                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       O'Rourke, Donald
       Yin, Yibo
       Binder, Zev
       Johnson, Laura
 
<120>  SYNTHETIC CARS TO TREAT IL13RA2 POSITIVE HUMAN AND CANINE TUMORS

<130>  046483-7275WO1(02354)

<150>  62/892,114
<151>  2019-08-27

<160>  198   

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 HCDR1

<400>  1

Thr Lys Tyr Gly Val His 
1               5       


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 HCDR2

<400>  2

Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 HCDR2

<400>  3

Gly Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
1               5                   10                  15      


Ser 
    


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 HCDR3

<400>  4

Asp His Arg Asp Ala Met Asp Tyr 
1               5               


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 LCDR1

<400>  5

Thr Ala Ser Leu Ser Val Ser Ser Thr Tyr Leu His 
1               5                   10          


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 LCDR2

<400>  6

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 LCDR3

<400>  7

His Gln Tyr His Arg Ser Pro Leu Thr 
1               5                   


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 VH

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 VL

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Thr Ala Ser Leu Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  10
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 scFv VHVL

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Thr Ala Ser Leu Ser Val 
145                 150                 155                 160 


Ser Ser Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
                165                 170                 175     


Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr His 
    210                 215                 220                 


Arg Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  11
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 scFv VLVH

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Thr Ala Ser Leu Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Ser Leu Thr Lys Tyr Gly Val His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Val Lys Trp Ala 
                165                 170                 175     


Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met Ser Arg Phe Thr Ile 
            180                 185                 190         


Ser Lys Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp His Arg Asp 
    210                 215                 220                 


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 HCDR1

<400>  12

Ser Arg Asn Gly Met Ser 
1               5       


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 HCDR2

<400>  13

Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 HCDR3

<400>  14

Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp 
1               5                   10          


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 HCDR3

<400>  15

Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val 
1               5                   10              


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 LCDR1

<400>  16

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 LCDR2

<400>  17

Ser Ala Ser Tyr Arg Ser Thr 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 LCDR3

<400>  18

Gln His His Tyr Ser Ala Pro Trp Thr 
1               5                   


<210>  19
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 VH

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 VL

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  21
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 scFv VHVL

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser 
            180                 185                 190         


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Ser Phe Ile Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  22
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 scFv VLVH

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Thr Val Ser Ser Gly 
                165                 170                 175     


Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Thr Thr 
    210                 215                 220                 


Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  23
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 CAR VHVL

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Ser Leu Thr Lys Tyr Gly Val His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Gly Val Lys Trp Ala Gly Gly Ser Thr 
65                  70                  75                  80  


Asp Tyr Asn Ser Ala Leu Met Ser Arg Phe Thr Ile Ser Lys Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp His Arg Asp Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                165                 170                 175     


Cys Thr Ala Ser Leu Ser Val Ser Ser Thr Tyr Leu His Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn 
        195                 200                 205             


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Ser Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys His Gln Tyr His Arg Ser Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  24
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 CAR VHVL

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg Gln Thr Pro 
    50                  55                  60                  


Asp Lys Arg Leu Glu Trp Val Ala Thr Val Ser Ser Gly Gly Ser Tyr 
65                  70                  75                  80  


Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Thr Thr Ala Leu Ala 
        115                 120                 125             


Thr Arg Phe Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ser Gly Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 HCDR1

<400>  25

Gly Tyr Ser Ile Thr Ser Asp Phe Ala Trp Asn 
1               5                   10      


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 HCDR2

<400>  26

Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu Lys 
1               5                   10                  15      


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 HCDR3

<400>  27

Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp 
1               5                   10  


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 LCDR1

<400>  28

His Ser Ser Gln Asp Ile Asn Ser Asn Ile Gly 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 LCDR2

<400>  29

His Gly Thr Asn Leu Asp Asp 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 LCDR3

<400>  30

Val Gln Tyr Ala Gln Phe Pro Trp Thr 
1               5                   


<210>  31
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 VH

<400>  31

Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  32
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 VL

<400>  32

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  33
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 scFv VHVL

<400>  33

Gly Ala Thr Gly Thr Cys Cys Ala Gly Cys Thr Gly Cys Ala Ala Gly 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Cys Cys Cys Thr Ala Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Thr Cys Ala Ala Gly Cys Cys Thr Ala Gly Cys Cys Ala Gly 
        35                  40                  45              


Ala Gly Cys Cys Thr Gly Ala Gly Cys Cys Thr Gly Ala Cys Ala Thr 
    50                  55                  60                  


Gly Thr Ala Cys Cys Gly Thr Gly Ala Cys Cys Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Ala Gly Cys Ala Thr Cys Ala Cys Cys Ala Gly Cys Gly Ala Cys 
                85                  90                  95      


Thr Thr Cys Gly Cys Cys Thr Gly Gly Ala Ala Cys Thr Gly Gly Ala 
            100                 105                 110         


Thr Cys Ala Gly Ala Cys Ala Gly Thr Thr Cys Cys Cys Cys Gly Gly 
        115                 120                 125             


Cys Ala Ala Cys Ala Ala Gly Cys Thr Gly Gly Ala Ala Thr Gly Gly 
    130                 135                 140                 


Ala Thr Gly Gly Gly Cys Thr Ala Cys Ala Thr Cys Ala Gly Cys Thr 
145                 150                 155                 160 


Ala Cys Ala Gly Cys Gly Gly Cys Ala Ala Cys Ala Cys Cys Cys Gly 
                165                 170                 175     


Gly Thr Ala Cys Ala Ala Cys Cys Cys Cys Ala Gly Cys Cys Thr Gly 
            180                 185                 190         


Ala Ala Gly Thr Cys Cys Cys Gly Gly Ala Thr Cys Thr Cys Cys Ala 
        195                 200                 205             


Thr Cys Ala Cys Cys Ala Gly Ala Gly Ala Cys Ala Cys Cys Ala Gly 
    210                 215                 220                 


Cys Ala Ala Gly Ala Ala Cys Cys Ala Gly Thr Thr Cys Thr Thr Cys 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Cys Thr Gly Ala Ala Cys Ala Gly Cys Gly 
                245                 250                 255     


Thr Gly Ala Cys Cys Ala Thr Cys Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Cys Gly Cys Cys Ala Cys Cys Thr Ala Cys Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Thr Gly Ala Cys Ala Gly Cys Cys Gly Gly Cys Ala Gly Ala Gly 
    290                 295                 300                 


Gly Cys Thr Thr Cys Cys Cys Thr Thr Ala Thr Thr Gly Gly Gly Gly 
305                 310                 315                 320 


Ala Cys Ala Gly Gly Gly Ala Ala Cys Cys Cys Thr Gly Gly Thr Cys 
                325                 330                 335     


Ala Cys Ala Gly Thr Gly Thr Cys Thr Gly Cys Thr Gly Gly Thr Gly 
            340                 345                 350         


Gly Cys Gly Gly Ala Gly Gly Ala Thr Cys Thr Gly Gly Cys Gly Gly 
        355                 360                 365             


Ala Gly Gly Cys Gly Gly Ala Thr Cys Thr Thr Cys Thr Gly Gly Cys 
    370                 375                 380                 


Gly Gly Thr Gly Gly Cys Thr Cys Thr Gly Ala Thr Ala Thr Cys Cys 
385                 390                 395                 400 


Thr Gly Ala Thr Gly Ala Cys Ala Cys Ala Gly Ala Gly Cys Cys Cys 
                405                 410                 415     


Cys Ala Gly Cys Ala Gly Cys Ala Thr Gly Thr Cys Thr Gly Thr Gly 
            420                 425                 430         


Thr Cys Cys Cys Thr Gly Gly Gly Cys Gly Ala Thr Ala Cys Cys Gly 
        435                 440                 445             


Thr Gly Thr Cys Cys Ala Thr Cys Ala Cys Cys Thr Gly Thr Cys Ala 
    450                 455                 460                 


Cys Ala Gly Cys Ala Gly Cys Cys Ala Gly Gly Ala Cys Ala Thr Cys 
465                 470                 475                 480 


Ala Ala Cys Ala Gly Cys Ala Ala Cys Ala Thr Cys Gly Gly Cys Thr 
                485                 490                 495     


Gly Gly Cys Thr Gly Cys Ala Gly Cys Ala Gly Ala Gly Gly Cys Cys 
            500                 505                 510         


Thr Gly Gly Cys Ala Ala Gly Thr Cys Thr Thr Thr Thr Ala Ala Gly 
        515                 520                 525             


Gly Gly Cys Cys Thr Gly Ala Thr Cys Thr Ala Cys Cys Ala Cys Gly 
    530                 535                 540                 


Gly Cys Ala Cys Cys Ala Ala Cys Cys Thr Gly Gly Ala Thr Gly Ala 
545                 550                 555                 560 


Thr Gly Ala Gly Gly Thr Gly Cys Cys Cys Ala Gly Cys Ala Gly Ala 
                565                 570                 575     


Thr Thr Thr Thr Cys Cys Gly Gly Cys Thr Cys Thr Gly Gly Ala Ala 
            580                 585                 590         


Gly Cys Gly Gly Ala Gly Cys Cys Gly Ala Cys Thr Ala Cys Thr Cys 
        595                 600                 605             


Cys Cys Thr Gly Ala Cys Ala Ala Thr Cys Ala Gly Cys Ala Gly Cys 
    610                 615                 620                 


Cys Thr Gly Gly Ala Ala Ala Gly Cys Gly Ala Gly Gly Ala Cys Thr 
625                 630                 635                 640 


Thr Cys Gly Cys Cys Gly Ala Thr Thr Ala Cys Thr Ala Cys Thr Gly 
                645                 650                 655     


Cys Gly Thr Gly Cys Ala Gly Thr Ala Cys Gly Cys Cys Cys Ala Gly 
            660                 665                 670         


Thr Thr Thr Cys Cys Thr Thr Gly Gly Ala Cys Cys Thr Thr Thr Gly 
        675                 680                 685             


Gly Ala Gly Gly Cys Gly Gly Cys Ala Cys Ala Ala Ala Gly Cys Thr 
    690                 695                 700                 


Gly Gly Ala Ala Ala Thr Cys Ala Ala Gly Cys Gly Gly 
705                 710                 715         


<210>  34
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 scFv VHVL

<400>  34

Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val 
    130                 135                 140                 


Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp Ile 
145                 150                 155                 160 


Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe Lys 
                165                 170                 175     


Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln 
    210                 215                 220                 


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235                 


<210>  35
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806-BBZ-CAR

<400>  35
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg atgtccagct gcaagagtct ggccctagcc tggtcaagcc tagccagagc      120

ctgagcctga catgtaccgt gaccggctac agcatcacca gcgacttcgc ctggaactgg      180

atcagacagt tccccggcaa caagctggaa tggatgggct acatcagcta cagcggcaac      240

acccggtaca accccagcct gaagtcccgg atctccatca ccagagacac cagcaagaac      300

cagttcttcc tgcagctgaa cagcgtgacc atcgaggaca ccgccaccta ctactgtgtg      360

acagccggca gaggcttccc ttattgggga cagggaaccc tggtcacagt gtctgctggt      420

ggcggaggat ctggcggagg cggatcttct ggcggtggct ctgatatcct gatgacacag      480

agccccagca gcatgtctgt gtccctgggc gataccgtgt ccatcacctg tcacagcagc      540

caggacatca acagcaacat cggctggctg cagcagaggc ctggcaagtc ttttaagggc      600

ctgatctacc acggcaccaa cctggatgat gaggtgccca gcagattttc cggctctgga      660

agcggagccg actactccct gacaatcagc agcctggaaa gcgaggactt cgccgattac      720

tactgcgtgc agtacgccca gtttccttgg acctttggag gcggcacaaa gctggaaatc      780

aagcgggcta gcaccactac cccagcaccg aggccaccca ccccggctcc taccatcgcc      840

tcccagcctc tgtccctgcg tccggaggca tgtagacccg cagctggtgg ggccgtgcat      900

acccggggtc ttgacttcgc ctgcgatatc tacatttggg cccctctggc tggtacttgc      960

ggggtcctgc tgctttcact cgtgatcact ctttactgta agcgcggtcg gaagaagctg     1020

ctgtacatct ttaagcaacc cttcatgagg cctgtgcaga ctactcaaga ggaggacggc     1080

tgttcatgcc ggttcccaga ggaggaggaa ggcggctgcg aactgcgcgt gaaattcagc     1140

cgcagcgcag atgctccagc ctacaagcag gggcagaacc agctctacaa cgaactcaat     1200

cttggtcgga gagaggagta cgacgtgctg gacaagcgga gaggacggga cccagaaatg     1260

ggcgggaagc cgcgcagaaa gaatccccaa gagggcctgt acaacgagct ccaaaaggat     1320

aagatggcag aagcctatag cgagattggt atgaaagggg aacgcagaag aggcaaaggc     1380

cacgacggac tgtaccaggg actcagcacc gccaccaagg acacctatga cgctcttcac     1440

atgcaggccc tgccgcctcg gtga                                            1464


<210>  36
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806-BBZ-CAR

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro 
            20                  25                  30          


Ser Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr 
        35                  40                  45              


Gly Tyr Ser Ile Thr Ser Asp Phe Ala Trp Asn Trp Ile Arg Gln Phe 
    50                  55                  60                  


Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Asn 
65                  70                  75                  80  


Thr Arg Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Ile Glu 
            100                 105                 110         


Asp Thr Ala Thr Tyr Tyr Cys Val Thr Ala Gly Arg Gly Phe Pro Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Asp Ile Leu Met Thr Gln 
145                 150                 155                 160 


Ser Pro Ser Ser Met Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr 
                165                 170                 175     


Cys His Ser Ser Gln Asp Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln 
            180                 185                 190         


Arg Pro Gly Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu 
        195                 200                 205             


Asp Asp Glu Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  37
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806-KIR-CAR

