                         SEQUENCE LISTING

<110>  Capella Bioscience Ltd
 
<120>  Antigen binding molecules that bind BDCA-2

<130>  P116564WO

<150>  GB1911188.9
<151>  2019-08-05

<150>  GB2000814.0
<151>  2020-01-20

<160>  92

<170>  PatentIn version 3.5

<210>  1
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 3E05 VL

<400>  1

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Ser Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Cys Ala Ala Ser Thr Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 3E05 VL CDR 1 (Kabat and Chothia)

<400>  2

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Ser Met Asn 
1               5                   10                  15  


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 3E05 VL CDR 2 (Kabat and Chothia)

<400>  3

Ala Ala Ser Thr Leu Glu Ser 
1               5           


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 3E05 VL CDR 3 (Kabat and Chothia)

<400>  4

Gln Gln Thr Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  5
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 3E05 VH

<400>  5

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Tyr Tyr Asp Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 3E05 VH CDR 1 (Kabat)

<400>  6

Ser Tyr Thr Met Ser 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 3E05 VH CDR 2 (Kabat)

<400>  7

Tyr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 3E05 VH CDR 3 (Kabat and Chothia)

<400>  8

His Asp Tyr Tyr Asp Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 3E05 VH CDR 1 (Chothia)

<400>  9

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 3E05 VH CDR 2 (Chothia)

<400>  10

Ser Ser Gly Gly Gly Asn Thr Tyr 
1               5               


<210>  11
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_1

<400>  11

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Ser Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Ser Ala Ala Ser Thr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_1 CDR 1 (Kabat and Chothia)

<400>  12

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Ser Met Asn 
1               5                   10                  15  


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_1 CDR 2 (Kabat and Chothia)

<400>  13

Ala Ala Ser Thr Leu Glu Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_1 CDR 3 (Kabat and Chothia)

<400>  14

Gln Gln Thr Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  15
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_1

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Tyr Tyr Asp Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_1 CDR 1 (Kabat)

<400>  16

Ser Tyr Thr Met Ser 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_1 CDR 2 (Kabat)

<400>  17

Tyr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_1 CDR 3 (Kabat and Chothia)

<400>  18

His Asp Tyr Tyr Asp Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_1 CDR 1 (Chothia)

<400>  19

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_1 CDR 2 (Chothia)

<400>  20

Ser Ser Gly Gly Gly Asn Thr Tyr 
1               5               


<210>  21
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_2

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Ser Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Ser Ala Ala Ser Thr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_2 CDR 1 (Kabat and Chothia)

<400>  22

Lys Ser Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Ser Met Asn 
1               5                   10                  15  


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_2 CDR 2 (Kabat and Chothia)

<400>  23

Ala Ala Ser Thr Leu Glu Ser 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_2 CDR 3 (Kabat and Chothia)

<400>  24

Gln Gln Thr Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  25
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_2

<400>  25

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Tyr Tyr Asp Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_2 CDR 1 (Kabat)

<400>  26

Ser Tyr Thr Met Ser 
1               5   


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_2 CDR 2 (Kabat)

<400>  27

Tyr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_2 CDR 3 (Kabat and Chothia)

<400>  28

His Asp Tyr Tyr Asp Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_2 CDR 1 (Chothia)

<400>  29

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_2 CDR 2 (Chothia)

<400>  30

Ser Ser Gly Gly Gly Asn Thr Tyr 
1               5               


<210>  31
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_3

<400>  31

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Ser Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_3 CDR 1 (Kabat and Chothia)

<400>  32

Lys Ser Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Ser Met Asn 
1               5                   10                  15  


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_3 CDR 2 (Kabat and Chothia)

<400>  33

Ala Ala Ser Thr Leu Glu Ser 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_3 CDR 3 (Kabat and Chothia)

<400>  34

Gln Gln Thr Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  35
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_3

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Gln Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Tyr Tyr Asp Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_3 CDR 1 (Kabat)

<400>  36

Ser Tyr Thr Met Ser 
1               5   


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_3 CDR 2 (Kabat)

<400>  37

Tyr Ile Ser Ser Gly Gly Gly Gln Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_3 CDR 3 (Kabat and Chothia)

<400>  38

His Asp Tyr Tyr Asp Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_3 CDR 1 (Chothia)

