Gly 
    2705                 2710                 2715             


Arg Lys  Leu His Leu Glu Asp  Ser Ala Thr Thr Arg  Ala Thr Leu 
    2720                 2725                 2730             


Leu Thr  Arg Ser Leu Asn Cys  Asn Thr Thr Phe Gly  Asp Gly Pro 
    2735                 2740                 2745             


Asp Met  Leu Arg Thr Asp Leu  Gly Glu Ser Thr Ala  Ser Leu Asp 
    2750                 2755                 2760             


Ser Ile  Val Arg Asp Glu Gly  Ile Gln Lys Leu Gly  Val Ser Ser 
    2765                 2770                 2775             


Gly Leu  Val Arg Gly Ser His  Gly Glu Pro Asp Ala  Ser Leu Met 
    2780                 2785                 2790             


Pro Arg  Ser Cys Lys Asp Pro  Pro Gly His Asp Ser  Asp Ser Asp 
    2795                 2800                 2805             


Ser Glu  Leu Ser Leu Asp Glu  Gln Ser Ser Ser Tyr  Ala Ser Ser 
    2810                 2815                 2820             


His Ser  Ser Asp Ser Glu Asp  Asp Gly Val Gly Ala  Glu Glu Lys 
    2825                 2830                 2835             


Trp Asp  Pro Ala Arg Gly Ala  Val His Ser Thr Pro  Lys Gly Asp 
    2840                 2845                 2850             


Ala Val  Ala Asn His Val Pro  Ala Gly Trp Pro Asp  Gln Ser Leu 
    2855                 2860                 2865             


Ala Glu  Ser Asp Ser Glu Asp  Pro Ser Gly Lys Pro  Arg Leu Lys 
    2870                 2875                 2880             


Val Glu  Thr Lys Val Ser Val  Glu Leu His Arg Glu  Glu Gln Gly 
    2885                 2890                 2895             


Ser His  Arg Gly Glu Tyr Pro  Pro Asp Gln Glu Ser  Gly Gly Ala 
    2900                 2905                 2910             


Ala Arg  Leu Ala Ser Ser Gln  Pro Pro Glu Gln Arg  Lys Gly Ile 
    2915                 2920                 2925             


Leu Lys  Asn Lys Val Thr Tyr  Pro Pro Pro Leu Thr  Leu Thr Glu 
    2930                 2935                 2940             


Gln Thr  Leu Lys Gly Arg Leu  Arg Glu Lys Leu Ala  Asp Cys Glu 
    2945                 2950                 2955             


Gln Ser  Pro Thr Ser Ser Arg  Thr Ser Ser Leu Gly  Ser Gly Gly 
    2960                 2965                 2970             


Pro Asp  Cys Ala Ile Thr Val  Lys Ser Pro Gly Arg  Glu Pro Gly 
    2975                 2980                 2985             


Arg Asp  His Leu Asn Gly Val  Ala Met Asn Val Arg  Thr Gly Ser 
    2990                 2995                 3000             


Ala Gln  Ala Asp Gly Ser Asp  Ser Glu Lys Pro 
    3005                 3010                 


<210>  29
<211>  2923
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Ser Pro Ala Thr Gly Val Pro Leu Pro Thr Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Leu Leu Gly Asp 
            20                  25                  30          


Gln Val Gly Pro Cys Arg Ser Leu Gly Ser Arg Gly Arg Gly Ser Ser 
        35                  40                  45              


Gly Ala Cys Ala Pro Met Gly Trp Leu Cys Pro Ser Ser Ala Ser Asn 
    50                  55                  60                  


Leu Trp Leu Tyr Thr Ser Arg Cys Arg Asp Ala Gly Thr Glu Leu Thr 
65                  70                  75                  80  


Gly His Leu Val Pro His His Asp Gly Leu Arg Val Trp Cys Pro Glu 
                85                  90                  95      


Ser Glu Ala His Ile Pro Leu Pro Pro Ala Pro Glu Gly Cys Pro Trp 
            100                 105                 110         


Ser Cys Arg Leu Leu Gly Ile Gly Gly His Leu Ser Pro Gln Gly Lys 
        115                 120                 125             


Leu Thr Leu Pro Glu Glu His Pro Cys Leu Lys Ala Pro Arg Leu Arg 
    130                 135                 140                 


Cys Gln Ser Cys Lys Leu Ala Gln Ala Pro Gly Leu Arg Ala Gly Glu 
145                 150                 155                 160 


Arg Ser Pro Glu Glu Ser Leu Gly Gly Arg Arg Lys Arg Asn Val Asn 
                165                 170                 175     


Thr Ala Pro Gln Phe Gln Pro Pro Ser Tyr Gln Ala Thr Val Pro Glu 
            180                 185                 190         


Asn Gln Pro Ala Gly Thr Pro Val Ala Ser Leu Arg Ala Ile Asp Pro 
        195                 200                 205             


Asp Glu Gly Glu Ala Gly Arg Leu Glu Tyr Thr Met Asp Ala Leu Phe 
    210                 215                 220                 


Asp Ser Arg Ser Asn Gln Phe Phe Ser Leu Asp Pro Val Thr Gly Ala 
225                 230                 235                 240 


Val Thr Thr Ala Glu Glu Leu Asp Arg Glu Thr Lys Ser Thr His Val 
                245                 250                 255     


Phe Arg Val Thr Ala Gln Asp His Gly Met Pro Arg Arg Ser Ala Leu 
            260                 265                 270         


Ala Thr Leu Thr Ile Leu Val Thr Asp Thr Asn Asp His Asp Pro Val 
        275                 280                 285             


Phe Glu Gln Gln Glu Tyr Lys Glu Ser Leu Arg Glu Asn Leu Glu Val 
    290                 295                 300                 


Gly Tyr Glu Val Leu Thr Val Arg Ala Thr Asp Gly Asp Ala Pro Pro 
305                 310                 315                 320 


Asn Ala Asn Ile Leu Tyr Arg Leu Leu Glu Gly Ser Gly Gly Ser Pro 
                325                 330                 335     


Ser Glu Val Phe Glu Ile Asp Pro Arg Ser Gly Val Ile Arg Thr Arg 
            340                 345                 350         


Gly Pro Val Asp Arg Glu Glu Val Glu Ser Tyr Gln Leu Thr Val Glu 
        355                 360                 365             


Ala Ser Asp Gln Gly Arg Asp Pro Gly Pro Arg Ser Thr Thr Ala Ala 
    370                 375                 380                 


Val Phe Leu Ser Val Glu Asp Asp Asn Asp Asn Ala Pro Gln Phe Ser 
385                 390                 395                 400 


Glu Lys Arg Tyr Val Val Gln Val Arg Glu Asp Val Thr Pro Gly Ala 
                405                 410                 415     


Pro Val Leu Arg Val Thr Ala Ser Asp Arg Asp Lys Gly Ser Asn Ala 
            420                 425                 430         


Val Val His Tyr Ser Ile Met Ser Gly Asn Ala Arg Gly Gln Phe Tyr 
        435                 440                 445             


Leu Asp Ala Gln Thr Gly Ala Leu Asp Val Val Ser Pro Leu Asp Tyr 
    450                 455                 460                 


Glu Thr Thr Lys Glu Tyr Thr Leu Arg Val Arg Ala Gln Asp Gly Gly 
465                 470                 475                 480 


Arg Pro Pro Leu Ser Asn Val Ser Gly Leu Val Thr Val Gln Val Leu 
                485                 490                 495     


Asp Ile Asn Asp Asn Ala Pro Ile Phe Val Ser Thr Pro Phe Gln Ala 
            500                 505                 510         


Thr Val Leu Glu Ser Val Pro Leu Gly Tyr Leu Val Leu His Val Gln 
        515                 520                 525             


Ala Ile Asp Ala Asp Ala Gly Asp Asn Ala Arg Leu Glu Tyr Arg Leu 
    530                 535                 540                 


Ala Gly Val Gly His Asp Phe Pro Phe Thr Ile Asn Asn Gly Thr Gly 
545                 550                 555                 560 


Trp Ile Ser Val Ala Ala Glu Leu Asp Arg Glu Glu Val Asp Phe Tyr 
                565                 570                 575     


Ser Phe Gly Val Glu Ala Arg Asp His Gly Thr Pro Ala Leu Thr Ala 
            580                 585                 590         


Ser Ala Ser Val Ser Val Thr Val Leu Asp Val Asn Asp Asn Asn Pro 
        595                 600                 605             


Thr Phe Thr Gln Pro Glu Tyr Thr Val Arg Leu Asn Glu Asp Ala Ala 
    610                 615                 620                 


Val Gly Thr Ser Val Val Thr Val Ser Ala Val Asp Arg Asp Ala His 
625                 630                 635                 640 


Ser Val Ile Thr Tyr Gln Ile Thr Ser Gly Asn Thr Arg Asn Arg Phe 
                645                 650                 655     


Ser Ile Thr Ser Gln Ser Gly Gly Gly Leu Val Ser Leu Ala Leu Pro 
            660                 665                 670         


Leu Asp Tyr Lys Leu Glu Arg Gln Tyr Val Leu Ala Val Thr Ala Ser 
        675                 680                 685             


Asp Gly Thr Arg Gln Asp Thr Ala Gln Ile Val Val Asn Val Thr Asp 
    690                 695                 700                 


Ala Asn Thr His Arg Pro Val Phe Gln Ser Ser His Tyr Thr Val Asn 
705                 710                 715                 720 


Val Asn Glu Asp Arg Pro Ala Gly Thr Thr Val Val Leu Ile Ser Ala 
                725                 730                 735     


Thr Asp Glu Asp Thr Gly Glu Asn Ala Arg Ile Thr Tyr Phe Met Glu 
            740                 745                 750         


Asp Ser Ile Pro Gln Phe Arg Ile Asp Ala Asp Thr Gly Ala Val Thr 
        755                 760                 765             


Thr Gln Ala Glu Leu Asp Tyr Glu Asp Gln Val Ser Tyr Thr Leu Ala 
    770                 775                 780                 


Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ser Asp Thr Thr Tyr 
785                 790                 795                 800 


Leu Glu Ile Leu Val Asn Asp Val Asn Asp Asn Ala Pro Gln Phe Leu 
                805                 810                 815     


Arg Asp Ser Tyr Gln Gly Ser Val Tyr Glu Asp Val Pro Pro Phe Thr 
            820                 825                 830         


Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ser Gly Leu Asn Gly 
        835                 840                 845             


Arg Val Phe Tyr Thr Phe Gln Gly Gly Asp Asp Gly Asp Gly Asp Phe 
    850                 855                 860                 


