                         SEQUENCE LISTING

<110>  Medigene Immunotherapies GmbH
 
<120>  MAGEA10 specific T cell receptors and their use

<130>  M11465WO / DB

<150>  EP19185192
<151>  2019-07-09

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Leu Leu Lys Phe Leu Ala Lys Val 
1               5                   


<210>  2
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  2

Asn Ser Met Phe Asp Tyr 
1               5       


<210>  3
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Ser Ser Ile Lys Asp Lys 
1               5           


<210>  4
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Ala Ala Asn Ser Asn Ser Gly Tyr Ala Leu Asn Phe 
1               5                   10              


<210>  5
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Gly His Asp Arg 
1               5   


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Phe Asp Val Lys Asp 
1               5       


<210>  7
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Ala Thr Gly Asp Pro Leu Gln Glu Thr Gln Tyr Phe 
1               5                   10              


<210>  8
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro 
1               5                   10                  15      


Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln 
            20                  25                  30          


Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn 
        35                  40                  45              


Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys 
    50                  55                  60                  


Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys 
65                  70                  75                  80  


Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala 
                85                  90                  95      


Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Asn Ser Asn Ser Gly Tyr Ala Leu Asn Phe 
        115                 120                 125             


Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His 
    130                 135                 


<210>  9
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Gly Asp Pro Leu Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Leu 
    130     


<210>  10
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  with murinized constant region

<400>  10

Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro 
1               5                   10                  15      


Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln 
            20                  25                  30          


Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn 
        35                  40                  45              


Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys 
    50                  55                  60                  


Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys 
65                  70                  75                  80  


Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala 
                85                  90                  95      


Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Asn Ser Asn Ser Gly Tyr Ala Leu Asn Phe 
        115                 120                 125             


Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His Ile Gln Asn Pro Glu 
    130                 135                 140                 


Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu 
145                 150                 155                 160 


Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met 
                165                 170                 175     


Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala 
            180                 185                 190         


Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser 
        195                 200                 205             


Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser 
    210                 215                 220                 


Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210>  11
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  with murinized constant region

<400>  11

Met Ala Ser Leu Leu Phe Phe Cys Gly Ala Phe Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Gly Ser Met Asp Ala Asp Val Thr Gln Thr Pro Arg Asn Arg Ile Thr 
            20                  25                  30          


Lys Thr Gly Lys Arg Ile Met Leu Glu Cys Ser Gln Thr Lys Gly His 
        35                  40                  45              


Asp Arg Met Tyr Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Phe Asp Val Lys Asp Ile Asn Lys Gly Glu Ile Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Gln Ala Gln Ala Lys Phe Ser Leu Ser 
                85                  90                  95      


Leu Glu Ser Ala Ile Pro Asn Gln Thr Ala Leu Tyr Phe Cys Ala Thr 
            100                 105                 110         


Gly Asp Pro Leu Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Thr Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300                 


<210>  12
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  12
aactctatgt tcgactac                                                     18


<210>  13
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  13
atcagcagca tcaaggacaa g                                                 21


<210>  14
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  14
tgcgccgcca atagcaatag cggctacgcc ctgaatttc                              39


<210>  15
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  15
aagggccacg accgg                                                        15


<210>  16
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  16
agcttcgacg tgaaggac                                                     18


<210>  17
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  17
tgcgccactg gcgaccctct gcaagagaca cagtatttc                              39


<210>  18
<211>  415
<212>  DNA
<213>  Homo sapiens

<400>  18
atggctatgc tgctgggagc ctctgtgctg atcctgtggc tgcaacccga ttgggtcaac       60

agccagcaga agaacgacga ccagcaagtg aagcagaaca gccccagcct gagcgtgcaa      120

gagggcagaa tcagcatcct gaactgcgac tacaccaact ctatgttcga ctacttcctg      180

tggtacaaga agtaccccgc cgagggaccg accttcctga tcagcatcag cagcatcaag      240

gacaagaacg aggacggccg gttcaccgtg tttctgaaca agagcgccaa gcacctgagc      300

ctgcacatcg tgccttctca gcctggcgat agcgccgtgt atttctgcgc cgccaatagc      360

aatagcggct acgccctgaa tttcggcaag ggcacaagcc tgctggtcac ccctc           415


<210>  19
<211>  394
<212>  DNA
<213>  Homo sapiens

<400>  19
atggccagcc tgctgttctt ctgcggcgcc ttttatctgc tcggcaccgg ctctatggac       60

gccgacgtta cacagacccc tcggaacaga atcaccaaga ccggcaagcg gatcatgctg      120

gaatgcagcc agaccaaggg ccacgaccgg atgtactggt acagacagga tccaggactg      180

ggcctgagac tgatctacta cagcttcgac gtgaaggaca tcaacaaggg cgagatcagc      240

gacggctaca gcgtgtcaag acaggcccag gccaagttca gcctgagcct ggaaagcgct      300

atccccaacc agacagccct gtacttctgc gccactggcg accctctgca agagacacag      360

tatttcggcc ctggcaccag actgctggtt ctgg                                  394


<210>  20
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  with murinized constant region; codon optimized