<400>  37
atggggggac ttgaaccctg cagcaggttc ctgctcctgc ctctcctgct ggctgtaagt       60

ggtctccgtc ctgtccaggt ccaggcccag agcgattgca gttgctctac ggtgagcccg      120

ggcgtgctgg cagggatcgt gatgggagac ctggtgctga cagtgctcat tgccctggcc      180

gtgtacttcc tgggccggct ggtccctcgg gggcgagggg ctgcggaggc agcgacccgg      240

aaacagcgta tcactgagac cgagtcgcct tatcaggagc tccagggtca gaggtcggat      300

gtctacagcg acctcaacac acagaggccg tattacaaag tcgagggcgg cggagagggc      360

agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctag gatggcctta      420

ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc acgccgccag gccgggatcc      480

gatgtccagc tgcaagagtc tggccctagc ctggtcaagc ctagccagag cctgagcctg      540

acatgtaccg tgaccggcta cagcatcacc agcgacttcg cctggaactg gatcagacag      600

ttccccggca acaagctgga atggatgggc tacatcagct acagcggcaa cacccggtac      660

aaccccagcc tgaagtcccg gatctccatc accagagaca ccagcaagaa ccagttcttc      720

ctgcagctga acagcgtgac catcgaggac accgccacct actactgtgt gacagccggc      780

agaggcttcc cttattgggg acagggaacc ctggtcacag tgtctgctgg tggcggagga      840

tctggcggag gcggatcttc tggcggtggc tctgatatcc tgatgacaca gagccccagc      900

agcatgtctg tgtccctggg cgataccgtg tccatcacct gtcacagcag ccaggacatc      960

aacagcaaca tcggctggct gcagcagagg cctggcaagt cttttaaggg cctgatctac     1020

cacggcacca acctggatga tgaggtgccc agcagatttt ccggctctgg aagcggagcc     1080

gactactccc tgacaatcag cagcctggaa agcgaggact tcgccgatta ctactgcgtg     1140

cagtacgccc agtttccttg gacctttgga ggcggcacaa agctggaaat caagcgggct     1200

agcggtggcg gaggttctgg aggtgggggt tcctcaccca ctgaaccaag ctccaaaacc     1260

ggtaacccca gacacctgca tgttctgatt gggacctcag tggtcaaaat ccctttcacc     1320

atcctcctct tctttctcct tcatcgctgg tgctccaaca aaaaaaatgc tgctgtaatg     1380

gaccaagagc ctgcagggaa cagaacagtg aacagcgagg attctgatga acaagaccat     1440

caggaggtgt catacgcata a                                               1461


<210>  38
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806-KIR-CAR

<400>  38

Met Gly Gly Leu Glu Pro Cys Ser Arg Phe Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Val Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys Val Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
        115                 120                 125             


Asp Val Glu Glu Asn Pro Gly Pro Arg Met Ala Leu Pro Val Thr Ala 
    130                 135                 140                 


Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser 
145                 150                 155                 160 


Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
                165                 170                 175     


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            180                 185                 190         


Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        195                 200                 205             


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu 
    210                 215                 220                 


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
225                 230                 235                 240 


Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys 
                245                 250                 255     


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            260                 265                 270         


Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly 
        275                 280                 285             


Gly Gly Ser Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val 
    290                 295                 300                 


Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp Ile 
305                 310                 315                 320 


Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe Lys 
                325                 330                 335     


Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser Arg 
            340                 345                 350         


Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser 
        355                 360                 365             


Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln 
    370                 375                 380                 


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Pro Thr Glu Pro 
                405                 410                 415     


Ser Ser Lys Thr Gly Asn Pro Arg His Leu His Val Leu Ile Gly Thr 
            420                 425                 430         


Ser Val Val Lys Ile Pro Phe Thr Ile Leu Leu Phe Phe Leu Leu His 
        435                 440                 445             


Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu Pro 
    450                 455                 460                 


Ala Gly Asn Arg Thr Val Asn Ser Glu Asp Ser Asp Glu Gln Asp His 
465                 470                 475                 480 


Gln Glu Val Ser Tyr Ala 
                485     


<210>  39
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ABT-806 humanized 806 VH

<400>  39
caggttcagc tgcaagagtc tggccctggc ctggtcaagc ctagccaaac actgagcctg       60

acctgtaccg tgtccggcta cagcatcagc agcgacttcg cctggaactg gatcagacag      120

cctcctggca aaggactgga atggatgggc tacatcagct acagcggcaa caccagatac      180

cagcctagcc tgaagtcccg gatcaccatc agcagagaca ccagcaagaa ccagttcttc      240

ctgaagctga acagcgtgac agccgccgat accgccacct actattgtgt gacagctggc      300

agaggcttcc cctattgggg acagggaaca ctggtcaccg ttagctct                   348


<210>  40
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ABT-806 humanized 806 VH

<400>  40
gatatccaga tgacacagag ccccagcagc atgtccgtgt ccgtgggaga cagagtgacc       60

atcacctgtc acagcagcca ggacatcaac agcaacatcg gctggctgca gcagaagccc      120

ggcaagtctt ttaagggcct gatctaccac ggcaccaacc tggatgatgg cgtgcccagc      180

agattttctg gcagcggctc tggcaccgac tacaccctga ccatatctag cctgcagcct      240

gaggacttcg ccacctatta ctgcgtgcag tacgcccagt ttccttggac ctttggaggc      300

ggcacaaagc tggaaatcaa gcgg                                             324


<210>  41
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ABT-806 humanized 806 scFv

<400>  41
caggttcagc tgcaagagtc tggccctggc ctggtcaagc ctagccaaac actgagcctg       60

acctgtaccg tgtccggcta cagcatcagc agcgacttcg cctggaactg gatcagacag      120

cctcctggca aaggactgga atggatgggc tacatcagct acagcggcaa caccagatac      180

cagcctagcc tgaagtcccg gatcaccatc agcagagaca ccagcaagaa ccagttcttc      240

ctgaagctga acagcgtgac agccgccgat accgccacct actattgtgt gacagctggc      300

agaggcttcc cctattgggg acagggaaca ctggtcaccg ttagctctga tatccagatg      360

acacagagcc ccagcagcat gtccgtgtcc gtgggagaca gagtgaccat cacctgtcac      420

agcagccagg acatcaacag caacatcggc tggctgcagc agaagcccgg caagtctttt      480

aagggcctga tctaccacgg caccaacctg gatgatggcg tgcccagcag attttctggc      540

agcggctctg gcaccgacta caccctgacc atatctagcc tgcagcctga ggacttcgcc      600

acctattact gcgtgcagta cgcccagttt ccttggacct ttggaggcgg cacaaagctg      660

gaaatcaagc gg                                                          672


<210>  42
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABT-806 humanized 806 VH

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Gln Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  43
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABT-806 humanized 806 VL

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  44
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABT-806 humanized 806 scFv

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Gln Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser 
        115                 120                 125             


Val Ser Val Gly Asp Arg Val Thr Ile Thr Cys His Ser Ser Gln Asp 
    130                 135                 140                 


Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe 
145                 150                 155                 160 


Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Gly Val Pro Ser 
                165                 170                 175     


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
            180                 185                 190         


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Tyr Ala 
        195                 200                 205             


Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
    210                 215                 220                 


<210>  45
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 hinge

<400>  45
accactaccc cagcaccgag gccacccacc ccggctccta ccatcgcctc ccagcctctg       60

tccctgcgtc cggaggcatg tagacccgca gctggtgggg ccgtgcatac ccggggtctt      120

gacttcgcct gcgat                                                       135


<210>  46
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  46
atctacattt gggcccctct ggctggtact tgcggggtcc tgctgctttc actcgtgatc       60

actctttact gt                                                           72


<210>  47
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  41BB intracellular domain

<400>  47
aagcgcggtc ggaagaagct gctgtacatc tttaagcaac ccttcatgag gcctgtgcag       60

actactcaag aggaggacgg ctgttcatgc cggttcccag aggaggagga aggcggctgc      120

gaactg                                                                 126


<210>  48
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta

<400>  48
cgcgtgaaat tcagccgcag cgcagatgct ccagcctaca agcaggggca gaaccagctc       60

tacaacgaac tcaatcttgg tcggagagag gagtacgacg tgctggacaa gcggagagga      120

cgggacccag aaatgggcgg gaagccgcgc agaaagaatc cccaagaggg cctgtacaac      180

gagctccaaa aggataagat ggcagaagcc tatagcgaga ttggtatgaa aggggaacgc      240

agaagaggca aaggccacga cggactgtac cagggactca gcaccgccac caaggacacc      300

tatgacgctc ttcacatgca ggccctgccg cctcgg                                336


<210>  49
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 signal recognition peptide

<400>  49
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  50
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DAP12

<400>  50
atggggggac ttgaaccctg cagcaggttc ctgctcctgc ctctcctgct ggctgtaagt       60

ggtctccgtc ctgtccaggt ccaggcccag agcgattgca gttgctctac ggtgagcccg      120

ggcgtgctgg cagggatcgt gatgggagac ctggtgctga cagtgctcat tgccctggcc      180

gtgtacttcc tgggccggct ggtccctcgg gggcgagggg ctgcggaggc agcgacccgg      240

aaacagcgta tcactgagac cgagtcgcct tatcaggagc tccagggtca gaggtcggat      300

gtctacagcg acctcaacac acagaggccg tattacaaa                             339


<210>  51
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  51
gtcgagggcg gcggagaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat       60

cccggcccta gg                                                           72


<210>  52
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker and KIRS2

<400>  52
ggtggcggag gttctggagg tgggggttcc tcacccactg aaccaagctc caaaaccggt       60

aaccccagac acctgcatgt tctgattggg acctcagtgg tcaaaatccc tttcaccatc      120

ctcctcttct ttctccttca tcgctggtgc tccaacaaaa aaaatgctgc tgtaatggac      180

caagagcctg cagggaacag aacagtgaac agcgaggatt ctgatgaaca agaccatcag      240

gaggtgtcat acgcataa                                                    258


<210>  53
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pASP79 C225 BiTE

<400>  53

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser 
            20                  25                  30          


Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro 
    50                  55                  60                  


Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      


Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn 
            100                 105                 110         


Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu 
145                 150                 155                 160 


Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val 
                165                 170                 175     


His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val 
            180                 185                 190         


Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg 
        195                 200                 205             


Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe Lys Met 
    210                 215                 220                 


Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Ala 
225                 230                 235                 240 


Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln 
            260                 265                 270         


Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
        275                 280                 285             


Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys 
    290                 295                 300                 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
305                 310                 315                 320 


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
                325                 330                 335     


Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
            340                 345                 350         


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
        355                 360                 365             


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
    370                 375                 380                 


Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
                405                 410                 415     


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
            420                 425                 430         


Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
        435                 440                 445             


Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe 
    450                 455                 460                 


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
465                 470                 475                 480 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
                485                 490                 495     


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 


<210>  54
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pASP83 806 BiTE

<400>  54

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser 
            20                  25                  30          


Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp 
        35                  40                  45              


Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe 
    50                  55                  60                  


Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala 
            100                 105                 110         


Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Phe 
                165                 170                 175     


Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met 
            180                 185                 190         


Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu Lys 
        195                 200                 205             


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
    210                 215                 220                 


Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys Val 
225                 230                 235                 240 


Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ala Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly 
            260                 265                 270         


Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr 
        275                 280                 285             


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg 
    290                 295                 300                 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
305                 310                 315                 320 


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr 
                325                 330                 335     


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
            340                 345                 350         


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
        355                 360                 365             


Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val 
    370                 375                 380                 


Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val 
385                 390                 395                 400 


Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
                405                 410                 415     


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
            420                 425                 430         


Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile 
        435                 440                 445             


Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly 
    450                 455                 460                 


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala 
465                 470                 475                 480 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu 
                485                 490                 495     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505         


<210>  55
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu07 CAR VLVH

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Thr Ala 
        35                  40                  45              


Ser Leu Ser Val Ser Ser Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


His Gln Tyr His Arg Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr 
                165                 170                 175     


Lys Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Gly Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala 
        195                 200                 205             


Leu Met Ser Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ser Leu 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Asp His Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  56
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08 CAR VLVH

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 
        35                  40                  45              


Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser Thr Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe 
                85                  90                  95      


Ile Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg 
                165                 170                 175     


Asn Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp 
            180                 185                 190         


Val Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
    210                 215                 220                 


Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  57
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 VH

<400>  57
gaagtacagc tggttgagag tggcgggggt ctcgtacagc ccggcgggtc tcttaggctc       60

tcctgtgctg cttctggttt ctccttgact aaatacgggg tacattgggt tcgccaggcc      120

cctggcaaag gtcttgaatg ggtgggcgtc aagtgggctg gcggaagcac tgattataat      180

tccgcattga tgtcccgatt cactatttct aaggataatg ccaagaacag tctctatttg      240

caaatgaact ccctgagagc ggaggatact gccgtttact actgtgcacg ggatcaccga      300

gacgctatgg attactgggg tcagggtacc ctggtgaccg taagctcc                   348


<210>  58
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 HCDR1

<400>  58
actaaatacg gggtacat                                                     18


<210>  59
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 HCDR2

<400>  59
ggcgtcaagt gggctggcgg aagcactgat tataattccg cattgatgtc c                51


<210>  60
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 HCDR3

<400>  60
gatcaccgag acgctatgga ttac                                              24


<210>  61
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 VL

<400>  61
gacatacaaa tgacacagtc cccctcatcc ttgtctgctt ccgtaggaga ccgggttacc       60

atcacgtgca ccgcttcttt gtccgtttca agtacctacc tccactggta ccagcaaaaa      120

cccggcagca gccccaagtt gtggatttac tcaacttcta acttggcctc aggggtaccg      180

tcaagattta gcggatctgg cagtggcacg agttatactt tgacgatatc aagccttcaa      240

ccggaggatt tcgccaccta ttactgtcat cagtatcatc gaagcccctt gacctttggg      300

ggagggacaa aagtggaaat aaaa                                             324


<210>  62
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 LCDR1

<400>  62
accgcttctt tgtccgtttc aagtacctac ctccac                                 36


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 LCDR2

<400>  63
tcaacttcta acttggcctc a                                                 21


<210>  64
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 LCDR3

<400>  64
catcagtatc atcgaagccc cttgacc                                           27


