                         SEQUENCE LISTING

<110>  President and Fellows of Harvard College
       The Broad Institute, Inc.
 
<120>  EVOLVED BOTULINUM NEUROTOXINS AND USES THEREOF

<130>  H0824.70330WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/874,443
<151>  2019-07-15

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
1               5                   10                  15      


Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro 
            20                  25                  30          


Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
        35                  40                  45              


Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
    50                  55                  60                  


Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
65                  70                  75                  80  


Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
                85                  90                  95      


Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
            100                 105                 110         


Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
        115                 120                 125             


Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
    130                 135                 140                 


Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
145                 150                 155                 160 


Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
                165                 170                 175     


Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
            180                 185                 190         


Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
        195                 200                 205             


Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu 
    210                 215                 220                 


Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
225                 230                 235                 240 


Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu 
                245                 250                 255     


Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
            260                 265                 270         


Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
        275                 280                 285             


Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
    290                 295                 300                 


Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
305                 310                 315                 320 


Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
                325                 330                 335     


Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
            340                 345                 350         


Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn 
        355                 360                 365             


Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
    370                 375                 380                 


Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
385                 390                 395                 400 


Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
                405                 410                 415     


Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu 
            420                 425                 


<210>  2
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Pro Val Thr Ile Asn Asn Phe Asn Tyr Asn Asp Pro Ile Asp Asn 
1               5                   10                  15      


Asn Asn Ile Ile Met Met Glu Pro Pro Phe Ala Arg Gly Thr Gly Arg 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Tyr Thr Phe Gly Tyr Lys Pro Glu Asp Phe Asn Lys Ser Ser Gly 
    50                  55                  60                  


Ile Phe Asn Arg Asp Val Cys Glu Tyr Tyr Asp Pro Asp Tyr Leu Asn 
65                  70                  75                  80  


Thr Asn Asp Lys Lys Asn Ile Phe Leu Gln Thr Met Ile Lys Leu Phe 
                85                  90                  95      


Asn Arg Ile Lys Ser Lys Pro Leu Gly Glu Lys Leu Leu Glu Met Ile 
            100                 105                 110         


Ile Asn Gly Ile Pro Tyr Leu Gly Asp Arg Arg Val Pro Leu Glu Glu 
        115                 120                 125             


Phe Asn Thr Asn Ile Ala Ser Val Thr Val Asn Lys Leu Ile Ser Asn 
    130                 135                 140                 


Pro Gly Glu Val Glu Arg Lys Lys Gly Ile Phe Ala Asn Leu Ile Ile 
145                 150                 155                 160 


Phe Gly Pro Gly Pro Val Leu Asn Glu Asn Glu Thr Ile Asp Ile Gly 
                165                 170                 175     


Ile Gln Asn His Phe Ala Ser Arg Glu Gly Phe Gly Gly Ile Met Gln 
            180                 185                 190         


Met Lys Phe Cys Pro Glu Tyr Val Ser Val Phe Asn Asn Val Gln Glu 
        195                 200                 205             


Asn Lys Gly Ala Ser Ile Phe Asn Arg Arg Gly Tyr Phe Ser Asp Pro 
    210                 215                 220                 


Ala Leu Ile Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr 
225                 230                 235                 240 


Gly Ile Lys Val Asp Asp Leu Pro Ile Val Pro Asn Glu Lys Lys Phe 
                245                 250                 255     


Phe Met Gln Ser Thr Asp Ala Ile Gln Ala Glu Glu Leu Tyr Thr Phe 
            260                 265                 270         


Gly Gly Gln Asp Pro Ser Ile Ile Thr Pro Ser Thr Asp Lys Ser Ile 
        275                 280                 285             


Tyr Asp Lys Val Leu Gln Asn Phe Arg Gly Ile Val Asp Arg Leu Asn 
    290                 295                 300                 


Lys Val Leu Val Cys Ile Ser Asp Pro Asn Ile Asn Ile Asn Ile Tyr 
305                 310                 315                 320 


Lys Asn Lys Phe Lys Asp Lys Tyr Lys Phe Val Glu Asp Ser Glu Gly 
                325                 330                 335     


Lys Tyr Ser Ile Asp Val Glu Ser Phe Asp Lys Leu Tyr Lys Ser Leu 
            340                 345                 350         


Met Phe Gly Phe Thr Glu Thr Asn Ile Ala Glu Asn Tyr Lys Ile Lys 
        355                 360                 365             


Thr Arg Ala Ser Tyr Phe Ser Asp Ser Leu Pro Pro Val Lys Ile Lys 
    370                 375                 380                 


Asn Leu Leu Asp Asn Glu Ile Tyr Thr Ile Glu Glu Gly Phe Asn Ile 
385                 390                 395                 400 


Ser Asp Lys Asp Met Glu Lys Glu Tyr Arg Gly Gln Asn Lys Ala Ile 
                405                 410                 415     


Asn Lys Gln Ala Tyr Glu Glu Ile Ser Lys Glu His Leu Ala Val Tyr 
            420                 425                 430         


Lys Ile Gln Met 
        435     


<210>  3
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn 
1               5                   10                  15      


Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu 
            20                  25                  30          


Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp 
        35                  40                  45              


Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val 
    50                  55                  60                  


Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp 
65                  70                  75                  80  


Ser Asp Lys Asp Thr Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg 
                85                  90                  95      


Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr 
            100                 105                 110         


Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp 
        115                 120                 125             


Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn 
    130                 135                 140                 


Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly 
145                 150                 155                 160 


Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr 
                165                 170                 175     


Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile 
            180                 185                 190         


Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asp 
        195                 200                 205             


Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile 
    210                 215                 220                 


Leu Ile Leu Met His Glu Leu Asn His Ala Met His Asn Leu Tyr Gly 
225                 230                 235                 240 


Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser Val Thr Ser Asn Ile 
                245                 250                 255     


Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala 
            260                 265                 270         


Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr 
        275                 280                 285             


Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu 
    290                 295                 300                 


Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly 
305                 310                 315                 320 


Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser 
                325                 330                 335     


Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe Val Glu Leu Tyr Asn 
            340                 345                 350         


Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn 
        355                 360                 365             


Val Gln Asn Arg Lys Ile Tyr Leu Ser Asn Val Tyr Thr Pro Val Thr 
    370                 375                 380                 


Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn 
385                 390                 395                 400 


Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser 
                405                 410                 415     


Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu 
            420                 425                 430         


Phe Thr Lys Phe 
        435     


<210>  4
<211>  436
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Thr Trp Pro Val Lys Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp 
1               5                   10                  15      


Asn Asp Ile Leu Tyr Leu Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr 
            20                  25                  30          


Pro Val Lys Ala Phe Met Ile Thr Gln Asn Ile Trp Val Ile Pro Glu 
        35                  40                  45              


Arg Phe Ser Ser Asp Thr Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro 
    50                  55                  60                  


Thr Ser Lys Tyr Gln Ser Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp 
65                  70                  75                  80  


Glu Gln Lys Asp Thr Phe Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg 
                85                  90                  95      


Ile Asn Glu Arg Asp Ile Gly Lys Lys Leu Ile Asn Tyr Leu Val Val 
            100                 105                 110         


Gly Ser Pro Phe Met Gly Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp 
        115                 120                 125             


Phe Thr Arg His Thr Thr Asn Ile Ala Val Glu Lys Phe Glu Asn Gly 
    130                 135                 140                 


Ser Trp Lys Val Thr Asn Ile Ile Thr Pro Ser Val Leu Ile Phe Gly 
145                 150                 155                 160 


Pro Leu Pro Asn Ile Leu Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly 
                165                 170                 175     


Gln Gln Ser Asn Pro Ser Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu 
            180                 185                 190         


Lys Val Ala Pro Glu Phe Leu Leu Thr Phe Ser Asp Val Thr Ser Asn 
        195                 200                 205             


Gln Ser Ser Ala Val Leu Gly Lys Ser Ile Phe Cys Met Asp Pro Val 
    210                 215                 220                 


Ile Ala Leu Met His Glu Leu Thr His Ser Leu His Gln Leu Tyr Gly 
225                 230                 235                 240 


Ile Asn Ile Pro Ser Asp Lys Arg Ile Arg Pro Gln Val Ser Glu Gly 
                245                 250                 255     


Phe Phe Ser Gln Asp Gly Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr 
            260                 265                 270         


Phe Gly Gly Leu Asp Val Glu Ile Ile Pro Gln Ile Glu Arg Ser Gln 
        275                 280                 285             


Leu Arg Glu Lys Ala Leu Gly His Tyr Lys Asp Ile Ala Lys Arg Leu 
    290                 295                 300                 


Asn Asn Ile Asn Lys Thr Ile Pro Ser Ser Trp Ile Ser Asn Ile Asp 
305                 310                 315                 320 


Lys Tyr Lys Lys Ile Phe Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn 
                325                 330                 335     


Thr Gly Asn Phe Val Val Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser 
            340                 345                 350         


Asp Leu Thr Asn Val Met Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn 
        355                 360                 365             


Val Lys Asn Arg Thr His Tyr Phe Ser Arg His Tyr Leu Pro Val Phe 
    370                 375                 380                 


Ala Asn Ile Leu Asp Asp Asn Ile Tyr Thr Ile Arg Asp Gly Phe Asn 
385                 390                 395                 400 


Leu Thr Asn Lys Gly Phe Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu 
                405                 410                 415     


Arg Asn Pro Ala Leu Gln Lys Leu Ser Ser Glu Ser Val Val Asp Leu 
            420                 425                 430         


Phe Thr Lys Val 
        435     


<210>  5
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Pro Lys Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp Arg 
1               5                   10                  15      


Thr Ile Leu Tyr Ile Lys Pro Gly Gly Cys Gln Glu Phe Tyr Lys Ser 
            20                  25                  30          


Phe Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile 
        35                  40                  45              


Gly Thr Thr Pro Gln Asp Phe His Pro Pro Thr Ser Leu Lys Asn Gly 
    50                  55                  60                  


Asp Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Glu Glu Lys 
65                  70                  75                  80  


Asp Arg Phe Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asn 
                85                  90                  95      


Asn Leu Ser Gly Gly Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro 
            100                 105                 110         


Tyr Leu Gly Asn Asp Asn Thr Pro Asp Asn Gln Phe His Ile Gly Asp 
        115                 120                 125             


Ala Ser Ala Val Glu Ile Lys Phe Ser Asn Gly Ser Gln His Ile Leu 
    130                 135                 140                 


Leu Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asp Leu Phe Glu Thr 
145                 150                 155                 160 


