               SEQUENCE LISTING

<110> GENETHON
      INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
      (INSERM)
      UNIVERSITE D'EVRY VAL D'ESSONNE

<120> Treatment of glycogen storage disease (GSD)

<130> 1H274440  0001 PCT /NIM/AGI

<140> EP19 305 928.4
<141> 2019-07-09

<150> EP19305928.4
<151> 2019-07-09

<160> 55

<170> BiSSAP 1.3.6

<210> 1
<211> 925
<212> PRT
<213> artificial


<220> 
<223> hGAAwt w/o sp

<400> 1
Gly His Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser 
1               5                   10                  15      
Gly Ser Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly 
            20                  25                  30          
Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro 
        35                  40                  45              
Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp 
    50                  55                  60                  
Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly 
65                  70                  75                  80  
Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly 
                85                  90                  95      
Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu 
            100                 105                 110         
Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr 
        115                 120                 125             
Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val 
    130                 135                 140                 
Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala 
145                 150                 155                 160 
Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg 
                165                 170                 175     
Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly 
            180                 185                 190         
Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr 
        195                 200                 205             
Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser 
    210                 215                 220                 
Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu 
225                 230                 235                 240 
Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu 
                245                 250                 255     
Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu 
            260                 265                 270         
Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser 
        275                 280                 285             
Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg 
    290                 295                 300                 
Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro 
305                 310                 315                 320 
Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met 
                325                 330                 335     
Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser 
            340                 345                 350         
Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His 
        355                 360                 365             
Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg 
    370                 375                 380                 
Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met 
385                 390                 395                 400 
Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp 
                405                 410                 415     
Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp 
            420                 425                 430         
Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro 
        435                 440                 445             
Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr 
    450                 455                 460                 
Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His 
465                 470                 475                 480 
Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser 
                485                 490                 495     
Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu 
            500                 505                 510         
Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala 
        515                 520                 525             
Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu 
    530                 535                 540                 
His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu 
545                 550                 555                 560 
Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe 
                565                 570                 575     
Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser 
            580                 585                 590         
Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn 
        595                 600                 605             
Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly 
    610                 615                 620                 
Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe 
625                 630                 635                 640 
Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu 
                645                 650                 655     
Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu 
            660                 665                 670         
Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln 
        675                 680                 685             
Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe 
    690                 695                 700                 
Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly 
705                 710                 715                 720 
Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val 
                725                 730                 735     
Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro 
            740                 745                 750         
Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu 
        755                 760                 765             
Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu 
    770                 775                 780                 
Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln 
785                 790                 795                 800 
Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu 
                805                 810                 815     
Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp 
            820                 825                 830         
Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln 
        835                 840                 845             
Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg 
    850                 855                 860                 
Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu 
865                 870                 875                 880 
Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val 
                885                 890                 895     
Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val 
            900                 905                 910         
Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
        915                 920                 925 

<210> 2
<211> 952
<212> PRT
<213> homo sapiens


<400> 2
Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      
Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          
His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              
Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  
Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  
Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      
Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         
Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             
Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 
Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 
Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     
Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         
Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             
Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 
Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 
Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     
Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         
Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             
Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 
Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 
Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     
Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         
Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             
Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 
Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 
Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     
Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         
Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             
Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 
Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 
Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     
Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         
Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             
Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 
Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 
Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     
Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         
Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             
Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 
Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 
Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     
Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         
Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             
Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 
Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 
Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     
Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         
Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             
Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 
Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 
Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     
His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         
Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             
Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 
Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 
Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     
Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         
Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             
Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 
Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         

<210> 3
<211> 18
<212> PRT
<213> artificial


<220> 
<223> sp7

<400> 3
Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      
Phe Gly 
        

<210> 4
<211> 27
<212> PRT
<213> artificial


<220> 
<223> sp1

<400> 4
Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      
Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu 
            20                  25          

<210> 5
<211> 24
<212> PRT
<213> artificial


<220> 
<223> sp2

<400> 5
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      
Cys Leu Val Pro Val Ser Leu Ala 
            20                  

<210> 6
<211> 25
<212> PRT
<213> artificial


<220> 
<223> sp6

<400> 6
Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      
Leu Ser Ser Val Cys Val Ala Leu Gly 
            20                  25  

<210> 7
<211> 22
<212> PRT
<213> artificial


<220> 
<223> sp8

<400> 7
Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      
Gly Asp Arg Ala Ser Ser 
            20          

<210> 8
<211> 2859
<212> DNA
<213> homo sapiens


<400> 8
atgggagtga ggcacccgcc ctgctcccac cggctcctgg ccgtctgcgc cctcgtgtcc      60

ttggcaaccg cagcgctcct ggggcacatc ctactccatg atttcctgct ggttccccga     120

gagctgagtg gctcctcccc agtcctggag gagactcacc cagctcacca gcagggagcc     180

agcagaccag ggccccggga tgcccaggca caccccgggc ggccgcgagc agtgcccaca     240

cagtgcgacg tcccccccaa cagccgcttc gattgcgccc ctgacaaggc catcacccag     300

gaacagtgcg aggcccgcgg ctgttgctac atccctgcaa agcaggggct gcagggagcc     360

cagatggggc agccctggtg cttcttccca cccagctacc ccagctacaa gctggagaac     420

ctgagctcct ctgaaatggg ctacacggcc accctgaccc gtaccacccc caccttcttc     480

cccaaggaca tcctgaccct gcggctggac gtgatgatgg agactgagaa ccgcctccac     540

ttcacgatca aagatccagc taacaggcgc tacgaggtgc ccttggagac cccgcatgtc     600

cacagccggg caccgtcccc actctacagc gtggagttct ccgaggagcc cttcggggtg     660

atcgtgcgcc ggcagctgga cggccgcgtg ctgctgaaca cgacggtggc gcccctgttc     720

tttgcggacc agttccttca gctgtccacc tcgctgccct cgcagtatat cacaggcctc     780

gccgagcacc tcagtcccct gatgctcagc accagctgga ccaggatcac cctgtggaac     840

cgggaccttg cgcccacgcc cggtgcgaac ctctacgggt ctcacccttt ctacctggcg     900

ctggaggacg gcgggtcggc acacggggtg ttcctgctaa acagcaatgc catggatgtg     960

gtcctgcagc cgagccctgc ccttagctgg aggtcgacag gtgggatcct ggatgtctac    1020

atcttcctgg gcccagagcc caagagcgtg gtgcagcagt acctggacgt tgtgggatac    1080

ccgttcatgc cgccatactg gggcctgggc ttccacctgt gccgctgggg ctactcctcc    1140

accgctatca cccgccaggt ggtggagaac atgaccaggg cccacttccc cctggacgtc    1200

cagtggaacg acctggacta catggactcc cggagggact tcacgttcaa caaggatggc    1260

ttccgggact tcccggccat ggtgcaggag ctgcaccagg gcggccggcg ctacatgatg    1320

atcgtggatc ctgccatcag cagctcgggc cctgccggga gctacaggcc ctacgacgag    1380

ggtctgcgga ggggggtttt catcaccaac gagaccggcc agccgctgat tgggaaggta    1440

tggcccgggt ccactgcctt ccccgacttc accaacccca cagccctggc ctggtgggag    1500

gacatggtgg ctgagttcca tgaccaggtg cccttcgacg gcatgtggat tgacatgaac    1560

gagccttcca acttcatcag gggctctgag gacggctgcc ccaacaatga gctggagaac    1620

ccaccctacg tgcctggggt ggttgggggg accctccagg cggccaccat ctgtgcctcc    1680

agccaccagt ttctctccac acactacaac ctgcacaacc tctacggcct gaccgaagcc    1740

atcgcctccc acagggcgct ggtgaaggct cgggggacac gcccatttgt gatctcccgc    1800

tcgacctttg ctggccacgg ccgatacgcc ggccactgga cgggggacgt gtggagctcc    1860

tgggagcagc tcgcctcctc cgtgccagaa atcctgcagt ttaacctgct gggggtgcct    1920

ctggtcgggg ccgacgtctg cggcttcctg ggcaacacct cagaggagct gtgtgtgcgc    1980

tggacccagc tgggggcctt ctaccccttc atgcggaacc acaacagcct gctcagtctg    2040

ccccaggagc cgtacagctt cagcgagccg gcccagcagg ccatgaggaa ggccctcacc    2100

ctgcgctacg cactcctccc ccacctctac acactgttcc accaggccca cgtcgcgggg    2160

gagaccgtgg cccggcccct cttcctggag ttccccaagg actctagcac ctggactgtg    2220

gaccaccagc tcctgtgggg ggaggccctg ctcatcaccc cagtgctcca ggccgggaag    2280

gccgaagtga ctggctactt ccccttgggc acatggtacg acctgcagac ggtgccagta    2340

gaggcccttg gcagcctccc acccccacct gcagctcccc gtgagccagc catccacagc    2400

gaggggcagt gggtgacgct gccggccccc ctggacacca tcaacgtcca cctccgggct    2460

gggtacatca tccccctgca gggccctggc ctcacaacca cagagtcccg ccagcagccc    2520

atggccctgg ctgtggccct gaccaagggt ggggaggccc gaggggagct gttctgggac    2580

gatggagaga gcctggaagt gctggagcga ggggcctaca cacaggtcat cttcctggcc    2640

aggaataaca cgatcgtgaa tgagctggta cgtgtgacca gtgagggagc tggcctgcag    2700

ctgcagaagg tgactgtcct gggcgtggcc acggcgcccc agcaggtcct ctccaacggt    2760

gtccctgtct ccaacttcac ctacagcccc gacaccaagg tcctggacat ctgtgtctcg    2820

ctgttgatgg gagagcagtt tctcgtcagc tggtgttag                           2859


<210> 9
<211> 2778
<212> DNA
<213> artificial


<220> 
<223> hGAAwt w/o sp

<400> 9
gggcacatcc tactccatga tttcctgctg gttccccgag agctgagtgg ctcctcccca      60

gtcctggagg agactcaccc agctcaccag cagggagcca gcagaccagg gccccgggat     120

gcccaggcac accccgggcg gccgcgagca gtgcccacac agtgcgacgt cccccccaac     180

agccgcttcg attgcgcccc tgacaaggcc atcacccagg aacagtgcga ggcccgcggc     240

tgttgctaca tccctgcaaa gcaggggctg cagggagccc agatggggca gccctggtgc     300

ttcttcccac ccagctaccc cagctacaag ctggagaacc tgagctcctc tgaaatgggc     360

tacacggcca ccctgacccg taccaccccc accttcttcc ccaaggacat cctgaccctg     420

cggctggacg tgatgatgga gactgagaac cgcctccact tcacgatcaa agatccagct     480

aacaggcgct acgaggtgcc cttggagacc ccgcatgtcc acagccgggc accgtcccca     540

ctctacagcg tggagttctc cgaggagccc ttcggggtga tcgtgcgccg gcagctggac     600

ggccgcgtgc tgctgaacac gacggtggcg cccctgttct ttgcggacca gttccttcag     660

ctgtccacct cgctgccctc gcagtatatc acaggcctcg ccgagcacct cagtcccctg     720

atgctcagca ccagctggac caggatcacc ctgtggaacc gggaccttgc gcccacgccc     780

ggtgcgaacc tctacgggtc tcaccctttc tacctggcgc tggaggacgg cgggtcggca     840

cacggggtgt tcctgctaaa cagcaatgcc atggatgtgg tcctgcagcc gagccctgcc     900

cttagctgga ggtcgacagg tgggatcctg gatgtctaca tcttcctggg cccagagccc     960

aagagcgtgg tgcagcagta cctggacgtt gtgggatacc cgttcatgcc gccatactgg    1020

ggcctgggct tccacctgtg ccgctggggc tactcctcca ccgctatcac ccgccaggtg    1080

gtggagaaca tgaccagggc ccacttcccc ctggacgtcc agtggaacga cctggactac    1140

atggactccc ggagggactt cacgttcaac aaggatggct tccgggactt cccggccatg    1200

gtgcaggagc tgcaccaggg cggccggcgc tacatgatga tcgtggatcc tgccatcagc    1260

agctcgggcc ctgccgggag ctacaggccc tacgacgagg gtctgcggag gggggttttc    1320

atcaccaacg agaccggcca gccgctgatt gggaaggtat ggcccgggtc cactgccttc    1380

cccgacttca ccaaccccac agccctggcc tggtgggagg acatggtggc tgagttccat    1440

gaccaggtgc ccttcgacgg catgtggatt gacatgaacg agccttccaa cttcatcagg    1500

ggctctgagg acggctgccc caacaatgag ctggagaacc caccctacgt gcctggggtg    1560

gttgggggga ccctccaggc ggccaccatc tgtgcctcca gccaccagtt tctctccaca    1620

cactacaacc tgcacaacct ctacggcctg accgaagcca tcgcctccca cagggcgctg    1680

gtgaaggctc gggggacacg cccatttgtg atctcccgct cgacctttgc tggccacggc    1740

cgatacgccg gccactggac gggggacgtg tggagctcct gggagcagct cgcctcctcc    1800

gtgccagaaa tcctgcagtt taacctgctg ggggtgcctc tggtcggggc cgacgtctgc    1860

ggcttcctgg gcaacacctc agaggagctg tgtgtgcgct ggacccagct gggggccttc    1920

taccccttca tgcggaacca caacagcctg ctcagtctgc cccaggagcc gtacagcttc    1980

agcgagccgg cccagcaggc catgaggaag gccctcaccc tgcgctacgc actcctcccc    2040

cacctctaca cactgttcca ccaggcccac gtcgcggggg agaccgtggc ccggcccctc    2100

ttcctggagt tccccaagga ctctagcacc tggactgtgg accaccagct cctgtggggg    2160

gaggccctgc tcatcacccc agtgctccag gccgggaagg ccgaagtgac tggctacttc    2220

cccttgggca catggtacga cctgcagacg gtgccagtag aggcccttgg cagcctccca    2280

cccccacctg cagctccccg tgagccagcc atccacagcg aggggcagtg ggtgacgctg    2340

ccggcccccc tggacaccat caacgtccac ctccgggctg ggtacatcat ccccctgcag    2400

ggccctggcc tcacaaccac agagtcccgc cagcagccca tggccctggc tgtggccctg    2460

accaagggtg gggaggcccg aggggagctg ttctgggacg atggagagag cctggaagtg    2520

ctggagcgag gggcctacac acaggtcatc ttcctggcca ggaataacac gatcgtgaat    2580

gagctggtac gtgtgaccag tgagggagct ggcctgcagc tgcagaaggt gactgtcctg    2640

ggcgtggcca cggcgcccca gcaggtcctc tccaacggtg tccctgtctc caacttcacc    2700

tacagccccg acaccaaggt cctggacatc tgtgtctcgc tgttgatggg agagcagttt    2760

ctcgtcagct ggtgttag                                                  2778


<210> 10
<211> 2778
<212> DNA
<213> artificial


<220> 
<223> hGAAco1 w/o sp

<400> 10
ggccatatcc tgctgcacga ctttctacta gtgcccagag agctgagcgg cagctctccc      60

gtgctggaag aaacacaccc tgcccatcag cagggcgcct ctagacctgg acctagagat     120

gcccaggccc accccggcag acctagagct gtgcctaccc agtgtgacgt gccccccaac     180

agcagattcg actgcgcccc tgacaaggcc atcacccagg aacagtgcga ggccagaggc     240

tgctgctaca tccctgccaa gcagggactg cagggcgctc agatgggaca gccctggtgc     300

ttcttcccac cctcctaccc cagctacaag ctggaaaacc tgagcagcag cgagatgggc     360

tacaccgcca ccctgaccag aaccaccccc acattcttcc caaaggacat cctgaccctg     420

cggctggacg tgatgatgga aaccgagaac cggctgcact tcaccatcaa ggaccccgcc     480

aatcggagat acgaggtgcc cctggaaacc ccccacgtgc actctagagc ccccagccct     540

ctgtacagcg tggaattcag cgaggaaccc ttcggcgtga tcgtgcggag acagctggat     600

ggcagagtgc tgctgaacac caccgtggcc cctctgttct tcgccgacca gttcctgcag     660

ctgagcacca gcctgcccag ccagtacatc acaggactgg ccgagcacct gagccccctg     720

atgctgagca catcctggac ccggatcacc ctgtggaaca gggatctggc ccctacccct     780

ggcgccaatc tgtacggcag ccaccctttc tacctggccc tggaagatgg cggatctgcc     840

cacggagtgt ttctgctgaa ctccaacgcc atggacgtgg tgctgcagcc tagccctgcc     900

ctgtcttgga gaagcacagg cggcatcctg gatgtgtaca tctttctggg ccccgagccc     960

aagagcgtgg tgcagcagta tctggatgtc gtgggctacc ccttcatgcc cccttactgg    1020

ggcctgggat tccacctgtg cagatggggc tactccagca ccgccatcac cagacaggtg    1080

gtggaaaaca tgaccagagc ccacttccca ctggatgtgc agtggaacga cctggactac    1140

atggacagca gacgggactt caccttcaac aaggacggct tccgggactt ccccgccatg    1200

gtgcaggaac tgcatcaggg cggcagacgg tacatgatga tcgtggatcc cgccatcagc    1260

tcctctggcc ctgccggctc ttacagaccc tacgacgagg gcctgcggag aggcgtgttc    1320

atcaccaacg agacaggcca gcccctgatc ggcaaagtgt ggcctggcag cacagccttc    1380

cccgacttca ccaatcctac cgccctggct tggtgggagg acatggtggc cgagttccac    1440

gaccaggtgc ccttcgacgg catgtggatc gacatgaacg agcccagcaa cttcatccgg    1500

ggcagcgagg atggctgccc caacaacgaa ctggaaaatc ccccttacgt gcccggcgtc    1560

gtgggcggaa cactgcaggc cgctacaatc tgtgccagca gccaccagtt tctgagcacc    1620

cactacaacc tgcacaacct gtacggcctg accgaggcca ttgccagcca ccgcgctctc    1680

gtgaaagcca gaggcacacg gcccttcgtg atcagcagaa gcacctttgc cggccacggc    1740

agatacgccg gacattggac tggcgacgtg tggtcctctt gggagcagct ggcctctagc    1800

gtgcccgaga tcctgcagtt caatctgctg ggcgtgccac tcgtgggcgc cgatgtgtgt    1860

ggcttcctgg gcaacacctc cgaggaactg tgtgtgcggt ggacacagct gggcgccttc    1920

taccctttca tgagaaacca caacagcctg ctgagcctgc cccaggaacc ctacagcttt    1980

agcgagcctg cacagcaggc catgcggaag gccctgacac tgagatacgc tctgctgccc    2040

cacctgtaca ccctgtttca ccaggcccat gtggccggcg agacagtggc cagacctctg    2100

tttctggaat tccccaagga cagcagcacc tggaccgtgg accatcagct gctgtgggga    2160

gaggctctgc tgattacccc agtgctgcag gcaggcaagg ccgaagtgac cggctacttt    2220

cccctgggca cttggtacga cctgcagacc gtgcctgtgg aagccctggg atctctgcct    2280

ccacctcctg ccgctcctag agagcctgcc attcactctg agggccagtg ggtcacactg    2340

cctgcccccc tggataccat caacgtgcac ctgagggccg gctacatcat accactgcag    2400

ggacctggcc tgaccaccac cgagtctaga cagcagccaa tggccctggc cgtggccctg    2460

accaaaggcg gagaagctag gggcgagctg ttctgggacg atggcgagag cctggaagtg    2520

ctggaaagag gcgcctatac ccaagtgatc ttcctggccc ggaacaacac catcgtgaac    2580

gagctggtgc gcgtgacctc tgaaggcgct ggactgcagc tgcagaaagt gaccgtgctg    2640

ggagtggcca cagcccctca gcaggtgctg tctaatggcg tgcccgtgtc caacttcacc    2700

tacagccccg acaccaaggt gctggacatc tgcgtgtcac tgctgatggg agagcagttt    2760

ctggtgtcct ggtgctga                                                  2778


<210> 11
<211> 2778
<212> DNA
<213> artificial


<220> 
<223> hGAAco2 w/o sp

<400> 11
ggacacatcc tgctgcacga cttcctgttg gtgcctagag agctgagcgg atcatcccca      60