<400>  39

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_3 CDR 2 (Chothia)

<400>  40

Ser Ser Gly Gly Gly Gln Thr Tyr 
1               5               


<210>  41
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_4

<400>  41

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Tyr Glu 
            20                  25                  30          


Gly Asp Ser Ser Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Ser Ala Ala Ser Thr Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_4 CDR 1 (Kabat and Chothia)

<400>  42

Lys Ala Ser Gln Ser Val Asp Tyr Glu Gly Asp Ser Ser Met Asn 
1               5                   10                  15  


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_4 CDR 2 (Kabat and Chothia)

<400>  43

Ala Ala Ser Thr Leu Glu Ser 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VL_4 CDR 3 (Kabat and Chothia)

<400>  44

Gln Gln Thr Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  45
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_4

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Gln Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Tyr Tyr Glu Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_4 CDR 1 (Kabat)

<400>  46

Ser Tyr Thr Met Ser 
1               5   


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_4 CDR 2 (Kabat)

<400>  47

Tyr Ile Ser Ser Gly Gly Gly Gln Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_4 CDR 3 (Kabat and Chothia)

<400>  48

His Asp Tyr Tyr Glu Gly Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_4 CDR 1 (Chothia)

<400>  49

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E05 VH_4 CDR 2 (Chothia)

<400>  50

Ser Ser Gly Gly Gly Gln Thr Tyr 
1               5               


<210>  51
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 21E06 VL

<400>  51

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Asn Cys Leu His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 21E06 VL CDR 1 (Kabat and Chothia)

<400>  52

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Asn Cys Leu His 
1               5                   10                  15  


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 21E06 VL CDR 2 (Kabat and Chothia)

<400>  53

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 21E06 VL CDR 3 (Kabat and Chothia)

<400>  54

Gln Gln Ser Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  55
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 21E06 VH

<400>  55

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ser Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Asp Asn Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Leu Tyr Tyr Gly Asp Tyr Phe Tyr Val Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 21E06 VH CDR 1 (Kabat)

<400>  56

Ser Tyr Thr Ile Ser 
1               5   


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 21E06 VH CDR 2 (Kabat)

<400>  57

Tyr Ile Ser Ser Gly Gly Asp Asn Ala Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 21E06 VH CDR 3 (Kabat and Chothia)

<400>  58

His Leu Tyr Tyr Gly Asp Tyr Phe Tyr Val Met Asp Tyr 
1               5                   10              


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 21E06 VH CDR 1 (Chothia)

<400>  59

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  60
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 21E06 VH CDR 2 (Chothia)

<400>  60

Ser Ser Gly Gly Asp Asn 
1               5       


<210>  61
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 25E06 VL

<400>  61

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Gly Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 25E06 VL CDR 1 (Kabat and Chothia)

<400>  62

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Gly Phe Met Asn 
1               5                   10                  15  


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 25E06 VL CDR 2 (Kabat and Chothia)

<400>  63

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 25E06 VL CDR 3 (Kabat and Chothia)

<400>  64

Gln Gln Ser Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  65
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 25E06 VH

<400>  65

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Gly Val Gly Gly Asp Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Phe Tyr Cys 
                85                  90                  95      


Ala Arg His His Tyr Ser His Tyr Phe Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 25E06 VH CDR 1 (Kabat)

<400>  66

Ser Tyr Thr Met Ser 
1               5   


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 25E06 VH CDR 2 (Kabat)

<400>  67

Tyr Ile Ser Gly Val Gly Gly Asp Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 25E06 VH CDR 3 (Kabat and Chothia)

<400>  68

His His Tyr Ser His Tyr Phe Trp Tyr Phe Asp Val 
1               5                   10          


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 25E06 VH CDR 1 (Chothia)

<400>  69

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 25E06 VH CDR 2 (Chothia)

<400>  70

Ser Gly Val Gly Gly Asp 
1               5       


<210>  71
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 28B01 VL

<400>  71

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Ala 
            20                  25                  30          


Gly Asp Ser Tyr Val Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 28B01 VL CDR 1 (Kabat and Chothia)

<400>  72

Lys Ala Ser Gln Ser Val Asp Tyr Ala Gly Asp Ser Tyr Val Asn 
1               5                   10                  15  