Asn Ser Ser Asn Ile Ser Leu Arg Asn Asn Tyr Met Pro Ser Asn His 
                165                 170                 175     


Gly Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe 
            180                 185                 190         


Arg Phe Asn Asp Asn Ser Ile Asn Glu Phe Ile Gln Asp Pro Ala Leu 
        195                 200                 205             


Thr Leu Met His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala 
    210                 215                 220                 


Lys Gly Ile Thr Thr Thr Cys Ile Ile Thr Gln Gln Gln Asn Pro Leu 
225                 230                 235                 240 


Ile Thr Asn Arg Lys Gly Ile Asn Ile Glu Glu Phe Leu Thr Phe Gly 
                245                 250                 255     


Gly Asn Asp Leu Asn Ile Ile Thr Val Ala Gln Tyr Asn Asp Ile Tyr 
            260                 265                 270         


Thr Asn Leu Leu Asn Asp Tyr Arg Lys Ile Ala Ser Lys Leu Ser Lys 
        275                 280                 285             


Val Gln Val Ser Asn Pro Gln Leu Asn Pro Tyr Lys Asp Ile Phe Gln 
    290                 295                 300                 


Glu Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn 
305                 310                 315                 320 


Ile Asn Lys Phe Asp Asp Ile Leu Lys Lys Leu Tyr Ser Phe Thr Glu 
                325                 330                 335     


Phe Asp Leu Ala Thr Lys Phe Gln Val Lys Cys Arg Glu Thr Tyr Ile 
            340                 345                 350         


Gly Gln Tyr Lys Tyr Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile 
        355                 360                 365             


Tyr Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe 
    370                 375                 380                 


Arg Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile Lys Pro Ile Thr 
385                 390                 395                 400 


Gly Arg Gly Leu Val Lys Lys Ile Ile Arg Phe 
                405                 410     


<210>  6
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Val Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Ser Ser Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Asn Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Arg 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Phe Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys Tyr Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Pro Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe 
            420                 425             


<210>  7
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Pro Val Asn Ile Lys Asn Phe Asn Tyr Asn Asp Pro Ile Asn Asn 
1               5                   10                  15      


Asp Asp Ile Ile Met Met Glu Pro Phe Asn Asp Pro Gly Pro Gly Thr 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Arg Ile Ile Asp Arg Ile Trp Ile Val Pro Glu 
        35                  40                  45              


Arg Phe Thr Tyr Gly Phe Gln Pro Asp Gln Phe Asn Ala Ser Thr Gly 
    50                  55                  60                  


Val Phe Ser Lys Asp Val Tyr Glu Tyr Tyr Asp Pro Thr Tyr Leu Lys 
65                  70                  75                  80  


Thr Asp Ala Glu Lys Asp Lys Phe Leu Lys Thr Met Ile Lys Leu Phe 
                85                  90                  95      


Asn Arg Ile Asn Ser Lys Pro Ser Gly Gln Arg Leu Leu Asp Met Ile 
            100                 105                 110         


Val Asp Ala Ile Pro Tyr Leu Gly Asn Ala Ser Thr Pro Pro Asp Lys 
        115                 120                 125             


Phe Ala Ala Asn Val Ala Asn Val Ser Ile Asn Lys Lys Ile Ile Gln 
    130                 135                 140                 


Pro Gly Ala Glu Asp Gln Ile Lys Gly Leu Met Thr Asn Leu Ile Ile 
145                 150                 155                 160 


Phe Gly Pro Gly Pro Val Leu Ser Asp Asn Phe Thr Asp Ser Met Ile 
                165                 170                 175     


Met Asn Gly His Ser Pro Ile Ser Glu Gly Phe Gly Ala Arg Met Met 
            180                 185                 190         


Ile Arg Phe Cys Pro Ser Cys Leu Asn Val Phe Asn Asn Val Gln Glu 
        195                 200                 205             


Asn Lys Asp Thr Ser Ile Phe Ser Arg Arg Ala Tyr Phe Ala Asp Pro 
    210                 215                 220                 


Ala Leu Thr Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr 
225                 230                 235                 240 


Gly Ile Lys Ile Ser Asn Leu Pro Ile Thr Pro Asn Thr Lys Glu Phe 
                245                 250                 255     


Phe Met Gln His Ser Asp Pro Val Gln Ala Glu Glu Leu Tyr Thr Phe 
            260                 265                 270         


Gly Gly His Asp Pro Ser Val Ile Ser Pro Ser Thr Asp Met Asn Ile 
        275                 280                 285             


Tyr Asn Lys Ala Leu Gln Asn Phe Gln Asp Ile Ala Asn Arg Leu Asn 
    290                 295                 300                 


Ile Val Ser Ser Ala Gln Gly Ser Gly Ile Asp Ile Ser Leu Tyr Lys 
305                 310                 315                 320 


Gln Ile Tyr Lys Asn Lys Tyr Asp Phe Val Glu Asp Pro Asn Gly Lys 
                325                 330                 335     


Tyr Ser Val Asp Lys Asp Lys Phe Asp Lys Leu Tyr Lys Ala Leu Met 
            340                 345                 350         


Phe Gly Phe Thr Glu Thr Asn Leu Ala Gly Glu Tyr Gly Ile Lys Thr 
        355                 360                 365             


Arg Tyr Ser Tyr Phe Ser Glu Tyr Leu Pro Pro Ile Lys Thr Glu Lys 
    370                 375                 380                 


Leu Leu Asp Asn Thr Ile Tyr Thr Gln Asn Glu Gly Phe Asn Ile Ala 
385                 390                 395                 400 


Ser Lys Asn Leu Lys Thr Glu Phe Asn Gly Gln Asn Lys Ala Val Asn 
                405                 410                 415     


Lys Glu Ala Tyr Glu Glu Ile Ser Leu Glu His Leu Val Ile Tyr Arg 
            420                 425                 430         


Ile Ala Met Cys Lys Pro Val Met Tyr Lys Asn Ala Pro Pro Thr Pro 
        435                 440                 445             


Gly 
    


<210>  8
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Lys Leu Glu Ile Asn Lys Phe Asn Tyr Asn Asp Pro Ile Asp Gly 
1               5                   10                  15      


Ile Asn Val Ile Thr Met Arg Pro Pro Arg His Ser Asp Lys Ile Asn 
            20                  25                  30          


Lys Gly Lys Gly Pro Phe Lys Ala Phe Gln Val Ile Lys Asn Ile Trp 
        35                  40                  45              


Ile Val Pro Glu Arg Tyr Asn Phe Thr Asn Asn Thr Asn Asp Leu Asn 
    50                  55                  60                  


Ile Pro Ser Glu Pro Ile Met Glu Ala Asp Ala Ile Tyr Asn Pro Asn 
65                  70                  75                  80  


Tyr Leu Asn Thr Pro Ser Glu Lys Asp Glu Phe Leu Gln Gly Val Ile 
                85                  90                  95      


Lys Val Leu Glu Arg Ile Lys Ser Lys Pro Glu Gly Glu Lys Leu Leu 
            100                 105                 110         


Glu Leu Ile Ser Ser Ser Ile Pro Leu Pro Leu Val Ser Asn Gly Ala 
        115                 120                 125             


Leu Thr Leu Ser Asp Asn Glu Thr Ile Ala Tyr Gln Glu Asn Asn Asn 
    130                 135                 140                 


Ile Val Ser Asn Leu Gln Ala Asn Leu Val Ile Tyr Gly Pro Gly Pro 
145                 150                 155                 160 


Asp Ile Ala Asn Asn Ala Thr Tyr Gly Leu Tyr Ser Thr Pro Ile Ser 
                165                 170                 175     


Asn Gly Glu Gly Thr Leu Ser Glu Val Ser Phe Ser Pro Phe Tyr Leu 
            180                 185                 190         


Lys Pro Phe Asp Glu Ser Tyr Gly Asn Tyr Arg Ser Leu Val Asn Ile 
        195                 200                 205             


Val Asn Lys Phe Val Lys Arg Glu Phe Ala Pro Asp Pro Ala Ser Thr 
    210                 215                 220                 


Leu Met His Glu Leu Val His Val Thr His Asn Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Asn Arg Asn Phe Tyr Tyr Asn Phe Asp Thr Gly Lys Ile Glu Thr Ser 
                245                 250                 255     


Arg Gln Gln Asn Ser Leu Ile Phe Glu Glu Leu Leu Thr Phe Gly Gly 
            260                 265                 270         


Ile Asp Ser Lys Ala Ile Ser Ser Leu Ile Ile Lys Lys Ile Ile Glu 
        275                 280                 285             


Thr Ala Lys Asn Asn Tyr Thr Thr Leu Ile Ser Glu Arg Leu Asn Thr 
    290                 295                 300                 


Val Thr Val Glu Asn Asp Leu Leu Lys Tyr Ile Lys Asn Lys Ile Pro 
305                 310                 315                 320 


Val Gln Gly Arg Leu Gly Asn Phe Lys Leu Asp Thr Ala Glu Phe Glu 
                325                 330                 335     


Lys Lys Leu Asn Thr Ile Leu Phe Val Leu Asn Glu Ser Asn Leu Ala 
            340                 345                 350         


Gln Arg Phe Ser Ile Leu Val Arg Lys His Tyr Leu Lys Glu Arg Pro 
        355                 360                 365             


Ile Asp Pro Ile Tyr Val Asn Ile Leu Asp Asp Asn Ser Tyr Ser Thr 
    370                 375                 380                 


Leu Glu Gly Phe Asn Ile Ser Ser Gln Gly Ser Asn Asp Phe Gln Gly 
385                 390                 395                 400 


Gln Leu Leu Glu Ser Ser Tyr Phe Glu Lys Ile Glu Ser Asn Ala Leu 
                405                 410                 415     


Arg Ala Phe Ile Lys Ile Cys Pro Arg Asn Gly Leu Leu Tyr Asn Ala 
            420                 425                 430         


Ile Tyr Arg Asn Ser Lys Asn 
        435                 


<210>  9
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Val Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Ser Ser Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Asn Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Arg 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Phe Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys Tyr Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Pro Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe 
            420                 425             


<210>  10
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Cys Lys Ser Val Ile Pro Arg Lys Gly Thr Lys Ala Pro Pro Arg Leu 
1               5                   10                  15      


Cys Ile Arg Val Asn Asn Arg Glu Leu Phe Phe Val Ala Ser Glu Ser 
            20                  25                  30          


