                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  T CELL RECEPTORS RECOGNIZING R175H OR Y220C MUTATION IN P53

<130>  749338

<150>  US 62/867,619
<151>  2019-06-27

<160>  230   

<170>  PatentIn version 3.5

<210>  1
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  2
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Val Arg His Cys Pro His His Glu Arg 
1               5                   10      


<210>  3
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Ile Ser Gly Thr Asp Tyr 
1               5           


<210>  4
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Leu Thr Ser Asn 
1               5   


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  5

Cys Ile Leu Arg Asp Asn Asn Ala Arg Leu Met Phe 
1               5                   10          


<210>  6
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn His Glu Tyr 
1               5   


<210>  7
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Met Asn Val Glu Val 
1               5       


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Cys Ala Ser Gly Leu Val Gly Phe Asn Gln Pro Gln His Phe 
1               5                   10                  


<210>  9
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  9

Met His Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Leu Arg Asp Asn Asn Ala 
            100                 105                 110         


Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val Val Lys Pro 
        115                 120                 125     


<210>  10
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Gly Leu Val Gly Phe Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
        115                 120                 125             


Leu Ser Ile Leu 
    130         


<210>  11
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met His Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Leu Arg Asp Asn Asn Ala 
            100                 105                 110         


Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val Val Lys Pro Asn Ile 
        115                 120                 125             


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
    130                 135                 140                 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
145                 150                 155                 160 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
                165                 170                 175     


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
            180                 185                 190         


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
        195                 200                 205             


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
    210                 215                 220                 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
225                 230                 235                 240 


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
                245                 250                 255     


Thr Leu Arg Leu Trp Ser Ser 
            260             


<210>  12
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Gly Leu Val Gly Phe Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
        115                 120                 125             


Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  13
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Gly Leu Val Gly Phe Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
        115                 120                 125             


Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
305                 310                 315                 320 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Val 
                325                 330                 335     


Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met Gly Asp Ala Lys 
            340                 345                 350         


Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu Glu Pro Val His 
        355                 360                 365             


Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp Tyr Ile His Trp 
    370                 375                 380                 


Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val Ile His Gly Leu 
385                 390                 395                 400 


Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala Ile Ala Glu Asp 
                405                 410                 415     


Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr Leu Arg Asp Ala 
            420                 425                 430         


Ala Val Tyr Tyr Cys Ile Leu Arg Asp Asn Asn Ala Arg Leu Met Phe 
        435                 440                 445             


Gly Asp Gly Thr Gln Leu Val Val Lys Pro Asn Ile Gln Asn Pro Glu 
    450                 455                 460                 


Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu 
465                 470                 475                 480 


Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met 
                485                 490                 495     


Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala 
            500                 505                 510         


Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser 
        515                 520                 525             


Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser 
    530                 535                 540                 


Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr 
545                 550                 555                 560 


Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile 
                565                 570                 575     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            580                 585                 590         


Trp Ser Ser 
        595 


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  14

Thr Ile Ser Gly Asn Glu Tyr 
1               5           


<210>  15
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Leu Lys Asn Asn 
1               5   


<210>  16
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly Thr Ser Tyr Gly Lys 
1               5                   10                  15      


Leu Thr Phe 
            


<210>  17
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  17

Leu Asn His Asp Ala 
1               5   


<210>  18
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Gln Ile Val Asn Asp 
1               5       


<210>  19
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  19

Cys Ala Ser Leu Gln Phe Asn Glu Gln Phe Phe 
1               5                   10      


<210>  20
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  20

Met His Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro 
    130             


<210>  21
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu 
1               5                   10                  15      


Gly Ala Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu 
            20                  25                  30          


Phe Arg Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu 
        35                  40                  45              


Asn His Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu 
    50                  55                  60                  


Arg Leu Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp 
65                  70                  75                  80  


Ile Ala Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro 
                85                  90                  95      


Leu Thr Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys 
            100                 105                 110         


Ala Ser Leu Gln Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu 
    130     


<210>  22
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Met His Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  23
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Ala Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu 
1               5                   10                  15      


Gly Ala Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu 
            20                  25                  30          


Phe Arg Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu 
        35                  40                  45              


Asn His Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu 
    50                  55                  60                  


Arg Leu Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp 
65                  70                  75                  80  


Ile Ala Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro 
                85                  90                  95      


Leu Thr Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys 
            100                 105                 110         


Ala Ser Leu Gln Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  24
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Ala Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu 
1               5                   10                  15      


Gly Ala Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu 
            20                  25                  30          


Phe Arg Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu 
        35                  40                  45              


Asn His Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu 
    50                  55                  60                  


Arg Leu Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp 
65                  70                  75                  80  


Ile Ala Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro 
                85                  90                  95      


Leu Thr Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys 
            100                 105                 110         


Ala Ser Leu Gln Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
305                 310                 315                 320 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Val Ala 
                325                 330                 335     


Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile Ile Asp Ala Lys Thr 
            340                 345                 350         


Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala Asn Leu 
        355                 360                 365             


Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr Trp Tyr 
    370                 375                 380                 


Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys 
385                 390                 395                 400 


Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu Asp Arg 
                405                 410                 415     


Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp Thr Ala 
            420                 425                 430         


Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly Thr Ser 
        435                 440                 445             


Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro 
    450                 455                 460                 


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
465                 470                 475                 480 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
                485                 490                 495     


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
            500                 505                 510         


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
        515                 520                 525             


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
    530                 535                 540                 


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
545                 550                 555                 560 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
                565                 570                 575     


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
            580                 585                 590         


Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600     


<210>  25
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  25

Val Ser Asn Ala Tyr Asn 
1               5       


<210>  26
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Ser Lys Pro 
1               


<210>  27
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  27

Cys Ala Val Glu Asp Arg Arg Arg Thr Ala Leu Ile Phe 
1               5                   10              


<210>  28
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  28

Ser Asn His Leu Tyr 
1               5   


<210>  29
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  29

Phe Tyr Asn Asn Glu Ile 
1               5       


<210>  30
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  30

Cys Ala Ser Ser Glu Tyr Gln Ser Gln Ser Asn Glu Gln Phe Phe 
1               5                   10                  15  


<210>  31
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  31

Met His Leu Gln Ser Thr Leu Gly Ala Val Trp Leu Gly Leu Leu Leu 
1               5                   10                  15      


Asn Ser Leu Trp Lys Val Ala Glu Ser Lys Asp Gln Val Phe Gln Pro 
            20                  25                  30          


Ser Thr Val Ala Ser Ser Glu Gly Ala Val Val Glu Ile Phe Cys Asn 
        35                  40                  45              


His Ser Val Ser Asn Ala Tyr Asn Phe Phe Trp Tyr Leu His Phe Pro 
    50                  55                  60                  


Gly Cys Ala Pro Arg Leu Leu Val Lys Gly Ser Lys Pro Ser Gln Gln 
65                  70                  75                  80  


Gly Arg Tyr Asn Met Thr Tyr Glu Arg Phe Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Leu Gln Val Arg Glu Ala Asp Ala Ala Val Tyr Tyr Cys Ala Val Glu 
            100                 105                 110         


Asp Arg Arg Arg Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu Ser 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  32
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Glu Tyr Gln Ser Gln Ser Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  33
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Met His Leu Gln Ser Thr Leu Gly Ala Val Trp Leu Gly Leu Leu Leu 
1               5                   10                  15      


Asn Ser Leu Trp Lys Val Ala Glu Ser Lys Asp Gln Val Phe Gln Pro 
            20                  25                  30          


Ser Thr Val Ala Ser Ser Glu Gly Ala Val Val Glu Ile Phe Cys Asn 
        35                  40                  45              


His Ser Val Ser Asn Ala Tyr Asn Phe Phe Trp Tyr Leu His Phe Pro 
    50                  55                  60                  


Gly Cys Ala Pro Arg Leu Leu Val Lys Gly Ser Lys Pro Ser Gln Gln 
65                  70                  75                  80  


