                         SEQUENCE LISTING

<110>  ҩҵ޹˾
 
<120>  CTLA4-PD-1˫Կ弰;

<130>  IEC200176PCT

<150>  CN201910711122.4
<151>  2019-08-02

<150>  CN201911224135.5
<151>  2019-12-02

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  4G10ɱĺ

<400>  1
caggtcaagc tgcaggagtc tggacctgag ctggtgaagc ctggagcttc aatgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctacacca tgaactgggt gaagcagagc      120

catggaaaga accttgaatg gattggactt attaatcctt acaataatat tactaactac      180

aaccagaagt tcatgggcaa ggccacattt actgtagaca agtcatccag cacagcctac      240

atggaactcc tcagactgac atctgaagac tctggagtct atttctgtgc aagactcgac      300

tataggtctt attggggcca agggactctg gtcactgtct ctgcagccaa aacgacaccc      360

ccatctgtct at                                                          372


<210>  2
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  4G10ɱİ

<400>  2

Gln Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Asn Ile Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Phe Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Arg Leu Thr Ser Glu Asp Ser Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Arg Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 


<210>  3
<211>  378
<212>  DNA
<213>  Artificial

<220>
<223>  4G10ɱĺ

<400>  3
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact ttgccaactg ggtccaagaa      120

aaaccagatc atttattcac tagtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ttgggtgttc      300

ggtggaggaa ccaaactgac tgtcctaggc cagcccaagt cttcgccatc agtcaccctg      360

tttcaagggc aattctgc                                                    378


<210>  4
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  4G10ɱİ

<400>  4

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Phe Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Ser 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ser Ser Pro Ser Val Thr Leu Phe Gln Gly Gln Phe Cys 
        115                 120                 125     


<210>  5
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  4G10H1Vĺ

<400>  5
caggtgcagc tggtggagtc tggggccgag ctggtgaagc ccggcgcctc catgaagatc       60

tcttgcaagg ccagcggata cagtttcact ggctatacca tgaactgggt caaacaggct      120

ccaggacagg gactggagtg gatcgggctg attaatcctt acaacaacat caccaactac      180

aaccagaagt tcatgggaaa agcaaccttt acagtggaca agagcatttc cacagcctac      240

atggaactga gccggctgac ttcagacgat agcggggtct atttttgtgc aaggctggat      300

tatcgctctt actgggggca gggaactctg gtcactgtct ccgct                      345


<210>  6
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  4G10H1Vİ

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Asn Ile Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Phe Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Ser Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Arg Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  7
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  4G10L1Vĺ

<400>  7
caggctgtcg tcactcagga accttcactg actgtgagcc caggaggaac tgtcaccctg       60

acatgcggaa gctccaccgg agcagtgacc acatccaact tcgccaattg ggtccaggaa      120

aagccaggcc aggcatttcg atccctgatc ggaggcacaa acaatcgggc ttcttgggtg      180

cccgcaagat tctcaggaag cctgctgggg ggaaaagccg ctctgaccat tagtggcgct      240

cagcctgagg acgaagccga gtacttctgc gctctgtggt atagcaacca ctgggtgttt      300

ggcgggggaa caaagctgac tgtgctg                                          327


<210>  8
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  4G10L1Vİ

<400>  8

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Phe Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Ser 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Ser Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  9
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  4G10H3Vĺ

<400>  9
caggtgcagc tggtcgagtc tggggccgaa gtgaagaaac ccggcgcctc agtgaaggtc       60

agctgcaagg ccagcgggta cagtttcact ggatatacca tgaactgggt ccgacaggcc      120

cctggccagg ggctggagtg gatcggcctg attaaccctt acaacaacat cactaactac      180

gcacagaagt tccaggggag agtgaccttt acagtggaca ccagcatttc cacagcctac      240

atggaactgt cccggctgag atctgacgat acaggcgtgt acttctgcgc taggctggat      300

taccgcagct attggggaca gggcacactg gtgactgtca gcgca                      345


<210>  10
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  4G10H3Vİ

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Asn Ile Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Arg Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  11
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  4G10L3Vĺ