Ser Tyr Asn Glu Asn Asp Ile Asn Thr Pro Lys Glu Ile Asp Asp Thr 
        35                  40                  45              


Thr Asn Leu Asn Asn Asn Tyr Arg Asn Asn Leu Asp Glu Val Ile Leu 
    50                  55                  60                  


Asp Tyr Asn Ser Glu Thr Ile Pro Gln Ile Ser Asn Gln Thr Leu Asn 
65                  70                  75                  80  


Thr Leu Val Gln Asp Asp Ser Tyr Val Pro Arg Tyr Asp Ser Asn Gly 
                85                  90                  95      


Thr Ser Glu Ile Glu Glu His Asn Val Val Asp Leu Asn Val Phe Phe 
            100                 105                 110         


Tyr Leu His Ala Gln Lys Val Pro Glu Gly Glu Thr Asn Ile Ser Leu 
        115                 120                 125             


Thr Ser Ser Ile Asp Thr Ala Leu Ser Glu Glu Ser Gln Val Tyr Thr 
    130                 135                 140                 


Phe Phe Ser Ser Glu Phe Ile Asn Thr Ile Asn Lys Pro Val His Ala 
145                 150                 155                 160 


Ala Leu Phe Ile Ser Trp Ile Asn Gln Val Ile Arg Asp Phe Thr Thr 
                165                 170                 175     


Glu Ala Thr Gln Lys Ser Thr Phe Asp Lys Ile Ala Asp Ile Ser Leu 
            180                 185                 190         


Val Val Pro Tyr Val Gly Leu Ala Leu Asn Ile Gly Asn Glu Val Gln 
        195                 200                 205             


Lys Glu Asn Phe Lys Glu Ala Phe Glu Leu Leu Gly Ala Gly Ile Leu 
    210                 215                 220                 


Leu Glu Phe Val Pro Glu Leu Leu Ile Pro Thr Ile Leu Val Phe Thr 
225                 230                 235                 240 


Ile Lys Ser Phe Ile Gly Ser Ser Glu Asn Lys Asn Lys Ile Ile Lys 
                245                 250                 255     


Ala Ile Asn Asn Ser Leu Met Glu Arg Glu Thr Lys Trp Lys Glu Ile 
            260                 265                 270         


Tyr Ser Trp Ile Val Ser Asn Trp Leu Thr Arg Ile Asn Thr Gln Phe 
        275                 280                 285             


Asn Lys Arg Lys Glu Gln Met Tyr Gln Ala Leu Gln Asn Gln Val Asp 
    290                 295                 300                 


Ala Ile Lys Thr Val Ile Glu Tyr Lys Tyr Asn Asn Tyr Thr Ser Asp 
305                 310                 315                 320 


Glu Arg Asn Arg Leu Glu Ser Glu Tyr Asn Ile Asn Asn Ile Arg Glu 
                325                 330                 335     


Glu Leu Asn Lys Lys Val Ser Leu Ala Met Glu Asn Ile Glu Arg Phe 
            340                 345                 350         


Ile Thr Glu Ser Ser Ile Phe Tyr Leu Met Lys Leu Ile Asn Glu Ala 
        355                 360                 365             


Lys Val Ser Lys Leu Arg Glu Tyr Asp Glu Gly Val Lys Glu Tyr Leu 
    370                 375                 380                 


Leu Asp Tyr Ile Ser Glu His Arg Ser Ile Leu Gly Asn Ser Val Gln 
385                 390                 395                 400 


Glu Leu Asn Asp Leu Val Thr Ser Thr Leu Asn Asn Ser Ile Pro Phe 
                405                 410                 415     


Glu Leu Ser Ser Tyr Thr Asn Asp Lys Ile Leu Ile Leu Tyr Phe 
            420                 425                 430     


<210>  11
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Asn Lys Leu Tyr Lys Lys Ile Lys Asp Asn Ser Ile Leu Asp Met Arg 
1               5                   10                  15      


Tyr Glu Asn Asn Lys Phe Ile Asp Ile Ser Gly Tyr Gly Ser Asn Ile 
            20                  25                  30          


Ser Ile Asn Gly Asp Val Tyr Ile Tyr Ser Thr Asn Arg Asn Gln Phe 
        35                  40                  45              


Gly Ile Tyr Ser Ser Lys Pro Ser Glu Val Asn Ile Ala Gln Asn Asn 
    50                  55                  60                  


Asp Ile Ile Tyr Asn Gly Arg Tyr Gln Asn Phe Ser Ile Ser Phe Trp 
65                  70                  75                  80  


Val Arg Ile Pro Lys Tyr Phe Asn Lys Val Asn Leu Asn Asn Glu Tyr 
                85                  90                  95      


Thr Ile Ile Asp Cys Ile Arg Asn Asn Asn Ser Gly Trp Lys Ile Ser 
            100                 105                 110         


Leu Asn Tyr Asn Lys Ile Ile Trp Thr Leu Gln Asp Thr Ala Gly Asn 
        115                 120                 125             


Asn Gln Lys Leu Val Phe Asn Tyr Thr Gln Met Ile Ser Ile Ser Asp 
    130                 135                 140                 


Tyr Ile Asn Lys Trp Ile Phe Val Thr Ile Thr Asn Asn Arg Leu Gly 
145                 150                 155                 160 


Asn Ser Arg Ile Tyr Ile Asn Gly Asn Leu Ile Asp Glu Lys Ser Ile 
                165                 170                 175     


Ser Asn Leu Gly Asp Ile His Val Ser Asp Asn Ile Leu Phe Lys Ile 
            180                 185                 190         


Val Gly Cys Asn Asp Thr Arg Tyr Val Gly Ile Arg Tyr Phe Lys Val 
        195                 200                 205             


Phe Asp Thr Glu Leu Gly Lys Thr Glu Ile Glu Thr Leu Tyr Ser Asp 
    210                 215                 220                 


Glu Pro Asp Pro Ser Ile Leu Lys Asp Phe Trp Gly Asn Tyr Leu Leu 
225                 230                 235                 240 


Tyr Asn Lys Arg Tyr Tyr Leu Leu Asn Leu Leu Arg Thr Asp Lys Ser 
                245                 250                 255     


Ile Thr Gln Asn Ser Asn Phe Leu Asn Ile Asn Gln Gln Arg Gly Val 
            260                 265                 270         


Tyr Gln Lys Pro Asn Ile Phe Ser Asn Thr Arg Leu Tyr Thr Gly Val 
        275                 280                 285             


Glu Val Ile Ile Arg Lys Asn Gly Ser Thr Asp Ile Ser Asn Thr Asp 
    290                 295                 300                 


Asn Phe Val Arg Lys Asn Asp Leu Ala Tyr Ile Asn Val Val Asp Arg 
305                 310                 315                 320 


Asp Val Glu Tyr Arg Leu Tyr Ala Asp Ile Ser Ile Ala Lys Pro Glu 
                325                 330                 335     


Lys Ile Ile Lys Leu Ile Arg Thr Ser Asn Ser Asn Asn Ser Leu Gly 
            340                 345                 350         


Gln Ile Ile Val Met Asp Ser Ile Gly Asn Asn Cys Thr Met Asn Phe 
        355                 360                 365             


Gln Asn Asn Asn Gly Gly Asn Ile Gly Leu Leu Gly Phe His Ser Asn 
    370                 375                 380                 


Asn Leu Val Ala Ser Ser Trp Tyr Tyr Asn Asn Ile Arg Lys Asn Thr 
385                 390                 395                 400 


Ser Ser Asn Gly Cys Phe Trp Ser Phe Ile Ser Lys Glu His Gly Trp 
                405                 410                 415     


Gln Glu Asn 
            


<210>  12
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Val Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Ser Ser Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Asn Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Arg 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Phe Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys Tyr Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Pro Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe 
            420                 425             


<210>  13
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met His Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Asn 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Val Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ser Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Asn Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Phe Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Pro Lys Ile Ile Gly Ser Ile 
                405                 410                 415     


Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe 
            420                 425             


<210>  14
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met His Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Asn 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Val Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ser Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Asn Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Cys 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Phe Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Pro Lys Ile Ile Gly Ser Ile 
                405                 410                 415     


Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe 
            420                 425             


<210>  15
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Val Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ser Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser His Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Gly Ser Ile 
                405                 410                 415     


Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe 
            420                 425             


<210>  16
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Val Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ser Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Lys Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Gly Ser Ile 
                405                 410                 415     


Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe 
            420                 425             


<210>  17
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Val Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ser Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Lys Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  18
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Ser Tyr Ile Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Lys Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  19
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Asp Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser His Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Lys Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Cys Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  20
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Asp Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Lys Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Lys Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Cys Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  21
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Asp Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Ser Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Lys Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Cys Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  22
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Ser Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser His Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Lys Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Cys Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  23
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Ser Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Lys Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Lys Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Cys Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  24
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Ser Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Met Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Ser Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Lys Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Cys Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  25
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Asp Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Met Gly Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Lys Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Gly Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Ile Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Ser Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Tyr Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  26
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Asp Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Met Gly Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Lys Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Gly Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Ile Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Phe 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Ser Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Tyr Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  27
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala His Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Ser Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Gly Thr Arg Thr Thr Ser Val Asn Ile Lys Thr Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Thr Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Thr Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Met Thr Phe Ser Pro Glu Tyr Gly Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Ile Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  28
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala His Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Ser Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Gly Thr Arg Thr Thr Ser Val Asn Ile Lys Thr Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Thr Asp Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Thr Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Met Thr Phe Ser Pro Glu Tyr Gly Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Ile Ser Phe Ile Ala Asp Pro Ala Ile Ser 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Phe 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Gly Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  29
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala His Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Gly Thr Arg Thr Thr Ser Val Asn Ile Lys Thr Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Met Thr Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Asn Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Gly Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ile 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Gly Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys His Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  30
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Leu Ser Ala His Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Asn Ile Val Leu Asn Leu Leu Val Leu Gly Pro Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Ile Tyr Pro Val Arg Lys Leu Met Met Ser 
                165                 170                 175     


Asp Gly Val Tyr Asp Pro Ser His Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Gly Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ile 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Arg Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Gly Phe Thr 
            340                 345                 350         


Glu Ile Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys Asn Gly Phe Leu Lys Val Pro Asn Leu Met Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Ile Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  31
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Met Pro Val Val Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp 
1               5                   10                  15      


Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Asn Lys 
            20                  25                  30          


Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu 
        35                  40                  45              


Arg Asn Thr Ile Gly Thr Asp Pro Ser Asp Phe Asp Pro Pro Ala Ser 
    50                  55                  60                  


Leu Glu Asn Gly Ser Ser Ala His Tyr Asp Pro Asn Tyr Leu Thr Thr 
65                  70                  75                  80  


Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Asn 
                85                  90                  95      


Arg Ile Asn Ser Asn Pro Ala Gly Glu Ala Leu Leu Gln Glu Ile Ser 
            100                 105                 110         


Tyr Ala Lys Pro Tyr Leu Gly Asn Glu His Thr Pro Ile Asn Glu Phe 
        115                 120                 125             


His Pro Phe Thr Arg Thr Thr Ser Val Asn Ile Lys Ser Ser Thr Asn 
    130                 135                 140                 


Val Lys Ser Ser Ile Ile Leu Asn Leu Leu Val Leu Gly Ala Gly Pro 
145                 150                 155                 160 


Asp Ile Phe Glu Asn Tyr Leu Tyr Pro Val Arg Lys Leu Met Met Ser 
                165                 170                 175     


Gly Gly Val Tyr Asp Pro Ser Asn Asp Gly Phe Gly Ser Ile Asn Ile 
            180                 185                 190         


Val Thr Phe Ser Pro Glu Tyr Gly Tyr Thr Phe Asn Asp Ile Ser Gly 
        195                 200                 205             


Gly Tyr Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ile 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Leu 
225                 230                 235                 240 


Gly Val Thr Tyr Lys Glu Thr Ile Lys Val Lys Gln Ala Pro Leu Met 
                245                 250                 255     


Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly 
            260                 265                 270         


Gln Asp Leu Asn Ile Ile Thr Ser Val Met Lys Glu Lys Ile Tyr Asn 
        275                 280                 285             


Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser His Val 
    290                 295                 300                 


Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe 
305                 310                 315                 320 


Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val 
                325                 330                 335     


Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Gly Phe Thr 
            340                 345                 350         


Glu Val Asp Leu Ala Asn Lys Leu Lys Val Lys Cys Arg Asn Thr Tyr 
        355                 360                 365             


Phe Ile Lys Pro Gly Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp 
    370                 375                 380                 


Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly His Leu Ala Val Asn 
385                 390                 395                 400 


Asn Arg Gly Gln Asn Ile Lys Leu Asn Leu Lys Asn Ile Asp Ser Ile 
                405                 410                 415     


Pro Asp Lys Ala Trp Leu Arg Lys Ser 
            420                 425 


<210>  32
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Met Ser Ala Pro Ala Gln Pro Pro Ala Glu Gly Thr Glu Gly Thr Ala 
1               5                   10                  15      


Pro Gly Gly Gly Pro Pro Gly Pro Pro Pro Asn Met Thr Ser Asn Arg 
            20                  25                  30          


Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val Val Asp Ile Ile 
        35                  40                  45              


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
    50                  55                  60                  


Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu 
65                  70                  75                  80  


Ser Ser Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys 
                85                  90                  95      


Met Met Ile Met Leu Gly Ala Ile Cys Ala Ile Ile Val Val Val Ile 
            100                 105                 110         


Val Arg Arg Gly 
        115     


<210>  33
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu Lys Arg 
    50                  55                  60  


<210>  34
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Met Ala Ile Leu Phe Ala Val Val Ala Arg Gly Thr Thr Ile Leu Ala 
1               5                   10                  15      


Lys His Ala Trp Cys Gly Gly Asn Phe Leu Glu Asp Phe Glu Arg Ser 
            20                  25                  30          


Arg Ala Phe Asn Phe Leu Asn Glu Ile Lys Lys Arg Phe Gln Thr Thr 
        35                  40                  45              


Tyr Gly Ser Arg Ala Gln Thr Ala Leu Pro Tyr Ala Met Asn Ser Glu 
    50                  55                  60                  


Phe Ser Ser Val Leu Ala Ala Gln Leu Lys His His Ser Glu Asn Lys 
65                  70                  75                  80  


Gly Leu Asp Lys Val Met Glu Thr Gln Ala Gln Val Asp Glu Leu Lys 
                85                  90                  95      


Gly Ile Met Val Arg Asn Ile Asp Leu Val Ala Gln Arg Gly Glu Arg 
            100                 105                 110         


Leu Glu Leu Leu Ile Asp Lys Thr Glu Asn Leu Val Asp Ser Ser Val 
        115                 120                 125             


Thr Phe Lys Thr Thr Ser Arg Asn Leu Ala Arg Ala Met Cys Met Lys 
    130                 135                 140                 


Asn Leu Lys Leu Thr Ile Ile Ile Ile Ile Val Ser Ile Val Phe Ile 
145                 150                 155                 160 


Tyr Ile Ile Val Ser Pro Leu Cys Gly Gly Phe Thr Trp Pro Ser Cys 
                165                 170                 175     


Val Lys Lys 
            


<210>  35
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Lys Gly Leu Asp Lys Val Met Glu Thr Gln Ala Gln Val Asp Glu Leu 
1               5                   10                  15      


Lys Gly Ile Met Val Arg Asn Ile Asp Leu Val Ala Gln Arg Gly Glu 
            20                  25                  30          


Arg Leu Glu Leu Leu Ile Asp Lys Thr Glu Asn Leu Val Asp Ser Ser 
        35                  40                  45              


Val Thr Phe Lys Thr Thr Ser Arg Asn Leu Ala Arg Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Gly Gly Ser 
65                  


<210>  36
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Met Lys Leu Glu Ile Asn Lys Phe Asn Tyr Asn Asp Pro Ile Asp Gly 
1               5                   10                  15      


Ile Asn Val Ile Thr Met Arg Pro Pro Arg His Ser Asp Lys Ile Asn 
            20                  25                  30          


Lys Gly Lys Gly Pro Phe Lys Ala Phe Gln Val Ile Lys Asn Ile Trp 
        35                  40                  45              


Ile Val Pro Glu Arg Tyr Asn Phe Thr Asn Asn Thr Asn Asp Leu Asn 
    50                  55                  60                  


Ile Pro Ser Glu Pro Ile Met Glu Ala Asp Ala Ile Tyr Asn Pro Asn 
65                  70                  75                  80  


Tyr Leu Asn Thr Pro Ser Glu Lys Asp Glu Phe Leu Gln Gly Val Ile 
                85                  90                  95      


Lys Gly Leu Glu Arg Ile Lys Ser Lys Pro Glu Gly Glu Lys Leu Leu 
            100                 105                 110         


Lys Leu Ile Ser Ser Ser Ile Pro Leu Pro Leu Val Ser Asn Gly Ala 
        115                 120                 125             


Leu Thr Leu Ser Asp Asn Glu Thr Ile Ala Tyr Gln Glu Asn Asn Asn 
    130                 135                 140                 


Ile Val Ser Asn Leu Gln Ala Asn Leu Val Ile Tyr Gly Pro Gly Pro 
145                 150                 155                 160 


Asp Ile Ala Asn Asn Glu Thr Tyr Gly Leu Tyr Ser Thr Pro Ile Ser 
                165                 170                 175     


Asn Gly Glu Gly Thr Leu Ser Glu Val Ser Phe Ser Pro Phe Tyr Leu 
            180                 185                 190         


Lys Pro Phe Asp Glu Ser Tyr Gly Asn Tyr Arg Ser Leu Val Asn Ile 
        195                 200                 205             


Val Asn Lys Phe Val Lys Arg Glu Phe Ala Pro Asp Pro Ala Ser Thr 
    210                 215                 220                 


Leu Met His Glu Leu Val His Val Thr His Asn Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Asn Arg Asn Phe Tyr Tyr Asn Phe Asp Thr Gly Lys Ile Glu Thr Ser 
                245                 250                 255     


Arg Gln Gln Asn Ser Leu Ile Phe Glu Glu Leu Leu Thr Phe Gly Gly 
            260                 265                 270         


Ile Asp Ser Lys Ala Ile Ser Leu Leu Ile Ile Lys Lys Ile Ile Glu 
        275                 280                 285             


Thr Ala Lys Asn Asn Tyr Thr Thr Leu Ile Ser Glu Arg Leu Asn Thr 
    290                 295                 300                 


Val Thr Val Glu Asn Asp Leu Leu Lys Tyr Ile Lys Asn Lys Ile Pro 
305                 310                 315                 320 


Val Gln Gly Arg Leu Gly Asn Phe Lys Leu Asp Thr Ala Glu Phe Glu 
                325                 330                 335     


Lys Lys Leu Asn Thr Ile Leu Phe Val Leu Asn Glu Ser Asn Leu Ala 
            340                 345                 350         


Gln Arg Phe Ser Ile Leu Val Arg Lys His Tyr Leu Lys Glu Arg Pro 
        355                 360                 365             


Ile Asp Pro Ile Tyr Val Asn Ile Leu Asp Asp Asn Ser Tyr Ser Thr 
    370                 375                 380                 


Leu Glu Gly Phe Asn Ile Ser Ser Gln Gly Ser Asn Asp Phe Gln Gly 
385                 390                 395                 400 


Gln Leu Leu Glu Ser Ser Tyr Phe Glu Lys Ile Glu Ser Asn Ala Leu 
                405                 410                 415     


Arg Ala Phe Ile Lys Ile Cys Pro Arg Asn Gly Leu Leu Tyr Asn Ala 
            420                 425                 430         


Ile Tyr Arg Asn Ser Lys Asn 
        435                 


<210>  37
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Met Lys Leu Glu Ile Asn Lys Phe Asn Tyr Asn Asp Pro Ile Asp Gly 
1               5                   10                  15      


Ile Asn Val Ile Thr Met Arg Pro Pro Arg His Ser Asp Lys Ile Asn 
            20                  25                  30          


Lys Gly Lys Gly Pro Phe Lys Ala Phe Gln Val Ile Lys Asn Ile Trp 
        35                  40                  45              


Ile Val Pro Glu Arg Tyr Asn Phe Thr Asn Asn Thr Asn Asp Leu Asn 
    50                  55                  60                  


Ile Pro Ser Glu Pro Ile Met Glu Ala Asp Ala Ile Tyr Asn Pro Asn 
65                  70                  75                  80  


Tyr Leu Asn Thr Pro Ser Glu Lys Asp Glu Phe Leu Gln Gly Val Ile 
                85                  90                  95      


Lys Val Leu Glu Arg Ile Lys Ser Lys Pro Glu Gly Glu Lys Leu Leu 
            100                 105                 110         


Glu Leu Ile Ser Ser Ser Ile Pro Leu Pro Leu Val Ser Asn Gly Ala 
        115                 120                 125             