gtgctggagg agactcatcc tgctcaccaa cagggagctt ccagaccagg accgagagac     120

gcccaagccc atcctggtag accaagagct gtgcctaccc aatgcgacgt gccacccaac     180

tcccgattcg actgcgcgcc agataaggct attacccaag agcagtgtga agccagaggt     240

tgctgctaca tcccagcgaa gcaaggattg caaggcgccc aaatgggaca accttggtgt     300

ttcttccccc cttcgtaccc atcatataaa ctcgaaaacc tgtcctcttc ggaaatgggt     360

tatactgcca ccctcaccag aactactcct actttcttcc cgaaagacat cttgaccttg     420

aggctggacg tgatgatgga gactgaaaac cggctgcatt tcactatcaa agatcctgcc     480

aatcggcgat acgaggtccc tctggaaacc cctcacgtgc actcacgggc tccttctccg     540

ctttactccg tcgaattctc tgaggaaccc ttcggagtga tcgttagacg ccagctggat     600

ggtagagtgc tgttgaacac tactgtggcc ccacttttct tcgctgacca gtttctgcaa     660

ctgtccactt ccctgccatc ccagtacatt actggactcg ccgaacacct gtcgccactg     720

atgctctcga cctcttggac tagaatcact ttgtggaaca gagacttggc ccctactccg     780

ggagcaaatc tgtacggaag ccaccctttt tacctggcgc tcgaagatgg cggatccgct     840

cacggagtgt tcctgctgaa tagcaacgca atggacgtgg tgctgcaacc ttcccctgca     900

ctcagttgga gaagtaccgg gggtattctg gacgtgtaca tcttcctcgg accagaaccc     960

aagagcgtgg tgcagcaata tctggacgtg gtcggatacc cttttatgcc tccttactgg    1020

ggactgggat tccacctttg ccgttggggc tactcatcca ccgccattac cagacaggtg    1080

gtggagaata tgaccagagc ccacttccct ctcgacgtgc agtggaacga tctggactat    1140

atggactccc ggagagattt caccttcaac aaggacgggt tccgcgattt tcccgcgatg    1200

gttcaagagc tccaccaggg tggtcgaaga tatatgatga tcgtcgaccc agccatttcg    1260

agcagcggac ccgctggatc ttatagacct tacgacgaag gccttaggag aggagtgttc    1320

atcacaaacg agactggaca gcctttgatc ggtaaagtgt ggcctggatc aaccgccttt    1380

cctgacttta ccaatcccac tgccttggct tggtgggagg acatggtggc cgaattccac    1440

gaccaagtcc cctttgatgg aatgtggatc gatatgaacg aaccaagcaa ttttatcaga    1500

ggttccgaag acggttgccc caacaacgaa ctggaaaacc ctccttatgt gcccggagtc    1560

gtgggcggaa cattacaggc cgcgactatt tgcgccagca gccaccaatt cctgtccact    1620

cactacaacc tccacaacct ttatggatta accgaagcta ttgcaagtca cagggctctg    1680

gtgaaggcta gagggactag gccctttgtg atctcccgat ccacctttgc cggacacggg    1740

agatacgccg gtcactggac tggtgacgtg tggagctcat gggaacaact ggcctcctcc    1800

gtgccggaaa tcttacagtt caaccttctg ggtgtccctc ttgtcggagc agacgtgtgt    1860

gggtttcttg gtaacacctc cgaggaactg tgtgtgcgct ggactcaact gggtgcattc    1920

tacccattca tgagaaacca caactccttg ctgtccctgc cacaagagcc ctactcgttc    1980

agcgagcctg cacaacaggc tatgcggaag gcactgaccc tgagatacgc cctgcttcca    2040

cacttataca ctctcttcca tcaagcgcat gtggcaggag aaaccgttgc aaggcctctt    2100

ttccttgaat tccccaagga ttcctcgact tggacggtgg atcatcagct gctgtgggga    2160

gaagctctgc tgattactcc agtgttgcaa gccggaaaag ctgaggtgac cggatacttt    2220

ccgctgggaa cctggtacga cctccagact gtccctgttg aagcccttgg atcactgcct    2280

ccgcctccgg cagctccacg cgaaccagct atacattccg agggacagtg ggttacatta    2340

ccagctcctc tggacacaat caacgtccac ttaagagctg gctacattat ccctctgcaa    2400

ggaccaggac tgactacgac cgagagcaga cagcagccaa tggcactggc tgtggctctg    2460

accaagggag gggaagctag aggagaactc ttctgggatg atggggagtc ccttgaagtg    2520

ctggaaagag gcgcttacac tcaagtcatt ttccttgcac ggaacaacac cattgtgaac    2580

gaattggtgc gagtgaccag cgaaggagct ggacttcaac tgcagaaggt cactgtgctc    2640

ggagtggcta ccgctcctca gcaagtgctg tcgaatggag tccccgtgtc aaactttacc    2700

tactcccctg acactaaggt gctcgacatt tgcgtgtccc tcctgatggg agagcagttc    2760

cttgtgtcct ggtgttga                                                  2778


<210> 12
<211> 2754
<212> DNA
<213> artificial


<220> 
<223> hGAAco1-delta-8 w/o sp

<400> 12
ctactagtgc ccagagagct gagcggcagc tctcccgtgc tggaagaaac acaccctgcc      60

catcagcagg gcgcctctag acctggacct agagatgccc aggcccaccc cggcagacct     120

agagctgtgc ctacccagtg tgacgtgccc cccaacagca gattcgactg cgcccctgac     180

aaggccatca cccaggaaca gtgcgaggcc agaggctgct gctacatccc tgccaagcag     240

ggactgcagg gcgctcagat gggacagccc tggtgcttct tcccaccctc ctaccccagc     300

tacaagctgg aaaacctgag cagcagcgag atgggctaca ccgccaccct gaccagaacc     360

acccccacat tcttcccaaa ggacatcctg accctgcggc tggacgtgat gatggaaacc     420

gagaaccggc tgcacttcac catcaaggac cccgccaatc ggagatacga ggtgcccctg     480

gaaacccccc acgtgcactc tagagccccc agccctctgt acagcgtgga attcagcgag     540

gaacccttcg gcgtgatcgt gcggagacag ctggatggca gagtgctgct gaacaccacc     600

gtggcccctc tgttcttcgc cgaccagttc ctgcagctga gcaccagcct gcccagccag     660

tacatcacag gactggccga gcacctgagc cccctgatgc tgagcacatc ctggacccgg     720

atcaccctgt ggaacaggga tctggcccct acccctggcg ccaatctgta cggcagccac     780

cctttctacc tggccctgga agatggcgga tctgcccacg gagtgtttct gctgaactcc     840

aacgccatgg acgtggtgct gcagcctagc cctgccctgt cttggagaag cacaggcggc     900

atcctggatg tgtacatctt tctgggcccc gagcccaaga gcgtggtgca gcagtatctg     960

gatgtcgtgg gctacccctt catgccccct tactggggcc tgggattcca cctgtgcaga    1020

tggggctact ccagcaccgc catcaccaga caggtggtgg aaaacatgac cagagcccac    1080

ttcccactgg atgtgcagtg gaacgacctg gactacatgg acagcagacg ggacttcacc    1140

ttcaacaagg acggcttccg ggacttcccc gccatggtgc aggaactgca tcagggcggc    1200

agacggtaca tgatgatcgt ggatcccgcc atcagctcct ctggccctgc cggctcttac    1260

agaccctacg acgagggcct gcggagaggc gtgttcatca ccaacgagac aggccagccc    1320

ctgatcggca aagtgtggcc tggcagcaca gccttccccg acttcaccaa tcctaccgcc    1380

ctggcttggt gggaggacat ggtggccgag ttccacgacc aggtgccctt cgacggcatg    1440

tggatcgaca tgaacgagcc cagcaacttc atccggggca gcgaggatgg ctgccccaac    1500

aacgaactgg aaaatccccc ttacgtgccc ggcgtcgtgg gcggaacact gcaggccgct    1560

acaatctgtg ccagcagcca ccagtttctg agcacccact acaacctgca caacctgtac    1620

ggcctgaccg aggccattgc cagccaccgc gctctcgtga aagccagagg cacacggccc    1680

ttcgtgatca gcagaagcac ctttgccggc cacggcagat acgccggaca ttggactggc    1740

gacgtgtggt cctcttggga gcagctggcc tctagcgtgc ccgagatcct gcagttcaat    1800

ctgctgggcg tgccactcgt gggcgccgat gtgtgtggct tcctgggcaa cacctccgag    1860

gaactgtgtg tgcggtggac acagctgggc gccttctacc ctttcatgag aaaccacaac    1920

agcctgctga gcctgcccca ggaaccctac agctttagcg agcctgcaca gcaggccatg    1980

cggaaggccc tgacactgag atacgctctg ctgccccacc tgtacaccct gtttcaccag    2040

gcccatgtgg ccggcgagac agtggccaga cctctgtttc tggaattccc caaggacagc    2100

agcacctgga ccgtggacca tcagctgctg tggggagagg ctctgctgat taccccagtg    2160

ctgcaggcag gcaaggccga agtgaccggc tactttcccc tgggcacttg gtacgacctg    2220

cagaccgtgc ctgtggaagc cctgggatct ctgcctccac ctcctgccgc tcctagagag    2280

cctgccattc actctgaggg ccagtgggtc acactgcctg cccccctgga taccatcaac    2340

gtgcacctga gggccggcta catcatacca ctgcagggac ctggcctgac caccaccgag    2400

tctagacagc agccaatggc cctggccgtg gccctgacca aaggcggaga agctaggggc    2460

gagctgttct gggacgatgg cgagagcctg gaagtgctgg aaagaggcgc ctatacccaa    2520

gtgatcttcc tggcccggaa caacaccatc gtgaacgagc tggtgcgcgt gacctctgaa    2580

ggcgctggac tgcagctgca gaaagtgacc gtgctgggag tggccacagc ccctcagcag    2640

gtgctgtcta atggcgtgcc cgtgtccaac ttcacctaca gccccgacac caaggtgctg    2700

gacatctgcg tgtcactgct gatgggagag cagtttctgg tgtcctggtg ctga          2754


<210> 13
<211> 2754
<212> DNA
<213> artificial


<220> 
<223> hGAAco2-delta8 w/o sp

<400> 13
ctgttggtgc ctagagagct gagcggatca tccccagtgc tggaggagac tcatcctgct      60

caccaacagg gagcttccag accaggaccg agagacgccc aagcccatcc tggtagacca     120

agagctgtgc ctacccaatg cgacgtgcca cccaactccc gattcgactg cgcgccagat     180

aaggctatta cccaagagca gtgtgaagcc agaggttgct gctacatccc agcgaagcaa     240

ggattgcaag gcgcccaaat gggacaacct tggtgtttct tccccccttc gtacccatca     300

tataaactcg aaaacctgtc ctcttcggaa atgggttata ctgccaccct caccagaact     360

actcctactt tcttcccgaa agacatcttg accttgaggc tggacgtgat gatggagact     420

gaaaaccggc tgcatttcac tatcaaagat cctgccaatc ggcgatacga ggtccctctg     480

gaaacccctc acgtgcactc acgggctcct tctccgcttt actccgtcga attctctgag     540

gaacccttcg gagtgatcgt tagacgccag ctggatggta gagtgctgtt gaacactact     600

gtggccccac ttttcttcgc tgaccagttt ctgcaactgt ccacttccct gccatcccag     660

tacattactg gactcgccga acacctgtcg ccactgatgc tctcgacctc ttggactaga     720

atcactttgt ggaacagaga cttggcccct actccgggag caaatctgta cggaagccac     780

cctttttacc tggcgctcga agatggcgga tccgctcacg gagtgttcct gctgaatagc     840

aacgcaatgg acgtggtgct gcaaccttcc cctgcactca gttggagaag taccgggggt     900

attctggacg tgtacatctt cctcggacca gaacccaaga gcgtggtgca gcaatatctg     960

gacgtggtcg gatacccttt tatgcctcct tactggggac tgggattcca cctttgccgt    1020

tggggctact catccaccgc cattaccaga caggtggtgg agaatatgac cagagcccac    1080

ttccctctcg acgtgcagtg gaacgatctg gactatatgg actcccggag agatttcacc    1140

ttcaacaagg acgggttccg cgattttccc gcgatggttc aagagctcca ccagggtggt    1200

cgaagatata tgatgatcgt cgacccagcc atttcgagca gcggacccgc tggatcttat    1260

agaccttacg acgaaggcct taggagagga gtgttcatca caaacgagac tggacagcct    1320

ttgatcggta aagtgtggcc tggatcaacc gcctttcctg actttaccaa tcccactgcc    1380

ttggcttggt gggaggacat ggtggccgaa ttccacgacc aagtcccctt tgatggaatg    1440

tggatcgata tgaacgaacc aagcaatttt atcagaggtt ccgaagacgg ttgccccaac    1500

aacgaactgg aaaaccctcc ttatgtgccc ggagtcgtgg gcggaacatt acaggccgcg    1560

actatttgcg ccagcagcca ccaattcctg tccactcact acaacctcca caacctttat    1620

ggattaaccg aagctattgc aagtcacagg gctctggtga aggctagagg gactaggccc    1680

tttgtgatct cccgatccac ctttgccgga cacgggagat acgccggtca ctggactggt    1740

gacgtgtgga gctcatggga acaactggcc tcctccgtgc cggaaatctt acagttcaac    1800

cttctgggtg tccctcttgt cggagcagac gtgtgtgggt ttcttggtaa cacctccgag    1860

gaactgtgtg tgcgctggac tcaactgggt gcattctacc cattcatgag aaaccacaac    1920

tccttgctgt ccctgccaca agagccctac tcgttcagcg agcctgcaca acaggctatg    1980

cggaaggcac tgaccctgag atacgccctg cttccacact tatacactct cttccatcaa    2040

gcgcatgtgg caggagaaac cgttgcaagg cctcttttcc ttgaattccc caaggattcc    2100

tcgacttgga cggtggatca tcagctgctg tggggagaag ctctgctgat tactccagtg    2160

ttgcaagccg gaaaagctga ggtgaccgga tactttccgc tgggaacctg gtacgacctc    2220

cagactgtcc ctgttgaagc ccttggatca ctgcctccgc ctccggcagc tccacgcgaa    2280

ccagctatac attccgaggg acagtgggtt acattaccag ctcctctgga cacaatcaac    2340

gtccacttaa gagctggcta cattatccct ctgcaaggac caggactgac tacgaccgag    2400

agcagacagc agccaatggc actggctgtg gctctgacca agggagggga agctagagga    2460

gaactcttct gggatgatgg ggagtccctt gaagtgctgg aaagaggcgc ttacactcaa    2520

gtcattttcc ttgcacggaa caacaccatt gtgaacgaat tggtgcgagt gaccagcgaa    2580

ggagctggac ttcaactgca gaaggtcact gtgctcggag tggctaccgc tcctcagcaa    2640

gtgctgtcga atggagtccc cgtgtcaaac tttacctact cccctgacac taaggtgctc    2700

gacatttgcg tgtccctcct gatgggagag cagttccttg tgtcctggtg ttga          2754


<210> 14
<211> 397
<212> DNA
<213> artificial


<220> 
<223> hAAT promoter

<400> 14
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta      60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac     120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca     180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact     240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct     300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct     360

cagcttcagg caccaccact gacctgggac agtgaat                              397


<210> 15
<211> 321
<212> DNA
<213> artificial


<220> 
<223> ApoE control region

<400> 15
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc      60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc     120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc     180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc     240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt     300

ggtttaggta gtgtgagagg g                                               321


<210> 16
<211> 441
<212> DNA
<213> artificial


<220> 
<223> HBB2 intron

<400> 16
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt      60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca     120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata     180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt     240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt     300

ttattttatg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa     360

tcatgttcat acctcttatc ttcctcccac agctcctggg caacgtgctg gtctgtgtgc     420

tggcccatca ctttggcaaa g                                               441


<210> 17
<211> 441
<212> DNA
<213> artificial


<220> 
<223> modified HBB2 intron

<400> 17
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt      60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca     120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata     180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt     240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt     300

ttattttctg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa     360

tcttgttcat acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc     420

tggcccatca ctttggcaaa g                                               441


<210> 18
<211> 1438
<212> DNA
<213> artificial


<220> 
<223> FIX intron

<400> 18
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct      60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta     120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc     180

atttttaaaa ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt     240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa     300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta     360

tttttgtttg gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc     420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt     480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa     540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta     600

ggaaaaaatc attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa     660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga     720

agttagctaa tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt     780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac     840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt     900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc     960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt    1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc    1080

agggtgatgg atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg    1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt    1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt    1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct    1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta    1380

aaattttcat gatgttttct tttttgctaa aactaaagaa ttattctttt acatttca      1438


<210> 19
<211> 1438
<212> DNA
<213> artificial


<220> 
<223> modified FIX intron

<400> 19
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct      60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta     120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc     180

atttttaaaa ctaaatagat cgacattgct tttgttgcat ttatgtttaa taaacactgt     240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa     300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta     360

tttttgtttg gacttaccac tttgaaatca aattgggaaa caaaagcaca aacaatggcc     420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt     480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa     540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta     600

ggaaaaaatc attttgtctc tttgtcaaac atcttggagt tgatatttgg ggaaacacaa     660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga     720

agttagctat tgcaacatat atcactttgt tttttcacaa ctacagtgac tttttgtatt     780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc ttgttctcac     840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt     900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc     960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt    1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc    1080

agggtgttgg atcactttgc aaagatcctc attgagctat tttcaagtgt tgacaaagtg    1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt    1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt    1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct    1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta    1380

aaattttctt gttgttttct tttttgctaa aactaaagaa ttattctttt acatttca      1438


<210> 20
<211> 881
<212> DNA
<213> artificial


<220> 
<223> chicken beta-globin intron

<400> 20
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc     120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga     180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg     240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg     300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg     360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca     480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg     540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc     600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg     660

cggctgtcga ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc     720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac     780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga     840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                         881


<210> 21
<211> 881
<212> DNA
<213> artificial


<220> 
<223> modified chicken beta-globin intron

<400> 21
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc      60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc     120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga     180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg     240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg     300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg     360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt     420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca     480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg     540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc     600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg     660

cggctgtcga ggcgcggcga gccgcagcca ttgccttttt tggtaatcgt gcgagagggc     720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac     780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaat tgggcgggga     840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                         881


<210> 22
<211> 4318
<212> DNA
<213> artificial


<220> 
<223> construct: sp2+hGAAwt-delta-8

<400> 22
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc      780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat      840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat      900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat      960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt     1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta     1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg     1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat     1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca     1260

ctttggcaaa gcacgcgtgc caccatgccg tcttctgtct cgtggggcat cctcctgctg     1320

gcaggcctgt gctgcctggt ccctgtctcc ctggctctgc tggttccccg agagctgagt     1380

ggctcctccc cagtcctgga ggagactcac ccagctcacc agcagggagc cagcagacca     1440

gggccccggg atgcccaggc acaccccggg cggccgcgag cagtgcccac acagtgcgac     1500

gtccccccca acagccgctt cgattgcgcc cctgacaagg ccatcaccca ggaacagtgc     1560

gaggcccgcg gctgttgcta catccctgca aagcaggggc tgcagggagc ccagatgggg     1620

cagccctggt gcttcttccc acccagctac cccagctaca agctggagaa cctgagctcc     1680

tctgaaatgg gctacacggc caccctgacc cgtaccaccc ccaccttctt ccccaaggac     1740

atcctgaccc tgcggctgga cgtgatgatg gagactgaga accgcctcca cttcacgatc     1800

aaagatccag ctaacaggcg ctacgaggtg cccttggaga ccccgcatgt ccacagccgg     1860

gcaccgtccc cactctacag cgtggagttc tccgaggagc ccttcggggt gatcgtgcgc     1920

cggcagctgg acggccgcgt gctgctgaac acgacggtgg cgcccctgtt ctttgcggac     1980

cagttccttc agctgtccac ctcgctgccc tcgcagtata tcacaggcct cgccgagcac     2040

ctcagtcccc tgatgctcag caccagctgg accaggatca ccctgtggaa ccgggacctt     2100

gcgcccacgc ccggtgcgaa cctctacggg tctcaccctt tctacctggc gctggaggac     2160

ggcgggtcgg cacacggggt gttcctgcta aacagcaatg ccatggatgt ggtcctgcag     2220

ccgagccctg cccttagctg gaggtcgaca ggtgggatcc tggatgtcta catcttcctg     2280

ggcccagagc ccaagagcgt ggtgcagcag tacctggacg ttgtgggata cccgttcatg     2340

ccgccatact ggggcctggg cttccacctg tgccgctggg gctactcctc caccgctatc     2400

acccgccagg tggtggagaa catgaccagg gcccacttcc ccctggacgt ccagtggaac     2460

gacctggact acatggactc ccggagggac ttcacgttca acaaggatgg cttccgggac     2520

ttcccggcca tggtgcagga gctgcaccag ggcggccggc gctacatgat gatcgtggat     2580

cctgccatca gcagctcggg ccctgccggg agctacaggc cctacgacga gggtctgcgg     2640

aggggggttt tcatcaccaa cgagaccggc cagccgctga ttgggaaggt atggcccggg     2700

tccactgcct tccccgactt caccaacccc acagccctgg cctggtggga ggacatggtg     2760

gctgagttcc atgaccaggt gcccttcgac ggcatgtgga ttgacatgaa cgagccttcc     2820

aacttcatca ggggctctga ggacggctgc cccaacaatg agctggagaa cccaccctac     2880

gtgcctgggg tggttggggg gaccctccag gcggccacca tctgtgcctc cagccaccag     2940

tttctctcca cacactacaa cctgcacaac ctctacggcc tgaccgaagc catcgcctcc     3000

cacagggcgc tggtgaaggc tcgggggaca cgcccatttg tgatctcccg ctcgaccttt     3060

gctggccacg gccgatacgc cggccactgg acgggggacg tgtggagctc ctgggagcag     3120

ctcgcctcct ccgtgccaga aatcctgcag tttaacctgc tgggggtgcc tctggtcggg     3180

gccgacgtct gcggcttcct gggcaacacc tcagaggagc tgtgtgtgcg ctggacccag     3240

ctgggggcct tctacccctt catgcggaac cacaacagcc tgctcagtct gccccaggag     3300

ccgtacagct tcagcgagcc ggcccagcag gccatgagga aggccctcac cctgcgctac     3360

gcactcctcc cccacctcta cacactgttc caccaggccc acgtcgcggg ggagaccgtg     3420

gcccggcccc tcttcctgga gttccccaag gactctagca cctggactgt ggaccaccag     3480

ctcctgtggg gggaggccct gctcatcacc ccagtgctcc aggccgggaa ggccgaagtg     3540

actggctact tccccttggg cacatggtac gacctgcaga cggtgccagt agaggccctt     3600

ggcagcctcc cacccccacc tgcagctccc cgtgagccag ccatccacag cgaggggcag     3660

tgggtgacgc tgccggcccc cctggacacc atcaacgtcc acctccgggc tgggtacatc     3720

atccccctgc agggccctgg cctcacaacc acagagtccc gccagcagcc catggccctg     3780

gctgtggccc tgaccaaggg tggggaggcc cgaggggagc tgttctggga cgatggagag     3840

agcctggaag tgctggagcg aggggcctac acacaggtca tcttcctggc caggaataac     3900

acgatcgtga atgagctggt acgtgtgacc agtgagggag ctggcctgca gctgcagaag     3960

gtgactgtcc tgggcgtggc cacggcgccc cagcaggtcc tctccaacgg tgtccctgtc     4020

tccaacttca cctacagccc cgacaccaag gtcctggaca tctgtgtctc gctgttgatg     4080

ggagagcagt ttctcgtcag ctggtgttag ctcgagagat ctaccggtga attcaccgcg     4140

ggtttaaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     4200

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     4260

gcattgtctg agtaggtgtc attctattct ggggggtggg gtgggggcta gctctaga       4318


<210> 23
<211> 4318
<212> DNA
<213> artificial


<220> 
<223> construct: sp2+hGAAco1-delta-8

<400> 23
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc      780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat      840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat      900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat      960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt     1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta     1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg     1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat     1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca     1260