Ile Val Glu Ser Thr Ser Gly Ile Val Arg Thr Leu Arg Arg Leu Asp 
865                 870                 875                 880 


Arg Glu Asn Val Ala Gln Tyr Val Leu Arg Ala Tyr Ala Val Asp Lys 
                885                 890                 895     


Gly Met Pro Pro Ala Arg Thr Pro Met Glu Val Thr Val Thr Val Leu 
            900                 905                 910         


Asp Val Asn Asp Asn Pro Pro Val Phe Glu Gln Asp Glu Phe Asp Val 
        915                 920                 925             


Phe Val Glu Glu Asn Ser Pro Ile Gly Leu Ala Val Ala Arg Val Thr 
    930                 935                 940                 


Ala Thr Asp Pro Asp Glu Gly Thr Asn Ala Gln Ile Met Tyr Gln Ile 
945                 950                 955                 960 


Val Glu Gly Asn Ile Pro Glu Val Phe Gln Leu Asp Ile Phe Ser Gly 
                965                 970                 975     


Glu Leu Thr Ala Leu Val Asp Leu Asp Tyr Glu Asp Arg Pro Glu Tyr 
            980                 985                 990         


Val Leu Val Ile Gln Ala Thr Ser  Ala Pro Leu Val Ser  Arg Ala Thr 
        995                 1000                 1005             


Val His  Val Arg Leu Leu Asp  Arg Asn Asp Asn Pro  Pro Val Leu 
    1010                 1015                 1020             


Gly Asn  Phe Glu Ile Leu Phe  Asn Asn Tyr Val Thr  Asn Arg Ser 
    1025                 1030                 1035             


Ser Ser  Phe Pro Gly Gly Ala  Ile Gly Arg Val Pro  Ala His Asp 
    1040                 1045                 1050             


Pro Asp  Ile Ser Asp Ser Leu  Thr Tyr Ser Phe Glu  Arg Gly Asn 
    1055                 1060                 1065             


Glu Leu  Ser Leu Val Leu Leu  Asn Ala Ser Thr Gly  Glu Leu Lys 
    1070                 1075                 1080             


Leu Ser  Arg Ala Leu Asp Asn  Asn Arg Pro Leu Glu  Ala Ile Met 
    1085                 1090                 1095             


Ser Val  Leu Val Ser Asp Gly  Val His Ser Val Thr  Ala Gln Cys 
    1100                 1105                 1110             


Ala Leu  Arg Val Thr Ile Ile  Thr Asp Glu Met Leu  Thr His Ser 
    1115                 1120                 1125             


Ile Thr  Leu Arg Leu Glu Asp  Met Ser Pro Glu Arg  Phe Leu Ser 
    1130                 1135                 1140             


Pro Leu  Leu Gly Leu Phe Ile  Gln Ala Val Ala Ala  Thr Leu Ala 
    1145                 1150                 1155             


Thr Pro  Pro Asp His Val Val  Val Phe Asn Val Gln  Arg Asp Thr 
    1160                 1165                 1170             


Asp Ala  Pro Gly Gly His Ile  Leu Asn Val Ser Leu  Ser Val Gly 
    1175                 1180                 1185             


Gln Pro  Pro Gly Pro Gly Gly  Gly Pro Pro Phe Leu  Pro Ser Glu 
    1190                 1195                 1200             


Asp Leu  Gln Glu Arg Leu Tyr  Leu Asn Arg Ser Leu  Leu Thr Ala 
    1205                 1210                 1215             


Ile Ser  Ala Gln Arg Val Leu  Pro Phe Asp Asp Asn  Ile Cys Leu 
    1220                 1225                 1230             


Arg Glu  Pro Cys Glu Asn Tyr  Met Arg Cys Val Ser  Val Leu Arg 
    1235                 1240                 1245             


Phe Asp  Ser Ser Ala Pro Phe  Ile Ala Ser Ser Ser  Val Leu Phe 
    1250                 1255                 1260             


Arg Pro  Ile His Pro Val Gly  Gly Leu Arg Cys Arg  Cys Pro Pro 
    1265                 1270                 1275             


Gly Phe  Thr Gly Asp Tyr Cys  Glu Thr Glu Val Asp  Leu Cys Tyr 
    1280                 1285                 1290             


Ser Arg  Pro Cys Gly Pro His  Gly Arg Cys Arg Ser  Arg Glu Gly 
    1295                 1300                 1305             


Gly Tyr  Thr Cys Leu Cys Arg  Asp Gly Tyr Thr Gly  Glu His Cys 
    1310                 1315                 1320             


Glu Val  Ser Ala Arg Ser Gly  Arg Cys Thr Pro Gly  Val Cys Lys 
    1325                 1330                 1335             


Asn Gly  Gly Thr Cys Val Asn  Leu Leu Val Gly Gly  Phe Lys Cys 
    1340                 1345                 1350             


Asp Cys  Pro Ser Gly Asp Phe  Glu Lys Pro Tyr Cys  Gln Val Thr 
    1355                 1360                 1365             


Thr Arg  Ser Phe Pro Ala His  Ser Phe Ile Thr Phe  Arg Gly Leu 
    1370                 1375                 1380             


Arg Gln  Arg Phe His Phe Thr  Leu Ala Leu Ser Phe  Ala Thr Lys 
    1385                 1390                 1395             


Glu Arg  Asp Gly Leu Leu Leu  Tyr Asn Gly Arg Phe  Asn Glu Lys 
    1400                 1405                 1410             


His Asp  Phe Val Ala Leu Glu  Val Ile Gln Glu Gln  Val Gln Leu 
    1415                 1420                 1425             


Thr Phe  Ser Ala Gly Glu Ser  Thr Thr Thr Val Ser  Pro Phe Val 
    1430                 1435                 1440             


Pro Gly  Gly Val Ser Asp Gly  Gln Trp His Thr Val  Gln Leu Lys 
    1445                 1450                 1455             


Tyr Tyr  Asn Lys Pro Leu Leu  Gly Gln Thr Gly Leu  Pro Gln Gly 
    1460                 1465                 1470             


Pro Ser  Glu Gln Lys Val Ala  Val Val Thr Val Asp  Gly Cys Asp 
    1475                 1480                 1485             


Thr Gly  Val Ala Leu Arg Phe  Gly Ser Val Leu Gly  Asn Tyr Ser 
    1490                 1495                 1500             


Cys Ala  Ala Gln Gly Thr Gln  Gly Gly Ser Lys Lys  Ser Leu Asp 
    1505                 1510                 1515             


Leu Thr  Gly Pro Leu Leu Leu  Gly Gly Val Pro Asp  Leu Pro Glu 
    1520                 1525                 1530             


Ser Phe  Pro Val Arg Met Arg  Gln Phe Val Gly Cys  Met Arg Asn 
    1535                 1540                 1545             


Leu Gln  Val Asp Ser Arg His  Ile Asp Met Ala Asp  Phe Ile Ala 
    1550                 1555                 1560             


Asn Asn  Gly Thr Val Pro Gly  Cys Pro Ala Lys Lys  Asn Val Cys 
    1565                 1570                 1575             


Asp Ser  Asn Thr Cys His Asn  Gly Gly Thr Cys Val  Asn Gln Trp 
    1580                 1585                 1590             


Asp Ala  Phe Ser Cys Glu Cys  Pro Leu Gly Phe Gly  Gly Lys Ser 
    1595                 1600                 1605             


Cys Ala  Gln Glu Met Ala Asn  Pro Gln His Phe Leu  Gly Ser Ser 
    1610                 1615                 1620             


Leu Val  Ala Trp His Gly Leu  Ser Leu Pro Ile Ser  Gln Pro Trp 
    1625                 1630                 1635             


Tyr Leu  Ser Leu Met Phe Arg  Thr Arg Gln Ala Asp  Gly Val Leu 
    1640                 1645                 1650             


Leu Gln  Ala Ile Thr Arg Gly  Arg Ser Thr Ile Thr  Leu Gln Leu 
    1655                 1660                 1665             


Arg Glu  Gly His Val Met Leu  Ser Val Glu Gly Thr  Gly Leu Gln 
    1670                 1675                 1680             


Ala Ser  Ser Leu Arg Leu Glu  Pro Gly Arg Ala Asn  Asp Gly Asp 
    1685                 1690                 1695             


Trp His  His Ala Gln Leu Ala  Leu Gly Ala Ser Gly  Gly Pro Gly 
    1700                 1705                 1710             


His Ala  Ile Leu Ser Phe Asp  Tyr Gly Gln Gln Arg  Ala Glu Gly 
    1715                 1720                 1725             


Asn Leu  Gly Pro Arg Leu His  Gly Leu His Leu Ser  Asn Ile Thr 
    1730                 1735                 1740             


Val Gly  Gly Ile Pro Gly Pro  Ala Gly Gly Val Ala  Arg Gly Phe 
    1745                 1750                 1755             


Arg Gly  Cys Leu Gln Gly Val  Arg Val Ser Asp Thr  Pro Glu Gly 
    1760                 1765                 1770             


Val Asn  Ser Leu Asp Pro Ser  His Gly Glu Ser Ile  Asn Val Glu 
    1775                 1780                 1785             


Gln Gly  Cys Ser Leu Pro Asp  Pro Cys Asp Ser Asn  Pro Cys Pro 
    1790                 1795                 1800             


Ala Asn  Ser Tyr Cys Ser Asn  Asp Trp Asp Ser Tyr  Ser Cys Ser 
    1805                 1810                 1815             


Cys Asp  Pro Gly Tyr Tyr Gly  Asp Asn Cys Thr Asn  Val Cys Asp 
    1820                 1825                 1830             


Leu Asn  Pro Cys Glu His Gln  Ser Val Cys Thr Arg  Lys Pro Ser 
    1835                 1840                 1845             


Ala Pro  His Gly Tyr Thr Cys  Glu Cys Pro Pro Asn  Tyr Leu Gly 
    1850                 1855                 1860             


Pro Tyr  Cys Glu Thr Arg Ile  Asp Gln Pro Cys Pro  Arg Gly Trp 
    1865                 1870                 1875             


Trp Gly  His Pro Thr Cys Gly  Pro Cys Asn Cys Asp  Val Ser Lys 
    1880                 1885                 1890             


Gly Phe  Asp Pro Asp Cys Asn  Lys Thr Ser Gly Glu  Cys His Cys 
    1895                 1900                 1905             


Lys Glu  Asn His Tyr Arg Pro  Pro Gly Ser Pro Thr  Cys Leu Leu 
    1910                 1915                 1920             


