﻿               序列表

<110> 神州细胞工程有限公司

<120> 嵌合的人乳头瘤病毒51型L1蛋白

<130> CIE200056PCT 

<160> 14

<170> BiSSAP 1.3.6

<210> 1
<211> 474
<212> PRT
<213> 智人


<220> 
<223> HPV 51型L1蛋白的1-474氨基酸序列

<400> 1
Met Ala Leu Trp Arg Thr Asn Asp Ser Lys Val Tyr Leu Pro Pro Ala 
1               5                   10                  15      
Pro Val Ser Arg Ile Val Asn Thr Glu Glu Tyr Ile Thr Arg Thr Gly 
            20                  25                  30          
Ile Tyr Tyr Tyr Ala Gly Ser Ser Arg Leu Ile Thr Leu Gly His Pro 
        35                  40                  45              
Tyr Phe Pro Ile Pro Lys Thr Ser Thr Arg Ala Ala Ile Pro Lys Val 
    50                  55                  60                  
Ser Ala Phe Gln Tyr Arg Val Phe Arg Val Gln Leu Pro Asp Pro Asn 
65                  70                  75                  80  
Lys Phe Gly Leu Pro Asp Pro Asn Leu Tyr Asn Pro Asp Thr Asp Arg 
                85                  90                  95      
Leu Val Trp Gly Cys Val Gly Val Glu Val Gly Arg Gly Gln Pro Leu 
            100                 105                 110         
Gly Val Gly Leu Ser Gly His Pro Leu Phe Asn Lys Tyr Asp Asp Thr 
        115                 120                 125             
Glu Asn Ser Arg Ile Ala Asn Gly Asn Ala Gln Gln Asp Val Arg Asp 
    130                 135                 140                 
Asn Thr Ser Val Asp Asn Lys Gln Thr Gln Leu Cys Ile Ile Gly Cys 
145                 150                 155                 160 
Ala Pro Pro Ile Gly Glu His Trp Gly Ile Gly Thr Thr Cys Lys Asn 
                165                 170                 175     
Thr Pro Val Pro Pro Gly Asp Cys Pro Pro Leu Glu Leu Val Ser Ser 
            180                 185                 190         
Val Ile Gln Asp Gly Asp Met Ile Asp Thr Gly Phe Gly Ala Met Asp 
        195                 200                 205             
Phe Ala Ala Leu Gln Ala Thr Lys Ser Asp Val Pro Leu Asp Ile Ser 
    210                 215                 220                 
Gln Ser Val Cys Lys Tyr Pro Asp Tyr Leu Lys Met Ser Ala Asp Thr 
225                 230                 235                 240 
Tyr Gly Asn Ser Met Phe Phe His Leu Arg Arg Glu Gln Ile Phe Ala 
                245                 250                 255     
Arg His Tyr Tyr Asn Lys Leu Val Gly Val Gly Glu Asp Ile Pro Asn 
            260                 265                 270         
Asp Tyr Tyr Ile Lys Gly Ser Gly Asn Gly Arg Asp Pro Ile Glu Ser 
        275                 280                 285             
Tyr Ile Tyr Ser Ala Thr Pro Ser Gly Ser Met Ile Thr Ser Asp Ser 
    290                 295                 300                 
Gln Ile Phe Asn Lys Pro Tyr Trp Leu His Arg Ala Gln Gly His Asn 
305                 310                 315                 320 
Asn Gly Ile Cys Trp Asn Asn Gln Leu Phe Ile Thr Cys Val Asp Thr 
                325                 330                 335     
Thr Arg Ser Thr Asn Leu Thr Ile Ser Thr Ala Thr Ala Ala Val Ser 
            340                 345                 350         
Pro Thr Phe Thr Pro Ser Asn Phe Lys Gln Tyr Ile Arg His Gly Glu 
        355                 360                 365             
Glu Tyr Glu Leu Gln Phe Ile Phe Gln Leu Cys Lys Ile Thr Leu Thr 
    370                 375                 380                 
Thr Glu Val Met Ala Tyr Leu His Thr Met Asp Pro Thr Ile Leu Glu 
385                 390                 395                 400 
Gln Trp Asn Phe Gly Leu Thr Leu Pro Pro Ser Ala Ser Leu Glu Asp 
                405                 410                 415     
Ala Tyr Arg Phe Val Arg Asn Ala Ala Thr Ser Cys Gln Lys Asp Thr 
            420                 425                 430         
Pro Pro Gln Ala Lys Pro Asp Pro Leu Ala Lys Tyr Lys Phe Trp Asp 
        435                 440                 445             
Val Asp Leu Lys Glu Arg Phe Ser Leu Asp Leu Asp Gln Phe Ala Leu 
    450                 455                 460                 
Gly Arg Lys Phe Leu Leu Gln Val Gly Val 
465                 470                 

