﻿                         序列表

<110>  中国人民解放军军事科学院军事医学研究院

<120>  一种单克隆抗体10G12及其应用

<160>  20

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  351
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  1
caggtgcagc tgaagcagcc tggggctgag ctggtgaggc ctggagcttc agtgaagctg        60
tcctgcaagg cttctggtta ctcattcacc aactactgga tgcactggat gaagcagagg       120
cctggacaag gtcttgagtg gattggcatg attgatcctt ccgatagtga aactaggtta       180
aatcagaagt tcaaggacaa ggccacattg actgtagaca aatcctccag tatagcctac       240
atgcaactca gcagcccgac atctgaggac tctgcggtct attactgtgc aagagatagg       300
tacgacggag gggcctggtt tgattactgg agccaaggga ctctggtcac t                351

<210>  2
<211>  117
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Gln Val Gln Leu Lys Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          
Trp Met His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Ile Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Asp Gly Gly Ala Trp Phe Asp Tyr Trp Ser Gln 
            100                 105                 110         
Gly Thr Leu Val Thr 
        115         

<210>  3
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  3
gacattgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc        60
atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg       120
tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt       180
tctggggtcc cagacaggtt cagcgtcagt ggatcaggga cagatttcac actcaagatc       240
agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcct       300
ccgacgttcg gtggaggcac caagctggaa atcaaa                                 336

<210>  4
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Val Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  5
<211>  360
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  5
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg        60
tcctgcaagg ccagcggcta cagcttcacc aactactgga tgcactgggt ccgacaggcc       120
cctggacaag gacttgagtg gatgggcatc atcgacccca gcgacagcga gacaaggctg       180
aaccagaaat tcaaggaccg cgtgaccatg accagagaca ccagcacctc caccgtgtac       240
atggaactga gcagcctgag aagcgaggac accgccgtgt actactgcgc cagagacaga       300
tatgatggcg gcgcttggtt tgactactgg ggccagggaa cactggtcac cgttagctct       360

<210>  6
<211>  120
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Asp Gly Gly Ala Trp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210>  7
<211>  360
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  7
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg        60
tcctgcaagg ccagcggcta cagcttcacc aactactgga tgcactgggt ccgacaggcc       120
cctggacaag gacttgagtg gatgggcatc atcgacccca gcgacagcga gacaaggctg       180
aaccagaaat tcaaggaccg cgtgaccata accgcagaca agagcacctc caccgcgtac       240
atggaactga gcagcctgag aagcgaggac accgccgtgt actactgcgc cagagacaga       300
tatgatggcg gcgcttggtt tgactactgg ggccagggaa cactggtcac cgttagctct       360

<210>  8
<211>  120
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Asp Gly Gly Ala Trp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210>  9
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  9
gacgtggtca tgacacagag ccctctgagc ctgcctgtga cacttggaca gcctgccagc        60
atcagctgca gatctagcca gagcctggtg cacagcaacg gcaacaccta cctgaactgg       120
ttccagcaga ggcccggaca gtctcctaga cggctgatct acaaggtgtc caacagagac       180
agcggcgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgaagatc       240
agcagagtgg aagccgagga cgtgggcgtg tactactgta gccagtctac ccatgtgcct       300
ccaacctttg gcggaggcac caaggtggaa atcaag                                 336

<210>  10
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  10
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  11
<211>  1368
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  11
caggtgcagc tgaagcagcc tggggctgag ctggtgaggc ctggagcttc agtgaagctg        60
tcctgcaagg cttctggtta ctcattcacc aactactgga tgcactggat gaagcagagg       120
cctggacaag gtcttgagtg gattggcatg attgatcctt ccgatagtga aactaggtta       180
aatcagaagt tcaaggacaa ggccacattg actgtagaca aatcctccag tatagcctac       240
atgcaactca gcagcccgac atctgaggac tctgcggtct attactgtgc aagagatagg       300
tacgacggag gggcctggtt tgattactgg agccaaggga ctctggtcac tgtctctagc       360
gctaaaacaa cacccccatc agtctatcca ctggcccctg ggtgtggaga tacaactggt       420
tcctccgtga ctctgggatg cctggtcaag ggctacttcc ctgagtcagt gactgtgact       480
tggaactctg gatccctgtc cagcagtgtg cacaccttcc cagctctcct gcagtctgga       540
ctctacacta tgagcagctc agtgactgtc ccctccagca cctggccaag tcagaccgtc       600
acctgcagcg ttgctcaccc agccagcagc accacggtgg acaaaaaact tgagcccagc       660
gggcccattt caacaatcaa cccctgtcct ccatgcaagg agtgtcacaa atgcccagct       720
cctaacctcg agggtggacc atccgtcttc atcttccctc caaatatcaa ggatgtactc       780
atgatctccc tgacacccaa ggtcacgtgt gtggtggtgg atgtgagcga ggatgaccca       840
gacgtccaga tcagctggtt tgtgaacaac gtggaagtac acacagctca gacacaaacc       900
catagagagg attacaacag tactatccgg gtggtcagca ccctccccat ccagcaccag       960
gactggatga gtggcaagga gttcaaatgc aaggtcaaca acaaagacct cccatcaccc      1020
atcgagagaa ccatctcaaa aattaaaggg ctagtcagag ctccacaagt atacatcttg      1080
ccgccaccag cagagcagtt gtccaggaaa gatgtcagtc tcacttgcct ggtcgtgggc      1140
ttcaaccctg gagacatcag tgtggagtgg accagcaatg ggcatacaga ggagaactac      1200
aaggacaccg caccagtcct ggactctgac ggttcttact tcatatatag caagctcaat      1260
atgaaaacaa gcaagtggga gaaaacagat tccttctcat gcaacgtgag acacgagggt      1320
ctgaaaaatt actacctgaa gaagaccatc tcccggtctc cgggtaaa                   1368