Gly Arg Tyr Asn Met Thr Tyr Glu Arg Phe Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Leu Gln Val Arg Glu Ala Asp Ala Ala Val Tyr Tyr Cys Ala Val Glu 
            100                 105                 110         


Asp Arg Arg Arg Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu Ser 
        115                 120                 125             


Val Ser Ser Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  34
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Met Ala Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Glu Tyr Gln Ser Gln Ser Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  35
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Met Ala Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Glu Tyr Gln Ser Gln Ser Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His 
                325                 330                 335     


Leu Gln Ser Thr Leu Gly Ala Val Trp Leu Gly Leu Leu Leu Asn Ser 
            340                 345                 350         


Leu Trp Lys Val Ala Glu Ser Lys Asp Gln Val Phe Gln Pro Ser Thr 
        355                 360                 365             


Val Ala Ser Ser Glu Gly Ala Val Val Glu Ile Phe Cys Asn His Ser 
    370                 375                 380                 


Val Ser Asn Ala Tyr Asn Phe Phe Trp Tyr Leu His Phe Pro Gly Cys 
385                 390                 395                 400 


Ala Pro Arg Leu Leu Val Lys Gly Ser Lys Pro Ser Gln Gln Gly Arg 
                405                 410                 415     


Tyr Asn Met Thr Tyr Glu Arg Phe Ser Ser Ser Leu Leu Ile Leu Gln 
            420                 425                 430         


Val Arg Glu Ala Asp Ala Ala Val Tyr Tyr Cys Ala Val Glu Asp Arg 
        435                 440                 445             


Arg Arg Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu Ser Val Ser 
    450                 455                 460                 


Ser Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
465                 470                 475                 480 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                485                 490                 495     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            500                 505                 510         


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        515                 520                 525             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    530                 535                 540                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
545                 550                 555                 560 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                565                 570                 575     


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            580                 585                 590         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600         


<210>  36
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  36

Thr Ile Ser Gly Asn Glu Tyr 
1               5           


<210>  37
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  37

Gly Leu Lys Asn Asn 
1               5   


<210>  38
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  38

Cys Ile Val Arg Gly Ser Pro Gly Ala Gly Gly Thr Ser Tyr Gly Lys 
1               5                   10                  15      


Leu Thr Phe 
            


<210>  39
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  39

Leu Asn His Asp Ala 
1               5   


<210>  40
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  40

Ser Gln Ile Val Asn Asp 
1               5       


<210>  41
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  41

Cys Ala Ser Ser Ile Arg Thr Glu Ala Phe Phe 
1               5                   10      


<210>  42
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  42

Met His Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Gly Ser Pro Gly 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro 
    130             


<210>  43
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ile Arg Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val 
    


<210>  44
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Met His Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Gly Ser Pro Gly 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  45
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ile Arg Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  46
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ile Arg Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala 
    290                 295                 300                 


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
305                 310                 315                 320 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Val Ala Arg Val 
                325                 330                 335     


Thr Val Phe Leu Thr Phe Gly Thr Ile Ile Asp Ala Lys Thr Thr Gln 
            340                 345                 350         


Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala Asn Leu Pro Cys 
        355                 360                 365             


Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr Trp Tyr Arg Gln 
    370                 375                 380                 


Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys Asn Asn 
385                 390                 395                 400 


Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu Asp Arg Lys Ser 
                405                 410                 415     


Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp Thr Ala Val Tyr 
            420                 425                 430         


Tyr Cys Ile Val Arg Gly Ser Pro Gly Ala Gly Gly Thr Ser Tyr Gly 
        435                 440                 445             


Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile 
    450                 455                 460                 


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
465                 470                 475                 480 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
                485                 490                 495     


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
            500                 505                 510         


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
        515                 520                 525             


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
    530                 535                 540                 


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
545                 550                 555                 560 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
                565                 570                 575     


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
            580                 585                 590         


Thr Leu Arg Leu Trp Ser Ser 
        595                 


<210>  47
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  47

Thr Thr Leu Ser Asn 
1               5   


<210>  48
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  48

Leu Val Lys Ser Gly Glu Val 
1               5           


<210>  49
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  49

Cys Ala Gly Pro Gly Gly Ala Gly Ser Tyr Gln Leu Thr Phe 
1               5                   10                  


<210>  50
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asn His Glu Tyr 
1               5   


<210>  51
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  51

Ser Met Asn Val Glu Val 
1               5       


<210>  52
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  52

Cys Ala Ser Ser Pro Phe Val Val Ile Gly Gln Ile Asn Glu Gln Tyr 
1               5                   10                  15      


Phe 
    


<210>  53
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  53

Met His Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      


Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          


Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              


Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  


Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Pro Gly Gly 
            100                 105                 110         


Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val 
        115                 120                 125             


Ile Pro 
    130 


<210>  54
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Phe Val Val Ile Gly Gln Ile Asn Glu Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Thr 
    130                 135 


<210>  55
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Met His Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      


Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          


Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              


Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  


Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Pro Gly Gly 
            100                 105                 110         


Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val 
        115                 120                 125             


Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  56
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Phe Val Val Ile Gly Gln Ile Asn Glu Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser 
305             


<210>  57
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Phe Val Val Ile Gly Gln Ile Asn Glu Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


His Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln Val 
            340                 345                 350         


Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln Glu 
        355                 360                 365             


Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser Asn 
    370                 375                 380                 


Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu Ile 
385                 390                 395                 400 


Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr Phe 
                405                 410                 415     


Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala Thr 
            420                 425                 430         


Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Pro Gly Gly Ala 
        435                 440                 445             


Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val Ile 
    450                 455                 460                 


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
465                 470                 475                 480 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                485                 490                 495     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            500                 505                 510         


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        515                 520                 525             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    530                 535                 540                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
545                 550                 555                 560 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                565                 570                 575     


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            580                 585                 590         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600         


<210>  58
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  58

Thr Thr Ser Asp Arg 
1               5   


<210>  59
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  59

Leu Leu Ser Asn Gly Ala Val 
1               5           


<210>  60
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  60

Cys Ala Val Ala His Met Asp Ser Asn Tyr Gln Leu Ile Trp 
1               5                   10                  


<210>  61
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Asn His Glu Tyr 
1               5   


<210>  62
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  62

Ser Val Gly Glu Gly Thr 
1               5       


<210>  63
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  63

Cys Ala Ser Ser Tyr Ala Gly Leu Ala Ala Pro Arg Glu Gln Phe Phe 
1               5                   10                  15      


<210>  64
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  64

Met His Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu 
1               5                   10                  15      


Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln 
            20                  25                  30          


Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp 
        35                  40                  45              


Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu 
    50                  55                  60                  


Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met 
65                  70                  75                  80  


Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala 
                85                  90                  95      


Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Ala His Met 
            100                 105                 110         


Asp Ser Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile 
        115                 120                 125             


Lys Pro 
    130 


<210>  65
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Ala Gly Leu Ala Ala Pro Arg Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  66
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Met His Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu 
1               5                   10                  15      


Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln 
            20                  25                  30          


Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp 
        35                  40                  45              


Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu 
    50                  55                  60                  


Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met 
65                  70                  75                  80  


Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala 
                85                  90                  95      


Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Ala His Met 
            100                 105                 110         


Asp Ser Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile 
        115                 120                 125             


Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  67
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Met Ala Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Ala Gly Leu Ala Ala Pro Arg Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  68
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Met Ala Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Ala Gly Leu Ala Ala Pro Arg Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His 
                325                 330                 335     


Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu Ser Gly 
            340                 345                 350         


Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln Glu Gly 
        355                 360                 365             


Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp Arg Leu 
    370                 375                 380                 


Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu Phe Val 
385                 390                 395                 400 


Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met Ala Ser 
                405                 410                 415     


Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala Ala Val 
            420                 425                 430         


His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Ala His Met Asp Ser 
        435                 440                 445             


Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro 
    450                 455                 460                 


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
465                 470                 475                 480 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
                485                 490                 495     


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
            500                 505                 510         


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
        515                 520                 525             


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
    530                 535                 540                 


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
545                 550                 555                 560 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
                565                 570                 575     