Cys Asp  Cys Tyr Pro Thr Gly  Ser Leu Ser Arg Val  Cys Asp Pro 
    1925                 1930                 1935             


Glu Asp  Gly Gln Cys Pro Cys  Lys Pro Gly Val Ile  Gly Arg Gln 
    1940                 1945                 1950             


Cys Asp  Arg Cys Asp Asn Pro  Phe Ala Glu Val Thr  Thr Asn Gly 
    1955                 1960                 1965             


Cys Glu  Val Asn Tyr Asp Ser  Cys Pro Arg Ala Ile  Glu Ala Gly 
    1970                 1975                 1980             


Ile Trp  Trp Pro Arg Thr Arg  Phe Gly Leu Pro Ala  Ala Ala Pro 
    1985                 1990                 1995             


Cys Pro  Lys Gly Ser Phe Gly  Thr Ala Val Arg His  Cys Asp Glu 
    2000                 2005                 2010             


His Arg  Gly Trp Leu Pro Pro  Asn Leu Phe Asn Cys  Thr Ser Ile 
    2015                 2020                 2025             


Thr Phe  Ser Glu Leu Lys Gly  Phe Ala Glu Arg Leu  Gln Arg Asn 
    2030                 2035                 2040             


Glu Ser  Gly Leu Asp Ser Gly  Arg Ser Gln Gln Leu  Ala Leu Leu 
    2045                 2050                 2055             


Leu Arg  Asn Ala Thr Gln His  Thr Ala Gly Tyr Phe  Gly Ser Asp 
    2060                 2065                 2070             


Val Lys  Val Ala Tyr Gln Leu  Ala Thr Arg Leu Leu  Ala His Glu 
    2075                 2080                 2085             


Ser Thr  Gln Arg Gly Phe Gly  Leu Ser Ala Thr Gln  Asp Val His 
    2090                 2095                 2100             


Phe Thr  Glu Asn Leu Leu Arg  Val Gly Ser Ala Leu  Leu Asp Thr 
    2105                 2110                 2115             


Ala Asn  Lys Arg His Trp Glu  Leu Ile Gln Gln Thr  Glu Gly Gly 
    2120                 2125                 2130             


Thr Ala  Trp Leu Leu Gln His  Tyr Glu Ala Tyr Ala  Ser Ala Leu 
    2135                 2140                 2145             


Ala Gln  Asn Met Arg His Thr  Tyr Leu Ser Pro Phe  Thr Ile Val 
    2150                 2155                 2160             


Thr Pro  Asn Ile Val Ile Ser  Val Val Arg Leu Asp  Lys Gly Asn 
    2165                 2170                 2175             


Phe Ala  Gly Ala Lys Leu Pro  Arg Tyr Glu Ala Leu  Arg Gly Glu 
    2180                 2185                 2190             


Gln Pro  Pro Asp Leu Glu Thr  Thr Val Ile Leu Pro  Glu Ser Val 
    2195                 2200                 2205             


Phe Arg  Glu Thr Pro Pro Val  Val Arg Pro Ala Gly  Pro Gly Glu 
    2210                 2215                 2220             


Ala Gln  Glu Pro Glu Glu Leu  Ala Arg Arg Gln Arg  Arg His Pro 
    2225                 2230                 2235             


Glu Leu  Ser Gln Gly Glu Ala  Val Ala Ser Val Ile  Ile Tyr Arg 
    2240                 2245                 2250             


Thr Leu  Ala Gly Leu Leu Pro  His Asn Tyr Asp Pro  Asp Lys Arg 
    2255                 2260                 2265             


Ser Leu  Arg Val Pro Lys Arg  Pro Ile Ile Asn Thr  Pro Val Val 
    2270                 2275                 2280             


Ser Ile  Ser Val His Asp Asp  Glu Glu Leu Leu Pro  Arg Ala Leu 
    2285                 2290                 2295             


Asp Lys  Pro Val Thr Val Gln  Phe Arg Leu Leu Glu  Thr Glu Glu 
    2300                 2305                 2310             


Arg Thr  Lys Pro Ile Cys Val  Phe Trp Asn His Ser  Ile Leu Val 
    2315                 2320                 2325             


Ser Gly  Thr Gly Gly Trp Ser  Ala Arg Gly Cys Glu  Val Val Phe 
    2330                 2335                 2340             


Arg Asn  Glu Ser His Val Ser  Cys Gln Cys Asn His  Met Thr Ser 
    2345                 2350                 2355             


Phe Ala  Val Leu Met Asp Val  Ser Arg Arg Glu Asn  Gly Glu Ile 
    2360                 2365                 2370             


Leu Pro  Leu Lys Thr Leu Thr  Tyr Val Ala Leu Gly  Val Thr Leu 
    2375                 2380                 2385             


Ala Ala  Leu Leu Leu Thr Phe  Phe Phe Leu Thr Leu  Leu Arg Ile 
    2390                 2395                 2400             


Leu Arg  Ser Asn Gln His Gly  Ile Arg Arg Asn Leu  Thr Ala Ala 
    2405                 2410                 2415             


Leu Gly  Leu Ala Gln Leu Val  Phe Leu Leu Gly Ile  Asn Gln Ala 
    2420                 2425                 2430             


Asp Leu  Pro Phe Ala Cys Thr  Val Ile Ala Ile Leu  Leu His Phe 
    2435                 2440                 2445             


Leu Tyr  Leu Cys Thr Phe Ser  Trp Ala Leu Leu Glu  Ala Leu His 
    2450                 2455                 2460             


Leu Tyr  Arg Ala Leu Thr Glu  Val Arg Asp Val Asn  Thr Gly Pro 
    2465                 2470                 2475             


Met Arg  Phe Tyr Tyr Met Leu  Gly Trp Gly Val Pro  Ala Phe Ile 
    2480                 2485                 2490             


Thr Gly  Leu Ala Val Gly Leu  Asp Pro Glu Gly Tyr  Gly Asn Pro 
    2495                 2500                 2505             


Asp Phe  Cys Trp Leu Ser Ile  Tyr Asp Thr Leu Ile  Trp Ser Phe 
    2510                 2515                 2520             


Ala Gly  Pro Val Ala Phe Ala  Val Ser Met Ser Val  Phe Leu Tyr 
    2525                 2530                 2535             


Ile Leu  Ala Ala Arg Ala Ser  Cys Ala Ala Gln Arg  Gln Gly Phe 
    2540                 2545                 2550             


Glu Lys  Lys Gly Pro Val Ser  Gly Leu Gln Pro Ser  Phe Ala Val 
    2555                 2560                 2565             


Leu Leu  Leu Leu Ser Ala Thr  Trp Leu Leu Ala Leu  Leu Ser Val 
    2570                 2575                 2580             


Asn Ser  Asp Thr Leu Leu Phe  His Tyr Leu Phe Ala  Thr Cys Asn 
    2585                 2590                 2595             


Cys Ile  Gln Gly Pro Phe Ile  Phe Leu Ser Tyr Val  Val Leu Ser 
    2600                 2605                 2610             


Lys Glu  Val Arg Lys Ala Leu  Lys Leu Ala Cys Ser  Arg Lys Pro 
    2615                 2620                 2625             


Ser Pro  Asp Pro Ala Leu Thr  Thr Lys Ser Thr Leu  Thr Ser Ser 
    2630                 2635                 2640             


Tyr Asn  Cys Pro Ser Pro Tyr  Ala Asp Gly Arg Leu  Tyr Gln Pro 
    2645                 2650                 2655             


Tyr Gly  Asp Ser Ala Gly Ser  Leu His Ser Thr Ser  Arg Ser Gly 
    2660                 2665                 2670             


Lys Ser  Gln Pro Ser Tyr Ile  Pro Phe Leu Leu Arg  Glu Glu Ser 
    2675                 2680                 2685             


Ala Leu  Asn Pro Gly Gln Gly  Pro Pro Gly Leu Gly  Asp Pro Gly 
    2690                 2695                 2700             


Ser Leu  Phe Leu Glu Gly Gln  Asp Gln Gln His Asp  Pro Asp Thr 
    2705                 2710                 2715             


Asp Ser  Asp Ser Asp Leu Ser  Leu Glu Asp Asp Gln  Ser Gly Ser 
    2720                 2725                 2730             


Tyr Ala  Ser Thr His Ser Ser  Asp Ser Glu Glu Glu  Glu Glu Glu 
    2735                 2740                 2745             


Glu Glu  Glu Glu Ala Ala Phe  Pro Gly Glu Gln Gly  Trp Asp Ser 
    2750                 2755                 2760             


Leu Leu  Gly Pro Gly Ala Glu  Arg Leu Pro Leu His  Ser Thr Pro 
    2765                 2770                 2775             


Lys Asp  Gly Gly Pro Gly Pro  Gly Lys Ala Pro Trp  Pro Gly Asp 
    2780                 2785                 2790             


Phe Gly  Thr Thr Ala Lys Glu  Ser Ser Gly Asn Gly  Ala Pro Glu 
    2795                 2800                 2805             


Glu Arg  Leu Arg Glu Asn Gly  Asp Ala Leu Ser Arg  Glu Gly Ser 
    2810                 2815                 2820             


Leu Gly  Pro Leu Pro Gly Ser  Ser Ala Gln Pro His  Lys Gly Ile 
    2825                 2830                 2835             


Leu Lys  Lys Lys Cys Leu Pro  Thr Ile Ser Glu Lys  Ser Ser Leu 
    2840                 2845                 2850             


Leu Arg  Leu Pro Leu Glu Gln  Cys Thr Gly Ser Ser  Arg Gly Ser 
    2855                 2860                 2865             


Ser Ala  Ser Glu Gly Ser Arg  Gly Gly Pro Pro Pro  Arg Pro Pro 
    2870                 2875                 2880             


Pro Arg  Gln Ser Leu Gln Glu  Gln Leu Asn Gly Val  Met Pro Ile 
    2885                 2890                 2895             


Ala Met  Ser Ile Lys Ala Gly  Thr Val Asp Glu Asp  Ser Ser Gly 
    2900                 2905                 2910             


Ser Glu  Phe Leu Phe Phe Asn  Phe Leu His 
    2915                 2920             


<210>  30
<211>  3312
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Met Ala Arg Arg Pro Pro Trp Arg Gly Leu Gly Gly Arg Ser Thr 
1               5                   10                  15      


Pro Ile Leu Leu Leu Leu Leu Leu Ser Leu Phe Pro Leu Ser Gln Glu 
            20                  25                  30          