<400>  11
caggctgtcg tcactcagga accttcactg accgtgtctc ctggcgggac tgtcaccctg       60

acatgcggca gctccacagg ggccgtgacc acaagtaact tcccaaattg ggtccagcag      120

aagccaggac aggctccccg gagtctgatc ggaggcacca acaacaaggc cagctggaca      180

cccgcacggt tcagcggcag cctgctgggc ggcaaggccg ctctgacaat tagcggagcc      240

cagcctgagg acgaagccga gtactattgc gctctgtggt actccaacca ctgggtgttc      300

ggcggcggca ccaagctgac tgtgctg                                          327


<210>  12
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  4G10L3Vİ

<400>  12

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Phe Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Lys Ala Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  13
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  14C12ɱĺ

<400>  13
gaggtcaaac tggtggagag cggcggcggg ctggtgaagc ccggcgggtc actgaaactg       60

agctgcgccg cttccggctt cgcctttagc tcctacgaca tgtcatgggt gaggcagacc      120

cctgagaagc gcctggaatg ggtcgctact atcagcggag gcgggcgata cacctactat      180

cctgactctg tcaaagggag attcacaatt agtcgggata acgccagaaa tactctgtat      240

ctgcagatgt ctagtctgcg gtccgaggat acagctctgt actattgtgc aaaccggtac      300

ggcgaagcat ggtttgccta ttggggacag ggcaccctgg tgacagtctc tgcc            354


<210>  14
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  14C12ɱİ

<400>  14

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  15
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  14C12ɱĺ

<400>  15
gacattaaga tgacacagtc cccttcctca atgtacgcta gcctgggcga gcgagtgacc       60

ttcacatgca aagcatccca ggacatcaac acatacctgt cttggtttca gcagaagcca      120

ggcaaaagcc ccaagaccct gatctaccgg gccaatagac tggtggacgg ggtccccagc      180

agattctccg gatctggcag tgggcaggat tactccctga ccatcagctc cctggagtat      240

gaagacatgg gcatctacta ttgcctgcag tatgatgagt tccctctgac ctttggagca      300

ggcacaaaac tggaactgaa g                                                321


<210>  16
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  14C12ɱİ

<400>  16

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Phe Thr Cys Lys Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  17
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  14C12H1L1ɱĺ

<400>  17
gaagtgcagc tggtcgagtc tgggggaggg ctggtgcagc ccggcgggtc actgcgactg       60

agctgcgcag cttccggatt cgcctttagc tcctacgaca tgtcctgggt gcgacaggca      120

ccaggaaagg gactggattg ggtcgctact atctcaggag gcgggagata cacctactat      180

cctgacagcg tcaagggccg gttcacaatc tctagagata acagtaagaa caatctgtat      240

ctgcagatga acagcctgag ggctgaggac accgcactgt actattgtgc caaccgctac      300

ggggaagcat ggtttgccta ttgggggcag ggaaccctgg tgacagtctc tagt            354


<210>  18
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1L1ɱİ

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  19
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  14C12H1L1ɱĺ

<400>  19
gacattcaga tgactcagag cccctcctcc atgtccgcct ctgtgggcga cagggtcacc       60

ttcacatgcc gcgctagtca ggatatcaac acctacctga gctggtttca gcagaagcca      120

gggaaaagcc ccaagacact gatctaccgg gctaatagac tggtgtctgg agtcccaagt      180

cggttcagtg gctcagggag cggacaggac tacactctga ccatcagctc cctgcagcct      240

gaggacatgg caacctacta ttgcctgcag tatgatgagt tcccactgac ctttggcgcc      300

gggacaaaac tggagctgaa g                                                321


<210>  20
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1L1ɱİ

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Met Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  21
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  14C12H1DNA