ctttggcaaa gcacgcgtgc caccatgcct agctctgtgt cctggggcat tctgctgctg     1320

gccggcctgt gttgtctggt gcctgtgtct ctggccctac tagtgcccag agagctgagc     1380

ggcagctctc ccgtgctgga agaaacacac cctgcccatc agcagggcgc ctctagacct     1440

ggacctagag atgcccaggc ccaccccggc agacctagag ctgtgcctac ccagtgtgac     1500

gtgcccccca acagcagatt cgactgcgcc cctgacaagg ccatcaccca ggaacagtgc     1560

gaggccagag gctgctgcta catccctgcc aagcagggac tgcagggcgc tcagatggga     1620

cagccctggt gcttcttccc accctcctac cccagctaca agctggaaaa cctgagcagc     1680

agcgagatgg gctacaccgc caccctgacc agaaccaccc ccacattctt cccaaaggac     1740

atcctgaccc tgcggctgga cgtgatgatg gaaaccgaga accggctgca cttcaccatc     1800

aaggaccccg ccaatcggag atacgaggtg cccctggaaa ccccccacgt gcactctaga     1860

gcccccagcc ctctgtacag cgtggaattc agcgaggaac ccttcggcgt gatcgtgcgg     1920

agacagctgg atggcagagt gctgctgaac accaccgtgg cccctctgtt cttcgccgac     1980

cagttcctgc agctgagcac cagcctgccc agccagtaca tcacaggact ggccgagcac     2040

ctgagccccc tgatgctgag cacatcctgg acccggatca ccctgtggaa cagggatctg     2100

gcccctaccc ctggcgccaa tctgtacggc agccaccctt tctacctggc cctggaagat     2160

ggcggatctg cccacggagt gtttctgctg aactccaacg ccatggacgt ggtgctgcag     2220

cctagccctg ccctgtcttg gagaagcaca ggcggcatcc tggatgtgta catctttctg     2280

ggccccgagc ccaagagcgt ggtgcagcag tatctggatg tcgtgggcta ccccttcatg     2340

cccccttact ggggcctggg attccacctg tgcagatggg gctactccag caccgccatc     2400

accagacagg tggtggaaaa catgaccaga gcccacttcc cactggatgt gcagtggaac     2460

gacctggact acatggacag cagacgggac ttcaccttca acaaggacgg cttccgggac     2520

ttccccgcca tggtgcagga actgcatcag ggcggcagac ggtacatgat gatcgtggat     2580

cccgccatca gctcctctgg ccctgccggc tcttacagac cctacgacga gggcctgcgg     2640

agaggcgtgt tcatcaccaa cgagacaggc cagcccctga tcggcaaagt gtggcctggc     2700

agcacagcct tccccgactt caccaatcct accgccctgg cttggtggga ggacatggtg     2760

gccgagttcc acgaccaggt gcccttcgac ggcatgtgga tcgacatgaa cgagcccagc     2820

aacttcatcc ggggcagcga ggatggctgc cccaacaacg aactggaaaa tcccccttac     2880

gtgcccggcg tcgtgggcgg aacactgcag gccgctacaa tctgtgccag cagccaccag     2940

tttctgagca cccactacaa cctgcacaac ctgtacggcc tgaccgaggc cattgccagc     3000

caccgcgctc tcgtgaaagc cagaggcaca cggcccttcg tgatcagcag aagcaccttt     3060

gccggccacg gcagatacgc cggacattgg actggcgacg tgtggtcctc ttgggagcag     3120

ctggcctcta gcgtgcccga gatcctgcag ttcaatctgc tgggcgtgcc actcgtgggc     3180

gccgatgtgt gtggcttcct gggcaacacc tccgaggaac tgtgtgtgcg gtggacacag     3240

ctgggcgcct tctacccttt catgagaaac cacaacagcc tgctgagcct gccccaggaa     3300

ccctacagct ttagcgagcc tgcacagcag gccatgcgga aggccctgac actgagatac     3360

gctctgctgc cccacctgta caccctgttt caccaggccc atgtggccgg cgagacagtg     3420

gccagacctc tgtttctgga attccccaag gacagcagca cctggaccgt ggaccatcag     3480

ctgctgtggg gagaggctct gctgattacc ccagtgctgc aggcaggcaa ggccgaagtg     3540

accggctact ttcccctggg cacttggtac gacctgcaga ccgtgcctgt ggaagccctg     3600

ggatctctgc ctccacctcc tgccgctcct agagagcctg ccattcactc tgagggccag     3660

tgggtcacac tgcctgcccc cctggatacc atcaacgtgc acctgagggc cggctacatc     3720

ataccactgc agggacctgg cctgaccacc accgagtcta gacagcagcc aatggccctg     3780

gccgtggccc tgaccaaagg cggagaagct aggggcgagc tgttctggga cgatggcgag     3840

agcctggaag tgctggaaag aggcgcctat acccaagtga tcttcctggc ccggaacaac     3900

accatcgtga acgagctggt gcgcgtgacc tctgaaggcg ctggactgca gctgcagaaa     3960

gtgaccgtgc tgggagtggc cacagcccct cagcaggtgc tgtctaatgg cgtgcccgtg     4020

tccaacttca cctacagccc cgacaccaag gtgctggaca tctgcgtgtc actgctgatg     4080

ggagagcagt ttctggtgtc ctggtgctga ctcgagagat ctaccggtga attcaccgcg     4140

ggtttaaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     4200

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     4260

gcattgtctg agtaggtgtc attctattct ggggggtggg gtgggggcta gctctaga       4318


<210> 24
<211> 4318
<212> DNA
<213> artificial


<220> 
<223> construct: sp2+hGAAco2-delta-8

<400> 24
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc      780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat      840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat      900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat      960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt     1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta     1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg     1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat     1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca     1260

ctttggcaaa gcacgcgtgc caccatgcca tcgtcagtgt cttggggcat tcttctgctc     1320

gccggattgt gttgcctggt gcctgtctca ttggccctgt tggtgcctag agagctgagc     1380

ggatcatccc cagtgctgga ggagactcat cctgctcacc aacagggagc ttccagacca     1440

ggaccgagag acgcccaagc ccatcctggt agaccaagag ctgtgcctac ccaatgcgac     1500

gtgccaccca actcccgatt cgactgcgcg ccagataagg ctattaccca agagcagtgt     1560

gaagccagag gttgctgcta catcccagcg aagcaaggat tgcaaggcgc ccaaatggga     1620

caaccttggt gtttcttccc cccttcgtac ccatcatata aactcgaaaa cctgtcctct     1680

tcggaaatgg gttatactgc caccctcacc agaactactc ctactttctt cccgaaagac     1740

atcttgacct tgaggctgga cgtgatgatg gagactgaaa accggctgca tttcactatc     1800

aaagatcctg ccaatcggcg atacgaggtc cctctggaaa cccctcacgt gcactcacgg     1860

gctccttctc cgctttactc cgtcgaattc tctgaggaac ccttcggagt gatcgttaga     1920

cgccagctgg atggtagagt gctgttgaac actactgtgg ccccactttt cttcgctgac     1980

cagtttctgc aactgtccac ttccctgcca tcccagtaca ttactggact cgccgaacac     2040

ctgtcgccac tgatgctctc gacctcttgg actagaatca ctttgtggaa cagagacttg     2100

gcccctactc cgggagcaaa tctgtacgga agccaccctt tttacctggc gctcgaagat     2160

ggcggatccg ctcacggagt gttcctgctg aatagcaacg caatggacgt ggtgctgcaa     2220

ccttcccctg cactcagttg gagaagtacc gggggtattc tggacgtgta catcttcctc     2280

ggaccagaac ccaagagcgt ggtgcagcaa tatctggacg tggtcggata cccttttatg     2340

cctccttact ggggactggg attccacctt tgccgttggg gctactcatc caccgccatt     2400

accagacagg tggtggagaa tatgaccaga gcccacttcc ctctcgacgt gcagtggaac     2460

gatctggact atatggactc ccggagagat ttcaccttca acaaggacgg gttccgcgat     2520

tttcccgcga tggttcaaga gctccaccag ggtggtcgaa gatatatgat gatcgtcgac     2580

ccagccattt cgagcagcgg acccgctgga tcttatagac cttacgacga aggccttagg     2640

agaggagtgt tcatcacaaa cgagactgga cagcctttga tcggtaaagt gtggcctgga     2700

tcaaccgcct ttcctgactt taccaatccc actgccttgg cttggtggga ggacatggtg     2760

gccgaattcc acgaccaagt cccctttgat ggaatgtgga tcgatatgaa cgaaccaagc     2820

aattttatca gaggttccga agacggttgc cccaacaacg aactggaaaa ccctccttat     2880

gtgcccggag tcgtgggcgg aacattacag gccgcgacta tttgcgccag cagccaccaa     2940

ttcctgtcca ctcactacaa cctccacaac ctttatggat taaccgaagc tattgcaagt     3000

cacagggctc tggtgaaggc tagagggact aggccctttg tgatctcccg atccaccttt     3060

gccggacacg ggagatacgc cggtcactgg actggtgacg tgtggagctc atgggaacaa     3120

ctggcctcct ccgtgccgga aatcttacag ttcaaccttc tgggtgtccc tcttgtcgga     3180

gcagacgtgt gtgggtttct tggtaacacc tccgaggaac tgtgtgtgcg ctggactcaa     3240

ctgggtgcat tctacccatt catgagaaac cacaactcct tgctgtccct gccacaagag     3300

ccctactcgt tcagcgagcc tgcacaacag gctatgcgga aggcactgac cctgagatac     3360

gccctgcttc cacacttata cactctcttc catcaagcgc atgtggcagg agaaaccgtt     3420

gcaaggcctc ttttccttga attccccaag gattcctcga cttggacggt ggatcatcag     3480

ctgctgtggg gagaagctct gctgattact ccagtgttgc aagccggaaa agctgaggtg     3540

accggatact ttccgctggg aacctggtac gacctccaga ctgtccctgt tgaagccctt     3600

ggatcactgc ctccgcctcc ggcagctcca cgcgaaccag ctatacattc cgagggacag     3660

tgggttacat taccagctcc tctggacaca atcaacgtcc acttaagagc tggctacatt     3720

atccctctgc aaggaccagg actgactacg accgagagca gacagcagcc aatggcactg     3780

gctgtggctc tgaccaaggg aggggaagct agaggagaac tcttctggga tgatggggag     3840

tcccttgaag tgctggaaag aggcgcttac actcaagtca ttttccttgc acggaacaac     3900

accattgtga acgaattggt gcgagtgacc agcgaaggag ctggacttca actgcagaag     3960

gtcactgtgc tcggagtggc taccgctcct cagcaagtgc tgtcgaatgg agtccccgtg     4020

tcaaacttta cctactcccc tgacactaag gtgctcgaca tttgcgtgtc cctcctgatg     4080

ggagagcagt tccttgtgtc ctggtgttga ctcgagagat ctaccggtga attcaccgcg     4140

ggtttaaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     4200

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     4260

gcattgtctg agtaggtgtc attctattct ggggggtggg gtgggggcta gctctaga       4318


<210> 25
<211> 4300
<212> DNA
<213> artificial


<220> 
<223> construct: sp7+hGAAco1-delta-8

<400> 25
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc      780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat      840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat      900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat      960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt     1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta     1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg     1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat     1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca     1260

ctttggcaaa gcacgcgtgc caccatggcc tttctgtggc tgctgagctg ttgggccctg     1320

ctgggcacca ccttcggcct actagtgccc agagagctga gcggcagctc tcccgtgctg     1380

gaagaaacac accctgccca tcagcagggc gcctctagac ctggacctag agatgcccag     1440

gcccaccccg gcagacctag agctgtgcct acccagtgtg acgtgccccc caacagcaga     1500

ttcgactgcg cccctgacaa ggccatcacc caggaacagt gcgaggccag aggctgctgc     1560

tacatccctg ccaagcaggg actgcagggc gctcagatgg gacagccctg gtgcttcttc     1620

ccaccctcct accccagcta caagctggaa aacctgagca gcagcgagat gggctacacc     1680

gccaccctga ccagaaccac ccccacattc ttcccaaagg acatcctgac cctgcggctg     1740

gacgtgatga tggaaaccga gaaccggctg cacttcacca tcaaggaccc cgccaatcgg     1800

agatacgagg tgcccctgga aaccccccac gtgcactcta gagcccccag ccctctgtac     1860

agcgtggaat tcagcgagga acccttcggc gtgatcgtgc ggagacagct ggatggcaga     1920

gtgctgctga acaccaccgt ggcccctctg ttcttcgccg accagttcct gcagctgagc     1980

accagcctgc ccagccagta catcacagga ctggccgagc acctgagccc cctgatgctg     2040

agcacatcct ggacccggat caccctgtgg aacagggatc tggcccctac ccctggcgcc     2100

aatctgtacg gcagccaccc tttctacctg gccctggaag atggcggatc tgcccacgga     2160

gtgtttctgc tgaactccaa cgccatggac gtggtgctgc agcctagccc tgccctgtct     2220

tggagaagca caggcggcat cctggatgtg tacatctttc tgggccccga gcccaagagc     2280

gtggtgcagc agtatctgga tgtcgtgggc taccccttca tgccccctta ctggggcctg     2340

ggattccacc tgtgcagatg gggctactcc agcaccgcca tcaccagaca ggtggtggaa     2400

aacatgacca gagcccactt cccactggat gtgcagtgga acgacctgga ctacatggac     2460

agcagacggg acttcacctt caacaaggac ggcttccggg acttccccgc catggtgcag     2520

gaactgcatc agggcggcag acggtacatg atgatcgtgg atcccgccat cagctcctct     2580

ggccctgccg gctcttacag accctacgac gagggcctgc ggagaggcgt gttcatcacc     2640

aacgagacag gccagcccct gatcggcaaa gtgtggcctg gcagcacagc cttccccgac     2700

ttcaccaatc ctaccgccct ggcttggtgg gaggacatgg tggccgagtt ccacgaccag     2760

gtgcccttcg acggcatgtg gatcgacatg aacgagccca gcaacttcat ccggggcagc     2820

gaggatggct gccccaacaa cgaactggaa aatccccctt acgtgcccgg cgtcgtgggc     2880

ggaacactgc aggccgctac aatctgtgcc agcagccacc agtttctgag cacccactac     2940

aacctgcaca acctgtacgg cctgaccgag gccattgcca gccaccgcgc tctcgtgaaa     3000

gccagaggca cacggccctt cgtgatcagc agaagcacct ttgccggcca cggcagatac     3060

gccggacatt ggactggcga cgtgtggtcc tcttgggagc agctggcctc tagcgtgccc     3120

gagatcctgc agttcaatct gctgggcgtg ccactcgtgg gcgccgatgt gtgtggcttc     3180

ctgggcaaca cctccgagga actgtgtgtg cggtggacac agctgggcgc cttctaccct     3240

ttcatgagaa accacaacag cctgctgagc ctgccccagg aaccctacag ctttagcgag     3300

cctgcacagc aggccatgcg gaaggccctg acactgagat acgctctgct gccccacctg     3360

tacaccctgt ttcaccaggc ccatgtggcc ggcgagacag tggccagacc tctgtttctg     3420

gaattcccca aggacagcag cacctggacc gtggaccatc agctgctgtg gggagaggct     3480

ctgctgatta ccccagtgct gcaggcaggc aaggccgaag tgaccggcta ctttcccctg     3540

ggcacttggt acgacctgca gaccgtgcct gtggaagccc tgggatctct gcctccacct     3600

cctgccgctc ctagagagcc tgccattcac tctgagggcc agtgggtcac actgcctgcc     3660

cccctggata ccatcaacgt gcacctgagg gccggctaca tcataccact gcagggacct     3720

ggcctgacca ccaccgagtc tagacagcag ccaatggccc tggccgtggc cctgaccaaa     3780

ggcggagaag ctaggggcga gctgttctgg gacgatggcg agagcctgga agtgctggaa     3840

agaggcgcct atacccaagt gatcttcctg gcccggaaca acaccatcgt gaacgagctg     3900

gtgcgcgtga cctctgaagg cgctggactg cagctgcaga aagtgaccgt gctgggagtg     3960

gccacagccc ctcagcaggt gctgtctaat ggcgtgcccg tgtccaactt cacctacagc     4020

cccgacacca aggtgctgga catctgcgtg tcactgctga tgggagagca gtttctggtg     4080

tcctggtgct gactcgagag atctaccggt gaattcaccg cgggtttaaa ctgtgccttc     4140

tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc     4200

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg     4260

tcattctatt ctggggggtg gggtgggggc tagctctaga                           4300


<210> 26
<211> 4198
<212> DNA
<213> artificial


<220> 
<223> sp7+hGAAco1-delta-42

<400> 26
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc      780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat      840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat      900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat      960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt     1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta     1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg     1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat     1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca     1260