Leu Thr Leu Ser Asp Asn Glu Thr Ile Ala Tyr Gln Glu Asn Asn Asn 
    130                 135                 140                 


Ile Val Ser Asn Leu Gln Ala Asn Leu Val Ile Tyr Gly Pro Gly Pro 
145                 150                 155                 160 


Asp Ile Ala Asn Asn Glu Thr Tyr Gly Leu Tyr Ser Thr Pro Ile Ser 
                165                 170                 175     


Asn Gly Glu Gly Thr Leu Ser Glu Val Ser Phe Ser Pro Phe Tyr Leu 
            180                 185                 190         


Lys Pro Phe Asp Glu Ser Tyr Gly Asn Tyr Arg Ser Leu Val Asn Ile 
        195                 200                 205             


Val Asn Lys Phe Val Lys Arg Glu Phe Ala Pro Asp Pro Ala Ser Thr 
    210                 215                 220                 


Leu Met His Glu Leu Val His Val Thr His Asn Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Asn Arg Asn Phe Tyr Tyr Asn Phe Asp Thr Gly Lys Ile Glu Thr Ser 
                245                 250                 255     


Arg Gln Gln Asn Ser Leu Ile Phe Glu Glu Leu Leu Thr Phe Gly Gly 
            260                 265                 270         


Ile Asp Ser Lys Ala Ile Ser Ser Leu Ile Ile Lys Lys Ile Ile Glu 
        275                 280                 285             


Thr Ala Lys Asn Asn Tyr Thr Thr Leu Ile Ser Glu Arg Leu Asn Thr 
    290                 295                 300                 


Val Thr Val Glu Asn Asp Leu Leu Lys Tyr Ile Lys Asn Lys Ile Pro 
305                 310                 315                 320 


Val Gln Gly Arg Leu Gly Asn Phe Lys Leu Asp Thr Ala Glu Phe Glu 
                325                 330                 335     


Lys Lys Leu Asn Thr Ile Leu Phe Val Leu Asn Glu Ser Asn Leu Ala 
            340                 345                 350         


Gln Arg Phe Ser Ile Leu Val Arg Lys His Tyr Leu Lys Glu Arg Pro 
        355                 360                 365             


Ile Asp Pro Ile Tyr Val Asn Ile Leu Asp Asp Asn Ser Tyr Ser Thr 
    370                 375                 380                 


Leu Glu Gly Phe Asn Ile Ser Ser Gln Gly Ser Asn Asp Phe Gln Gly 
385                 390                 395                 400 


Gln Leu Leu Glu Ser Ser Tyr Phe Glu Lys Ile Glu Ser Asn Ala Leu 
                405                 410                 415     


Arg Ala Phe Ile Lys Ile Cys Pro Arg Asn Gly Leu Leu Tyr Asn Ala 
            420                 425                 430         


Ile Tyr Arg Asn Ser Lys Asn 
        435                 


<210>  38
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Met Lys Leu Glu Ile Asn Lys Phe Asn Tyr Asn Asp Pro Ile Asp Gly 
1               5                   10                  15      


Ile Asn Val Ile Thr Met Arg Pro Pro Arg His Ser Asp Lys Ile Asn 
            20                  25                  30          


Lys Gly Lys Gly Pro Phe Lys Ala Phe Gln Val Ile Lys Asn Ile Trp 
        35                  40                  45              


Ile Val Pro Glu Arg Tyr Asn Phe Thr Asn Asn Thr Asn Asp Leu Asn 
    50                  55                  60                  


Ile Pro Ser Glu Pro Ile Met Glu Ala Asp Ala Ile Tyr Asn Pro Asn 
65                  70                  75                  80  


Tyr Leu Asn Thr Pro Ser Glu Lys Asp Glu Phe Leu Gln Gly Val Ile 
                85                  90                  95      


Lys Val Leu Glu Arg Ile Lys Ser Lys Pro Glu Gly Glu Lys Leu Leu 
            100                 105                 110         


Glu Leu Ile Ser Ser Ser Ile Pro Leu Pro Leu Val Ser Asn Gly Ala 
        115                 120                 125             


Leu Thr Leu Ser Asp Asn Glu Thr Ile Ala Tyr Gln Glu Asn Asn Asn 
    130                 135                 140                 


Ile Val Ser Asn Leu Gln Ala Asn Leu Val Ile Tyr Gly Pro Gly Pro 
145                 150                 155                 160 


Asp Ile Ala Asn Asn Glu Thr Tyr Gly Leu Tyr Ser Thr Pro Ile Ser 
                165                 170                 175     


Asn Gly Glu Gly Thr Leu Ser Glu Val Ser Phe Ser Pro Phe Tyr Leu 
            180                 185                 190         


Lys Pro Phe Asp Glu Ser Tyr Gly Asn Tyr Arg Ser Leu Val Asn Ile 
        195                 200                 205             


Val Asn Lys Phe Val Lys Arg Glu Phe Ala Pro Asp Pro Ala Ser Thr 
    210                 215                 220                 


Leu Met His Glu Leu Val His Val Thr His Asn Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Asn Arg Asn Phe Tyr Tyr Asn Phe Asp Thr Gly Lys Ile Glu Thr Ser 
                245                 250                 255     


Arg Gln Gln Asn Ser Leu Ile Phe Glu Glu Leu Leu Thr Phe Gly Gly 
            260                 265                 270         


Ile Asp Ser Lys Ala Ile Ser Ser Leu Ile Ile Lys Lys Ile Ile Glu 
        275                 280                 285             


Thr Ala Lys Asn Asn Tyr Thr Thr Leu Ile Ser Glu Arg Leu Asn Thr 
    290                 295                 300                 


Val Thr Val Glu Asn Asp Leu Leu Lys Tyr Ile Lys Asn Lys Ile Pro 
305                 310                 315                 320 


Val Gln Gly Arg Leu Gly Asn Phe Lys Leu Asp Thr Ala Glu Phe Glu 
                325                 330                 335     


Lys Lys Leu Asn Thr Ile Leu Phe Val Leu Asn Glu Ser Asn Leu Ala 
            340                 345                 350         


Gln Arg Phe Ser Ile Leu Val Arg Lys His Tyr Leu Lys Glu Arg Pro 
        355                 360                 365             


Ile Asp Pro Ile Tyr Val Asn Ile Leu Asp Asp Asn Ser Tyr Ser Thr 
    370                 375                 380                 


Leu Glu Gly Phe Asn Ile Ser Ser Gln Gly Ser Asn Asp Phe Gln Gly 
385                 390                 395                 400 


Gln Leu Leu Glu Leu Ser Tyr Phe Glu Lys Ile Glu Ser Asn Ala Leu 
                405                 410                 415     


Arg Ala Phe Ile Lys Ile Cys Pro Arg Asn Gly Leu Leu Tyr Asn Ala 
            420                 425                 430         


Ile Tyr Leu Asn Ser Lys Asn 
        435                 


<210>  39
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Met Lys Leu Glu Ile Asn Lys Phe Asn Tyr Asn Asp Pro Ile Asp Gly 
1               5                   10                  15      


Ile Asn Val Ile Thr Met Arg Pro Pro Arg His Ser Asp Lys Ile Asn 
            20                  25                  30          


Lys Gly Lys Gly Pro Phe Lys Ala Phe Gln Val Ile Lys Asn Ile Trp 
        35                  40                  45              


Ile Val Pro Glu Arg Tyr Asn Phe Thr Asn Asn Thr Asn Asp Leu Asn 
    50                  55                  60                  


Ile Pro Ser Ala Pro Ile Met Glu Ala Asp Ala Ile Tyr Asn Pro Asn 
65                  70                  75                  80  


Tyr Leu Asn Thr Pro Ser Glu Lys Asp Glu Phe Leu Gln Gly Val Ile 
                85                  90                  95      


Lys Val Leu Glu Arg Ile Lys Ser Lys Pro Glu Gly Glu Lys Leu Leu 
            100                 105                 110         


Glu Leu Ile Ser Ser Ser Ile Pro Leu Pro Leu Val Ser Asn Gly Ala 
        115                 120                 125             


Leu Thr Leu Ser Asp Asn Glu Thr Ile Ala Tyr Gln Glu Asn Asn Asn 
    130                 135                 140                 


Ile Val Ser Asn Leu Leu Ala Asn Leu Val Ile Tyr Gly Pro Gly Pro 
145                 150                 155                 160 


Asp Ile Ala Asn Asn Glu Thr Tyr Gly Leu Tyr Ser Thr Pro Ile Ser 
                165                 170                 175     


Asn Gly Glu Gly Thr Leu Ser Glu Val Ser Phe Ser Pro Phe Tyr Leu 
            180                 185                 190         


Lys Pro Phe Asp Glu Ser Tyr Gly Asn Tyr Arg Ser Leu Val Asn Ile 
        195                 200                 205             


Val Asn Lys Phe Val Lys Arg Glu Phe Ala Pro Asp Pro Ala Ser Thr 
    210                 215                 220                 


Leu Met His Glu Leu Val His Val Thr His Asn Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Asn Arg Asn Phe Tyr Tyr Asn Phe Asp Thr Gly Lys Ile Glu Thr Ser 
                245                 250                 255     


Arg Gln Gln Asn Ser Leu Ile Phe Glu Glu Leu Leu Thr Phe Gly Gly 
            260                 265                 270         


Ile Asp Ser Lys Ala Ile Ser Ser Leu Ile Ile Lys Lys Ile Ile Glu 
        275                 280                 285             


Thr Ala Lys Asn Asn Tyr Thr Thr Leu Ile Ser Glu Arg Leu Asn Thr 
    290                 295                 300                 


Val Thr Val Glu Asn Asp Leu Leu Lys Tyr Ile Lys Asn Lys Ile Pro 
305                 310                 315                 320 


Val Gln Gly Arg Leu Gly Asn Phe Lys Leu Asp Thr Ala Glu Phe Glu 
                325                 330                 335     


Lys Lys Leu Asn Thr Ile Leu Phe Val Leu Asn Glu Ser Asn Leu Ala 
            340                 345                 350         


Gln Arg Phe Ser Ile Leu Val Arg Lys His Tyr Leu Lys Glu Arg Pro 
        355                 360                 365             


Ile Asp Pro Ile Tyr Val Asn Ile Leu Asp Asp Asn Ser Tyr Ser Thr 
    370                 375                 380                 


Leu Glu Gly Phe Asn Ile Ser Ser Gln Gly Ser Asn Asp Phe Gln Gly 
385                 390                 395                 400 


