                         SEQUENCE LISTING

<110>  JANSSEN BIOTECH, INC.
 
<120>  SYNTHETIC GENETIC ELEMENTS FOR BIOMANUFACTURE

<130>  14620-192-228

<140>
<141>

<150>  US 62/877,577
<151>  2019-07-23

<150>  US 62/877,561
<151>  2019-07-23

<150>  US 62/877,551
<151>  2019-07-23

<150>  US 62/877,540
<151>  2019-07-23

<150>  US 62/877,532
<151>  2019-07-23

<150>  US 62/877,524
<151>  2019-07-23

<150>  US 62/877,516
<151>  2019-07-23

<150>  US 62/877,508
<151>  2019-07-23

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPBetac2 Integrase (NP_046553.1) Protein Sequence

<400>  1

Met Glu Leu Lys Asn Ile Val Asn Ser Tyr Asn Ile Thr Asn Ile Leu 
1               5                   10                  15      


Gly Tyr Leu Arg Arg Ser Arg Gln Asp Met Glu Arg Glu Lys Arg Thr 
            20                  25                  30          


Gly Glu Asp Thr Leu Thr Glu Gln Lys Glu Leu Met Asn Lys Ile Leu 
        35                  40                  45              


Thr Ala Ile Glu Ile Pro Tyr Glu Leu Lys Met Glu Ile Gly Ser Gly 
    50                  55                  60                  


Glu Ser Ile Asp Gly Arg Pro Val Phe Lys Glu Cys Leu Lys Asp Leu 
65                  70                  75                  80  


Glu Glu Gly Lys Tyr Gln Ala Ile Ala Val Lys Glu Ile Thr Arg Leu 
                85                  90                  95      


Ser Arg Gly Ser Tyr Ser Asp Ala Gly Gln Ile Val Asn Leu Leu Gln 
            100                 105                 110         


Ser Lys Arg Leu Ile Ile Ile Thr Pro Tyr Lys Val Tyr Asp Pro Arg 
        115                 120                 125             


Asn Pro Val Asp Met Arg Gln Ile Arg Phe Glu Leu Phe Met Ala Arg 
    130                 135                 140                 


Glu Glu Phe Glu Met Thr Arg Glu Arg Met Thr Gly Ala Lys Tyr Thr 
145                 150                 155                 160 


Tyr Ala Ala Gln Gly Lys Trp Ile Ser Gly Leu Ala Pro Tyr Gly Tyr 
                165                 170                 175     


Gln Leu Asn Lys Lys Thr Ser Lys Leu Asp Pro Val Glu Asp Glu Ala 
            180                 185                 190         


Lys Val Val Gln Leu Ile Phe Asn Ile Phe Leu Asn Gly Leu Asn Gly 
        195                 200                 205             


Lys Asp Tyr Ser Tyr Thr Ala Ile Ala Ser His Leu Thr Asn Leu Gln 
    210                 215                 220                 


Ile Pro Thr Pro Ser Gly Lys Lys Arg Trp Asn Gln Tyr Thr Ile Lys 
225                 230                 235                 240 


Ala Ile Leu Gln Asn Glu Val Tyr Ile Gly Thr Val Lys Tyr Lys Val 
                245                 250                 255     


Arg Glu Lys Thr Lys Asp Gly Lys Arg Thr Ile Arg Pro Glu Lys Glu 
            260                 265                 270         


Gln Ile Val Val Gln Asp Ala His Ala Pro Ile Ile Asp Lys Glu Gln 
        275                 280                 285             


Phe Gln Gln Ser Gln Val Lys Ile Ala Asn Lys Val Pro Leu Leu Pro 
    290                 295                 300                 


Asn Lys Asp Glu Phe Glu Leu Ser Glu Leu Ala Gly Val Cys Thr Cys 
305                 310                 315                 320 


Ser Lys Cys Gly Glu Pro Leu Ser Lys Tyr Glu Ser Lys Arg Ile Arg 
                325                 330                 335     


Lys Asn Lys Asp Gly Thr Glu Ser Val Tyr His Val Lys Ser Leu Thr 
            340                 345                 350         


Cys Lys Lys Asn Lys Cys Thr Tyr Val Arg Tyr Asn Asp Val Glu Asn 
        355                 360                 365             


Ala Ile Leu Asp Tyr Leu Ser Ser Leu Asn Asp Leu Asn Asp Ser Thr 
    370                 375                 380                 


Leu Thr Lys His Ile Asn Ser Met Leu Ser Lys Tyr Glu Asp Asp Asn 
385                 390                 395                 400 


Ser Asn Met Lys Thr Lys Lys Gln Met Ser Glu His Leu Ser Gln Lys 
                405                 410                 415     


Glu Lys Glu Leu Lys Asn Lys Glu Asn Phe Ile Phe Asp Lys Tyr Glu 
            420                 425                 430         


Ser Gly Ile Tyr Ser Asp Glu Leu Phe Leu Lys Arg Lys Ala Ala Leu 
        435                 440                 445             


Asp Glu Glu Phe Lys Glu Leu Gln Asn Ala Lys Asn Glu Leu Asn Gly 
    450                 455                 460                 


Leu Gln Asp Thr Gln Ser Glu Ile Asp Ser Asn Thr Val Arg Asn Asn 
465                 470                 475                 480 


Ile Asn Lys Ile Ile Asp Gln Tyr His Ile Glu Ser Ser Ser Glu Lys 
                485                 490                 495     


Lys Asn Glu Leu Leu Arg Met Val Leu Lys Asp Val Ile Val Asn Met 
            500                 505                 510         


Thr Gln Lys Arg Lys Gly Pro Ile Pro Ala Gln Phe Glu Ile Thr Pro 
        515                 520                 525             


Ile Leu Arg Phe Asn Phe Ile Phe Asp Leu Thr Ala Thr Asn Ser Phe 
    530                 535                 540                 


His 
545 


<210>  2
<211>  535
<212>  PRT
<213>  Artificial sequence

<220>
<223>  SR21 Recombinase (WP_029708089.1) Protein Sequence

<400>  2

Met Glu Leu Lys His Ile Val Asn Ser Tyr Asn Val Thr Lys Ile Ile 
1               5                   10                  15      


Gly Tyr Leu Arg Arg Ser Arg Gln Asp Val Glu Arg Glu Lys Arg Thr 
            20                  25                  30          


Gly Glu Asp Thr Leu Thr Glu Gln Lys Glu Leu Met Asn Lys Ile Leu 
        35                  40                  45              


Thr Gly Ile Glu Ile Pro Tyr Glu Thr Arg Thr Glu Ile Gly Ser Gly 
    50                  55                  60                  


Glu Ser Ile Glu Gly Arg Pro Val Phe Lys Ser Cys Leu Ala Asp Leu 
65                  70                  75                  80  


Arg Ser Gly Lys Phe Gln Ala Ile Ala Val Lys Glu Ile Thr Arg Leu 
                85                  90                  95      


Ser Arg Gly Ser Tyr Ser Asp Ala Gly Glu Ile Val Asn Leu Leu Asn 
            100                 105                 110         


Glu Lys Arg Ile Ile Ile Ile Thr Pro Tyr Lys Ile Tyr Asp Pro Arg 
        115                 120                 125             


Asn Pro Val Asp Ala Arg Gln Ile Arg Phe Glu Leu Phe Met Ala Arg 
    130                 135                 140                 


Glu Glu Phe Glu Met Thr Arg Glu Arg Met Asn Gly Ala Lys Phe Thr 
145                 150                 155                 160 


Tyr Ala Ala Gln Gly Lys Trp Ile Ser Gly Leu Ala Pro Phe Gly Tyr 
                165                 170                 175     


Lys Leu Asn Lys Arg Thr Ser Arg Leu Glu Pro Ser Asp Glu Asp Lys 
            180                 185                 190         


Val Val Val Lys Leu Ile Phe Asp Ile Phe Leu Asn Gly Leu Asp Gly 
        195                 200                 205             


Lys Asp Leu Ser Tyr Thr Ala Ile Ala Thr His Leu Ser Lys Leu Gln 
    210                 215                 220                 


Phe Thr Thr Pro Arg Gly Gly Lys Arg Trp Ser Lys Asp Thr Val Arg 
225                 230                 235                 240 


Lys Ile Leu Gln Asn Glu Ala Tyr Met Gly Arg Val Arg Tyr Lys Ala 
                245                 250                 255     


Arg Glu Thr Thr Lys Asp Gly Lys Lys Val Phe Arg Pro Glu Ser Glu 
            260                 265                 270         


His Ile Val Val Asp Asp Ala His Glu Pro Ile Ile Asn Lys Glu Asp 
        275                 280                 285             


Phe Glu Ala Val Gln Glu Lys Ile Lys Asn Lys Val Pro Leu Leu Pro 
    290                 295                 300                 


Val Val Thr Ser Tyr Glu Pro Asn Glu Leu Ala Gly Ile Cys Val Cys 
305                 310                 315                 320 


Ser Val Cys Gly Lys Ser Leu Gln Lys Phe Glu Ser Glu Tyr Asn Arg 
                325                 330                 335     


Lys Asn Lys Asp Gly Thr Ser Ser Tyr Phe His Val Lys Leu Leu Ile 
            340                 345                 350         


Cys Lys Ile Asn Lys Cys Thr Ser Val Arg Tyr Glu Tyr Val Glu Glu 
        355                 360                 365             


Ala Ile Leu Glu Tyr Leu Glu Gln Leu Ile Ala Leu Glu Asn Asn Lys 
    370                 375                 380                 


Leu Lys Ala Ile Ile Glu Lys Ser Met Glu Ala Ala Glu Thr Asn Asn 
385                 390                 395                 400 


Ser Glu Lys Thr Ser Glu Gln Met Leu Val Gln Ala Asn Gln Lys Gln 
                405                 410                 415     


Lys Glu Leu Glu Asn Lys Leu Thr Phe Ile Phe Glu Lys Phe Glu Ser 
            420                 425                 430         


Gly Ile Tyr Thr Asp Glu Met Phe Leu Gln Arg Lys Ala Ala Ile Glu 
        435                 440                 445             


Lys Glu Val Ala Asp Ile Lys Lys Leu Lys Gln Glu Leu Ser Met Thr 
    450                 455                 460                 


Phe Glu Val Lys Glu Lys Asp Val Asn Glu Phe Arg Val Asn Ile Ser 
465                 470                 475                 480 


Asp Val Val Lys Phe Tyr Lys Glu Ser Lys Ser Arg Gly Leu Lys Asn 
                485                 490                 495     


Glu Lys Leu Arg Ser Ile Phe Asp Phe Ile Val Leu Glu Met Thr Glu 
            500                 505                 510         


Lys Arg Arg Gly Pro Ile Pro Ala Lys Phe Asn Ile Tyr Pro Val Leu 
        515                 520                 525             


Arg Ile Pro Ser Val Val Asn 
    530                 535 


<210>  3
<211>  1608
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SR21 Recombinase DNA Sequence

<400>  3
ttggaattaa aacacattgt caattcctat aatgtgacta aaattattgg ctatttgaga       60

cgttctagac aagatgttga aagagagaag cgtactggtg aagatacttt gacagaacaa      120

aaagaactta tgaataaaat attgactggg attgaaatac cgtacgaaac aagaactgag      180

atcggttctg gtgaaagcat tgaaggaaga ccagtgttta aaagttgctt agctgatctg      240

aggtctggaa aatttcaagc aattgctgta aaagaaataa ctcgtcttag tcgtggtagt      300

tacagtgatg ctggtgaaat cgtcaatctt ctaaatgaaa aaaggattat cataattaca      360

ccatataaaa tatatgatcc aagaaatcct gttgatgctc gtcaaattag atttgagcta      420

tttatggcta gagaagaatt tgaaatgaca agagaaagaa tgaatggtgc caagtttact      480

tatgctgcac aaggaaaatg gatttctggt ttagcaccat ttggctataa attaaataag      540

cgtacatctc gcctcgaacc atcggatgaa gacaaagttg tggtaaagtt gatatttgac      600

attttcttaa atggccttga tggtaaagat ttaagttata cagctattgc aactcatctt      660

tctaaacttc aattcactac cccaagggga ggaaaaagat ggagtaagga cactgttaga      720

aaaattcttc aaaatgaagc ctatatggga agggttaggt ataaagcaag agaaaccaca      780

aaagatggaa aaaaagtctt ccgacctgaa agtgaacata ttgttgtaga tgatgcccac      840

gaaccaataa taaataaaga ggactttgaa gctgttcaag aaaagattaa aaataaagtg      900

cctctgcttc cagtcgtaac atcttatgaa cctaatgaat tagcgggaat atgtgtatgc      960

tctgtctgtg gaaaatcact tcaaaaattt gaatccgaat acaataggaa aaacaaagat     1020

gggacttcca gctattttca cgtgaagtta ttgatttgca aaatcaacaa gtgcacatca     1080

gtgagatatg agtatgttga agaagcaatt ttggagtatc ttgagcagtt gattgcttta     1140

gaaaataata aactaaaggc tataattgaa aaatctatgg aagcagcaga aactaacaat     1200

tcagaaaaga caagtgagca aatgctagta caagcaaacc aaaaacagaa agagctcgaa     1260

aacaaattga catttatttt tgaaaaattt gaatctggaa tttatacaga tgaaatgttt     1320

ttgcaaagga aagcagctat tgaaaaagaa gtagctgaca ttaaaaaatt gaaacaagaa     1380

cttagcatga catttgaagt taaagagaaa gatgttaatg aatttagggt taacatatca     1440

gatgtagtta aattttataa agaatctaaa agtagaggat taaaaaatga aaagttgaga     1500

tccatttttg actttatagt attagaaatg acagagaaaa gacgaggccc catccctgct     1560

aagttcaata tttatccggt tttgcgaatt ccgagtgtag ttaattaa                  1608


<210>  4
<211>  188
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bacillus safensis Fairview strain Pre-insertion locus 
       (gi|640668059:c464939-464752)

<400>  4
agataatccg ttcgaagctg ttcaaacgaa tatcatcggc gggcagcacg tcattgaagc       60

cgcaattgaa catgaagtga gtcatgtcgt caacatctcc actgacaaag cggtttctcc      120

aacgaatgcc atgggtgcaa caaaattgat ttcagaaaaa ctatttttcc aagcaaacga      180

aagtattc                                                               188


<210>  5
<211>  120
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Right Prophage-Host DNA Junction, Bacillus safensis strain 
       CCMA-560

<400>  5
tttgcgaatt ccgagtgtag ttaattaagt atcatgataa actgacaaag cggtttctcc       60

aacgaatgcc atgggtgcaa caaaattgat ttcagaaaaa ctatttttcc aagcaaacga      120


<210>  6
<211>  158
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Left Prophage-Host DNA Junction, Bacillus safensis strain 
       CCMA-560

<400>  6
tatcatcggc gggcagcacg tcattgaagc cgctctcgaa catgaagtga gtcatgtcgt       60

caacatttca actgacaaag cggtatatca agatacttaa tacatgataa caaaaaaaga      120

agcctacata ttggcttctt ttataattat atttgcta                              158


<210>  7
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SR21 Recombinase AttP reconstructed from Bacillus safensis strain
       CCMA-560 (artificial sequence)

<400>  7
aattaagtat catgataaac tgacaaagcg gtatatcaag atacttaata                  50


<210>  8
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SR21 Recombinase AttB reconstructed from Bacillus safensis strain
       CCMA-560

<400>  8
cgtcaacatt tcaactgaca aagcggtttc tccaacgaat                             40


<210>  9
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SR21 Recombinase AttB reconstructed from Bacillus safensis strain
       Fairview

<400>  9
cgtcaacatc tccactgaca aagcggtttc tccaacgaat                             40


<210>  10
<211>  4532
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P175- SR21 Mammalian expression vector

<400>  10
taactataac ggtcctaagg tagcgaagct cttcagatgg acagtcagac tgaagagcct       60

ctcttaaggt agctcgagga gcttggccca ttgcatacgt tgtatccata tcataatatg      120

tacatttata ttggctcatg tccaacatta ccgccatgtt gacattgatt attgactagt      180

tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt      240

acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg      300

tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg      360

gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt      420

acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg      480

accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg      540

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt      600

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      660

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      720

tgggaggtct atataagcag agctcgttta gtgaaccgtc ggcgcgccgc caccatggaa      780

ttaaaacaca ttgtcaattc ctataatgtg actaaaatta ttggctattt gagacgttcc      840

agacaagatg ttgaaagaga gaagcgtact ggtgaagata ctttgacaga acaaaaagaa      900

cttatgaata aaatattgac tgggattgaa ataccgtacg aaacaagaac tgagatcggt      960

tctggtgaaa gcattgaagg aagaccagtg tttaaaagtt gcttagctga tctgaggtct     1020

ggaaaatttc aagcaattgc tgtaaaagaa ataactcgtc ttagtcgtgg tagttacagt     1080

gatgctggtg aaatcgtcaa tcttctaaat gaaaaaagga ttatcataat tacaccatat     1140

aaaatatatg atccaagaaa tcctgttgat gctcgtcaaa ttagatttga gctatttatg     1200

gctagagaag aatttgaaat gacaagagaa agaatgaatg gtgccaagtt tacttatgct     1260

gcacaaggaa aatggatttc tggtttagca ccatttggct ataaattaaa taagcgtaca     1320

tctcgcctcg aaccatcgga tgaagacaaa gttgtggtaa agttgatatt tgacattttc     1380

ttaaatggcc ttgatggtaa agatttaagt tatacagcta ttgcaactca tctttctaaa     1440

cttcaattca ctaccccaag gggaggaaaa agatggagta aggacactgt tagaaaaatt     1500

cttcaaaatg aagcctatat gggaagggtt aggtataaag caagagaaac cacaaaagat     1560

ggaaaaaaag tcttccgacc tgaaagtgaa catattgttg tagatgatgc ccacgaacca     1620

ataataaata aagaggactt tgaagctgtt caagaaaaga ttaaaaataa agtgcctctg     1680

cttccagtcg taacatctta tgaacctaat gaattagcgg gaatatgtgt atgctctgtc     1740

tgtggaaaat cacttcaaaa atttgaatcc gaatacaata ggaaaaacaa agatgggact     1800

tccagctatt ttcacgtgaa gttattgatt tgcaaaatca acaagtgcac atcagtgaga     1860

tatgagtatg ttgaagaagc aattttggag tatcttgagc agttgattgc tttagaaaat     1920

aataaactaa aggctataat tgaaaaatct atggaagcag cagaaactaa caattcagaa     1980

aagacaagtg agcaaatgct agtacaagca aaccaaaaac agaaagaact cgaaaacaaa     2040

ttgacattta tttttgaaaa atttgaatct ggaatttata cagatgaaat gtttttgcaa     2100

aggaaagcag ctattgaaaa agaagtagct gacattaaaa aattgaaaca agaacttagc     2160

atgacatttg aagttaaaga gaaagatgtt aatgaattta gggttaacat atcagatgta     2220

gttaaatttt ataaagaatc taaaagtaga ggattaaaaa atgaaaagtt gagatccatt     2280

tttgacttta tagtattaga aatgacagag aaaagacgag gccccatccc tgctaagttc     2340

aatatttatc cggttttgcg aatcccgagt gtagttaatt aatctagaga tacattgatg     2400

agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg     2460

atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt     2520

gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa agcaagtaaa     2580

acctctacaa atgtggtatg gctgattatg atcgcggccg caataaagat cccgggtagg     2640

gataacaggg taatgctctt cagatggaca gtcagactga agagctggca aacagctatt     2700

atgggtatta tgggtgacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     2760