Glu Leu Gly Gly Gly Gly His Gln Gly Trp Asp Pro Gly Leu Ala Ala 
        35                  40                  45              


Thr Thr Gly Pro Arg Ala His Ile Gly Gly Gly Ala Leu Ala Leu Cys 
    50                  55                  60                  


Pro Glu Ser Ser Gly Val Arg Glu Asp Gly Gly Pro Gly Leu Gly Val 
65                  70                  75                  80  


Arg Glu Pro Ile Phe Val Gly Leu Arg Gly Arg Arg Gln Ser Ala Arg 
                85                  90                  95      


Asn Ser Arg Gly Pro Pro Glu Gln Pro Asn Glu Glu Leu Gly Ile Glu 
            100                 105                 110         


His Gly Val Gln Pro Leu Gly Ser Arg Glu Arg Glu Thr Gly Gln Gly 
        115                 120                 125             


Pro Gly Ser Val Leu Tyr Trp Arg Pro Glu Val Ser Ser Cys Gly Arg 
    130                 135                 140                 


Thr Gly Pro Leu Gln Arg Gly Ser Leu Ser Pro Gly Ala Leu Ser Ser 
145                 150                 155                 160 


Gly Val Pro Gly Ser Gly Asn Ser Ser Pro Leu Pro Ser Asp Phe Leu 
                165                 170                 175     


Ile Arg His His Gly Pro Lys Pro Val Ser Ser Gln Arg Asn Ala Gly 
            180                 185                 190         


Thr Gly Ser Arg Lys Arg Val Gly Thr Ala Arg Cys Cys Gly Glu Leu 
        195                 200                 205             


Trp Ala Thr Gly Ser Lys Gly Gln Gly Glu Arg Ala Thr Thr Ser Gly 
    210                 215                 220                 


Ala Glu Arg Thr Ala Pro Arg Arg Asn Cys Leu Pro Gly Ala Ser Gly 
225                 230                 235                 240 


Ser Gly Pro Glu Leu Asp Ser Ala Pro Arg Thr Ala Arg Thr Ala Pro 
                245                 250                 255     


Ala Ser Gly Ser Ala Pro Arg Glu Ser Arg Thr Ala Pro Glu Pro Ala 
            260                 265                 270         


Pro Lys Arg Met Arg Ser Arg Gly Leu Phe Arg Cys Arg Phe Leu Pro 
        275                 280                 285             


Gln Arg Pro Gly Pro Arg Pro Pro Gly Leu Pro Ala Arg Pro Glu Ala 
    290                 295                 300                 


Arg Lys Val Thr Ser Ala Asn Arg Ala Arg Phe Arg Arg Ala Ala Asn 
305                 310                 315                 320 


Arg His Pro Gln Phe Pro Gln Tyr Asn Tyr Gln Thr Leu Val Pro Glu 
                325                 330                 335     


Asn Glu Ala Ala Gly Thr Ala Val Leu Arg Val Val Ala Gln Asp Pro 
            340                 345                 350         


Asp Ala Gly Glu Ala Gly Arg Leu Val Tyr Ser Leu Ala Ala Leu Met 
        355                 360                 365             


Asn Ser Arg Ser Leu Glu Leu Phe Ser Ile Asp Pro Gln Ser Gly Leu 
    370                 375                 380                 


Ile Arg Thr Ala Ala Ala Leu Asp Arg Glu Ser Met Glu Arg His Tyr 
385                 390                 395                 400 


Leu Arg Val Thr Ala Gln Asp His Gly Ser Pro Arg Leu Ser Ala Thr 
                405                 410                 415     


Thr Met Val Ala Val Thr Val Ala Asp Arg Asn Asp His Ser Pro Val 
            420                 425                 430         


Phe Glu Gln Ala Gln Tyr Arg Glu Thr Leu Arg Glu Asn Val Glu Glu 
        435                 440                 445             


Gly Tyr Pro Ile Leu Gln Leu Arg Ala Thr Asp Gly Asp Ala Pro Pro 
    450                 455                 460                 


Asn Ala Asn Leu Arg Tyr Arg Phe Val Gly Pro Pro Ala Ala Arg Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Ala Phe Glu Ile Asp Pro Arg Ser Gly Leu Ile Ser 
                485                 490                 495     


Thr Ser Gly Arg Val Asp Arg Glu His Met Glu Ser Tyr Glu Leu Val 
            500                 505                 510         


Val Glu Ala Ser Asp Gln Gly Gln Glu Pro Gly Pro Arg Ser Ala Thr 
        515                 520                 525             


Val Arg Val His Ile Thr Val Leu Asp Glu Asn Asp Asn Ala Pro Gln 
    530                 535                 540                 


Phe Ser Glu Lys Arg Tyr Val Ala Gln Val Arg Glu Asp Val Arg Pro 
545                 550                 555                 560 


His Thr Val Val Leu Arg Val Thr Ala Thr Asp Arg Asp Lys Asp Ala 
                565                 570                 575     


Asn Gly Leu Val His Tyr Asn Ile Ile Ser Gly Asn Ser Arg Gly His 
            580                 585                 590         


Phe Ala Ile Asp Ser Leu Thr Gly Glu Ile Gln Val Val Ala Pro Leu 
        595                 600                 605             


Asp Phe Glu Ala Glu Arg Glu Tyr Ala Leu Arg Ile Arg Ala Gln Asp 
    610                 615                 620                 


Ala Gly Arg Pro Pro Leu Ser Asn Asn Thr Gly Leu Ala Ser Ile Gln 
625                 630                 635                 640 


Val Val Asp Ile Asn Asp His Ile Pro Ile Phe Val Ser Thr Pro Phe 
                645                 650                 655     


Gln Val Ser Val Leu Glu Asn Ala Pro Leu Gly His Ser Val Ile His 
            660                 665                 670         


Ile Gln Ala Val Asp Ala Asp His Gly Glu Asn Ala Arg Leu Glu Tyr 
        675                 680                 685             


Ser Leu Thr Gly Val Ala Pro Asp Thr Pro Phe Val Ile Asn Ser Ala 
    690                 695                 700                 


Thr Gly Trp Val Ser Val Ser Gly Pro Leu Asp Arg Glu Ser Val Glu 
705                 710                 715                 720 


His Tyr Phe Phe Gly Val Glu Ala Arg Asp His Gly Ser Pro Pro Leu 
                725                 730                 735     


Ser Ala Ser Ala Ser Val Thr Val Thr Val Leu Asp Val Asn Asp Asn 
            740                 745                 750         


Arg Pro Glu Phe Thr Met Lys Glu Tyr His Leu Arg Leu Asn Glu Asp 
        755                 760                 765             


Ala Ala Val Gly Thr Ser Val Val Ser Val Thr Ala Val Asp Arg Asp 
    770                 775                 780                 


Ala Asn Ser Ala Ile Ser Tyr Gln Ile Thr Gly Gly Asn Thr Arg Asn 
785                 790                 795                 800 


Arg Phe Ala Ile Ser Thr Gln Gly Gly Val Gly Leu Val Thr Leu Ala 
                805                 810                 815     


Leu Pro Leu Asp Tyr Lys Gln Glu Arg Tyr Phe Lys Leu Val Leu Thr 
            820                 825                 830         


Ala Ser Asp Arg Ala Leu His Asp His Cys Tyr Val His Ile Asn Ile 
        835                 840                 845             


Thr Asp Ala Asn Thr His Arg Pro Val Phe Gln Ser Ala His Tyr Ser 
    850                 855                 860                 


Val Ser Val Asn Glu Asp Arg Pro Met Gly Ser Thr Ile Val Val Ile 
865                 870                 875                 880 


Ser Ala Ser Asp Asp Asp Val Gly Glu Asn Ala Arg Ile Thr Tyr Leu 
                885                 890                 895     


Leu Glu Asp Asn Leu Pro Gln Phe Arg Ile Asp Ala Asp Ser Gly Ala 
            900                 905                 910         


Ile Thr Leu Gln Ala Pro Leu Asp Tyr Glu Asp Gln Val Thr Tyr Thr 
        915                 920                 925             


Leu Ala Ile Thr Ala Arg Asp Asn Gly Ile Pro Gln Lys Ala Asp Thr 
    930                 935                 940                 


Thr Tyr Val Glu Val Met Val Asn Asp Val Asn Asp Asn Ala Pro Gln 
945                 950                 955                 960 


Phe Val Ala Ser His Tyr Thr Gly Leu Val Ser Glu Asp Ala Pro Pro 
                965                 970                 975     


Phe Thr Ser Val Leu Gln Ile Ser Ala Thr Asp Arg Asp Ala His Ala 
            980                 985                 990         


Asn Gly Arg Val Gln Tyr Thr Phe  Gln Asn Gly Glu Asp  Gly Asp Gly 
        995                 1000                 1005             


Asp Phe  Thr Ile Glu Pro Thr  Ser Gly Ile Val Arg  Thr Val Arg 
    1010                 1015                 1020             


Arg Leu  Asp Arg Glu Ala Val  Ser Val Tyr Glu Leu  Thr Ala Tyr 
    1025                 1030                 1035             


Ala Val  Asp Arg Gly Val Pro  Pro Leu Arg Thr Pro  Val Ser Ile 
    1040                 1045                 1050             


Gln Val  Met Val Gln Asp Val  Asn Asp Asn Ala Pro  Val Phe Pro 
    1055                 1060                 1065             


Ala Glu  Glu Phe Glu Val Arg  Val Lys Glu Asn Ser  Ile Val Gly 
    1070                 1075                 1080             


Ser Val  Val Ala Gln Ile Thr  Ala Val Asp Pro Asp  Glu Gly Pro 
    1085                 1090                 1095             


Asn Ala  His Ile Met Tyr Gln  Ile Val Glu Gly Asn  Ile Pro Glu 
    1100                 1105                 1110             


Leu Phe  Gln Met Asp Ile Phe  Ser Gly Glu Leu Thr  Ala Leu Ile 
    1115                 1120                 1125             


Asp Leu  Asp Tyr Glu Ala Arg  Gln Glu Tyr Val Ile  Val Val Gln 
    1130                 1135                 1140             


Ala Thr  Ser Ala Pro Leu Val  Ser Arg Ala Thr Val  His Val Arg 
    1145                 1150                 1155             


Leu Val  Asp Gln Asn Asp Asn  Ser Pro Val Leu Asn  Asn Phe Gln 
    1160                 1165                 1170             


Ile Leu  Phe Asn Asn Tyr Val  Ser Asn Arg Ser Asp  Thr Phe Pro 
    1175                 1180                 1185             