Gln Leu Leu Glu Ser Ser Tyr Phe Glu Lys Ile Glu Ser Asn Ala Leu 
                405                 410                 415     


Arg Ala Phe Ile Lys Ile Cys Pro Arg Asn Gly Leu Leu Tyr Asn Ala 
            420                 425                 430         


Ile Tyr Arg Asn Ser Lys Asn 
        435                 


<210>  40
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Lys Leu Glu Ile Asn Lys Phe Asn Tyr Asn Asp Pro Ile Asp Gly 
1               5                   10                  15      


Ile Asn Val Ile Thr Met Arg Pro Pro Arg His Ser Asp Lys Ile Asn 
            20                  25                  30          


Lys Gly Lys Gly Pro Phe Lys Ala Phe Gln Val Ile Lys Asn Ile Trp 
        35                  40                  45              


Ile Val Pro Glu Arg Tyr Asn Phe Thr Asn Asn Thr Asn Asp Leu Asn 
    50                  55                  60                  


Ile Pro Ser Glu Pro Ile Met Glu Ala Asp Ala Ile Tyr Asn Pro Asn 
65                  70                  75                  80  


Tyr Leu Asn Thr Pro Ser Glu Lys Asp Glu Phe Leu Gln Gly Val Ile 
                85                  90                  95      


Lys Val Leu Glu Arg Ile Lys Ser Lys Pro Glu Gly Glu Lys Leu Leu 
            100                 105                 110         


Glu Leu Ile Ser Ser Ser Ile Pro Leu Pro Leu Val Ser Asn Gly Ala 
        115                 120                 125             


Leu Thr Leu Ser Asp Asn Glu Thr Ile Ala Tyr Gln Glu Asn Asn Asn 
    130                 135                 140                 


Ile Val Ser Asn Leu Gln Ala Asn Leu Val Ile Tyr Gly Pro Gly Pro 
145                 150                 155                 160 


Asp Ile Ala Asn Asn Glu Thr Tyr Gly Leu Tyr Ser Thr Pro Ile Ser 
                165                 170                 175     


Asn Gly Glu Gly Thr Leu Ser Glu Val Ser Phe Ser Pro Phe Tyr Leu 
            180                 185                 190         


Lys Pro Phe Asp Glu Ser Tyr Gly Asn Tyr Arg Ser Leu Val Asn Ile 
        195                 200                 205             


Val Asn Lys Phe Val Lys Arg Glu Phe Ala Pro Asp Pro Ala Ser Thr 
    210                 215                 220                 


Leu Met His Glu Leu Val His Val Thr His Asn Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Asn Arg Asn Phe Tyr Tyr Asn Phe Asp Thr Gly Lys Ile Glu Thr Ser 
                245                 250                 255     


Arg Gln Gln Asn Ser Leu Ile Phe Glu Glu Leu Leu Thr Phe Gly Gly 
            260                 265                 270         


Ile Asp Ser Lys Ala Ile Ser Ser Leu Ile Ile Lys Lys Ile Ile Glu 
        275                 280                 285             


Thr Ala Lys Asn Asn Tyr Thr Thr Leu Ile Ser Glu Arg Leu Asn Thr 
    290                 295                 300                 


Val Thr Val Glu Asn Asp Leu Leu Lys Tyr Ile Lys Asn Lys Ile Pro 
305                 310                 315                 320 


Val Gln Gly Arg Leu Gly Asn Phe Lys Leu Asp Thr Ala Glu Phe Glu 
                325                 330                 335     


Lys Lys Leu Asn Thr Ile Leu Phe Val Leu Asn Glu Ser Asn Leu Ala 
            340                 345                 350         


Gln Arg Phe Ser Ile Leu Val Arg Lys His Tyr Leu Lys Glu Arg Pro 
        355                 360                 365             


Ile Asp Pro Ile Tyr Val Asn Ile Leu Asp Asp Asn Ser Tyr Ser Thr 
    370                 375                 380                 


Leu Glu Gly Phe Asn Ile Ser Ser Gln Gly Ser Asn Asp Phe Gln Gly 
385                 390                 395                 400 


Gln Leu Leu Glu Ser Ser Tyr Phe Glu Lys Ile Glu Ser Asn Ala Leu 
                405                 410                 415     


Arg Ala Phe Ile Lys Ile Cys Pro Arg Asn Gly Leu Leu Tyr Asn Ala 
            420                 425                 430         


Ile Tyr Arg Asn Ser Lys Asn 
        435                 


<210>  41
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Met Lys Leu Glu Ile Asn Lys Phe Asn Tyr Asn Asp Pro Ile Asp Gly 
1               5                   10                  15      


Ile Asn Val Ile Thr Met Arg Pro Pro Arg His Ser Asp Lys Ile Asn 
            20                  25                  30          


Lys Gly Lys Gly Pro Phe Lys Ala Phe Gln Val Ile Lys Asn Ile Trp 
        35                  40                  45              


Ile Val Pro Glu Arg Tyr Asn Phe Thr Asn Asn Thr Asn Asp Leu Asn 
    50                  55                  60                  


Ile Pro Ser Glu Pro Ile Met Glu Ala Asp Ala Ile Tyr Asn Pro Asn 
65                  70                  75                  80  


Tyr Leu Asn Thr Pro Ser Glu Lys Asp Glu Phe Leu Gln Gly Val Ile 
                85                  90                  95      


Lys Val Leu Glu Arg Ile Lys Ser Lys Pro Glu Gly Glu Lys Leu Leu 
            100                 105                 110         


Glu Leu Ile Ser Ser Ser Ile Pro Leu Pro Leu Val Ser Asn Gly Ala 
        115                 120                 125             


Leu Thr Leu Ser Asp Asn Glu Thr Ile Ala Tyr Gln Glu Asn Asn Asn 
    130                 135                 140                 


Ile Val Ser Asn Leu Gln Ala Asn Leu Val Ile Tyr Gly Pro Gly Pro 
145                 150                 155                 160 


Asp Ile Ala Asn Asn Glu Thr Tyr Gly Leu Tyr Ser Thr Pro Ile Ser 
                165                 170                 175     


Asn Gly Glu Gly Thr Leu Ser Glu Val Ser Phe Ser Pro Phe Tyr Leu 
            180                 185                 190         


Lys Pro Phe Asp Glu Ser Tyr Gly Asn Tyr Arg Ser Leu Val Asn Ile 
        195                 200                 205             


Val Asn Lys Phe Val Lys Arg Glu Phe Ala Pro Asp Pro Ala Ser Thr 
    210                 215                 220                 


Leu Met His Glu Leu Val His Val Thr His Asn Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Asn Arg Asn Phe Tyr Tyr Asn Phe Asp Thr Gly Lys Ile Glu Thr Ser 
                245                 250                 255     


Arg Gln Gln Asn Ser Leu Ile Phe Glu Glu Leu Leu Thr Phe Gly Gly 
            260                 265                 270         


Ile Asp Ser Lys Ala Ile Ser Ser Leu Ile Ile Lys Lys Ile Ile Glu 
        275                 280                 285             


Thr Ala Lys Asn Asn Tyr Thr Thr Leu Ile Ser Glu Arg Leu Asn Thr 
    290                 295                 300                 


Val Thr Val Glu Asn Asp Leu Leu Lys Tyr Ile Lys Asn Lys Ile Pro 
305                 310                 315                 320 


Val Gln Gly Arg Leu Gly Asn Phe Lys Leu Asp Thr Ala Glu Phe Glu 
                325                 330                 335     


Lys Lys Leu Asn Thr Ile Leu Phe Val Leu Asn Glu Ser Asn Leu Ala 
            340                 345                 350         


Gln Arg Phe Ser Ile Leu Val Arg Lys His Tyr Leu Lys Glu Arg Pro 
        355                 360                 365             


Ile Asp Pro Ile Tyr Val Asn Ile Leu Asp Asp Asn Ser Tyr Ser Thr 
    370                 375                 380                 


Leu Glu Gly Phe Asn Ile Ser Ser Gln Gly Ser Asn Asp Phe Gln Gly 
385                 390                 395                 400 


Gln Leu Leu Glu Ser Ser Tyr Phe Glu Lys Ile Glu Ser Asn Ala Leu 
                405                 410                 415     


Arg Ala Phe Ile Lys Ile Cys Pro Arg Asn Gly Leu Leu Tyr Asn Ala 
            420                 425                 430         


Ile Tyr Arg Asn Ser Lys Asn 
        435                 


<210>  42
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Met Lys Leu Glu Ile Asn Lys Phe Asn Tyr Asn Asp Pro Ile Asp Gly 
1               5                   10                  15      


Ile Asn Val Ile Thr Met Arg Pro Pro Arg His Ser Asp Lys Ile Asn 
            20                  25                  30          


Lys Gly Lys Gly Pro Phe Lys Ala Phe Gln Val Ile Lys Asn Ile Trp 
        35                  40                  45              


Ile Val Pro Glu Arg Tyr Asn Phe Thr Asn Asn Thr Asn Asp Leu Asn 
    50                  55                  60                  


Ile Pro Ser Glu Pro Ile Met Glu Ala Asp Ala Ile Tyr Asn Pro Asn 
65                  70                  75                  80  


Tyr Leu Asn Thr Pro Ser Glu Lys Asp Glu Phe Leu Gln Gly Val Ile 
                85                  90                  95      


Lys Val Leu Glu Arg Ile Lys Ser Lys Pro Glu Gly Glu Lys Leu Leu 
            100                 105                 110         


Glu Leu Ile Ser Ser Ser Ile Pro Leu Pro Leu Val Ser Asn Gly Ala 
        115                 120                 125             


Leu Thr Leu Ser Asp Asn Glu Thr Ile Ala Tyr Gln Glu Asn Asn Asn 
    130                 135                 140                 


Ile Val Ser Asn Leu Gln Ala Asn Leu Val Ile Tyr Gly Pro Gly Pro 
145                 150                 155                 160 


Asp Ile Ala Asn Asn Glu Thr Tyr Gly Leu Tyr Ser Thr Pro Ile Ser 
                165                 170                 175     


Asn Gly Glu Gly Thr Leu Ser Glu Val Ser Phe Ser Pro Phe Tyr Leu 
            180                 185                 190         


Lys Pro Phe Asp Glu Ser Tyr Gly Asn Tyr Arg Ser Leu Val Asn Ile 
        195                 200                 205             


Val Asn Lys Phe Val Lys Arg Glu Phe Ala Pro Asp Pro Ala Ser Thr 
    210                 215                 220                 