<210>  65
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 CAR VHVL

<400>  65
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg aagtacagct ggttgagagt ggcgggggtc tcgtacagcc cggcgggtct      120

cttaggctct cctgtgctgc ttctggtttc tccttgacta aatacggggt acattgggtt      180

cgccaggccc ctggcaaagg tcttgaatgg gtgggcgtca agtgggctgg cggaagcact      240

gattataatt ccgcattgat gtcccgattc actatttcta aggataatgc caagaacagt      300

ctctatttgc aaatgaactc cctgagagcg gaggatactg ccgtttacta ctgtgcacgg      360

gatcaccgag acgctatgga ttactggggt cagggtaccc tggtgaccgt aagctccggg      420

ggaggtggaa gtggtggcgg tggatctggt ggcggcgggt cagacataca aatgacacag      480

tccccctcat ccttgtctgc ttccgtagga gaccgggtta ccatcacgtg caccgcttct      540

ttgtccgttt caagtaccta cctccactgg taccagcaaa aacccggcag cagccccaag      600

ttgtggattt actcaacttc taacttggcc tcaggggtac cgtcaagatt tagcggatct      660

ggcagtggca cgagttatac tttgacgata tcaagccttc aaccggagga tttcgccacc      720

tattactgtc atcagtatca tcgaagcccc ttgacctttg ggggagggac aaaagtggaa      780

ataaaatccg gaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210>  66
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 CAR VLVH

<400>  66
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acatacaaat gacacagtcc ccctcatcct tgtctgcttc cgtaggagac      120

cgggttacca tcacgtgcac cgcttctttg tccgtttcaa gtacctacct ccactggtac      180

cagcaaaaac ccggcagcag ccccaagttg tggatttact caacttctaa cttggcctca      240

ggggtaccgt caagatttag cggatctggc agtggcacga gttatacttt gacgatatca      300

agccttcaac cggaggattt cgccacctat tactgtcatc agtatcatcg aagccccttg      360

acctttgggg gagggacaaa agtggaaata aaagggggag gtggaagtgg tggcggtgga      420

tctggtggcg gcgggtcaga agtacagctg gttgagagtg gcgggggtct cgtacagccc      480

ggcgggtctc ttaggctctc ctgtgctgct tctggtttct ccttgactaa atacggggta      540

cattgggttc gccaggcccc tggcaaaggt cttgaatggg tgggcgtcaa gtgggctggc      600

ggaagcactg attataattc cgcattgatg tcccgattca ctatttctaa ggataatgcc      660

aagaacagtc tctatttgca aatgaactcc ctgagagcgg aggatactgc cgtttactac      720

tgtgcacggg atcaccgaga cgctatggat tactggggtc agggtaccct ggtgaccgta      780

agctcctccg gaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210>  67
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 VH

<400>  67
gaggttcagt tggtagagtc aggcggtggt ctggtgcagc caggtgggtc cctgcgcctc       60

agctgtgcag cttccggctt tactttctca aggaatggta tgtcctgggt acggcaaacg      120

ccggacaaac gccttgagtg ggtagctacc gtatcctctg ggggctctta catatactat      180

gcagactctg tgaaaggaag atttacaatt tcacgcgaca atgcaaaaaa tagtttgtac      240

ctccaaatgt ctagtcttag ggccgaggat actgccgtct actactgtgc acgccaggga      300

acgacggctc ttgctacccg atttttcgac gtttggggcc aaggaacgtt ggtgacagtt      360

agcagt                                                                 366


<210>  68
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 HCDR1

<400>  68
tcaaggaatg gtatgtcc                                                     18


<210>  69
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 HCDR2

<400>  69
accgtatcct ctgggggctc ttacatatac tatgcagact ctgtgaaagg a                51


<210>  70
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 HCDR3

<400>  70
cagggaacga cggctcttgc tacccgattt ttcgacgtt                              39


<210>  71
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 VL

<400>  71
gacatccaaa tgactcagag cccctctagc ctcagtgcaa gcgtcggaga ccgggtgacc       60

atcacctgta aagcgtccca ggatgttgga acggcagtag cttggtatca acaaatccca      120

gggaaggctc caaagctcct tatatactct gctagttaca ggtccaccgg ggtgcccgac      180

cgattctctg gctccgggag cggcactgac ttttcattca tcattagtag tcttcaacct      240

gaggactttg ccacctatta ttgccagcac cactactctg cgccgtggac tttcggagga      300

ggcacgaagg ttgaaattaa a                                                321


<210>  72
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 LCDR1

<400>  72
aaagcgtccc aggatgttgg aacggcagta gct                                    33


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 LCDR2

<400>  73
tctgctagtt acaggtccac c                                                 21


<210>  74
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 LCDR3

<400>  74
cagcaccact actctgcgcc gtggact                                           27


<210>  75
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 CAR VHVL

<400>  75
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg aggttcagtt ggtagagtca ggcggtggtc tggtgcagcc aggtgggtcc      120

ctgcgcctca gctgtgcagc ttccggcttt actttctcaa ggaatggtat gtcctgggta      180

cggcaaacgc cggacaaacg ccttgagtgg gtagctaccg tatcctctgg gggctcttac      240

atatactatg cagactctgt gaaaggaaga tttacaattt cacgcgacaa tgcaaaaaat      300

agtttgtacc tccaaatgtc tagtcttagg gccgaggata ctgccgtcta ctactgtgca      360

cgccagggaa cgacggctct tgctacccga tttttcgacg tttggggcca aggaacgttg      420

gtgacagtta gcagtggtgg aggtgggtct ggcggaggtg gaagtggtgg aggcgggtcc      480

gacatccaaa tgactcagag cccctctagc ctcagtgcaa gcgtcggaga ccgggtgacc      540

atcacctgta aagcgtccca ggatgttgga acggcagtag cttggtatca acaaatccca      600

gggaaggctc caaagctcct tatatactct gctagttaca ggtccaccgg ggtgcccgac      660

cgattctctg gctccgggag cggcactgac ttttcattca tcattagtag tcttcaacct      720

gaggactttg ccacctatta ttgccagcac cactactctg cgccgtggac tttcggagga      780

ggcacgaagg ttgaaattaa atccggaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1476


<210>  76
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 CAR VLVH

<400>  76
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acatccaaat gactcagagc ccctctagcc tcagtgcaag cgtcggagac      120

cgggtgacca tcacctgtaa agcgtcccag gatgttggaa cggcagtagc ttggtatcaa      180

caaatcccag ggaaggctcc aaagctcctt atatactctg ctagttacag gtccaccggg      240

gtgcccgacc gattctctgg ctccgggagc ggcactgact tttcattcat cattagtagt      300

cttcaacctg aggactttgc cacctattat tgccagcacc actactctgc gccgtggact      360

ttcggaggag gcacgaaggt tgaaattaaa ggtggaggtg ggtctggcgg aggtggaagt      420

ggtggaggcg ggtccgaggt tcagttggta gagtcaggcg gtggtctggt gcagccaggt      480

gggtccctgc gcctcagctg tgcagcttcc ggctttactt tctcaaggaa tggtatgtcc      540

tgggtacggc aaacgccgga caaacgcctt gagtgggtag ctaccgtatc ctctgggggc      600

tcttacatat actatgcaga ctctgtgaaa ggaagattta caatttcacg cgacaatgca      660

aaaaatagtt tgtacctcca aatgtctagt cttagggccg aggatactgc cgtctactac      720

tgtgcacgcc agggaacgac ggctcttgct acccgatttt tcgacgtttg gggccaagga      780

acgttggtga cagttagcag ttccggaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1476


<210>  77
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 VH

<400>  77

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Asn Cys Thr Val Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Asn Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asp Asp Ser Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  78
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 VH

<400>  78
caagtgcaat tgaaggagag cgggccaggt ttggtcgccc cctcccaatc attgtccatt       60

aactgtaccg tctctggttt tagtttgacc aaatatggag ttcactggat cagacaatca      120

cctggcaaag gactcgagtg gctgggggtc aagtgggcag gaggctctac cgattacaat      180

tctgccctga tgagccgact tactataagc aaagacaata ataagagcca agtttttctg      240

aaaatgaaca gcctgcagag cgatgactca gccatgtact actgcgccag agaccaccgc      300

gacgctatgg attattgggg gcagggcacc agtgtcacgg tatcaagc                   348


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 HCDR1

<400>  79

Thr Lys Tyr Gly Val His 
1               5       


<210>  80
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 HCDR1

<400>  80
accaaatatg gagttcac                                                     18


<210>  81
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 HCDR2

<400>  81
gtcaagtggg caggaggctc taccgattac aattctgccc tgatgagc                    48


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 HCDR3

<400>  82

Asp His Arg Asp Ala Met Asp Tyr 
1               5               


<210>  83
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 HCDR3

<400>  83
gaccaccgcg acgctatgga ttat                                              24


<210>  84
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 VL

<400>  84

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Leu Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu His Trp Tyr His Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  85
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 VL

<400>  85
caggtcgtgc ttactcagag tcccgctata atgagtgcca gtccaggtga gcgggtgaca       60

atgacgtgta cggctagtct ttctgtatcc agtacttatc tgcactggta tcatcagaaa      120

ccgggtagct caccgaagct gtggatctac tccacctcca atttggcatc tggagttcca      180

gctaggttca gcggtagcgg cagcgggaca tcctactccc tgacaatttc aagcatggag      240

gcggaagacg cggccactta ctattgtcat caataccacc ggtctccact cacctttggg      300

agtggcacta aacttgagct taag                                             324


<210>  86
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 LCDR1

<400>  86

Thr Ala Ser Leu Ser Val Ser Ser Thr Tyr Leu His 
1               5                   10          


<210>  87
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 LCDR1

<400>  87
acggctagtc tttctgtatc cagtacttat ctgcac                                 36


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 LCDR2

<400>  88

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 LCDR2

<400>  89
tccacctcca atttggcatc t                                                 21


<210>  90
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 LCDR3

<400>  90

His Gln Tyr His Arg Ser Pro Leu Thr 
1               5                   


<210>  91
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 LCDR3

<400>  91
catcaatacc accggtctcc actcacc                                           27


<210>  92
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 CAR VHVL

<400>  92

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
            20                  25                  30          


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Asn Cys Thr Val Ser 
        35                  40                  45              


Gly Phe Ser Leu Thr Lys Tyr Gly Val His Trp Ile Arg Gln Ser Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Leu Gly Val Lys Trp Ala Gly Gly Ser Thr 
65                  70                  75                  80  


Asp Tyr Asn Ser Ala Leu Met Ser Arg Leu Thr Ile Ser Lys Asp Asn 
                85                  90                  95      


Asn Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Ser Asp Asp 
            100                 105                 110         


Ser Ala Met Tyr Tyr Cys Ala Arg Asp His Arg Asp Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Arg Val Thr Met Thr 
                165                 170                 175     


Cys Thr Ala Ser Leu Ser Val Ser Ser Thr Tyr Leu His Trp Tyr His 
            180                 185                 190         


Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn 
        195                 200                 205             


Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys His Gln Tyr His Arg Ser Pro Leu Thr Phe Gly Ser Gly 
                245                 250                 255     


Thr Lys Leu Glu Leu Lys Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  93
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 CAR VHVL

<400>  93
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccc aagtgcaatt gaaggagagc gggccaggtt tggtcgcccc ctcccaatca      120

ttgtccatta actgtaccgt ctctggtttt agtttgacca aatatggagt tcactggatc      180

agacaatcac ctggcaaagg actcgagtgg ctgggggtca agtgggcagg aggctctacc      240

gattacaatt ctgccctgat gagccgactt actataagca aagacaataa taagagccaa      300

gtttttctga aaatgaacag cctgcagagc gatgactcag ccatgtacta ctgcgccaga      360

gaccaccgcg acgctatgga ttattggggg cagggcacca gtgtcacggt atcaagcggt      420

ggtggggggt caggcggagg cggtagtgga gggggaggca gtcaggtcgt gcttactcag      480

agtcccgcta taatgagtgc cagtccaggt gagcgggtga caatgacgtg tacggctagt      540

ctttctgtat ccagtactta tctgcactgg tatcatcaga aaccgggtag ctcaccgaag      600

ctgtggatct actccacctc caatttggca tctggagttc cagctaggtt cagcggtagc      660

ggcagcggga catcctactc cctgacaatt tcaagcatgg aggcggaaga cgcggccact      720

tactattgtc atcaatacca ccggtctcca ctcacctttg ggagtggcac taaacttgag      780

cttaagtccg gaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210>  94
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 CAR VLVH

<400>  94

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Ile Met Ser Ala Ser Pro Gly Glu Arg Val Thr Met Thr Cys Thr Ala 
        35                  40                  45              


Ser Leu Ser Val Ser Ser Thr Tyr Leu His Trp Tyr His Gln Lys Pro 
    50                  55                  60                  


Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
                85                  90                  95      


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


His Gln Tyr His Arg Ser Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Ile Asn Cys Thr Val Ser Gly Phe Ser Leu Thr 
                165                 170                 175     


Lys Tyr Gly Val His Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Leu Gly Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala 
        195                 200                 205             


Leu Met Ser Arg Leu Thr Ile Ser Lys Asp Asn Asn Lys Ser Gln Val 
    210                 215                 220                 


Phe Leu Lys Met Asn Ser Leu Gln Ser Asp Asp Ser Ala Met Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Asp His Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  95
<211>  1458
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 CAR VLVH

<400>  95
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccc aggtcgtgct tactcagagt cccgctataa tgagtgccag tccaggtgag      120

cgggtgacaa tgacgtgtac ggctagtctt tctgtatcca gtacttatct gcactggtat      180

catcagaaac cgggtagctc accgaagctg tggatctact ccacctccaa tttggcatct      240

ggagttccag ctaggttcag cggtagcggc agcgggacat cctactccct gacaatttca      300

agcatggagg cggaagacgc ggccacttac tattgtcatc aataccaccg gtctccactc      360

acctttggga gtggcactaa acttgagctt aagggtggtg gggggtcagg cggaggcggt      420

agtggagggg gaggcagtca agtgcaattg aaggagagcg ggccaggttt ggtcgccccc      480

tcccaatcat tgtccattaa ctgtaccgtc tctggtttta gtttgaccaa atatggagtt      540

cactggatca gacaatcacc tggcaaagga ctcgagtggc tgggggtcaa gtgggcagga      600

ggctctaccg attacaattc tgccctgatg agccgactta ctataagcaa agacaataat      660

aagagccaag tttttctgaa aatgaacagc ctgcagagcg atgactcagc catgtactac      720

tgcgccagag accaccgcga cgctatggat tattgggggc agggcaccag tgtcacggta      780

tcatccggaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgc                                                   1458