<400>  21
gaagtgcagc tggtcgagtc tgggggaggg ctggtgcagc ccggcgggtc actgcgactg       60

agctgcgcag cttccggatt cgcctttagc tcctacgaca tgtcctgggt gcgacaggca      120

ccaggaaagg gactggattg ggtcgctact atctcaggag gcgggagata cacctactat      180

cctgacagcg tcaagggccg gttcacaatc tctagagata acagtaagaa caatctgtat      240

ctgcagatga acagcctgag ggctgaggac accgcactgt actattgtgc caaccgctac      300

ggggaagcat ggtttgccta ttgggggcag ggaaccctgg tgacagtctc tagtgccagc      360

accaaaggac ctagcgtgtt tcctctcgcc ccctcctcca aaagcaccag cggaggaacc      420

gctgctctcg gatgtctggt gaaggactac ttccctgaac ccgtcaccgt gagctggaat      480

agcggcgctc tgacaagcgg agtccataca ttccctgctg tgctgcaaag cagcggactc      540

tattccctgt ccagcgtcgt cacagtgccc agcagcagcc tgggcaccca gacctacatc      600

tgtaacgtca accacaagcc ctccaacacc aaggtggaca agaaagtgga gcccaaatcc      660

tgcgacaaga cacacacctg tcccccctgt cctgctcccg aactcctcgg aggccctagc      720

gtcttcctct ttcctcccaa acccaaggac accctcatga tcagcagaac ccctgaagtc      780

acctgtgtcg tcgtggatgt cagccatgag gaccccgagg tgaaattcaa ctggtatgtc      840

gatggcgtcg aggtgcacaa cgccaaaacc aagcccaggg aggaacagta caactccacc      900

tacagggtgg tgtccgtgct gacagtcctc caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tgtccaacaa ggctctccct gcccccattg agaagaccat cagcaaggcc     1020

aaaggccaac ccagggagcc ccaggtctat acactgcctc cctccaggga cgaactcacc     1080

aagaaccagg tgtccctgac ctgcctggtc aagggctttt atcccagcga catcgccgtc     1140

gagtgggagt ccaacggaca gcccgagaat aactacaaga ccacccctcc tgtcctcgac     1200

tccgacggct ccttcttcct gtacagcaag ctgaccgtgg acaaaagcag gtggcagcag     1260

ggaaacgtgt tctcctgcag cgtgatgcac gaagccctcc acaaccacta cacccagaaa     1320

agcctgtccc tgagccccgg caaa                                            1344


<210>  22
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  14C12H1İ

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  23
<211>  642
<212>  DNA
<213>  Artificial

<220>
<223>  14C12L1DNA

<400>  23
gacattcaga tgactcagag cccctcctcc atgtccgcct ctgtgggcga cagggtcacc       60

ttcacatgcc gcgctagtca ggatatcaac acctacctga gctggtttca gcagaagcca      120

gggaaaagcc ccaagacact gatctaccgg gctaatagac tggtgtctgg agtcccaagt      180

cggttcagtg gctcagggag cggacaggac tacactctga ccatcagctc cctgcagcct      240

gaggacatgg caacctacta ttgcctgcag tatgatgagt tcccactgac ctttggcgcc      300

gggacaaaac tggagctgaa gcgaactgtg gccgctccct ccgtcttcat ttttccccct      360

tctgacgaac agctgaaatc aggcacagcc agcgtggtct gtctgctgaa caatttctac      420

cctagagagg caaaagtgca gtggaaggtc gataacgccc tgcagtccgg caacagccag      480

gagagtgtga ctgaacagga ctcaaaagat agcacctatt ccctgtctag tacactgact      540

ctgtccaagg ctgattacga gaagcacaaa gtgtatgcat gcgaagtgac acatcaggga      600

ctgtcaagcc ccgtgactaa gtcttttaac cggggcgaat gt                         642


<210>  24
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  14C12L1İ

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Phe Thr Cys Arg Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Met Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  25
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker1İ

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Linker2İ

<400>  26

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR1

<400>  27

Gly Phe Ala Phe Ser Ser Tyr Asp 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR2

<400>  28

Ile Ser Gly Gly Gly Arg Tyr Thr 
1               5               


<210>  29
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR3

<400>  29

Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  30
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR1