Ser Gly  Ile Ile Gly Arg Ile  Pro Ala Tyr Asp Pro  Asp Val Ser 
    1190                 1195                 1200             


Asp His  Leu Phe Tyr Ser Phe  Glu Arg Gly Asn Glu  Leu Gln Leu 
    1205                 1210                 1215             


Leu Val  Val Asn Gln Thr Ser  Gly Glu Leu Arg Leu  Ser Arg Lys 
    1220                 1225                 1230             


Leu Asp  Asn Asn Arg Pro Leu  Val Ala Ser Met Leu  Val Thr Val 
    1235                 1240                 1245             


Thr Asp  Gly Leu His Ser Val  Thr Ala Gln Cys Val  Leu Arg Val 
    1250                 1255                 1260             


Val Ile  Ile Thr Glu Glu Leu  Leu Ala Asn Ser Leu  Thr Val Arg 
    1265                 1270                 1275             


Leu Glu  Asn Met Trp Gln Glu  Arg Phe Leu Ser Pro  Leu Leu Gly 
    1280                 1285                 1290             


Arg Phe  Leu Glu Gly Val Ala  Ala Val Leu Ala Thr  Pro Ala Glu 
    1295                 1300                 1305             


Asp Val  Phe Ile Phe Asn Ile  Gln Asn Asp Thr Asp  Val Gly Gly 
    1310                 1315                 1320             


Thr Val  Leu Asn Val Ser Phe  Ser Ala Leu Ala Pro  Arg Gly Ala 
    1325                 1330                 1335             


Gly Ala  Gly Ala Ala Gly Pro  Trp Phe Ser Ser Glu  Glu Leu Gln 
    1340                 1345                 1350             


Glu Gln  Leu Tyr Val Arg Arg  Ala Ala Leu Ala Ala  Arg Ser Leu 
    1355                 1360                 1365             


Leu Asp  Val Leu Pro Phe Asp  Asp Asn Val Cys Leu  Arg Glu Pro 
    1370                 1375                 1380             


Cys Glu  Asn Tyr Met Lys Cys  Val Ser Val Leu Arg  Phe Asp Ser 
    1385                 1390                 1395             


Ser Ala  Pro Phe Leu Ala Ser  Ala Ser Thr Leu Phe  Arg Pro Ile 
    1400                 1405                 1410             


Gln Pro  Ile Ala Gly Leu Arg  Cys Arg Cys Pro Pro  Gly Phe Thr 
    1415                 1420                 1425             


Gly Asp  Phe Cys Glu Thr Glu  Leu Asp Leu Cys Tyr  Ser Asn Pro 
    1430                 1435                 1440             


Cys Arg  Asn Gly Gly Ala Cys  Ala Arg Arg Glu Gly  Gly Tyr Thr 
    1445                 1450                 1455             


Cys Val  Cys Arg Pro Arg Phe  Thr Gly Glu Asp Cys  Glu Leu Asp 
    1460                 1465                 1470             


Thr Glu  Ala Gly Arg Cys Val  Pro Gly Val Cys Arg  Asn Gly Gly 
    1475                 1480                 1485             


Thr Cys  Thr Asp Ala Pro Asn  Gly Gly Phe Arg Cys  Gln Cys Pro 
    1490                 1495                 1500             


Ala Gly  Gly Ala Phe Glu Gly  Pro Arg Cys Glu Val  Ala Ala Arg 
    1505                 1510                 1515             


Ser Phe  Pro Pro Ser Ser Phe  Val Met Phe Arg Gly  Leu Arg Gln 
    1520                 1525                 1530             


Arg Phe  His Leu Thr Leu Ser  Leu Ser Phe Ala Thr  Val Gln Gln 
    1535                 1540                 1545             


Ser Gly  Leu Leu Phe Tyr Asn  Gly Arg Leu Asn Glu  Lys His Asp 
    1550                 1555                 1560             


Phe Leu  Ala Leu Glu Leu Val  Ala Gly Gln Val Arg  Leu Thr Tyr 
    1565                 1570                 1575             


Ser Thr  Gly Glu Ser Asn Thr  Val Val Ser Pro Thr  Val Pro Gly 
    1580                 1585                 1590             


Gly Leu  Ser Asp Gly Gln Trp  His Thr Val His Leu  Arg Tyr Tyr 
    1595                 1600                 1605             


Asn Lys  Pro Arg Thr Asp Ala  Leu Gly Gly Ala Gln  Gly Pro Ser 
    1610                 1615                 1620             


Lys Asp  Lys Val Ala Val Leu  Ser Val Asp Asp Cys  Asp Val Ala 
    1625                 1630                 1635             


Val Ala  Leu Gln Phe Gly Ala  Glu Ile Gly Asn Tyr  Ser Cys Ala 
    1640                 1645                 1650             


Ala Ala  Gly Val Gln Thr Ser  Ser Lys Lys Ser Leu  Asp Leu Thr 
    1655                 1660                 1665             


Gly Pro  Leu Leu Leu Gly Gly  Val Pro Asn Leu Pro  Glu Asn Phe 
    1670                 1675                 1680             


Pro Val  Ser His Lys Asp Phe  Ile Gly Cys Met Arg  Asp Leu His 
    1685                 1690                 1695             


Ile Asp  Gly Arg Arg Val Asp  Met Ala Ala Phe Val  Ala Asn Asn 
    1700                 1705                 1710             


Gly Thr  Met Ala Gly Cys Gln  Ala Lys Leu His Phe  Cys Asp Ser 
    1715                 1720                 1725             


Gly Pro  Cys Lys Asn Ser Gly  Phe Cys Ser Glu Arg  Trp Gly Ser 
    1730                 1735                 1740             


Phe Ser  Cys Asp Cys Pro Val  Gly Phe Gly Gly Lys  Asp Cys Gln 
    1745                 1750                 1755             


Leu Thr  Met Ala His Pro His  His Phe Arg Gly Asn  Gly Thr Leu 
    1760                 1765                 1770             


Ser Trp  Asn Phe Gly Ser Asp  Met Ala Val Ser Val  Pro Trp Tyr 
    1775                 1780                 1785             


Leu Gly  Leu Ala Phe Arg Thr  Arg Ala Thr Gln Gly  Val Leu Met 
    1790                 1795                 1800             


Gln Val  Gln Ala Gly Pro His  Ser Thr Leu Leu Cys  Gln Leu Asp 
    1805                 1810                 1815             


Arg Gly  Leu Leu Ser Val Thr  Val Thr Arg Gly Ser  Gly Arg Ala 
    1820                 1825                 1830             


Ser His  Leu Leu Leu Asp Gln  Val Thr Val Ser Asp  Gly Arg Trp 
    1835                 1840                 1845             


His Asp  Leu Arg Leu Glu Leu  Gln Glu Glu Pro Gly  Gly Arg Arg 
    1850                 1855                 1860             


Gly His  His Val Leu Met Val  Ser Leu Asp Phe Ser  Leu Phe Gln 
    1865                 1870                 1875             


Asp Thr  Met Ala Val Gly Ser  Glu Leu Gln Gly Leu  Lys Val Lys 
    1880                 1885                 1890             


Gln Leu  His Val Gly Gly Leu  Pro Pro Gly Ser Ala  Glu Glu Ala 
    1895                 1900                 1905             


Pro Gln  Gly Leu Val Gly Cys  Ile Gln Gly Val Trp  Leu Gly Ser 
    1910                 1915                 1920             


Thr Pro  Ser Gly Ser Pro Ala  Leu Leu Pro Pro Ser  His Arg Val 
    1925                 1930                 1935             


Asn Ala  Glu Pro Gly Cys Val  Val Thr Asn Ala Cys  Ala Ser Gly 
    1940                 1945                 1950             


Pro Cys  Pro Pro His Ala Asp  Cys Arg Asp Leu Trp  Gln Thr Phe 
    1955                 1960                 1965             


Ser Cys  Thr Cys Gln Pro Gly  Tyr Tyr Gly Pro Gly  Cys Val Asp 
    1970                 1975                 1980             


Ala Cys  Leu Leu Asn Pro Cys  Gln Asn Gln Gly Ser  Cys Arg His 
    1985                 1990                 1995             


Leu Pro  Gly Ala Pro His Gly  Tyr Thr Cys Asp Cys  Val Gly Gly 
    2000                 2005                 2010             


Tyr Phe  Gly His His Cys Glu  His Arg Met Asp Gln  Gln Cys Pro 
    2015                 2020                 2025             


Arg Gly  Trp Trp Gly Ser Pro  Thr Cys Gly Pro Cys  Asn Cys Asp 
    2030                 2035                 2040             


Val His  Lys Gly Phe Asp Pro  Asn Cys Asn Lys Thr  Asn Gly Gln 
    2045                 2050                 2055             


Cys His  Cys Lys Glu Phe His  Tyr Arg Pro Arg Gly  Ser Asp Ser 
    2060                 2065                 2070             


Cys Leu  Pro Cys Asp Cys Tyr  Pro Val Gly Ser Thr  Ser Arg Ser 
    2075                 2080                 2085             


Cys Ala  Pro His Ser Gly Gln  Cys Pro Cys Arg Pro  Gly Ala Leu 
    2090                 2095                 2100             


Gly Arg  Gln Cys Asn Ser Cys  Asp Ser Pro Phe Ala  Glu Val Thr 
    2105                 2110                 2115             


Ala Ser  Gly Cys Arg Val Leu  Tyr Asp Ala Cys Pro  Lys Ser Leu 
    2120                 2125                 2130             


Arg Ser  Gly Val Trp Trp Pro  Gln Thr Lys Phe Gly  Val Leu Ala 
    2135                 2140                 2145             


Thr Val  Pro Cys Pro Arg Gly  Ala Leu Gly Ala Ala  Val Arg Leu 
    2150                 2155                 2160             


Cys Asp  Glu Ala Gln Gly Trp  Leu Glu Pro Asp Leu  Phe Asn Cys 
    2165                 2170                 2175             


Thr Ser  Pro Ala Phe Arg Glu  Leu Ser Leu Leu Leu  Asp Gly Leu 
    2180                 2185                 2190             


Glu Leu  Asn Lys Thr Ala Leu  Asp Thr Met Glu Ala  Lys Lys Leu 
    2195                 2200                 2205             


Ala Gln  Arg Leu Arg Glu Val  Thr Gly His Thr Asp  His Tyr Phe 
    2210                 2215                 2220             


Ser Gln  Asp Val Arg Val Thr  Ala Arg Leu Leu Ala  His Leu Leu 
    2225                 2230                 2235             