ctttggcaaa gcacgcgtgc caccatggcc tttctgtggc tgctgagctg ttgggccctg     1320

ctgggcacca ccttcggcgc ccaccccggc agacctagag ctgtgcctac ccagtgtgac     1380

gtgcccccca acagcagatt cgactgcgcc cctgacaagg ccatcaccca ggaacagtgc     1440

gaggccagag gctgctgcta catccctgcc aagcagggac tgcagggcgc tcagatggga     1500

cagccctggt gcttcttccc accctcctac cccagctaca agctggaaaa cctgagcagc     1560

agcgagatgg gctacaccgc caccctgacc agaaccaccc ccacattctt cccaaaggac     1620

atcctgaccc tgcggctgga cgtgatgatg gaaaccgaga accggctgca cttcaccatc     1680

aaggaccccg ccaatcggag atacgaggtg cccctggaaa ccccccacgt gcactctaga     1740

gcccccagcc ctctgtacag cgtggaattc agcgaggaac ccttcggcgt gatcgtgcgg     1800

agacagctgg atggcagagt gctgctgaac accaccgtgg cccctctgtt cttcgccgac     1860

cagttcctgc agctgagcac cagcctgccc agccagtaca tcacaggact ggccgagcac     1920

ctgagccccc tgatgctgag cacatcctgg acccggatca ccctgtggaa cagggatctg     1980

gcccctaccc ctggcgccaa tctgtacggc agccaccctt tctacctggc cctggaagat     2040

ggcggatctg cccacggagt gtttctgctg aactccaacg ccatggacgt ggtgctgcag     2100

cctagccctg ccctgtcttg gagaagcaca ggcggcatcc tggatgtgta catctttctg     2160

ggccccgagc ccaagagcgt ggtgcagcag tatctggatg tcgtgggcta ccccttcatg     2220

cccccttact ggggcctggg attccacctg tgcagatggg gctactccag caccgccatc     2280

accagacagg tggtggaaaa catgaccaga gcccacttcc cactggatgt gcagtggaac     2340

gacctggact acatggacag cagacgggac ttcaccttca acaaggacgg cttccgggac     2400

ttccccgcca tggtgcagga actgcatcag ggcggcagac ggtacatgat gatcgtggat     2460

cccgccatca gctcctctgg ccctgccggc tcttacagac cctacgacga gggcctgcgg     2520

agaggcgtgt tcatcaccaa cgagacaggc cagcccctga tcggcaaagt gtggcctggc     2580

agcacagcct tccccgactt caccaatcct accgccctgg cttggtggga ggacatggtg     2640

gccgagttcc acgaccaggt gcccttcgac ggcatgtgga tcgacatgaa cgagcccagc     2700

aacttcatcc ggggcagcga ggatggctgc cccaacaacg aactggaaaa tcccccttac     2760

gtgcccggcg tcgtgggcgg aacactgcag gccgctacaa tctgtgccag cagccaccag     2820

tttctgagca cccactacaa cctgcacaac ctgtacggcc tgaccgaggc cattgccagc     2880

caccgcgctc tcgtgaaagc cagaggcaca cggcccttcg tgatcagcag aagcaccttt     2940

gccggccacg gcagatacgc cggacattgg actggcgacg tgtggtcctc ttgggagcag     3000

ctggcctcta gcgtgcccga gatcctgcag ttcaatctgc tgggcgtgcc actcgtgggc     3060

gccgatgtgt gtggcttcct gggcaacacc tccgaggaac tgtgtgtgcg gtggacacag     3120

ctgggcgcct tctacccttt catgagaaac cacaacagcc tgctgagcct gccccaggaa     3180

ccctacagct ttagcgagcc tgcacagcag gccatgcgga aggccctgac actgagatac     3240

gctctgctgc cccacctgta caccctgttt caccaggccc atgtggccgg cgagacagtg     3300

gccagacctc tgtttctgga attccccaag gacagcagca cctggaccgt ggaccatcag     3360

ctgctgtggg gagaggctct gctgattacc ccagtgctgc aggcaggcaa ggccgaagtg     3420

accggctact ttcccctggg cacttggtac gacctgcaga ccgtgcctgt ggaagccctg     3480

ggatctctgc ctccacctcc tgccgctcct agagagcctg ccattcactc tgagggccag     3540

tgggtcacac tgcctgcccc cctggatacc atcaacgtgc acctgagggc cggctacatc     3600

ataccactgc agggacctgg cctgaccacc accgagtcta gacagcagcc aatggccctg     3660

gccgtggccc tgaccaaagg cggagaagct aggggcgagc tgttctggga cgatggcgag     3720

agcctggaag tgctggaaag aggcgcctat acccaagtga tcttcctggc ccggaacaac     3780

accatcgtga acgagctggt gcgcgtgacc tctgaaggcg ctggactgca gctgcagaaa     3840

gtgaccgtgc tgggagtggc cacagcccct cagcaggtgc tgtctaatgg cgtgcccgtg     3900

tccaacttca cctacagccc cgacaccaag gtgctggaca tctgcgtgtc actgctgatg     3960

ggagagcagt ttctggtgtc ctggtgctga ctcgagagat ctaccggtga attcaccgcg     4020

ggtttaaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     4080

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     4140

gcattgtctg agtaggtgtc attctattct ggggggtggg gtgggggcta gctctaga       4198


<210> 27
<211> 917
<212> PRT
<213> artificial


<220> 
<223> hGAA-delta-8

<400> 27
Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val Leu Glu Glu 
1               5                   10                  15      
Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly Pro Arg Asp 
            20                  25                  30          
Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp 
        35                  40                  45              
Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr 
    50                  55                  60                  
Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln 
65                  70                  75                  80  
Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro 
                85                  90                  95      
Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly 
            100                 105                 110         
Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp 
        115                 120                 125             
Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu 
    130                 135                 140                 
His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu 
145                 150                 155                 160 
Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val 
                165                 170                 175     
Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp 
            180                 185                 190         
Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp 
        195                 200                 205             
Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly 
    210                 215                 220                 
Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg 
225                 230                 235                 240 
Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu 
                245                 250                 255     
Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala 
            260                 265                 270         
His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln 
        275                 280                 285             
Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val 
    290                 295                 300                 
Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu 
305                 310                 315                 320 
Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe 
                325                 330                 335     
His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val 
            340                 345                 350         
Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn 
        355                 360                 365             
Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp 
    370                 375                 380                 
Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly 
385                 390                 395                 400 
Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro 
                405                 410                 415     
Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe 
            420                 425                 430         
Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly 
        435                 440                 445             
Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp 
    450                 455                 460                 
Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met 
465                 470                 475                 480 
Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp 
                485                 490                 495     
Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val 
            500                 505                 510         
Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln 
        515                 520                 525             
Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu 
    530                 535                 540                 
Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro 
545                 550                 555                 560 
Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly 
                565                 570                 575     
His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser 
            580                 585                 590         
Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly 
        595                 600                 605             
Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val 
    610                 615                 620                 
Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn 
625                 630                 635                 640 
Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala 
                645                 650                 655     
Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro 
            660                 665                 670         
His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val 
        675                 680                 685             
Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr 
    690                 695                 700                 
Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val 
705                 710                 715                 720 
Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr 
                725                 730                 735     
Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro 
            740                 745                 750         
Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln 
        755                 760                 765             
Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg 
    770                 775                 780                 
Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu 
785                 790                 795                 800 
Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly 
                805                 810                 815     
Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val 
            820                 825                 830         
Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn 
        835                 840                 845             
Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu 
    850                 855                 860                 
Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln 
865                 870                 875                 880 
Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp 
                885                 890                 895     
Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe 
            900                 905                 910         
Leu Val Ser Trp Cys 
        915         

<210> 28
<211> 883
<212> PRT
<213> artificial


<220> 
<223> hGAA-delta-42

<400> 28
Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro 
1               5                   10                  15      
Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu 
            20                  25                  30          
Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu 
        35                  40                  45              
Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr 
    50                  55                  60                  
Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr 
65                  70                  75                  80  
Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu 
                85                  90                  95      
Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe 
            100                 105                 110         
Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr 
        115                 120                 125             
Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe 
    130                 135                 140                 
Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg 
145                 150                 155                 160 
Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe 
                165                 170                 175     
Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala 
            180                 185                 190         
Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr 
        195                 200                 205             
Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly 
    210                 215                 220                 
Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly 
225                 230                 235                 240 
Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser 
                245                 250                 255     
Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile 
            260                 265                 270         
Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val 
        275                 280                 285             
Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu 
    290                 295                 300                 
Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu 
305                 310                 315                 320 
Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu 
                325                 330                 335     
Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe 
            340                 345                 350         
Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg 
        355                 360                 365             
Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly 
    370                 375                 380                 
Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr 
385                 390                 395                 400 
Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr 
                405                 410                 415     
Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp 
            420                 425                 430         
Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile 
        435                 440                 445             
Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys 
    450                 455                 460                 
Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly 
465                 470                 475                 480 
Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu 
                485                 490                 495     
Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile 
            500                 505                 510         
Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val 
        515                 520                 525             
Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp 
    530                 535                 540                 
Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro 
545                 550                 555                 560 
Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp 
                565                 570                 575     
Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp 
            580                 585                 590         
Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu 
        595                 600                 605             
Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln 
    610                 615                 620                 
Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu 
625                 630                 635                 640 
Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg 
                645                 650                 655     
Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp 
            660                 665                 670         
His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln 
        675                 680                 685             
Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr 
    690                 695                 700                 
Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro 
705                 710                 715                 720 
Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val 
                725                 730                 735     
Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly 
            740                 745                 750         
Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg 
        755                 760                 765             
Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala 
    770                 775                 780                 
Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu 
785                 790                 795                 800 
Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile 
                805                 810                 815     
Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu 
            820                 825                 830         
Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu 
        835                 840                 845             
Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys 
    850                 855                 860                 
Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val 
865                 870                 875                 880 
Ser Trp Cys 
            

<210> 29
<211> 952
<212> PRT
<213> homo sapiens


<400> 29
Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      
Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          
His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              
Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  
Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  
Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      
Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         
Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             
Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 
Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 
Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     
Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         
Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             
Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 
Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 
Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     
Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         
Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             
Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 
Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 
Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     
Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         
Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             
Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 
Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 
Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     
Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         
Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             
Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 
Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 
Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     
Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         
Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             
Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 
Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 
Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     
Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         
Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             
Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 
Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 
Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     
Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         
Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             
Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 
Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 
Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     
Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         
Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             
Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Ile Glu Ala Leu Gly 
    770                 775                 780                 
Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 
Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     
His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         
Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             
Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 
Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 
Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     
Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         
Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             
Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 
Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         

<210> 30
<211> 952
<212> PRT
<213> homo sapiens


<400> 30
Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      
Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          
His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              
Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  
Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  
Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      
Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         
Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             
Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 
Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 
Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     
Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         
Val Pro Leu Glu Thr Pro Arg Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             
Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val His Arg 
    210                 215                 220                 
Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 
Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     
Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         
Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             
Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 
Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 
Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     
Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         
Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             
Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 
Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 
Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     
Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         
Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             
Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 
Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 
Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     
Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         
Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             
Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 
Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 
Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     
Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         
Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             
Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 
Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 
Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     
Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         
Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             
Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 
Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 
Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     
Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         
Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             
Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Ile Glu Ala Leu Gly 
    770                 775                 780                 
Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 
Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     
His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         
Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             
Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 
Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 
Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     
Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         
Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             
Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 
Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         

<210> 31
<211> 957
<212> PRT
<213> homo sapiens


<400> 31
Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      
Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          
His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              
Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  
Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  
Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      
Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         
Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             
Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 
Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 
Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     
Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         
Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             
Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 
Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 
Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     
Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         
Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             
Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 
Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 
Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     
Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         
Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             
Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 
Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 
Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     
Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         
Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             
Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 
Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 
Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     
Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         
Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             
Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 
Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 
Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     
Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         
Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             
Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 
Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 
Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     
Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         
Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             
Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 
Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 
Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     
Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         
Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             
Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Ile Glu Ala Leu Gly 
    770                 775                 780                 
Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 
Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     
His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         
Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             
Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 
Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 
Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     
Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         
Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             
Ser Pro Asp Thr Lys Ala Arg Gly Pro Arg Val Leu Asp Ile Cys Val 
    930                 935                 940                 
Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
945                 950                 955         

<210> 32
<211> 952
<212> PRT
<213> homo sapiens


<400> 32
Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      
Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          
His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              
Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  
Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  
Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      
Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         
Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             
Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 
Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 
Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     
Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         
Val Pro Leu Glu Thr Pro Arg Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             
Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val His Arg 
    210                 215                 220                 
Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 
Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     
Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         
Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             
Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 
Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 
Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     
Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         
Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             
Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 
Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 
Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     
Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         
Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             
Ser Gly Pro Ala Gly Ser Tyr Arg Leu Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 
Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 
Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     
Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         
Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             
Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 
Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 
Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     
Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         
Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             
Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 
Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 
Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     
Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         
Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             
Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 
Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 
Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     
Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         
Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             
Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Ile Glu Ala Leu Gly 
    770                 775                 780                 
Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 
Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     
His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         
Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             
Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 
Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 
Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     
Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         
Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             
Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 
Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         

<210> 33
<211> 925
<212> PRT
<213> artificial


<220> 
<223> variant hGAAwt w/o sp

<400> 33
Gly His Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser 
1               5                   10                  15      
Gly Ser Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly 
            20                  25                  30          
Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro 
        35                  40                  45              
Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp 
    50                  55                  60                  
Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly 
65                  70                  75                  80  
Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly 
                85                  90                  95      
Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu 
            100                 105                 110         
Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr 
        115                 120                 125             
Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val 
    130                 135                 140                 
Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala 
145                 150                 155                 160 
Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro Arg Val His Ser Arg 
                165                 170                 175     
Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly 
            180                 185                 190         
Val Ile Val His Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr 
        195                 200                 205             
Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser 
    210                 215                 220                 
Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu 
225                 230                 235                 240 
Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu 
                245                 250                 255     
Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu 
            260                 265                 270         
Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser 
        275                 280                 285             
Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg 
    290                 295                 300                 
Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro 
305                 310                 315                 320 
Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met 
                325                 330                 335     
Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser 
            340                 345                 350         
Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His 
        355                 360                 365             
Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg 
    370                 375                 380                 
Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met 
385                 390                 395                 400 
Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp 
                405                 410                 415     
Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp 
            420                 425                 430         
Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro 
        435                 440                 445             
Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr 
    450                 455                 460                 
Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His 
465                 470                 475                 480 
Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser 
                485                 490                 495     
Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu 
            500                 505                 510         
Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala 
        515                 520                 525             
Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu 
    530                 535                 540                 
His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu 
545                 550                 555                 560 
Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe 
                565                 570                 575     
Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser 
            580                 585                 590         
Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn 
        595                 600                 605             
Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly 
    610                 615                 620                 
Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe 
625                 630                 635                 640 
Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu 
                645                 650                 655     
Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu 
            660                 665                 670         
Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln 
        675                 680                 685             
Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe 
    690                 695                 700                 
Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly 
705                 710                 715                 720 
Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val 
                725                 730                 735     
Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro 
            740                 745                 750         
Ile Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu 
        755                 760                 765             
Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu 
    770                 775                 780                 
Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln 
785                 790                 795                 800 
Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu 
                805                 810                 815     
Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp 
            820                 825                 830         
Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln 
        835                 840                 845             
Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg 
    850                 855                 860                 
Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu 
865                 870                 875                 880 
Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val 
                885                 890                 895     
Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val 
            900                 905                 910         
Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
        915                 920                 925 

<210> 34
<211> 896
<212> PRT
<213> artificial


<220> 
<223> hGAA-delta-29

<400> 34
Gln Gln Gly Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro 
1               5                   10                  15      
Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser 
            20                  25                  30          
Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu 
        35                  40                  45              
Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala 
    50                  55                  60                  
Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr 
65                  70                  75                  80  
Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu 
                85                  90                  95      
Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg 
            100                 105                 110         
Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys 
        115                 120                 125             
Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val 
    130                 135                 140                 
His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu 
145                 150                 155                 160 
Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu 
                165                 170                 175     
Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu 
            180                 185                 190         
Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu 
        195                 200                 205             
Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn 
    210                 215                 220                 
Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro 
225                 230                 235                 240 
Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu 
                245                 250                 255     
Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu 
            260                 265                 270         
Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly 
        275                 280                 285             
Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr 
    290                 295                 300                 
Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp 
305                 310                 315                 320 
Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr 
                325                 330                 335     
Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met 
            340                 345                 350         
Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe 
        355                 360                 365             
Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met 
    370                 375                 380                 
Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg 
385                 390                 395                 400 
Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr 
                405                 410                 415     
Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro 
            420                 425                 430         
Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala 
        435                 440                 445             
Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn 
    450                 455                 460                 
Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn 
465                 470                 475                 480 
Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu 
                485                 490                 495     
Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His 
            500                 505                 510         
Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His 
        515                 520                 525             
Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg 
    530                 535                 540                 
Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp 
545                 550                 555                 560 
Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu 
                565                 570                 575     
Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly 
            580                 585                 590         
Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu 
        595                 600                 605             
Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu 
    610                 615                 620                 
Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg 
625                 630                 635                 640 
Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu 
                645                 650                 655     
Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe 
            660                 665                 670         
Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu 
        675                 680                 685             
Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys 
    690                 695                 700                 
Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln 
705                 710                 715                 720 
Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala 
                725                 730                 735     
Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro 
            740                 745                 750         
Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile 
        755                 760                 765             
Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro 
    770                 775                 780                 
Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu 
785                 790                 795                 800 
Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala 
                805                 810                 815     
Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu 
            820                 825                 830         
Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val 
        835                 840                 845             
Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly 
    850                 855                 860                 
Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp 
865                 870                 875                 880 
Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
                885                 890                 895     



<210> 35
<211> 882
<212> PRT
<213> artificial


<220> 
<223> hGAA-delta-43

<400> 35
His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro 
1               5                   10                  15      
Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln 
            20                  25                  30          
Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln 
        35                  40                  45              
Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro 
    50                  55                  60                  
Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala 
65                  70                  75                  80  
Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr 
                85                  90                  95      
Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr 
            100                 105                 110         
Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro 
        115                 120                 125             
His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser 
    130                 135                 140                 
Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val 
145                 150                 155                 160 
Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu 
                165                 170                 175     
Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu 
            180                 185                 190         
His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu 
        195                 200                 205             
Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser 
    210                 215                 220                 
His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val 
225                 230                 235                 240 
Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro 
                245                 250                 255     
Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe 
            260                 265                 270         
Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val 
        275                 280                 285             
Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys 
    290                 295                 300                 
Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn 
305                 310                 315                 320 
Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp 
                325                 330                 335     
Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg 
            340                 345                 350         
Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr 
        355                 360                 365             
Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser 
    370                 375                 380                 
Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn 
385                 390                 395                 400 
Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala 
                405                 410                 415     
Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met 
            420                 425                 430         
Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp 
        435                 440                 445             
Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro 
    450                 455                 460                 
Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly 
465                 470                 475                 480 
Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser 
                485                 490                 495     
Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala 
            500                 505                 510         
Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile 
        515                 520                 525             
Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr 
    530                 535                 540                 
Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu 
545                 550                 555                 560 
Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val 
                565                 570                 575     
Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr 
            580                 585                 590         
Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu 
        595                 600                 605             
Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala 
    610                 615                 620                 
Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr 
625                 630                 635                 640 
Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro 
                645                 650                 655     
Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His 
            660                 665                 670         
Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala 
        675                 680                 685             
Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp 
    690                 695                 700                 
Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro 
705                 710                 715                 720 
Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr 
                725                 730                 735     
Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr 
            740                 745                 750         
Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln 
        755                 760                 765             
Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg 
    770                 775                 780                 
Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg 
785                 790                 795                 800 
Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val 
                805                 810                 815     
Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln 
            820                 825                 830         
Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser 
        835                 840                 845             
Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val 
    850                 855                 860                 
Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser 
865                 870                 875                 880 
Trp Cys 
        

<210> 36
<211> 878
<212> PRT
<213> artificial


<220> 
<223> hGAA-delta-47

<400> 36
Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe 
1               5                   10                  15      
Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg 
            20                  25                  30          
Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met 
        35                  40                  45              
Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu 
    50                  55                  60                  
Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg 
65                  70                  75                  80  
Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp 
                85                  90                  95      
Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro 
            100                 105                 110         
Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser 
        115                 120                 125             
Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe 
    130                 135                 140                 
Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr 
145                 150                 155                 160 
Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr 
                165                 170                 175     
Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro 
            180                 185                 190         
Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp 
        195                 200                 205             
Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr 
    210                 215                 220                 
Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn 
225                 230                 235                 240 
Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp 
                245                 250                 255     
Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu 
            260                 265                 270         
Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe 
        275                 280                 285             
Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr 
    290                 295                 300                 
Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala 
305                 310                 315                 320 
His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser 
                325                 330                 335     
Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala 
            340                 345                 350         
Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val 
        355                 360                 365             
Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr 
    370                 375                 380                 
Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln 
385                 390                 395                 400 
Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe 
                405                 410                 415     
Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe 
            420                 425                 430         
His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro 
        435                 440                 445             
Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu 
    450                 455                 460                 
Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala 
465                 470                 475                 480 
Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn 
                485                 490                 495     
Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala 
            500                 505                 510         
Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr 
        515                 520                 525             
Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp 
    530                 535                 540                 
Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe 
545                 550                 555                 560 
Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu 
                565                 570                 575     
Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala 
            580                 585                 590         
Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln 
        595                 600                 605             
Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala 
    610                 615                 620                 
Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His 
625                 630                 635                 640 
Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu 
                645                 650                 655     
Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp 
            660                 665                 670         
Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu 
        675                 680                 685             
Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val 
    690                 695                 700                 
Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg 
705                 710                 715                 720 
Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro 
                725                 730                 735     
Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu 
            740                 745                 750         
Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala 
        755                 760                 765             
Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe 
    770                 775                 780                 
Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr 
785                 790                 795                 800 
Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val 
                805                 810                 815     
Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val 
            820                 825                 830         
Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro 
        835                 840                 845             
Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys 
    850                 855                 860                 
Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
865                 870                 875             