<210>  96
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 VH

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gln Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  97
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 VH

<400>  97
gaggtgcaac tcgttgaatc aggtggggac ttggtgcgcc caggaggtag cctgcaattg       60

agctgtgctg ctagcgggtt cactttttca cggaacggta tgtcttgggt acggcagacc      120

cctgacagaa gactggagtg ggttgcaact gtcagttctg gtggctccta tatttactac      180

gcagacagcg taaaagggag atttaccata agccgggata atgcccgaaa taccctctac      240

ctccagatgt cctccttgaa aagtgaggac acggctatgt actattgcgc cagacaagga      300

accactgcac ttgcaacgag attttttgac gtttggggag ccgggaccac cgtaactgtg      360

agtagc                                                                 366


<210>  98
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 HCDR1

<400>  98

Ser Arg Asn Gly Met Ser 
1               5       


<210>  99
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 HCDR1

<400>  99
tcacggaacg gtatgtct                                                     18


<210>  100
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 HCDR2

<400>  100

Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  101
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 HCDR1

<400>  101
actgtcagtt ctggtggctc ctatatttac tacgcagaca gcgtaaaagg g                51


<210>  102
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 HCDR3

<400>  102
caaggaacca ctgcacttgc aacgagattt tttgac                                 36


<210>  103
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 VL

<400>  103

Asp Ile Val Met Thr Gln Ser His Lys Phe Ile Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Ile Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Thr Leu Asp Ile Lys 
            100                 105         


<210>  104
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 VL

<400>  104
gacattgtta tgacgcagtc tcataagttc atctctacat ccgtcgggga ccgggtgagc       60

attacctgta aagcctccca ggatgtaggt acagctgttg catggtacca gcaaataccg      120

ggtcagtctc cgaaactcct gatttacagc gcctcctatc gaagcaccgg gatacctgat      180

agatttactg gatcaggttc agggacagac ttcagtttta tcatcagctc tgtgcaagca      240

gaggatctcg cgctttacta ctgtcagcat cattacagcg ctccgtggac gttcggcggc      300

gggacaaccc tggatatcaa a                                                321


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 LCDR1

<400>  105

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  106
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 LCDR1

<400>  106
aaagcctccc aggatgtagg tacagctgtt gca                                    33


<210>  107
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 LCDR2

<400>  107

Ser Ala Ser Tyr Arg Ser Thr 
1               5           


<210>  108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 LCDR2

<400>  108
agcgcctcct atcgaagcac c                                                 21


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 LCDR3

<400>  109

Gln His His Tyr Ser Ala Pro Trp Thr 
1               5                   


<210>  110
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 LCDR3

<400>  110
cagcatcatt acagcgctcc gtggacg                                           27


<210>  111
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 CAR VHVL

<400>  111

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Asp Leu Val Arg Pro Gly Gly Ser Leu Gln Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg Gln Thr Pro 
    50                  55                  60                  


Asp Arg Arg Leu Glu Trp Val Ala Thr Val Ser Ser Gly Gly Ser Tyr 
65                  70                  75                  80  


Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu 
            100                 105                 110         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Gly Thr Thr Ala Leu Ala 
        115                 120                 125             


Thr Arg Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Val Met Thr Gln Ser His Lys Phe Ile Ser Thr Ser Val Gly 
                165                 170                 175     


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            180                 185                 190         


Val Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Ile Pro Asp Arg Phe Thr Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser Ser Val Gln Ala 
225                 230                 235                 240 


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Thr Leu Asp Ile Lys Ser Gly Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  112
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 CAR VHVL

<400>  112
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg aggtgcaact cgttgaatca ggtggggact tggtgcgccc aggaggtagc      120

ctgcaattga gctgtgctgc tagcgggttc actttttcac ggaacggtat gtcttgggta      180

cggcagaccc ctgacagaag actggagtgg gttgcaactg tcagttctgg tggctcctat      240

atttactacg cagacagcgt aaaagggaga tttaccataa gccgggataa tgcccgaaat      300

accctctacc tccagatgtc ctccttgaaa agtgaggaca cggctatgta ctattgcgcc      360

agacaaggaa ccactgcact tgcaacgaga ttttttgacg tttggggagc cgggaccacc      420

gtaactgtga gtagcggggg cggtggtagc ggtggaggtg ggtcaggggg tggtggttca      480

gacattgtta tgacgcagtc tcataagttc atctctacat ccgtcgggga ccgggtgagc      540

attacctgta aagcctccca ggatgtaggt acagctgttg catggtacca gcaaataccg      600

ggtcagtctc cgaaactcct gatttacagc gcctcctatc gaagcaccgg gatacctgat      660

agatttactg gatcaggttc agggacagac ttcagtttta tcatcagctc tgtgcaagca      720

gaggatctcg cgctttacta ctgtcagcat cattacagcg ctccgtggac gttcggcggc      780

gggacaaccc tggatatcaa atccggaacc acgacgccag cgccgcgacc accaacaccg      840

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      900

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      960

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     1020

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1080

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1140

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc     1200

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc     1260

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1320

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1380

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1440

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1476


<210>  113
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 CAR VLVH

<400>  113

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Val Met Thr Gln Ser His Lys 
            20                  25                  30          


Phe Ile Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala 
        35                  40                  45              


Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser Thr Gly 
65                  70                  75                  80  


Ile Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe 
                85                  90                  95      


Ile Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Gln 
            100                 105                 110         


His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Thr Leu Asp 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Arg Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Gln Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg 
                165                 170                 175     


Asn Gly Met Ser Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Trp 
            180                 185                 190         


Val Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu 
    210                 215                 220                 


Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val 
                245                 250                 255     


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  114
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 CAR VLVH

<400>  114
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg acattgttat gacgcagtct cataagttca tctctacatc cgtcggggac      120

cgggtgagca ttacctgtaa agcctcccag gatgtaggta cagctgttgc atggtaccag      180

caaataccgg gtcagtctcc gaaactcctg atttacagcg cctcctatcg aagcaccggg      240

atacctgata gatttactgg atcaggttca gggacagact tcagttttat catcagctct      300

gtgcaagcag aggatctcgc gctttactac tgtcagcatc attacagcgc tccgtggacg      360

ttcggcggcg ggacaaccct ggatatcaaa gggggcggtg gtagcggtgg aggtgggtca      420

gggggtggtg gttcagaggt gcaactcgtt gaatcaggtg gggacttggt gcgcccagga      480

ggtagcctgc aattgagctg tgctgctagc gggttcactt tttcacggaa cggtatgtct      540

tgggtacggc agacccctga cagaagactg gagtgggttg caactgtcag ttctggtggc      600

tcctatattt actacgcaga cagcgtaaaa gggagattta ccataagccg ggataatgcc      660

cgaaataccc tctacctcca gatgtcctcc ttgaaaagtg aggacacggc tatgtactat      720

tgcgccagac aaggaaccac tgcacttgca acgagatttt ttgacgtttg gggagccggg      780

accaccgtaa ctgtgagttc cggaaccacg acgccagcgc cgcgaccacc aacaccggcg      840

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg      900

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgc                                  1473


<210>  115
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secreting signaling

<400>  115

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  116
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Secreting signaling

<400>  116
atggaaacag atacattgtt gttgtgggta ctcctgctgt gggtccctgg gagcaccggt       60


<210>  117
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C225 scFv

<400>  117

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Gln 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg 
145                 150                 155                 160 


Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly 
                165                 170                 175     


Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr 
    210                 215                 220                 


Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ala 
    


<210>  118
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C225 scFv

<400>  118
gacatacttc tcacacaatc tcccgtgatt ctcagcgtat caccaggtga aagggtgagc       60

ttctcttgtc gcgccagcca atccatcggg actaatatcc actggtatca gcagcgaacg      120

aatgggagcc cacggcttct tattaagtac gccagtgagt caatttcagg tatcccgagc      180

cgattcagtg gaagtgggag tgggactgac ttcactttga gcatcaattc cgtcgagtct      240

gaggacatag ccgattatta ttgccaacag aataacaact ggccgactac ttttggggcg      300

ggtacaaaac tcgaactcaa gggtgggggt ggatctggcg gaggtgggtc cgggggggga      360

ggctctcaag tccagctcaa acaaagcgga ccgggattgg tgcaaccctc tcaatctctc      420

tccataacgt gtacggtgtc cggtttttct ctcaccaact acggtgtcca ttgggtacgg      480

caatctccag gcaagggcct ggaatggctt ggtgttatct ggagcggcgg gaatactgac      540

tataataccc cattcacgag caggctcagc attaacaaag acaattcaaa gtcacaagta      600

ttcttcaaga tgaactcact tcagtccaat gatactgcaa tatactactg cgcgagagcc      660

cttacatact atgactatga gttcgcttac tggggtcaag gtacgttggt caccgtctcc      720

gcc                                                                    723


<210>  119
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 BiTE scFv

<400>  119

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln 
        115                 120                 125             


Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr 
    130                 135                 140                 


Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Phe Ala Trp Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Ser 
                165                 170                 175     


Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser 
            180                 185                 190         


Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser 
        195                 200                 205             


Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys Val Thr Ala Gly Arg 
    210                 215                 220                 


Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
225                 230                 235                 


<210>  120
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806 BiTE scFv

<400>  120
gatattctga tgactcaatc tccgtcttct atgagcgtga gcttgggtga caccgtcagc       60

atcacctgtc attccagcca ggatataaac tcaaatatcg gctggctcca gcaacgccca      120

ggcaagtcat tcaaggggct tatttatcat ggcaccaatc ttgacgatga agtcccatca      180

cgcttcagcg gatcaggctc aggtgcggac tattccttga ctataagttc cctcgaatct      240

gaggatttcg ccgactatta ttgcgtacaa tacgcccagt ttccctggac cttcggaggc      300

ggcaccaaat tggagataaa aaggggtgga ggaggatcag gcgggggtgg aagcggcgga      360

ggaggcagcg acgtacaact gcaagaatcc gggccgagtt tggtcaagcc ctctcaatct      420

ctttctctca cttgcacggt caccggatac tccataacca gcgattttgc gtggaattgg      480

attcgacaat ttccagggaa taaattggaa tggatgggat atatcagtta ttctggtaat      540

accagataca acccgtcatt gaaaagtcgc atctctataa cacgagacac ttcaaagaat      600

cagttcttcc ttcagctcaa ttctgtaacc atcgaagata ctgctactta ttactgtgta      660

acggcgggtc gaggattccc ctactggggc cagggtacac tggttactgt ttccgcc         717


<210>  121
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OKT3 scFv

<400>  121

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
                165                 170                 175     


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
            180                 185                 190         


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  122
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OKT3 scFv

<400>  122
gatattaagc tccagcaatc aggggcagaa ttggcccgcc ccggtgcaag cgtgaaaatg       60

tcctgcaaga ctagcggata cacttttacc agatacacga tgcactgggt taaacagcga      120

ccggggcaag gcttggagtg gatcggatat attaacccaa gtcgcggcta cacgaattac      180

aaccagaaat tcaaagacaa ggcaacactg accacagata aatcatcatc taccgcgtat      240

atgcaactga gttcacttac tagcgaggat tctgcggtat attactgtgc gcggtactac      300

gacgaccatt actgtctgga ctattggggt caaggcacca cccttactgt gagttcagta      360

gaaggaggca gtgggggctc tggagggagc ggtggctcag gaggggtaga cgacatccaa      420

ctgacgcaat ctccggctat aatgtcagcg tctccggggg aaaaagtaac gatgacttgt      480

cgcgcgtcca gcagcgtctc ttatatgaac tggtatcaac agaagagtgg gacgagtcct      540

aagcgatgga tatatgatac aagcaaagtt gcgagcggag tcccgtatcg cttctctgga      600

agtggcagcg gaacctctta ctccctcacg atcagcagca tggaggcgga ggacgcagcc      660

acctactact gtcagcagtg gtcttccaac cctctgacat tcggagccgg tacaaaactt      720

gaactgaaa                                                              729


<210>  123
<211>  1527
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C225 BiTE

<400>  123
atggaaacag atacattgtt gttgtgggta ctcctgctgt gggtccctgg gagcaccggt       60

gacatacttc tcacacaatc tcccgtgatt ctcagcgtat caccaggtga aagggtgagc      120

ttctcttgtc gcgccagcca atccatcggg actaatatcc actggtatca gcagcgaacg      180

aatgggagcc cacggcttct tattaagtac gccagtgagt caatttcagg tatcccgagc      240

cgattcagtg gaagtgggag tgggactgac ttcactttga gcatcaattc cgtcgagtct      300

gaggacatag ccgattatta ttgccaacag aataacaact ggccgactac ttttggggcg      360

ggtacaaaac tcgaactcaa gggtgggggt ggatctggcg gaggtgggtc cgggggggga      420

ggctctcaag tccagctcaa acaaagcgga ccgggattgg tgcaaccctc tcaatctctc      480

tccataacgt gtacggtgtc cggtttttct ctcaccaact acggtgtcca ttgggtacgg      540

caatctccag gcaagggcct ggaatggctt ggtgttatct ggagcggcgg gaatactgac      600

tataataccc cattcacgag caggctcagc attaacaaag acaattcaaa gtcacaagta      660

ttcttcaaga tgaactcact tcagtccaat gatactgcaa tatactactg cgcgagagcc      720

cttacatact atgactatga gttcgcttac tggggtcaag gtacgttggt caccgtctcc      780

gccggcggag gaggaagtga tattaagctc cagcaatcag gggcagaatt ggcccgcccc      840

ggtgcaagcg tgaaaatgtc ctgcaagact agcggataca cttttaccag atacacgatg      900

cactgggtta aacagcgacc ggggcaaggc ttggagtgga tcggatatat taacccaagt      960

cgcggctaca cgaattacaa ccagaaattc aaagacaagg caacactgac cacagataaa     1020

tcatcatcta ccgcgtatat gcaactgagt tcacttacta gcgaggattc tgcggtatat     1080

tactgtgcgc ggtactacga cgaccattac tgtctggact attggggtca aggcaccacc     1140

cttactgtga gttcagtaga aggaggcagt gggggctctg gagggagcgg tggctcagga     1200

ggggtagacg acatccaact gacgcaatct ccggctataa tgtcagcgtc tccgggggaa     1260

aaagtaacga tgacttgtcg cgcgtccagc agcgtctctt atatgaactg gtatcaacag     1320

aagagtggga cgagtcctaa gcgatggata tatgatacaa gcaaagttgc gagcggagtc     1380

ccgtatcgct tctctggaag tggcagcgga acctcttact ccctcacgat cagcagcatg     1440

gaggcggagg acgcagccac ctactactgt cagcagtggt cttccaaccc tctgacattc     1500

ggagccggta caaaacttga actgaaa                                         1527


<210>  124
<211>  1521
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806 BiTE