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
            580                 585                 590         


Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600     


<210>  69
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  69

Thr Ile Ser Gly Asn Glu Tyr 
1               5           


<210>  70
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  70

Gly Leu Lys Asn Asn 
1               5   


<210>  71
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  71

Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly Thr Ser Tyr Gly Lys 
1               5                   10                  15      


Leu Thr Phe 
            


<210>  72
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  72

Leu Asn His Asp Ala 
1               5   


<210>  73
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  73

Ser Gln Ile Val Asn Asp 
1               5       


<210>  74
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  74

Cys Ala Thr Arg Thr Gly Asn Glu Ala Phe Phe 
1               5                   10      


<210>  75
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  75

Met His Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro 
    130             


<210>  76
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Thr 
            100                 105                 110         


Arg Thr Gly Asn Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val 
    


<210>  77
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Met His Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  78
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Thr 
            100                 105                 110         


Arg Thr Gly Asn Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  79
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Thr 
            100                 105                 110         


Arg Thr Gly Asn Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala 
    290                 295                 300                 


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
305                 310                 315                 320 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Val Ala Arg Val 
                325                 330                 335     


Thr Val Phe Leu Thr Phe Gly Thr Ile Ile Asp Ala Lys Thr Thr Gln 
            340                 345                 350         


Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala Asn Leu Pro Cys 
        355                 360                 365             


Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr Trp Tyr Arg Gln 
    370                 375                 380                 


Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys Asn Asn 
385                 390                 395                 400 


Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu Asp Arg Lys Ser 
                405                 410                 415     


Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp Thr Ala Val Tyr 
            420                 425                 430         


Tyr Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly Thr Ser Tyr Gly 
        435                 440                 445             


Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile 
    450                 455                 460                 


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
465                 470                 475                 480 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
                485                 490                 495     


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
            500                 505                 510         


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
        515                 520                 525             


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
    530                 535                 540                 


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
545                 550                 555                 560 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
                565                 570                 575     


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
            580                 585                 590         


Thr Leu Arg Leu Trp Ser Ser 
        595                 


<210>  80
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  80

Val Ser Gly Asn Pro Tyr 
1               5       


<210>  81
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  81

Tyr Ile Thr Gly Asp Asn Leu Val 
1               5               


<210>  82
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  82

Cys Ala Val Arg Asp Gly Ser Ala Thr Ser Gly Thr Tyr Lys Tyr Ile 
1               5                   10                  15      


Phe 
    


<210>  83
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  83

Ser Glu His Asn Arg 
1               5   


<210>  84
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  84

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  85
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  85

Cys Ala Ser Ser Pro Gly Leu Ala Tyr Glu Gln Tyr Phe 
1               5                   10              


<210>  86
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  86

Met His Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Gly Ser Ala Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr 
        115                 120                 125             


Gly Thr Arg Leu Lys Val Leu Ala 
    130                 135     


<210>  87
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Leu Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr 
    130         


<210>  88
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88

Met His Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Gly Ser Ala Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr 
        115                 120                 125             


Gly Thr Arg Leu Lys Val Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  89
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89

Met Ala Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Leu Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  90
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90

Met Ala Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Leu Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
305                 310                 315                 320 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Ser Ala 
                325                 330                 335     


Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser Gly Leu Arg Ala 
            340                 345                 350         


Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly Asn 
        355                 360                 365             


Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr Leu 
    370                 375                 380                 


Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu Lys 
385                 390                 395                 400 


Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu Ala 
                405                 410                 415     


Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser Ala 
            420                 425                 430         


Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Gly Ser 
        435                 440                 445             


Ala Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu 
    450                 455                 460                 


Lys Val Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
465                 470                 475                 480 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
                485                 490                 495     


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
            500                 505                 510         


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
        515                 520                 525             


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
    530                 535                 540                 


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
545                 550                 555                 560 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
                565                 570                 575     


Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala 
            580                 585                 590         


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605 


<210>  91
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  92
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  93
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  94
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  95
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  95

His Met Thr Glu Val Val Arg Arg Cys 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  96

His Met Thr Glu Val Val Arg His Cys 
1               5                   


<210>  97
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  97

Ser Ser Cys Met Gly Gly Met Asn Arg Arg 
1               5                   10  


<210>  98
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  98

Ser Ser Cys Met Gly Gly Met Asn Trp Arg 
1               5                   10  


<210>  99
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  99

Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg His Cys Pro 
1               5                   10                  15  


<210>  100
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  100

Lys Gln Ser Gln His Met Thr Glu Val Val Arg His Cys Pro His 
1               5                   10                  15  


<210>  101
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  101

Gln Ser Gln His Met Thr Glu Val Val Arg His Cys Pro His His 
1               5                   10                  15  


<210>  102
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  102

Ser Gln His Met Thr Glu Val Val Arg His Cys Pro His His Glu 
1               5                   10                  15  


<210>  103
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  103

Gln His Met Thr Glu Val Val Arg His Cys Pro His His Glu Arg 
1               5                   10                  15  


<210>  104
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  104

His Met Thr Glu Val Val Arg His Cys Pro His His Glu Arg Cys 
1               5                   10                  15  


<210>  105
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Thr Glu Val Val Arg His Cys Pro His His Glu Arg Cys Ser 
1               5                   10                  15  


<210>  106
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  106

Thr Glu Val Val Arg His Cys Pro His His Glu Arg Cys Ser Asp 
1               5                   10                  15  


<210>  107
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  107

Glu Val Val Arg His Cys Pro His His Glu Arg Cys Ser Asp Ser 
1               5                   10                  15  


<210>  108
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  108

Val Val Arg His Cys Pro His His Glu Arg Cys Ser Asp Ser Asp 
1               5                   10                  15  


<210>  109
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  109

Val Arg His Cys Pro His His Glu Arg Cys Ser Asp Ser Asp Gly 
1               5                   10                  15  


<210>  110
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  110

Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His 
1               5                   10                  15      


His Glu Arg Cys Ser Asp Ser Asp Gly 
            20                  25  


<210>  111
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  111

Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg His Cys Pro His 
1               5                   10                  15      


His Glu Arg Cys Ser Asp Ser Asp Gly 
            20                  25  


<210>  112
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  112

Val Val Pro Tyr Glu Pro Pro Glu Val 
1               5                   


<210>  113
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  113

Val Val Pro Cys Glu Pro Pro Glu Val 
1               5                   


<210>  114
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe 
                325                 330                 335     


Gln Lys Glu Asn Cys 
            340     


<210>  115
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu 
                325                 330                 335     


Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 
            340                 345     


<210>  116
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu 
    290                 295                 300                 


Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro 
305                 310                 315                 320 


Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys Lys Gly Gln 
                325                 330                 335     


Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu Gly Pro Asp 
            340                 345                 350         


Ser Asp 
        


<210>  117
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn Cys 
    290                 295                 300         


<210>  118
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr Phe Leu Ile 
    290                 295                 300                 


Asn Ser Ser 
305         


<210>  119
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met 
        195                 200                 205             


Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly 
    210                 215                 220                 


Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys 
225                 230                 235                 240 


Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu 
                245                 250                 255     


Gly Pro Asp Ser Asp 
            260     


<210>  120
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn 
        195                 200                 205             


Cys 
    


<210>  121
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr 
        195                 200                 205             


Phe Leu Ile Asn Ser Ser 
    210                 


<210>  122
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  122

Cys Ala Ser Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe 
1               5                   10                  


<210>  123
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  123

Cys Ala Ser Ser Ile Asn Arg Tyr Thr Glu Ala Phe Phe 
1               5                   10              


<210>  124
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  124

Cys Ala Ser Ser Tyr Pro Ser Met Asp Arg Asp Arg Tyr Gly Tyr Thr 
1               5                   10                  15      


Phe 
    


<210>  125
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  125

Cys Ala Ser Asn Leu Gly Gly Gly Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  126
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  126

Cys Ala Ser Ser Phe Gly Ser Gly Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  127
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  127

Cys Ala Ser Ser Ser Arg Asp Tyr Glu Gln Tyr Phe 
1               5                   10          