<210> 37
<211> 2745
<212> DNA
<213> artificial


<220> 
<223> sp7+hGAAwt-delta-29

<400> 37
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccagcag      60

ggagccagca gaccagggcc ccgggatgcc caggcacacc ccgggcggcc gcgagcagtg     120

cccacacagt gcgacgtccc ccccaacagc cgcttcgatt gcgcccctga caaggccatc     180

acccaggaac agtgcgaggc ccgcggctgt tgctacatcc ctgcaaagca ggggctgcag     240

ggagcccaga tggggcagcc ctggtgcttc ttcccaccca gctaccccag ctacaagctg     300

gagaacctga gctcctctga aatgggctac acggccaccc tgacccgtac cacccccacc     360

ttcttcccca aggacatcct gaccctgcgg ctggacgtga tgatggagac tgagaaccgc     420

ctccacttca cgatcaaaga tccagctaac aggcgctacg aggtgccctt ggagaccccg     480

catgtccaca gccgggcacc gtccccactc tacagcgtgg agttctccga ggagcccttc     540

ggggtgatcg tgcgccggca gctggacggc cgcgtgctgc tgaacacgac ggtggcgccc     600

ctgttctttg cggaccagtt ccttcagctg tccacctcgc tgccctcgca gtatatcaca     660

ggcctcgccg agcacctcag tcccctgatg ctcagcacca gctggaccag gatcaccctg     720

tggaaccggg accttgcgcc cacgcccggt gcgaacctct acgggtctca ccctttctac     780

ctggcgctgg aggacggcgg gtcggcacac ggggtgttcc tgctaaacag caatgccatg     840

gatgtggtcc tgcagccgag ccctgccctt agctggaggt cgacaggtgg gatcctggat     900

gtctacatct tcctgggccc agagcccaag agcgtggtgc agcagtacct ggacgttgtg     960

ggatacccgt tcatgccgcc atactggggc ctgggcttcc acctgtgccg ctggggctac    1020

tcctccaccg ctatcacccg ccaggtggtg gagaacatga ccagggccca cttccccctg    1080

gacgtccagt ggaacgacct ggactacatg gactcccgga gggacttcac gttcaacaag    1140

gatggcttcc gggacttccc ggccatggtg caggagctgc accagggcgg ccggcgctac    1200

atgatgatcg tggatcctgc catcagcagc tcgggccctg ccgggagcta caggccctac    1260

gacgagggtc tgcggagggg ggttttcatc accaacgaga ccggccagcc gctgattggg    1320

aaggtatggc ccgggtccac tgccttcccc gacttcacca accccacagc cctggcctgg    1380

tgggaggaca tggtggctga gttccatgac caggtgccct tcgacggcat gtggattgac    1440

atgaacgagc cttccaactt catcaggggc tctgaggacg gctgccccaa caatgagctg    1500

gagaacccac cctacgtgcc tggggtggtt ggggggaccc tccaggcggc caccatctgt    1560

gcctccagcc accagtttct ctccacacac tacaacctgc acaacctcta cggcctgacc    1620

gaagccatcg cctcccacag ggcgctggtg aaggctcggg ggacacgccc atttgtgatc    1680

tcccgctcga cctttgctgg ccacggccga tacgccggcc actggacggg ggacgtgtgg    1740

agctcctggg agcagctcgc ctcctccgtg ccagaaatcc tgcagtttaa cctgctgggg    1800

gtgcctctgg tcggggccga cgtctgcggc ttcctgggca acacctcaga ggagctgtgt    1860

gtgcgctgga cccagctggg ggccttctac cccttcatgc ggaaccacaa cagcctgctc    1920

agtctgcccc aggagccgta cagcttcagc gagccggccc agcaggccat gaggaaggcc    1980

ctcaccctgc gctacgcact cctcccccac ctctacacac tgttccacca ggcccacgtc    2040

gcgggggaga ccgtggcccg gcccctcttc ctggagttcc ccaaggactc tagcacctgg    2100

actgtggacc accagctcct gtggggggag gccctgctca tcaccccagt gctccaggcc    2160

gggaaggccg aagtgactgg ctacttcccc ttgggcacat ggtacgacct gcagacggtg    2220

ccagtagagg cccttggcag cctcccaccc ccacctgcag ctccccgtga gccagccatc    2280

cacagcgagg ggcagtgggt gacgctgccg gcccccctgg acaccatcaa cgtccacctc    2340

cgggctgggt acatcatccc cctgcagggc cctggcctca caaccacaga gtcccgccag    2400

cagcccatgg ccctggctgt ggccctgacc aagggtgggg aggcccgagg ggagctgttc    2460

tgggacgatg gagagagcct ggaagtgctg gagcgagggg cctacacaca ggtcatcttc    2520

ctggccagga ataacacgat cgtgaatgag ctggtacgtg tgaccagtga gggagctggc    2580

ctgcagctgc agaaggtgac tgtcctgggc gtggccacgg cgccccagca ggtcctctcc    2640

aacggtgtcc ctgtctccaa cttcacctac agccccgaca ccaaggtcct ggacatctgt    2700

gtctcgctgt tgatgggaga gcagtttctc gtcagctggt gttag                    2745


<210> 38
<211> 2745
<212> DNA
<213> artificial


<220> 
<223> sp7+hGAAco1-delta-29

<400> 38
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccagcag      60

ggcgcctcta gacctggacc tagagatgcc caggcccacc ccggcagacc tagagctgtg     120

cctacccagt gtgacgtgcc ccccaacagc agattcgact gcgcccctga caaggccatc     180

acccaggaac agtgcgaggc cagaggctgc tgctacatcc ctgccaagca gggactgcag     240

ggcgctcaga tgggacagcc ctggtgcttc ttcccaccct cctaccccag ctacaagctg     300

gaaaacctga gcagcagcga gatgggctac accgccaccc tgaccagaac cacccccaca     360

ttcttcccaa aggacatcct gaccctgcgg ctggacgtga tgatggaaac cgagaaccgg     420

ctgcacttca ccatcaagga ccccgccaat cggagatacg aggtgcccct ggaaaccccc     480

cacgtgcact ctagagcccc cagccctctg tacagcgtgg aattcagcga ggaacccttc     540

ggcgtgatcg tgcggagaca gctggatggc agagtgctgc tgaacaccac cgtggcccct     600

ctgttcttcg ccgaccagtt cctgcagctg agcaccagcc tgcccagcca gtacatcaca     660

ggactggccg agcacctgag ccccctgatg ctgagcacat cctggacccg gatcaccctg     720

tggaacaggg atctggcccc tacccctggc gccaatctgt acggcagcca ccctttctac     780

ctggccctgg aagatggcgg atctgcccac ggagtgtttc tgctgaactc caacgccatg     840

gacgtggtgc tgcagcctag ccctgccctg tcttggagaa gcacaggcgg catcctggat     900

gtgtacatct ttctgggccc cgagcccaag agcgtggtgc agcagtatct ggatgtcgtg     960

ggctacccct tcatgccccc ttactggggc ctgggattcc acctgtgcag atggggctac    1020

tccagcaccg ccatcaccag acaggtggtg gaaaacatga ccagagccca cttcccactg    1080

gatgtgcagt ggaacgacct ggactacatg gacagcagac gggacttcac cttcaacaag    1140

gacggcttcc gggacttccc cgccatggtg caggaactgc atcagggcgg cagacggtac    1200

atgatgatcg tggatcccgc catcagctcc tctggccctg ccggctctta cagaccctac    1260

gacgagggcc tgcggagagg cgtgttcatc accaacgaga caggccagcc cctgatcggc    1320

aaagtgtggc ctggcagcac agccttcccc gacttcacca atcctaccgc cctggcttgg    1380

tgggaggaca tggtggccga gttccacgac caggtgccct tcgacggcat gtggatcgac    1440

atgaacgagc ccagcaactt catccggggc agcgaggatg gctgccccaa caacgaactg    1500

gaaaatcccc cttacgtgcc cggcgtcgtg ggcggaacac tgcaggccgc tacaatctgt    1560

gccagcagcc accagtttct gagcacccac tacaacctgc acaacctgta cggcctgacc    1620

gaggccattg ccagccaccg cgctctcgtg aaagccagag gcacacggcc cttcgtgatc    1680

agcagaagca cctttgccgg ccacggcaga tacgccggac attggactgg cgacgtgtgg    1740

tcctcttggg agcagctggc ctctagcgtg cccgagatcc tgcagttcaa tctgctgggc    1800

gtgccactcg tgggcgccga tgtgtgtggc ttcctgggca acacctccga ggaactgtgt    1860

gtgcggtgga cacagctggg cgccttctac cctttcatga gaaaccacaa cagcctgctg    1920

agcctgcccc aggaacccta cagctttagc gagcctgcac agcaggccat gcggaaggcc    1980

ctgacactga gatacgctct gctgccccac ctgtacaccc tgtttcacca ggcccatgtg    2040

gccggcgaga cagtggccag acctctgttt ctggaattcc ccaaggacag cagcacctgg    2100

accgtggacc atcagctgct gtggggagag gctctgctga ttaccccagt gctgcaggca    2160

ggcaaggccg aagtgaccgg ctactttccc ctgggcactt ggtacgacct gcagaccgtg    2220

cctgtggaag ccctgggatc tctgcctcca cctcctgccg ctcctagaga gcctgccatt    2280

cactctgagg gccagtgggt cacactgcct gcccccctgg ataccatcaa cgtgcacctg    2340

agggccggct acatcatacc actgcaggga cctggcctga ccaccaccga gtctagacag    2400

cagccaatgg ccctggccgt ggccctgacc aaaggcggag aagctagggg cgagctgttc    2460

tgggacgatg gcgagagcct ggaagtgctg gaaagaggcg cctataccca agtgatcttc    2520

ctggcccgga acaacaccat cgtgaacgag ctggtgcgcg tgacctctga aggcgctgga    2580

ctgcagctgc agaaagtgac cgtgctggga gtggccacag cccctcagca ggtgctgtct    2640

aatggcgtgc ccgtgtccaa cttcacctac agccccgaca ccaaggtgct ggacatctgc    2700

gtgtcactgc tgatgggaga gcagtttctg gtgtcctggt gctga                    2745


<210> 39
<211> 2745
<212> DNA
<213> artificial


<220> 
<223> sp7+hGAAco2-delta-29

<400> 39
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccaacag      60

ggagcttcca gaccaggacc gagagacgcc caagcccatc ctggtagacc aagagctgtg     120

cctacccaat gcgacgtgcc acccaactcc cgattcgact gcgcgccaga taaggctatt     180

acccaagagc agtgtgaagc cagaggttgc tgctacatcc cagcgaagca aggattgcaa     240

ggcgcccaaa tgggacaacc ttggtgtttc ttcccccctt cgtacccatc atataaactc     300

gaaaacctgt cctcttcgga aatgggttat actgccaccc tcaccagaac tactcctact     360

ttcttcccga aagacatctt gaccttgagg ctggacgtga tgatggagac tgaaaaccgg     420

ctgcatttca ctatcaaaga tcctgccaat cggcgatacg aggtccctct ggaaacccct     480

cacgtgcact cacgggctcc ttctccgctt tactccgtcg aattctctga ggaacccttc     540

ggagtgatcg ttagacgcca gctggatggt agagtgctgt tgaacactac tgtggcccca     600

cttttcttcg ctgaccagtt tctgcaactg tccacttccc tgccatccca gtacattact     660

ggactcgccg aacacctgtc gccactgatg ctctcgacct cttggactag aatcactttg     720

tggaacagag acttggcccc tactccggga gcaaatctgt acggaagcca ccctttttac     780

ctggcgctcg aagatggcgg atccgctcac ggagtgttcc tgctgaatag caacgcaatg     840

gacgtggtgc tgcaaccttc ccctgcactc agttggagaa gtaccggggg tattctggac     900

gtgtacatct tcctcggacc agaacccaag agcgtggtgc agcaatatct ggacgtggtc     960

ggataccctt ttatgcctcc ttactgggga ctgggattcc acctttgccg ttggggctac    1020

tcatccaccg ccattaccag acaggtggtg gagaatatga ccagagccca cttccctctc    1080

gacgtgcagt ggaacgatct ggactatatg gactcccgga gagatttcac cttcaacaag    1140

gacgggttcc gcgattttcc cgcgatggtt caagagctcc accagggtgg tcgaagatat    1200

atgatgatcg tcgacccagc catttcgagc agcggacccg ctggatctta tagaccttac    1260

gacgaaggcc ttaggagagg agtgttcatc acaaacgaga ctggacagcc tttgatcggt    1320

aaagtgtggc ctggatcaac cgcctttcct gactttacca atcccactgc cttggcttgg    1380

tgggaggaca tggtggccga attccacgac caagtcccct ttgatggaat gtggatcgat    1440

atgaacgaac caagcaattt tatcagaggt tccgaagacg gttgccccaa caacgaactg    1500

gaaaaccctc cttatgtgcc cggagtcgtg ggcggaacat tacaggccgc gactatttgc    1560

gccagcagcc accaattcct gtccactcac tacaacctcc acaaccttta tggattaacc    1620

gaagctattg caagtcacag ggctctggtg aaggctagag ggactaggcc ctttgtgatc    1680

tcccgatcca cctttgccgg acacgggaga tacgccggtc actggactgg tgacgtgtgg    1740

agctcatggg aacaactggc ctcctccgtg ccggaaatct tacagttcaa ccttctgggt    1800

gtccctcttg tcggagcaga cgtgtgtggg tttcttggta acacctccga ggaactgtgt    1860

gtgcgctgga ctcaactggg tgcattctac ccattcatga gaaaccacaa ctccttgctg    1920

tccctgccac aagagcccta ctcgttcagc gagcctgcac aacaggctat gcggaaggca    1980

ctgaccctga gatacgccct gcttccacac ttatacactc tcttccatca agcgcatgtg    2040

gcaggagaaa ccgttgcaag gcctcttttc cttgaattcc ccaaggattc ctcgacttgg    2100

acggtggatc atcagctgct gtggggagaa gctctgctga ttactccagt gttgcaagcc    2160

ggaaaagctg aggtgaccgg atactttccg ctgggaacct ggtacgacct ccagactgtc    2220

cctgttgaag cccttggatc actgcctccg cctccggcag ctccacgcga accagctata    2280

cattccgagg gacagtgggt tacattacca gctcctctgg acacaatcaa cgtccactta    2340

agagctggct acattatccc tctgcaagga ccaggactga ctacgaccga gagcagacag    2400

cagccaatgg cactggctgt ggctctgacc aagggagggg aagctagagg agaactcttc    2460

tgggatgatg gggagtccct tgaagtgctg gaaagaggcg cttacactca agtcattttc    2520

cttgcacgga acaacaccat tgtgaacgaa ttggtgcgag tgaccagcga aggagctgga    2580

cttcaactgc agaaggtcac tgtgctcgga gtggctaccg ctcctcagca agtgctgtcg    2640

aatggagtcc ccgtgtcaaa ctttacctac tcccctgaca ctaaggtgct cgacatttgc    2700

gtgtccctcc tgatgggaga gcagttcctt gtgtcctggt gttga                    2745


<210> 40
<211> 2706
<212> DNA
<213> artificial


<220> 
<223> sp7+hGAAwt-delta-42

<400> 40
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggcgcacac      60

cccgggcggc cgcgagcagt gcccacacag tgcgacgtcc cccccaacag ccgcttcgat     120

tgcgcccctg acaaggccat cacccaggaa cagtgcgagg cccgcggctg ttgctacatc     180

cctgcaaagc aggggctgca gggagcccag atggggcagc cctggtgctt cttcccaccc     240

agctacccca gctacaagct ggagaacctg agctcctctg aaatgggcta cacggccacc     300

ctgacccgta ccacccccac cttcttcccc aaggacatcc tgaccctgcg gctggacgtg     360

atgatggaga ctgagaaccg cctccacttc acgatcaaag atccagctaa caggcgctac     420

gaggtgccct tggagacccc gcatgtccac agccgggcac cgtccccact ctacagcgtg     480

gagttctccg aggagccctt cggggtgatc gtgcgccggc agctggacgg ccgcgtgctg     540

ctgaacacga cggtggcgcc cctgttcttt gcggaccagt tccttcagct gtccacctcg     600

ctgccctcgc agtatatcac aggcctcgcc gagcacctca gtcccctgat gctcagcacc     660

agctggacca ggatcaccct gtggaaccgg gaccttgcgc ccacgcccgg tgcgaacctc     720

tacgggtctc accctttcta cctggcgctg gaggacggcg ggtcggcaca cggggtgttc     780

ctgctaaaca gcaatgccat ggatgtggtc ctgcagccga gccctgccct tagctggagg     840

tcgacaggtg ggatcctgga tgtctacatc ttcctgggcc cagagcccaa gagcgtggtg     900

cagcagtacc tggacgttgt gggatacccg ttcatgccgc catactgggg cctgggcttc     960

cacctgtgcc gctggggcta ctcctccacc gctatcaccc gccaggtggt ggagaacatg    1020

accagggccc acttccccct ggacgtccag tggaacgacc tggactacat ggactcccgg    1080

agggacttca cgttcaacaa ggatggcttc cgggacttcc cggccatggt gcaggagctg    1140

caccagggcg gccggcgcta catgatgatc gtggatcctg ccatcagcag ctcgggccct    1200

gccgggagct acaggcccta cgacgagggt ctgcggaggg gggttttcat caccaacgag    1260

accggccagc cgctgattgg gaaggtatgg cccgggtcca ctgccttccc cgacttcacc    1320

aaccccacag ccctggcctg gtgggaggac atggtggctg agttccatga ccaggtgccc    1380

ttcgacggca tgtggattga catgaacgag ccttccaact tcatcagggg ctctgaggac    1440

ggctgcccca acaatgagct ggagaaccca ccctacgtgc ctggggtggt tggggggacc    1500

ctccaggcgg ccaccatctg tgcctccagc caccagtttc tctccacaca ctacaacctg    1560

cacaacctct acggcctgac cgaagccatc gcctcccaca gggcgctggt gaaggctcgg    1620

gggacacgcc catttgtgat ctcccgctcg acctttgctg gccacggccg atacgccggc    1680

cactggacgg gggacgtgtg gagctcctgg gagcagctcg cctcctccgt gccagaaatc    1740

ctgcagttta acctgctggg ggtgcctctg gtcggggccg acgtctgcgg cttcctgggc    1800

aacacctcag aggagctgtg tgtgcgctgg acccagctgg gggccttcta ccccttcatg    1860

cggaaccaca acagcctgct cagtctgccc caggagccgt acagcttcag cgagccggcc    1920

cagcaggcca tgaggaaggc cctcaccctg cgctacgcac tcctccccca cctctacaca    1980

ctgttccacc aggcccacgt cgcgggggag accgtggccc ggcccctctt cctggagttc    2040

cccaaggact ctagcacctg gactgtggac caccagctcc tgtgggggga ggccctgctc    2100

atcaccccag tgctccaggc cgggaaggcc gaagtgactg gctacttccc cttgggcaca    2160

tggtacgacc tgcagacggt gccagtagag gcccttggca gcctcccacc cccacctgca    2220

gctccccgtg agccagccat ccacagcgag gggcagtggg tgacgctgcc ggcccccctg    2280

gacaccatca acgtccacct ccgggctggg tacatcatcc ccctgcaggg ccctggcctc    2340

acaaccacag agtcccgcca gcagcccatg gccctggctg tggccctgac caagggtggg    2400

gaggcccgag gggagctgtt ctgggacgat ggagagagcc tggaagtgct ggagcgaggg    2460

gcctacacac aggtcatctt cctggccagg aataacacga tcgtgaatga gctggtacgt    2520

gtgaccagtg agggagctgg cctgcagctg cagaaggtga ctgtcctggg cgtggccacg    2580

gcgccccagc aggtcctctc caacggtgtc cctgtctcca acttcaccta cagccccgac    2640

accaaggtcc tggacatctg tgtctcgctg ttgatgggag agcagtttct cgtcagctgg    2700

tgttag                                                               2706


<210> 41
<211> 2706
<212> DNA
<213> artificial


<220> 
<223> sp7-hGAAco2-delta-42

<400> 41
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggcgcccat      60

cctggtagac caagagctgt gcctacccaa tgcgacgtgc cacccaactc ccgattcgac     120

tgcgcgccag ataaggctat tacccaagag cagtgtgaag ccagaggttg ctgctacatc     180

ccagcgaagc aaggattgca aggcgcccaa atgggacaac cttggtgttt cttcccccct     240

tcgtacccat catataaact cgaaaacctg tcctcttcgg aaatgggtta tactgccacc     300

ctcaccagaa ctactcctac tttcttcccg aaagacatct tgaccttgag gctggacgtg     360

atgatggaga ctgaaaaccg gctgcatttc actatcaaag atcctgccaa tcggcgatac     420

gaggtccctc tggaaacccc tcacgtgcac tcacgggctc cttctccgct ttactccgtc     480

gaattctctg aggaaccctt cggagtgatc gttagacgcc agctggatgg tagagtgctg     540

ttgaacacta ctgtggcccc acttttcttc gctgaccagt ttctgcaact gtccacttcc     600

ctgccatccc agtacattac tggactcgcc gaacacctgt cgccactgat gctctcgacc     660

tcttggacta gaatcacttt gtggaacaga gacttggccc ctactccggg agcaaatctg     720

tacggaagcc acccttttta cctggcgctc gaagatggcg gatccgctca cggagtgttc     780

ctgctgaata gcaacgcaat ggacgtggtg ctgcaacctt cccctgcact cagttggaga     840