<400>  124
atggaaacag atacattgtt gttgtgggta ctcctgctgt gggtccctgg gagcaccggt       60

gatattctga tgactcaatc tccgtcttct atgagcgtga gcttgggtga caccgtcagc      120

atcacctgtc attccagcca ggatataaac tcaaatatcg gctggctcca gcaacgccca      180

ggcaagtcat tcaaggggct tatttatcat ggcaccaatc ttgacgatga agtcccatca      240

cgcttcagcg gatcaggctc aggtgcggac tattccttga ctataagttc cctcgaatct      300

gaggatttcg ccgactatta ttgcgtacaa tacgcccagt ttccctggac cttcggaggc      360

ggcaccaaat tggagataaa aaggggtgga ggaggatcag gcgggggtgg aagcggcgga      420

ggaggcagcg acgtacaact gcaagaatcc gggccgagtt tggtcaagcc ctctcaatct      480

ctttctctca cttgcacggt caccggatac tccataacca gcgattttgc gtggaattgg      540

attcgacaat ttccagggaa taaattggaa tggatgggat atatcagtta ttctggtaat      600

accagataca acccgtcatt gaaaagtcgc atctctataa cacgagacac ttcaaagaat      660

cagttcttcc ttcagctcaa ttctgtaacc atcgaagata ctgctactta ttactgtgta      720

acggcgggtc gaggattccc ctactggggc cagggtacac tggttactgt ttccgccgga      780

ggaggaggaa gtgatattaa gctccagcaa tcaggggcag aattggcccg ccccggtgca      840

agcgtgaaaa tgtcctgcaa gactagcgga tacactttta ccagatacac gatgcactgg      900

gttaaacagc gaccggggca aggcttggag tggatcggat atattaaccc aagtcgcggc      960

tacacgaatt acaaccagaa attcaaagac aaggcaacac tgaccacaga taaatcatca     1020

tctaccgcgt atatgcaact gagttcactt actagcgagg attctgcggt atattactgt     1080

gcgcggtact acgacgacca ttactgtctg gactattggg gtcaaggcac cacccttact     1140

gtgagttcag tagaaggagg cagtgggggc tctggaggga gcggtggctc aggaggggta     1200

gacgacatcc aactgacgca atctccggct ataatgtcag cgtctccggg ggaaaaagta     1260

acgatgactt gtcgcgcgtc cagcagcgtc tcttatatga actggtatca acagaagagt     1320

gggacgagtc ctaagcgatg gatatatgat acaagcaaag ttgcgagcgg agtcccgtat     1380

cgcttctctg gaagtggcag cggaacctct tactccctca cgatcagcag catggaggcg     1440

gaggacgcag ccacctacta ctgtcagcag tggtcttcca accctctgac attcggagcc     1500

ggtacaaaac ttgaactgaa a                                               1521


<210>  125
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 scFv VHVL

<400>  125

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Asn Cys Thr Val Ser Gly Phe Ser Leu Thr Lys Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Asn Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asp Asp Ser Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp His Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
    130                 135                 140                 


Ser Pro Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Leu Ser Val 
145                 150                 155                 160 


Ser Ser Thr Tyr Leu His Trp Tyr His Gln Lys Pro Gly Ser Ser Pro 
                165                 170                 175     


Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
        195                 200                 205             


Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His 
    210                 215                 220                 


Arg Ser Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
225                 230                 235                 


<210>  126
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 scFv VHVL

<400>  126
caagtgcaat tgaaggagag cgggccaggt ttggtcgccc cctcccaatc attgtccatt       60

aactgtaccg tctctggttt tagtttgacc aaatatggag ttcactggat cagacaatca      120

cctggcaaag gactcgagtg gctgggggtc aagtgggcag gaggctctac cgattacaat      180

tctgccctga tgagccgact tactataagc aaagacaata ataagagcca agtttttctg      240

aaaatgaaca gcctgcagag cgatgactca gccatgtact actgcgccag agaccaccgc      300

gacgctatgg attattgggg gcagggcacc agtgtcacgg tatcaagcgg tggtgggggg      360

tcaggcggag gcggtagtgg agggggaggc agtcaggtcg tgcttactca gagtcccgct      420

ataatgagtg ccagtccagg tgagcgggtg acaatgacgt gtacggctag tctttctgta      480

tccagtactt atctgcactg gtatcatcag aaaccgggta gctcaccgaa gctgtggatc      540

tactccacct ccaatttggc atctggagtt ccagctaggt tcagcggtag cggcagcggg      600

acatcctact ccctgacaat ttcaagcatg gaggcggaag acgcggccac ttactattgt      660

catcaatacc accggtctcc actcaccttt gggagtggca ctaaacttga gcttaag         717


<210>  127
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu07 scFv VLVH

<400>  127

Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Leu Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu His Trp Tyr His Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys 
        115                 120                 125             


Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Asn 
    130                 135                 140                 


Cys Thr Val Ser Gly Phe Ser Leu Thr Lys Tyr Gly Val His Trp Ile 
145                 150                 155                 160 


Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Lys Trp Ala 
                165                 170                 175     


Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met Ser Arg Leu Thr Ile 
            180                 185                 190         


Ser Lys Asp Asn Asn Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
        195                 200                 205             


Gln Ser Asp Asp Ser Ala Met Tyr Tyr Cys Ala Arg Asp His Arg Asp 
    210                 215                 220                 


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
225                 230                 235                 


<210>  128
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu07 scFv VLVH

<400>  128
caggtcgtgc ttactcagag tcccgctata atgagtgcca gtccaggtga gcgggtgaca       60

atgacgtgta cggctagtct ttctgtatcc agtacttatc tgcactggta tcatcagaaa      120

ccgggtagct caccgaagct gtggatctac tccacctcca atttggcatc tggagttcca      180

gctaggttca gcggtagcgg cagcgggaca tcctactccc tgacaatttc aagcatggag      240

gcggaagacg cggccactta ctattgtcat caataccacc ggtctccact cacctttggg      300

agtggcacta aacttgagct taagggtggt ggggggtcag gcggaggcgg tagtggaggg      360

ggaggcagtc aagtgcaatt gaaggagagc gggccaggtt tggtcgcccc ctcccaatca      420

ttgtccatta actgtaccgt ctctggtttt agtttgacca aatatggagt tcactggatc      480

agacaatcac ctggcaaagg actcgagtgg ctgggggtca agtgggcagg aggctctacc      540

gattacaatt ctgccctgat gagccgactt actataagca aagacaataa taagagccaa      600

gtttttctga aaatgaacag cctgcagagc gatgactcag ccatgtacta ctgcgccaga      660

gaccaccgcg acgctatgga ttattggggg cagggcacca gtgtcacggt atcaagc         717


<210>  129
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 scFv VHVL

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Gln Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


His Lys Phe Ile Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser 
            180                 185                 190         


Thr Gly Ile Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Ser Phe Ile Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr 
    210                 215                 220                 


Cys Gln His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Thr 
225                 230                 235                 240 


Leu Asp Ile Lys 
                


<210>  130
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 scFv VHVL

<400>  130
gaggtgcaac tcgttgaatc aggtggggac ttggtgcgcc caggaggtag cctgcaattg       60

agctgtgctg ctagcgggtt cactttttca cggaacggta tgtcttgggt acggcagacc      120

cctgacagaa gactggagtg ggttgcaact gtcagttctg gtggctccta tatttactac      180

gcagacagcg taaaagggag atttaccata agccgggata atgcccgaaa taccctctac      240

ctccagatgt cctccttgaa aagtgaggac acggctatgt actattgcgc cagacaagga      300

accactgcac ttgcaacgag attttttgac gtttggggag ccgggaccac cgtaactgtg      360

agtagcgggg gcggtggtag cggtggaggt gggtcagggg gtggtggttc agacattgtt      420

atgacgcagt ctcataagtt catctctaca tccgtcgggg accgggtgag cattacctgt      480

aaagcctccc aggatgtagg tacagctgtt gcatggtacc agcaaatacc gggtcagtct      540

ccgaaactcc tgatttacag cgcctcctat cgaagcaccg ggatacctga tagatttact      600

ggatcaggtt cagggacaga cttcagtttt atcatcagct ctgtgcaagc agaggatctc      660

gcgctttact actgtcagca tcattacagc gctccgtgga cgttcggcgg cgggacaacc      720

ctggatatca aa                                                          732


<210>  131
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mu08 scFv VLVH

<400>  131

Asp Ile Val Met Thr Gln Ser His Lys Phe Ile Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Ile Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Thr Leu Asp Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Asp Leu Val Arg Pro Gly Gly Ser Leu Gln Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Arg Arg Leu Glu Trp Val Ala Thr Val Ser Ser Gly 
                165                 170                 175     


Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Gly Thr Thr 
    210                 215                 220                 


Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  132
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mu08 scFv VLVH

<400>  132
gacattgtta tgacgcagtc tcataagttc atctctacat ccgtcgggga ccgggtgagc       60

attacctgta aagcctccca ggatgtaggt acagctgttg catggtacca gcaaataccg      120

ggtcagtctc cgaaactcct gatttacagc gcctcctatc gaagcaccgg gatacctgat      180

agatttactg gatcaggttc agggacagac ttcagtttta tcatcagctc tgtgcaagca      240

gaggatctcg cgctttacta ctgtcagcat cattacagcg ctccgtggac gttcggcggc      300

gggacaaccc tggatatcaa agggggcggt ggtagcggtg gaggtgggtc agggggtggt      360

ggttcagagg tgcaactcgt tgaatcaggt ggggacttgg tgcgcccagg aggtagcctg      420

caattgagct gtgctgctag cgggttcact ttttcacgga acggtatgtc ttgggtacgg      480

cagacccctg acagaagact ggagtgggtt gcaactgtca gttctggtgg ctcctatatt      540

tactacgcag acagcgtaaa agggagattt accataagcc gggataatgc ccgaaatacc      600

ctctacctcc agatgtcctc cttgaaaagt gaggacacgg ctatgtacta ttgcgccaga      660

caaggaacca ctgcacttgc aacgagattt tttgacgttt ggggagccgg gaccaccgta      720

actgtgagta gc                                                          732


<210>  133
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 scFv VLVH

<400>  133
gacatacaaa tgacacagtc cccctcatcc ttgtctgctt ccgtaggaga ccgggttacc       60

atcacgtgca ccgcttcttt gtccgtttca agtacctacc tccactggta ccagcaaaaa      120

cccggcagca gccccaagtt gtggatttac tcaacttcta acttggcctc aggggtaccg      180

tcaagattta gcggatctgg cagtggcacg agttatactt tgacgatatc aagccttcaa      240

ccggaggatt tcgccaccta ttactgtcat cagtatcatc gaagcccctt gacctttggg      300

ggagggacaa aagtggaaat aaaaggggga ggtggaagtg gtggcggtgg atctggtggc      360

ggcgggtcag aagtacagct ggttgagagt ggcgggggtc tcgtacagcc cggcgggtct      420

cttaggctct cctgtgctgc ttctggtttc tccttgacta aatacggggt acattgggtt      480

cgccaggccc ctggcaaagg tcttgaatgg gtgggcgtca agtgggctgg cggaagcact      540

gattataatt ccgcattgat gtcccgattc actatttcta aggataatgc caagaacagt      600

ctctatttgc aaatgaactc cctgagagcg gaggatactg ccgtttacta ctgtgcacgg      660

gatcaccgag acgctatgga ttactggggt cagggtaccc tggtgaccgt aagctcc         717


<210>  134
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 scFv VHVL

<400>  134
gaggttcagt tggtagagtc aggcggtggt ctggtgcagc caggtgggtc cctgcgcctc       60

agctgtgcag cttccggctt tactttctca aggaatggta tgtcctgggt acggcaaacg      120

ccggacaaac gccttgagtg ggtagctacc gtatcctctg ggggctctta catatactat      180

gcagactctg tgaaaggaag atttacaatt tcacgcgaca atgcaaaaaa tagtttgtac      240

ctccaaatgt ctagtcttag ggccgaggat actgccgtct actactgtgc acgccaggga      300

acgacggctc ttgctacccg atttttcgac gtttggggcc aaggaacgtt ggtgacagtt      360

agcagtggtg gaggtgggtc tggcggaggt ggaagtggtg gaggcgggtc cgacatccaa      420

atgactcaga gcccctctag cctcagtgca agcgtcggag accgggtgac catcacctgt      480

aaagcgtccc aggatgttgg aacggcagta gcttggtatc aacaaatccc agggaaggct      540

ccaaagctcc ttatatactc tgctagttac aggtccaccg gggtgcccga ccgattctct      600

ggctccggga gcggcactga cttttcattc atcattagta gtcttcaacc tgaggacttt      660

gccacctatt attgccagca ccactactct gcgccgtgga ctttcggagg aggcacgaag      720

gttgaaatta aa                                                          732


<210>  135
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08 scFv VLVH

<400>  135
gacatccaaa tgactcagag cccctctagc ctcagtgcaa gcgtcggaga ccgggtgacc       60

atcacctgta aagcgtccca ggatgttgga acggcagtag cttggtatca acaaatccca      120

gggaaggctc caaagctcct tatatactct gctagttaca ggtccaccgg ggtgcccgac      180

cgattctctg gctccgggag cggcactgac ttttcattca tcattagtag tcttcaacct      240

gaggactttg ccacctatta ttgccagcac cactactctg cgccgtggac tttcggagga      300

ggcacgaagg ttgaaattaa aggtggaggt gggtctggcg gaggtggaag tggtggaggc      360

gggtccgagg ttcagttggt agagtcaggc ggtggtctgg tgcagccagg tgggtccctg      420

cgcctcagct gtgcagcttc cggctttact ttctcaagga atggtatgtc ctgggtacgg      480

caaacgccgg acaaacgcct tgagtgggta gctaccgtat cctctggggg ctcttacata      540

tactatgcag actctgtgaa aggaagattt acaatttcac gcgacaatgc aaaaaatagt      600

ttgtacctcc aaatgtctag tcttagggcc gaggatactg ccgtctacta ctgtgcacgc      660

cagggaacga cggctcttgc tacccgattt ttcgacgttt ggggccaagg aacgttggtg      720

acagttagca gt                                                          732


<210>  136
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  136
ggcggaggag gaagt                                                        15