<400>  20
atggctatgc tgctgggagc ctctgtgctg atcctgtggc tgcaacccga ttgggtcaac       60

agccagcaga agaacgacga ccagcaagtg aagcagaaca gccccagcct gagcgtgcaa      120

gagggcagaa tcagcatcct gaactgcgac tacaccaact ctatgttcga ctacttcctg      180

tggtacaaga agtaccccgc cgagggaccg accttcctga tcagcatcag cagcatcaag      240

gacaagaacg aggacggccg gttcaccgtg tttctgaaca agagcgccaa gcacctgagc      300

ctgcacatcg tgccttctca gcctggcgat agcgccgtgt atttctgcgc cgccaatagc      360

aatagcggct acgccctgaa tttcggcaag ggcacaagcc tgctggtcac ccctcacatc      420

cagaatccgg agcccgccgt ataccagctg aaggacccta gaagccagga cagcaccctg      480

tgcctgttca ccgacttcga cagccagatc aacgtgccca agaccatgga aagcggcacc      540

ttcatcaccg acaagacagt gctggacatg aaggccatgg acagcaagtc caacggcgca      600

atcgcctggt ccaaccagac cagcttcaca tgccaggaca tcttcaaaga gacaaacgcc      660

acatacccca gcagcgacgt gccctgtgat gccaccctga cagagaagtc cttcgagaca      720

gacatgaacc tgaacttcca gaatctgtcc gtgatgggcc tgagaatcct gctgctgaag      780

gtggccggct tcaatctgct gatgaccctg cggctgtggt ccagc                      825


<210>  21
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  with murinized constant region; codon optimized

<400>  21
atggccagcc tgctgttctt ctgcggcgcc ttttatctgc tcggcaccgg ctctatggac       60

gccgacgtta cacagacccc tcggaacaga atcaccaaga ccggcaagcg gatcatgctg      120

gaatgcagcc agaccaaggg ccacgaccgg atgtactggt acagacagga tccaggactg      180

ggcctgagac tgatctacta cagcttcgac gtgaaggaca tcaacaaggg cgagatcagc      240

gacggctaca gcgtgtcaag acaggcccag gccaagttca gcctgagcct ggaaagcgct      300

atccccaacc agacagccct gtacttctgc gccactggcg accctctgca agagacacag      360

tatttcggcc ctggcaccag actgctggtt ctggaagatc tccggaacgt gaccccccct      420

aaagtgaccc tgttcgaacc cagcaaggcc gagatcgcca acaagcagaa agccaccctc      480

gtgtgcctgg ccagaggctt cttccccgac catgtggaac tgtcttggtg ggtcaacggc      540

aaagaggtgc acagcggagt gtccaccgac cctcaggcct acaaagagag caactacagc      600

tactgcctga gcagcagact gcgggtgtcc gccaccttct ggcacaaccc ccggaaccac      660

ttcagatgcc aggtgcagtt tcacggcctg agcgaagagg acaagtggcc cgaaggctcc      720

cccaagcccg tgacccagaa tatctctgcc gaggcctggg gcagagccga ctgtggaatt      780

accagcgcca gctaccacca gggcgtgctg tctgccacca tcctgtacga gatcctgctg      840

ggcaaggcca ccctgtacgc cgtgctggtg tctggcctgg tgctgatggc catggtcaag      900

aagaagaaca gc                                                          912


<210>  22
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  22

Lys Leu Tyr Gly Leu Asp Trp Ala Glu Leu 
1               5                   10  


<210>  23
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  23

Pro Arg Ala His Ala Glu Ile Arg Lys Met Ser Leu Leu Lys Phe Leu 
1               5                   10                  15      


Ala Lys Val Asn Gly Ser Asp Pro Arg Ser Phe Pro Leu 
            20                  25                  