<210> 2
<211> 26
<212> PRT
<213> 智人


<220> 
<223> HPV 33型L1蛋白的474-499氨基酸序列

<400> 2
Lys Ala Lys Pro Lys Leu Lys Arg Ala Ala Pro Thr Ser Thr Arg Thr 
1               5                   10                  15      
Ser Ser Ala Lys Arg Lys Lys Val Lys Lys 
            20                  25      

<210> 3
<211> 500
<212> PRT
<213> 人工序列


<220> 
<223> 嵌合的HPV 51型L1蛋白的氨基酸序列

<400> 3
Met Ala Leu Trp Arg Thr Asn Asp Ser Lys Val Tyr Leu Pro Pro Ala 
1               5                   10                  15      
Pro Val Ser Arg Ile Val Asn Thr Glu Glu Tyr Ile Thr Arg Thr Gly 
            20                  25                  30          
Ile Tyr Tyr Tyr Ala Gly Ser Ser Arg Leu Ile Thr Leu Gly His Pro 
        35                  40                  45              
Tyr Phe Pro Ile Pro Lys Thr Ser Thr Arg Ala Ala Ile Pro Lys Val 
    50                  55                  60                  
Ser Ala Phe Gln Tyr Arg Val Phe Arg Val Gln Leu Pro Asp Pro Asn 
65                  70                  75                  80  
Lys Phe Gly Leu Pro Asp Pro Asn Leu Tyr Asn Pro Asp Thr Asp Arg 
                85                  90                  95      
Leu Val Trp Gly Cys Val Gly Val Glu Val Gly Arg Gly Gln Pro Leu 
            100                 105                 110         
Gly Val Gly Leu Ser Gly His Pro Leu Phe Asn Lys Tyr Asp Asp Thr 
        115                 120                 125             
Glu Asn Ser Arg Ile Ala Asn Gly Asn Ala Gln Gln Asp Val Arg Asp 
    130                 135                 140                 
Asn Thr Ser Val Asp Asn Lys Gln Thr Gln Leu Cys Ile Ile Gly Cys 
145                 150                 155                 160 
Ala Pro Pro Ile Gly Glu His Trp Gly Ile Gly Thr Thr Cys Lys Asn 
                165                 170                 175     
Thr Pro Val Pro Pro Gly Asp Cys Pro Pro Leu Glu Leu Val Ser Ser 
            180                 185                 190         
Val Ile Gln Asp Gly Asp Met Ile Asp Thr Gly Phe Gly Ala Met Asp 
        195                 200                 205             
Phe Ala Ala Leu Gln Ala Thr Lys Ser Asp Val Pro Leu Asp Ile Ser 
    210                 215                 220                 
Gln Ser Val Cys Lys Tyr Pro Asp Tyr Leu Lys Met Ser Ala Asp Thr 
225                 230                 235                 240 
Tyr Gly Asn Ser Met Phe Phe His Leu Arg Arg Glu Gln Ile Phe Ala 
                245                 250                 255     
Arg His Tyr Tyr Asn Lys Leu Val Gly Val Gly Glu Asp Ile Pro Asn 
            260                 265                 270         
Asp Tyr Tyr Ile Lys Gly Ser Gly Asn Gly Arg Asp Pro Ile Glu Ser 
        275                 280                 285             
Tyr Ile Tyr Ser Ala Thr Pro Ser Gly Ser Met Ile Thr Ser Asp Ser 
    290                 295                 300                 
Gln Ile Phe Asn Lys Pro Tyr Trp Leu His Arg Ala Gln Gly His Asn 
305                 310                 315                 320 
Asn Gly Ile Cys Trp Asn Asn Gln Leu Phe Ile Thr Cys Val Asp Thr 
                325                 330                 335     
Thr Arg Ser Thr Asn Leu Thr Ile Ser Thr Ala Thr Ala Ala Val Ser 
            340                 345                 350         
Pro Thr Phe Thr Pro Ser Asn Phe Lys Gln Tyr Ile Arg His Gly Glu 
        355                 360                 365             
Glu Tyr Glu Leu Gln Phe Ile Phe Gln Leu Cys Lys Ile Thr Leu Thr 
    370                 375                 380                 
Thr Glu Val Met Ala Tyr Leu His Thr Met Asp Pro Thr Ile Leu Glu 
385                 390                 395                 400 
Gln Trp Asn Phe Gly Leu Thr Leu Pro Pro Ser Ala Ser Leu Glu Asp 
                405                 410                 415     
Ala Tyr Arg Phe Val Arg Asn Ala Ala Thr Ser Cys Gln Lys Asp Thr 
            420                 425                 430         
Pro Pro Gln Ala Lys Pro Asp Pro Leu Ala Lys Tyr Lys Phe Trp Asp 
        435                 440                 445             
Val Asp Leu Lys Glu Arg Phe Ser Leu Asp Leu Asp Gln Phe Ala Leu 
    450                 455                 460                 
Gly Arg Lys Phe Leu Leu Gln Val Gly Val Lys Ala Lys Pro Lys Leu 
465                 470                 475                 480 
Lys Arg Ala Ala Pro Thr Ser Thr Arg Thr Ser Ser Ala Lys Arg Lys 
                485                 490                 495     
Lys Val Lys Lys 
            500 