agtaccgggg gtattctgga cgtgtacatc ttcctcggac cagaacccaa gagcgtggtg     900

cagcaatatc tggacgtggt cggataccct tttatgcctc cttactgggg actgggattc     960

cacctttgcc gttggggcta ctcatccacc gccattacca gacaggtggt ggagaatatg    1020

accagagccc acttccctct cgacgtgcag tggaacgatc tggactatat ggactcccgg    1080

agagatttca ccttcaacaa ggacgggttc cgcgattttc ccgcgatggt tcaagagctc    1140

caccagggtg gtcgaagata tatgatgatc gtcgacccag ccatttcgag cagcggaccc    1200

gctggatctt atagacctta cgacgaaggc cttaggagag gagtgttcat cacaaacgag    1260

actggacagc ctttgatcgg taaagtgtgg cctggatcaa ccgcctttcc tgactttacc    1320

aatcccactg ccttggcttg gtgggaggac atggtggccg aattccacga ccaagtcccc    1380

tttgatggaa tgtggatcga tatgaacgaa ccaagcaatt ttatcagagg ttccgaagac    1440

ggttgcccca acaacgaact ggaaaaccct ccttatgtgc ccggagtcgt gggcggaaca    1500

ttacaggccg cgactatttg cgccagcagc caccaattcc tgtccactca ctacaacctc    1560

cacaaccttt atggattaac cgaagctatt gcaagtcaca gggctctggt gaaggctaga    1620

gggactaggc cctttgtgat ctcccgatcc acctttgccg gacacgggag atacgccggt    1680

cactggactg gtgacgtgtg gagctcatgg gaacaactgg cctcctccgt gccggaaatc    1740

ttacagttca accttctggg tgtccctctt gtcggagcag acgtgtgtgg gtttcttggt    1800

aacacctccg aggaactgtg tgtgcgctgg actcaactgg gtgcattcta cccattcatg    1860

agaaaccaca actccttgct gtccctgcca caagagccct actcgttcag cgagcctgca    1920

caacaggcta tgcggaaggc actgaccctg agatacgccc tgcttccaca cttatacact    1980

ctcttccatc aagcgcatgt ggcaggagaa accgttgcaa ggcctctttt ccttgaattc    2040

cccaaggatt cctcgacttg gacggtggat catcagctgc tgtggggaga agctctgctg    2100

attactccag tgttgcaagc cggaaaagct gaggtgaccg gatactttcc gctgggaacc    2160

tggtacgacc tccagactgt ccctgttgaa gcccttggat cactgcctcc gcctccggca    2220

gctccacgcg aaccagctat acattccgag ggacagtggg ttacattacc agctcctctg    2280

gacacaatca acgtccactt aagagctggc tacattatcc ctctgcaagg accaggactg    2340

actacgaccg agagcagaca gcagccaatg gcactggctg tggctctgac caagggaggg    2400

gaagctagag gagaactctt ctgggatgat ggggagtccc ttgaagtgct ggaaagaggc    2460

gcttacactc aagtcatttt ccttgcacgg aacaacacca ttgtgaacga attggtgcga    2520

gtgaccagcg aaggagctgg acttcaactg cagaaggtca ctgtgctcgg agtggctacc    2580

gctcctcagc aagtgctgtc gaatggagtc cccgtgtcaa actttaccta ctcccctgac    2640

actaaggtgc tcgacatttg cgtgtccctc ctgatgggag agcagttcct tgtgtcctgg    2700

tgttga                                                               2706


<210> 42
<211> 2703
<212> DNA
<213> artificial


<220> 
<223> sp7-hGAAwt-delta-43

<400> 42
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccacccc      60

gggcggccgc gagcagtgcc cacacagtgc gacgtccccc ccaacagccg cttcgattgc     120

gcccctgaca aggccatcac ccaggaacag tgcgaggccc gcggctgttg ctacatccct     180

gcaaagcagg ggctgcaggg agcccagatg gggcagccct ggtgcttctt cccacccagc     240

taccccagct acaagctgga gaacctgagc tcctctgaaa tgggctacac ggccaccctg     300

acccgtacca cccccacctt cttccccaag gacatcctga ccctgcggct ggacgtgatg     360

atggagactg agaaccgcct ccacttcacg atcaaagatc cagctaacag gcgctacgag     420

gtgcccttgg agaccccgca tgtccacagc cgggcaccgt ccccactcta cagcgtggag     480

ttctccgagg agcccttcgg ggtgatcgtg cgccggcagc tggacggccg cgtgctgctg     540

aacacgacgg tggcgcccct gttctttgcg gaccagttcc ttcagctgtc cacctcgctg     600

ccctcgcagt atatcacagg cctcgccgag cacctcagtc ccctgatgct cagcaccagc     660

tggaccagga tcaccctgtg gaaccgggac cttgcgccca cgcccggtgc gaacctctac     720

gggtctcacc ctttctacct ggcgctggag gacggcgggt cggcacacgg ggtgttcctg     780

ctaaacagca atgccatgga tgtggtcctg cagccgagcc ctgcccttag ctggaggtcg     840

acaggtggga tcctggatgt ctacatcttc ctgggcccag agcccaagag cgtggtgcag     900

cagtacctgg acgttgtggg atacccgttc atgccgccat actggggcct gggcttccac     960

ctgtgccgct ggggctactc ctccaccgct atcacccgcc aggtggtgga gaacatgacc    1020

agggcccact tccccctgga cgtccagtgg aacgacctgg actacatgga ctcccggagg    1080

gacttcacgt tcaacaagga tggcttccgg gacttcccgg ccatggtgca ggagctgcac    1140

cagggcggcc ggcgctacat gatgatcgtg gatcctgcca tcagcagctc gggccctgcc    1200

gggagctaca ggccctacga cgagggtctg cggagggggg ttttcatcac caacgagacc    1260

ggccagccgc tgattgggaa ggtatggccc gggtccactg ccttccccga cttcaccaac    1320

cccacagccc tggcctggtg ggaggacatg gtggctgagt tccatgacca ggtgcccttc    1380

gacggcatgt ggattgacat gaacgagcct tccaacttca tcaggggctc tgaggacggc    1440

tgccccaaca atgagctgga gaacccaccc tacgtgcctg gggtggttgg ggggaccctc    1500

caggcggcca ccatctgtgc ctccagccac cagtttctct ccacacacta caacctgcac    1560

aacctctacg gcctgaccga agccatcgcc tcccacaggg cgctggtgaa ggctcggggg    1620

acacgcccat ttgtgatctc ccgctcgacc tttgctggcc acggccgata cgccggccac    1680

tggacggggg acgtgtggag ctcctgggag cagctcgcct cctccgtgcc agaaatcctg    1740

cagtttaacc tgctgggggt gcctctggtc ggggccgacg tctgcggctt cctgggcaac    1800

acctcagagg agctgtgtgt gcgctggacc cagctggggg ccttctaccc cttcatgcgg    1860

aaccacaaca gcctgctcag tctgccccag gagccgtaca gcttcagcga gccggcccag    1920

caggccatga ggaaggccct caccctgcgc tacgcactcc tcccccacct ctacacactg    1980

ttccaccagg cccacgtcgc gggggagacc gtggcccggc ccctcttcct ggagttcccc    2040

aaggactcta gcacctggac tgtggaccac cagctcctgt ggggggaggc cctgctcatc    2100

accccagtgc tccaggccgg gaaggccgaa gtgactggct acttcccctt gggcacatgg    2160

tacgacctgc agacggtgcc agtagaggcc cttggcagcc tcccaccccc acctgcagct    2220

ccccgtgagc cagccatcca cagcgagggg cagtgggtga cgctgccggc ccccctggac    2280

accatcaacg tccacctccg ggctgggtac atcatccccc tgcagggccc tggcctcaca    2340

accacagagt cccgccagca gcccatggcc ctggctgtgg ccctgaccaa gggtggggag    2400

gcccgagggg agctgttctg ggacgatgga gagagcctgg aagtgctgga gcgaggggcc    2460

tacacacagg tcatcttcct ggccaggaat aacacgatcg tgaatgagct ggtacgtgtg    2520

accagtgagg gagctggcct gcagctgcag aaggtgactg tcctgggcgt ggccacggcg    2580

ccccagcagg tcctctccaa cggtgtccct gtctccaact tcacctacag ccccgacacc    2640

aaggtcctgg acatctgtgt ctcgctgttg atgggagagc agtttctcgt cagctggtgt    2700

tag                                                                  2703


<210> 43
<211> 2703
<212> DNA
<213> artificial


<220> 
<223> sp7+hGAAco1-delta-43

<400> 43
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccacccc      60

ggcagaccta gagctgtgcc tacccagtgt gacgtgcccc ccaacagcag attcgactgc     120

gcccctgaca aggccatcac ccaggaacag tgcgaggcca gaggctgctg ctacatccct     180

gccaagcagg gactgcaggg cgctcagatg ggacagccct ggtgcttctt cccaccctcc     240

taccccagct acaagctgga aaacctgagc agcagcgaga tgggctacac cgccaccctg     300

accagaacca cccccacatt cttcccaaag gacatcctga ccctgcggct ggacgtgatg     360

atggaaaccg agaaccggct gcacttcacc atcaaggacc ccgccaatcg gagatacgag     420

gtgcccctgg aaacccccca cgtgcactct agagccccca gccctctgta cagcgtggaa     480

ttcagcgagg aacccttcgg cgtgatcgtg cggagacagc tggatggcag agtgctgctg     540

aacaccaccg tggcccctct gttcttcgcc gaccagttcc tgcagctgag caccagcctg     600

cccagccagt acatcacagg actggccgag cacctgagcc ccctgatgct gagcacatcc     660

tggacccgga tcaccctgtg gaacagggat ctggccccta cccctggcgc caatctgtac     720

ggcagccacc ctttctacct ggccctggaa gatggcggat ctgcccacgg agtgtttctg     780

ctgaactcca acgccatgga cgtggtgctg cagcctagcc ctgccctgtc ttggagaagc     840

acaggcggca tcctggatgt gtacatcttt ctgggccccg agcccaagag cgtggtgcag     900

cagtatctgg atgtcgtggg ctaccccttc atgccccctt actggggcct gggattccac     960

ctgtgcagat ggggctactc cagcaccgcc atcaccagac aggtggtgga aaacatgacc    1020

agagcccact tcccactgga tgtgcagtgg aacgacctgg actacatgga cagcagacgg    1080

gacttcacct tcaacaagga cggcttccgg gacttccccg ccatggtgca ggaactgcat    1140

cagggcggca gacggtacat gatgatcgtg gatcccgcca tcagctcctc tggccctgcc    1200

ggctcttaca gaccctacga cgagggcctg cggagaggcg tgttcatcac caacgagaca    1260

ggccagcccc tgatcggcaa agtgtggcct ggcagcacag ccttccccga cttcaccaat    1320

cctaccgccc tggcttggtg ggaggacatg gtggccgagt tccacgacca ggtgcccttc    1380

gacggcatgt ggatcgacat gaacgagccc agcaacttca tccggggcag cgaggatggc    1440

tgccccaaca acgaactgga aaatccccct tacgtgcccg gcgtcgtggg cggaacactg    1500

caggccgcta caatctgtgc cagcagccac cagtttctga gcacccacta caacctgcac    1560

aacctgtacg gcctgaccga ggccattgcc agccaccgcg ctctcgtgaa agccagaggc    1620

acacggccct tcgtgatcag cagaagcacc tttgccggcc acggcagata cgccggacat    1680

tggactggcg acgtgtggtc ctcttgggag cagctggcct ctagcgtgcc cgagatcctg    1740

cagttcaatc tgctgggcgt gccactcgtg ggcgccgatg tgtgtggctt cctgggcaac    1800

acctccgagg aactgtgtgt gcggtggaca cagctgggcg ccttctaccc tttcatgaga    1860

aaccacaaca gcctgctgag cctgccccag gaaccctaca gctttagcga gcctgcacag    1920

caggccatgc ggaaggccct gacactgaga tacgctctgc tgccccacct gtacaccctg    1980

tttcaccagg cccatgtggc cggcgagaca gtggccagac ctctgtttct ggaattcccc    2040

aaggacagca gcacctggac cgtggaccat cagctgctgt ggggagaggc tctgctgatt    2100

accccagtgc tgcaggcagg caaggccgaa gtgaccggct actttcccct gggcacttgg    2160

tacgacctgc agaccgtgcc tgtggaagcc ctgggatctc tgcctccacc tcctgccgct    2220

cctagagagc ctgccattca ctctgagggc cagtgggtca cactgcctgc ccccctggat    2280

accatcaacg tgcacctgag ggccggctac atcataccac tgcagggacc tggcctgacc    2340

accaccgagt ctagacagca gccaatggcc ctggccgtgg ccctgaccaa aggcggagaa    2400

gctaggggcg agctgttctg ggacgatggc gagagcctgg aagtgctgga aagaggcgcc    2460

tatacccaag tgatcttcct ggcccggaac aacaccatcg tgaacgagct ggtgcgcgtg    2520

acctctgaag gcgctggact gcagctgcag aaagtgaccg tgctgggagt ggccacagcc    2580

cctcagcagg tgctgtctaa tggcgtgccc gtgtccaact tcacctacag ccccgacacc    2640

aaggtgctgg acatctgcgt gtcactgctg atgggagagc agtttctggt gtcctggtgc    2700

tga                                                                  2703


<210> 44
<211> 2703
<212> DNA
<213> artificial


<220> 
<223> sp7+hGAAco2-delta-43

<400> 44
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccatcct      60

ggtagaccaa gagctgtgcc tacccaatgc gacgtgccac ccaactcccg attcgactgc     120

gcgccagata aggctattac ccaagagcag tgtgaagcca gaggttgctg ctacatccca     180

gcgaagcaag gattgcaagg cgcccaaatg ggacaacctt ggtgtttctt ccccccttcg     240

tacccatcat ataaactcga aaacctgtcc tcttcggaaa tgggttatac tgccaccctc     300

accagaacta ctcctacttt cttcccgaaa gacatcttga ccttgaggct ggacgtgatg     360

atggagactg aaaaccggct gcatttcact atcaaagatc ctgccaatcg gcgatacgag     420

gtccctctgg aaacccctca cgtgcactca cgggctcctt ctccgcttta ctccgtcgaa     480

ttctctgagg aacccttcgg agtgatcgtt agacgccagc tggatggtag agtgctgttg     540

aacactactg tggccccact tttcttcgct gaccagtttc tgcaactgtc cacttccctg     600

ccatcccagt acattactgg actcgccgaa cacctgtcgc cactgatgct ctcgacctct     660

tggactagaa tcactttgtg gaacagagac ttggccccta ctccgggagc aaatctgtac     720

ggaagccacc ctttttacct ggcgctcgaa gatggcggat ccgctcacgg agtgttcctg     780

ctgaatagca acgcaatgga cgtggtgctg caaccttccc ctgcactcag ttggagaagt     840

accgggggta ttctggacgt gtacatcttc ctcggaccag aacccaagag cgtggtgcag     900

caatatctgg acgtggtcgg ataccctttt atgcctcctt actggggact gggattccac     960

ctttgccgtt ggggctactc atccaccgcc attaccagac aggtggtgga gaatatgacc    1020

agagcccact tccctctcga cgtgcagtgg aacgatctgg actatatgga ctcccggaga    1080

gatttcacct tcaacaagga cgggttccgc gattttcccg cgatggttca agagctccac    1140

cagggtggtc gaagatatat gatgatcgtc gacccagcca tttcgagcag cggacccgct    1200

ggatcttata gaccttacga cgaaggcctt aggagaggag tgttcatcac aaacgagact    1260

ggacagcctt tgatcggtaa agtgtggcct ggatcaaccg cctttcctga ctttaccaat    1320

cccactgcct tggcttggtg ggaggacatg gtggccgaat tccacgacca agtccccttt    1380

gatggaatgt ggatcgatat gaacgaacca agcaatttta tcagaggttc cgaagacggt    1440

tgccccaaca acgaactgga aaaccctcct tatgtgcccg gagtcgtggg cggaacatta    1500

caggccgcga ctatttgcgc cagcagccac caattcctgt ccactcacta caacctccac    1560

aacctttatg gattaaccga agctattgca agtcacaggg ctctggtgaa ggctagaggg    1620

actaggccct ttgtgatctc ccgatccacc tttgccggac acgggagata cgccggtcac    1680

tggactggtg acgtgtggag ctcatgggaa caactggcct cctccgtgcc ggaaatctta    1740

cagttcaacc ttctgggtgt ccctcttgtc ggagcagacg tgtgtgggtt tcttggtaac    1800

acctccgagg aactgtgtgt gcgctggact caactgggtg cattctaccc attcatgaga    1860

aaccacaact ccttgctgtc cctgccacaa gagccctact cgttcagcga gcctgcacaa    1920

caggctatgc ggaaggcact gaccctgaga tacgccctgc ttccacactt atacactctc    1980

ttccatcaag cgcatgtggc aggagaaacc gttgcaaggc ctcttttcct tgaattcccc    2040

aaggattcct cgacttggac ggtggatcat cagctgctgt ggggagaagc tctgctgatt    2100

actccagtgt tgcaagccgg aaaagctgag gtgaccggat actttccgct gggaacctgg    2160

tacgacctcc agactgtccc tgttgaagcc cttggatcac tgcctccgcc tccggcagct    2220

ccacgcgaac cagctataca ttccgaggga cagtgggtta cattaccagc tcctctggac    2280

acaatcaacg tccacttaag agctggctac attatccctc tgcaaggacc aggactgact    2340

acgaccgaga gcagacagca gccaatggca ctggctgtgg ctctgaccaa gggaggggaa    2400

gctagaggag aactcttctg ggatgatggg gagtcccttg aagtgctgga aagaggcgct    2460

tacactcaag tcattttcct tgcacggaac aacaccattg tgaacgaatt ggtgcgagtg    2520

accagcgaag gagctggact tcaactgcag aaggtcactg tgctcggagt ggctaccgct    2580

cctcagcaag tgctgtcgaa tggagtcccc gtgtcaaact ttacctactc ccctgacact    2640

aaggtgctcg acatttgcgt gtccctcctg atgggagagc agttccttgt gtcctggtgt    2700

tga                                                                  2703


<210> 45
<211> 2691
<212> DNA
<213> artificial


<220> 
<223> sp7+hGAAwt-delta-47

<400> 45
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggcccgcga      60

gcagtgccca cacagtgcga cgtccccccc aacagccgct tcgattgcgc ccctgacaag     120

gccatcaccc aggaacagtg cgaggcccgc ggctgttgct acatccctgc aaagcagggg     180

ctgcagggag cccagatggg gcagccctgg tgcttcttcc cacccagcta ccccagctac     240

aagctggaga acctgagctc ctctgaaatg ggctacacgg ccaccctgac ccgtaccacc     300

cccaccttct tccccaagga catcctgacc ctgcggctgg acgtgatgat ggagactgag     360

aaccgcctcc acttcacgat caaagatcca gctaacaggc gctacgaggt gcccttggag     420

accccgcatg tccacagccg ggcaccgtcc ccactctaca gcgtggagtt ctccgaggag     480

cccttcgggg tgatcgtgcg ccggcagctg gacggccgcg tgctgctgaa cacgacggtg     540

gcgcccctgt tctttgcgga ccagttcctt cagctgtcca cctcgctgcc ctcgcagtat     600

atcacaggcc tcgccgagca cctcagtccc ctgatgctca gcaccagctg gaccaggatc     660

accctgtgga accgggacct tgcgcccacg cccggtgcga acctctacgg gtctcaccct     720

ttctacctgg cgctggagga cggcgggtcg gcacacgggg tgttcctgct aaacagcaat     780

gccatggatg tggtcctgca gccgagccct gcccttagct ggaggtcgac aggtgggatc     840

ctggatgtct acatcttcct gggcccagag cccaagagcg tggtgcagca gtacctggac     900

gttgtgggat acccgttcat gccgccatac tggggcctgg gcttccacct gtgccgctgg     960

ggctactcct ccaccgctat cacccgccag gtggtggaga acatgaccag ggcccacttc    1020

cccctggacg tccagtggaa cgacctggac tacatggact cccggaggga cttcacgttc    1080

aacaaggatg gcttccggga cttcccggcc atggtgcagg agctgcacca gggcggccgg    1140

cgctacatga tgatcgtgga tcctgccatc agcagctcgg gccctgccgg gagctacagg    1200

ccctacgacg agggtctgcg gaggggggtt ttcatcacca acgagaccgg ccagccgctg    1260

attgggaagg tatggcccgg gtccactgcc ttccccgact tcaccaaccc cacagccctg    1320

gcctggtggg aggacatggt ggctgagttc catgaccagg tgcccttcga cggcatgtgg    1380

attgacatga acgagccttc caacttcatc aggggctctg aggacggctg ccccaacaat    1440

gagctggaga acccacccta cgtgcctggg gtggttgggg ggaccctcca ggcggccacc    1500

atctgtgcct ccagccacca gtttctctcc acacactaca acctgcacaa cctctacggc    1560

ctgaccgaag ccatcgcctc ccacagggcg ctggtgaagg ctcgggggac acgcccattt    1620

gtgatctccc gctcgacctt tgctggccac ggccgatacg ccggccactg gacgggggac    1680