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 28B01 VL CDR 2 (Kabat and Chothia)

<400>  73

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 28B01 VL CDR 3 (Kabat and Chothia)

<400>  74

Gln Gln Ser Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  75
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 28B01 VH

<400>  75

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Asp Asn Ala Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His His Tyr Ser Asn Tyr Phe Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 28B01 VH CDR 1 (Kabat)

<400>  76

Tyr Tyr Thr Met Ser 
1               5   


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 28B01 VH CDR 2 (Kabat)

<400>  77

Tyr Ile Ser Ser Gly Gly Asp Asn Ala Tyr Tyr Pro Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 28B01 VH CDR 3 (Kabat and Chothia)

<400>  78

His His Tyr Ser Asn Tyr Phe Trp Tyr Phe Asp Val 
1               5                   10          


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 28B01 VH CDR 1 (Chothia)

<400>  79

Gly Phe Thr Phe Ser Tyr Tyr 
1               5           


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parental 28B01 VH CDR 2 (Chothia)

<400>  80

Ser Ser Gly Gly Asp Asn 
1               5       


<210>  81
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  81
atggtgcctg aagaagagcc tcaagaccga gagaaaggac tctggtggtt ccagttgaag       60

gtctggtcca tggcagtcgt atccatcttg ctcctcagtg tctgtttcac tgtgagttct      120

gtggtgcctc acaattttat gtatagcaaa actgtcaaga ggctgtccaa gttacgagag      180

tatcaacagt atcatccaag cctgacctgc gtcatggaag gaaaggacat agaagattgg      240

agctgctgcc caaccccttg gacttcattt cagtctagtt gctactttat ttctactggg      300

atgcaatctt ggactaagag tcaaaagaac tgttctgtga tgggggctga tctggtggtg      360

atcaacacca gggaagaaca ggatttcatc attcagaatc tgaaaagaaa ttcttcttat      420

tttctggggc tgtcagatcc agggggtcgg cgacattggc aatgggttga ccagacacca      480

tacaatgaaa atgtcacatt ctggcactca ggtgaaccca ataaccttga tgagcgttgt      540

gcgataataa atttccgttc ttcagaagaa tggggctgga atgacattca ctgtcatgta      600

cctcagaagt caatttgcaa gatgaagaag atctacatat aa                         642


<210>  82
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly Leu Trp Trp 
1               5                   10                  15      


Phe Gln Leu Lys Val Trp Ser Met Ala Val Val Ser Ile Leu Leu Leu 
            20                  25                  30          


Ser Val Cys Phe Thr Val Ser Ser Val Val Pro His Asn Phe Met Tyr 
        35                  40                  45              


Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln Tyr 
    50                  55                  60                  


His Pro Ser Leu Thr Cys Val Met Glu Gly Lys Asp Ile Glu Asp Trp 
65                  70                  75                  80  


Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser Cys Tyr Phe 
                85                  90                  95      


Ile Ser Thr Gly Met Gln Ser Trp Thr Lys Ser Gln Lys Asn Cys Ser 
            100                 105                 110         


Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Arg Glu Glu Gln Asp 
        115                 120                 125             


Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly Leu 
    130                 135                 140                 


Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp Gln Thr Pro 
145                 150                 155                 160 


Tyr Asn Glu Asn Val Thr Phe Trp His Ser Gly Glu Pro Asn Asn Leu 
                165                 170                 175     


Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Ser Glu Glu Trp Gly 
            180                 185                 190         


Trp Asn Asp Ile His Cys His Val Pro Gln Lys Ser Ile Cys Lys Met 
        195                 200                 205             


Lys Lys Ile Tyr Ile 
    210             


<210>  83
<211>  639
<212>  DNA
<213>  Cynomolgus

<400>  83
atggtgccag aggaggagcc acaggacaga gagaagggcg tgtggtggtt tcagctgaag       60