<210> 4
<211> 1504
<212> DNA
<213> 人工序列


<220> 
<223> 嵌合的HPV 51型L1蛋白的核苷酸序列

<400> 4
atggctctgt ggaggaccaa tgacagcaag gtctacctgc ctcctgcccc tgtgagcagg      60

attgtgaaca cagaggaata catcaccagg acaggcatct actactatgc tggctccagc     120

agactgatta ccctgggaca cccatacttt ccaatcccaa agaccagcac cagggctgcc     180

atcccaaagg tgtctgcctt ccaatacagg gtgttcaggg tccaacttcc tgacccaaac     240

aagtttggac tgcctgaccc aaacctctac aaccctgaca cagacagact ggtgtggggc     300

tgtgtgggag tggaggtggg caggggacaa ccactgggag tgggactgtc tggacaccca     360

ctgttcaaca aatatgatga cacagagaac agcaggattg ccaatggcaa tgcccaacag     420

gatgtgaggg acaacacctc tgtggacaac aagcagaccc aactttgtat cattggctgt     480

gcccctccaa ttggagaaca ctggggcatt ggcaccactt gtaagaacac acctgtgcct     540

cctggagact gtcctccatt ggaactggtg tcctctgtga ttcaggatgg agatatgatt     600

gacacaggct ttggagctat ggactttgct gccctccaag ccaccaagtc tgatgtgcca     660

ctggacatca gccagtctgt gtgtaaatac cctgactacc tgaaaatgag tgctgacacc     720

tatggcaaca gtatgttctt ccacctgagg agggaacaga tttttgccag acactactac     780

aacaaactgg tgggagtggg agaggacatc ccaaatgact actacatcaa gggctctggc     840

aatggcaggg acccaattga gtcctacatc tactctgcca caccatctgg cagtatgatt     900

acctctgaca gccagatttt caacaagcca tactggctgc acagggctca aggacacaac     960

aatggcatct gttggaacaa ccaacttttc atcacttgtg tggacaccac caggagcacc    1020

aacctgacca tcagcacagc cacagcagca gtgagcccaa ccttcacacc aagcaacttc    1080

aagcaataca tcagacatgg agaggaatat gaactccaat tcatcttcca actttgtaag    1140

attaccctga ccacagaggt gatggcttac ctgcacacaa tggacccaac catcttggaa    1200

cagtggaact ttggactgac cctgcctcca tctgcctcct tggaggatgc ctacaggttt    1260

gtgaggaatg ctgccacctc ctgtcagaag gacacacctc cacaggctaa gcctgaccca    1320

ctggctaaat acaagttctg ggatgtggac ctgaaagaga ggttctccct ggacctggac    1380

cagtttgccc tgggcaggaa gttcctgctc caagtgggag tcaaagccaa gccaaaactg    1440

aaaagggctg ccccaaccag caccaggacc tcctctgcca agaggaagaa ggtgaagaag    1500

taaa                                                                 1504


<210> 5
<211> 1534
<212> DNA
<213> 人工序列


<220> 
<223> 合成的HPV51L1基因