<210>  137
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  137
ggaggaggag gaagt                                                        15


<210>  138
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu07 scFv VHVL

<400>  138
gaagtacagc tggttgagag tggcgggggt ctcgtacagc ccggcgggtc tcttaggctc       60

tcctgtgctg cttctggttt ctccttgact aaatacgggg tacattgggt tcgccaggcc      120

cctggcaaag gtcttgaatg ggtgggcgtc aagtgggctg gcggaagcac tgattataat      180

tccgcattga tgtcccgatt cactatttct aaggataatg ccaagaacag tctctatttg      240

caaatgaact ccctgagagc ggaggatact gccgtttact actgtgcacg ggatcaccga      300

gacgctatgg attactgggg tcagggtacc ctggtgaccg taagctccgg gggaggtgga      360

agtggtggcg gtggatctgg tggcggcggg tcagacatac aaatgacaca gtccccctca      420

tccttgtctg cttccgtagg agaccgggtt accatcacgt gcaccgcttc tttgtccgtt      480

tcaagtacct acctccactg gtaccagcaa aaacccggca gcagccccaa gttgtggatt      540

tactcaactt ctaacttggc ctcaggggta ccgtcaagat ttagcggatc tggcagtggc      600

acgagttata ctttgacgat atcaagcctt caaccggagg atttcgcc                   648


<210>  139
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806 VH

<400>  139
gatgtccagc tgcaagagtc tggccctagc ctggtcaagc ctagccagag cctgagcctg       60

acatgtaccg tgaccggcta cagcatcacc agcgacttcg cctggaactg gatcagacag      120

ttccccggca acaagctgga atggatgggc tacatcagct acagcggcaa cacccggtac      180

aaccccagcc tgaagtcccg gatctccatc accagagaca ccagcaagaa ccagttcttc      240

ctgcagctga acagcgtgac catcgaggac accgccacct actactgtgt gacagccggc      300

agaggcttcc cttattgggg acagggaacc ctggtcacag tgtctgct                   348


<210>  140
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806 VL

<400>  140
gatatcctga tgacacagag ccccagcagc atgtctgtgt ccctgggcga taccgtgtcc       60

atcacctgtc acagcagcca ggacatcaac agcaacatcg gctggctgca gcagaggcct      120

ggcaagtctt ttaagggcct gatctaccac ggcaccaacc tggatgatga ggtgcccagc      180

agattttccg gctctggaag cggagccgac tactccctga caatcagcag cctggaaagc      240

gaggacttcg ccgattacta ctgcgtgcag tacgcccagt ttccttggac ctttggaggc      300

ggcacaaagc tggaaatcaa gcgg                                             324


<210>  141
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806 scFv VLVH

<400>  141
gatattctga tgactcaatc tccgtcttct atgagcgtga gcttgggtga caccgtcagc       60

atcacctgtc attccagcca ggatataaac tcaaatatcg gctggctcca gcaacgccca      120

ggcaagtcat tcaaggggct tatttatcat ggcaccaatc ttgacgatga agtcccatca      180

cgcttcagcg gatcaggctc aggtgcggac tattccttga ctataagttc cctcgaatct      240

gaggatttcg ccgactatta ttgcgtacaa tacgcccagt ttccctggac cttcggaggc      300

ggcaccaaat tggagataaa aaggggtgga ggaggatcag gcgggggtgg aagcggcgga      360

ggaggcagcg acgtacaact gcaagaatcc gggccgagtt tggtcaagcc ctctcaatct      420

ctttctctca cttgcacggt caccggatac tccataacca gcgattttgc gtggaattgg      480

attcgacaat ttccagggaa taaattggaa tggatgggat atatcagtta ttctggtaat      540

accagataca acccgtcatt gaaaagtcgc atctctataa cacgagacac ttcaaagaat      600

cagttcttcc ttcagctcaa ttctgtaacc atcgaagata ctgctactta ttactgtgta      660

acggcgggtc gaggattccc ctactggggc cagggtacac tggttactgt ttccgcc         717


<210>  142
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 scFv VLVH

<400>  142

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln 
        115                 120                 125             


Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr 
    130                 135                 140                 


Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Phe Ala Trp Asn Trp 
145                 150                 155                 160 


Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Ser 
                165                 170                 175     


Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser 
            180                 185                 190         


Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser 
        195                 200                 205             


Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys Val Thr Ala Gly Arg 
    210                 215                 220                 


Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
225                 230                 235                 


<210>  143
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 LCDR2

<400>  143

His Gly Ile Asn Leu Asp Asp 
1               5           


<210>  144
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 Human VH

<400>  144

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Gln Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  145
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 Mature Human VH

<400>  145

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Arg Asp 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asn Gly Asn Thr Arg Tyr Gln Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Thr Ala Ser Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  146
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 Human VL

<400>  146

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  147
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806 Mature Human VL

<400>  147

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Asp Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  148
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  148

Gly Ser Gly Gly Ser 
1               5   


<210>  149
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  149

Gly Gly Gly Ser 
1               


<210>  150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  150

Gly Gly Gly Gly Ser 
1               5   


<210>  151
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  151

Gly Gly Ser Gly 
1               


<210>  152
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  152

Gly Gly Ser Gly Gly 
1               5   


<210>  153
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  153

Gly Ser Gly Ser Gly 
1               5   


<210>  154
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  154

Gly Ser Gly Gly Gly 
1               5   


<210>  155
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  155

Gly Gly Gly Ser Gly 
1               5   


<210>  156
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  156

Gly Ser Ser Ser Gly 
1               5   


<210>  157
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  157

Gly Gly Gly Gly Ser 
1               5   


<210>  158
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  158

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  159
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  159

Gly Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Cys Thr Cys Gly Gly 
1               5                   10                  15      


Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Gly Thr Cys Gly Gly Gly 
            20                  25                  30          


Thr Gly Gly Cys Gly Gly Cys Gly Gly Ala Thr Cys Thr 
        35                  40                  45  


<210>  160
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  160

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  161
<211>  286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  inducible promoter

<400>  161
cccgatgttt tctgagttac ttttgtatcc ccaccccccc tcgaggagga aaaactgttt       60

catacagaag gcgtacgcct tctgtatgaa acagtttttc ctccacgcct tctgtatgaa      120

acagtttttc ctccacgtgg acattttgac acccccataa tatttttcca gaattaacag      180

tataaattgc atctcttgtt caagagttcc ctatcactct ctttaatcac tactcacagt      240

aacctcaact cctgcccaag cttggcattc cggtactgtt ggtaaa                     286


<210>  162
<211>  431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  inducible promoter

<400>  162
cccgatgttt tctgagttac ttttgtatcc ccaccccccc tcgaggagga aaaactgttt       60

catacagaag gcgtacgcct tctgtatgaa acagtttttc ctccacgcct tctgtatgaa      120

acagtttttc ctccacgtgg ttaaccccga tgttttctga gttacttttg tatccccacc      180

ccccctcgag gaggaaaaac tgtttcatac agaaggcgta cgccttctgt atgaaacagt      240

ttttcctcca cgccttctgt atgaaacagt ttttcctcca cgtggacatt ttgacacccc      300

cataatattt ttccagaatt aacagtataa attgcatctc ttgttcaaga gttccctatc      360

actctcttta atcactactc acagtaacct caactcctgc ccaagcttgg cattccggta      420

ctgttggtaa a                                                           431


<210>  163
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tandem CAR with 5AA linker

<400>  163

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Leu Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Met Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser 
        35                  40                  45              


Ser Gln Asp Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly 
    50                  55                  60                  


Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val 
            100                 105                 110         


Gln Tyr Ala Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
                165                 170                 175     


Ser Asp Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
            180                 185                 190         


Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro 
        195                 200                 205             


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
    210                 215                 220                 


Phe Phe Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
            260                 265                 270         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        275                 280                 285             


Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr 
305                 310                 315                 320 


Arg Ser Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Ser Phe Ile Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                405                 410                 415     


Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
            420                 425                 430         


Arg Leu Glu Trp Val Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr 
        435                 440                 445             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    450                 455                 460                 


Lys Asn Ser Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
465                 470                 475                 480 


Ala Val Tyr Tyr Cys Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg 
                485                 490                 495     


Phe Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser 
            500                 505                 510         


Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        515                 520                 525             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    530                 535                 540                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
545                 550                 555                 560 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                565                 570                 575     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            580                 585                 590         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        595                 600                 605             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    610                 615                 620                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
625                 630                 635                 640 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                645                 650                 655     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            660                 665                 670         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        675                 680                 685             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    690                 695                 700                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
705                 710                 715                 720 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730                 735     


<210>  164
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tandem CAR with 5AA linker

<400>  164
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg atattctgat gactcaatct ccgtcttcta tgagcgtgag cttgggtgac      120

accgtcagca tcacctgtca ttccagccag gatataaact caaatatcgg ctggctccag      180

caacgcccag gcaagtcatt caaggggctt atttatcatg gcaccaatct tgacgatgaa      240

gtcccatcac gcttcagcgg atcaggctca ggtgcggact attccttgac tataagttcc      300

ctcgaatctg aggatttcgc cgactattat tgcgtacaat acgcccagtt tccctggacc      360

ttcggaggcg gcaccaaatt ggagataaaa aggggtggag gaggatcagg cgggggtgga      420

agcggcggag gaggcagcga cgtacaactg caagaatccg ggccgagttt ggtcaagccc      480

tctcaatctc tttctctcac ttgcacggtc accggatact ccataaccag cgattttgcg      540

tggaattgga ttcgacaatt tccagggaat aaattggaat ggatgggata tatcagttat      600

tctggtaata ccagatacaa cccgtcattg aaaagtcgca tctctataac acgagacact      660

tcaaagaatc agttcttcct tcagctcaat tctgtaacca tcgaagatac tgctacttat      720

tactgtgtaa cggcgggtcg aggattcccc tactggggcc agggtacact ggttactgtt      780

agcgctggtg gaggaggctc tgacatccaa atgactcaga gcccctctag cctcagtgca      840

agcgtcggag accgggtgac catcacctgt aaagcgtccc aggatgttgg aacggcagta      900

gcttggtatc aacaaatccc agggaaggct ccaaagctcc ttatatactc tgctagttac      960

aggtccaccg gggtgcccga ccgattctct ggctccggga gcggcactga cttttcattc     1020

atcattagta gtcttcaacc tgaggacttt gccacctatt attgccagca ccactactct     1080

gcgccgtgga ctttcggagg aggcacgaag gttgaaatta aaggtggagg tgggtctggc     1140

ggaggtggaa gtggtggagg cgggtccgag gttcagttgg tagagtcagg cggtggtctg     1200

gtgcagccag gtgggtccct gcgcctcagc tgtgcagctt ccggctttac tttctcaagg     1260

aatggtatgt cctgggtacg gcaaacgccg gacaaacgcc ttgagtgggt agctaccgta     1320

tcctctgggg gctcttacat atactatgca gactctgtga aaggaagatt tacaatttca     1380

cgcgacaatg caaaaaatag tttgtacctc caaatgtcta gtcttagggc cgaggatact     1440

gccgtctact actgtgcacg ccagggaacg acggctcttg ctacccgatt tttcgacgtt     1500

tggggccaag gaacgttggt gacagttagc agttccggaa ccacgacgcc agcgccgcga     1560

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc     1620

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac     1680

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     1740

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1800

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1860

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     1920

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1980

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     2040

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     2100

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     2160

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta a              2211


<210>  165
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tandem CAR with 10AA linker

<400>  165

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Leu Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Met Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser 
        35                  40                  45              


Ser Gln Asp Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly 
    50                  55                  60                  


Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val 
            100                 105                 110         


Gln Tyr Ala Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
                165                 170                 175     


Ser Asp Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
            180                 185                 190         


Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro 
        195                 200                 205             


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
    210                 215                 220                 


Phe Phe Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
        275                 280                 285             


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
    290                 295                 300                 


Val Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile 
305                 310                 315                 320 


Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Asp Arg Phe Ser Gly 
                325                 330                 335     


Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser Ser Leu Gln Pro 
            340                 345                 350         


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp 
        355                 360                 365             


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
385                 390                 395                 400 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                405                 410                 415     


Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg 
            420                 425                 430         


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Thr Val Ser Ser Gly 
        435                 440                 445             


Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    450                 455                 460                 


Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Ser Ser Leu 
465                 470                 475                 480 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Thr Thr 
                485                 490                 495     


Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly Gln Gly Thr Leu Val 
            500                 505                 510         


Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
        515                 520                 525             


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
    530                 535                 540                 


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
545                 550                 555                 560 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
                565                 570                 575     