<210>  12
<211>  456
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Gln Val Gln Leu Lys Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          
Trp Met His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Ile Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Asp Gly Gly Ala Trp Phe Asp Tyr Trp Ser Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val 
        115                 120                 125             
Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr 
145                 150                 155                 160 
Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu 
                165                 170                 175     
Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser 
            180                 185                 190         
Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro Ala 
        195                 200                 205             
Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser 
    210                 215                 220                 
Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala 
225                 230                 235                 240 
Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile 
                245                 250                 255     
Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val 
            260                 265                 270         
Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
        275                 280                 285             
Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
    290                 295                 300                 
Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His Gln 
305                 310                 315                 320 
Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
                325                 330                 335     
Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val 
            340                 345                 350         
Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser 
        355                 360                 365             
Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly 
    370                 375                 380                 
Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr 
385                 390                 395                 400 
Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr 
                405                 410                 415     
Ser Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe 
            420                 425                 430         
Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys 
        435                 440                 445             
Thr Ile Ser Arg Ser Pro Gly Lys 
    450                 455     

<210>  13
<211>  657
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  13
gacattgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc        60
atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg       120
tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt       180
tctggggtcc cagacaggtt cagcgtcagt ggatcaggga cagatttcac actcaagatc       240
agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcct       300
ccgacgttcg gtggaggcac caagctggaa atcaaacgtg ctgatgctgc accaactgta       360
tccatcttcc caccatccag tgagcagtta acatctggag gtgcctcagt cgtgtgcttc       420
ttgaacaact tctacccgaa agacatcaat gtcaagtgga agattgatgg cagtgaacgt       480
caaaatggcg tcctgaacag ttggactgat caggacagca aagacagcac ctacagcatg       540
agcagcaccc tcacgttgac caaggacgag tatgaacgcc ataacagcta tacctgtgag       600
gccactcaca agacatcaac ttcaccgatt gtcaagagct tcaaccgtaa tgagtgt          657

<210>  14
<211>  219
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  14
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Val Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         
Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             
Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 

<210>  15
<211>  1350
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  15
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg        60
tcctgcaagg ccagcggcta cagcttcacc aactactgga tgcactgggt ccgacaggcc       120
cctggacaag gacttgagtg gatgggcatc atcgacccca gcgacagcga gacaaggctg       180
aaccagaaat tcaaggaccg cgtgaccatg accagagaca ccagcacctc caccgtgtac       240
atggaactga gcagcctgag aagcgaggac accgccgtgt actactgcgc cagagacaga       300
tatgatggcg gcgcttggtt tgactactgg ggccagggaa cactggtcac cgttagctct       360
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       420
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       480
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       540
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       600
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc       660
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga       720
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       780
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       840
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       900
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       960
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      1020
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      1080
atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      1140
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      1200
ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      1260
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      1320
cagaagagcc tctccctgtc cccgggtaaa                                       1350

<210>  16
<211>  450
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  16
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Asp Gly Gly Ala Trp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
Gly Lys 
    450 

<210>  17
<211>  657
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  17
gacgtggtca tgacacagag ccctctgagc ctgcctgtga cacttggaca gcctgccagc        60
atcagctgca gatctagcca gagcctggtg cacagcaacg gcaacaccta cctgaactgg       120
ttccagcaga ggcccggaca gtctcctaga cggctgatct acaaggtgtc caacagagac       180
agcggcgtgc ccgatagatt ttctggcagc ggctctggca ccgacttcac cctgaagatc       240
agcagagtgg aagccgagga cgtgggcgtg tactactgta gccagtctac ccatgtgcct       300
ccaacctttg gcggaggcac caaggtggaa atcaagcgta cggtggcggc gccatctgtc       360
ttcatcttcc cgccatctga tgagcagttg aaatctggta ccgctagcgt tgtgtgcctg       420
ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa       480
tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc       540
agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa       600
gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt          657

<210>  18
<211>  219
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  18
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210>  19
<211>  1350
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  19
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg        60
tcctgcaagg ccagcggcta cagcttcacc aactactgga tgcactgggt ccgacaggcc       120
cctggacaag gacttgagtg gatgggcatc atcgacccca gcgacagcga gacaaggctg       180
aaccagaaat tcaaggaccg cgtgaccata accgcagaca agagcacctc caccgcgtac       240
atggaactga gcagcctgag aagcgaggac accgccgtgt actactgcgc cagagacaga       300
tatgatggcg gcgcttggtt tgactactgg ggccagggaa cactggtcac cgttagctct       360
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       420
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg       480
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca       540
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc       600
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc       660
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga       720
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       780
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg       840
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac       900
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag       960
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      1020
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      1080
atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      1140
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      1200
ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      1260
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      1320
cagaagagcc tctccctgtc cccgggtaaa                                       1350

<210>  20
<211>  450
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  20
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  
Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Asp Gly Gly Ala Trp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             
Gly Lys 
    450 