<400> 5
ctgggtacca tggctctgtg gaggaccaat gacagcaagg tctacctgcc tcctgcccct      60

gtgagcagga ttgtgaacac agaggaatac atcaccagga caggcatcta ctactatgct     120

ggctccagca gactgattac cctgggacac ccatactttc caatcccaaa gaccagcacc     180

agggctgcca tcccaaaggt gtctgccttc caatacaggg tgttcagggt ccaacttcct     240

gacccaaaca agtttggact gcctgaccca aacctctaca accctgacac agacagactg     300

gtgtggggct gtgtgggagt ggaggtgggc aggggacaac cactgggagt gggactgtct     360

ggacacccac tgttcaacaa atatgatgac acagagaaca gcaggattgc caatggcaat     420

gcccaacagg atgtgaggga caacacctct gtggacaaca agcagaccca actttgtatc     480

attggctgtg cccctccaat tggagaacac tggggcattg gcaccacttg taagaacaca     540

cctgtgcctc ctggagactg tcctccattg gaactggtgt cctctgtgat tcaggatgga     600

gatatgattg acacaggctt tggagctatg gactttgctg ccctccaagc caccaagtct     660

gatgtgccac tggacatcag ccagtctgtg tgtaaatacc ctgactacct gaaaatgagt     720

gctgacacct atggcaacag tatgttcttc cacctgagga gggaacagat ttttgccaga     780

cactactaca acaaactggt gggagtggga gaggacatcc caaatgacta ctacatcaag     840

ggctctggca atggcaggga cccaattgag tcctacatct actctgccac accatctggc     900

agtatgatta cctctgacag ccagattttc aacaagccat actggctgca cagggctcaa     960

ggacacaaca atggcatctg ttggaacaac caacttttca tcacttgtgt ggacaccacc    1020

aggagcacca acctgaccat cagcacagcc acagcagcag tgagcccaac cttcacacca    1080

agcaacttca agcaatacat cagacatgga gaggaatatg aactccaatt catcttccaa    1140

ctttgtaaga ttaccctgac cacagaggtg atggcttacc tgcacacaat ggacccaacc    1200

atcttggaac agtggaactt tggactgacc ctgcctccat ctgcctcctt ggaggatgcc    1260

tacaggtttg tgaggaatgc tgccacctcc tgtcagaagg acacacctcc acaggctaag    1320

cctgacccac tggctaaata caagttctgg gatgtggacc tgaaagagag gttctccctg    1380

gacctggacc agtttgccct gggcaggaag ttcctgctcc aagtgggagt ccagaggaag    1440

ccaagacctg gactgaaaag acctgcctcc tctgcctcct cctcctcctc ctcctctgcc    1500

aagaggaaga gggtgaagaa gtaaactcga gctc                                1534


<210> 6
<211> 1519
<212> DNA
<213> 人工序列


<220> 
<223> 合成的HPV33L1基因

<400> 6
ctgggtacca tgagtgtgtg gagaccatct gaggctacag tctacctgcc tcctgtgcct      60