Leu Met His Glu Leu Val His Val Thr His Asn Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Asn Arg Asn Phe Tyr Tyr Asn Phe Asp Thr Gly Lys Ile Glu Thr Ser 
                245                 250                 255     


Arg Gln Gln Asn Ser Leu Ile Phe Glu Glu Leu Leu Thr Phe Gly Gly 
            260                 265                 270         


Ile Asp Ser Lys Ala Ile Ser Ser Leu Ile Ile Lys Lys Ile Ile Glu 
        275                 280                 285             


Thr Ala Lys Asn Asn Tyr Thr Thr Leu Ile Ser Glu Arg Leu Asn Thr 
    290                 295                 300                 


Val Thr Val Glu Asn Asp Leu Leu Lys Tyr Ile Lys Asn Lys Ile Pro 
305                 310                 315                 320 


Val Gln Gly Arg Leu Gly Asn Phe Lys Leu Asp Thr Ala Glu Phe Glu 
                325                 330                 335     


Lys Lys Leu Asn Thr Ile Leu Phe Val Leu Asn Glu Ser Asn Leu Ala 
            340                 345                 350         


Gln Arg Phe Ser Ile Leu Val Arg Lys His Tyr Leu Lys Glu Arg Pro 
        355                 360                 365             


Ile Asp Pro Ile Tyr Val Asn Ile Leu Asp Asp Asn Ser Tyr Ser Thr 
    370                 375                 380                 


Leu Glu Gly Phe Asn Ile Ser Ser Gln Gly Ser Asn Asp Phe Gln Gly 
385                 390                 395                 400 


Gln Leu Leu Glu Ser Ser Tyr Phe Glu Lys Ile Glu Ser Asn Ala Leu 
                405                 410                 415     


Arg Ala Phe Ile Lys Ile Cys Pro Arg Asn Gly Leu Leu Tyr Asn Ala 
            420                 425                 430         


Ile Tyr Leu Asn Ser Lys Asn 
        435                 


<210>  43
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Met Lys Leu Glu Ile Asn Lys Phe Asn Tyr Asn Asp Pro Ile Asp Gly 
1               5                   10                  15      


Ile Asn Val Ile Thr Met Arg Pro Pro Arg His Ser Asp Lys Ile Asn 
            20                  25                  30          


Lys Gly Lys Gly Pro Phe Lys Ala Phe Gln Val Ile Lys Asn Ile Trp 
        35                  40                  45              


Ile Val Pro Glu Arg Tyr Asn Phe Thr Asn Asn Thr Asn Asp Leu Asn 
    50                  55                  60                  


Ile Pro Ser Glu Pro Ile Met Glu Ala Asp Ala Ile Tyr Asn Pro Asn 
65                  70                  75                  80  


Tyr Leu Asn Thr Pro Ser Glu Lys Asp Glu Phe Leu Gln Gly Val Ile 
                85                  90                  95      


Lys Gly Leu Glu Arg Ile Lys Ser Lys Pro Glu Gly Glu Lys Leu Leu 
            100                 105                 110         


Lys Leu Ile Ser Ser Ser Ile Pro Leu Pro Leu Val Ser Asn Gly Ala 
        115                 120                 125             


Leu Thr Leu Ser Asp Asn Glu Thr Ile Ala Tyr Gln Glu Asn Asn Asn 
    130                 135                 140                 


Ile Val Ser Asn Leu Gln Ala Asn Leu Val Ile Tyr Gly Pro Gly Pro 
145                 150                 155                 160 


Asp Ile Ala Asn Asn Glu Thr Tyr Gly Leu Tyr Ser Thr Pro Ile Ser 
                165                 170                 175     


Asn Gly Glu Gly Thr Leu Ser Glu Val Ser Phe Ser Pro Phe Tyr Leu 
            180                 185                 190         


Lys Pro Phe Asp Glu Ser Tyr Gly Asn Tyr Arg Ser Leu Val Asn Ile 
        195                 200                 205             


Val Asn Lys Phe Val Lys Arg Glu Phe Ala Pro Asp Pro Ala Ser Thr 
    210                 215                 220                 


Leu Met His Glu Leu Val His Val Thr His Asn Leu Tyr Gly Ile Ser 
225                 230                 235                 240 


Asn Arg Asn Phe Tyr Tyr Asn Phe Asp Thr Gly Lys Ile Glu Thr Ser 
                245                 250                 255     


Arg Gln Gln Asn Ser Leu Ile Phe Glu Glu Leu Leu Thr Phe Gly Gly 
            260                 265                 270         


Ile Asp Ser Lys Ala Ile Ser Ser Leu Ile Ile Lys Lys Ile Ile Glu 
        275                 280                 285             


Thr Ala Lys Asn Asn Tyr Thr Thr Leu Ile Ser Glu Arg Leu Asn Thr 
    290                 295                 300                 


Val Thr Val Glu Asn Asp Leu Leu Lys Tyr Ile Lys Asn Lys Ile Pro 
305                 310                 315                 320 


Val Gln Gly Arg Leu Gly Asn Phe Lys Leu Asp Thr Ala Glu Phe Glu 
                325                 330                 335     


Lys Lys Leu Asn Thr Ile Leu Phe Val Leu Asn Glu Ser Asn Leu Ala 
            340                 345                 350         


Gln Arg Phe Ser Ile Leu Val Arg Lys His Tyr Leu Lys Glu Arg Pro 
        355                 360                 365             


Ile Asp Pro Ile Tyr Val Asn Ile Leu Asp Asp Asn Ser Tyr Ser Thr 
    370                 375                 380                 


Leu Glu Gly Phe Asn Ile Ser Ser Gln Gly Ser Asn Asp Phe Gln Gly 
385                 390                 395                 400 


Gln Leu Leu Glu Ser Ser Tyr Phe Glu Lys Ile Glu Ser Asn Ala Leu 
                405                 410                 415     


Arg Ala Phe Ile Lys Ile Cys Pro Arg Asn Gly Leu Leu Tyr Asn Ala 
            420                 425                 430         


Ile Tyr Leu Asn Ser Lys Asn 
        435                 


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Gly Leu Val Glu Lys Ile Val Lys Phe Ala Trp Leu Arg Lys Ser 
1               5                   10                  15  


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Gly Leu Val Glu Lys Ile Val Lys Phe 
1               5                   


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Ala Trp Leu Arg Lys Ser 
1               5       


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Val Ala Trp Leu Arg Lys Ser 
1               5           


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Tyr Leu Asn Ser Lys Asn 
1               5       


<210>  49
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Thr Ala Thr Gln Lys Thr Asn Asn Gly Asp Phe Gln His Gly Leu Ala 
1               5                   10                  15      


Arg Pro 
        


<210>  50
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Ala Phe Thr Ala Thr Gln Lys Ser Asn Asn Gly Asp Phe Gln His Gly 
1               5                   10                  15      


Leu Ala Gln Pro 
            20  


<210>  51
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Lys Gly Leu Asp Lys Val Met Glu Thr Gln Ala Gln Val Asp Glu Leu 
1               5                   10                  15      


Lys Gly Ile Met Val Arg Asn Ile Asp Leu Val Ala Gln Arg Gly Glu 
            20                  25                  30          


Arg Leu Glu Leu Leu Ile Asp Lys Thr Glu Asn Leu Val Asp Ser Ser 
        35                  40                  45              


Val Thr Phe Lys Thr Thr Ser Arg Asn Leu Ala Arg 
    50                  55                  60  


<210>  52
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Gly Ser Gly Gly Gly Ala Ser Gly Gly Ala Gly Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Ser Ala Gly Gly Ser Ala Gly Ser Gly Ala Gly Gly 
            20                  25                  


<210>  53
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val 
1               5                   10                  15      


Val Asp Ile Met Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu Lys Arg 
    50                  55                  60  


<210>  54
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Leu Glu Arg Gly Gln 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu Lys Arg 
    50                  55                  60  


<210>  55
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Ala Glu Arg Gly Gln 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu Lys Arg 
    50                  55                  60  


<210>  56
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Ala Glu Arg Gly Glu 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu Lys Arg 
    50                  55                  60  


<210>  57
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Lys Gly Leu Asp Lys Val Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Ala Glu Arg Gly Glu 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Thr Glu Asn Leu Val Asp Ser Ser 
        35                  40                  45              


Val Thr Phe Lys Thr Thr Ser Arg Asn Leu Ala Arg 
    50                  55                  60  


<210>  58
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Lys Gly Leu Asp Lys Val Met Glu Thr Gln Ala Gln Val Asp Glu Leu 
1               5                   10                  15      


Lys Gly Ile Met Val Arg Asn Ile Asp Leu Val Ala Gln Arg Gly Glu 
            20                  25                  30          


Arg Leu Glu Leu Leu Ile Asp Lys Thr Glu Asn Leu Val Asp Ser Ser 
        35                  40                  45              


Val Thr Phe Lys Thr Thr Ser Arg Asn Leu Ala Arg 
    50                  55                  60  


<210>  59
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu Lys Arg 
    50                  55                  60  


<210>  60
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Gly Ser Asn Arg Arg Leu Gln Gln Thr Gln Asn Gln Val Asp Glu Val 
1               5                   10                  15      


Val Asp Ile Met Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu Lys Arg 
    50                  55                  60  


<210>  61
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(2)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (12)..(12)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (15)..(16)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (23)..(23)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (27)..(27)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (30)..(30)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (32)..(32)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (37)..(37)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (39)..(39)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (41)..(41)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (43)..(44)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (50)..(50)
<223>  Xaa can be any amino acid

<400>  61

Xaa Xaa Thr Gln Ala Gln Val Glu Glu Val Lys Xaa Ile Met Xaa Xaa 
1               5                   10                  15      


Asn Val Asp Xaa Val Leu Xaa Arg Gly Glu Xaa Leu Glu Xaa Leu Xaa 
            20                  25                  30          


Asp Lys Thr Glu Xaa Leu Xaa Ala Xaa Ser Xaa Xaa Phe Lys Thr Thr 
        35                  40                  45              


Ser Xaa Lys Leu 
    50          


<210>  62
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Gln Gln Thr Gln Ala Gln Val Glu Glu Val Val Asp Ile Ile Arg Val 
1               5                   10                  15      


Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp 
            20                  25                  30          


Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Ser Ser 
        35                  40                  45              


Ala Ala Lys Leu 
    50          


<210>  63
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Met Glu Thr Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met Val Arg 
1               5                   10                  15      