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     2820

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     2880

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     2940

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     3000

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     3060

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     3120

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     3180

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     3240

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     3300

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     3360

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     3420

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     3480

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     3540

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     3600

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     3660

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     3720

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     3780

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     3840

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     3900

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     3960

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     4020

aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     4080

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     4140

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     4200

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     4260

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     4320

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     4380

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     4440

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     4500

cctggccttt tgctggcctt ttgctcacat gt                                   4532


<210>  11
<211>  9555
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P41- SR21 recombinase reporter plasmid

<400>  11
taactataac ggtcctaagg tagcgaagct cttcagatgg acagtcagac tgaagagcct       60

ctcttaaggt agctcgagga gcttggccca ttgcatacgt tgtatccata tcataatatg      120

tacatttata ttggctcatg tccaacatta ccgccatgtt gacattgatt attgactagt      180

tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt      240

acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg      300

tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg      360

gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt      420

acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg      480

accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg      540

gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt      600

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      660

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      720

tgggaggtct atataagcag agctcgttta gtgaaccgtc ggcgcgcccg tcaacatctc      780

cactgacaaa gcggtttctc caacgaatgg atccttacac ggcgatcttg ccgcccttct      840

tggccttaat gagaatctcg cggatcttgc gggcgtccaa cttgccggtc agtcctttag      900

gcacctcgtc cacgaacaca acaccaccgc gcagcttctt ggcggttgta acctggctgg      960

ccacatagtc cacgatctcc ttctcggtca tggttttacc gtgttccagc acgacgactg     1020

cggcgggcag ctcgccggca tcgtcgtcgg gcaggccggc gaccccggcg tcgaagatgt     1080

tggggtgttg cagcaggatg ctctccagtt cggctggggc tacctggtag cccttgtatt     1140

tgatcaggct cttcagccgg tccacgatga agaagtgctc gtcctcgtcc cagtaggcga     1200

tgtcgccgct gtgcagccag ccgtccttgt cgatgagagc gtttgtagcc tcggggttgt     1260

taacgtagcc gctcatgatc atggggccac ggacgcacag ctcgccgcgc tggttcacac     1320

ccagtgtctt accggtgtcc aagtccacca ccttagcctc gaagaagggc accaccttgc     1380

ctactgcgcc aggcttgtcg tccccttcgg gggtgatcag aatggcgctg gttgtttctg     1440

tcaggccgta gccctggcgg atgcctggta ggtggaagcg tttggccacg gcctcaccta     1500

cctccttgct gagcggcgcc ccgccgctgg cgatctcgtg caagttgctt aggtcgtact     1560

tgtcgatgag agtgctctta gcgaagaagc taaatagtgt gggcaccagc agggcagatt     1620

gaatcttata gtcttgcaag ctgcgcaaga atagctcctc ctcgaagcgg tacatgagca     1680

cgacccgaaa gccgcagatc aagtagccca gcgtggtgaa catgccgaag ccgtggtgaa     1740

atggcaccac gctgaggata gcggtgtcgg ggatgatctg gttgccgaag atggggtcgc     1800

gggcatgact gaatcggaca caagcggtgc ggtgcggtag ggctacgccc ttgggcaatc     1860

cggtactgcc actactgttc atgatcaggg cgatggtttt gtcccggtcg aagctctcgg     1920

gcacgaagtc gtactcgttg aagccgggtg gcaaatggga agtcacgaag gtgtacatgc     1980

tttggaagcc ctggtagtcg gtcttgctat ccatgatgat gatcttttgt atgatcggta     2040

gcttcttttg cacgttgagg atcttttgca gccctttctt gctcacgaat acgacggtgg     2100

gctggctgat gcccatgctg ttcagcagct cgcgctcgtt gtagatgtcg ttagctgggg     2160

ccacagccac accgatgaac agggcaccca acacgggcat gaagaactgc aagctattct     2220

cgctgcacac cacgatccga tggtttgtat tcagcccata gcgcttcata gcttctgcca     2280

gccgaacgct catctcgaag tactcggcgt aggtaatgtc cacctcgata tgtgcgtcgg     2340

taaaggcgat ggtgccgggc accagggcgt agcgcttcat ggctttgtgc agctgctcgc     2400

cggcggtccc gtcttcgagt gggtagaatg gcgctggacc cttcttaatg tttttggcat     2460

cttccatagg tccagggttg gactccacgt ctcccgccaa cttgagaagg tcaaaattca     2520

aagtctgttt cactccgctt cccttgtaca gctcgtccat gccgccggtg gagtggcggc     2580

cctcggcgcg ttcgtactgt tccacgatgg tgtagtcctc gttgtgggag gtgatgtcca     2640

acttgatgtt gacgttgtag gcgccgggca gctgcacggg cttcttggcc ttgtaggtgg     2700

tcttgacctc agcgtcgtag tggccgccgt ccttcagctt cagcctctgc ttgatctcgc     2760

ccttcagggc gccgtcctcg gggtacatcc gctcggagga ggcctcccag cccatggtct     2820

tcttctgcat tacggggccg tcggagggga agttggtgcc gcgcagcttc accttgtaga     2880

tgaactcgcc gtcctgcagg gaggagtcct gggtcacggt caccacgccg ccgtcctcga     2940

agttcatcac gcgctcccac ttgaagccct cggggaagga cagcttcaag tagtcgggga     3000

tgtcggcggg gtgcttcacg taggccttgg agccgtacat gaactgaggg gacaggatgt     3060

cccaggcgaa gggcaggggg ccacccttgg tcaccttcag cttggcggtc tgggtgccct     3120

cgtaggggcg gccctcgccc tcgccctcga tctcgaactc gtggccgttc acggagccct     3180

ccatgtgcac cttgaagcgc atgaactcct tgatgatggc catgttatcc tcctcgccct     3240

tgctcaccat ggtggcgtcg actattaagt atcttgatat accgctttgt cagtttatca     3300

tgatacttaa tttctagaga tacattgatg agtttggaca aaccacaact agaatgcagt     3360

gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa     3420

gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg     3480

aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg     3540

atcgcggccg ccgtgaggct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt     3600

ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg     3660

ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga     3720

accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag     3780

aacacaggta agtgccgtgt gtggttcccg cgggcctggc ctctttacgg gttatggccc     3840

ttgcgtgcct tgaattactt ccacgcccct ggctgcagta cgtgattctt gatcccgagc     3900

ttcgggttgg aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc     3960

gtgcttgagt tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc     4020

ttcgcgcctg tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg     4080

ctgcgacgct ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg     4140

gtatttcggt ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgctcatgtt     4200

cggcgaggcg gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg     4260

gccggcctgc tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa     4320

ggctggcccg gtcggcacca gttgcgtgag cggaaagatg gccgcttccc ggccctgctg     4380

cagggagctc aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac     4440

aaaggaaaag ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg     4500

cgccgtccag gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg     4560

gggaggggtt ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc     4620

cagcttggca cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt     4680

tcattctcaa gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgag     4740

ccaccatgga gagcgacgag agcggcctgc ccgccatgga gatcgagtgc cgcatcaccg     4800

gcaccctgaa cggcgtggag ttcgagctgg tgggcggcgg agagggcacc cccgagcagg     4860

gccgcatgac caacaagatg aagagcacca aaggcgccct gaccttcagc ccctacctgc     4920

tgagccacgt gatgggctac ggcttctacc acttcggcac ctaccccagc ggctacgaga     4980

accccttcct gcacgccatc aacaacggcg gctacaccaa cacccgcatc gagaagtacg     5040

aggacggcgg cgtgctgcac gtgagcttca gctaccgcta cgaggccggc cgcgtgatcg     5100

gcgacttcaa ggtgatgggc accggcttcc ccgaggacag cgtgatcttc accgacaaga     5160

tcatccgcag caacgccacc gtggagcacc tgcaccccat gggcgataac gatctggatg     5220

gcagcttcac ccgcaccttc agcctgcgcg acggcggcta ctacagctcc gtggtggaca     5280

gccacatgca cttcaagagc gccatccacc ccagcatcct gcagaacggg ggacccatgt     5340

tcgccttccg ccgcgtggag gaggatcaca gcaacaccga gctgggcatc gtggagtacc     5400

agcacgcctt caagaccccg gatgcagatg ccggtgaaga aggaagcgga gctactaact     5460

tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacctatg gcttccaagg     5520

tgtacgaccc cgagcaacgc aaacgcatga tcactgggcc tcagtggtgg gctcgctgca     5580

agcaaatgaa cgtgctggac tccttcatca actactatga ttccgagaag cacgccgaga     5640

acgccgtgat ttttctgcat ggtaacgctg cctccagcta cctgtggagg cacgtcgtgc     5700

ctcacatcga gcccgtggct agatgcatca tccctgatct gatcggaatg ggtaagtccg     5760

gcaagagcgg gaatggctca tatcgcctcc tggatcacta caagtacctc accgcttggt     5820

tcgagctgct gaaccttcca aagaaaatca tctttgtggg ccacgactgg ggggcttgtc     5880

tggcctttca ctactcctac gagcaccaag acaagatcaa ggccatcgtc catgctgaga     5940

gtgtcgtgga cgtgatcgag tcctgggacg agtggcctga catcgaggag gacatcgccc     6000

tgatcaagag cgaagagggc gagaaaatgg tgcttgagaa taacttcttc gtcgagacca     6060

tgctcccaag caagatcatg cggaaactgg agcctgagga gttcgctgcc tacctggagc     6120

cattcaagga gaagggcgag gttagacggc ctaccctctc ctggcctcgc gagatccctc     6180

tcgttaaggg aggcaagccc gatgtcgtcc agattgtccg caactacaac gcctaccttc     6240

gggccagcga cgatctgcct aagatgttca tcgagtccga ccctgggttc ttttccaacg     6300

ctattgtcga gggagctaag aagttcccta acaccgagtt cgtgaaggtg aagggcctcc     6360

acttcagcca ggaggacgct ccagatgaaa tgggtaagta catcaagagc ttcgtggagc     6420

gcgtgctgaa gaacgagcag taagctcact gcccatgatg cagagctttc aaggataggc     6480

tttattctgc aagcaatcaa ataataaatc tattctgcta agagatcaca catggttgtc     6540

ttcagttctt tttttatgtc tttttaaata tatgagccac aaagggtttt atgttgaggg     6600

atgtgtttat gtgtatttat acatggctat gtgtgtttgt gtcatgtgca cactccacac     6660

ttttttgttt acgttagatg tgggttttga tgagcaaata aaagaactag gcaataaaga     6720

aacttgtaca tgggagttct gcaagtggga gtaaaaggtg caggagaaat ctggttggaa     6780

gaaagacctc tataggacag gactcctcag aaacagatgt tttggaagag atggggaaag     6840

gttcagtgaa gggggctgaa cccccttccc tggattgcag cacagcagcg aggaaggggc     6900

tcaacgaaga aaaagtgttc ctagctttag gaagtcaagg tttaggcagg gatagccatt     6960

ctattttatt aggggcaata ctatttccaa cggcatctgg cttttctcag cccttgtgag     7020

gctctacagg gaggttgagg tgttagagat cagagcagga aacaggtttt tctttccacg     7080

gtaactacaa tgaagtgatc cttactttac taaggaactt ttcattttaa gtgttgacgc     7140

atgcctaaag aggtgaaatt aatcccatac ccttaagtct acagactggt cacagcattt     7200

caaggaggag acctcattgt aagctactag ggaggtgggg acttaggtga aggaaatgag     7260

ccagcagaag ctcacaagtc agcatcagcg tgtcatgtct cagcagcaga acagcacggt     7320

cagatgaaaa tatagtgtga agaatttgta taacattaat tgagaaggca gattcactgg     7380

agttcttata taattgaaag ttaatgcacg ttaataagca agagtttagt ttaatgtgat     7440

ggtgttatga acttaacgct tgtgtctcca gaaaattcac atgctgaatc cccaactccc     7500

aattggctcc atttgtgggg gaggctttgg aaaagtaatc aggtttagag gggctcatga     7560

gagcagatcc ccatcataga attattttcc tcatcagaag cagagagatt agccatttct     7620

cttccttctg gtgaggacac agtgggaagt cagccacctt agggataaca gggtaatgct     7680

cttcagatgg acagtcagac tgaagagctg gcaaacagct attatgggta ttatgggtga     7740

cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa     7800

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt     7860

gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg     7920

cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag     7980

atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg     8040

agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg     8100

gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt     8160

ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga     8220

cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac     8280

ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc     8340

atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc     8400

gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac     8460

tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag     8520

gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg     8580

gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta     8640

tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg     8700

ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata     8760

tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt     8820

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc     8880

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct     8940

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa     9000

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag     9060

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc     9120

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg     9180

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca     9240

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat     9300

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     9360

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     9420

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     9480

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc     9540

cttttgctca catgt                                                      9555


<210>  12
<211>  14985
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P439, Episomal REP/CAP + Transgene Plasmid


<220>
<221>  misc_feature
<222>  (2103)..(2137)
<223>  SEQ ID NO:14 Upstream half of beta-Actin intron

<220>
<221>  misc_feature
<222>  (2144)..(2398)
<223>  5' end of the stop cassette

<220>
<221>  misc_feature
<222>  (4069)..(4287)
<223>  3' end of stop cassette

<220>
<221>  misc_feature
<222>  (4295)..(4370)
<223>  SEQ ID NO:15 Downstream half of beta-Actin intron

<220>
<221>  misc_feature
<222>  (7984)..(8124)
<223>  Left Inverted Terminal Repeat (ITR)

<220>
<221>  misc_feature
<222>  (11067)..(11207)
<223>  Right Inverted Terminal Repeat (ITR)

<400>  12
taactataac ggtcctaagg tagcgaagat atccgatcaa gaaagcactc cgggctccag       60

aaggagcctt ccaggccagc tttgagcata agctgctgat gagcagtgag tgtcttgagt      120

agtgttcagg gcagcatgtt accattcatg cttgacttct agccagtgtg acgagaggct      180

ggagtcaggt ctctagagag ttgagcagct ccagccttag atctcccagt cttatgcggt      240

gtgcccattc gctttgtgtc tgcagtcccc tggccacacc cagtaacagt tctgggatct      300

atgggagtag cttccttagt gagctttccc ttcaaatact ttgcaaccag gtagagaagt      360

ttggagtgaa ggttttgttc ttcgtttctt cacaatatgg atatgcatct tcttttgaaa      420

atgttaaagt aaattacctc tcttttcaga tactgtcttc atgcgaactt ggtatcctgt      480

ttccatccca gccttctata acccagtaac atcttttttg aaaccagtgg gtgagaaaga      540

cacctggtca ggaacgcgga ccacaggaca actcaggctc acccacggca tcagactaaa      600

ggcaaacaag gactctgtat aaagtaccgg tggcatgtgt attagtggag atgcagcctg      660

tgctctgcag acagggagtc acacagacac ttttctataa tttcttaagt gctttgaatg      720

ttcaagtaga aagtctaaca ttaaatttga ttgaacaatt gtatattcat ggaatatttt      780

ggaacggaat accaaaaaat ggcaatagtg gttctttctg gatggaagac aaacttttct      840

tctttaaaat aaattttatt ttatatattt gaggttgacc acatgacctt aaggatacat      900

atagacagta aactggttac tacagtgaag caaattaaca tatctaccat cgtacatagt      960

tacatttttt tgtgtgacag gaacagctaa aatctacgta tttaacaaaa ctcctaaaga     1020

caatacattt ttattaacta tagccctcat gatgtacatt agatcctctc ttaaggtagc     1080

ccgaataaaa atagaaaaac aacaaatgtt aattttctat ttttatttgg tgtcgtactc     1140

aatccataat cgtcacaagc gttatagttt aagtacaaca atgtcgtcac cttgttggtg     1200

taattaggtt tacgccaaca gggtgataac aggcgcgccg gtcctgtatt agaggtcacg     1260

tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta agcccgagtg     1320

agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc atgccggggt     1380

tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc ggcatttctg     1440

acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat tctgacatgg     1500

atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag cgcgactttc     1560

tgacggaatg gcgccgtgtg agtaaggccc cggaggccct tttctttgtg caatttgaga     1620

agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg aaatccatgg     1680

ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt taccgcggga     1740

tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc gccggaggcg     1800

ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa acccagcctg     1860

agctccagtg ggcgtggact aatatggaac agtatttaag cgcctgtttg aatctcacgg     1920

agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag gagcagaaca     1980

aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact tcagccaggt     2040

acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag cagtggatcc     2100

aggtgggtgt ctttcctgcc tgagctgacc tgggcagacg cgtaattaag tatcatgata     2160

aactgacaaa gcggtatatc aagatactta atacatatgg tcctgtaaaa gtttaatgtg     2220

taagaagtat ttgttataaa agataaatat tcagaatctt ctttttaatt cctgatttta     2280

tttctatagg actgaaagac ttgctcgaga tgtcatgaag gagatgggag gccatcacat     2340

tctcacttca ctgcagctca acgtccccaa ttctaccggg taggggaggc gcttttccca     2400

aggcagtctg gagcatgcgc tttagcagcc ccgctgggca cttggcgcta cacaagtggc     2460

ctctggcctc gcacacattc cacatccacc ggtaggcgcc aaccggctcc gttctttggt     2520

ggccccttcg cgccaccttc tactcctccc ctagtcagga agttcccccc cgccccgcag     2580

ctcgcgtcgt gcaggacgtg acaaatggaa gtagcacgtc tcactagtct cgtgcagatg     2640

gacagcaccg ctgagcaatg gaagcgggta ggcctttggg gcagcggcca atagcagctt     2700

tgctccttcg ctttctgggc tcagaggctg ggaaggggtg ggtccggggg cgggctcagg     2760

ggcgggctca ggggcggggc gggcgcccga aggtcctccg gaggcccggc attctgcacg     2820

cttcaaaagc gcacgtctgc cgcgctgttc tcctcttcct catctccggg cctttcgacc     2880

tagcgggcag tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg     2940

ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc     3000

acacaggaaa cagctgccac catgattgaa caagatggat tgcacgcagg ttctccggcc     3060

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     3120

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     3180

tccggtgccc tgaatgaact gcaagacgag gcagcgcggc tatcgtggct ggccacgacg     3240

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3300

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3360

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3420

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3480

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3540

ctcaaggcga gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3600

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3660

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3720

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3780

atcgccttct atcgccttct tgacgagttc ttctgagata cattgatgag tttggacaaa     3840

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     3900

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     3960

tgtttcgggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     4020

gtggtatggc tgattatgat cgcatagtgt taccatcaac caccttaact tcatttttct     4080

tattcaatac ctaggtaggt agatgctaga ttctggaaat aaaatatgag tctcaagtgg     4140

tccttgtcct ctctcccagt caaattctga atctagttgg caagattctg aaatcaaggc     4200

atataatcag taataagtga tgatagaagg gtatatagaa ggctagccgt caacatctcc     4260

actgacaaag cggtttctcc aacgaattat cgattcggct gtggggtcct gtggtgtgtg     4320

gggagctgtc acatccaggg tcctcactgc ctgtcccctt ccctcctcag gaggaccagg     4380

cctcatacat ctccttcaat gcggcctcca actcgcggtc ccaaattaag gctgccttgg     4440

acaatgcggg aaagattatg agcctgacta aaaccgcccc cgactacctg gtgggccagc     4500

agcccgtgga ggacatttcc agcaatcgga tttataaaat tttggaacta aacgggtacg     4560

atccccaata tgcggcttcc gtctttctgg gatgggccac gaaaaagttc ggcaagagga     4620

acaccatctg gctgtttggg cctgcaacta ccgggaagac caacatcgcg gaggccatag     4680

cccacactgt gcccttctac gggtgcgtaa actggaccaa tgagaacttt cccttcaacg     4740

actgtgtcga caagatggtg atctggtggg aggaggggaa gatgaccgcc aaggtcgtgg     4800

agtcggccaa agccattctc ggaggaagca aggtgcgcgt ggaccagaaa tgcaagtcct     4860

cggcccagat agacccgact cccgtgatcg tcacctccaa caccaacatg tgcgccgtga     4920

ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt gcaagaccgg atgttcaaat     4980

ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag gaagtcaaag     5040

actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgagttc tacgtcaaaa     5100

agggtggagc caagaaaaga cccgccccca gtgacgcaga tataagtgag cccaaacggg     5160

tgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc aactacgcag     5220

acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg tttccctgca     5280

gacaatgcga gagaatgaat cagaattcaa atatctgctt cactcacgga cagaaagact     5340

gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa aaggcgtatc     5400

agaaactgtg ctacattcat catatcatgg gaaaggtgcc agacgcttgc actgcctgcg     5460

atctggtcaa tgtggatttg gatgactgca tctttgaaca ataaatgatt taaatcaggt     5520

atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga agggattcgc     5580

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac     5640

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac     5700

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac     5760

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc     5820

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag     5880

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct     5940

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc     6000

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag     6060

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct     6120

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga     6180

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc     6240

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc     6300

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc     6360

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga     6420

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt     6480

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     6540

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     6600

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     6660

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     6720

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     6780

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     6840

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     6900

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     6960

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     7020

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     7080

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     7140

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     7200

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     7260

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     7320

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     7380

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     7440

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     7500

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     7560

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     7620

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     7680

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta attgcttgtt     7740

aatcaataaa ccgtttaatt cgtttcagtt gaactttggt ctctgcggtt taaacggtcc     7800

tgtattagag gtcacgtgag tgttttgcga cattttgcga caccatgtgg tcacgctggg     7860

tatttaagcc cgagtgagca cgcagggtct ccattttgaa gcgggaggtt tgaacgcgcg     7920

cggccgcccg aataaaaata gaaaaacaac aaatgttaat tttctatttt tatttggtct     7980

agacctgcag gcagctgcgc gctcgctcgc tcactgaggc cgcccgggca aagcccgggc     8040

gtcgggcgac ctttggtcgc ccggcctcag tgagcgagcg agcgcgcaga gagggagtgg     8100

ccaactccat cactaggggt tccttctaga cgtgaggctc cggtgcccgt cagtgggcag     8160

agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg     8220

cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt     8280

ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc     8340

gcaacgggtt tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc     8400

tctttacggg ttatggccct tgcgtgcctt gaattacttc cacgcccctg gctgcagtac     8460

gtgattcttg atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct     8520

taaggagccc cttcgcctcg tgcttgagtt gaggcctggc ctgggcgctg gggccgccgc     8580

gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt     8640

taaaattttt gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg     8700

ggccaagatc tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt     8760

gcgtcccagc gctcatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga     8820

cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc     8880

gccccgccct gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg     8940

ccgcttcccg gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg     9000

gcgggtgagt cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt     9060

gactccacgg agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt     9120

acgtcgtctt taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg     9180

gtggagactg aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt     9240

tttgagtttg gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt     9300

ccatttcagg tgtcgtgagc caccatggtg agcaagggcg aggaggataa catggccatc     9360

atcaaggagt tcatgcgctt caaggtgcac atggagggct ccgtgaacgg ccacgagttc     9420

gagatcgagg gcgagggcga gggccgcccc tacgagggca cccagaccgc caagctgaag     9480

gtgaccaagg gtggccccct gcccttcgcc tgggacatcc tgtcccctca gttcatgtac     9540

ggctccaagg cctacgtgaa gcaccccgcc gacatccccg actacttgaa gctgtccttc     9600

cccgagggct tcaagtggga gcgcgtgatg aacttcgagg acggcggcgt ggtgaccgtg     9660

acccaggact cctccctgca ggacggcgag ttcatctaca aggtgaagct gcgcggcacc     9720

aacttcccct ccgacggccc cgtaatgcag aagaagacca tgggctggga ggcctcctcc     9780

gagcggatgt accccgagga cggcgccctg aagggcgaga tcaagcagag gctgaagctg     9840

aaggacggcg gccactacga cgctgaggtc aagaccacct acaaggccaa gaagcccgtg     9900

cagctgcccg gcgcctacaa cgtcaacatc aagttggaca tcacctccca caacgaggac     9960

tacaccatcg tggaacagta cgaacgcgcc gagggccgcc actccaccgg cggcatggac    10020

gagctgtaca agggaagcgg acagtgtact aattatgctc tcttgaaatt ggctggagat    10080

gttgagagca accctggacc tatggcgacc cgcagccctg gcgtcgtgat tagtgatgat    10140

gaacccggtt atgaccttga tttattttgc atacctaatc attatgctga ggatttggaa    10200

agggtgttta ttcctcatgg actaattatg gacaggactg aacgtcttgc tcgagatgtg    10260

atgaaggaga tgggaggcca tcacattgta gccctctgtg tgctcaaggg gggctataaa    10320

ttctttgctg acctgctgga ttacatcaaa gcactgaata gaaatagtga tagatccatt    10380

cctatgactg tagattttat cagactgaag agctattgta atgaccagtc aacaggggac    10440

ataaaagtaa ttggtggaga tgatctctca actttaactg gaaagaatgt cttgattgtg    10500

gaagatataa ttgacactgg caaaacaatg cagactttgc tttccttggt caggcagtat    10560

aatccaaaga tggtcaaggt cgctagcttg ctggtgaaaa ggaccccacg aagtgttgga    10620

tataagccag actttgttgg atttgaaatt ccagacaagt ttgttgtagg atatgccctt    10680

gactataatg aatacttcag ggatttgaat catgtttgtg tcattagtga aactggaaaa    10740

gcaaaataca aagcctaaac gcgtggggga ggctaactga aacacggaag gagacaatac    10800

cggaaggaac ccgcgctatg acggcaataa aaagacagaa taaaacgcac ggtgttgggt    10860

cgtttgttca taaacgcggg gttcggtccc agggctggca ctctgtcgat accccaccga    10920

gaccccattg gggccaatac gcccgcgttt cttccttttc cccaccccac cccccaagtt    10980

cgggtgaagg cccagggctc gcagccaacg tcggggcggc aggccctgcc atagccatct    11040

atgtcgggtg cggagaaaga ggtaatagga acccctagtg atggagttgg ccactccctc    11100

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt    11160

tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcaggtag ggataacagg    11220

gtaatacttg aattttcaag tataaagtct agtgctaaat ttaatttgaa caactgtata    11280

gtttttgctg gttgggggaa ggaaaaaaaa tggtggcagt gtttttttca gaattagaag    11340

tgaaatgaaa acttgttgtg tgtgaggatt tctaatgcca tgtggtggtt gcatactgag    11400

tgaagccggt gagcattctg ccatgtcacc ccctcgtgct cagtaatgta ctttacagaa    11460

atcctaaact caaaagattg atataaacca tgcttcttgt gtatatccgg tctcttctct    11520

gggtagtctc actcagcctg catttctgcc atcccttgtc ctctggcccc cgtcgcccag    11580

atatctggca aacagctatt atgggtatta tgggtttcag ggagtggcgc agctgcttca    11640

tccccgtggc ccgttgctcg cgtttgctgg cggtgtcccc ggaagaaata tatttgcatg    11700

tctttagttc tatgatgaca caaaccccgc ccagcgtctt gtcattggcg aaaacacgca    11760

gatgcagtcg gggcggcgcg gtcccaggtc cacttcgcat attaaggtga cgcgtgtggc    11820

ctcgaacaca gagcgacggc caccatgacc gagtacaagc ccacggtgcg cctcgccacc    11880

cgcgacgacg tcccccgggc cgtacgcacc ctcgccgccg cgttcgccga ctaccccgcc    11940

acgcgccaca ccgttgaccc ggaccgccac atcgagcggg tcaccgagct gcaagaactc    12000

ttcctcacgc gcgtcgggct cgacatcggc aaggtgtggg tcgcggacga cggcgccgcg    12060

gtggcggtct ggaccacgcc ggagagcgtc gaagcggggg cggtgttcgc cgagatcggc    12120

ccgcgcatgg ccgagttgag cggttcccgg ctggccgcgc agcaacagat ggaaggcctc    12180

ctggcgccgc accggcccaa ggagcccgcg tggttcctgg ccaccgtcgg cgtctcgccc    12240

gaccaccagg gcaagggtct gggcagcgcc gtcgtgctcc ccggagtgga ggcggccgag    12300

cgcgccgggg tgcccgcctt cctggagacc tccgcgcccc gcaacctccc cttctacgag    12360

cggctcggct tcaccgtcac cgccgacgtc gaggtgcccg aaggaccgcg cacctggtgc    12420

atgacccgca agcccggtgc ctgatgtgcc ttctagttgc cagccatctg ttgtttgccc    12480

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa    12540

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg    12600

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg    12660

ctctatggtc ccccttatta accctaaacg ggtagcatat gcttcccggg tagtagtata    12720

tactatccag actaacccta attcaatagc atatgttacc caacgggaag catatgctat    12780

cgaattaggg ttagtaaaag ggtcctaagg aacagcgatc tggatagcat atgctatcct    12840

aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagcat aggctatcct    12900

aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat atgctatcct    12960

aatttatatc tgggtagcat aggctatcct aatctatatc tgggtagcat atgctatcct    13020

aatctatatc tgggtagtat atgctatcct aatctgtatc cgggtagcat atgctatcct    13080

catgcatata cagtcagcat atgataccca gtagtagagt gggagtgcta tcctttgcat    13140

atgccgccac ctcccaagga ttatgggtga cgtcaggtgg cacttttcgg ggaaatgtgc    13200

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac    13260

aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt    13320

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag    13380

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg    13440

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa    13500

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc    13560

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag    13620

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa    13680

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc    13740

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg    13800

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa    13860

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa    13920

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg    13980

gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag    14040

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg    14100

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt    14160

ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt    14220

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac    14280

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag    14340

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg    14400

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca    14460

gagcgcagat accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga    14520

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca    14580

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc    14640

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca    14700

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa    14760

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc    14820

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc    14880

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg    14940

cctttttacg gttcctggcc ttttgctggc cttttgctca catgt                    14985


<210>  13
<211>  4409
<212>  DNA
<213>  Artificial sequence

<220>
<223>  REP2/CAP9 Sequence Prior to Inserting STOP Cassette

<400>  13
ggtcctgtat tagaggtcac gtgagtgttt tgcgacattt tgcgacacca tgtggtcacg       60

ctgggtattt aagcccgagt gagcacgcag ggtctccatt ttgaagcggg aggtttgaac      120

gcgcagccgc catgccgggg ttttacgaga ttgtgattaa ggtccccagc gaccttgacg      180

agcatctgcc cggcatttct gacagctttg tgaactgggt ggccgagaag gaatgggagt      240

tgccgccaga ttctgacatg gatctgaatc tgattgagca ggcacccctg accgtggccg      300

agaagctgca gcgcgacttt ctgacggaat ggcgccgtgt gagtaaggcc ccggaggccc      360

ttttctttgt gcaatttgag aagggagaga gctacttcca catgcacgtg ctcgtggaaa      420

ccaccggggt gaaatccatg gttttgggac gtttcctgag tcagattcgc gaaaaactga      480

ttcagagaat ttaccgcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga      540

ccagaaatgg cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact      600

tgctccccaa aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa      660

gcgcctgttt gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt      720

cgcagacgca ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca      780

gatcaaaaac ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta      840

cctcggagaa gcagtggatc caggaggacc aggcctcata catctccttc aatgcggcct      900

ccaactcgcg gtcccaaatt aaggctgcct tggacaatgc gggaaagatt atgagcctga      960

ctaaaaccgc ccccgactac ctggtgggcc agcagcccgt ggaggacatt tccagcaatc     1020

ggatttataa aattttggaa ctaaacgggt acgatcccca atatgcggct tccgtctttc     1080

tgggatgggc cacgaaaaag ttcggcaaga ggaacaccat ctggctgttt gggcctgcaa     1140

ctaccgggaa gaccaacatc gcggaggcca tagcccacac tgtgcccttc tacgggtgcg     1200

taaactggac caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatctggt     1260

gggaggaggg gaagatgacc gccaaggtcg tggagtcggc caaagccatt ctcggaggaa     1320

gcaaggtgcg cgtggaccag aaatgcaagt cctcggccca gatagacccg actcccgtga     1380

tcgtcacctc caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac     1440

accagcagcc gttgcaagac cggatgttca aatttgaact cacccgccgt ctggatcatg     1500

actttgggaa ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg     1560

tggttgaggt ggagcatgag ttctacgtca aaaagggtgg agccaagaaa agacccgccc     1620

ccagtgacgc agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga     1680

cgtcagacgc ggaagcttcg atcaactacg cagacaggta ccaaaacaaa tgttctcgtc     1740

acgtgggcat gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcagaatt     1800

caaatatctg cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat     1860

ctcaacccgt ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca     1920

tgggaaaggt gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact     1980

gcatctttga acaataaatg atttaaatca ggtatggctg ccgatggtta tcttccagat     2040

tggctcgagg acaaccttag tgaagggatt cgcgagtggt gggctttgaa acctggagcc     2100

cctcaaccca aggcaaatca acaacatcaa gacaacgctc gaggtcttgt gcttccgggt     2160

tacaaatacc ttggacccgg caacggactc gacaaggggg agccggtcaa cgcagcagac     2220

gcggcggccc tcgagcacga caaggcctac gaccagcagc tcaaggccgg agacaacccg     2280

tacctcaagt acaaccacgc cgacgccgag ttccaggagc ggctcaaaga agatacgtct     2340

tttgggggca acctcgggcg agcagtcttc caggccaaaa agaggcttct tgaacctctt     2400

ggtctggttg aggaagcggc taagacggct cctggaaaga agaggcctgt agagcagtct     2460

cctcaggaac cggactcctc cgcgggtatt ggcaaatcgg gtgcacagcc cgctaaaaag     2520

agactcaatt tcggtcagac tggcgacaca gagtcagtcc cagaccctca accaatcgga     2580

gaacctcccg cagccccctc aggtgtggga tctcttacaa tggcttcagg tggtggcgca     2640

ccagtggcag acaataacga aggtgccgat ggagtgggta gttcctcggg aaattggcat     2700

tgcgattccc aatggctggg ggacagagtc atcaccacca gcacccgaac ctgggccctg     2760

cccacctaca acaatcacct ctacaagcaa atctccaaca gcacatctgg aggatcttca     2820

aatgacaacg cctacttcgg ctacagcacc ccctgggggt attttgactt caacagattc     2880

cactgccact tctcaccacg tgactggcag cgactcatca acaacaactg gggattccgg     2940

cctaagcgac tcaacttcaa gctcttcaac attcaggtca aagaggttac ggacaacaat     3000

ggagtcaaga ccatcgccaa taaccttacc agcacggtcc aggtcttcac ggactcagac     3060

tatcagctcc cgtacgtgct cgggtcggct cacgagggct gcctcccgcc gttcccagcg     3120

gacgttttca tgattcctca gtacgggtat ctgacgctta atgatggaag ccaggccgtg     3180

ggtcgttcgt ccttttactg cctggaatat ttcccgtcgc aaatgctaag aacgggtaac     3240

aacttccagt tcagctacga gtttgagaac gtacctttcc atagcagcta cgctcacagc     3300

caaagcctgg accgactaat gaatccactc atcgaccaat acttgtacta tctctcaaag     3360

actattaacg gttctggaca gaatcaacaa acgctaaaat tcagtgtggc cggacccagc     3420

aacatggctg tccagggaag aaactacata cctggaccca gctaccgaca acaacgtgtc     3480

tcaaccactg tgactcaaaa caacaacagc gaatttgctt ggcctggagc ttcttcttgg     3540

gctctcaatg gacgtaatag cttgatgaat cctggacctg ctatggccag ccacaaagaa     3600

ggagaggacc gtttctttcc tttgtctgga tctttaattt ttggcaaaca aggaactgga     3660

agagacaacg tggatgcgga caaagtcatg ataaccaacg aagaagaaat taaaactact     3720

aacccggtag caacggagtc ctatggacaa gtggccacaa accaccagag tgcccaagca     3780

caggcgcaga ccggctgggt tcaaaaccaa ggaatacttc cgggtatggt ttggcaggac     3840

agagatgtgt acctgcaagg acccatttgg gccaaaattc ctcacacgga cggcaacttt     3900

cacccttctc cgctgatggg agggtttgga atgaagcacc cgcctcctca gatcctcatc     3960

aaaaacacac ctgtacctgc ggatcctcca acggccttca acaaggacaa gctgaactct     4020

ttcatcaccc agtattctac tggccaagtc agcgtggaga tcgagtggga gctgcagaag     4080

gaaaacagca agcgctggaa cccggagatc cagtacactt ccaactatta caagtctaat     4140

aatgttgaat ttgctgttaa tactgaaggt gtatatagtg aaccccgccc cattggcacc     4200

agatacctga ctcgtaatct gtaattgctt gttaatcaat aaaccgttta attcgtttca     4260

gttgaacttt ggtctctgcg gtttaaacgg tcctgtatta gaggtcacgt gagtgttttg     4320

cgacattttg cgacaccatg tggtcacgct gggtatttaa gcccgagtga gcacgcaggg     4380

tctccatttt gaagcgggag gtttgaacg                                       4409


<210>  14
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Upstream half of beta-Actin Intron