<400>  30

Gln Asp Ile Asn Thr Tyr 
1               5       


<210>  31
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR2

<400>  31

Arg Ala Asn 
1           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR3

<400>  32

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  33
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR1

<400>  33

Gly Tyr Ser Phe Thr Gly Tyr Thr 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR2

<400>  34

Ile Asn Pro Tyr Asn Asn Ile Thr 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HCDR3

<400>  35

Ala Arg Leu Asp Tyr Arg Ser Tyr 
1               5               


<210>  36
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR1

<400>  36

Thr Gly Ala Val Thr Thr Ser Asn Phe 
1               5                   


<210>  37
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR2

<400>  37

Gly Thr Asn 
1           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LCDR3

<400>  38

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  39
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  BiAb004(hG1TM) 򵰰ײֵĺ

<400>  39
gaagtgcagc tggtcgagtc tgggggaggg ctggtgcagc ccggcgggtc actgcgactg       60

agctgcgcag cttccggatt cgcctttagc tcctacgaca tgtcctgggt gcgacaggca      120

ccaggaaagg gactggattg ggtcgctact atctcaggag gcgggagata cacctactat      180

cctgacagcg tcaagggccg gttcacaatc tctagagata acagtaagaa caatctgtat      240

ctgcagatga acagcctgag ggctgaggac accgcactgt actattgtgc caaccgctac      300

ggggaagcat ggtttgccta ttgggggcag ggaaccctgg tgacagtctc tagtgccagc      360

accaaagggc ccagcgtgtt tcctctcgcc ccctcctcca aaagcaccag cggaggaacc      420

gctgctctcg gatgtctggt gaaggactac ttccctgaac ccgtcaccgt gagctggaat      480

agcggcgctc tgacaagcgg agtccataca ttccctgctg tgctgcaaag cagcggactc      540

tattccctgt ccagcgtcgt cacagtgccc agcagcagcc tgggcaccca gacctacatc      600

tgtaacgtca accacaagcc ctccaacacc aaggtggaca agaaagtgga gcccaaatcc      660

tgcgacaaga cacacacctg tcccccctgt cctgctcccg aagctgctgg agcccctagc      720

gtcttcctct ttcctcccaa acccaaggac accctcatga tcagcagaac ccctgaagtc      780

acctgtgtcg tcgtggatgt cagccatgag gaccccgagg tgaaattcaa ctggtatgtc      840

gatggcgtcg aggtgcacaa cgccaaaacc aagcccaggg aggaacagta caactccacc      900

tacagggtgg tgtccgtgct gacagtcctc caccaggact ggctgaacgg caaggagtac      960

aagtgcaagg tgtccaacaa ggctctccct gcccccattg agaagaccat cagcaaggcc     1020

aaaggccaac ccagggagcc ccaggtctat acactgcctc cctccaggga cgaactcacc     1080

aagaaccagg tgtccctgac ctgcctggtc aagggctttt atcccagcga catcgccgtc     1140

gagtgggagt ccaacggaca gcccgagaat aactacaaga ccacccctcc tgtcctcgac     1200

tccgacggct ccttcttcct gtacagcaag ctgaccgtgg acaaaagcag gtggcagcag     1260

ggaaacgtgt tctcctgcag cgtgatgcac gaagccctcc acaaccacta cacccagaaa     1320

agcctgtccc tgagccccgg caaa                                            1344


<210>  40
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  BiAb004(hG1TM) 򵰰ײֵİ

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Arg Tyr Gly Glu Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  41
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  4G10H1V(M)

<400>  41

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ala Pro Gly Gln Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Asn Ile Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Phe Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Ser Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Arg Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  42
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  4G10L1V(M)

<400>  42

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Phe Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Ser 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Ser Trp Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Arg 
            100                 105                 110 


<210>  43
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  4G10H3V(M)

<400>  43

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Asn Ile Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Arg Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  44
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  4G10L3V(M)

<400>  44

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Phe Pro Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Lys Ala Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Arg 
            100                 105                 110 