Ala Phe  Glu Ser His Gln Gln  Gly Phe Gly Leu Thr  Ala Thr Gln 
    2240                 2245                 2250             


Asp Ala  His Phe Asn Glu Asn  Leu Leu Trp Ala Gly  Ser Ala Leu 
    2255                 2260                 2265             


Leu Ala  Pro Glu Thr Gly Asp  Leu Trp Ala Ala Leu  Gly Gln Arg 
    2270                 2275                 2280             


Ala Pro  Gly Gly Ser Pro Gly  Ser Ala Gly Leu Val  Arg His Leu 
    2285                 2290                 2295             


Glu Glu  Tyr Ala Ala Thr Leu  Ala Arg Asn Met Glu  Leu Thr Tyr 
    2300                 2305                 2310             


Leu Asn  Pro Met Gly Leu Val  Thr Pro Asn Ile Met  Leu Ser Ile 
    2315                 2320                 2325             


Asp Arg  Met Glu His Pro Ser  Ser Pro Arg Gly Ala  Arg Arg Tyr 
    2330                 2335                 2340             


Pro Arg  Tyr His Ser Asn Leu  Phe Arg Gly Gln Asp  Ala Trp Asp 
    2345                 2350                 2355             


Pro His  Thr His Val Leu Leu  Pro Ser Gln Ser Pro  Arg Pro Ser 
    2360                 2365                 2370             


Pro Ser  Glu Val Leu Pro Thr  Ser Ser Ser Ile Glu  Asn Ser Thr 
    2375                 2380                 2385             


Thr Ser  Ser Val Val Pro Pro  Pro Ala Pro Pro Glu  Pro Glu Pro 
    2390                 2395                 2400             


Gly Ile  Ser Ile Ile Ile Leu  Leu Val Tyr Arg Thr  Leu Gly Gly 
    2405                 2410                 2415             


Leu Leu  Pro Ala Gln Phe Gln  Ala Glu Arg Arg Gly  Ala Arg Leu 
    2420                 2425                 2430             


Pro Gln  Asn Pro Val Met Asn  Ser Pro Val Val Ser  Val Ala Val 
    2435                 2440                 2445             


Phe His  Gly Arg Asn Phe Leu  Arg Gly Ile Leu Glu  Ser Pro Ile 
    2450                 2455                 2460             


Ser Leu  Glu Phe Arg Leu Leu  Gln Thr Ala Asn Arg  Ser Lys Ala 
    2465                 2470                 2475             


Ile Cys  Val Gln Trp Asp Pro  Pro Gly Leu Ala Glu  Gln His Gly 
    2480                 2485                 2490             


Val Trp  Thr Ala Arg Asp Cys  Glu Leu Val His Arg  Asn Gly Ser 
    2495                 2500                 2505             


His Ala  Arg Cys Arg Cys Ser  Arg Thr Gly Thr Phe  Gly Val Leu 
    2510                 2515                 2520             


Met Asp  Ala Ser Pro Arg Glu  Arg Leu Glu Gly Asp  Leu Glu Leu 
    2525                 2530                 2535             


Leu Ala  Val Phe Thr His Val  Val Val Ala Val Ser  Val Ala Ala 
    2540                 2545                 2550             


Leu Val  Leu Thr Ala Ala Ile  Leu Leu Ser Leu Arg  Ser Leu Lys 
    2555                 2560                 2565             


Ser Asn  Val Arg Gly Ile His  Ala Asn Val Ala Ala  Ala Leu Gly 
    2570                 2575                 2580             


Val Ala  Glu Leu Leu Phe Leu  Leu Gly Ile His Arg  Thr His Asn 
    2585                 2590                 2595             


Gln Leu  Val Cys Thr Ala Val  Ala Ile Leu Leu His  Tyr Phe Phe 
    2600                 2605                 2610             


Leu Ser  Thr Phe Ala Trp Leu  Phe Val Gln Gly Leu  His Leu Tyr 
    2615                 2620                 2625             


Arg Met  Gln Val Glu Pro Arg  Asn Val Asp Arg Gly  Ala Met Arg 
    2630                 2635                 2640             


Phe Tyr  His Ala Leu Gly Trp  Gly Val Pro Ala Val  Leu Leu Gly 
    2645                 2650                 2655             


Leu Ala  Val Gly Leu Asp Pro  Glu Gly Tyr Gly Asn  Pro Asp Phe 
    2660                 2665                 2670             


Cys Trp  Ile Ser Val His Glu  Pro Leu Ile Trp Ser  Phe Ala Gly 
    2675                 2680                 2685             


Pro Val  Val Leu Val Ile Val  Met Asn Gly Thr Met  Phe Leu Leu 
    2690                 2695                 2700             


Ala Ala  Arg Thr Ser Cys Ser  Thr Gly Gln Arg Glu  Ala Lys Lys 
    2705                 2710                 2715             


Thr Ser  Ala Leu Thr Leu Arg  Ser Ser Phe Leu Leu  Leu Leu Leu 
    2720                 2725                 2730             


Val Ser  Ala Ser Trp Leu Phe  Gly Leu Leu Ala Val  Asn His Ser 
    2735                 2740                 2745             


Ile Leu  Ala Phe His Tyr Leu  His Ala Gly Leu Cys  Gly Leu Gln 
    2750                 2755                 2760             


Gly Leu  Ala Val Leu Leu Leu  Phe Cys Val Leu Asn  Ala Asp Ala 
    2765                 2770                 2775             


Arg Ala  Ala Trp Met Pro Ala  Cys Leu Gly Arg Lys  Ala Ala Pro 
    2780                 2785                 2790             


Glu Glu  Ala Arg Pro Ala Pro  Gly Leu Gly Pro Gly  Ala Tyr Asn 
    2795                 2800                 2805             


Asn Thr  Ala Leu Phe Glu Glu  Ser Gly Leu Ile Arg  Ile Thr Leu 
    2810                 2815                 2820             


Gly Ala  Ser Thr Val Ser Ser  Val Ser Ser Ala Arg  Ser Gly Arg 
    2825                 2830                 2835             


Thr Gln  Asp Gln Asp Ser Gln  Arg Gly Arg Ser Tyr  Leu Arg Asp 
    2840                 2845                 2850             


Asn Val  Leu Val Arg His Gly  Ser Ala Ala Asp His  Thr Asp His 
    2855                 2860                 2865             


Ser Leu  Gln Ala His Ala Gly  Pro Thr Asp Leu Asp  Val Ala Met 
    2870                 2875                 2880             


Phe His  Arg Asp Ala Gly Ala  Asp Ser Asp Ser Asp  Ser Asp Leu 
    2885                 2890                 2895             


Ser Leu  Glu Glu Glu Arg Ser  Leu Ser Ile Pro Ser  Ser Glu Ser 
    2900                 2905                 2910             


Glu Asp  Asn Gly Arg Thr Arg  Gly Arg Phe Gln Arg  Pro Leu Cys 
    2915                 2920                 2925             


Arg Ala  Ala Gln Ser Glu Arg  Leu Leu Thr His Pro  Lys Asp Val 
    2930                 2935                 2940             


Asp Gly  Asn Asp Leu Leu Ser  Tyr Trp Pro Ala Leu  Gly Glu Cys 
    2945                 2950                 2955             


Glu Ala  Ala Pro Cys Ala Leu  Gln Thr Trp Gly Ser  Glu Arg Arg 
    2960                 2965                 2970             


Leu Gly  Leu Asp Thr Ser Lys  Asp Ala Ala Asn Asn  Asn Gln Pro 
    2975                 2980                 2985             


Asp Pro  Ala Leu Thr Ser Gly  Asp Glu Thr Ser Leu  Gly Arg Ala 
    2990                 2995                 3000             


Gln Arg  Gln Arg Lys Gly Ile  Leu Lys Asn Arg Leu  Gln Tyr Pro 
    3005                 3010                 3015             


Leu Val  Pro Gln Thr Arg Gly  Ala Pro Glu Leu Ser  Trp Cys Arg 
    3020                 3025                 3030             


Ala Ala  Thr Leu Gly His Arg  Ala Val Pro Ala Ala  Ser Tyr Gly 
    3035                 3040                 3045             


Arg Ile  Tyr Ala Gly Gly Gly  Thr Gly Ser Leu Ser  Gln Pro Ala 
    3050                 3055                 3060             


Ser Arg  Tyr Ser Ser Arg Glu  Gln Leu Asp Leu Leu  Leu Arg Arg 
    3065                 3070                 3075             


Gln Leu  Ser Arg Glu Arg Leu  Glu Glu Ala Pro Ala  Pro Val Leu 
    3080                 3085                 3090             


Arg Pro  Leu Ser Arg Pro Gly  Ser Gln Glu Cys Met  Asp Ala Ala 
    3095                 3100                 3105             


Pro Gly  Arg Leu Glu Pro Lys  Asp Arg Gly Ser Thr  Leu Pro Arg 
    3110                 3115                 3120             


Arg Gln  Pro Pro Arg Asp Tyr  Pro Gly Ala Met Ala  Gly Arg Phe 
    3125                 3130                 3135             


Gly Ser  Arg Asp Ala Leu Asp  Leu Gly Ala Pro Arg  Glu Trp Leu 
    3140                 3145                 3150             


Ser Thr  Leu Pro Pro Pro Arg  Arg Thr Arg Asp Leu  Asp Pro Gln 
    3155                 3160                 3165             


Pro Pro  Pro Leu Pro Leu Ser  Pro Gln Arg Gln Leu  Ser Arg Asp 
    3170                 3175                 3180             


Pro Leu  Leu Pro Ser Arg Pro  Leu Asp Ser Leu Ser  Arg Ser Ser 
    3185                 3190                 3195             


Asn Ser  Arg Glu Gln Leu Asp  Gln Val Pro Ser Arg  His Pro Ser 
    3200                 3205                 3210             


Arg Glu  Ala Leu Gly Pro Leu  Pro Gln Leu Leu Arg  Ala Arg Glu 
    3215                 3220                 3225             


Asp Ser  Val Ser Gly Pro Ser  His Gly Pro Ser Thr  Glu Gln Leu 
    3230                 3235                 3240             


Asp Ile  Leu Ser Ser Ile Leu  Ala Ser Phe Asn Ser  Ser Ala Leu 
    3245                 3250                 3255             


Ser Ser  Val Gln Ser Ser Ser  Thr Pro Leu Gly Pro  His Thr Thr 
    3260                 3265                 3270             


Ala Thr  Pro Ser Ala Thr Ala  Ser Val Leu Gly Pro  Ser Thr Pro 
    3275                 3280                 3285             