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
            580                 585                 590         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        595                 600                 605             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    610                 615                 620                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
625                 630                 635                 640 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                645                 650                 655     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            660                 665                 670         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        675                 680                 685             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    690                 695                 700                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
705                 710                 715                 720 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                725                 730                 735     


Ala Leu Pro Pro Arg 
            740     


<210>  166
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tandem CAR with 10AA linker

<400>  166
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg atattctgat gactcaatct ccgtcttcta tgagcgtgag cttgggtgac      120

accgtcagca tcacctgtca ttccagccag gatataaact caaatatcgg ctggctccag      180

caacgcccag gcaagtcatt caaggggctt atttatcatg gcaccaatct tgacgatgaa      240

gtcccatcac gcttcagcgg atcaggctca ggtgcggact attccttgac tataagttcc      300

ctcgaatctg aggatttcgc cgactattat tgcgtacaat acgcccagtt tccctggacc      360

ttcggaggcg gcaccaaatt ggagataaaa aggggtggag gaggatcagg cgggggtgga      420

agcggcggag gaggcagcga cgtacaactg caagaatccg ggccgagttt ggtcaagccc      480

tctcaatctc tttctctcac ttgcacggtc accggatact ccataaccag cgattttgcg      540

tggaattgga ttcgacaatt tccagggaat aaattggaat ggatgggata tatcagttat      600

tctggtaata ccagatacaa cccgtcattg aaaagtcgca tctctataac acgagacact      660

tcaaagaatc agttcttcct tcagctcaat tctgtaacca tcgaagatac tgctacttat      720

tactgtgtaa cggcgggtcg aggattcccc tactggggcc agggtacact ggttactgtt      780

agcgctggtg gaggaggctc tggcggtggt ggcagtgaca tccaaatgac tcagagcccc      840

tctagcctca gtgcaagcgt cggagaccgg gtgaccatca cctgtaaagc gtcccaggat      900

gttggaacgg cagtagcttg gtatcaacaa atcccaggga aggctccaaa gctccttata      960

tactctgcta gttacaggtc caccggggtg cccgaccgat tctctggctc cgggagcggc     1020

actgactttt cattcatcat tagtagtctt caacctgagg actttgccac ctattattgc     1080

cagcaccact actctgcgcc gtggactttc ggaggaggca cgaaggttga aattaaaggt     1140

ggaggtgggt ctggcggagg tggaagtggt ggaggcgggt ccgaggttca gttggtagag     1200

tcaggcggtg gtctggtgca gccaggtggg tccctgcgcc tcagctgtgc agcttccggc     1260

tttactttct caaggaatgg tatgtcctgg gtacggcaaa cgccggacaa acgccttgag     1320

tgggtagcta ccgtatcctc tgggggctct tacatatact atgcagactc tgtgaaagga     1380

agatttacaa tttcacgcga caatgcaaaa aatagtttgt acctccaaat gtctagtctt     1440

agggccgagg atactgccgt ctactactgt gcacgccagg gaacgacggc tcttgctacc     1500

cgatttttcg acgtttgggg ccaaggaacg ttggtgacag ttagcagttc cggaaccacg     1560

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg     1620

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc     1680

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca     1740

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1800

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1860

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1920

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1980

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     2040

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     2100

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     2160

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     2220

cgctaa                                                                2226


<210>  167
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tandem CAR with 15AA linker

<400>  167

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Leu Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Met Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser 
        35                  40                  45              


Ser Gln Asp Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly 
    50                  55                  60                  


Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val 
            100                 105                 110         


Gln Tyr Ala Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
                165                 170                 175     


Ser Asp Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
            180                 185                 190         


Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro 
        195                 200                 205             


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
    210                 215                 220                 


Phe Phe Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
        275                 280                 285             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
    290                 295                 300                 


Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala 
305                 310                 315                 320 


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro 
                325                 330                 335     


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile 
            340                 345                 350         


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His 
        355                 360                 365             


Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
385                 390                 395                 400 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                405                 410                 415     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly 
            420                 425                 430         


Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala 
        435                 440                 445             


Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
465                 470                 475                 480 


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly 
            500                 505                 510         


Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala 
        515                 520                 525             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    530                 535                 540                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
545                 550                 555                 560 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                565                 570                 575     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            580                 585                 590         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        595                 600                 605             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    610                 615                 620                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
625                 630                 635                 640 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
                645                 650                 655     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            660                 665                 670         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        675                 680                 685             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    690                 695                 700                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
705                 710                 715                 720 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                725                 730                 735     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745     


<210>  168
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tandem CAR with 15AA linker

<400>  168
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg atattctgat gactcaatct ccgtcttcta tgagcgtgag cttgggtgac      120

accgtcagca tcacctgtca ttccagccag gatataaact caaatatcgg ctggctccag      180

caacgcccag gcaagtcatt caaggggctt atttatcatg gcaccaatct tgacgatgaa      240

gtcccatcac gcttcagcgg atcaggctca ggtgcggact attccttgac tataagttcc      300

ctcgaatctg aggatttcgc cgactattat tgcgtacaat acgcccagtt tccctggacc      360

ttcggaggcg gcaccaaatt ggagataaaa aggggtggag gaggatcagg cgggggtgga      420

agcggcggag gaggcagcga cgtacaactg caagaatccg ggccgagttt ggtcaagccc      480

tctcaatctc tttctctcac ttgcacggtc accggatact ccataaccag cgattttgcg      540

tggaattgga ttcgacaatt tccagggaat aaattggaat ggatgggata tatcagttat      600

tctggtaata ccagatacaa cccgtcattg aaaagtcgca tctctataac acgagacact      660

tcaaagaatc agttcttcct tcagctcaat tctgtaacca tcgaagatac tgctacttat      720

tactgtgtaa cggcgggtcg aggattcccc tactggggcc agggtacact ggttactgtt      780

agcgctggtg gaggaggctc tggcggtggt ggcagtggag ggggaggttc tgacatccaa      840

atgactcaga gcccctctag cctcagtgca agcgtcggag accgggtgac catcacctgt      900

aaagcgtccc aggatgttgg aacggcagta gcttggtatc aacaaatccc agggaaggct      960

ccaaagctcc ttatatactc tgctagttac aggtccaccg gggtgcccga ccgattctct     1020

ggctccggga gcggcactga cttttcattc atcattagta gtcttcaacc tgaggacttt     1080

gccacctatt attgccagca ccactactct gcgccgtgga ctttcggagg aggcacgaag     1140

gttgaaatta aaggtggagg tgggtctggc ggaggtggaa gtggtggagg cgggtccgag     1200

gttcagttgg tagagtcagg cggtggtctg gtgcagccag gtgggtccct gcgcctcagc     1260

tgtgcagctt ccggctttac tttctcaagg aatggtatgt cctgggtacg gcaaacgccg     1320

gacaaacgcc ttgagtgggt agctaccgta tcctctgggg gctcttacat atactatgca     1380

gactctgtga aaggaagatt tacaatttca cgcgacaatg caaaaaatag tttgtacctc     1440

caaatgtcta gtcttagggc cgaggatact gccgtctact actgtgcacg ccagggaacg     1500

acggctcttg ctacccgatt tttcgacgtt tggggccaag gaacgttggt gacagttagc     1560

agttccggaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg     1620

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg     1680

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg     1740

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1800

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1860

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1920

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1980

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     2040

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     2100

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     2160

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     2220

caggccctgc cccctcgcta a                                               2241


<210>  169
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tandem CAR with 20AA linker

<400>  169

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Leu Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Met Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser 
        35                  40                  45              


Ser Gln Asp Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly 
    50                  55                  60                  


Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val 
            100                 105                 110         


Gln Tyr Ala Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
                165                 170                 175     


Ser Asp Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
            180                 185                 190         


Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro 
        195                 200                 205             


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
    210                 215                 220                 


Phe Phe Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        275                 280                 285             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    290                 295                 300                 


Cys Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln 
305                 310                 315                 320 


Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg 
                325                 330                 335     


Ser Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            340                 345                 350         


Phe Ser Phe Ile Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        355                 360                 365             


Tyr Cys Gln His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr 
    370                 375                 380                 


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                405                 410                 415     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            420                 425                 430         


Phe Ser Arg Asn Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg 
        435                 440                 445             


Leu Glu Trp Val Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr 
    450                 455                 460                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
465                 470                 475                 480 


Asn Ser Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
                485                 490                 495     


Val Tyr Tyr Cys Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe 
            500                 505                 510         


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly 
        515                 520                 525             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    530                 535                 540                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
545                 550                 555                 560 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                565                 570                 575     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            580                 585                 590         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        595                 600                 605             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    610                 615                 620                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
625                 630                 635                 640 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                645                 650                 655     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            660                 665                 670         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        675                 680                 685             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    690                 695                 700                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
705                 710                 715                 720 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                725                 730                 735     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 750     


<210>  170
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tandem CAR with 20AA linker

<400>  170
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg atattctgat gactcaatct ccgtcttcta tgagcgtgag cttgggtgac      120

accgtcagca tcacctgtca ttccagccag gatataaact caaatatcgg ctggctccag      180

caacgcccag gcaagtcatt caaggggctt atttatcatg gcaccaatct tgacgatgaa      240

gtcccatcac gcttcagcgg atcaggctca ggtgcggact attccttgac tataagttcc      300

ctcgaatctg aggatttcgc cgactattat tgcgtacaat acgcccagtt tccctggacc      360

ttcggaggcg gcaccaaatt ggagataaaa aggggtggag gaggatcagg cgggggtgga      420

agcggcggag gaggcagcga cgtacaactg caagaatccg ggccgagttt ggtcaagccc      480

tctcaatctc tttctctcac ttgcacggtc accggatact ccataaccag cgattttgcg      540

tggaattgga ttcgacaatt tccagggaat aaattggaat ggatgggata tatcagttat      600

tctggtaata ccagatacaa cccgtcattg aaaagtcgca tctctataac acgagacact      660

tcaaagaatc agttcttcct tcagctcaat tctgtaacca tcgaagatac tgctacttat      720

tactgtgtaa cggcgggtcg aggattcccc tactggggcc agggtacact ggttactgtt      780

agcgctggtg gaggaggctc tggcggtggt ggcagtggag ggggaggttc tgggggaggt      840

gggagtgaca tccaaatgac tcagagcccc tctagcctca gtgcaagcgt cggagaccgg      900

gtgaccatca cctgtaaagc gtcccaggat gttggaacgg cagtagcttg gtatcaacaa      960

atcccaggga aggctccaaa gctccttata tactctgcta gttacaggtc caccggggtg     1020

cccgaccgat tctctggctc cgggagcggc actgactttt cattcatcat tagtagtctt     1080

caacctgagg actttgccac ctattattgc cagcaccact actctgcgcc gtggactttc     1140

ggaggaggca cgaaggttga aattaaaggt ggaggtgggt ctggcggagg tggaagtggt     1200

ggaggcgggt ccgaggttca gttggtagag tcaggcggtg gtctggtgca gccaggtggg     1260

tccctgcgcc tcagctgtgc agcttccggc tttactttct caaggaatgg tatgtcctgg     1320

gtacggcaaa cgccggacaa acgccttgag tgggtagcta ccgtatcctc tgggggctct     1380

tacatatact atgcagactc tgtgaaagga agatttacaa tttcacgcga caatgcaaaa     1440

aatagtttgt acctccaaat gtctagtctt agggccgagg atactgccgt ctactactgt     1500

gcacgccagg gaacgacggc tcttgctacc cgatttttcg acgtttgggg ccaaggaacg     1560

ttggtgacag ttagcagttc cggaaccacg acgccagcgc cgcgaccacc aacaccggcg     1620

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg     1680

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg     1740

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1800

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1860

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1920

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1980

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     2040

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     2100

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     2160

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     2220

gacgcccttc acatgcaggc cctgccccct cgctaa                               2256


<210>  171
<211>  1001
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Parallel CAR 2A

<400>  171

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser 
    50                  55                  60                  


Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr 
            100                 105                 110         


Ala Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
                165                 170                 175     


Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
            180                 185                 190         


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu 
        195                 200                 205             


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
    210                 215                 220                 


Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys 
225                 230                 235                 240 


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg Val Asn Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Arg Met Ala Leu 
            500                 505                 510         


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
        515                 520                 525             


Arg Pro Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    530                 535                 540                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
545                 550                 555                 560 


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro 
                565                 570                 575     


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Asp 
            580                 585                 590         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser 
        595                 600                 605             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr 
    610                 615                 620                 


Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
                645                 650                 655     


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            660                 665                 670         


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly Met 
        675                 680                 685             


Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Thr 
    690                 695                 700                 


Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
705                 710                 715                 720 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
                725                 730                 735     


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            740                 745                 750         


Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly Gln 
        755                 760                 765             


Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro 
    770                 775                 780                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
785                 790                 795                 800 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                805                 810                 815     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            820                 825                 830         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        835                 840                 845             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    850                 855                 860                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
865                 870                 875                 880 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                885                 890                 895     


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            900                 905                 910         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        915                 920                 925             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    930                 935                 940                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
945                 950                 955                 960 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                965                 970                 975     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            980                 985                 990         


Leu His Met Gln Ala Leu Pro Pro  Arg 
        995                 1000     


<210>  172
<211>  3006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Parallel CAR 2A