gtgtggagcg tggccgtggt gagcatcctg ctgctgtgcg tgtgctttac cgtgagcagc      120

gtggccagcc acaattttat gtatagcaag accgtgaaga gactgagcaa gctgcaggag      180

tatcagcagt attatccaag cctgacctgc gtgatggagg gcaaggacat ggaggactgg      240

agctgctgcc caaccccatg gaccagcttt cagagcagct gctattttat cagcaccgtg      300

atgcagagct ggaccaagag ccagaataat tgcagcgtga tgggcgccga cctggtggtg      360

atcaatacca aggaggagca ggactttatc acccagaatc tgaagatcaa tagcgcctat      420

tttctgggcc tgagcgaccc aaagggctgg agacactggc agtgggtgga ccagacccca      480

tataataaga atgtgacctt ttggcacagc ggcgagccaa atagcccaga cgagagatgc      540

gccatcatca attttagaag cgaggagtgg ggctggaatg acgtgcactg ccacgtgcca      600

cagaagagca tctgcaagat gaagaagatc tatatctaa                             639


<210>  84
<211>  212
<212>  PRT
<213>  Cynomolgus

<400>  84

Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly Val Trp Trp 
1               5                   10                  15      


Phe Gln Leu Lys Val Trp Ser Val Ala Val Val Ser Ile Leu Leu Leu 
            20                  25                  30          


Cys Val Cys Phe Thr Val Ser Ser Val Ala Ser His Asn Phe Met Tyr 
        35                  40                  45              


Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Gln Glu Tyr Gln Gln Tyr 
    50                  55                  60                  


Tyr Pro Ser Leu Thr Cys Val Met Glu Gly Lys Asp Met Glu Asp Trp 
65                  70                  75                  80  


Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser Cys Tyr Phe 
                85                  90                  95      


Ile Ser Thr Val Met Gln Ser Trp Thr Lys Ser Gln Asn Asn Cys Ser 
            100                 105                 110         


Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Lys Glu Glu Gln Asp 
        115                 120                 125             


Phe Ile Thr Gln Asn Leu Lys Ile Asn Ser Ala Tyr Phe Leu Gly Leu 
    130                 135                 140                 


Ser Asp Pro Lys Gly Trp Arg His Trp Gln Trp Val Asp Gln Thr Pro 
145                 150                 155                 160 


Tyr Asn Lys Asn Val Thr Phe Trp His Ser Gly Glu Pro Asn Ser Pro 
                165                 170                 175     


Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Glu Glu Trp Gly Trp 
            180                 185                 190         


Asn Asp Val His Cys His Val Pro Gln Lys Ser Ile Cys Lys Met Lys 
        195                 200                 205             


Lys Ile Tyr Ile 
    210         


<210>  85
<211>  525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  His-Human BDCA-2 DNA

<400>  85
catcatcatc accatcactt catgtacagc aagaccgtga agcggctgag caagctgaga       60

gagtaccagc agtaccaccc cagcctgacc tgcgtgatgg aaggcaagga catcgaggac      120

tggtcctgct gccctacccc ctggaccagc ttccagtcca gctgctactt catcagcacc      180

ggcatgcaga gctggaccaa gagccagaaa aactgcagcg tgatgggcgc cgacctggtc      240

gtgatcaaca ccagagagga acaggacttc atcatccaga acctgaagcg gaacagcagc      300

tacttcctgg gcctgagcga tcctggcggc agacggcatt ggcagtgggt ggaccagacc      360

ccctacaacg agaacgtgac cttctggcac agcggcgagc ccaacaacct ggacgagaga      420

tgcgccatca tcaacttccg gtccagcgag gaatggggct ggaacgacat ccactgccac      480

gtgccccaga aatccatctg caagatgaag aagatctaca tatga                      525


<210>  86
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-Human BDCA-2 protein

<400>  86

His His His His His His Phe Met Tyr Ser Lys Thr Val Lys Arg Leu 
1               5                   10                  15      


Ser Lys Leu Arg Glu Tyr Gln Gln Tyr His Pro Ser Leu Thr Cys Val 
            20                  25                  30          


Met Glu Gly Lys Asp Ile Glu Asp Trp Ser Cys Cys Pro Thr Pro Trp 
        35                  40                  45              


Thr Ser Phe Gln Ser Ser Cys Tyr Phe Ile Ser Thr Gly Met Gln Ser 
    50                  55                  60                  


Trp Thr Lys Ser Gln Lys Asn Cys Ser Val Met Gly Ala Asp Leu Val 
65                  70                  75                  80  


Val Ile Asn Thr Arg Glu Glu Gln Asp Phe Ile Ile Gln Asn Leu Lys 
                85                  90                  95      