<400>  14
gtgggtgtct ttcctgcctg agctgacctg ggcag                                  35


<210>  15
<211>  76
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Downstream half of beta-Actin intron

<400>  15
tcggctgtgg ggtcctgtgg tgtgtgggga gctgtcacat ccagggtcct cactgcctgt       60

ccccttccct cctcag                                                       76


<210>  16
<211>  2144
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Transcriptional STOP cassette

<400>  16
aattaagtat catgataaac tgacaaagcg gtatatcaag atacttaata catatggtcc       60

tgtaaaagtt taatgtgtaa gaagtatttg ttataaaaga taaatattca gaatcttctt      120

tttaattcct gattttattt ctataggact gaaagacttg ctcgagatgt catgaaggag      180

atgggaggcc atcacattct cacttcactg cagctcaacg tccccaattc taccgggtag      240

gggaggcgct tttcccaagg cagtctggag catgcgcttt agcagccccg ctgggcactt      300

ggcgctacac aagtggcctc tggcctcgca cacattccac atccaccggt aggcgccaac      360

cggctccgtt ctttggtggc cccttcgcgc caccttctac tcctccccta gtcaggaagt      420

tcccccccgc cccgcagctc gcgtcgtgca ggacgtgaca aatggaagta gcacgtctca      480

ctagtctcgt gcagatggac agcaccgctg agcaatggaa gcgggtaggc ctttggggca      540

gcggccaata gcagctttgc tccttcgctt tctgggctca gaggctggga aggggtgggt      600

ccgggggcgg gctcaggggc gggctcaggg gcggggcggg cgcccgaagg tcctccggag      660

gcccggcatt ctgcacgctt caaaagcgca cgtctgccgc gctgttctcc tcttcctcat      720

ctccgggcct ttcgacctag cgggcagtga gcgcaacgca attaatgtga gttagctcac      780

tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt      840

gagcggataa caatttcaca caggaaacag ctgccaccat gattgaacaa gatggattgc      900

acgcaggttc tccggccgct tgggtggaga ggctattcgg ctatgactgg gcacaacaga      960

caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt     1020

ttgtcaagac cgacctgtcc ggtgccctga atgaactgca agacgaggca gcgcggctat     1080

cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc actgaagcgg     1140

gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca tctcaccttg     1200

ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat acgcttgatc     1260

cggctacctg cccattcgac caccaagcga aacatcgcat cgagcgagca cgtactcgga     1320

tggaagccgg tcttgtcgat caggatgatc tggacgaaga gcatcagggg ctcgcgccag     1380

ccgaactgtt cgccaggctc aaggcgagca tgcccgacgg cgaggatctc gtcgtgaccc     1440

atggcgatgc ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct ggattcatcg     1500

actgtggccg gctgggtgtg gcggaccgct atcaggacat agcgttggct acccgtgata     1560

ttgctgaaga gcttggcggc gaatgggctg accgcttcct cgtgctttac ggtatcgccg     1620

ctcccgattc gcagcgcatc gccttctatc gccttcttga cgagttcttc tgagatacat     1680

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat     1740

ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa     1800

caattgcatt cattttatgt ttcgggttca gggggaggtg tgggaggttt tttaaagcaa     1860

gtaaaacctc tacaaatgtg gtatggctga ttatgatcgc atagtgttac catcaaccac     1920

cttaacttca tttttcttat tcaataccta ggtaggtaga tgctagattc tggaaataaa     1980

atatgagtct caagtggtcc ttgtcctctc tcccagtcaa attctgaatc tagttggcaa     2040

gattctgaaa tcaaggcata taatcagtaa taagtgatga tagaagggta tatagaaggc     2100

tagccgtcaa catctccact gacaaagcgg tttctccaac gaat                      2144


<210>  17
<211>  170
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Strong Splice Acceptor

<400>  17
gtcctgtaaa agtttaatgt gtaagaagta tttgttataa aagataaata ttcagaatct       60

tctttttaat tcctgatttt atttctatag gactgaaaga cttgctcgag atgtcatgaa      120

ggagatggga ggccatcaca ttctcacttc actgcagctc aacgtcccca                 170


<210>  18
<211>  1672
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neomycin/ Kanamycin Resistance Gene

<400>  18
attctaccgg gtaggggagg cgcttttccc aaggcagtct ggagcatgcg ctttagcagc       60

cccgctgggc acttggcgct acacaagtgg cctctggcct cgcacacatt ccacatccac      120

cggtaggcgc caaccggctc cgttctttgg tggccccttc gcgccacctt ctactcctcc      180

cctagtcagg aagttccccc ccgccccgca gctcgcgtcg tgcaggacgt gacaaatgga      240

agtagcacgt ctcactagtc tcgtgcagat ggacagcacc gctgagcaat ggaagcgggt      300

aggcctttgg ggcagcggcc aatagcagct ttgctccttc gctttctggg ctcagaggct      360

gggaaggggt gggtccgggg gcgggctcag gggcgggctc aggggcgggg cgggcgcccg      420

aaggtcctcc ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg ccgcgctgtt      480

ctcctcttcc tcatctccgg gcctttcgac ctagcgggca gtgagcgcaa cgcaattaat      540

gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg      600

ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctgcca ccatgattga      660

acaagatgga ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga      720

ctgggcacaa cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg      780

gcgcccggtt ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaagacga      840

ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt      900

tgtcactgaa gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct      960

gtcatctcac cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct     1020

gcatacgctt gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg     1080

agcacgtact cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca     1140

ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg agcatgcccg acggcgagga     1200

tctcgtcgtg acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt     1260

ttctggattc atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt     1320

ggctacccgt gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct     1380

ttacggtatc gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt     1440

cttctgagat acattgatga gtttggacaa accacaacta gaatgcagtg aaaaaaatgc     1500

tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa     1560

caagttaaca acaacaattg cattcatttt atgtttcggg ttcaggggga ggtgtgggag     1620

gttttttaaa gcaagtaaaa cctctacaaa tgtggtatgg ctgattatga tc             1672


<210>  19
<211>  200
<212>  DNA
<213>  Artificial sequence

<220>
<223>  transcription termination sequence from Human beta-Globin

<400>  19
gcatagtgtt accatcaacc accttaactt catttttctt attcaatacc taggtaggta       60

gatgctagat tctggaaata aaatatgagt ctcaagtggt ccttgtcctc tctcccagtc      120

aaattctgaa tctagttggc aagattctga aatcaaggca tataatcagt aataagtgat      180

gatagaaggg tatatagaag                                                  200


<210>  20
<211>  130
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR, forward

<400>  20
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  21
<211>  1188
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human EF1-alpha Promoter, Exon1, Intron 1, and Exon2 (partial)

<400>  21
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacgcccctg gctgcagtac gtgattcttg atcccgagct tcgggttgga      360

agtgggtggg agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt      420

gaggcctggc ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt      480

ctcgctgctt tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt      540

tttttctggc aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt      600

tttggggccg cgggcggcga cggggcccgt gcgtcccagc gctcatgttc ggcgaggcgg      660

ggcctgcgag cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct      720

ctggtgcctg gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg      780

tcggcaccag ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca      840

aaatggagga cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg      900

gcctttccgt cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg      960

cacctcgatt agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt     1020

tatgcgatgg agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac     1080

ttgatgtaat tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag     1140

cctcagacag tggttcaaag tttttttctt ccatttcagg tgtcgtga                  1188


<210>  22
<211>  1434
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mCHerry-E2A-Human HPRT fusion gene

<400>  22
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaaggg aagcggacag      720

tgtactaatt atgctctctt gaaattggct ggagatgttg agagcaaccc tggacctatg      780

gcgacccgca gccctggcgt cgtgattagt gatgatgaac ccggttatga ccttgattta      840

ttttgcatac ctaatcatta tgctgaggat ttggaaaggg tgtttattcc tcatggacta      900

attatggaca ggactgaacg tcttgctcga gatgtgatga aggagatggg aggccatcac      960

attgtagccc tctgtgtgct caaggggggc tataaattct ttgctgacct gctggattac     1020

atcaaagcac tgaatagaaa tagtgataga tccattccta tgactgtaga ttttatcaga     1080

ctgaagagct attgtaatga ccagtcaaca ggggacataa aagtaattgg tggagatgat     1140

ctctcaactt taactggaaa gaatgtcttg attgtggaag atataattga cactggcaaa     1200

acaatgcaga ctttgctttc cttggtcagg cagtataatc caaagatggt caaggtcgct     1260

agcttgctgg tgaaaaggac cccacgaagt gttggatata agccagactt tgttggattt     1320

gaaattccag acaagtttgt tgtaggatat gcccttgact ataatgaata cttcagggat     1380

ttgaatcatg tttgtgtcat tagtgaaact ggaaaagcaa aatacaaagc ctaa           1434


<210>  23
<211>  272
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Poly-adenylation signal from Herpes Simplex Virus Thymidine 
       Kinase Gene

<400>  23
gggggaggct aactgaaaca cggaaggaga caataccgga aggaacccgc gctatgacgg       60

caataaaaag acagaataaa acgcacggtg ttgggtcgtt tgttcataaa cgcggggttc      120

ggtcccaggg ctggcactct gtcgataccc caccgagacc ccattggggc caatacgccc      180

gcgtttcttc cttttcccca ccccaccccc caagttcggg tgaaggccca gggctcgcag      240

ccaacgtcgg ggcggcaggc cctgccatag cc                                    272


<210>  24
<211>  1031
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human anti-repressor element 40 (AY190756.1)

<400>  24
gatcaagaaa gcactccggg ctccagaagg agccttccag gccagctttg agcataagct       60

gctgatgagc agtgagtgtc ttgagtagtg ttcagggcag catgttacca ttcatgcttg      120

acttctagcc agtgtgacga gaggctggag tcaggtctct agagagttga gcagctccag      180

ccttagatct cccagtctta tgcggtgtgc ccattcgctt tgtgtctgca gtcccctggc      240

cacacccagt aacagttctg ggatctatgg gagtagcttc cttagtgagc tttcccttca      300

aatactttgc aaccaggtag agaagtttgg agtgaaggtt ttgttcttcg tttcttcaca      360

atatggatat gcatcttctt ttgaaaatgt taaagtaaat tacctctctt ttcagatact      420

gtcttcatgc gaacttggta tcctgtttcc atcccagcct tctataaccc agtaacatct      480

tttttgaaac cagtgggtga gaaagacacc tggtcaggaa cgcggaccac aggacaactc      540

aggctcaccc acggcatcag actaaaggca aacaaggact ctgtataaag taccggtggc      600

atgtgtatta gtggagatgc agcctgtgct ctgcagacag ggagtcacac agacactttt      660

ctataatttc ttaagtgctt tgaatgttca agtagaaagt ctaacattaa atttgattga      720

acaattgtat attcatggaa tattttggaa cggaatacca aaaaatggca atagtggttc      780

tttctggatg gaagacaaac ttttcttctt taaaataaat tttattttat atatttgagg      840

ttgaccacat gaccttaagg atacatatag acagtaaact ggttactaca gtgaagcaaa      900

ttaacatatc taccatcgta catagttaca tttttttgtg tgacaggaac agctaaaatc      960

tacgtattta acaaaactcc taaagacaat acatttttat taactatagc cctcatgatg     1020

tacattagat c                                                          1031


<210>  25
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mouse anti-repressor element 40

<400>  25
acttgaattt tcaagtataa agtctagtgc taaatttaat ttgaacaact gtatagtttt       60

tgctggttgg gggaaggaaa aaaaatggtg gcagtgtttt tttcagaatt agaagtgaaa      120

tgaaaacttg ttgtgtgtga ggatttctaa tgccatgtgg tggttgcata ctgagtgaag      180

ccggtgagca ttctgccatg tcaccccctc gtgctcagta atgtacttta cagaaatcct      240

aaactcaaaa gattgatata aaccatgctt cttgtgtata tccggtctct tctctgggta      300

gtctcactca gcctgcattt ctgccatccc ttgtcctctg gcccccgtcg ccca            354


<210>  26
<211>  222
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Herpes Virus Thymidine Kinase Gene Promoter

<400>  26
ttcagggagt ggcgcagctg cttcatcccc gtggcccgtt gctcgcgttt gctggcggtg       60

tccccggaag aaatatattt gcatgtcttt agttctatga tgacacaaac cccgcccagc      120

gtcttgtcat tggcgaaaac acgcagatgc agtcggggcg gcgcggtccc aggtccactt      180

cgcatattaa ggtgacgcgt gtggcctcga acacagagcg ac                         222


<210>  27
<211>  600
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Puromycin N-acetyl transferase coding region

<400>  27
atgaccgagt acaagcccac ggtgcgcctc gccacccgcg acgacgtccc ccgggccgta       60

cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc gccacaccgt tgacccggac      120

cgccacatcg agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgac      180

atcggcaagg tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac cacgccggag      240

agcgtcgaag cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt      300

tcccggctgg ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag      360

cccgcgtggt tcctggccac cgtcggcgtc tcgcccgacc accagggcaa gggtctgggc      420

agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg      480

gagacctccg cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc      540

gacgtcgagg tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc cggtgcctga      600


<210>  28
<211>  224
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Polyadenylation Signal from Bovine Growth Hormone Gene

<400>  28
tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct       60

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct      120

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg      180

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atgg                       224


<210>  29
<211>  490
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Epstein Barr Virus OriP Replication Element

<400>  29
cccccttatt aaccctaaac gggtagcata tgcttcccgg gtagtagtat atactatcca       60

gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta tcgaattagg      120

gttagtaaaa gggtcctaag gaacagcgat ctggatagca tatgctatcc taatctatat      180

ctgggtagca tatgctatcc taatctatat ctgggtagca taggctatcc taatctatat      240

ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc taatttatat      300

ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc taatctatat      360

ctgggtagta tatgctatcc taatctgtat ccgggtagca tatgctatcc tcatgcatat      420

acagtcagca tatgataccc agtagtagag tgggagtgct atcctttgca tatgccgcca      480

cctcccaagg                                                             490


<210>  30
<211>  1815
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pUC57 vector sequences encoding plasmid replication origin and 
       ampicillin resistance gene

<400>  30
cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa       60

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt      120

gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg      180

cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag      240

atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg      300

agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg      360

gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt      420

ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga      480

cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac      540

ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc      600

atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc      660

gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac      720

tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag      780

gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg      840

gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta      900

tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg      960

ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata     1020

tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt     1080

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc     1140

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct     1200

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa     1260

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag     1320

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc     1380

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg     1440

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca     1500

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat     1560

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     1620

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     1680

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     1740

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc     1800

cttttgctca catgt                                                      1815


<210>  31
<211>  7671
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P321 Plasmid for Generating Recombinant Adenovirus expressing 
       SR21 Recombinase