Asn Ile Asp Leu Val Ala Gln Arg Gly Glu Arg Leu Glu Leu Leu Ile 
            20                  25                  30          


Asp Lys Thr Glu Asn Leu Val Asp Ser Ser Val Thr Phe Lys Thr Thr 
        35                  40                  45              


Ser Arg Asn Leu 
    50          


<210>  64
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Arg Asn Leu Gln Ser Glu Val Glu Gly Val Lys Asn Ile Met Thr Gln 
1               5                   10                  15      


Asn Val Glu Arg Ile Leu Ala Arg Gly Glu Asn Leu Glu His Leu Arg 
            20                  25                  30          


Asn Lys Thr Glu Asp Leu Glu Ala Thr Ser Glu His Phe Lys Thr Thr 
        35                  40                  45              


Ser Gln Lys Val 
    50          


<210>  65
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Gly Gly Asn Asp Arg Val Arg Asn Leu Gln Ser Glu Val Glu Gly Val 
1               5                   10                  15      


Lys Asn Ile Met Thr Gln Asn Val Glu Arg Ile Leu Ala Arg Gly Glu 
            20                  25                  30          


Asn Leu Glu His Leu Arg Asn Lys Thr Glu Asp Leu Glu Ala Thr Ser 
        35                  40                  45              


Glu His Phe Lys Thr Thr Ser Gln Lys Val Ala Arg 
    50                  55                  60  


<210>  66
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val Val Asp Ile Ile 
1               5                   10                  15      


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
            20                  25                  30          


Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu 
        35                  40                  45              


Ser Ser Ala Ala Lys Leu Lys Arg Lys 
    50                  55          


<210>  67
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Lys Val Met Glu Thr Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met 
1               5                   10                  15      


Val Arg Asn Ile Asp Leu Val Ala Gln Arg Gly Glu Arg Leu Glu Leu 
            20                  25                  30          


Leu Ile Asp Lys Thr Glu Asn Leu Val Asp Ser Ser Val Thr Phe Lys 
        35                  40                  45              


Thr Thr Ser Arg Asn Leu Ala Arg Ala 
    50                  55          


<210>  68
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (8)..(8)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (10)..(12)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (14)..(16)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (18)..(18)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (22)..(22)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (25)..(25)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (27)..(27)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (29)..(30)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (32)..(32)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (34)..(37)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (39)..(44)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (46)..(51)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (53)..(53)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (55)..(58)
<223>  Xaa can be any amino acid

<400>  68

Xaa Glx Thr Gln Ala Gln Val Xaa Glu Xaa Xaa Xaa Ile Xaa Xaa Xaa 
1               5                   10                  15      


Asn Xaa Asp Xaa Val Xaa Glx Arg Xaa Glx Xaa Leu Xaa Xaa Leu Xaa 
            20                  25                  30          


Asp Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Leu Xaa Arg Xaa Xaa Xaa Xaa Lys 
    50                  55                  


<210>  69
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Gln Gln Thr Gln Ala Gln Val Glu Glu Val Val Asp Ile Ile Arg Val 
1               5                   10                  15      


Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp 
            20                  25                  30          


Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Ser Ser 
        35                  40                  45              


Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys 
    50                  55                  


<210>  70
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Met Glu Thr Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met Val Arg 
1               5                   10                  15      


Asn Ile Asp Leu Val Ala Gln Arg Gly Glu Arg Leu Glu Leu Leu Ile 
            20                  25                  30          


Asp Lys Thr Glu Asn Leu Val Asp Ser Ser Val Thr Phe Lys Thr Thr 
        35                  40                  45              


Ser Arg Asn Leu Ala Arg Ala Met Cys Met Lys 
    50                  55                  


<210>  71
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val 
1               5                   10                  15      


Val Asp Ile Met Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu Lys Arg Lys Tyr 
    50                  55                  60          


<210>  72
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Ser Glu Asn Lys Gly Leu Asp Lys Val Met Glu Thr Gln Ala Gln Val 
1               5                   10                  15      


Asp Glu Leu Lys Gly Ile Met Val Arg Asn Ile Asp Leu Val Ala Gln 
            20                  25                  30          


Arg Gly Glu Arg Leu Glu Leu Leu Ile Asp Lys Thr Glu Asn Leu Val 
        35                  40                  45              


Asp Ser Ser Val Thr Phe Lys Thr Thr Ser Arg Asn Leu Ala Arg Ala 
    50                  55                  60                  


Met 
65  


<210>  73
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  SITE
<222>  (1)..(3)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (10)..(10)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (12)..(14)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (16)..(18)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (20)..(20)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (22)..(22)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (24)..(24)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (27)..(27)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (29)..(29)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (31)..(32)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (34)..(34)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (36)..(39)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (41)..(46)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (48)..(53)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (55)..(55)
<223>  Xaa can be any amino acid

<220>
<221>  SITE
<222>  (57)..(57)
<223>  Xaa can be any amino acid

<400>  73

Xaa Xaa Xaa Glx Thr Gln Ala Gln Val Xaa Glu Xaa Xaa Xaa Ile Xaa 
1               5                   10                  15      


Xaa Xaa Asn Xaa Asp Xaa Val Xaa Glx Arg Xaa Glx Xaa Leu Xaa Xaa 
            20                  25                  30          


Leu Xaa Asp Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Leu Xaa Arg Xaa 
    50                  55          


<210>  74
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu Lys Arg Lys 
    50                  55                  60      


<210>  75
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75

Gly Gly Asn Asp Arg Val Arg Asn Leu Gln Ser Glu Val Glu Gly Val 
1               5                   10                  15      


Lys Asn Ile Met Thr Gln Asn Val Glu Arg Ile Leu Ala Arg Gly Glu 
            20                  25                  30          


Asn Leu Glu His Leu Arg Asn Lys Thr Glu Asp Leu Glu Ala Thr Ser 
        35                  40                  45              


Glu His Phe Lys Thr Thr Ser Gln Lys Val Ala Arg Lys 
    50                  55                  60      


<210>  76
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn Val 
1               5                   10                  15      


Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg 
            20                  25                  30          


Ala Asp Ala 
        35  


<210>  77
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77

Thr Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met Val Arg Asn Ile 
1               5                   10                  15      


Asp Leu Val Ala Gln Arg Gly Glu Arg Leu Glu Leu Leu Ile Asp Lys 
            20                  25                  30          


Thr Glu Asn 
        35  


<210>  78
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Ile Met Val Arg Asn Ile Asp Leu Val Ala Gln Arg Gly Glu Arg Leu 
1               5                   10                  15      


Glu Leu Leu Ile Asp Lys Thr Glu Asn Leu Val Asp Ser Ser Val Thr 
            20                  25                  30          


Phe Lys Thr 
        35  


<210>  79
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Leu Glu Arg Gly Gln 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu Lys Arg Lys 
    50                  55                  60      


<210>  80
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Ala Glu Arg Gly Gln 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu Lys Arg Lys 
    50                  55                  60      


<210>  81
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Ala Glu Arg Gly Glu 
            20                  25                  30          


Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu Lys Arg Lys 
    50                  55                  60      


<210>  82
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82

Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Val Asp Ile Ile Arg Val Asn Val Asp Lys Val Ala Glu Arg Gly Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
        35                  40                  45              


Ser Gln Phe Glu Ser Ser Ala Ala Lys Leu Lys Arg Lys 
    50                  55                  60      


<210>  83
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83

Lys Gly Leu Asp Lys Val Gln Gln Thr Gln Ala Gln Val Glu Glu Val 
1               5                   10                  15      


Lys Asp Ile Ile Arg Val Asn Val Asp Leu Val Ala Glu Arg Gly Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Ile Asp Arg Thr Glu Asn Leu Val Asp Ser Ser 
        35                  40                  45              


Val Thr Phe Lys Thr Thr Ser Arg Asn Leu Ala Arg Ala 
    50                  55                  60      


<210>  84
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84

Lys Gly Leu Asp Lys Val Met Glu Thr Gln Ala Gln Val Asp Glu Leu 
1               5                   10                  15      


Lys Gly Ile Met Val Arg Asn Ile Asp Leu Val Ala Gln Arg Gly Glu 
            20                  25                  30          


Arg Leu Glu Leu Leu Ile Asp Lys Thr Glu Asn Leu Val Asp Ser Ser 
        35                  40                  45              


Val Thr Phe Lys Thr Thr Ser Arg Asn Leu Ala Arg Ala 
    50                  55                  60      


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85

Leu Glu Arg Gly Glu Lys Leu Asp Asp Leu Val Ser Lys Ser Glu Val 
1               5                   10                  15      


Leu 
    


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86

Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala 
1               5                   10                  15      


Leu 
    


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87

Ile Glu Arg Gly Glu Arg Leu Asp Glu Leu Gln Asp Lys Ser Glu Ser 
1               5                   10                  15      


Leu 
    


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88

Leu Glu Arg Gly Val Lys Leu Ala Glu Leu Gln Gln Arg Ser Asp Gln 
1               5                   10                  15      


Leu 
    


<210>  89
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89

Tyr Arg Asn Ser Lys Asn 
1               5       


<210>  90
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90

Leu Leu Tyr Asn Ala Ile Tyr Arg Asn Ser Lys Asn 
1               5                   10          


<210>  91
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91

Cys Cys Ile Met Pro Phe Thr Ala Thr Gln Lys Thr Asn Asn Gly Asp 
1               5                   10                  15      


Phe Gln His Gly Leu Ala Gln Pro 
            20                  


<210>  92
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92

Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg Ile Met 
1               5                   10                  15      


Glu Lys Ala Asp 
            20  


<210>  93
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93

Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys Ser Ile Glu 
1               5                   10                  15      


Arg Ala Asp Asn 
            20  


<210>  94
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94

Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Ser Ile Met 
1               5                   10                  15      


Glu Lys Ala Asp 
            20  


<210>  95
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95

Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Cys Ser Ile Met 
1               5                   10                  15      


Glu Lys Ala Asp 
            20  


<210>  96
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96

Met Gly Ser Leu Cys Asp Thr Gln Asn Arg Gln Ile Cys Ser Ile Met 
1               5                   10                  15      


Glu Lys Ala Asp 
            20  


<210>  97
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97

Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys Ser Ile Glu 
1               5                   10                  15      


Glu Lys Ala Asp 
            20  


<210>  98
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98

Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Cys Arg Ile Met 
1               5                   10                  15      


Glu Lys Ala Asp 
            20  