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128

Arg Ala Lys Arg Ser Gly Ser Gly 
1               5               


<210>  129
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu 
        115 


<210>  130
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu 
        115 


<210>  131
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  131

Asn Ser Ala Phe Gln Tyr 
1               5       


<210>  132
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  132

Thr Tyr Ser Ser Gly Asn 
1               5       


<210>  133
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  133

Cys Ala Met Ser Gly Leu Lys Glu Asp Ser Ser Tyr Lys Leu Ile Phe 
1               5                   10                  15      


<210>  134
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Asn His Glu Tyr 
1               5   


<210>  135
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  135

Ser Met Asn Val Glu Val 
1               5       


<210>  136
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  136

Cys Ala Ser Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe 
1               5                   10                  


<210>  137
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Ser Gly Leu Lys Glu Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Arg Pro 
    130                 135     


<210>  138
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  138

Met His Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu 
    130         


<210>  139
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  139

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Ser Gly Leu Lys Glu Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Arg Pro Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  140
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  140

Met His Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  141
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  141

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Ser Gly Leu Lys Glu Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Arg Pro Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Pro Gln 
    290                 295                 300                 


Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala Gly Pro Leu Glu 
305                 310                 315                 320 


Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys 
                325                 330                 335     


Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser 
            340                 345                 350         


Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser 
        355                 360                 365             


Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys 
    370                 375                 380                 


Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro 
385                 390                 395                 400 


Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Ile Gln Gln 
                405                 410                 415     


Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            420                 425                 430         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        435                 440                 445             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    450                 455                 460                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
465                 470                 475                 480 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                485                 490                 495     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    530                 535                 540                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605 


<210>  142
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  142

Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu Glu Pro Val 
1               5                   10                  15      


His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp Tyr Ile His 
            20                  25                  30          


Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val Ile His Gly 
        35                  40                  45              


Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala Ile Ala Glu 
    50                  55                  60                  


Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr Leu Arg Asp 
65                  70                  75                  80  


Ala Ala Val Tyr Tyr Cys Ile Leu Arg Asp Asn Asn Ala Arg Leu Met 
                85                  90                  95      


Phe Gly Asp Gly Thr Gln Leu Val Val Lys Pro 
            100                 105         


<210>  143
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  143

Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys 
1               5                   10                  15      


Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met 
        35                  40                  45              


Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val 
    50                  55                  60                  


Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Ser 
65                  70                  75                  80  


Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Gly Leu Val Gly Phe 
                85                  90                  95      


Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
            100                 105                 110     


<210>  144
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  144

Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala 
1               5                   10                  15      


Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr 
            20                  25                  30          


Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly 
        35                  40                  45              


Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu 
    50                  55                  60                  


Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp 
65                  70                  75                  80  


Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly 
                85                  90                  95      


Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val 
            100                 105                 110         


His Pro 
        


<210>  145
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  145

Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn 
1               5                   10                  15      


Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln 
        35                  40                  45              


Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val 
    50                  55                  60                  


Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln 
65                  70                  75                  80  


Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser Leu Gln Phe Asn Glu 
                85                  90                  95      


Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105             


<210>  146
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  146

Lys Asp Gln Val Phe Gln Pro Ser Thr Val Ala Ser Ser Glu Gly Ala 
1               5                   10                  15      


Val Val Glu Ile Phe Cys Asn His Ser Val Ser Asn Ala Tyr Asn Phe 
            20                  25                  30          


Phe Trp Tyr Leu His Phe Pro Gly Cys Ala Pro Arg Leu Leu Val Lys 
        35                  40                  45              


Gly Ser Lys Pro Ser Gln Gln Gly Arg Tyr Asn Met Thr Tyr Glu Arg 
    50                  55                  60                  


Phe Ser Ser Ser Leu Leu Ile Leu Gln Val Arg Glu Ala Asp Ala Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Val Glu Asp Arg Arg Arg Thr Ala Leu Ile Phe 
                85                  90                  95      


Gly Lys Gly Thr Thr Leu Ser Val Ser Ser 
            100                 105     


<210>  147
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  147

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Glu 
                85                  90                  95      


Tyr Gln Ser Gln Ser Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  148
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  148

Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala 
1               5                   10                  15      


Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr 
            20                  25                  30          


Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly 
        35                  40                  45              


Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu 
    50                  55                  60                  


Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp 
65                  70                  75                  80  


Thr Ala Val Tyr Tyr Cys Ile Val Arg Gly Ser Pro Gly Ala Gly Gly 
                85                  90                  95      


Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val 
            100                 105                 110         


His Pro 
        


<210>  149
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  149

Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn 
1               5                   10                  15      


Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln 
        35                  40                  45              


Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val 
    50                  55                  60                  


Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln 
65                  70                  75                  80  


Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser Ser Ile Arg Thr Glu 
                85                  90                  95      


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val 
            100                 105             


<210>  150
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  150

Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln Glu Gly Glu 
1               5                   10                  15      


Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser Asn Ile Gln 
            20                  25                  30          


Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu Ile Gln Leu 
        35                  40                  45              


Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr Phe Gln Phe 
    50                  55                  60                  


Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala Thr Gln Thr 
65                  70                  75                  80  


Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Pro Gly Gly Ala Gly Ser 
                85                  90                  95      


Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val Ile Pro 
            100                 105                 110     


<210>  151
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  151

Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys 
1               5                   10                  15      


Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met 
        35                  40                  45              


Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val 
    50                  55                  60                  


Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Ser 
65                  70                  75                  80  


Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Pro Phe Val Val 
                85                  90                  95      


Ile Gly Gln Ile Asn Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Thr 
        


<210>  152
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  152

Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln Glu Gly 
1               5                   10                  15      


Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu Phe Val 
        35                  40                  45              


Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met Ala Ser 
    50                  55                  60                  


Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala Ala Val 
65                  70                  75                  80  


His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Ala His Met Asp Ser 
                85                  90                  95      


Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro 
            100                 105                 110         


<210>  153
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  153

Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu Lys Thr Gly Gln Ser 
1               5                   10                  15      


Met Thr Leu Leu Cys Ala Gln Asp Met Asn His Glu Tyr Met Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr Ser Val 
        35                  40                  45              


Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro Asp Gly Tyr Asn Val 
    50                  55                  60                  


Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly Leu Glu Ser Ala Ala 
65                  70                  75                  80  


Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ala Gly Leu 
                85                  90                  95      


Ala Ala Pro Arg Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu 
    


<210>  154
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  154

Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala 
1               5                   10                  15      


Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr 
            20                  25                  30          


Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly 
        35                  40                  45              


Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu 
    50                  55                  60                  


Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp 
65                  70                  75                  80  


Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly 
                85                  90                  95      


Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val 
            100                 105                 110         


His Pro 
        


<210>  155
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  155

Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn 
1               5                   10                  15      


Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln 
        35                  40                  45              


Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val 
    50                  55                  60                  


Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln 
65                  70                  75                  80  


Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Thr Arg Thr Gly Asn Glu 
                85                  90                  95      


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val 
            100                 105             


<210>  156
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  156

Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly Asn 
1               5                   10                  15      


Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr Leu 
            20                  25                  30          


Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu Lys 
        35                  40                  45              


Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu Ala 
    50                  55                  60                  


Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser Ala 
65                  70                  75                  80  


Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Gly Ser 
                85                  90                  95      


Ala Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu 
            100                 105                 110         


Lys Val Leu Ala 
        115     


<210>  157
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  157

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Leu Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Thr 
    


<210>  158
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  158

Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys 
1               5                   10                  15      


Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met 
        35                  40                  45              


Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val 
    50                  55                  60                  


Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Ser 
65                  70                  75                  80  


Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Ile Gln Gln Gly 
                85                  90                  95      


Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110     


<210>  159
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  159

Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu Ser Val Pro Glu 
1               5                   10                  15      


Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn Ser Ala Phe Gln 
            20                  25                  30          


Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly Pro Glu Leu Leu 
        35                  40                  45              


Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly Arg Phe Thr Ala 
    50                  55                  60                  


Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe Ile Arg Asp Ser 
65                  70                  75                  80  


Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Met Ser Gly Leu Lys 
                85                  90                  95      


Glu Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser Gly Thr Arg Leu Leu 
            100                 105                 110         


Val Arg Pro 
        115 


<210>  160
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  160

Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu Glu Pro Val 
1               5                   10                  15      


His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp Tyr Ile His 
            20                  25                  30          


Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val Ile His Gly 
        35                  40                  45              


Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala Ile Ala Glu 
    50                  55                  60                  


Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr Leu Arg Asp 
65                  70                  75                  80  


Ala Ala Val Tyr Tyr Cys Ile Leu Arg Asp Asn Asn Ala Arg Leu Met 
                85                  90                  95      


Phe Gly Asp Gly Thr Gln Leu Val Val Lys Pro Asn Ile Gln Asn Pro 
            100                 105                 110         


Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr 
        115                 120                 125             


Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr 
    130                 135                 140                 


Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys 
145                 150                 155                 160 


Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr 
                165                 170                 175     


Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro 
            180                 185                 190         


Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu 
        195                 200                 205             


Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg 
    210                 215                 220                 


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
225                 230                 235                 240 


Leu Trp Ser Ser 
                


<210>  161
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  161

Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys 
1               5                   10                  15      


Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met 
        35                  40                  45              


Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val 
    50                  55                  60                  


Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Ser 
65                  70                  75                  80  


Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Gly Leu Val Gly Phe 
                85                  90                  95      


Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu 
            100                 105                 110         


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
        115                 120                 125             


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
    130                 135                 140                 


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
145                 150                 155                 160 


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
                165                 170                 175     


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
            180                 185                 190         


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
        195                 200                 205             


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
    210                 215                 220                 


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
225                 230                 235                 240 


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
                245                 250                 255     


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
            260                 265                 270         


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 


<210>  162
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  162

Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala 
1               5                   10                  15      


Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr 
            20                  25                  30          


Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly 
        35                  40                  45              


Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu 
    50                  55                  60                  


Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp 
65                  70                  75                  80  


Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly 
                85                  90                  95      


Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val 
            100                 105                 110         


His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
        115                 120                 125             


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
    130                 135                 140                 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
145                 150                 155                 160 


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
                165                 170                 175     


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
            180                 185                 190         


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
        195                 200                 205             


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
    210                 215                 220                 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
225                 230                 235                 240 


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250     


<210>  163
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  163

Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn 
1               5                   10                  15      


Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln 
        35                  40                  45              


Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val 
    50                  55                  60                  


Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln 
65                  70                  75                  80  


Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser Leu Gln Phe Asn Glu 
                85                  90                  95      


Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg 
            100                 105                 110         


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
        115                 120                 125             


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
    130                 135                 140                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
145                 150                 155                 160 


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
                165                 170                 175     


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
            180                 185                 190         


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
        195                 200                 205             


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
    210                 215                 220                 


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
225                 230                 235                 240 


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
                245                 250                 255     


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
            260                 265                 270         


Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280     


<210>  164
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  164

Lys Asp Gln Val Phe Gln Pro Ser Thr Val Ala Ser Ser Glu Gly Ala 
1               5                   10                  15      


Val Val Glu Ile Phe Cys Asn His Ser Val Ser Asn Ala Tyr Asn Phe 
            20                  25                  30          


Phe Trp Tyr Leu His Phe Pro Gly Cys Ala Pro Arg Leu Leu Val Lys 
        35                  40                  45              


Gly Ser Lys Pro Ser Gln Gln Gly Arg Tyr Asn Met Thr Tyr Glu Arg 
    50                  55                  60                  


Phe Ser Ser Ser Leu Leu Ile Leu Gln Val Arg Glu Ala Asp Ala Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Ala Val Glu Asp Arg Arg Arg Thr Ala Leu Ile Phe 
                85                  90                  95      


Gly Lys Gly Thr Thr Leu Ser Val Ser Ser Asn Ile Gln Asn Pro Glu 
            100                 105                 110         


Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu 
        115                 120                 125             


Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met 
    130                 135                 140                 


Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala 
145                 150                 155                 160 


Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser 
                165                 170                 175     


Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser 
            180                 185                 190         


Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr 
        195                 200                 205             


Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile 
    210                 215                 220                 


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
225                 230                 235                 240 


Trp Ser Ser 
            


<210>  165
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  165

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Glu 
                85                  90                  95      


Tyr Gln Ser Gln Ser Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        115                 120                 125             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
                165                 170                 175     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            180                 185                 190         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        195                 200                 205             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    210                 215                 220                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
225                 230                 235                 240 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                245                 250                 255     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            260                 265                 270         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285             


<210>  166
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  166

Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala 
1               5                   10                  15      


Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr 
            20                  25                  30          


Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly 
        35                  40                  45              


Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu 
    50                  55                  60                  


Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp 
65                  70                  75                  80  


Thr Ala Val Tyr Tyr Cys Ile Val Arg Gly Ser Pro Gly Ala Gly Gly 
                85                  90                  95      


Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val 
            100                 105                 110         


His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
        115                 120                 125             


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
    130                 135                 140                 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
145                 150                 155                 160 


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
                165                 170                 175     


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
            180                 185                 190         


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
        195                 200                 205             


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
    210                 215                 220                 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
225                 230                 235                 240 


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250     


<210>  167
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  167

Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn 
1               5                   10                  15      


Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln 
        35                  40                  45              


Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val 
    50                  55                  60                  


Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln 
65                  70                  75                  80  


Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser Ser Ile Arg Thr Glu 
                85                  90                  95      


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg 
            100                 105                 110         


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
        115                 120                 125             


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
    130                 135                 140                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
145                 150                 155                 160 


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
                165                 170                 175     


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
            180                 185                 190         


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
        195                 200                 205             


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
    210                 215                 220                 


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
225                 230                 235                 240 


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
                245                 250                 255     


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
            260                 265                 270         


Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280     


<210>  168
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  168

Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln Glu Gly Glu 
1               5                   10                  15      


Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser Asn Ile Gln 
            20                  25                  30          


Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu Ile Gln Leu 
        35                  40                  45              


Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr Phe Gln Phe 
    50                  55                  60                  


Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala Thr Gln Thr 
65                  70                  75                  80  


Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Pro Gly Gly Ala Gly Ser 
                85                  90                  95      


Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val Ile Pro Asn 
            100                 105                 110         


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
        115                 120                 125             


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
    130                 135                 140                 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val 
145                 150                 155                 160 


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
                165                 170                 175     


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
            180                 185                 190         


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
        195                 200                 205             


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val 
    210                 215                 220                 


Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
225                 230                 235                 240 


Met Thr Leu Arg Leu Trp Ser Ser 
                245             


<210>  169
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  169

Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys 
1               5                   10                  15      


Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met 
        35                  40                  45              


Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val 
    50                  55                  60                  


Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Ser 
65                  70                  75                  80  


Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Pro Phe Val Val 
                85                  90                  95      


Ile Gly Gln Ile Asn Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
        115                 120                 125             


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
                165                 170                 175     


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
        195                 200                 205             


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
    210                 215                 220                 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
225                 230                 235                 240 


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
                245                 250                 255     


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
            260                 265                 270         


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285         


<210>  170
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  170

Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln Glu Gly 
1               5                   10                  15      


Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu Phe Val 
        35                  40                  45              


Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met Ala Ser 
    50                  55                  60                  


Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala Ala Val 
65                  70                  75                  80  


His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Ala His Met Asp Ser 
                85                  90                  95      


Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro 
            100                 105                 110         


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
        115                 120                 125             


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
    130                 135                 140                 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
145                 150                 155                 160 


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
                165                 170                 175     


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
            180                 185                 190         


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
        195                 200                 205             


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
    210                 215                 220                 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
225                 230                 235                 240 


Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 


<210>  171
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  171

Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu Lys Thr Gly Gln Ser 
1               5                   10                  15      


Met Thr Leu Leu Cys Ala Gln Asp Met Asn His Glu Tyr Met Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr Ser Val 
        35                  40                  45              


Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro Asp Gly Tyr Asn Val 
    50                  55                  60                  


Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly Leu Glu Ser Ala Ala 
65                  70                  75                  80  


Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ala Gly Leu 
                85                  90                  95      


Ala Ala Pro Arg Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
        115                 120                 125             


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
    130                 135                 140                 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
145                 150                 155                 160 


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
                165                 170                 175     


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            180                 185                 190         


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        195                 200                 205             


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
    210                 215                 220                 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
225                 230                 235                 240 


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                245                 250                 255     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            260                 265                 270         


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285     


<210>  172
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  172

Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala 
1               5                   10                  15      


Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr 
            20                  25                  30          


Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly 
        35                  40                  45              


Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu 
    50                  55                  60                  


Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp 
65                  70                  75                  80  


Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly 
                85                  90                  95      


Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val 
            100                 105                 110         


His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
        115                 120                 125             


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
    130                 135                 140                 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
145                 150                 155                 160 


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
                165                 170                 175     


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
            180                 185                 190         


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
        195                 200                 205             


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
    210                 215                 220                 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
225                 230                 235                 240 


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250     


<210>  173
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  173

Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn 
1               5                   10                  15      


Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln 
        35                  40                  45              


Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val 
    50                  55                  60                  


Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln 
65                  70                  75                  80  


Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Thr Arg Thr Gly Asn Glu 
                85                  90                  95      


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg 
            100                 105                 110         


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
        115                 120                 125             


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
    130                 135                 140                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
145                 150                 155                 160 


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
                165                 170                 175     


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
            180                 185                 190         


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
        195                 200                 205             


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
    210                 215                 220                 


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
225                 230                 235                 240 


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
                245                 250                 255     


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
            260                 265                 270         


Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280     


<210>  174
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  174

Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly Asn 
1               5                   10                  15      


Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr Leu 
            20                  25                  30          


Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu Lys 
        35                  40                  45              


Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu Ala 
    50                  55                  60                  


Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser Ala 
65                  70                  75                  80  


Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Gly Ser 
                85                  90                  95      


Ala Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu 
            100                 105                 110         


Lys Val Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
        115                 120                 125             


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
    130                 135                 140                 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
145                 150                 155                 160 


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
                165                 170                 175     


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
            180                 185                 190         


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
        195                 200                 205             


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
    210                 215                 220                 


Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala 
225                 230                 235                 240 


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250             


<210>  175
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  175

Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly 
1               5                   10                  15      


Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr 
        35                  40                  45              


Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg 
    50                  55                  60                  


Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln 
65                  70                  75                  80  


Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Pro 
                85                  90                  95      


Gly Leu Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
        115                 120                 125             


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
    130                 135                 140                 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
145                 150                 155                 160 


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
                165                 170                 175     


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            180                 185                 190         


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        195                 200                 205             


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
    210                 215                 220                 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
225                 230                 235                 240 


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                245                 250                 255     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            260                 265                 270         


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 285     


<210>  176
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  176

Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu Ser Val Pro Glu 
1               5                   10                  15      


Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn Ser Ala Phe Gln 
            20                  25                  30          


Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly Pro Glu Leu Leu 
        35                  40                  45              


Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly Arg Phe Thr Ala 
    50                  55                  60                  


Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe Ile Arg Asp Ser 
65                  70                  75                  80  


Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Met Ser Gly Leu Lys 
                85                  90                  95      


Glu Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser Gly Thr Arg Leu Leu 
            100                 105                 110         


Val Arg Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
        115                 120                 125             


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
    130                 135                 140                 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
145                 150                 155                 160 


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
                165                 170                 175     


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
            180                 185                 190         


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
        195                 200                 205             


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
    210                 215                 220                 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
225                 230                 235                 240 


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250         


<210>  177
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  177

Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys 
1               5                   10                  15      


Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp 
            20                  25                  30          


Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met 
        35                  40                  45              


Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val 
    50                  55                  60                  


Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Ser 
65                  70                  75                  80  


Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Ile Gln Gln Gly 
                85                  90                  95      


Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
            100                 105                 110         


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
        115                 120                 125             


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
    130                 135                 140                 


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
145                 150                 155                 160 


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
                165                 170                 175     


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
            180                 185                 190         


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
        195                 200                 205             


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
    210                 215                 220                 


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
225                 230                 235                 240 


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
                245                 250                 255     


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
            260                 265                 270         


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        275                 280                 


<210>  178
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Lys Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Leu Arg Asp Asn Asn Ala 
            100                 105                 110         


Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val Val Lys Pro 
        115                 120                 125     


<210>  179
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  179

Met Lys Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Leu Arg Asp Asn Asn Ala 
            100                 105                 110         


Arg Leu Met Phe Gly Asp Gly Thr Gln Leu Val Val Lys Pro Asn Ile 
        115                 120                 125             


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
    130                 135                 140                 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
145                 150                 155                 160 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
                165                 170                 175     


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
            180                 185                 190         


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
        195                 200                 205             


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
    210                 215                 220                 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
225                 230                 235                 240 


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
                245                 250                 255     


Thr Leu Arg Leu Trp Ser Ser 
            260             


<210>  180
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  180

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Gly Leu Val Gly Phe Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
        115                 120                 125             


Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
305                 310                 315                 320 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Leu Val 
                325                 330                 335     


Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met Gly Asp Ala Lys 
            340                 345                 350         


Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu Glu Pro Val His 
        355                 360                 365             


Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp Tyr Ile His Trp 
    370                 375                 380                 


Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val Ile His Gly Leu 
385                 390                 395                 400 


Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala Ile Ala Glu Asp 
                405                 410                 415     


Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr Leu Arg Asp Ala 
            420                 425                 430         


Ala Val Tyr Tyr Cys Ile Leu Arg Asp Asn Asn Ala Arg Leu Met Phe 
        435                 440                 445             


Gly Asp Gly Thr Gln Leu Val Val Lys Pro Asn Ile Gln Asn Pro Glu 
    450                 455                 460                 


Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu 
465                 470                 475                 480 


Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met 
                485                 490                 495     


Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala 
            500                 505                 510         


Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser 
        515                 520                 525             


Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser 
    530                 535                 540                 


Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr 
545                 550                 555                 560 


Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile 
                565                 570                 575     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            580                 585                 590         


Trp Ser Ser 
        595 


<210>  181
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Arg Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro 
    130             


<210>  182
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  182

Met Arg Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  183
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  183

Met Ala Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu 
1               5                   10                  15      


Gly Ala Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu 
            20                  25                  30          


Phe Arg Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu 
        35                  40                  45              


Asn His Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu 
    50                  55                  60                  


Arg Leu Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp 
65                  70                  75                  80  


Ile Ala Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro 
                85                  90                  95      


Leu Thr Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys 
            100                 105                 110         


Ala Ser Leu Gln Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
305                 310                 315                 320 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Leu Val Ala 
                325                 330                 335     


Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile Ile Asp Ala Lys Thr 
            340                 345                 350         


Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala Asn Leu 
        355                 360                 365             


Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr Trp Tyr 
    370                 375                 380                 


Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys 
385                 390                 395                 400 


Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu Asp Arg 
                405                 410                 415     


Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp Thr Ala 
            420                 425                 430         


Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly Thr Ser 
        435                 440                 445             


Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro 
    450                 455                 460                 


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
465                 470                 475                 480 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
                485                 490                 495     


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
            500                 505                 510         


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
        515                 520                 525             


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
    530                 535                 540                 


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
545                 550                 555                 560 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
                565                 570                 575     


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
            580                 585                 590         


Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600     


<210>  184
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Ala Leu Gln Ser Thr Leu Gly Ala Val Trp Leu Gly Leu Leu Leu 
1               5                   10                  15      


Asn Ser Leu Trp Lys Val Ala Glu Ser Lys Asp Gln Val Phe Gln Pro 
            20                  25                  30          


Ser Thr Val Ala Ser Ser Glu Gly Ala Val Val Glu Ile Phe Cys Asn 
        35                  40                  45              