<400>  31
ttaattaacc gcaattctca tgtttgacag cttatcatca tcaataatat accttatttt       60

ggattgaagc caatatgata atgagggggt ggagtttgtg acgtggcgcg gggcgtggga      120

acggggcggg tgacgtagta gtgtggcgga agtgtgatgt tgcaagtgtg gcggaacaca      180

tgtaagcgac ggatgtggca aaagtgacgt ttttggtgtg cgccggtgta cacaggaagt      240

gacaattttc gcgcggtttt aggcggatgt tgtagtaaat ttgggcgtaa ccgagtaaga      300

tttggccatt ttcgcgggaa aactgaataa gaggaagtga aatctgaata attttgtgtt      360

actcatagcg cgtaatattt gtctagggcc gcggggactt tgaccgttta cgtggagact      420

cgcccaggtg tttttctcag gtgttttccg cgttccgggt caaagttggc gttttattat      480

tatagtcagt acgtaccagt gcactggcct aggctctctt aaggtagctc gaggagcttg      540

gcccattgca tacgttgtat ccatatcata atatgtacat ttatattggc tcatgtccaa      600

cattaccgcc atgttgacat tgattattga ctagttatta atagtaatca attacggggt      660

cattagttca tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc      720

ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag      780

taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc      840

acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg      900

gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc      960

agtacatcta cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca     1020

atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca     1080

atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg     1140

ccccattgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc     1200

gtttagtgaa ccgtcggcgc gccgccacca tggaattaaa acacattgtc aattcctata     1260

atgtgactaa aattattggc tatttgagac gttccagaca agatgttgaa agagagaagc     1320

gtactggtga agatactttg acagaacaaa aagaacttat gaataaaata ttgactggga     1380

ttgaaatacc gtacgaaaca agaactgaga tcggttctgg tgaaagcatt gaaggaagac     1440

cagtgtttaa aagttgctta gctgatctga ggtctggaaa atttcaagca attgctgtaa     1500

aagaaataac tcgtcttagt cgtggtagtt acagtgatgc tggtgaaatc gtcaatcttc     1560

taaatgaaaa aaggattatc ataattacac catataaaat atatgatcca agaaatcctg     1620

ttgatgctcg tcaaattaga tttgagctat ttatggctag agaagaattt gaaatgacaa     1680

gagaaagaat gaatggtgcc aagtttactt atgctgcaca aggaaaatgg atttctggtt     1740

tagcaccatt tggctataaa ttaaataagc gtacatctcg cctcgaacca tcggatgaag     1800

acaaagttgt ggtaaagttg atatttgaca ttttcttaaa tggccttgat ggtaaagatt     1860

taagttatac agctattgca actcatcttt ctaaacttca attcactacc ccaaggggag     1920

gaaaaagatg gagtaaggac actgttagaa aaattcttca aaatgaagcc tatatgggaa     1980

gggttaggta taaagcaaga gaaaccacaa aagatggaaa aaaagtcttc cgacctgaaa     2040

gtgaacatat tgttgtagat gatgcccacg aaccaataat aaataaagag gactttgaag     2100

ctgttcaaga aaagattaaa aataaagtgc ctctgcttcc agtcgtaaca tcttatgaac     2160

ctaatgaatt agcgggaata tgtgtatgct ctgtctgtgg aaaatcactt caaaaatttg     2220

aatccgaata caataggaaa aacaaagatg ggacttccag ctattttcac gtgaagttat     2280

tgatttgcaa aatcaacaag tgcacatcag tgagatatga gtatgttgaa gaagcaattt     2340

tggagtatct tgagcagttg attgctttag aaaataataa actaaaggct ataattgaaa     2400

aatctatgga agcagcagaa actaacaatt cagaaaagac aagtgagcaa atgctagtac     2460

aagcaaacca aaaacagaaa gaactcgaaa acaaattgac atttattttt gaaaaatttg     2520

aatctggaat ttatacagat gaaatgtttt tgcaaaggaa agcagctatt gaaaaagaag     2580

tagctgacat taaaaaattg aaacaagaac ttagcatgac atttgaagtt aaagagaaag     2640

atgttaatga atttagggtt aacatatcag atgtagttaa attttataaa gaatctaaaa     2700

gtagaggatt aaaaaatgaa aagttgagat ccatttttga ctttatagta ttagaaatga     2760

cagagaaaag acgaggcccc atccctgcta agttcaatat ttatccggtt ttgcgaatcc     2820

cgagtgtagt taattagtct agagatacat tgatgagttt ggacaaacca caactagaat     2880

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     2940

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     3000

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggctga     3060

ttatgatcgc ggccgcctag atctgtactg aaatgtgtgg gcgtggctta agggtgggaa     3120

agaatatata aggtgggggt cttatgtagt tttgtatctg ttttgcagca gccgccgccg     3180

ccatgagcac caactcgttt gatggaagca ttgtgagctc atatttgaca acgcgcatgc     3240

ccccatgggc cggggtgcgt cagaatgtga tgggctccag cattgatggt cgccccgtcc     3300

tgcccgcaaa ctctactacc ttgacctacg agaccgtgtc tggaacgccg ttggagactg     3360

cagcctccgc cgccgcttca gccgctgcag ccaccgcccg cgggattgtg actgactttg     3420

ctttcctgag cccgcttgca agcagtgcag cttcccgttc atccgcccgc gatgacaagt     3480

tgacggctct tttggcacaa ttggattctt tgacccggga acttaatgtc gtttctcagc     3540

agctgttgga tctgcgccag caggtttctg ccctgaaggc ttcctcccct cccaatgcgg     3600

tttaaaacat aaataaaaaa ccagactctg tttggatttg gatcaagcaa gtgtcttgct     3660

gtctttattt aggggttttg cgcgcgcggt aggcccggga ccagcggtct cggtcgttga     3720

gggtcctgtg tattttttcc aggacgtggt aaaggtgact ctggatgttc agatacatgg     3780

gcataagccc gtctctgggg tggaggtagc accactgcag agcttcatgc tgcggggtgg     3840

tgttgtagat gatccagtcg tagcaggagc gctgggcgtg gtgcctaaaa atgtctttca     3900

gtagcaagct gattgccagg ggcaggccct tggtgtaagt gtttacaaag cggttaagct     3960

gggatgggtg catacgtggg gatatgagat gcatcttgga ctgtattttt aggttggcta     4020

tgttcccagc catatccctc cggggattca tgttgtgcag aaccaccagc acagtgtatc     4080

cggtgcactt gggaaatttg tcatgtagct tagaaggaaa tgcgtggaag aacttggaga     4140

cgcccttgtg acctccaaga ttttccatgc attcgtccat aatgatggca atgggcccac     4200

gggcggcggc ctgggcgaag atatttctgg gatcactaac gtcatagttg tgttccagga     4260

tgagatcgtc ataggccatt tttacaaagc gcgggcggag ggtgccagac tgcggtataa     4320

tggttccatc cggcccaggg gcgtagttac cctcacagat ttgcatttcc cacgctttga     4380

gttcagatgg ggggatcatg tctacctgcg gggcgatgaa gaaaacggtt tccggggtag     4440

gggagatcag ctgggaagaa agcaggttcc tgagcagctg cgacttaccg cagccggtgg     4500

gcccgtaaat cacacctatt accggctgca actggtagtt aagagagctg cagctgccgt     4560

catccctgag caggggggcc acttcgttaa gcatgtccct gactcgcatg ttttccctga     4620

ccaaatccgc cagaaggcgc tcgccgccca gcgatagcag ttcttgcaag gaagcaaagt     4680

ttttcaacgg tttgagaccg tccgccgtag gcatgctttt gagcgtttga ccaagcagtt     4740

ccaggcggtc ccacagctcg gtcacctgct ctacggcatc tcgatccagc atatctcctc     4800

gtttcgcggg ttggggcggc tttcgctgta cggcagtagt cggtgctcgt ccagacgggc     4860

cagggtcatg tctttccacg ggcgcagggt cctcgtcagc gtagtctggg tcacggtgaa     4920

ggggtgcgct ccgggctgcg cgctggccag ggtgcgcttg aggctggtcc tgctggtgct     4980

gaagcgctgc cggtcttcgc cctgcgcgtc ggccaggtag catttgacca tggtgtcata     5040

gtccagcccc tccgcggcgt ggcccttggc gcgcagcttg cccttggagg aggcgccgca     5100

cgaggggcag tgcagacttt tgagggcgta gagcttgggc gcgagaaata ccgattccgg     5160

ggagtaggca tccgcgccgc aggccccgca gacggtctcg cattccacga gccaggtgag     5220

ctctggccgt tcggggtcaa aaaccaggtt tcccccatgc tttttgatgc gtttcttacc     5280

tctggtttcc atgagccggt gtccacgctc ggtgacgaaa aggctgtccg tgtccccgta     5340

tacagacttg agaggcctgt cctcgagcgg tgttccgcgg tcctcctcgt atagaaactc     5400

ggaccactct gagacaaagg ctcgcgtcca ggccagcacg aaggaggcta agtgggaggg     5460

gtagcggtcg ttgtccacta gggggtccac tcgctccagg gtgtgaagac acatgtcgcc     5520

ctcttcggca tcaaggaagg tgattggttt gtaggtgtag gccacgtgac cgggtgttcc     5580

tgaagggggg ctataaaagg gggtgggggc gcgttcgtcc tcactctctt ccgcatcgct     5640

gtctgcgagg gccagctgtt ggggtgagtc gacgcgaggc tggatggcct tccccattat     5700

gattcttctc gcttccggcg gcatcgggat gcccgcgttg caggccatgc tgtccaggca     5760

ggtagatgac gaccatcagg gacagcttca aggccagcaa aaggccagga accgtaaaaa     5820

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     5880

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     5940

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     6000

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     6060

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     6120

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     6180

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     6240

gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc     6300

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     6360

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     6420

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     6480

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     6540

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     6600

ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt     6660

tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag     6720

tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag caataaacca     6780

gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc     6840

tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt     6900

tgttgccatt gctgcaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag     6960

ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt     7020

tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat     7080

ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt     7140

gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc     7200

ttgcccggcg tcaacacggg ataataccgc gccacatagc agaactttaa aagtgctcat     7260

cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag     7320

ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt     7380

ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg     7440

gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta     7500

ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc     7560

gcgcacattt ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt     7620

aacctataaa aataggcgta tcacgaggcc ctttcgtctt caagaattgt t              7671


<210>  32
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer P349F3

<400>  32
cgtaaacggt tggtggcgca                                                   20


<210>  33
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer P349R9

<400>  33
gtagaagggc acagtgtggg ctat                                              24


<210>  34
<211>  606
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence containing SEQ ID NO:14 Upstream half of beta-Actin 
       Intron and SEQ ID NO:15 Downstream half of beta-Actin intron


<220>
<221>  misc_feature
<222>  (144)..(178)
<223>  SEQ ID NO:14 Upstream half of beta-Actin Intron

<220>
<221>  misc_feature
<222>  (237)..(312)
<223>  SEQ ID NO:15 Downstream half of beta-Actin Intron

<400>  34
cgcagacgca ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca       60

gatcaaaaac ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta      120

cctcggagaa gcagtggatc caggtgggtg tctttcctgc ctgagctgac ctgggcagac      180

gcgtaattaa gtatcatgat aaactgacaa agcggtttct ccaacgaatt atcgattcgg      240

ctgtggggtc ctgtggtgtg tggggagctg tcacatccag ggtcctcact gcctgtcccc      300

ttccctcctc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg      360

tcccaaatta aggctgcctt ggacaatgcg ggaaagatta tgagcctgac taaaaccgcc      420

cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg gatttataaa      480

attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct gggatgggcc      540

acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac taccgggaag      600

accaac                                                                 606


<210>  35
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AttL Recombined sequence

<400>  35
aattaagtat catgataaac tgacaaagcg gtttctccaa cgaat                       45


<210>  36
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mCherry Primer 1

<400>  36
ctgttccacg atggtgtagt c                                                 21


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mCherry Primer 2

<400>  37
tgaggtcaag accacctaca                                                   20


<210>  38
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mCherry Probe, FAM at 5' end, ZEN between bases 9 and 10, 3IABkFQ
       at 3' end

<400>  38
ttggacatca cctcccacaa cgag                                              24


<210>  39
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Adenovirus Exon 2 (Ad5E2) Primer 1

<400>  39
gggtgatgca gtagaaggta ag                                                22


<210>  40
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Adenovirus Exon 2 (Ad5E2) Primer 2

<400>  40
atgaagttcg gcggagatg                                                    19


<210>  41
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Adenovirus Exon 2 (Ad5E2) Probe, HEX at 5' end, Zen between bases
       9 and 10, 3IABkFQ at 3' end

<400>  41
tcttgttccc agcggtccca tc                                                22


<210>  42
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P5 (P5 Promoter region of AAV) Primer 1

<400>  42
gtggtcacgc tgggtattta                                                   20


<210>  43
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P5 (P5 Promoter region of AAV) Primer 2

<400>  43
gggaccttaa tcacaatctc gt                                                22


<210>  44
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P5 (P5 Promoter region of AAV) Probe, FAM at 5' end, ZEN between 
       bases 9 and 10, 31ABkFQ at 3' end

<400>  44
tttgaagcgg gaggtttgaa cgc                                               23


<210>  45
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV REP Gene Primer 1

<400>  45
gtccgtgagt gaagcagata tt                                                22


<210>  46
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV REP Gene Primer 2

<400>  46
ttcgatcaac tacgcagaca g                                                 21


<210>  47
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV REP Gene Probe, FAM at 5' end, ZEN between bases 9 and 10, 
       3IABkFQ at 3' end

<400>  47
tctgatgctg tttccctgca gaca                                              24


<210>  48
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV9 CAP Gene Primer 1

<400>  48
ccgggtccaa ggtatttgta a                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV9 CAP Gene Primer 2

<400>  49
ctcaacccaa ggcaaatcaa c                                                 21


<210>  50
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AAV9 CAP Gene Probe, FAM at 5' end, ZEN between bases 9 and 10, 
       3IABkFQ at 3' end

<400>  50
acatcaagac aacgctcgag gtct                                              24


<210>  51
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Beta lactamase (Ampicillin resistance) gene Primer 1

<400>  51
ccagaaacgc tggtgaaagt a                                                 21


<210>  52
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Beta lactamase (Ampicillin resistance) gene Primer 2

<400>  52
ctcaaggatc ttaccgctgt tg                                                22


<210>  53
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Beta lactamase (Ampicillin resistance) gene Probe, FAM at 5' end,
       ZEN between bases 9 and 10, 3IABkFQ at 3' end

<400>  53
tgcacgagtg ggttacatcg aact                                              24


<210>  54
<211>  14
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bacillus safensis strain CCMA-560

<400>  54
actgacaaag cggt                                                         14


<210>  55
<211>  863
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5' portion of the AAV2 rep gene upstream of the stop cassette in 
       the exemplified construct

<400>  55
ggtcctgtat tagaggtcac gtgagtgttt tgcgacattt tgcgacacca tgtggtcacg       60

ctgggtattt aagcccgagt gagcacgcag ggtctccatt ttgaagcggg aggtttgaac      120

gcgcagccgc catgccgggg ttttacgaga ttgtgattaa ggtccccagc gaccttgacg      180

agcatctgcc cggcatttct gacagctttg tgaactgggt ggccgagaag gaatgggagt      240

tgccgccaga ttctgacatg gatctgaatc tgattgagca ggcacccctg accgtggccg      300

agaagctgca gcgcgacttt ctgacggaat ggcgccgtgt gagtaaggcc ccggaggccc      360

ttttctttgt gcaatttgag aagggagaga gctacttcca catgcacgtg ctcgtggaaa      420

ccaccggggt gaaatccatg gttttgggac gtttcctgag tcagattcgc gaaaaactga      480

ttcagagaat ttaccgcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga      540

ccagaaatgg cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact      600

tgctccccaa aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa      660

gcgcctgttt gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt      720

cgcagacgca ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca      780

gatcaaaaac ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta      840

cctcggagaa gcagtggatc cag                                              863


<210>  56
<211>  1150
<212>  DNA
<213>  Artificial sequence

<220>
<223>  3' portion of the AAV2 rep gene downstream of the stop cassette 
       in the exemplified construct

<400>  56
gaggaccagg cctcatacat ctccttcaat gcggcctcca actcgcggtc ccaaattaag       60

gctgccttgg acaatgcggg aaagattatg agcctgacta aaaccgcccc cgactacctg      120

gtgggccagc agcccgtgga ggacatttcc agcaatcgga tttataaaat tttggaacta      180

aacgggtacg atccccaata tgcggcttcc gtctttctgg gatgggccac gaaaaagttc      240

ggcaagagga acaccatctg gctgtttggg cctgcaacta ccgggaagac caacatcgcg      300

gaggccatag cccacactgt gcccttctac gggtgcgtaa actggaccaa tgagaacttt      360

cccttcaacg actgtgtcga caagatggtg atctggtggg aggaggggaa gatgaccgcc      420

aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt ggaccagaaa      480

tgcaagtcct cggcccagat agacccgact cccgtgatcg tcacctccaa caccaacatg      540

tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt gcaagaccgg      600

atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt caccaagcag      660

gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga gcatgagttc      720

tacgtcaaaa agggtggagc caagaaaaga cccgccccca gtgacgcaga tataagtgag      780

cccaaacggg tgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga agcttcgatc      840

aactacgcag acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa tctgatgctg      900

tttccctgca gacaatgcga gagaatgaat cagaattcaa atatctgctt cactcacgga      960

cagaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc tgtcgtcaaa     1020

aaggcgtatc agaaactgtg ctacattcat catatcatgg gaaaggtgcc agacgcttgc     1080

actgcctgcg atctggtcaa tgtggatttg gatgactgca tctttgaaca ataaatgatt     1140

taaatcaggt                                                            1150


<210>  57
<211>  2399
<212>  DNA
<213>  Artificial sequence

<220>
<223>  the AAV9 cap gene included in the exemplified construct, 
       including the polyadenylation signal of AAV2 having nucleotide 
       numbers 4411 to 4466 of the seq of GenBank NC_001401.2, and an AAV2
       rep P5 promoter having nucleotide 190 to to 313 of the seq of 
       

<400>  57
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga agggattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta attgcttgtt     2220

aatcaataaa ccgtttaatt cgtttcagtt gaactttggt ctctgcggtt taaacggtcc     2280

tgtattagag gtcacgtgag tgttttgcga cattttgcga caccatgtgg tcacgctggg     2340

tatttaagcc cgagtgagca cgcagggtct ccattttgaa gcgggaggtt tgaacgcgc      2399


<210>  58
<211>  600
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CCMA-560 DNA sequence (query) from Fig. 2

<400>  58
tgactttata gtattagaaa tgacagagaa aagacgaggc cccatccctg ctaagttcaa       60

tatttatccg gttttgcgaa ttccgagtgt agttaattaa gtatcatgat aaactgacaa      120

agcggtttct ccaacgaatg ccatgggtgc aacaaaattg atttcagaaa aactattttt      180

ccaagcaaac gaaagtattc cgaatcaaaa aacgaggttt tgctctgtac gctttggcaa      240

tgtgcttgga tctagaggtt ccgttattcc gatcatgctc cagcagctat taaatgaaaa      300

acctttgacc gtgactgatc ctcatatgac acgttttttt atgtccattg aagaggctgt      360

ttccctcaca cttcaagcag caatcatgat gaaaggcggc gaaaccttca ttctcaagat      420

ggagtcctta cagcttgccg atctcctaaa agcgtttcat gaatatgccg ctcaaatcaa      480

tgctaaatct ccggatattc ttgtagtcgg aaaaagacct ggcgaaaagc ttcacgagga      540

gctcacattt ccgcacgaag cagatgcact gtttgaacat gaacaatttt atgccatttt      600


<210>  59
<211>  488
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleotide 464352 to 464839 of whole genome shotgun sequence of 
       Bacillus safensis strain Fairview contig56_1 (Sbjct) from Fig. 2

<400>  59
actgacaaag cggtttctcc aacgaatgcc atgggtgcaa caaaattgat ttcagaaaaa       60

ctatttttcc aagcaaacga aagtattcca aataaaaaaa ccaagttttg ctctgtacgc      120

tttggcaatg tgcttggatc tagaggttcc gtgattccga tcatgctcca gcagctatta      180

aatgaaaaac ctttgaccgt gactgatcct catatgacac gtttttttat gtccattgaa      240

gaggctgttt ccctcacact tcaagcagca atcatgatga aaggcggcga aaccttcatt      300

ctcaagatgg agtccttaca gcttgccgat ctcctaaaag cgtttcatga atatgccgct      360

caaatcaatg ctaaatctcc ggatattctt gtagtcggaa aaagacctgg cgaaaagctt      420

cacgaggagc tcacatttcc gcacgaagca gatgcactgt ttgaacatga acaattttat      480

gccatttt                                                               488


<210>  60
<211>  225
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SV40 polyadenylation signal

<400>  60
gatacattga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt       60

gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta      120

acaacaacaa ttgcattcat tttatgtttc gggttcaggg ggaggtgtgg gaggtttttt      180

aaagcaagta aaacctctac aaatgtggta tggctgatta tgatc                      225


<210>  61
<211>  4281
<212>  DNA
<213>  Artificial sequence

<220>
<223>  the modified rep gene, including 5'rep, intron 5', stop cassette,intron 3' and 3' rep