gtgagcaagg tggtgagcac agatgaatat gtgagcagga ccagcatcta ctactatgct     120

ggctccagca gactgctggc tgtgggacac ccatacttca gcatcaagaa cccaaccaat     180

gccaagaaac tgctggtgcc aaaggtgtct ggactccaat acagggtgtt cagggtgaga     240

ctgcctgacc caaacaagtt tggctttcct gacacctcct tctacaaccc tgacacccag     300

agactggtgt gggcttgtgt gggattggag attggcaggg gacaaccact gggagtgggc     360

atctctggac acccactgct gaacaagttt gatgacacag agacaggcaa caaataccct     420

ggacaacctg gagcagacaa cagggagtgt ctgagtatgg actacaagca gacccaactt     480

tgtctgctgg gctgtaagcc tccaacagga gaacactggg gcaagggagt ggcttgtacc     540

aatgctgccc ctgccaatga ctgtcctcca ttggaactga taaacaccat cattgaggat     600

ggagatatgg tggacacagg ctttggctgt atggacttca agaccctcca agccaacaag     660

tctgatgtgc caattgacat ctgtggcagc acttgtaaat accctgacta cctgaaaatg     720

acctctgaac catatggaga ctccctgttc ttcttcctga ggagggaaca gatgtttgtg     780

agacacttct tcaacagggc tggcaccctg ggagaggctg tgcctgatga cctctacatc     840

aagggctctg gcaccacagc cagcatccag tcctctgcct tctttccaac accatctggc     900

agtatggtga cctctgagag ccaacttttc aacaagccat actggctcca aagggctcaa     960

ggacacaaca atggcatctg ttggggcaac caggtgtttg tgacagtggt ggacaccacc    1020

aggagcacca atatgaccct gtgtacccag gtgacctctg acagcaccta caagaatgag    1080

aacttcaagg aatacatcag gcatgtggag gaatatgacc tccaatttgt gttccaactt    1140

tgtaaggtga ccctgacagc agaggtgatg acctacatcc atgctatgaa ccctgacatc    1200

ttggaggact ggcagtttgg actgacacct cctccatctg cctccctcca agacacctac    1260

aggtttgtga ccagccaggc tatcacttgt cagaagacag tgcctccaaa ggagaaggag    1320

gacccactgg gcaaatacac cttctgggag gtggacctga aagagaagtt ctctgctgac    1380

ctggaccagt ttccactggg caggaagttc ctgctccaag caggactgaa agccaagcca    1440

aaactgaaaa gggctgcccc aaccagcacc aggacctcct ctgccaagag gaagaaggtg    1500

aagaagtaaa ctcgagctc                                                 1519


<210> 7
<211> 34
<212> DNA
<213> 人工序列


<220> 
<223> HPV51L1 F1

<400> 7
cttggtacca tggctctgtg gaggaccaat gaca                                 34


<210> 8
<211> 32
<212> DNA
<213> 人工序列


<220> 
<223> HPV51L1 R1

<400> 8
gcttggcttt gactcccact tggagcagga ac                                   32


<210> 9
<211> 1441
<212> DNA
<213> 人工序列


<220> 
<223> HPV51L1扩增序列1

<400> 9
cttggtacca tggctctgtg gaggaccaat gacagcaagg tctacctgcc tcctgcccct      60