His Ser Val Ser Asn Ala Tyr Asn Phe Phe Trp Tyr Leu His Phe Pro 
    50                  55                  60                  


Gly Cys Ala Pro Arg Leu Leu Val Lys Gly Ser Lys Pro Ser Gln Gln 
65                  70                  75                  80  


Gly Arg Tyr Asn Met Thr Tyr Glu Arg Phe Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Leu Gln Val Arg Glu Ala Asp Ala Ala Val Tyr Tyr Cys Ala Val Glu 
            100                 105                 110         


Asp Arg Arg Arg Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu Ser 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  185
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  185

Met Ala Leu Gln Ser Thr Leu Gly Ala Val Trp Leu Gly Leu Leu Leu 
1               5                   10                  15      


Asn Ser Leu Trp Lys Val Ala Glu Ser Lys Asp Gln Val Phe Gln Pro 
            20                  25                  30          


Ser Thr Val Ala Ser Ser Glu Gly Ala Val Val Glu Ile Phe Cys Asn 
        35                  40                  45              


His Ser Val Ser Asn Ala Tyr Asn Phe Phe Trp Tyr Leu His Phe Pro 
    50                  55                  60                  


Gly Cys Ala Pro Arg Leu Leu Val Lys Gly Ser Lys Pro Ser Gln Gln 
65                  70                  75                  80  


Gly Arg Tyr Asn Met Thr Tyr Glu Arg Phe Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Leu Gln Val Arg Glu Ala Asp Ala Ala Val Tyr Tyr Cys Ala Val Glu 
            100                 105                 110         


Asp Arg Arg Arg Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu Ser 
        115                 120                 125             


Val Ser Ser Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  186
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  186

Met Ala Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Glu Tyr Gln Ser Gln Ser Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
                325                 330                 335     


Leu Gln Ser Thr Leu Gly Ala Val Trp Leu Gly Leu Leu Leu Asn Ser 
            340                 345                 350         


Leu Trp Lys Val Ala Glu Ser Lys Asp Gln Val Phe Gln Pro Ser Thr 
        355                 360                 365             


Val Ala Ser Ser Glu Gly Ala Val Val Glu Ile Phe Cys Asn His Ser 
    370                 375                 380                 


Val Ser Asn Ala Tyr Asn Phe Phe Trp Tyr Leu His Phe Pro Gly Cys 
385                 390                 395                 400 


Ala Pro Arg Leu Leu Val Lys Gly Ser Lys Pro Ser Gln Gln Gly Arg 
                405                 410                 415     


Tyr Asn Met Thr Tyr Glu Arg Phe Ser Ser Ser Leu Leu Ile Leu Gln 
            420                 425                 430         


Val Arg Glu Ala Asp Ala Ala Val Tyr Tyr Cys Ala Val Glu Asp Arg 
        435                 440                 445             


Arg Arg Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu Ser Val Ser 
    450                 455                 460                 


Ser Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
465                 470                 475                 480 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                485                 490                 495     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            500                 505                 510         


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        515                 520                 525             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    530                 535                 540                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
545                 550                 555                 560 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                565                 570                 575     


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            580                 585                 590         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600         


<210>  187
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Arg Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Gly Ser Pro Gly 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro 
    130             


<210>  188
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  188

Met Arg Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Gly Ser Pro Gly 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  189
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  189

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ile Arg Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala 
    290                 295                 300                 


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
305                 310                 315                 320 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Leu Val Ala Arg Val 
                325                 330                 335     


Thr Val Phe Leu Thr Phe Gly Thr Ile Ile Asp Ala Lys Thr Thr Gln 
            340                 345                 350         


Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala Asn Leu Pro Cys 
        355                 360                 365             


Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr Trp Tyr Arg Gln 
    370                 375                 380                 


Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys Asn Asn 
385                 390                 395                 400 


Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu Asp Arg Lys Ser 
                405                 410                 415     


Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp Thr Ala Val Tyr 
            420                 425                 430         


Tyr Cys Ile Val Arg Gly Ser Pro Gly Ala Gly Gly Thr Ser Tyr Gly 
        435                 440                 445             


Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile 
    450                 455                 460                 


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
465                 470                 475                 480 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
                485                 490                 495     


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
            500                 505                 510         


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
        515                 520                 525             


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
    530                 535                 540                 


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
545                 550                 555                 560 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
                565                 570                 575     


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
            580                 585                 590         


Thr Leu Arg Leu Trp Ser Ser 
        595                 


<210>  190
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Leu Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      


Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          


Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              


Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  


Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Pro Gly Gly 
            100                 105                 110         


Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val 
        115                 120                 125             


Ile Pro 
    130 


<210>  191
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  191

Met Leu Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln 
1               5                   10                  15      


Val Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln 
            20                  25                  30          


Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser 
        35                  40                  45              


Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu 
    50                  55                  60                  


Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Pro Gly Gly 
            100                 105                 110         


Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val 
        115                 120                 125             


Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  192
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  192

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Phe Val Val Ile Gly Gln Ile Asn Glu Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


Leu Leu Ile Thr Ser Met Leu Val Leu Trp Met Gln Leu Ser Gln Val 
            340                 345                 350         


Asn Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln His Val Gln Glu 
        355                 360                 365             


Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr Thr Leu Ser Asn 
    370                 375                 380                 


Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro Val Phe Leu Ile 
385                 390                 395                 400 


Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys Arg Leu Thr Phe 
                405                 410                 415     


Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His Ile Thr Ala Thr 
            420                 425                 430         


Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly Pro Gly Gly Ala 
        435                 440                 445             


Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val Ile 
    450                 455                 460                 


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
465                 470                 475                 480 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                485                 490                 495     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            500                 505                 510         


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        515                 520                 525             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    530                 535                 540                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
545                 550                 555                 560 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                565                 570                 575     


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            580                 585                 590         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600         


<210>  193
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Lys Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu 
1               5                   10                  15      


Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln 
            20                  25                  30          


Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp 
        35                  40                  45              


Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu 
    50                  55                  60                  


Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met 
65                  70                  75                  80  


Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala 
                85                  90                  95      


Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Ala His Met 
            100                 105                 110         


Asp Ser Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile 
        115                 120                 125             


Lys Pro 
    130 


<210>  194
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  194

Met Lys Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu 
1               5                   10                  15      


Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln 
            20                  25                  30          


Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp 
        35                  40                  45              


Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu 
    50                  55                  60                  


Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met 
65                  70                  75                  80  


Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala 
                85                  90                  95      


Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Ala His Met 
            100                 105                 110         


Asp Ser Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile 
        115                 120                 125             


Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  195
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  195

Met Ala Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Ala Gly Leu Ala Ala Pro Arg Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys 
                325                 330                 335     


Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu Ser Gly 
            340                 345                 350         


Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln Glu Gly 
        355                 360                 365             


Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp Arg Leu 
    370                 375                 380                 


Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu Phe Val 
385                 390                 395                 400 


Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met Ala Ser 
                405                 410                 415     


Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala Ala Val 
            420                 425                 430         


His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Ala His Met Asp Ser 
        435                 440                 445             


Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro 
    450                 455                 460                 


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
465                 470                 475                 480 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
                485                 490                 495     


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
            500                 505                 510         


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
        515                 520                 525             


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
    530                 535                 540                 


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
545                 550                 555                 560 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
                565                 570                 575     


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
            580                 585                 590         


Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600     


<210>  196
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Arg Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro 
    130             


<210>  197
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  197

Met Arg Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Arg Ala Arg Ala Asn 
            100                 105                 110         


Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly Thr Ile 
        115                 120                 125             


Leu Thr Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  198
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  198

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Thr 
            100                 105                 110         


Arg Thr Gly Asn Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala 
    290                 295                 300                 


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
305                 310                 315                 320 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Leu Val Ala Arg Val 
                325                 330                 335     


Thr Val Phe Leu Thr Phe Gly Thr Ile Ile Asp Ala Lys Thr Thr Gln 
            340                 345                 350         


Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala Asn Leu Pro Cys 
        355                 360                 365             


Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr Trp Tyr Arg Gln 
    370                 375                 380                 


Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys Asn Asn 
385                 390                 395                 400 


Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu Asp Arg Lys Ser 
                405                 410                 415     


Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp Thr Ala Val Tyr 
            420                 425                 430         


Tyr Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly Thr Ser Tyr Gly 
        435                 440                 445             


Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile 
    450                 455                 460                 


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
465                 470                 475                 480 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
                485                 490                 495     


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
            500                 505                 510         


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
        515                 520                 525             


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
    530                 535                 540                 


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
545                 550                 555                 560 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
                565                 570                 575     


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
            580                 585                 590         


Thr Leu Arg Leu Trp Ser Ser 
        595                 


<210>  199
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Gly Ser Ala Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr 
        115                 120                 125             


Gly Thr Arg Leu Lys Val Leu Ala 
    130                 135     


<210>  200
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  200

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Gly Ser Ala Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr 
        115                 120                 125             


Gly Thr Arg Leu Lys Val Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  201
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  201

Met Ala Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Leu Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
305                 310                 315                 320 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Ser Ala 
                325                 330                 335     


Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser Gly Leu Arg Ala 
            340                 345                 350         


Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val Ala Glu Gly Asn 
        355                 360                 365             


Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly Asn Pro Tyr Leu 
    370                 375                 380                 


Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu Lys 
385                 390                 395                 400 


Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr Gly Phe Glu Ala 
                405                 410                 415     


Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys Lys Pro Ser Ala 
            420                 425                 430         


Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val Arg Asp Gly Ser 
        435                 440                 445             


Ala Thr Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu 
    450                 455                 460                 


Lys Val Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
465                 470                 475                 480 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
                485                 490                 495     


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
            500                 505                 510         


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
        515                 520                 525             


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
    530                 535                 540                 


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
545                 550                 555                 560 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
                565                 570                 575     


Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala 
            580                 585                 590         


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605 


<210>  202
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu 
    130         


<210>  203
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  203

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  204
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  204

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Ser Gly Leu Lys Glu Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Arg Pro Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Pro Gln 
    290                 295                 300                 


Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala Gly Pro Leu Glu 
305                 310                 315                 320 


Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys 
                325                 330                 335     


Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser 
            340                 345                 350         


Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser 
        355                 360                 365             


Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys 
    370                 375                 380                 


Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro 
385                 390                 395                 400 


Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Ile Gln Gln 
                405                 410                 415     


Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            420                 425                 430         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        435                 440                 445             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    450                 455                 460                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
465                 470                 475                 480 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                485                 490                 495     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    530                 535                 540                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605 


<210>  205
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Gly Leu Val Gly Phe Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
        115                 120                 125             


Leu Ser Ile Leu 
    130         


<210>  206
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  206

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Gly Leu Val Gly Phe Asn Gln Pro Gln His Phe Gly Asp Gly Thr Arg 
        115                 120                 125             


Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  207
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Leu Gln Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu 
    


<210>  208
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  208

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Leu Gln Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  209
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Glu Tyr Gln Ser Gln Ser Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  210
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  210

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Glu Tyr Gln Ser Gln Ser Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  211
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ile Arg Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val 
    


<210>  212
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  212

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ile Arg Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  213
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Phe Val Val Ile Gly Gln Ile Asn Glu Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Thr 
    130                 135 


<210>  214
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  214

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Phe Val Val Ile Gly Gln Ile Asn Glu Gln Tyr Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser 
305             


<210>  215
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Ser Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Ala Gly Leu Ala Ala Pro Arg Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  216
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  216

Met Ser Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Ala Gly Leu Ala Ala Pro Arg Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  217
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Thr 
            100                 105                 110         


Arg Thr Gly Asn Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val 
    


<210>  218
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  218

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Thr 
            100                 105                 110         


Arg Thr Gly Asn Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  219
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Leu Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr 
    130         


<210>  220
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  220

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Gly Leu Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  221
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  221

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu 
    130         


<210>  222
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  222

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  223
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  223

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Ser Gly Leu Lys Glu Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Arg Pro 
    130                 135     


<210>  224
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  224

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Ser Gly Leu Lys Glu Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser 
        115                 120                 125             


Gly Thr Arg Leu Leu Val Arg Pro Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  225
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  225

Met Ala Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
305                 310                 315                 320 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Met Lys Ser 
                325                 330                 335     


Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser Trp Val Trp 
            340                 345                 350         


Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro Leu Ser Val Pro 
        355                 360                 365             


Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser Asn Ser Ala Phe 
    370                 375                 380                 


Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys Gly Pro Glu Leu 
385                 390                 395                 400 


Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp Gly Arg Phe Thr 
                405                 410                 415     


Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu Phe Ile Arg Asp 
            420                 425                 430         


Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Met Ser Gly Leu 
        435                 440                 445             


Lys Glu Asp Ser Ser Tyr Lys Leu Ile Phe Gly Ser Gly Thr Arg Leu 
    450                 455                 460                 


Leu Val Arg Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
465                 470                 475                 480 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
                485                 490                 495     


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
            500                 505                 510         


Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
        515                 520                 525             


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
    530                 535                 540                 


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
545                 550                 555                 560 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
                565                 570                 575     


Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala 
            580                 585                 590         


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605 


<210>  226
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  226

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Leu Gln Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu 
    


<210>  227
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  227

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Leu Gln Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  228
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  228

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Leu Gln Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala 
    290                 295                 300                 


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
305                 310                 315                 320 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Val Ala Arg Val 
                325                 330                 335     


Thr Val Phe Leu Thr Phe Gly Thr Ile Ile Asp Ala Lys Thr Thr Gln 
            340                 345                 350         


Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala Asn Leu Pro Cys 
        355                 360                 365             


Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr Trp Tyr Arg Gln 
    370                 375                 380                 


Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys Asn Asn 
385                 390                 395                 400 


Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu Asp Arg Lys Ser 
                405                 410                 415     


Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp Thr Ala Val Tyr 
            420                 425                 430         


Tyr Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly Thr Ser Tyr Gly 
        435                 440                 445             


Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile 
    450                 455                 460                 


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
465                 470                 475                 480 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
                485                 490                 495     


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
            500                 505                 510         


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
        515                 520                 525             


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
    530                 535                 540                 


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
545                 550                 555                 560 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
                565                 570                 575     


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
            580                 585                 590         


Thr Leu Arg Leu Trp Ser Ser 
        595                 


<210>  229
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  229

Met Ala Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Leu Gln Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala 
    290                 295                 300                 


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
305                 310                 315                 320 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Leu Val Ala Arg Val 
                325                 330                 335     


Thr Val Phe Leu Thr Phe Gly Thr Ile Ile Asp Ala Lys Thr Thr Gln 
            340                 345                 350         


Pro Pro Ser Met Asp Cys Ala Glu Gly Arg Ala Ala Asn Leu Pro Cys 
        355                 360                 365             


Asn His Ser Thr Ile Ser Gly Asn Glu Tyr Val Tyr Trp Tyr Arg Gln 
    370                 375                 380                 


Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys Asn Asn 
385                 390                 395                 400 


Glu Thr Asn Glu Met Ala Ser Leu Ile Ile Thr Glu Asp Arg Lys Ser 
                405                 410                 415     


Ser Thr Leu Ile Leu Pro His Ala Thr Leu Arg Asp Thr Ala Val Tyr 
            420                 425                 430         


Tyr Cys Ile Val Arg Ala Arg Ala Asn Ala Gly Gly Thr Ser Tyr Gly 
        435                 440                 445             


Lys Leu Thr Phe Gly Gln Gly Thr Ile Leu Thr Val His Pro Asn Ile 
    450                 455                 460                 


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
465                 470                 475                 480 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
                485                 490                 495     


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
            500                 505                 510         


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
        515                 520                 525             


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
    530                 535                 540                 


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
545                 550                 555                 560 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
                565                 570                 575     


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
            580                 585                 590         


Thr Leu Arg Leu Trp Ser Ser 
        595                 


<210>  230
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  230

Arg Ala Lys Arg 
1               