gtgtggagct cctgggagca gctcgcctcc tccgtgccag aaatcctgca gtttaacctg    1740

ctgggggtgc ctctggtcgg ggccgacgtc tgcggcttcc tgggcaacac ctcagaggag    1800

ctgtgtgtgc gctggaccca gctgggggcc ttctacccct tcatgcggaa ccacaacagc    1860

ctgctcagtc tgccccagga gccgtacagc ttcagcgagc cggcccagca ggccatgagg    1920

aaggccctca ccctgcgcta cgcactcctc ccccacctct acacactgtt ccaccaggcc    1980

cacgtcgcgg gggagaccgt ggcccggccc ctcttcctgg agttccccaa ggactctagc    2040

acctggactg tggaccacca gctcctgtgg ggggaggccc tgctcatcac cccagtgctc    2100

caggccggga aggccgaagt gactggctac ttccccttgg gcacatggta cgacctgcag    2160

acggtgccag tagaggccct tggcagcctc ccacccccac ctgcagctcc ccgtgagcca    2220

gccatccaca gcgaggggca gtgggtgacg ctgccggccc ccctggacac catcaacgtc    2280

cacctccggg ctgggtacat catccccctg cagggccctg gcctcacaac cacagagtcc    2340

cgccagcagc ccatggccct ggctgtggcc ctgaccaagg gtggggaggc ccgaggggag    2400

ctgttctggg acgatggaga gagcctggaa gtgctggagc gaggggccta cacacaggtc    2460

atcttcctgg ccaggaataa cacgatcgtg aatgagctgg tacgtgtgac cagtgaggga    2520

gctggcctgc agctgcagaa ggtgactgtc ctgggcgtgg ccacggcgcc ccagcaggtc    2580

ctctccaacg gtgtccctgt ctccaacttc acctacagcc ccgacaccaa ggtcctggac    2640

atctgtgtct cgctgttgat gggagagcag tttctcgtca gctggtgtta g             2691


<210> 46
<211> 2691
<212> DNA
<213> artificial


<220> 
<223> sp7+hGAAco1-delta-47

<400> 46
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccctaga      60

gctgtgccta cccagtgtga cgtgcccccc aacagcagat tcgactgcgc ccctgacaag     120

gccatcaccc aggaacagtg cgaggccaga ggctgctgct acatccctgc caagcaggga     180

ctgcagggcg ctcagatggg acagccctgg tgcttcttcc caccctccta ccccagctac     240

aagctggaaa acctgagcag cagcgagatg ggctacaccg ccaccctgac cagaaccacc     300

cccacattct tcccaaagga catcctgacc ctgcggctgg acgtgatgat ggaaaccgag     360

aaccggctgc acttcaccat caaggacccc gccaatcgga gatacgaggt gcccctggaa     420

accccccacg tgcactctag agcccccagc cctctgtaca gcgtggaatt cagcgaggaa     480

cccttcggcg tgatcgtgcg gagacagctg gatggcagag tgctgctgaa caccaccgtg     540

gcccctctgt tcttcgccga ccagttcctg cagctgagca ccagcctgcc cagccagtac     600

atcacaggac tggccgagca cctgagcccc ctgatgctga gcacatcctg gacccggatc     660

accctgtgga acagggatct ggcccctacc cctggcgcca atctgtacgg cagccaccct     720

ttctacctgg ccctggaaga tggcggatct gcccacggag tgtttctgct gaactccaac     780

gccatggacg tggtgctgca gcctagccct gccctgtctt ggagaagcac aggcggcatc     840

ctggatgtgt acatctttct gggccccgag cccaagagcg tggtgcagca gtatctggat     900

gtcgtgggct accccttcat gcccccttac tggggcctgg gattccacct gtgcagatgg     960

ggctactcca gcaccgccat caccagacag gtggtggaaa acatgaccag agcccacttc    1020

ccactggatg tgcagtggaa cgacctggac tacatggaca gcagacggga cttcaccttc    1080

aacaaggacg gcttccggga cttccccgcc atggtgcagg aactgcatca gggcggcaga    1140

cggtacatga tgatcgtgga tcccgccatc agctcctctg gccctgccgg ctcttacaga    1200

ccctacgacg agggcctgcg gagaggcgtg ttcatcacca acgagacagg ccagcccctg    1260

atcggcaaag tgtggcctgg cagcacagcc ttccccgact tcaccaatcc taccgccctg    1320

gcttggtggg aggacatggt ggccgagttc cacgaccagg tgcccttcga cggcatgtgg    1380

atcgacatga acgagcccag caacttcatc cggggcagcg aggatggctg ccccaacaac    1440

gaactggaaa atccccctta cgtgcccggc gtcgtgggcg gaacactgca ggccgctaca    1500

atctgtgcca gcagccacca gtttctgagc acccactaca acctgcacaa cctgtacggc    1560

ctgaccgagg ccattgccag ccaccgcgct ctcgtgaaag ccagaggcac acggcccttc    1620

gtgatcagca gaagcacctt tgccggccac ggcagatacg ccggacattg gactggcgac    1680

gtgtggtcct cttgggagca gctggcctct agcgtgcccg agatcctgca gttcaatctg    1740

ctgggcgtgc cactcgtggg cgccgatgtg tgtggcttcc tgggcaacac ctccgaggaa    1800

ctgtgtgtgc ggtggacaca gctgggcgcc ttctaccctt tcatgagaaa ccacaacagc    1860

ctgctgagcc tgccccagga accctacagc tttagcgagc ctgcacagca ggccatgcgg    1920

aaggccctga cactgagata cgctctgctg ccccacctgt acaccctgtt tcaccaggcc    1980

catgtggccg gcgagacagt ggccagacct ctgtttctgg aattccccaa ggacagcagc    2040

acctggaccg tggaccatca gctgctgtgg ggagaggctc tgctgattac cccagtgctg    2100

caggcaggca aggccgaagt gaccggctac tttcccctgg gcacttggta cgacctgcag    2160

accgtgcctg tggaagccct gggatctctg cctccacctc ctgccgctcc tagagagcct    2220

gccattcact ctgagggcca gtgggtcaca ctgcctgccc ccctggatac catcaacgtg    2280

cacctgaggg ccggctacat cataccactg cagggacctg gcctgaccac caccgagtct    2340

agacagcagc caatggccct ggccgtggcc ctgaccaaag gcggagaagc taggggcgag    2400

ctgttctggg acgatggcga gagcctggaa gtgctggaaa gaggcgccta tacccaagtg    2460

atcttcctgg cccggaacaa caccatcgtg aacgagctgg tgcgcgtgac ctctgaaggc    2520

gctggactgc agctgcagaa agtgaccgtg ctgggagtgg ccacagcccc tcagcaggtg    2580

ctgtctaatg gcgtgcccgt gtccaacttc acctacagcc ccgacaccaa ggtgctggac    2640

atctgcgtgt cactgctgat gggagagcag tttctggtgt cctggtgctg a             2691


<210> 47
<211> 2691
<212> DNA
<213> artificial


<220> 
<223> sp7+hGAAco2-delta-47

<400> 47
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggcccaaga      60

gctgtgccta cccaatgcga cgtgccaccc aactcccgat tcgactgcgc gccagataag     120

gctattaccc aagagcagtg tgaagccaga ggttgctgct acatcccagc gaagcaagga     180

ttgcaaggcg cccaaatggg acaaccttgg tgtttcttcc ccccttcgta cccatcatat     240

aaactcgaaa acctgtcctc ttcggaaatg ggttatactg ccaccctcac cagaactact     300

cctactttct tcccgaaaga catcttgacc ttgaggctgg acgtgatgat ggagactgaa     360

aaccggctgc atttcactat caaagatcct gccaatcggc gatacgaggt ccctctggaa     420

acccctcacg tgcactcacg ggctccttct ccgctttact ccgtcgaatt ctctgaggaa     480

cccttcggag tgatcgttag acgccagctg gatggtagag tgctgttgaa cactactgtg     540

gccccacttt tcttcgctga ccagtttctg caactgtcca cttccctgcc atcccagtac     600

attactggac tcgccgaaca cctgtcgcca ctgatgctct cgacctcttg gactagaatc     660

actttgtgga acagagactt ggcccctact ccgggagcaa atctgtacgg aagccaccct     720

ttttacctgg cgctcgaaga tggcggatcc gctcacggag tgttcctgct gaatagcaac     780

gcaatggacg tggtgctgca accttcccct gcactcagtt ggagaagtac cgggggtatt     840

ctggacgtgt acatcttcct cggaccagaa cccaagagcg tggtgcagca atatctggac     900

gtggtcggat acccttttat gcctccttac tggggactgg gattccacct ttgccgttgg     960

ggctactcat ccaccgccat taccagacag gtggtggaga atatgaccag agcccacttc    1020

cctctcgacg tgcagtggaa cgatctggac tatatggact cccggagaga tttcaccttc    1080

aacaaggacg ggttccgcga ttttcccgcg atggttcaag agctccacca gggtggtcga    1140

agatatatga tgatcgtcga cccagccatt tcgagcagcg gacccgctgg atcttataga    1200

ccttacgacg aaggccttag gagaggagtg ttcatcacaa acgagactgg acagcctttg    1260

atcggtaaag tgtggcctgg atcaaccgcc tttcctgact ttaccaatcc cactgccttg    1320

gcttggtggg aggacatggt ggccgaattc cacgaccaag tcccctttga tggaatgtgg    1380

atcgatatga acgaaccaag caattttatc agaggttccg aagacggttg ccccaacaac    1440

gaactggaaa accctcctta tgtgcccgga gtcgtgggcg gaacattaca ggccgcgact    1500

atttgcgcca gcagccacca attcctgtcc actcactaca acctccacaa cctttatgga    1560

ttaaccgaag ctattgcaag tcacagggct ctggtgaagg ctagagggac taggcccttt    1620

gtgatctccc gatccacctt tgccggacac gggagatacg ccggtcactg gactggtgac    1680

gtgtggagct catgggaaca actggcctcc tccgtgccgg aaatcttaca gttcaacctt    1740

ctgggtgtcc ctcttgtcgg agcagacgtg tgtgggtttc ttggtaacac ctccgaggaa    1800

ctgtgtgtgc gctggactca actgggtgca ttctacccat tcatgagaaa ccacaactcc    1860

ttgctgtccc tgccacaaga gccctactcg ttcagcgagc ctgcacaaca ggctatgcgg    1920

aaggcactga ccctgagata cgccctgctt ccacacttat acactctctt ccatcaagcg    1980

catgtggcag gagaaaccgt tgcaaggcct cttttccttg aattccccaa ggattcctcg    2040

acttggacgg tggatcatca gctgctgtgg ggagaagctc tgctgattac tccagtgttg    2100

caagccggaa aagctgaggt gaccggatac tttccgctgg gaacctggta cgacctccag    2160

actgtccctg ttgaagccct tggatcactg cctccgcctc cggcagctcc acgcgaacca    2220

gctatacatt ccgagggaca gtgggttaca ttaccagctc ctctggacac aatcaacgtc    2280

cacttaagag ctggctacat tatccctctg caaggaccag gactgactac gaccgagagc    2340

agacagcagc caatggcact ggctgtggct ctgaccaagg gaggggaagc tagaggagaa    2400

ctcttctggg atgatgggga gtcccttgaa gtgctggaaa gaggcgctta cactcaagtc    2460

attttccttg cacggaacaa caccattgtg aacgaattgg tgcgagtgac cagcgaagga    2520

gctggacttc aactgcagaa ggtcactgtg ctcggagtgg ctaccgctcc tcagcaagtg    2580

ctgtcgaatg gagtccccgt gtcaaacttt acctactccc ctgacactaa ggtgctcgac    2640

atttgcgtgt ccctcctgat gggagagcag ttccttgtgt cctggtgttg a             2691


<210> 48
<211> 2652
<212> DNA
<213> artificial


<220> 
<223> hGAAco1-delta-42

<400> 48
gcccaccccg gcagacctag agctgtgcct acccagtgtg acgtgccccc caacagcaga      60

ttcgactgcg cccctgacaa ggccatcacc caggaacagt gcgaggccag aggctgctgc     120

tacatccctg ccaagcaggg actgcagggc gctcagatgg gacagccctg gtgcttcttc     180

ccaccctcct accccagcta caagctggaa aacctgagca gcagcgagat gggctacacc     240

gccaccctga ccagaaccac ccccacattc ttcccaaagg acatcctgac cctgcggctg     300

gacgtgatga tggaaaccga gaaccggctg cacttcacca tcaaggaccc cgccaatcgg     360

agatacgagg tgcccctgga aaccccccac gtgcactcta gagcccccag ccctctgtac     420

agcgtggaat tcagcgagga acccttcggc gtgatcgtgc ggagacagct ggatggcaga     480

gtgctgctga acaccaccgt ggcccctctg ttcttcgccg accagttcct gcagctgagc     540

accagcctgc ccagccagta catcacagga ctggccgagc acctgagccc cctgatgctg     600

agcacatcct ggacccggat caccctgtgg aacagggatc tggcccctac ccctggcgcc     660

aatctgtacg gcagccaccc tttctacctg gccctggaag atggcggatc tgcccacgga     720

gtgtttctgc tgaactccaa cgccatggac gtggtgctgc agcctagccc tgccctgtct     780

tggagaagca caggcggcat cctggatgtg tacatctttc tgggccccga gcccaagagc     840

gtggtgcagc agtatctgga tgtcgtgggc taccccttca tgccccctta ctggggcctg     900

ggattccacc tgtgcagatg gggctactcc agcaccgcca tcaccagaca ggtggtggaa     960

aacatgacca gagcccactt cccactggat gtgcagtgga acgacctgga ctacatggac    1020

agcagacggg acttcacctt caacaaggac ggcttccggg acttccccgc catggtgcag    1080

gaactgcatc agggcggcag acggtacatg atgatcgtgg atcccgccat cagctcctct    1140

ggccctgccg gctcttacag accctacgac gagggcctgc ggagaggcgt gttcatcacc    1200

aacgagacag gccagcccct gatcggcaaa gtgtggcctg gcagcacagc cttccccgac    1260

ttcaccaatc ctaccgccct ggcttggtgg gaggacatgg tggccgagtt ccacgaccag    1320

gtgcccttcg acggcatgtg gatcgacatg aacgagccca gcaacttcat ccggggcagc    1380

gaggatggct gccccaacaa cgaactggaa aatccccctt acgtgcccgg cgtcgtgggc    1440

ggaacactgc aggccgctac aatctgtgcc agcagccacc agtttctgag cacccactac    1500

aacctgcaca acctgtacgg cctgaccgag gccattgcca gccaccgcgc tctcgtgaaa    1560

gccagaggca cacggccctt cgtgatcagc agaagcacct ttgccggcca cggcagatac    1620

gccggacatt ggactggcga cgtgtggtcc tcttgggagc agctggcctc tagcgtgccc    1680

gagatcctgc agttcaatct gctgggcgtg ccactcgtgg gcgccgatgt gtgtggcttc    1740

ctgggcaaca cctccgagga actgtgtgtg cggtggacac agctgggcgc cttctaccct    1800

ttcatgagaa accacaacag cctgctgagc ctgccccagg aaccctacag ctttagcgag    1860

cctgcacagc aggccatgcg gaaggccctg acactgagat acgctctgct gccccacctg    1920

tacaccctgt ttcaccaggc ccatgtggcc ggcgagacag tggccagacc tctgtttctg    1980

gaattcccca aggacagcag cacctggacc gtggaccatc agctgctgtg gggagaggct    2040

ctgctgatta ccccagtgct gcaggcaggc aaggccgaag tgaccggcta ctttcccctg    2100

ggcacttggt acgacctgca gaccgtgcct gtggaagccc tgggatctct gcctccacct    2160

cctgccgctc ctagagagcc tgccattcac tctgagggcc agtgggtcac actgcctgcc    2220

cccctggata ccatcaacgt gcacctgagg gccggctaca tcataccact gcagggacct    2280

ggcctgacca ccaccgagtc tagacagcag ccaatggccc tggccgtggc cctgaccaaa    2340

ggcggagaag ctaggggcga gctgttctgg gacgatggcg agagcctgga agtgctggaa    2400

agaggcgcct atacccaagt gatcttcctg gcccggaaca acaccatcgt gaacgagctg    2460

gtgcgcgtga cctctgaagg cgctggactg cagctgcaga aagtgaccgt gctgggagtg    2520

gccacagccc ctcagcaggt gctgtctaat ggcgtgcccg tgtccaactt cacctacagc    2580

cccgacacca aggtgctgga catctgcgtg tcactgctga tgggagagca gtttctggtg    2640

tcctggtgct ga                                                        2652


<210> 49
<211> 2652
<212> DNA
<213> artificial


<220> 
<223> hGAAco2-delta-42

<400> 49
gcccatcctg gtagaccaag agctgtgcct acccaatgcg acgtgccacc caactcccga      60

ttcgactgcg cgccagataa ggctattacc caagagcagt gtgaagccag aggttgctgc     120

tacatcccag cgaagcaagg attgcaaggc gcccaaatgg gacaaccttg gtgtttcttc     180

cccccttcgt acccatcata taaactcgaa aacctgtcct cttcggaaat gggttatact     240

gccaccctca ccagaactac tcctactttc ttcccgaaag acatcttgac cttgaggctg     300

gacgtgatga tggagactga aaaccggctg catttcacta tcaaagatcc tgccaatcgg     360

cgatacgagg tccctctgga aacccctcac gtgcactcac gggctccttc tccgctttac     420

tccgtcgaat tctctgagga acccttcgga gtgatcgtta gacgccagct ggatggtaga     480

gtgctgttga acactactgt ggccccactt ttcttcgctg accagtttct gcaactgtcc     540

acttccctgc catcccagta cattactgga ctcgccgaac acctgtcgcc actgatgctc     600

tcgacctctt ggactagaat cactttgtgg aacagagact tggcccctac tccgggagca     660

aatctgtacg gaagccaccc tttttacctg gcgctcgaag atggcggatc cgctcacgga     720

gtgttcctgc tgaatagcaa cgcaatggac gtggtgctgc aaccttcccc tgcactcagt     780

tggagaagta ccgggggtat tctggacgtg tacatcttcc tcggaccaga acccaagagc     840

gtggtgcagc aatatctgga cgtggtcgga taccctttta tgcctcctta ctggggactg     900

ggattccacc tttgccgttg gggctactca tccaccgcca ttaccagaca ggtggtggag     960

aatatgacca gagcccactt ccctctcgac gtgcagtgga acgatctgga ctatatggac    1020

tcccggagag atttcacctt caacaaggac gggttccgcg attttcccgc gatggttcaa    1080

gagctccacc agggtggtcg aagatatatg atgatcgtcg acccagccat ttcgagcagc    1140

ggacccgctg gatcttatag accttacgac gaaggcctta ggagaggagt gttcatcaca    1200

aacgagactg gacagccttt gatcggtaaa gtgtggcctg gatcaaccgc ctttcctgac    1260

tttaccaatc ccactgcctt ggcttggtgg gaggacatgg tggccgaatt ccacgaccaa    1320

gtcccctttg atggaatgtg gatcgatatg aacgaaccaa gcaattttat cagaggttcc    1380

gaagacggtt gccccaacaa cgaactggaa aaccctcctt atgtgcccgg agtcgtgggc    1440

ggaacattac aggccgcgac tatttgcgcc agcagccacc aattcctgtc cactcactac    1500

aacctccaca acctttatgg attaaccgaa gctattgcaa gtcacagggc tctggtgaag    1560

gctagaggga ctaggccctt tgtgatctcc cgatccacct ttgccggaca cgggagatac    1620

gccggtcact ggactggtga cgtgtggagc tcatgggaac aactggcctc ctccgtgccg    1680

gaaatcttac agttcaacct tctgggtgtc cctcttgtcg gagcagacgt gtgtgggttt    1740

cttggtaaca cctccgagga actgtgtgtg cgctggactc aactgggtgc attctaccca    1800

ttcatgagaa accacaactc cttgctgtcc ctgccacaag agccctactc gttcagcgag    1860

cctgcacaac aggctatgcg gaaggcactg accctgagat acgccctgct tccacactta    1920

tacactctct tccatcaagc gcatgtggca ggagaaaccg ttgcaaggcc tcttttcctt    1980

gaattcccca aggattcctc gacttggacg gtggatcatc agctgctgtg gggagaagct    2040

ctgctgatta ctccagtgtt gcaagccgga aaagctgagg tgaccggata ctttccgctg    2100

ggaacctggt acgacctcca gactgtccct gttgaagccc ttggatcact gcctccgcct    2160

ccggcagctc cacgcgaacc agctatacat tccgagggac agtgggttac attaccagct    2220

cctctggaca caatcaacgt ccacttaaga gctggctaca ttatccctct gcaaggacca    2280

ggactgacta cgaccgagag cagacagcag ccaatggcac tggctgtggc tctgaccaag    2340

ggaggggaag ctagaggaga actcttctgg gatgatgggg agtcccttga agtgctggaa    2400

agaggcgctt acactcaagt cattttcctt gcacggaaca acaccattgt gaacgaattg    2460

gtgcgagtga ccagcgaagg agctggactt caactgcaga aggtcactgt gctcggagtg    2520

gctaccgctc ctcagcaagt gctgtcgaat ggagtccccg tgtcaaactt tacctactcc    2580

cctgacacta aggtgctcga catttgcgtg tccctcctga tgggagagca gttccttgtg    2640

tcctggtgtt ga                                                        2652


<210> 50
<211> 2649
<212> DNA
<213> artificial


<220> 
<223> hGAAco1-delta-43

<400> 50
caccccggca gacctagagc tgtgcctacc cagtgtgacg tgccccccaa cagcagattc      60