Arg Ser  Ala Thr Ser His Ser  Ile Ser Glu Leu Ser  Pro Asp Ser 
    3290                 3295                 3300             


Glu Val  Pro Arg Ser Glu Gly  His Ser 
    3305                 3310         


<210>  31
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Arg Pro Arg Ser Ala Leu Pro Arg Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Ala Gly Pro Ala Gln Phe His Gly Glu Lys Gly Ile Ser 
            20                  25                  30          


Ile Pro Asp His Gly Phe Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr 
        35                  40                  45              


Asp Ile Ala Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr 
    50                  55                  60                  


Asn Gln Glu Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val 
65                  70                  75                  80  


Lys Val Gln Cys Ser Pro Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr 
                85                  90                  95      


Ala Pro Val Cys Thr Val Leu Glu Gln Ala Ile Pro Pro Cys Arg Ser 
            100                 105                 110         


Ile Cys Glu Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe 
        115                 120                 125             


Gly Phe Gln Trp Pro Glu Arg Leu Arg Cys Glu His Phe Pro Arg His 
    130                 135                 140                 


Gly Ala Glu Gln Ile Cys Val Gly Gln Asn His Ser Glu Asp Gly Ala 
145                 150                 155                 160 


Pro Ala Leu Leu Thr Thr Ala Pro Pro Pro Gly Leu Gln Pro Gly Ala 
                165                 170                 175     


Gly Gly Thr Pro Gly Gly Pro Gly Gly Gly Gly Ala Pro Pro Arg Tyr 
            180                 185                 190         


Ala Thr Leu Glu His Pro Phe His Cys Pro Arg Val Leu Lys Val Pro 
        195                 200                 205             


Ser Tyr Leu Ser Tyr Lys Phe Leu Gly Glu Arg Asp Cys Ala Ala Pro 
    210                 215                 220                 


Cys Glu Pro Ala Arg Pro Asp Gly Ser Met Phe Phe Ser Gln Glu Glu 
225                 230                 235                 240 


Thr Arg Phe Ala Arg Leu Trp Ile Leu Thr Trp Ser Val Leu Cys Cys 
                245                 250                 255     


Ala Ser Thr Phe Phe Thr Val Thr Thr Tyr Leu Val Asp Met Gln Arg 
            260                 265                 270         


Phe Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr 
        275                 280                 285             


Met Val Ser Val Ala Tyr Ile Ala Gly Phe Val Leu Gln Glu Arg Val 
    290                 295                 300                 


Val Cys Asn Glu Arg Phe Ser Glu Asp Gly Tyr Arg Thr Val Val Gln 
305                 310                 315                 320 


Gly Thr Lys Lys Glu Gly Cys Thr Ile Leu Phe Met Met Leu Tyr Phe 
                325                 330                 335     


Phe Ser Met Ala Ser Ser Ile Trp Trp Val Ile Leu Ser Leu Thr Trp 
            340                 345                 350         


Phe Leu Ala Ala Gly Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn 
        355                 360                 365             


Ser Gln Tyr Phe His Leu Ala Ala Trp Ala Val Pro Ala Val Lys Thr 
    370                 375                 380                 


Ile Thr Ile Leu Ala Met Gly Gln Ile Asp Gly Asp Leu Leu Ser Gly 
385                 390                 395                 400 


Val Cys Phe Val Gly Leu Asn Ser Leu Asp Pro Leu Arg Gly Phe Val 
                405                 410                 415     


Leu Ala Pro Leu Phe Val Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu 
            420                 425                 430         


Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Thr Ile Met Lys His Asp 
        435                 440                 445             


Gly Thr Lys Thr Glu Lys Leu Glu Arg Leu Met Val Arg Ile Gly Val 
    450                 455                 460                 


Phe Ser Val Leu Tyr Thr Val Pro Ala Thr Ile Val Ile Ala Cys Tyr 
465                 470                 475                 480 


Phe Tyr Glu Gln Ala Phe Arg Glu His Trp Glu Arg Ser Trp Val Ser 
                485                 490                 495     


Gln His Cys Lys Ser Leu Ala Ile Pro Cys Pro Ala His Tyr Thr Pro 
            500                 505                 510         


Arg Met Ser Pro Asp Phe Thr Val Tyr Met Ile Lys Tyr Leu Met Thr 
        515                 520                 525             


Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly Lys Thr 
    530                 535                 540                 


Leu His Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser Arg His 
545                 550                 555                 560 


Gly Glu Thr Thr Val 
                565 


<210>  32
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asp Thr Glu Ser Thr Tyr Ser Gly Tyr Ser Tyr Tyr Ser Ser His 
1               5                   10                  15      


Ser Lys Lys Ser His Arg Gln Gly Glu Arg Thr Arg Glu Arg His Lys 
            20                  25                  30          


Ser Pro Arg Asn Lys Asp Gly Arg Gly Ser Glu Lys Ser Val Thr Ile 
        35                  40                  45              


Gln Pro Pro Thr Gly Glu Pro Leu Leu Gly Asn Asp Ser Thr Arg Thr 
    50                  55                  60                  


Glu Glu Val Gln Asp Asp Asn Trp Gly Glu Thr Thr Thr Ala Ile Thr 
65                  70                  75                  80  


Gly Thr Ser Glu His Ser Ile Ser Gln Glu Asp Ile Ala Arg Ile Ser 
                85                  90                  95      


Lys Asp Met Glu Asp Ser Val Gly Leu Asp Cys Lys Arg Tyr Leu Gly 
            100                 105                 110         


Leu Thr Val Ala Ser Phe Leu Gly Leu Leu Val Phe Leu Thr Pro Ile 
        115                 120                 125             


Ala Phe Ile Leu Leu Pro Pro Ile Leu Trp Arg Asp Glu Leu Glu Pro 
    130                 135                 140                 


Cys Gly Thr Ile Cys Glu Gly Leu Phe Ile Ser Met Ala Phe Lys Leu 
145                 150                 155                 160 


Leu Ile Leu Leu Ile Gly Thr Trp Ala Leu Phe Phe Arg Lys Arg Arg 
                165                 170                 175     


Ala Asp Met Pro Arg Val Phe Val Phe Arg Ala Leu Leu Leu Val Leu 
            180                 185                 190         


Ile Phe Leu Phe Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile 
        195                 200                 205             


Leu Asp Ser Arg Asp Arg Asn Tyr Gln Gly Ile Val Gln Tyr Ala Val 
    210                 215                 220                 


Ser Leu Val Asp Ala Leu Leu Phe Ile His Tyr Leu Ala Ile Val Leu 
225                 230                 235                 240 


Leu Glu Leu Arg Gln Leu Gln Pro Met Phe Thr Leu Gln Val Val Arg 
                245                 250                 255     


Ser Thr Asp Gly Glu Ser Arg Phe Tyr Ser Leu Gly His Leu Ser Ile 
            260                 265                 270         


Gln Arg Ala Ala Leu Val Val Leu Glu Asn Tyr Tyr Lys Asp Phe Thr 
        275                 280                 285             


Ile Tyr Asn Pro Asn Leu Leu Thr Ala Ser Lys Phe Arg Ala Ala Lys 
    290                 295                 300                 


His Met Ala Gly Leu Lys Val Tyr Asn Val Asp Gly Pro Ser Asn Asn 
305                 310                 315                 320 


Ala Thr Gly Gln Ser Arg Ala Met Ile Ala Ala Ala Ala Arg Arg Arg 
                325                 330                 335     


Asp Ser Ser His Asn Glu Leu Tyr Tyr Glu Glu Ala Glu His Glu Arg 
            340                 345                 350         


Arg Val Lys Lys Arg Lys Ala Arg Leu Val Val Ala Val Glu Glu Ala 
        355                 360                 365             


Phe Ile His Ile Gln Arg Leu Gln Ala Glu Glu Gln Gln Lys Ala Pro 
    370                 375                 380                 


Gly Glu Val Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Pro Ser 
385                 390                 395                 400 


Met Ala Arg Ala Leu Gln Lys Tyr Leu Arg Ile Thr Arg Gln Gln Asn 
                405                 410                 415     


Tyr His Ser Met Glu Ser Ile Leu Gln His Leu Ala Phe Cys Ile Thr 
            420                 425                 430         


Asn Gly Met Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ser Ala Gly 
        435                 440                 445             


Pro Thr Leu Gln Tyr Asp Lys Asp Arg Trp Leu Ser Thr Gln Trp Arg 
    450                 455                 460                 


Leu Val Ser Asp Glu Ala Val Thr Asn Gly Leu Arg Asp Gly Ile Val 
465                 470                 475                 480 


Phe Val Leu Lys Cys Leu Asp Phe Ser Leu Val Val Asn Val Lys Lys 
                485                 490                 495     


Ile Pro Phe Ile Ile Leu Ser Glu Glu Phe Ile Asp Pro Lys Ser His 
            500                 505                 510         


Lys Phe Val Leu Arg Leu Gln Ser Glu Thr Ser Val 
        515                 520                 


<210>  33
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Asp Thr Glu Ser Gln Tyr Ser Gly Tyr Ser Tyr Lys Ser Gly His 
1               5                   10                  15      


Ser Arg Ser Ser Arg Lys His Arg Asp Arg Arg Asp Arg His Arg Ser 
            20                  25                  30          


Lys Ser Arg Asp Gly Gly Arg Gly Asp Lys Ser Val Thr Ile Gln Ala 
        35                  40                  45              


Pro Gly Glu Pro Leu Leu Asp Asn Glu Ser Thr Arg Gly Asp Glu Arg 
    50                  55                  60                  


Asp Asp Asn Trp Gly Glu Thr Thr Thr Val Val Thr Gly Thr Ser Glu 
65                  70                  75                  80  


His Ser Ile Ser His Asp Asp Leu Thr Arg Ile Ala Lys Asp Met Glu 
                85                  90                  95      


Asp Ser Val Pro Leu Asp Cys Ser Arg His Leu Gly Val Ala Ala Gly 
            100                 105                 110         


Ala Thr Leu Ala Leu Leu Ser Phe Leu Thr Pro Leu Ala Phe Leu Leu 
        115                 120                 125             


Leu Pro Pro Leu Leu Trp Arg Glu Glu Leu Glu Pro Cys Gly Thr Ala 
    130                 135                 140                 


Cys Glu Gly Leu Phe Ile Ser Val Ala Phe Lys Leu Leu Ile Leu Leu 
145                 150                 155                 160 


Leu Gly Ser Trp Ala Leu Phe Phe Arg Arg Pro Lys Ala Ser Leu Pro 
                165                 170                 175     