gtgagcagga ttgtgaacac agaggaatac atcaccagga caggcatcta ctactatgct     120

ggctccagca gactgattac cctgggacac ccatactttc caatcccaaa gaccagcacc     180

agggctgcca tcccaaaggt gtctgccttc caatacaggg tgttcagggt ccaacttcct     240

gacccaaaca agtttggact gcctgaccca aacctctaca accctgacac agacagactg     300

gtgtggggct gtgtgggagt ggaggtgggc aggggacaac cactgggagt gggactgtct     360

ggacacccac tgttcaacaa atatgatgac acagagaaca gcaggattgc caatggcaat     420

gcccaacagg atgtgaggga caacacctct gtggacaaca agcagaccca actttgtatc     480

attggctgtg cccctccaat tggagaacac tggggcattg gcaccacttg taagaacaca     540

cctgtgcctc ctggagactg tcctccattg gaactggtgt cctctgtgat tcaggatgga     600

gatatgattg acacaggctt tggagctatg gactttgctg ccctccaagc caccaagtct     660

gatgtgccac tggacatcag ccagtctgtg tgtaaatacc ctgactacct gaaaatgagt     720

gctgacacct atggcaacag tatgttcttc cacctgagga gggaacagat ttttgccaga     780

cactactaca acaaactggt gggagtggga gaggacatcc caaatgacta ctacatcaag     840

ggctctggca atggcaggga cccaattgag tcctacatct actctgccac accatctggc     900

agtatgatta cctctgacag ccagattttc aacaagccat actggctgca cagggctcaa     960

ggacacaaca atggcatctg ttggaacaac caacttttca tcacttgtgt ggacaccacc    1020

aggagcacca acctgaccat cagcacagcc acagcagcag tgagcccaac cttcacacca    1080

agcaacttca agcaatacat cagacatgga gaggaatatg aactccaatt catcttccaa    1140

ctttgtaaga ttaccctgac cacagaggtg atggcttacc tgcacacaat ggacccaacc    1200

atcttggaac agtggaactt tggactgacc ctgcctccat ctgcctcctt ggaggatgcc    1260

tacaggtttg tgaggaatgc tgccacctcc tgtcagaagg acacacctcc acaggctaag    1320

cctgacccac tggctaaata caagttctgg gatgtggacc tgaaagagag gttctccctg    1380

gacctggacc agtttgccct gggcaggaag ttcctgctcc aagtgggagt caaagccaag    1440

c                                                                    1441


<210> 10
<211> 35
<212> DNA
<213> 人工序列


<220> 
<223> HPV51L1 F2

<400> 10
agtgggagtc aaagccaagc caaaactgaa aaggg                                35


<210> 11
<211> 36
<212> DNA
<213> 人工序列


<220> 
<223> HPV51L1 R2

<400> 11
ctgtctagat ttacttcttc accttcttcc tcttgg                               36


<210> 12
<211> 101
<212> DNA
<213> 人工序列


<220> 
<223> HPV51L1扩增序列2

<400> 12
agtgggagtc aaagccaagc caaaactgaa aagggctgcc ccaaccagca ccaggacctc     60

ctctgccaag aggaagaagg tgaagaagta aatctagaca g                        101


<210> 13
<211> 38
<212> PRT
<213> 智人


<220> 
<223> HPV 59型L1蛋白的471-508氨基酸序列

<400> 13
Leu Gln Leu Gly Ala Arg Pro Lys Pro Thr Ile Gly Pro Arg Lys Arg 
1               5                   10                  15      
Ala Ala Pro Ala Pro Thr Ser Thr Pro Ser Pro Lys Arg Val Lys Arg 
            20                  25                  30          
Arg Lys Ser Ser Arg Lys 
        35              