gactgcgccc ctgacaaggc catcacccag gaacagtgcg aggccagagg ctgctgctac     120

atccctgcca agcagggact gcagggcgct cagatgggac agccctggtg cttcttccca     180

ccctcctacc ccagctacaa gctggaaaac ctgagcagca gcgagatggg ctacaccgcc     240

accctgacca gaaccacccc cacattcttc ccaaaggaca tcctgaccct gcggctggac     300

gtgatgatgg aaaccgagaa ccggctgcac ttcaccatca aggaccccgc caatcggaga     360

tacgaggtgc ccctggaaac cccccacgtg cactctagag cccccagccc tctgtacagc     420

gtggaattca gcgaggaacc cttcggcgtg atcgtgcgga gacagctgga tggcagagtg     480

ctgctgaaca ccaccgtggc ccctctgttc ttcgccgacc agttcctgca gctgagcacc     540

agcctgccca gccagtacat cacaggactg gccgagcacc tgagccccct gatgctgagc     600

acatcctgga cccggatcac cctgtggaac agggatctgg cccctacccc tggcgccaat     660

ctgtacggca gccacccttt ctacctggcc ctggaagatg gcggatctgc ccacggagtg     720

tttctgctga actccaacgc catggacgtg gtgctgcagc ctagccctgc cctgtcttgg     780

agaagcacag gcggcatcct ggatgtgtac atctttctgg gccccgagcc caagagcgtg     840

gtgcagcagt atctggatgt cgtgggctac cccttcatgc ccccttactg gggcctggga     900

ttccacctgt gcagatgggg ctactccagc accgccatca ccagacaggt ggtggaaaac     960

atgaccagag cccacttccc actggatgtg cagtggaacg acctggacta catggacagc    1020

agacgggact tcaccttcaa caaggacggc ttccgggact tccccgccat ggtgcaggaa    1080

ctgcatcagg gcggcagacg gtacatgatg atcgtggatc ccgccatcag ctcctctggc    1140

cctgccggct cttacagacc ctacgacgag ggcctgcgga gaggcgtgtt catcaccaac    1200

gagacaggcc agcccctgat cggcaaagtg tggcctggca gcacagcctt ccccgacttc    1260

accaatccta ccgccctggc ttggtgggag gacatggtgg ccgagttcca cgaccaggtg    1320

cccttcgacg gcatgtggat cgacatgaac gagcccagca acttcatccg gggcagcgag    1380

gatggctgcc ccaacaacga actggaaaat cccccttacg tgcccggcgt cgtgggcgga    1440

acactgcagg ccgctacaat ctgtgccagc agccaccagt ttctgagcac ccactacaac    1500

ctgcacaacc tgtacggcct gaccgaggcc attgccagcc accgcgctct cgtgaaagcc    1560

agaggcacac ggcccttcgt gatcagcaga agcacctttg ccggccacgg cagatacgcc    1620

ggacattgga ctggcgacgt gtggtcctct tgggagcagc tggcctctag cgtgcccgag    1680

atcctgcagt tcaatctgct gggcgtgcca ctcgtgggcg ccgatgtgtg tggcttcctg    1740

ggcaacacct ccgaggaact gtgtgtgcgg tggacacagc tgggcgcctt ctaccctttc    1800

atgagaaacc acaacagcct gctgagcctg ccccaggaac cctacagctt tagcgagcct    1860

gcacagcagg ccatgcggaa ggccctgaca ctgagatacg ctctgctgcc ccacctgtac    1920

accctgtttc accaggccca tgtggccggc gagacagtgg ccagacctct gtttctggaa    1980

ttccccaagg acagcagcac ctggaccgtg gaccatcagc tgctgtgggg agaggctctg    2040

ctgattaccc cagtgctgca ggcaggcaag gccgaagtga ccggctactt tcccctgggc    2100

acttggtacg acctgcagac cgtgcctgtg gaagccctgg gatctctgcc tccacctcct    2160

gccgctccta gagagcctgc cattcactct gagggccagt gggtcacact gcctgccccc    2220

ctggatacca tcaacgtgca cctgagggcc ggctacatca taccactgca gggacctggc    2280

ctgaccacca ccgagtctag acagcagcca atggccctgg ccgtggccct gaccaaaggc    2340

ggagaagcta ggggcgagct gttctgggac gatggcgaga gcctggaagt gctggaaaga    2400

ggcgcctata cccaagtgat cttcctggcc cggaacaaca ccatcgtgaa cgagctggtg    2460

cgcgtgacct ctgaaggcgc tggactgcag ctgcagaaag tgaccgtgct gggagtggcc    2520

acagcccctc agcaggtgct gtctaatggc gtgcccgtgt ccaacttcac ctacagcccc    2580

gacaccaagg tgctggacat ctgcgtgtca ctgctgatgg gagagcagtt tctggtgtcc    2640

tggtgctga                                                            2649


<210> 51
<211> 2649
<212> DNA
<213> artificial


<220> 
<223> hGAAco2-delta-43

<400> 51
catcctggta gaccaagagc tgtgcctacc caatgcgacg tgccacccaa ctcccgattc      60

gactgcgcgc cagataaggc tattacccaa gagcagtgtg aagccagagg ttgctgctac     120

atcccagcga agcaaggatt gcaaggcgcc caaatgggac aaccttggtg tttcttcccc     180

ccttcgtacc catcatataa actcgaaaac ctgtcctctt cggaaatggg ttatactgcc     240

accctcacca gaactactcc tactttcttc ccgaaagaca tcttgacctt gaggctggac     300

gtgatgatgg agactgaaaa ccggctgcat ttcactatca aagatcctgc caatcggcga     360

tacgaggtcc ctctggaaac ccctcacgtg cactcacggg ctccttctcc gctttactcc     420

gtcgaattct ctgaggaacc cttcggagtg atcgttagac gccagctgga tggtagagtg     480

ctgttgaaca ctactgtggc cccacttttc ttcgctgacc agtttctgca actgtccact     540

tccctgccat cccagtacat tactggactc gccgaacacc tgtcgccact gatgctctcg     600

acctcttgga ctagaatcac tttgtggaac agagacttgg cccctactcc gggagcaaat     660

ctgtacggaa gccacccttt ttacctggcg ctcgaagatg gcggatccgc tcacggagtg     720

ttcctgctga atagcaacgc aatggacgtg gtgctgcaac cttcccctgc actcagttgg     780

agaagtaccg ggggtattct ggacgtgtac atcttcctcg gaccagaacc caagagcgtg     840

gtgcagcaat atctggacgt ggtcggatac ccttttatgc ctccttactg gggactggga     900

ttccaccttt gccgttgggg ctactcatcc accgccatta ccagacaggt ggtggagaat     960

atgaccagag cccacttccc tctcgacgtg cagtggaacg atctggacta tatggactcc    1020

cggagagatt tcaccttcaa caaggacggg ttccgcgatt ttcccgcgat ggttcaagag    1080

ctccaccagg gtggtcgaag atatatgatg atcgtcgacc cagccatttc gagcagcgga    1140

cccgctggat cttatagacc ttacgacgaa ggccttagga gaggagtgtt catcacaaac    1200

gagactggac agcctttgat cggtaaagtg tggcctggat caaccgcctt tcctgacttt    1260

accaatccca ctgccttggc ttggtgggag gacatggtgg ccgaattcca cgaccaagtc    1320

ccctttgatg gaatgtggat cgatatgaac gaaccaagca attttatcag aggttccgaa    1380

gacggttgcc ccaacaacga actggaaaac cctccttatg tgcccggagt cgtgggcgga    1440

acattacagg ccgcgactat ttgcgccagc agccaccaat tcctgtccac tcactacaac    1500

ctccacaacc tttatggatt aaccgaagct attgcaagtc acagggctct ggtgaaggct    1560

agagggacta ggccctttgt gatctcccga tccacctttg ccggacacgg gagatacgcc    1620

ggtcactgga ctggtgacgt gtggagctca tgggaacaac tggcctcctc cgtgccggaa    1680

atcttacagt tcaaccttct gggtgtccct cttgtcggag cagacgtgtg tgggtttctt    1740

ggtaacacct ccgaggaact gtgtgtgcgc tggactcaac tgggtgcatt ctacccattc    1800

atgagaaacc acaactcctt gctgtccctg ccacaagagc cctactcgtt cagcgagcct    1860

gcacaacagg ctatgcggaa ggcactgacc ctgagatacg ccctgcttcc acacttatac    1920

actctcttcc atcaagcgca tgtggcagga gaaaccgttg caaggcctct tttccttgaa    1980

ttccccaagg attcctcgac ttggacggtg gatcatcagc tgctgtgggg agaagctctg    2040

ctgattactc cagtgttgca agccggaaaa gctgaggtga ccggatactt tccgctggga    2100

acctggtacg acctccagac tgtccctgtt gaagcccttg gatcactgcc tccgcctccg    2160

gcagctccac gcgaaccagc tatacattcc gagggacagt gggttacatt accagctcct    2220

ctggacacaa tcaacgtcca cttaagagct ggctacatta tccctctgca aggaccagga    2280

ctgactacga ccgagagcag acagcagcca atggcactgg ctgtggctct gaccaaggga    2340

ggggaagcta gaggagaact cttctgggat gatggggagt cccttgaagt gctggaaaga    2400

ggcgcttaca ctcaagtcat tttccttgca cggaacaaca ccattgtgaa cgaattggtg    2460

cgagtgacca gcgaaggagc tggacttcaa ctgcagaagg tcactgtgct cggagtggct    2520

accgctcctc agcaagtgct gtcgaatgga gtccccgtgt caaactttac ctactcccct    2580

gacactaagg tgctcgacat ttgcgtgtcc ctcctgatgg gagagcagtt ccttgtgtcc    2640

tggtgttga                                                            2649


<210> 52
<211> 2637
<212> DNA
<213> artificial


<220> 
<223> hGAAco1-delta-47

<400> 52
cctagagctg tgcctaccca gtgtgacgtg ccccccaaca gcagattcga ctgcgcccct      60

gacaaggcca tcacccagga acagtgcgag gccagaggct gctgctacat ccctgccaag     120

cagggactgc agggcgctca gatgggacag ccctggtgct tcttcccacc ctcctacccc     180

agctacaagc tggaaaacct gagcagcagc gagatgggct acaccgccac cctgaccaga     240

accaccccca cattcttccc aaaggacatc ctgaccctgc ggctggacgt gatgatggaa     300

accgagaacc ggctgcactt caccatcaag gaccccgcca atcggagata cgaggtgccc     360

ctggaaaccc cccacgtgca ctctagagcc cccagccctc tgtacagcgt ggaattcagc     420

gaggaaccct tcggcgtgat cgtgcggaga cagctggatg gcagagtgct gctgaacacc     480

accgtggccc ctctgttctt cgccgaccag ttcctgcagc tgagcaccag cctgcccagc     540

cagtacatca caggactggc cgagcacctg agccccctga tgctgagcac atcctggacc     600

cggatcaccc tgtggaacag ggatctggcc cctacccctg gcgccaatct gtacggcagc     660

caccctttct acctggccct ggaagatggc ggatctgccc acggagtgtt tctgctgaac     720

tccaacgcca tggacgtggt gctgcagcct agccctgccc tgtcttggag aagcacaggc     780

ggcatcctgg atgtgtacat ctttctgggc cccgagccca agagcgtggt gcagcagtat     840

ctggatgtcg tgggctaccc cttcatgccc ccttactggg gcctgggatt ccacctgtgc     900

agatggggct actccagcac cgccatcacc agacaggtgg tggaaaacat gaccagagcc     960

cacttcccac tggatgtgca gtggaacgac ctggactaca tggacagcag acgggacttc    1020

accttcaaca aggacggctt ccgggacttc cccgccatgg tgcaggaact gcatcagggc    1080

ggcagacggt acatgatgat cgtggatccc gccatcagct cctctggccc tgccggctct    1140

tacagaccct acgacgaggg cctgcggaga ggcgtgttca tcaccaacga gacaggccag    1200

cccctgatcg gcaaagtgtg gcctggcagc acagccttcc ccgacttcac caatcctacc    1260

gccctggctt ggtgggagga catggtggcc gagttccacg accaggtgcc cttcgacggc    1320

atgtggatcg acatgaacga gcccagcaac ttcatccggg gcagcgagga tggctgcccc    1380

aacaacgaac tggaaaatcc cccttacgtg cccggcgtcg tgggcggaac actgcaggcc    1440

gctacaatct gtgccagcag ccaccagttt ctgagcaccc actacaacct gcacaacctg    1500

tacggcctga ccgaggccat tgccagccac cgcgctctcg tgaaagccag aggcacacgg    1560

cccttcgtga tcagcagaag cacctttgcc ggccacggca gatacgccgg acattggact    1620

ggcgacgtgt ggtcctcttg ggagcagctg gcctctagcg tgcccgagat cctgcagttc    1680

aatctgctgg gcgtgccact cgtgggcgcc gatgtgtgtg gcttcctggg caacacctcc    1740

gaggaactgt gtgtgcggtg gacacagctg ggcgccttct accctttcat gagaaaccac    1800

aacagcctgc tgagcctgcc ccaggaaccc tacagcttta gcgagcctgc acagcaggcc    1860

atgcggaagg ccctgacact gagatacgct ctgctgcccc acctgtacac cctgtttcac    1920

caggcccatg tggccggcga gacagtggcc agacctctgt ttctggaatt ccccaaggac    1980

agcagcacct ggaccgtgga ccatcagctg ctgtggggag aggctctgct gattacccca    2040

gtgctgcagg caggcaaggc cgaagtgacc ggctactttc ccctgggcac ttggtacgac    2100

ctgcagaccg tgcctgtgga agccctggga tctctgcctc cacctcctgc cgctcctaga    2160

gagcctgcca ttcactctga gggccagtgg gtcacactgc ctgcccccct ggataccatc    2220

aacgtgcacc tgagggccgg ctacatcata ccactgcagg gacctggcct gaccaccacc    2280

gagtctagac agcagccaat ggccctggcc gtggccctga ccaaaggcgg agaagctagg    2340

ggcgagctgt tctgggacga tggcgagagc ctggaagtgc tggaaagagg cgcctatacc    2400

caagtgatct tcctggcccg gaacaacacc atcgtgaacg agctggtgcg cgtgacctct    2460

gaaggcgctg gactgcagct gcagaaagtg accgtgctgg gagtggccac agcccctcag    2520

caggtgctgt ctaatggcgt gcccgtgtcc aacttcacct acagccccga caccaaggtg    2580

ctggacatct gcgtgtcact gctgatggga gagcagtttc tggtgtcctg gtgctga       2637


<210> 53
<211> 2637
<212> DNA
<213> artificial


<220> 
<223> hGAAco2-delta-47

<400> 53
ccaagagctg tgcctaccca atgcgacgtg ccacccaact cccgattcga ctgcgcgcca      60

gataaggcta ttacccaaga gcagtgtgaa gccagaggtt gctgctacat cccagcgaag     120

caaggattgc aaggcgccca aatgggacaa ccttggtgtt tcttcccccc ttcgtaccca     180

tcatataaac tcgaaaacct gtcctcttcg gaaatgggtt atactgccac cctcaccaga     240

actactccta ctttcttccc gaaagacatc ttgaccttga ggctggacgt gatgatggag     300

actgaaaacc ggctgcattt cactatcaaa gatcctgcca atcggcgata cgaggtccct     360

ctggaaaccc ctcacgtgca ctcacgggct ccttctccgc tttactccgt cgaattctct     420

gaggaaccct tcggagtgat cgttagacgc cagctggatg gtagagtgct gttgaacact     480

actgtggccc cacttttctt cgctgaccag tttctgcaac tgtccacttc cctgccatcc     540

cagtacatta ctggactcgc cgaacacctg tcgccactga tgctctcgac ctcttggact     600

agaatcactt tgtggaacag agacttggcc cctactccgg gagcaaatct gtacggaagc     660

cacccttttt acctggcgct cgaagatggc ggatccgctc acggagtgtt cctgctgaat     720

agcaacgcaa tggacgtggt gctgcaacct tcccctgcac tcagttggag aagtaccggg     780

ggtattctgg acgtgtacat cttcctcgga ccagaaccca agagcgtggt gcagcaatat     840

ctggacgtgg tcggataccc ttttatgcct ccttactggg gactgggatt ccacctttgc     900

cgttggggct actcatccac cgccattacc agacaggtgg tggagaatat gaccagagcc     960

cacttccctc tcgacgtgca gtggaacgat ctggactata tggactcccg gagagatttc    1020

accttcaaca aggacgggtt ccgcgatttt cccgcgatgg ttcaagagct ccaccagggt    1080

ggtcgaagat atatgatgat cgtcgaccca gccatttcga gcagcggacc cgctggatct    1140

tatagacctt acgacgaagg ccttaggaga ggagtgttca tcacaaacga gactggacag    1200

cctttgatcg gtaaagtgtg gcctggatca accgcctttc ctgactttac caatcccact    1260

gccttggctt ggtgggagga catggtggcc gaattccacg accaagtccc ctttgatgga    1320

atgtggatcg atatgaacga accaagcaat tttatcagag gttccgaaga cggttgcccc    1380

aacaacgaac tggaaaaccc tccttatgtg cccggagtcg tgggcggaac attacaggcc    1440

gcgactattt gcgccagcag ccaccaattc ctgtccactc actacaacct ccacaacctt    1500

tatggattaa ccgaagctat tgcaagtcac agggctctgg tgaaggctag agggactagg    1560

ccctttgtga tctcccgatc cacctttgcc ggacacggga gatacgccgg tcactggact    1620

ggtgacgtgt ggagctcatg ggaacaactg gcctcctccg tgccggaaat cttacagttc    1680

aaccttctgg gtgtccctct tgtcggagca gacgtgtgtg ggtttcttgg taacacctcc    1740

gaggaactgt gtgtgcgctg gactcaactg ggtgcattct acccattcat gagaaaccac    1800

aactccttgc tgtccctgcc acaagagccc tactcgttca gcgagcctgc acaacaggct    1860

atgcggaagg cactgaccct gagatacgcc ctgcttccac acttatacac tctcttccat    1920

caagcgcatg tggcaggaga aaccgttgca aggcctcttt tccttgaatt ccccaaggat    1980

tcctcgactt ggacggtgga tcatcagctg ctgtggggag aagctctgct gattactcca    2040

gtgttgcaag ccggaaaagc tgaggtgacc ggatactttc cgctgggaac ctggtacgac    2100

ctccagactg tccctgttga agcccttgga tcactgcctc cgcctccggc agctccacgc    2160

gaaccagcta tacattccga gggacagtgg gttacattac cagctcctct ggacacaatc    2220

aacgtccact taagagctgg ctacattatc cctctgcaag gaccaggact gactacgacc    2280

gagagcagac agcagccaat ggcactggct gtggctctga ccaagggagg ggaagctaga    2340

ggagaactct tctgggatga tggggagtcc cttgaagtgc tggaaagagg cgcttacact    2400

caagtcattt tccttgcacg gaacaacacc attgtgaacg aattggtgcg agtgaccagc    2460

gaaggagctg gacttcaact gcagaaggtc actgtgctcg gagtggctac cgctcctcag    2520

caagtgctgt cgaatggagt ccccgtgtca aactttacct actcccctga cactaaggtg    2580

ctcgacattt gcgtgtccct cctgatggga gagcagttcc ttgtgtcctg gtgttga       2637


<210> 54
<211> 54
<212> DNA
<213> Artificial Sequence


<220> 
<223> sp7

<400> 54
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggc           54


<210> 55
<211> 1121
<212> DNA
<213> Artificial Sequence


<220> 
<223> LiMP

<400> 55
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc      60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc     120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc     180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc     240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt     300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag     360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc     420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact     480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag     540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg     600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta     660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac     720

agtgaataga tcctgagaac ttcagggtga gtctatggga ccccaccgcg gtggcggccg     780

tccgccctcg gcaccatcct cacgacaccc aaatatggcg acgggtgagg aatggtgggg     840

agttattttt agagcggtga ggaaggtggg caggcagcag gtgttggcgc tctaaaaata     900

actcccggga gttattttta gagcggagga atggtggaca cccaaatatg gcgacggttc     960

ctcacccgtc gccatatttg ggtgtccgcc ctcggccggg gccgcattcc tgggggccgg    1020

gcggtgctcc cgcccgcctc gataaaaggc tccggggccg gcggcggccc acgagctacc    1080

cggaggagcg ggaggcgcca agctctagaa ctagtggatc t                        1121