<400>  61
ggtcctgtat tagaggtcac gtgagtgttt tgcgacattt tgcgacacca tgtggtcacg       60

ctgggtattt aagcccgagt gagcacgcag ggtctccatt ttgaagcggg aggtttgaac      120

gcgcagccgc catgccgggg ttttacgaga ttgtgattaa ggtccccagc gaccttgacg      180

agcatctgcc cggcatttct gacagctttg tgaactgggt ggccgagaag gaatgggagt      240

tgccgccaga ttctgacatg gatctgaatc tgattgagca ggcacccctg accgtggccg      300

agaagctgca gcgcgacttt ctgacggaat ggcgccgtgt gagtaaggcc ccggaggccc      360

ttttctttgt gcaatttgag aagggagaga gctacttcca catgcacgtg ctcgtggaaa      420

ccaccggggt gaaatccatg gttttgggac gtttcctgag tcagattcgc gaaaaactga      480

ttcagagaat ttaccgcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga      540

ccagaaatgg cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact      600

tgctccccaa aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa      660

gcgcctgttt gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt      720

cgcagacgca ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca      780

gatcaaaaac ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta      840

cctcggagaa gcagtggatc caggtgggtg tctttcctgc ctgagctgac ctgggcagac      900

gcgtaattaa gtatcatgat aaactgacaa agcggtatat caagatactt aatacatatg      960

gtcctgtaaa agtttaatgt gtaagaagta tttgttataa aagataaata ttcagaatct     1020

tctttttaat tcctgatttt atttctatag gactgaaaga cttgctcgag atgtcatgaa     1080

ggagatggga ggccatcaca ttctcacttc actgcagctc aacgtcccca attctaccgg     1140

gtaggggagg cgcttttccc aaggcagtct ggagcatgcg ctttagcagc cccgctgggc     1200

acttggcgct acacaagtgg cctctggcct cgcacacatt ccacatccac cggtaggcgc     1260

caaccggctc cgttctttgg tggccccttc gcgccacctt ctactcctcc cctagtcagg     1320

aagttccccc ccgccccgca gctcgcgtcg tgcaggacgt gacaaatgga agtagcacgt     1380

ctcactagtc tcgtgcagat ggacagcacc gctgagcaat ggaagcgggt aggcctttgg     1440

ggcagcggcc aatagcagct ttgctccttc gctttctggg ctcagaggct gggaaggggt     1500

gggtccgggg gcgggctcag gggcgggctc aggggcgggg cgggcgcccg aaggtcctcc     1560

ggaggcccgg cattctgcac gcttcaaaag cgcacgtctg ccgcgctgtt ctcctcttcc     1620

tcatctccgg gcctttcgac ctagcgggca gtgagcgcaa cgcaattaat gtgagttagc     1680

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa     1740

ttgtgagcgg ataacaattt cacacaggaa acagctgcca ccatgattga acaagatgga     1800

ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa     1860

cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt     1920

ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaagacga ggcagcgcgg     1980

ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa     2040

gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac     2100

cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt     2160

gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact     2220

cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg     2280

ccagccgaac tgttcgccag gctcaaggcg agcatgcccg acggcgagga tctcgtcgtg     2340

acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc     2400

atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt     2460

gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc     2520

gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgagat     2580

acattgatga gtttggacaa accacaacta gaatgcagtg aaaaaaatgc tttatttgtg     2640

aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa caagttaaca     2700

acaacaattg cattcatttt atgtttcggg ttcaggggga ggtgtgggag gttttttaaa     2760

gcaagtaaaa cctctacaaa tgtggtatgg ctgattatga tcgcatagtg ttaccatcaa     2820

ccaccttaac ttcatttttc ttattcaata cctaggtagg tagatgctag attctggaaa     2880

taaaatatga gtctcaagtg gtccttgtcc tctctcccag tcaaattctg aatctagttg     2940

gcaagattct gaaatcaagg catataatca gtaataagtg atgatagaag ggtatataga     3000

aggctagccg tcaacatctc cactgacaaa gcggtttctc caacgaatta tcgattcggc     3060

tgtggggtcc tgtggtgtgt ggggagctgt cacatccagg gtcctcactg cctgtcccct     3120

tccctcctca ggaggaccag gcctcataca tctccttcaa tgcggcctcc aactcgcggt     3180

cccaaattaa ggctgccttg gacaatgcgg gaaagattat gagcctgact aaaaccgccc     3240

ccgactacct ggtgggccag cagcccgtgg aggacatttc cagcaatcgg atttataaaa     3300

ttttggaact aaacgggtac gatccccaat atgcggcttc cgtctttctg ggatgggcca     3360

cgaaaaagtt cggcaagagg aacaccatct ggctgtttgg gcctgcaact accgggaaga     3420

ccaacatcgc ggaggccata gcccacactg tgcccttcta cgggtgcgta aactggacca     3480

atgagaactt tcccttcaac gactgtgtcg acaagatggt gatctggtgg gaggagggga     3540

agatgaccgc caaggtcgtg gagtcggcca aagccattct cggaggaagc aaggtgcgcg     3600

tggaccagaa atgcaagtcc tcggcccaga tagacccgac tcccgtgatc gtcacctcca     3660

acaccaacat gtgcgccgtg attgacggga actcaacgac cttcgaacac cagcagccgt     3720

tgcaagaccg gatgttcaaa tttgaactca cccgccgtct ggatcatgac tttgggaagg     3780

tcaccaagca ggaagtcaaa gactttttcc ggtgggcaaa ggatcacgtg gttgaggtgg     3840

agcatgagtt ctacgtcaaa aagggtggag ccaagaaaag acccgccccc agtgacgcag     3900

atataagtga gcccaaacgg gtgcgcgagt cagttgcgca gccatcgacg tcagacgcgg     3960

aagcttcgat caactacgca gacaggtacc aaaacaaatg ttctcgtcac gtgggcatga     4020

atctgatgct gtttccctgc agacaatgcg agagaatgaa tcagaattca aatatctgct     4080

tcactcacgg acagaaagac tgtttagagt gctttcccgt gtcagaatct caacccgttt     4140

ctgtcgtcaa aaaggcgtat cagaaactgt gctacattca tcatatcatg ggaaaggtgc     4200

cagacgcttg cactgcctgc gatctggtca atgtggattt ggatgactgc atctttgaac     4260

aataaatgat ttaaatcagg t                                               4281


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAVRT-F1

<400>  62
tgatgcgccg gtgatcagat                                                   20


<210>  63
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P349R9

<400>  63
gtagaagggc acagtgtggg ctat                                              24


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Splice Donor Site in 5'REP

<400>  64
cttcagccag gtacatggag                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated Splice Donor Site in 5'REP

<400>  65
cttcagccag atacatggag                                                   20


<210>  66
<211>  2000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Intron Spacer

<400>  66
ttacgtataa tacctccacg ttgagaccgt acgagcgcat aacggaagcg ttgttgagac       60

ccagtcgcct gtgataccgc cttggttaag gcccgtagcc tagcttaagg caacgaaaca      120

agacgactca ggagaatcat tatgaacagg gcgcgcggga ggtcgtggat atggccggta      180

ttttacttat gggaggatct tttggccgcg agacttccga gaaaccatca acagttcgat      240

ttcctccttt tatccttaac atagcacaga gttgccacat tgataggggg gcaggagatc      300

gtcacatgaa ccgacggtcg ggacatattc gatgccgtcc cctctcgaca accggattcc      360

tcgtttccaa tcgaatacca cgccccgggg atcgtgcgca cgataagcac aataagcgtc      420

actgcggggt caagctgtgg cttgcaggat gctaactcgt aacgacatta agacagcaga      480

gcaatgggcg acccaaaaag tttaagcctt tacctcgggg tggcaacata agtgtgccga      540

ctacgacagg aacccatgac tcctttgggg cgttctaatg ggcggggtct gctgttaacc      600

agctgatggg gcaagtggaa tagagcatgc cctacgcgct attaaggaat gcgtggctac      660

ttggctgtgc gtacttgctc aatgtatggc aacaaacaac ctaatctttg tcggcaacgc      720

gataatctcg ccacgttaat cggctacttg catggtagga ttcgatttta cgtatgtacc      780

acggattcta ttgcacgcta cagcatcaat gtgcccgatg actactagct gcccagaggg      840

gataaatcat gtgtaatttg gcgtgcattc gagttattgg cattaatttc tctatcaagt      900

gcagtcccta gcttcgagta agctatgcgt tcccccccgt acattttaat cccataggga      960

acggcacccg cacctattaa gagagcgcca tagctctaaa cgacccacgg tccaatgctt     1020

ataatttcta aaatttaagg tcgcattgcc ttgaccgtta gtccccctca cgtttgaggg     1080

cataatgttc ctgcgccctt tacaattagt ctaattctac ttaaaatcga cgcaggattt     1140

tttctgttgg ctccgctgcc atgggaagct gtctatggag ggctcggtta tccctggctt     1200

cttactatgt aatctacctt tacctttgct aattacgtgt acgtgaccag aaactacacg     1260

gaacgagtgg gacccataag ctgagcgatg gctagtgaga ccgcctgata tgactcacgg     1320

ggtaaccgtg caacgtgcat atatctaatg agtacggcac ctttccactt tgcttatatg     1380

agagtacagg ctacttagcc cgacgtgtac gccagatctg ggcacccgcc agcaggtccc     1440

actaggccgg cctgccaggc aaatgacctg agtgccgcga ctagcctcgg ccagacagct     1500

gactagcgat tcacaagtgc cgacttagta gttctttagc aatagaaata tagacatagt     1560

tccctcgaac tacagggaaa tacggcctgt ggttgcaaga taagaggctt ttaacactga     1620

cgtagtttac acactctggc cggaccatga atttcgtctg ctcccacgaa ccacattatc     1680

agtacttctt cttaagtgtt ttattaaatc gaataatcta caaatagttc taaaggagcg     1740

agttagagag aagttccacg ctccataact tcgagaccgt tagcgaagtt ttccagcaca     1800

cggctacggg accctgcact cagcttcatg gttttaggca cgagaaccgc atatagtgga     1860

gatttcgccg tggaagcaag tctgtcttag agagcctagg tgcttaggtt ttcggaactc     1920

tcctgattat attcaatttc catcccattc tggatcatca agtgcccgcg gatgacctac     1980

gggcaaattg ccccagataa                                                 2000


<210>  67
<211>  2072
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer 2

<400>  67
gtagtcccgc agtacgcggc taggcagatc ggccccttcc aaatccgtgt catcggaaga       60

ccatgttggt agtttcataa tggattttat tgattgctat gtaacctgaa cgacggtatt      120

aatgggcttc ttaacatgaa cgtgagtaac ggaaacatta cgcttttcgg tcgcgaatga      180

cggcgaactc tgggccttgt gggattatag atacgtcagt gttcctcggg aacggacaaa      240

gtaggaaata tcgacgacat ggatcatgcc aatatatcaa cgcgggaaga tgaccattga      300

tgcagtggga actggtgtcc cacaaatatc tagggcttgt gcagcggtca agggctgtgt      360

tccacctggg acgccagccc aattatacgc cagaaacgct tgattttact caggtagaaa      420

gggggaaaat acactacgcg accaactaat aattcctttc gcaaacttaa tggctgctaa      480

ttttcctcaa gaccggctta atgcctacta cacttaaggc gcggatggcg agatacgacg      540

cgggcacata ctaggcacgt catcggccag gcgttctaat ttaagttcac gcataaataa      600

gcgtctctcg agactgcaga tccccgtctt aaatttagta cacaacgctg tttaccaccg      660

gggcgttatg acttgcagac ccgtgcgtga atatcctgta tcattcatca ctgctgggac      720

taccccactt tacatatcta agggattcaa caaacttcgg gtggttaatg tcaagtgcgt      780

tattggcgta taacagggtg aatgcacatt gatggaatgc cttcaaccaa gctgtggcgt      840

cacgccagcc gaacacgttt tacccaaact tagccctttt gctgcgaccc tgctatctat      900

tggctatact ctatatgcaa tgggtgcaga tcggagaccg cgccattgtc accaccccaa      960

ggaggggaga ttcacgctcg ctcggattag cttcccggat catttatcaa aactggaaat     1020

actctaagct aagttcacct tcagatcctt gtcaagagtt gtcggcccga ttagtcgttg     1080

cgcacacgtg gcgtaattac agcacgcgag gtacattcga gtttatcctc tgggctccat     1140

tcaggcaata tgctgtcagc acgaagagtg tgacctggcg ctattgttgg cgacttgacg     1200

ccacggaata ccagtgtata tacatcctag gagaactgca agacttcggg cgtgtatcgt     1260

aggttatggt agtcactggg atttgcacct gcgcacaatc tgtttggtaa agtaaaagcg     1320

atacttcgcg actcccaata agtaacgata ctgcgcggca tcccttagcg ctctcatacc     1380

gagcgagata cagtctatat actcaacaga gcacgtttgg aacctgtgag gttcagcacc     1440

aatcattcat ctataaactc atcgagaaaa gtatggaggc cacgtgggct tcttcggttc     1500

agctaagcag actcatgagg gtgtggtctc ggctttggag gcagatattg tccggaattg     1560

taattgcgac tgcgcggcag tatagagtgt ctctatcatt gtaggactca cgcacccatc     1620

ggacaaccac gtgatggccc cttagttata tcgagggata ggggctatgc tcaagttagt     1680

cttaatttcg cgtgcttgca aggcttatcg ccggtccctc ctaccgtacc cggcctttca     1740

gggccatgat ctttgcctgc ttccctgttt atctacacca atattgggag acttgtatga     1800

cgagcgagcc actaaagagg acgattgtca acagggtgct ttatcacata atagcctgtt     1860

tctccaacag tgcttcaatt acctagcatc acagaatgcg ataagcccac cacgtgtttc     1920

ccaatggcgg ctattcatta atcgggacga cacccctatt cgtggagaga gcatcctatt     1980

gagtccgagc tgttagcgca tgattacggt gggccagaca gattcgacgg aatgccgcta     2040

ctacgctggc gcgtaatcag tcggaaccag aa                                   2072


<210>  68
<211>  2091
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer 3

<400>  68
tgtacacaat gatacgatcc cgtttctgcg acgtactcgg gtgtagctgg gaccctgtcg       60

catttaatcg ccggtcaata ggtacaccgt gctgatcttg gatactcctg atcgcgatgt      120

aacccgagcg gcgctactaa tgggcgtcct aacacgagcg cgaataacca cttgcgctag      180

gcaggattta cgatggtcat ctggaacgga cgggtacacc atgccaaaat ttgctcctag      240

ttcacaaggt caaacggtga cccggaggcc agtccactcc ttgtcctcgt ccttacgtta      300

ccgtaacctc tgacctggag cctaaggctg ctccggcatt ttaaaaacca cacaaataag      360

gcttcacact attcctatta tcttgtgtcc tacctaagag gtagtggagc gagtaggtag      420

acacaggcac tcaccaccga tgttccgccc atgggccatg gttaaggtcc gaatgaaacc      480

cgtatgcaag ttaccggcct tatattaata aggttggtat acatcctaaa agctctctcg      540

gacgtgacca aatacaggca tccacggagc actactgaat gggcacgtgg accggcgagt      600

gagaaatcga gcagcattaa gtcattctta gtaagccgag atgggtctgc gttatgtacg      660

tctagtgggg aaacaagttg gtggacaaac gttacgccta aggagctaat atttcggtca      720

ggttgcgctg ggtcaaatca accggtcctg gtaacggagc gatggttagg tgtattacac      780

tagcgatggg ccgtgccgga tggtacgcca cgttctccga gccagtgaaa ttggatgaga      840

actcgtaaat ctctcgttgc aaacagcttc ctcaatatat gacctggcca ctgatgagag      900

ggtaacactt aattcctaga atgtctgacg acatcaccct taagcagaca cactgcgatg      960

tgtggacgct agggtgtctc tttccacgtt tgacttagcc catgatgtct tgactaagat     1020

ggcagggtat ttccccttat tcgtgtatgt accactatta ccgtcgattg accgtcgccg     1080

cttatacgtc gtgccctgtg ccttggcaat tttgtccctg gataacccgc cttgcttcta     1140

tcgaggtcct tgaataagtt aatgcaactt gtggaggaac atagggaatg tggcgtgctg     1200

cttagatatg gagtgcaaga agtcctctgg gttgtagttt cactgttacg tcctagccag     1260

tgaagcactg gcatgcagct ttatctgagg attccactca ctgcttacaa gaatttgcca     1320

agctggtgcc gatatgaccc caacgctatc cagagtttaa gttgtcatct ctctccatca     1380

taattgccac agtgtgttgt gtctacgaat agctattaaa ataccagccc ctgagaacga     1440

tgcccgacac atagggcagt gcaggcagca taacgtgcag atcaacataa tttccactaa     1500

gtgttgatat agtttactgg ctgagagccg ccatattgga acgacgacga gagcgcgtat     1560

cctgcccaac cagaaatacg tgtccaatcc atataactga ccaaagctgc ggacagtttc     1620

ctctccacct acaacgggat tagcgcactt gcttgtagtg aggcaggtat aacccacggc     1680

acgtaacacc tttagacgtt cggttccgca atcgcacaat gtactactat tagagaacta     1740

tagcaaggaa cttatagcgt atcgaaagtt catccctgcg gcccatagcc gtaaccaccg     1800

tggggttatt ttaaacttta agttgtaccc tcaggcaagc gaagaccggt actttaccta     1860

catggggccg ctttccgagc cacgccgcac cccaacatat tcctacgcgc tgtaataatg     1920

aacataagag aaaatggagt tgggtgacag cacatatcga ctacctagcg actaccgcaa     1980

cacaaagtag atcccgccgg tatcctcctt tcatgcagga cgggttaccc aggaatgcgt     2040

ttgtttgact ggtgcccgct gaggcgctga atatctcgcg atagcgtgta c              2091


<210>  69
<211>  2794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mCherry-IRES-SEAP coding sequences