Arg Asn Ser Ser Tyr Phe Leu Gly Leu Ser Asp Pro Gly Gly Arg Arg 
            100                 105                 110         


His Trp Gln Trp Val Asp Gln Thr Pro Tyr Asn Glu Asn Val Thr Phe 
        115                 120                 125             


Trp His Ser Gly Glu Pro Asn Asn Leu Asp Glu Arg Cys Ala Ile Ile 
    130                 135                 140                 


Asn Phe Arg Ser Ser Glu Glu Trp Gly Trp Asn Asp Ile His Cys His 
145                 150                 155                 160 


Val Pro Gln Lys Ser Ile Cys Lys Met Lys Lys Ile Tyr Ile 
                165                 170                 


<210>  87
<211>  1206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-Human BDCA-2 DNA

<400>  87
agctgcgaca agacccacac ctgtccccct tgtcctgccc ctgaactgct gggcggacct       60

agcgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa      120

gtgacctgcg tggtggtgga tgtgtcccac gaggaccctg aagtgaagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag      300

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgagaaaac catcagcaag      360

gccaagggcc agccccgcga accccaggtg tacacactgc cccctagcag ggacgagctg      420

accaagaacc aggtgtccct gacctgtctc gtgaagggct tctacccctc cgatatcgcc      480

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      540

gacagcgacg gctcattctt cctgtacagc aagctgacag tggacaagag ccggtggcag      600

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctgt ccttaagccc cggcaagatc gagggccggt tcatgtactc caagaccgtg      720

aagcggctgt ccaagctgag agagtaccag cagtaccacc ccagcctgac atgcgtgatg      780

gaaggcaagg acatcgagga ctggtcctgc tgccctaccc cctggaccag cttccagtcc      840

agctgctact tcatcagcac cggcatgcag agctggacaa agagccagaa aaactgctcc      900

gtgatgggcg ccgacctggt cgtgatcaac acccgcgagg aacaggactt catcatccag      960

aacctgaagc ggaacagcag ctacttcctg ggcctgagcg atcctggcgg cagacggcat     1020

tggcagtggg tggaccagac cccctacaac gagaacgtga ccttctggca cagcggcgag     1080

cccaacaacc tggacgagag atgcgccatc atcaacttcc ggtccagcga ggaatggggc     1140

tggaacgaca tccactgcca cgtgccccag aaatccatct gcaagatgaa gaagatctac     1200

atatga                                                                1206


<210>  88
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-Human BDCA-2 protein

<400>  88

Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys Ile Glu Gly Arg Phe Met Tyr Ser Lys Thr Val 
225                 230                 235                 240 


Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln Tyr His Pro Ser Leu 
                245                 250                 255     


Thr Cys Val Met Glu Gly Lys Asp Ile Glu Asp Trp Ser Cys Cys Pro 
            260                 265                 270         


Thr Pro Trp Thr Ser Phe Gln Ser Ser Cys Tyr Phe Ile Ser Thr Gly 
        275                 280                 285             


Met Gln Ser Trp Thr Lys Ser Gln Lys Asn Cys Ser Val Met Gly Ala 
    290                 295                 300                 


Asp Leu Val Val Ile Asn Thr Arg Glu Glu Gln Asp Phe Ile Ile Gln 
305                 310                 315                 320 


Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly Leu Ser Asp Pro Gly 
                325                 330                 335     


Gly Arg Arg His Trp Gln Trp Val Asp Gln Thr Pro Tyr Asn Glu Asn 
            340                 345                 350         


Val Thr Phe Trp His Ser Gly Glu Pro Asn Asn Leu Asp Glu Arg Cys 
        355                 360                 365             


Ala Ile Ile Asn Phe Arg Ser Ser Glu Glu Trp Gly Trp Asn Asp Ile 
    370                 375                 380                 


His Cys His Val Pro Gln Lys Ser Ile Cys Lys Met Lys Lys Ile Tyr 
385                 390                 395                 400 


<210>  89
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  89

Trp Leu Ala Phe Lys Leu Lys Leu Gly Thr Ala Ala Thr Met Gly Trp 
1               5                   10                  15      


Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly Val His Ser 
            20                  25                  30          


Gly Asp Ala Ser Phe Thr Arg Ile Arg Thr His Thr Leu Ser Gly Arg 
        35                  40                  45              


Gln Val Val Val Val Arg Leu Ala Ser Thr Lys Gly Pro Ser Val Phe 
    50                  55                  60                  


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
65                  70                  75                  80  


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                85                  90                  95      


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            100                 105                 110         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        115                 120                 125             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    130                 135                 140                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
145                 150                 155                 160 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                165                 170                 175     


Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            180                 185                 190         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        195                 200                 205             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    210                 215                 220                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ala Thr Tyr Arg Val 
225                 230                 235                 240 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                245                 250                 255     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Glu Glu Lys 
            260                 265                 270         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380                 


Lys 
385 


<210>  90
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8WTT0 construct

<400>  90

Met Val Pro Glu Glu Glu Pro Gln Asp Arg Glu Lys Gly Leu Trp Trp 
1               5                   10                  15      


Phe Gln Leu Lys Val Trp Ser Met Ala Val Val Ser Ile Leu Leu Leu 
            20                  25                  30          


Ser Val Cys Phe Thr Val Ser Ser Val Val Pro His Asn Phe Met Tyr 
        35                  40                  45              


Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln Tyr 
    50                  55                  60                  


His Pro Ser Leu Thr Cys Val Met Glu Gly Lys Asp Ile Glu Asp Trp 
65                  70                  75                  80  


Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser Cys Tyr Phe 
                85                  90                  95      


Ile Ser Thr Gly Met Gln Ser Trp Thr Lys Ser Gln Lys Asn Cys Ser 
            100                 105                 110         


Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Arg Glu Glu Gln Asp 
        115                 120                 125             


Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly Leu 
    130                 135                 140                 


Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp Gln Thr Pro 
145                 150                 155                 160 


Tyr Asn Glu Asn Val Thr Phe Trp His Ser Gly Glu Pro Asn Asn Leu 
                165                 170                 175     


Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Ser Glu Glu Trp Gly 
            180                 185                 190         


Trp Asn Asp Ile His Cys His Val Pro Gln Lys Ser Ile Cys Lys Met 
        195                 200                 205             


Lys Lys Ile Tyr Ile 
    210             


<210>  91
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q8WTT0-2 construct

<400>  91

Met Val Pro Glu Glu Glu Pro Gln Asp Arg Val Pro His Asn Phe Met 
1               5                   10                  15      


Tyr Ser Lys Thr Val Lys Arg Leu Ser Lys Leu Arg Glu Tyr Gln Gln 
            20                  25                  30          


Tyr His Pro Ser Leu Thr Cys Val Met Glu Gly Lys Asp Ile Glu Asp 
        35                  40                  45              


Trp Ser Cys Cys Pro Thr Pro Trp Thr Ser Phe Gln Ser Ser Cys Tyr 
    50                  55                  60                  


Phe Ile Ser Thr Gly Met Gln Ser Trp Thr Lys Ser Gln Lys Asn Cys 
65                  70                  75                  80  


Ser Val Met Gly Ala Asp Leu Val Val Ile Asn Thr Arg Glu Glu Gln 
                85                  90                  95      


Asp Phe Ile Ile Gln Asn Leu Lys Arg Asn Ser Ser Tyr Phe Leu Gly 
            100                 105                 110         


Leu Ser Asp Pro Gly Gly Arg Arg His Trp Gln Trp Val Asp Gln Thr 
        115                 120                 125             


Pro Tyr Asn Glu Asn Val Thr Phe Trp His Ser Gly Glu Pro Asn Asn 
    130                 135                 140                 


Leu Asp Glu Arg Cys Ala Ile Ile Asn Phe Arg Ser Ser Glu Glu Trp 
145                 150                 155                 160 


Gly Trp Asn Asp Ile His Cys His Val Pro Gln Lys Ser Ile Cys Lys 
                165                 170                 175     


Met Lys Lys Ile Tyr Ile 
            180         


<210>  92
<211>  14
<212>  PRT
<213>  Homo Sapians

<400>  92

Thr Phe Trp His Ser Gly Glu Pro Asn Asn Leu Asp Glu Arg 
1               5                   10                  