Arg Val Phe Val Leu Arg Ala Leu Leu Met Val Leu Val Phe Leu Leu 
            180                 185                 190         


Val Val Ser Tyr Trp Leu Phe Tyr Gly Val Arg Ile Leu Asp Ala Arg 
        195                 200                 205             


Glu Arg Ser Tyr Gln Gly Val Val Gln Phe Ala Val Ser Leu Val Asp 
    210                 215                 220                 


Ala Leu Leu Phe Val His Tyr Leu Ala Val Val Leu Leu Glu Leu Arg 
225                 230                 235                 240 


Gln Leu Gln Pro Gln Phe Thr Leu Lys Val Val Arg Ser Thr Asp Gly 
                245                 250                 255     


Ala Ser Arg Phe Tyr Asn Val Gly His Leu Ser Ile Gln Arg Val Ala 
            260                 265                 270         


Val Trp Ile Leu Glu Lys Tyr Tyr His Asp Phe Pro Val Tyr Asn Pro 
        275                 280                 285             


Ala Leu Leu Asn Leu Pro Lys Ser Val Leu Ala Lys Lys Val Ser Gly 
    290                 295                 300                 


Phe Lys Val Tyr Ser Leu Gly Glu Glu Asn Ser Thr Asn Asn Ser Thr 
305                 310                 315                 320 


Gly Gln Ser Arg Ala Val Ile Ala Ala Ala Ala Arg Arg Arg Asp Asn 
                325                 330                 335     


Ser His Asn Glu Tyr Tyr Tyr Glu Glu Ala Glu His Glu Arg Arg Val 
            340                 345                 350         


Arg Lys Arg Arg Ala Arg Leu Val Val Ala Val Glu Glu Ala Phe Thr 
        355                 360                 365             


His Ile Lys Arg Leu Gln Glu Glu Glu Gln Lys Asn Pro Arg Glu Val 
    370                 375                 380                 


Met Asp Pro Arg Glu Ala Ala Gln Ala Ile Phe Ala Ser Met Ala Arg 
385                 390                 395                 400 


Ala Met Gln Lys Tyr Leu Arg Thr Thr Lys Gln Gln Pro Tyr His Thr 
                405                 410                 415     


Met Glu Ser Ile Leu Gln His Leu Glu Phe Cys Ile Thr His Asp Met 
            420                 425                 430         


Thr Pro Lys Ala Phe Leu Glu Arg Tyr Leu Ala Ala Gly Pro Thr Ile 
        435                 440                 445             


Gln Tyr His Lys Glu Arg Trp Leu Ala Lys Gln Trp Thr Leu Val Ser 
    450                 455                 460                 


Glu Glu Pro Val Thr Asn Gly Leu Lys Asp Gly Ile Val Phe Leu Leu 
465                 470                 475                 480 


Lys Arg Gln Asp Phe Ser Leu Val Val Ser Thr Lys Lys Val Pro Phe 
                485                 490                 495     


Phe Lys Leu Ser Glu Glu Phe Val Asp Pro Lys Ser His Lys Phe Val 
            500                 505                 510         


Met Arg Leu Gln Ser Glu Thr Ser Val 
        515                 520     


<210>  34
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Gly Ala Ala Arg Leu Gly Arg Pro Gly Arg Ser Cys Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly Leu Arg Ala Pro Pro Pro Pro Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Leu Leu Pro Leu Leu Pro Ala Pro Gly Ala Ala Ala Ala Pro 
        35                  40                  45              


Ala Pro Arg Pro Pro Glu Leu Gln Ser Ala Ser Ala Gly Pro Ser Val 
    50                  55                  60                  


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Ile Gly Leu Asp 
65                  70                  75                  80  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
                85                  90                  95      


Ser Phe Ser Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
            100                 105                 110         


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
        115                 120                 125             


Asn Val Leu Ala Met Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly 
    130                 135                 140                 


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
145                 150                 155                 160 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
                165                 170                 175     


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
            180                 185                 190         


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
        195                 200                 205             


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
    210                 215                 220                 


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
225                 230                 235                 240 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
                245                 250                 255     


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
            260                 265                 270         


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
        275                 280                 285             


Pro Asn Asn Ala Thr Pro Ile Thr Ser Ser Leu Gly Tyr Pro Thr Leu 
    290                 295                 300                 


Arg Ile Glu Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys 
305                 310                 315                 320 


Gly Lys Val Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys 
                325                 330                 335     


Asp Val Leu Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu 
            340                 345                 350         


Ile Asp Glu Lys Asp Pro Asn Lys Glu Lys Gln Ala Phe Val Lys Thr 
        355                 360                 365             


Val Lys Asp Gln Ala Ser Glu Ile Gln Val Thr Met Met Leu Thr Glu 
    370                 375                 380                 


Ser Cys Lys Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr 
385                 390                 395                 400 


His Val Cys Ile Glu Glu Gly Glu Lys Pro Met Val Ile Leu Pro Tyr 
                405                 410                 415     


Met Asn Trp Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val 
            420                 425                 430         


Glu Ala Asn Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met 
        435                 440                 445             


Ala Ile Gln Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val 
    450                 455                 460                 


Ile His Lys Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu 
465                 470                 475                 480 


Gln Val Lys Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met 
                485                 490                 495     


Asp Tyr His Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met 
            500                 505                 510         


Ala Leu Glu Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val 
        515                 520                 525             


Trp Ala Phe Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr 
    530                 535                 540                 


Pro Tyr Val Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp 
545                 550                 555                 560 


Gly Tyr Arg Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala 
                565                 570                 575     


Val Met Ala Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe 
            580                 585                 590         


Gln Gln Leu Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala 
        595                 600                 605             


Tyr Val 
    610 


<210>  35
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  35

Val Ala Ala Arg Ser Phe Pro Pro Ser Ser Phe Val Met Phe Arg Gly 
1               5                   10                  15      


Leu Arg Gln Arg Phe His Leu Thr Leu Ser Leu Ser Phe Ala Thr Val 
            20                  25                  30          


Gln Gln Ser Gly Leu Leu Phe Tyr Asn Gly Arg Leu Asn Glu Lys His 
        35                  40                  45              


Asp Phe Leu Ala Leu Glu Leu Val Ala Gly Gln Val Arg Leu Thr Tyr 
    50                  55                  60                  


Ser Thr Gly Glu Ser Asn Thr Val Val Ser Pro Thr Val Pro Gly Gly 
65                  70                  75                  80  


Leu Ser Asp Gly Gln Trp His Thr Val His Leu Arg Tyr Tyr Asn Lys 
                85                  90                  95      


Pro Arg Thr Asp Ala Leu Gly Gly Ala Gln Gly Pro Ser Lys Asp Lys 
            100                 105                 110         


Val Ala Val Leu Ser Val Asp Asp Cys Asp Val Ala Val Ala Leu Gln 
        115                 120                 125             


Phe Gly Ala Glu Ile Gly Asn Tyr Ser Cys Ala Ala Ala Gly Val Gln 
    130                 135                 140                 


Thr Ser Ser Lys Lys Ser Leu Asp Leu Thr Gly Pro Leu Leu Leu Gly 
145                 150                 155                 160 


Gly Val Pro Asn Leu Pro Glu Asn Phe Pro Val Ser His Lys Asp Phe 
                165                 170                 175     


Ile Gly Cys Met Arg Asp Leu His Ile Asp Gly Arg Arg Val Asp Met 
            180                 185                 190         


Ala Ala Phe Val Ala Asn Asn Gly Thr Met Ala Gly Cys 
        195                 200                 205 


<210>  36
<211>  204
<212>  PRT
<213>  Mus musculus

<400>  36

Val Ala Ala Arg Ser Phe Pro Pro Ser Ser Phe Val Met Phe Arg Gly 
1               5                   10                  15      


Leu Arg Gln Arg Phe His Leu Thr Leu Ser Leu Ser Phe Ala Thr Val 
            20                  25                  30          


Gln Pro Ser Gly Leu Leu Phe Tyr Asn Gly Arg Leu Asn Glu Lys His 
        35                  40                  45              


Asp Phe Leu Ala Leu Glu Leu Val Ala Gly Gln Val Arg Leu Thr Tyr 
    50                  55                  60                  


Ser Thr Gly Glu Ser Asn Thr Val Val Ser Pro Thr Val Pro Gly Gly 
65                  70                  75                  80  


Leu Ser Asp Gly Gln Trp His Thr Val His Leu Arg Tyr Tyr Asn Lys 
                85                  90                  95      


Pro Arg Thr Asp Ala Leu Gly Gly Ala Gln Gly Pro Ser Lys Asp Lys 
            100                 105                 110         


Val Ala Val Leu Ser Val Asp Asp Cys Asn Val Ala Val Ala Leu Gln 
        115                 120                 125             


Phe Gly Ala Glu Ile Gly Asn Tyr Ser Cys Met Ala Gly Val Gln Thr 
    130                 135                 140                 


Ser Ser Lys Lys Ser Leu Asp Leu Thr Gly Pro Leu Leu Leu Gly Gly 
145                 150                 155                 160 


Val Pro Asn Leu Pro Glu Asn Phe Pro Val Ser His Lys Asp Phe Ile 
                165                 170                 175     


Gly Cys Met Arg Asp Leu His Ile Asp Gly Arg Arg Met Asp Met Ala 
            180                 185                 190         


Ala Phe Val Ala Asn Asn Gly Thr Met Ala Gly Cys 
        195                 200                 


<210>  37
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  37

His Arg Met Asp Gln Gln Cys Pro Arg Gly Trp Trp Gly Ser Pro Thr 
1               5                   10                  15      


Cys Gly Pro Cys Asn Cys Asp Val His Lys Gly Phe Asp Pro Asn Cys 
            20                  25                  30          


Asn 
    


<210>  38
<211>  40
<212>  PRT
<213>  Mus musculus

<400>  38

Tyr Phe Gly Gln His Cys Glu His Arg Val Asp Gln Gln Cys Pro Arg 
1               5                   10                  15      


Gly Trp Trp Gly Ser Pro Thr Cys Gly Pro Cys Asn Cys Asp Val His 
            20                  25                  30          


Lys Gly Phe Asp Pro Asn Cys Asn 
        35                  40  


<210>  39
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  39

Thr Asn Gly Gln Cys His Cys Lys Glu Phe His Tyr Arg Pro Arg Gly 
1               5                   10                  15      


Ser Asp Ser Cys Leu Pro Cys Asp Cys Tyr Pro Val Gly Ser Thr Ser 
            20                  25                  30          


Arg Ser Cys Ala 
        35      


<210>  40
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  41
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  41

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly Lys 
                325         