<400>  69
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaagta agtcgactac      720

tggccgaagc cgcttggaat aaggccggtg tgcgtttgtc tatatgtgat tttccaccat      780

attgccgtct tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat      840

tcctaggggt ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga      900

agcagttcct ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca      960

gcggaacccc ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac     1020

acctgcaaag gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt     1080

caaatggctc tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca     1140

ttgtatggga tctgatctgg ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt     1200

aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgatcg     1260

tacggccacc atgtggggag cctgcttgct gctgctgggc ctcagcctac aggtgtgccc     1320

gagcgtcatc ccagtggagg aggagaatcc agccttctgg aaccgaaagg cagccgaggc     1380

cctggatgct gccaagaagc tgaagcccat tcagacatca gctaagaacc tcgttatcct     1440

catgggagat gggatggggg tgtctacagt aaccgctacc cggatcttaa aggggcagca     1500

gcaaggccat ctgggacctg agacacagtt agctatggat cgctttccac acatggctct     1560

gtccaagaca tacaacacag acaagcagat cccggacagc gcaggcacag gtacagcctt     1620

tctctgcggg gtcaaaacca acatgaaggt cattggcttg agtgcagctg cacgcttcaa     1680

ccagtgcaac acgacatggg gtaacgaggt cgtctcggtg atgcaccgtg ctaagaaagc     1740

aggaaagtct gtgggagtgg tgaccaccac gtcggtgcag catgcttctc cggccggcac     1800

ctacgcgcac actgtgaacc gtggttggta ctcggatgca caaatgcctg cctcagcgct     1860

acaggatggc tgcaaagaca tctctactca gctcatctcc aacatggaca ttgatgtgat     1920

cctcggtggt ggccgcaagt tcatgtttcc caaggggaca ccagaccagg aatatccaac     1980

tgacaccaag caggctggaa ccaggctgga tggacgcaac ctagttcaag agtggctggc     2040

aaagcaccag ggagcccggt atgtttggaa ccgctcagag ctgattcagg catccctgaa     2100

ccgatctgtg acacacctca tgggcctctt tgagcctaac gacatgaaat atgaaatcca     2160

ccgagaccct gctcaggacc cttccctggc cgagatgacg gaggtggctg tgcgcatgct     2220

cagcaggaac cccaaaggct tctatctctt tgtggaaggg ggtcgcatcg accatggcca     2280

ccatgaaact gtagcctatc gtgccctgac tgaggctgtc atgttcgact cggctgttga     2340

caaggcagac aagctcacca gtgagcagga cacgatgatc cttgtcactg ccgaccactc     2400

tcacgtcttc tcttttggtg gttacacaca gagaggggct tccatctttg gactggctcc     2460

cttcaaggct gaggatggca aatcctttac ctcgatacta tacggcaacg gtcctggtta     2520

caagctccat aatggcgccc gggctgatgt cactgaggaa gagagcagca accccacgta     2580

ccagcagcag gctgctgtac ccctgtcgtc agagacccac agcggggagg acgtggcaat     2640

attcgcgcgt ggcccacagg cgcagctggt gcacggagtt caggagcaga actacatcgc     2700

gcacgtcatg gccttcgcag cctgcctgga gccctacact gactgcggcc tggcatcccc     2760

tgctggccag agcagtgcag tgagcccggg ctga                                 2794


<210>  70
<211>  22126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P600

<400>  70
taactataac ggtcctaagg tagcgaagat atccgatcaa gaaagcactc cgggctccag       60