<210> 14
<211> 474
<212> PRT
<213> 智人


<220> 
<223> C端截短的HPV16L1（1-474）氨基酸序列

<400> 14
Met Ser Leu Trp Leu Pro Ser Glu Ala Thr Val Tyr Leu Pro Pro Val 
1               5                   10                  15      
Pro Val Ser Lys Val Val Ser Thr Asp Glu Tyr Val Ala Arg Thr Asn 
            20                  25                  30          
Ile Tyr Tyr His Ala Gly Thr Ser Arg Leu Leu Ala Val Gly His Pro 
        35                  40                  45              
Tyr Phe Pro Ile Lys Lys Pro Asn Asn Asn Lys Ile Leu Val Pro Lys 
    50                  55                  60                  
Val Ser Gly Leu Gln Tyr Arg Val Phe Arg Ile His Leu Pro Asp Pro 
65                  70                  75                  80  
Asn Lys Phe Gly Phe Pro Asp Thr Ser Phe Tyr Asn Pro Asp Thr Gln 
                85                  90                  95      
Arg Leu Val Trp Ala Cys Val Gly Val Glu Val Gly Arg Gly Gln Pro 
            100                 105                 110         
Leu Gly Val Gly Ile Ser Gly His Pro Leu Leu Asn Lys Leu Asp Asp 
        115                 120                 125             
Thr Glu Asn Ala Ser Ala Tyr Ala Ala Asn Ala Gly Val Asp Asn Arg 
    130                 135                 140                 
Glu Cys Ile Ser Met Asp Tyr Lys Gln Thr Gln Leu Cys Leu Ile Gly 
145                 150                 155                 160 
Cys Lys Pro Pro Ile Gly Glu His Trp Gly Lys Gly Ser Pro Cys Thr 
                165                 170                 175     
Asn Val Ala Val Asn Pro Gly Asp Cys Pro Pro Leu Glu Leu Ile Asn 
            180                 185                 190         
Thr Val Ile Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met 
        195                 200                 205             
Asp Phe Thr Thr Leu Gln Ala Asn Lys Ser Glu Val Pro Leu Asp Ile 
    210                 215                 220                 
Cys Thr Ser Ile Cys Lys Tyr Pro Asp Tyr Ile Lys Met Val Ser Glu 
225                 230                 235                 240 
Pro Tyr Gly Asp Ser Leu Phe Phe Tyr Leu Arg Arg Glu Gln Met Phe 
                245                 250                 255     
Val Arg His Leu Phe Asn Arg Ala Gly Ala Val Gly Glu Asn Val Pro 
            260                 265                 270         
Asp Asp Leu Tyr Ile Lys Gly Ser Gly Ser Thr Ala Asn Leu Ala Ser 
        275                 280                 285             
Ser Asn Tyr Phe Pro Thr Pro Ser Gly Ser Met Val Thr Ser Asp Ala 
    290                 295                 300                 
Gln Ile Phe Asn Lys Pro Tyr Trp Leu Gln Arg Ala Gln Gly His Asn 
305                 310                 315                 320 
Asn Gly Ile Cys Trp Gly Asn Gln Leu Phe Val Thr Val Val Asp Thr 
                325                 330                 335     
Thr Arg Ser Thr Asn Met Ser Leu Cys Ala Ala Ile Ser Thr Ser Glu 
            340                 345                 350         
Thr Thr Tyr Lys Asn Thr Asn Phe Lys Glu Tyr Leu Arg His Gly Glu 
        355                 360                 365             
Glu Tyr Asp Leu Gln Phe Ile Phe Gln Leu Cys Lys Ile Thr Leu Thr 
    370                 375                 380                 
Ala Asp Val Met Thr Tyr Ile His Ser Met Asn Ser Thr Ile Leu Glu 
385                 390                 395                 400 
Asp Trp Asn Phe Gly Leu Gln Pro Pro Pro Gly Gly Thr Leu Glu Asp 
                405                 410                 415     
Thr Tyr Arg Phe Val Thr Ser Gln Ala Ile Ala Cys Gln Lys His Thr 
            420                 425                 430         
Pro Pro Ala Pro Lys Glu Asp Pro Leu Lys Lys Tyr Thr Phe Trp Glu 
        435                 440                 445             
Val Asn Leu Lys Glu Lys Phe Ser Ala Asp Leu Asp Gln Phe Pro Leu 
    450                 455                 460                 
Gly Arg Lys Phe Leu Leu Gln Ala Gly Leu 
465                 470                 