aaggagcctt ccaggccagc tttgagcata agctgctgat gagcagtgag tgtcttgagt      120

agtgttcagg gcagcatgtt accattcatg cttgacttct agccagtgtg acgagaggct      180

ggagtcaggt ctctagagag ttgagcagct ccagccttag atctcccagt cttatgcggt      240

gtgcccattc gctttgtgtc tgcagtcccc tggccacacc cagtaacagt tctgggatct      300

atgggagtag cttccttagt gagctttccc ttcaaatact ttgcaaccag gtagagaagt      360

ttggagtgaa ggttttgttc ttcgtttctt cacaatatgg atatgcatct tcttttgaaa      420

atgttaaagt aaattacctc tcttttcaga tactgtcttc atgcgaactt ggtatcctgt      480

ttccatccca gccttctata acccagtaac atcttttttg aaaccagtgg gtgagaaaga      540

cacctggtca ggaacgcgga ccacaggaca actcaggctc acccacggca tcagactaaa      600

ggcaaacaag gactctgtat aaagtaccgg tggcatgtgt attagtggag atgcagcctg      660

tgctctgcag acagggagtc acacagacac ttttctataa tttcttaagt gctttgaatg      720

ttcaagtaga aagtctaaca ttaaatttga ttgaacaatt gtatattcat ggaatatttt      780

ggaacggaat accaaaaaat ggcaatagtg gttctttctg gatggaagac aaacttttct      840

tctttaaaat aaattttatt ttatatattt gaggttgacc acatgacctt aaggatacat      900

atagacagta aactggttac tacagtgaag caaattaaca tatctaccat cgtacatagt      960

tacatttttt tgtgtgacag gaacagctaa aatctacgta tttaacaaaa ctcctaaaga     1020

caatacattt ttattaacta tagccctcat gatgtacatt agatcctctc ttaaggtagc     1080

ccgaataaaa atagaaaaac aacaaatgtt aattttctat ttttatttgg tgtcgtactc     1140

aatccataat cgtcacaagc gttatagttt aagtacaaca atgtcgtcac cttgttggtg     1200

taattaggtt tacgccaaca gggtgataac aggcgcgccg gtcctgtatt agaggtcacg     1260

tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta agcccgagtg     1320

agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc atgccggggt     1380

tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc ggcatttctg     1440

acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat tctgacatgg     1500

atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag cgcgactttc     1560

tgacggaatg gcgccgtgtg agtaaggccc cggaggccct tttctttgtg caatttgaga     1620

agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg aaatccatgg     1680

ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt taccgcggga     1740

tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc gccggaggcg     1800

ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa acccagcctg     1860

agctccagtg ggcgtggact aatatggaac agtatttaag cgcctgtttg aatctcacgg     1920

agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag gagcagaaca     1980

aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact tcagccagat     2040

acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag cagtggatcc     2100

aggtgggtgt ctttcctgcc tgagctgacc tgggcagacg cgtaattaag tatcatgata     2160

aactgacaaa gcggtatatc aagatactta atacatatgg tcctgtaaaa gtttaatgtg     2220

taagaagtat ttgttataaa agataaatat tcagaatctt ctttttaatt cctgatttta     2280

tttctatagg actgaaagac ttgctcgaga tgtcatgaag gagatgggag gccatcacat     2340

tctcacttca ctgcagctca acgtccccaa ttctaccggg taggggaggc gcttttccca     2400

aggcagtctg gagcatgcgc tttagcagcc ccgctgggca cttggcgcta cacaagtggc     2460

ctctggcctc gcacacattc cacatccacc ggtaggcgcc aaccggctcc gttctttggt     2520

ggccccttcg cgccaccttc tactcctccc ctagtcagga agttcccccc cgccccgcag     2580

ctcgcgtcgt gcaggacgtg acaaatggaa gtagcacgtc tcactagtct cgtgcagatg     2640

gacagcaccg ctgagcaatg gaagcgggta ggcctttggg gcagcggcca atagcagctt     2700

tgctccttcg ctttctgggc tcagaggctg ggaaggggtg ggtccggggg cgggctcagg     2760

ggcgggctca ggggcggggc gggcgcccga aggtcctccg gaggcccggc attctgcacg     2820

cttcaaaagc gcacgtctgc cgcgctgttc tcctcttcct catctccggg cctttcgacc     2880

tagcgggcag tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg     2940

ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc     3000

acacaggaaa cagctgccac catgattgaa caagatggat tgcacgcagg ttctccggcc     3060

gcttgggtgg agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat     3120

gccgccgtgt tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg     3180

tccggtgccc tgaatgaact gcaagacgag gcagcgcggc tatcgtggct ggccacgacg     3240

ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta     3300

ttgggcgaag tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta     3360

tccatcatgg ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc     3420

gaccaccaag cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc     3480

gatcaggatg atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg     3540

ctcaaggcga gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg     3600

ccgaatatca tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt     3660

gtggcggacc gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc     3720

ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc     3780

atcgccttct atcgccttct tgacgagttc ttctgagata cattgatgag tttggacaaa     3840

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     3900

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     3960

tgtttcgggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     4020

gtggtatggc tgattatgat cgcatagtgt taccatcaac caccttaact tcatttttct     4080

tattcaatac ctaggtaggt agatgctaga ttctggaaat aaaatatgag tctcaagtgg     4140

tccttgtcct ctctcccagt caaattctga atctagttgg caagattctg aaatcaaggc     4200

atataatcag taataagtga tgatagaagg gtatatagaa ggctagccgt caacatctcc     4260

actgacaaag cggtttctcc aacgaattat cgatttacgt ataatacctc cacgttgaga     4320

ccgtacgagc gcataacgga agcgttgttg agacccagtc gcctgtgata ccgccttggt     4380

taaggcccgt agcctagctt aaggcaacga aacaagacga ctcaggagaa tcattatgaa     4440

cagggcgcgc gggaggtcgt ggatatggcc ggtattttac ttatgggagg atcttttggc     4500

cgcgagactt ccgagaaacc atcaacagtt cgatttcctc cttttatcct taacatagca     4560

cagagttgcc acattgatag gggggcagga gatcgtcaca tgaaccgacg gtcgggacat     4620

attcgatgcc gtcccctctc gacaaccgga ttcctcgttt ccaatcgaat accacgcccc     4680

ggggatcgtg cgcacgataa gcacaataag cgtcactgcg gggtcaagct gtggcttgca     4740

ggatgctaac tcgtaacgac attaagacag cagagcaatg ggcgacccaa aaagtttaag     4800

cctttacctc ggggtggcaa cataagtgtg ccgactacga caggaaccca tgactccttt     4860

ggggcgttct aatgggcggg gtctgctgtt aaccagctga tggggcaagt ggaatagagc     4920

atgccctacg cgctattaag gaatgcgtgg ctacttggct gtgcgtactt gctcaatgta     4980

tggcaacaaa caacctaatc tttgtcggca acgcgataat ctcgccacgt taatcggcta     5040

cttgcatggt aggattcgat tttacgtatg taccacggat tctattgcac gctacagcat     5100

caatgtgccc gatgactact agctgcccag aggggataaa tcatgtgtaa tttggcgtgc     5160

attcgagtta ttggcattaa tttctctatc aagtgcagtc cctagcttcg agtaagctat     5220

gcgttccccc ccgtacattt taatcccata gggaacggca cccgcaccta ttaagagagc     5280

gccatagctc taaacgaccc acggtccaat gcttataatt tctaaaattt aaggtcgcat     5340

tgccttgacc gttagtcccc ctcacgtttg agggcataat gttcctgcgc cctttacaat     5400

tagtctaatt ctacttaaaa tcgacgcagg attttttctg ttggctccgc tgccatggga     5460

agctgtctat ggagggctcg gttatccctg gcttcttact atgtaatcta cctttacctt     5520

tgctaattac gtgtacgtga ccagaaacta cacggaacga gtgggaccca taagctgagc     5580

gatggctagt gagaccgcct gatatgactc acggggtaac cgtgcaacgt gcatatatct     5640

aatgagtacg gcacctttcc actttgctta tatgagagta caggctactt agcccgacgt     5700

gtacgccaga tctgggcacc cgccagcagg tcccactagg ccggcctgcc aggcaaatga     5760

cctgagtgcc gcgactagcc tcggccagac agctgactag cgattcacaa gtgccgactt     5820

agtagttctt tagcaataga aatatagaca tagttccctc gaactacagg gaaatacggc     5880

ctgtggttgc aagataagag gcttttaaca ctgacgtagt ttacacactc tggccggacc     5940

atgaatttcg tctgctccca cgaaccacat tatcagtact tcttcttaag tgttttatta     6000

aatcgaataa tctacaaata gttctaaagg agcgagttag agagaagttc cacgctccat     6060

aacttcgaga ccgttagcga agttttccag cacacggcta cgggaccctg cactcagctt     6120

catggtttta ggcacgagaa ccgcatatag tggagatttc gccgtggaag caagtctgtc     6180

ttagagagcc taggtgctta ggttttcgga actctcctga ttatattcaa tttccatccc     6240

attctggatc atcaagtgcc cgcggatgac ctacgggcaa attgccccag ataaattcgg     6300

ctgtggggtc ctgtggtgtg tggggagctg tcacatccag ggtcctcact gcctgtcccc     6360

ttccctcctc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg     6420

tcccaaatta aggctgcctt ggacaatgcg ggaaagatta tgagcctgac taaaaccgcc     6480

cccgactacc tggtgggcca gcagcccgtg gaggacattt ccagcaatcg gatttataaa     6540

attttggaac taaacgggta cgatccccaa tatgcggctt ccgtctttct gggatgggcc     6600

acgaaaaagt tcggcaagag gaacaccatc tggctgtttg ggcctgcaac taccgggaag     6660

accaacatcg cggaggccat agcccacact gtgcccttct acgggtgcgt aaactggacc     6720

aatgagaact ttcccttcaa cgactgtgtc gacaagatgg tgatctggtg ggaggagggg     6780

aagatgaccg ccaaggtcgt ggagtcggcc aaagccattc tcggaggaag caaggtgcgc     6840

gtggaccaga aatgcaagtc ctcggcccag atagacccga ctcccgtgat cgtcacctcc     6900

aacaccaaca tgtgcgccgt gattgacggg aactcaacga ccttcgaaca ccagcagccg     6960

ttgcaagacc ggatgttcaa atttgaactc acccgccgtc tggatcatga ctttgggaag     7020

gtcaccaagc aggaagtcaa agactttttc cggtgggcaa aggatcacgt ggttgaggtg     7080

gagcatgagt tctacgtcaa aaagggtgga gccaagaaaa gacccgcccc cagtgacgca     7140

gatataagtg agcccaaacg ggtgcgcgag tcagttgcgc agccatcgac gtcagacgcg     7200

gaagcttcga tcaactacgc agacaggtac caaaacaaat gttctcgtca cgtgggcatg     7260

aatctgatgc tgtttccctg cagacaatgc gagagaatga atcagaattc aaatatctgc     7320

ttcactcacg gacagaaaga ctgtttagag tgctttcccg tgtcagaatc tcaacccgtt     7380

tctgtcgtca aaaaggcgta tcagaaactg tgctacattc atcatatcat gggaaaggtg     7440

ccagacgctt gcactgcctg cgatctggtc aatgtggatt tggatgactg catctttgaa     7500

caataaatga tttaaatcag gtatggctgc cgatggttat cttccagatt ggctcgagga     7560

caaccttagt gaagggattc gcgagtggtg ggctttgaaa cctggagccc ctcaacccaa     7620

ggcaaatcaa caacatcaag acaacgctcg aggtcttgtg cttccgggtt acaaatacct     7680

tggacccggc aacggactcg acaaggggga gccggtcaac gaagcagacg cggcggccct     7740

cgagcacgac aaggcctacg accagcagct caaggccgga gacaacccgt acctcaagta     7800

caaccacgcc gacgccgagt tccaggagcg gctcaaagaa gatacgtctt ttgggggcaa     7860

cctcgggcga gcagtcttcc aggccaaaaa gaggcttctt gaacctcttg gtctggttga     7920

ggaagcggct aagacggctc ctggaaagaa gaggcctgta gagcagtctc ctcaggaacc     7980

ggactcctcc gtgggtattg gcaaatcggg tgcacagccc gctaaaaaga gactcaattt     8040

cggtcagact ggcgacacag agtcagtccc agaccctcaa ccaatcggag aacctcccgc     8100

agccccctca ggtgtgggat ctcttacaat ggcttcaggt ggtggcgcac cagtggcaga     8160

caataacgaa ggtgccgatg gagtgggtag ttcctcggga aattggcatt gcgattccca     8220

atggctgggg gacagagtca tcaccaccag cacccgaacc tgggccctgc ccacctacaa     8280

caatcacctc tacaagcaaa tctccaacag cacatctgga ggatcttcaa atgacaacgc     8340

ctacttcggc tacagcaccc cctgggggta ttttgacttc aacagattcc actgccactt     8400

ctcaccacgt gactggcagc gactcatcaa caacaactgg ggattccggc ctaagcgact     8460

caacttcaag ctcttcaaca ttcaggtcaa agaggttacg gacaacaatg gagtcaagac     8520

catcgccaat aaccttacca gcacggtcca ggtcttcacg gactcagact atcagctccc     8580

gtacgtgctc gggtcggctc acgagggctg cctcccgccg ttcccagcgg acgttttcat     8640

gattcctcag tacgggtatc tgacgcttaa tgatggaagc caggccgtgg gtcgttcgtc     8700

cttttactgc ctggaatatt tcccgtcgca aatgctaaga acgggtaaca acttccagtt     8760

cagctacgag tttgagaacg tacctttcca tagcagctac gctcacagcc aaagcctgga     8820

ccgactaatg aatccactca tcgaccaata cttgtactat ctctcaaaga ctattaacgg     8880

ttctggacag aatcaacaaa cgctaaaatt cagtgtggcc ggacccagca acatggctgt     8940

ccagggaaga aactacatac ctggacccag ctaccgacaa caacgtgtct caaccactgt     9000

gactcaaaac aacaacagcg aatttgcttg gcctggagct tcttcttggg ctctcaatgg     9060

acgtaatagc ttgatgaatc ctggacctgc tatggccagc cacaaagaag gagaggaccg     9120

tttctttcct ttgtctggat ctttaatttt tggcaaacaa ggaactggaa gagacaacgt     9180

ggatgcggac aaagtcatga taaccaacga agaagaaatt aaaactacta acccggtagc     9240

aacggagtcc tatggacaag tggccacaaa ccaccagagt gcccaagcac aggcgcagac     9300

cggctgggtt caaaaccaag gaatacttcc gggtatggtt tggcaggaca gagatgtgta     9360

cctgcaagga cccatttggg ccaaaattcc tcacacggac ggcaactttc acccttctcc     9420

gctgatggga gggtttggaa tgaagcaccc gcctcctcag atcctcatca aaaacacacc     9480

tgtacctgcg gatcctccaa cggccttcaa caaggacaag ctgaactctt tcatcaccca     9540

gtattctact ggccaagtca gcgtggagat cgagtgggag ctgcagaagg aaaacagcaa     9600

gcgctggaac ccggagatcc agtacacttc caactattac aagtctaata atgttgaatt     9660

tgctgttaat actgaaggtg tatatagtga accccgcccc attggcacca gatacctgac     9720

tcgtaatctg taattgcttg ttaatcaata aaccgtttaa ttcgtttcag ttgaactttg     9780

gtctctgcgg tttaaacggt cctgtattag aggtcacgtg agtgttttgc gacattttgc     9840

gacaccatgt ggtcacgctg ggtatttaag cccgagtgag cacgcagggt ctccattttg     9900

aagcgggagg tttgaacgcg cgcggccgcg tagtcccgca gtacgcggct aggcagatcg     9960

gccccttcca aatccgtgtc atcggaagac catgttggta gtttcataat ggattttatt    10020

gattgctatg taacctgaac gacggtatta atgggcttct taacatgaac gtgagtaacg    10080

gaaacattac gcttttcggt cgcgaatgac ggcgaactct gggccttgtg ggattataga    10140

tacgtcagtg ttcctcggga acggacaaag taggaaatat cgacgacatg gatcatgcca    10200

atatatcaac gcgggaagat gaccattgat gcagtgggaa ctggtgtccc acaaatatct    10260

agggcttgtg cagcggtcaa gggctgtgtt ccacctggga cgccagccca attatacgcc    10320

agaaacgctt gattttactc aggtagaaag ggggaaaata cactacgcga ccaactaata    10380

attcctttcg caaacttaat ggctgctaat tttcctcaag accggcttaa tgcctactac    10440

acttaaggcg cggatggcga gatacgacgc gggcacatac taggcacgtc atcggccagg    10500

cgttctaatt taagttcacg cataaataag cgtctctcga gactgcagat ccccgtctta    10560

aatttagtac acaacgctgt ttaccaccgg ggcgttatga cttgcagacc cgtgcgtgaa    10620

tatcctgtat cattcatcac tgctgggact accccacttt acatatctaa gggattcaac    10680

aaacttcggg tggttaatgt caagtgcgtt attggcgtat aacagggtga atgcacattg    10740

atggaatgcc ttcaaccaag ctgtggcgtc acgccagccg aacacgtttt acccaaactt    10800

agcccttttg ctgcgaccct gctatctatt ggctatactc tatatgcaat gggtgcagat    10860

cggagaccgc gccattgtca ccaccccaag gaggggagat tcacgctcgc tcggattagc    10920

ttcccggatc atttatcaaa actggaaata ctctaagcta agttcacctt cagatccttg    10980

tcaagagttg tcggcccgat tagtcgttgc gcacacgtgg cgtaattaca gcacgcgagg    11040

tacattcgag tttatcctct gggctccatt caggcaatat gctgtcagca cgaagagtgt    11100

gacctggcgc tattgttggc gacttgacgc cacggaatac cagtgtatat acatcctagg    11160

agaactgcaa gacttcgggc gtgtatcgta ggttatggta gtcactggga tttgcacctg    11220

cgcacaatct gtttggtaaa gtaaaagcga tacttcgcga ctcccaataa gtaacgatac    11280

tgcgcggcat cccttagcgc tctcataccg agcgagatac agtctatata ctcaacagag    11340

cacgtttgga acctgtgagg ttcagcacca atcattcatc tataaactca tcgagaaaag    11400

tatggaggcc acgtgggctt cttcggttca gctaagcaga ctcatgaggg tgtggtctcg    11460

gctttggagg cagatattgt ccggaattgt aattgcgact gcgcggcagt atagagtgtc    11520

tctatcattg taggactcac gcacccatcg gacaaccacg tgatggcccc ttagttatat    11580

cgagggatag gggctatgct caagttagtc ttaatttcgc gtgcttgcaa ggcttatcgc    11640

cggtccctcc taccgtaccc ggcctttcag ggccatgatc tttgcctgct tccctgttta    11700

tctacaccaa tattgggaga cttgtatgac gagcgagcca ctaaagagga cgattgtcaa    11760

cagggtgctt tatcacataa tagcctgttt ctccaacagt gcttcaatta cctagcatca    11820

cagaatgcga taagcccacc acgtgtttcc caatggcggc tattcattaa tcgggacgac    11880

acccctattc gtggagagag catcctattg agtccgagct gttagcgcat gattacggtg    11940

ggccagacag attcgacgga atgccgctac tacgctggcg cgtaatcagt cggaaccaga    12000

attaattaac ctgcaggcag ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc    12060

ccgggcgtcg ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg    12120

gagtggccaa ctccatcact aggggttcct tctagacgtg aggctccggt gcccgtcagt    12180

gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa    12240

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc    12300

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc    12360

tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt tcccgcgggc    12420

ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg cccctggctg    12480

cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag ttcgaggcct    12540

tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcctgg gcgctggggc    12600

cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga taagtctcta    12660

gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga tagtcttgta    12720

aatgcgggcc aagatctgca cactggtatt tcggtttttg gggccgcggg cggcgacggg    12780

gcccgtgcgt cccagcgctc atgttcggcg aggcggggcc tgcgagcgcg gccaccgaga    12840

atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct cgcgccgccg    12900

tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc gtgagcggaa    12960

agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg gcgctcggga    13020

gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc agccgtcgct    13080

tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt ctcgagcttt    13140

tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt tccccacact    13200

gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc cttggaattt    13260

gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt tcaaagtttt    13320

tttcttccat ttcaggtgtc gtgagccacc atggtgagca agggcgagga ggataacatg    13380

gccatcatca aggagttcat gcgcttcaag gtgcacatgg agggctccgt gaacggccac    13440

gagttcgaga tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag    13500

ctgaaggtga ccaagggtgg ccccctgccc ttcgcctggg acatcctgtc ccctcagttc    13560

atgtacggct ccaaggccta cgtgaagcac cccgccgaca tccccgacta cttgaagctg    13620

tccttccccg agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgtggtg    13680

accgtgaccc aggactcctc cctgcaggac ggcgagttca tctacaaggt gaagctgcgc    13740

ggcaccaact tcccctccga cggccccgta atgcagaaga agaccatggg ctgggaggcc    13800

tcctccgagc ggatgtaccc cgaggacggc gccctgaagg gcgagatcaa gcagaggctg    13860

aagctgaagg acggcggcca ctacgacgct gaggtcaaga ccacctacaa ggccaagaag    13920

cccgtgcagc tgcccggcgc ctacaacgtc aacatcaagt tggacatcac ctcccacaac    13980

gaggactaca ccatcgtgga acagtacgaa cgcgccgagg gccgccactc caccggcggc    14040

atggacgagc tgtacaagta agtcgactac tggccgaagc cgcttggaat aaggccggtg    14100

tgcgtttgtc tatatgtgat tttccaccat attgccgtct tttggcaatg tgagggcccg    14160

gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg    14220

aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca    14280

aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct    14340

ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca    14400

cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa    14460

ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggtg    14520

cacatgcttt acatgtgttt agtcgaggtt aaaaaacgtc taggcccccc gaaccacggg    14580

gacgtggttt tcctttgaaa aacacgatcg tacggccacc atgtggggag cctgcttgct    14640

gctgctgggc ctcagcctac aggtgtgccc gagcgtcatc ccagtggagg aggagaatcc    14700

agccttctgg aaccgaaagg cagccgaggc cctggatgct gccaagaagc tgaagcccat    14760

tcagacatca gctaagaacc tcgttatcct catgggagat gggatggggg tgtctacagt    14820

aaccgctacc cggatcttaa aggggcagca gcaaggccat ctgggacctg agacacagtt    14880

agctatggat cgctttccac acatggctct gtccaagaca tacaacacag acaagcagat    14940

cccggacagc gcaggcacag gtacagcctt tctctgcggg gtcaaaacca acatgaaggt    15000

cattggcttg agtgcagctg cacgcttcaa ccagtgcaac acgacatggg gtaacgaggt    15060

cgtctcggtg atgcaccgtg ctaagaaagc aggaaagtct gtgggagtgg tgaccaccac    15120

gtcggtgcag catgcttctc cggccggcac ctacgcgcac actgtgaacc gtggttggta    15180

ctcggatgca caaatgcctg cctcagcgct acaggatggc tgcaaagaca tctctactca    15240

gctcatctcc aacatggaca ttgatgtgat cctcggtggt ggccgcaagt tcatgtttcc    15300

caaggggaca ccagaccagg aatatccaac tgacaccaag caggctggaa ccaggctgga    15360

tggacgcaac ctagttcaag agtggctggc aaagcaccag ggagcccggt atgtttggaa    15420

ccgctcagag ctgattcagg catccctgaa ccgatctgtg acacacctca tgggcctctt    15480

tgagcctaac gacatgaaat atgaaatcca ccgagaccct gctcaggacc cttccctggc    15540

cgagatgacg gaggtggctg tgcgcatgct cagcaggaac cccaaaggct tctatctctt    15600

tgtggaaggg ggtcgcatcg accatggcca ccatgaaact gtagcctatc gtgccctgac    15660

tgaggctgtc atgttcgact cggctgttga caaggcagac aagctcacca gtgagcagga    15720

cacgatgatc cttgtcactg ccgaccactc tcacgtcttc tcttttggtg gttacacaca    15780

gagaggggct tccatctttg gactggctcc cttcaaggct gaggatggca aatcctttac    15840

ctcgatacta tacggcaacg gtcctggtta caagctccat aatggcgccc gggctgatgt    15900

cactgaggaa gagagcagca accccacgta ccagcagcag gctgctgtac ccctgtcgtc    15960

agagacccac agcggggagg acgtggcaat attcgcgcgt ggcccacagg cgcagctggt    16020

gcacggagtt caggagcaga actacatcgc gcacgtcatg gccttcgcag cctgcctgga    16080

gccctacact gactgcggcc tggcatcccc tgctggccag agcagtgcag tgagcccggg    16140

ctgaacgcgt gggggaggct aactgaaaca cggaaggaga caataccgga aggaacccgc    16200

gctatgacgg caataaaaag acagaataaa acgcacggtg ttgggtcgtt tgttcataaa    16260

cgcggggttc ggtcccaggg ctggcactct gtcgataccc caccgagacc ccattggggc    16320

caatacgccc gcgtttcttc cttttcccca ccccaccccc caagttcggg tgaaggccca    16380

gggctcgcag ccaacgtcgg ggcggcaggc cctgccatag ccatctatgt cgggtgcgga    16440

gaaagaggta ataggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct    16500

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct    16560

cagtgagcga gcgagcgcgc agctgcctgc aggttaatta acctgcaggt gtacacaatg    16620

atacgatccc gtttctgcga cgtactcggg tgtagctggg accctgtcgc atttaatcgc    16680

cggtcaatag gtacaccgtg ctgatcttgg atactcctga tcgcgatgta acccgagcgg    16740

cgctactaat gggcgtccta acacgagcgc gaataaccac ttgcgctagg caggatttac    16800

gatggtcatc tggaacggac gggtacacca tgccaaaatt tgctcctagt tcacaaggtc    16860

aaacggtgac ccggaggcca gtccactcct tgtcctcgtc cttacgttac cgtaacctct    16920

gacctggagc ctaaggctgc tccggcattt taaaaaccac acaaataagg cttcacacta    16980

ttcctattat cttgtgtcct acctaagagg tagtggagcg agtaggtaga cacaggcact    17040

caccaccgat gttccgccca tgggccatgg ttaaggtccg aatgaaaccc gtatgcaagt    17100

taccggcctt atattaataa ggttggtata catcctaaaa gctctctcgg acgtgaccaa    17160

atacaggcat ccacggagca ctactgaatg ggcacgtgga ccggcgagtg agaaatcgag    17220

cagcattaag tcattcttag taagccgaga tgggtctgcg ttatgtacgt ctagtgggga    17280

aacaagttgg tggacaaacg ttacgcctaa ggagctaata tttcggtcag gttgcgctgg    17340

gtcaaatcaa ccggtcctgg taacggagcg atggttaggt gtattacact agcgatgggc    17400

cgtgccggat ggtacgccac gttctccgag ccagtgaaat tggatgagaa ctcgtaaatc    17460

tctcgttgca aacagcttcc tcaatatatg acctggccac tgatgagagg gtaacactta    17520

attcctagaa tgtctgacga catcaccctt aagcagacac actgcgatgt gtggacgcta    17580

gggtgtctct ttccacgttt gacttagccc atgatgtctt gactaagatg gcagggtatt    17640

tccccttatt cgtgtatgta ccactattac cgtcgattga ccgtcgccgc ttatacgtcg    17700

tgccctgtgc cttggcaatt ttgtccctgg ataacccgcc ttgcttctat cgaggtcctt    17760

gaataagtta atgcaacttg tggaggaaca tagggaatgt ggcgtgctgc ttagatatgg    17820

agtgcaagaa gtcctctggg ttgtagtttc actgttacgt cctagccagt gaagcactgg    17880

catgcagctt tatctgagga ttccactcac tgcttacaag aatttgccaa gctggtgccg    17940

atatgacccc aacgctatcc agagtttaag ttgtcatctc tctccatcat aattgccaca    18000

gtgtgttgtg tctacgaata gctattaaaa taccagcccc tgagaacgat gcccgacaca    18060

tagggcagtg caggcagcat aacgtgcaga tcaacataat ttccactaag tgttgatata    18120

gtttactggc tgagagccgc catattggaa cgacgacgag agcgcgtatc ctgcccaacc    18180

agaaatacgt gtccaatcca tataactgac caaagctgcg gacagtttcc tctccaccta    18240

caacgggatt agcgcacttg cttgtagtga ggcaggtata acccacggca cgtaacacct    18300

ttagacgttc ggttccgcaa tcgcacaatg tactactatt agagaactat agcaaggaac    18360

ttatagcgta tcgaaagttc atccctgcgg cccatagccg taaccaccgt ggggttattt    18420

taaactttaa gttgtaccct caggcaagcg aagaccggta ctttacctac atggggccgc    18480

tttccgagcc acgccgcacc ccaacatatt cctacgcgct gtaataatga acataagaga    18540

aaatggagtt gggtgacagc acatatcgac tacctagcga ctaccgcaac acaaagtaga    18600

tcccgccggt atcctccttt catgcaggac gggttaccca ggaatgcgtt tgtttgactg    18660

gtgcccgctg aggcgctgaa tatctcgcga tagcgtgtac cgatcaagaa agcactccgg    18720

gatatctggc aaacagctat tatgggtatt atgggtttca gggagtggcg cagctgcttc    18780

atccccgtgg cccgttgctc gcgtttgctg gcggtgtccc cggaagaaat atatttgcat    18840

gtctttagtt ctatgatgac acaaaccccg cccagcgtct tgtcattggc gaaaacacgc    18900

agatgcagtc ggggcggcgc ggtcccaggt ccacttcgca tattaaggtg acgcgtgtgg    18960

cctcgaacac agagcgacgg ccaccatgac cgagtacaag cccacggtgc gcctcgccac    19020

ccgcgacgac gtcccccggg ccgtacgcac cctcgccgcc gcgttcgccg actaccccgc    19080

cacgcgccac accgttgacc cggaccgcca catcgagcgg gtcaccgagc tgcaagaact    19140

cttcctcacg cgcgtcgggc tcgacatcgg caaggtgtgg gtcgcggacg acggcgccgc    19200

ggtggcggtc tggaccacgc cggagagcgt cgaagcgggg gcggtgttcg ccgagatcgg    19260

cccgcgcatg gccgagttga gcggttcccg gctggccgcg cagcaacaga tggaaggcct    19320

cctggcgccg caccggccca aggagcccgc gtggttcctg gccaccgtcg gcgtctcgcc    19380

cgaccaccag ggcaagggtc tgggcagcgc cgtcgtgctc cccggagtgg aggcggccga    19440

gcgcgccggg gtgcccgcct tcctggagac ctccgcgccc cgcaacctcc ccttctacga    19500

gcggctcggc ttcaccgtca ccgccgacgt cgaggtgccc gaaggaccgc gcacctggtg    19560

catgacccgc aagcccggtg cctgatgtgc cttctagttg ccagccatct gttgtttgcc    19620

cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa    19680

atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg    19740

ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg    19800

gctctatggt cccccttatt aaccctaaac gggtagcata tgcttcccgg gtagtagtat    19860

atactatcca gactaaccct aattcaatag catatgttac ccaacgggaa gcatatgcta    19920

tcgaattagg gttagtaaaa gggtcctaag gaacagcgat ctggatagca tatgctatcc    19980

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagca taggctatcc    20040

taatctatat ctgggtagca tatgctatcc taatctatat ctgggtagta tatgctatcc    20100

taatttatat ctgggtagca taggctatcc taatctatat ctgggtagca tatgctatcc    20160

taatctatat ctgggtagta tatgctatcc taatctgtat ccgggtagca tatgctatcc    20220

tcatgcatat acagtcagca tatgataccc agtagtagag tgggagtgct atcctttgca    20280

tatgccgcca cctcccaagg attatgggtg acgtcaggtg gcacttttcg gggaaatgtg    20340

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga    20400

caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat    20460

ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca    20520

gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc    20580

gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca    20640

atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg    20700

caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca    20760

gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata    20820

accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag    20880

ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg    20940

gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca    21000

acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta    21060

atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct    21120

ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca    21180

gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag    21240

gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat    21300

tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt    21360

taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa    21420

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga    21480

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg    21540

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc    21600

agagcgcaga taccaaatac tgttcttcta gtgtagccgt agttaggcca ccacttcaag    21660

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc    21720

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg    21780

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac    21840

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga    21900

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt    21960

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag    22020

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg    22080

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgt                   22126


<210>  71
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-Actin Splice Donor

<400>  71
gtggatccag gtgggtgtc                                                    19


<210>  72
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-Actin Splice Acceptor

<400>  72
ccctcctcag gaggaccag                                                    19


<210>  73
<211>  863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated 5' portion of the AAV2 rep gene upstream of the stop 
       cassette in the exemplified construct

<400>  73
ggtcctgtat tagaggtcac gtgagtgttt tgcgacattt tgcgacacca tgtggtcacg       60

ctgggtattt aagcccgagt gagcacgcag ggtctccatt ttgaagcggg aggtttgaac      120

gcgcagccgc catgccgggg ttttacgaga ttgtgattaa ggtccccagc gaccttgacg      180

agcatctgcc cggcatttct gacagctttg tgaactgggt ggccgagaag gaatgggagt      240

tgccgccaga ttctgacatg gatctgaatc tgattgagca ggcacccctg accgtggccg      300

agaagctgca gcgcgacttt ctgacggaat ggcgccgtgt gagtaaggcc ccggaggccc      360

ttttctttgt gcaatttgag aagggagaga gctacttcca catgcacgtg ctcgtggaaa      420

ccaccggggt gaaatccatg gttttgggac gtttcctgag tcagattcgc gaaaaactga      480

ttcagagaat ttaccgcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga      540

ccagaaatgg cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact      600

tgctccccaa aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa      660

gcgcctgttt gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt      720

cgcagacgca ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca      780

gatcaaaaac ttcagccaga tacatggagc tggtcgggtg gctcgtggac aaggggatta      840

cctcggagaa gcagtggatc cag                                              863