<400>  172
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgatattc tgatgactca atctccgtct tctatgagcg tgagcttggg tgacaccgtc      120

agcatcacct gtcattccag ccaggatata aactcaaata tcggctggct ccagcaacgc      180

ccaggcaagt cattcaaggg gcttatttat catggcacca atcttgacga tgaagtccca      240

tcacgcttca gcggatcagg ctcaggtgcg gactattcct tgactataag ttccctcgaa      300

tctgaggatt tcgccgacta ttattgcgta caatacgccc agtttccctg gaccttcgga      360

ggcggcacca aattggagat aaaaaggggt ggaggaggat caggcggggg tggaagcggc      420

ggaggaggca gcgacgtaca actgcaagaa tccgggccga gtttggtcaa gccctctcaa      480

tctctttctc tcacttgcac ggtcaccgga tactccataa ccagcgattt tgcgtggaat      540

tggattcgac aatttccagg gaataaattg gaatggatgg gatatatcag ttattctggt      600

aataccagat acaacccgtc attgaaaagt cgcatctcta taacacgaga cacttcaaag      660

aatcagttct tccttcagct caattctgta accatcgaag atactgctac ttattactgt      720

gtaacggcgg gtcgaggatt cccctactgg ggccagggta cactggttac tgtttccgcc      780

accactaccc cagcaccgag gccacccacc ccggctccta ccatcgcctc ccagcctctg      840

tccctgcgtc cggaggcatg tagacccgca gctggtgggg ccgtgcatac ccggggtctt      900

gacttcgcct gcgatatcta catttgggcc cctctggctg gtacttgcgg ggtcctgctg      960

ctttcactcg tgatcactct ttactgtaag cgcggtcgga agaagctgct gtacatcttt     1020

aagcaaccct tcatgaggcc tgtgcagact actcaagagg aggacggctg ttcatgccgg     1080

ttcccagagg aggaggaagg cggctgcgaa ctgcgcgtga aattcagccg cagcgcagat     1140

gctccagcct acaagcaggg gcagaaccag ctctacaacg aactcaatct tggtcggaga     1200

gaggagtacg acgtgctgga caagcggaga ggacgggacc cagaaatggg cgggaagccg     1260

cgcagaaaga atccccaaga gggcctgtac aacgagctcc aaaaggataa gatggcagaa     1320

gcctatagcg agattggtat gaaaggggaa cgcagaagag gcaaaggcca cgacggactg     1380

taccagggac tcagcaccgc caccaaggac acctatgacg ctcttcacat gcaggccctg     1440

ccgcctcggg ttaacggctc cggcgctaca aactttagtc tgctgaaaca ggctggagat     1500

gtggaggaaa accccggccc ttctagaatg gccttaccag tgaccgcctt gctcctgccg     1560

ctggccttgc tgctccacgc cgccaggccg ggatccgaca tccaaatgac tcagagcccc     1620

tctagcctca gtgcaagcgt cggagaccgg gtgaccatca cctgtaaagc gtcccaggat     1680

gttggaacgg cagtagcttg gtatcaacaa atcccaggga aggctccaaa gctccttata     1740

tactctgcta gttacaggtc caccggggtg cccgaccgat tctctggctc cgggagcggc     1800

actgactttt cattcatcat tagtagtctt caacctgagg actttgccac ctattattgc     1860

cagcaccact actctgcgcc gtggactttc ggaggaggca cgaaggttga aattaaaggt     1920

ggaggtgggt ctggcggagg tggaagtggt ggaggcgggt ccgaggttca gttggtagag     1980

tcaggcggtg gtctggtgca gccaggtggg tccctgcgcc tcagctgtgc agcttccggc     2040

tttactttct caaggaatgg tatgtcctgg gtacggcaaa cgccggacaa acgccttgag     2100

tgggtagcta ccgtatcctc tgggggctct tacatatact atgcagactc tgtgaaagga     2160

agatttacaa tttcacgcga caatgcaaaa aatagtttgt acctccaaat gtctagtctt     2220

agggccgagg atactgccgt ctactactgt gcacgccagg gaacgacggc tcttgctacc     2280

cgatttttcg acgtttgggg ccaaggaacg ttggtgacag ttagcagttc cggaaccacg     2340

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg     2400

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc     2460

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca     2520

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     2580

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     2640

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     2700

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     2760

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     2820

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     2880

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     2940

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     3000

cgctaa                                                                3006


<210>  173
<211>  1261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806BBzHu08BBz

<400>  173

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser 
    50                  55                  60                  


Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr 
            100                 105                 110         


Ala Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
                165                 170                 175     


Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
            180                 185                 190         


Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu 
        195                 200                 205             


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
    210                 215                 220                 


Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys 
225                 230                 235                 240 


Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg Val Asn Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Arg Met Ala Leu 
            500                 505                 510         


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
        515                 520                 525             


Arg Pro Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
    530                 535                 540                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
545                 550                 555                 560 


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro 
                565                 570                 575     


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Asp 
            580                 585                 590         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser 
        595                 600                 605             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr 
    610                 615                 620                 


Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
                645                 650                 655     


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            660                 665                 670         


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly Met 
        675                 680                 685             


Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Thr 
    690                 695                 700                 


Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
705                 710                 715                 720 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
                725                 730                 735     


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            740                 745                 750         


Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly Gln 
        755                 760                 765             


Gly Thr Leu Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro 
    770                 775                 780                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
785                 790                 795                 800 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                805                 810                 815     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            820                 825                 830         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        835                 840                 845             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    850                 855                 860                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
865                 870                 875                 880 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                885                 890                 895     


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            900                 905                 910         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        915                 920                 925             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    930                 935                 940                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
945                 950                 955                 960 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                965                 970                 975     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            980                 985                 990         


Leu His Met Gln Ala Leu Pro Pro  Arg Thr Ser Gly Ser  Gly Glu Gly 
        995                 1000                 1005             


Arg Gly  Ser Leu Leu Thr Cys  Gly Asp Val Glu Glu  Asn Pro Gly 
    1010                 1015                 1020             


Pro Arg  Met Val Ser Lys Gly  Glu Glu Asp Asn Met  Ala Ile Ile 
    1025                 1030                 1035             


Lys Glu  Phe Met Arg Phe Lys  Val His Met Glu Gly  Ser Val Asn 
    1040                 1045                 1050             


Gly His  Glu Phe Glu Ile Glu  Gly Glu Gly Glu Gly  Arg Pro Tyr 
    1055                 1060                 1065             


Glu Gly  Thr Gln Thr Ala Lys  Leu Lys Val Thr Lys  Gly Gly Pro 
    1070                 1075                 1080             


Leu Pro  Phe Ala Trp Asp Ile  Leu Ser Pro Gln Phe  Met Tyr Gly 
    1085                 1090                 1095             


Ser Lys  Ala Tyr Val Lys His  Pro Ala Asp Ile Pro  Asp Tyr Leu 
    1100                 1105                 1110             


Lys Leu  Ser Phe Pro Glu Gly  Phe Lys Trp Glu Arg  Val Met Asn 
    1115                 1120                 1125             


Phe Glu  Asp Gly Gly Val Val  Thr Val Thr Gln Asp  Ser Ser Leu 
    1130                 1135                 1140             


Gln Asp  Gly Glu Phe Ile Tyr  Lys Val Lys Leu Arg  Gly Thr Asn 
    1145                 1150                 1155             


Phe Pro  Ser Asp Gly Pro Val  Met Gln Lys Lys Thr  Met Gly Trp 
    1160                 1165                 1170             


Glu Ala  Ser Ser Glu Arg Met  Tyr Pro Glu Asp Gly  Ala Leu Lys 
    1175                 1180                 1185             


Gly Glu  Ile Lys Gln Arg Leu  Lys Leu Lys Asp Gly  Gly His Tyr 
    1190                 1195                 1200             


Asp Ala  Glu Val Lys Thr Thr  Tyr Lys Ala Lys Lys  Pro Val Gln 
    1205                 1210                 1215             


Leu Pro  Gly Ala Tyr Asn Val  Asn Ile Lys Leu Asp  Ile Thr Ser 
    1220                 1225                 1230             


His Asn  Glu Asp Tyr Thr Ile  Val Glu Gln Tyr Glu  Arg Ala Glu 
    1235                 1240                 1245             


Gly Arg  His Ser Thr Gly Gly  Met Asp Glu Leu Tyr  Lys 
    1250                 1255                 1260     


<210>  174
<211>  3786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806BBzHu08BBz

<400>  174
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

cccgatattc tgatgactca atctccgtct tctatgagcg tgagcttggg tgacaccgtc      120

agcatcacct gtcattccag ccaggatata aactcaaata tcggctggct ccagcaacgc      180

ccaggcaagt cattcaaggg gcttatttat catggcacca atcttgacga tgaagtccca      240

tcacgcttca gcggatcagg ctcaggtgcg gactattcct tgactataag ttccctcgaa      300

tctgaggatt tcgccgacta ttattgcgta caatacgccc agtttccctg gaccttcgga      360

ggcggcacca aattggagat aaaaaggggt ggaggaggat caggcggggg tggaagcggc      420

ggaggaggca gcgacgtaca actgcaagaa tccgggccga gtttggtcaa gccctctcaa      480

tctctttctc tcacttgcac ggtcaccgga tactccataa ccagcgattt tgcgtggaat      540

tggattcgac aatttccagg gaataaattg gaatggatgg gatatatcag ttattctggt      600

aataccagat acaacccgtc attgaaaagt cgcatctcta taacacgaga cacttcaaag      660

aatcagttct tccttcagct caattctgta accatcgaag atactgctac ttattactgt      720

gtaacggcgg gtcgaggatt cccctactgg ggccagggta cactggttac tgtttccgcc      780

accactaccc cagcaccgag gccacccacc ccggctccta ccatcgcctc ccagcctctg      840

tccctgcgtc cggaggcatg tagacccgca gctggtgggg ccgtgcatac ccggggtctt      900

gacttcgcct gcgatatcta catttgggcc cctctggctg gtacttgcgg ggtcctgctg      960

ctttcactcg tgatcactct ttactgtaag cgcggtcgga agaagctgct gtacatcttt     1020

aagcaaccct tcatgaggcc tgtgcagact actcaagagg aggacggctg ttcatgccgg     1080

ttcccagagg aggaggaagg cggctgcgaa ctgcgcgtga aattcagccg cagcgcagat     1140

gctccagcct acaagcaggg gcagaaccag ctctacaacg aactcaatct tggtcggaga     1200

gaggagtacg acgtgctgga caagcggaga ggacgggacc cagaaatggg cgggaagccg     1260

cgcagaaaga atccccaaga gggcctgtac aacgagctcc aaaaggataa gatggcagaa     1320

gcctatagcg agattggtat gaaaggggaa cgcagaagag gcaaaggcca cgacggactg     1380

taccagggac tcagcaccgc caccaaggac acctatgacg ctcttcacat gcaggccctg     1440

ccgcctcggg ttaacggctc cggcgctaca aactttagtc tgctgaaaca ggctggagat     1500

gtggaggaaa accccggccc ttctagaatg gccttaccag tgaccgcctt gctcctgccg     1560

ctggccttgc tgctccacgc cgccaggccg ggatccgaca tccaaatgac tcagagcccc     1620

tctagcctca gtgcaagcgt cggagaccgg gtgaccatca cctgtaaagc gtcccaggat     1680

gttggaacgg cagtagcttg gtatcaacaa atcccaggga aggctccaaa gctccttata     1740

tactctgcta gttacaggtc caccggggtg cccgaccgat tctctggctc cgggagcggc     1800

actgactttt cattcatcat tagtagtctt caacctgagg actttgccac ctattattgc     1860

cagcaccact actctgcgcc gtggactttc ggaggaggca cgaaggttga aattaaaggt     1920

ggaggtgggt ctggcggagg tggaagtggt ggaggcgggt ccgaggttca gttggtagag     1980

tcaggcggtg gtctggtgca gccaggtggg tccctgcgcc tcagctgtgc agcttccggc     2040

tttactttct caaggaatgg tatgtcctgg gtacggcaaa cgccggacaa acgccttgag     2100

tgggtagcta ccgtatcctc tgggggctct tacatatact atgcagactc tgtgaaagga     2160

agatttacaa tttcacgcga caatgcaaaa aatagtttgt acctccaaat gtctagtctt     2220

agggccgagg atactgccgt ctactactgt gcacgccagg gaacgacggc tcttgctacc     2280

cgatttttcg acgtttgggg ccaaggaacg ttggtgacag ttagcagttc cggaaccacg     2340

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg     2400

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc     2460

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca     2520

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     2580

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     2640

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     2700

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     2760

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     2820

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     2880

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     2940

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     3000

cgcactagtg gcagcggaga gggcagagga agtcttctaa catgcggtga cgtggaggag     3060

aatcccggcc ctaggatggt gagcaagggc gaggaggata acatggccat catcaaggag     3120

ttcatgcgct tcaaggtgca catggagggc tccgtgaacg gccacgagtt cgagatcgag     3180

ggcgagggcg agggccgccc ctacgagggc acccagaccg ccaagctgaa ggtgaccaag     3240

ggtggccccc tgcccttcgc ctgggacatc ctgtcccctc agttcatgta cggctccaag     3300

gcctacgtga agcaccccgc cgacatcccc gactacttga agctgtcctt ccccgagggc     3360

ttcaagtggg agcgcgtgat gaacttcgag gacggcggcg tggtgaccgt gacccaggac     3420

tcctccctgc aggacggcga gttcatctac aaggtgaagc tgcgcggcac caacttcccc     3480

tccgacggcc ccgtaatgca gaagaagacc atgggctggg aggcctcctc cgagcggatg     3540

taccccgagg acggcgccct gaagggcgag atcaagcaga ggctgaagct gaaggacggc     3600

ggccactacg acgctgaggt caagaccacc tacaaggcca agaagcccgt gcagctgccc     3660

ggcgcctaca acgtcaacat caagttggac atcacctccc acaacgagga ctacaccatc     3720

gtggaacagt acgaacgcgc cgagggccgc cactccaccg gcggcatgga cgagctgtac     3780

aagtaa                                                                3786


<210>  175
<211>  1285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806BiTEHu08BBz

<400>  175

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser 
            20                  25                  30          


Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp 
        35                  40                  45              


Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe 
    50                  55                  60                  


Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala 
            100                 105                 110         


Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Phe 
                165                 170                 175     


Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met 
            180                 185                 190         


Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu Lys 
        195                 200                 205             


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
    210                 215                 220                 


Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys Val 
225                 230                 235                 240 


Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ala Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly 
            260                 265                 270         


Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr 
        275                 280                 285             


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg 
    290                 295                 300                 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
305                 310                 315                 320 


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr 
                325                 330                 335     


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
            340                 345                 350         


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
        355                 360                 365             


Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val 
    370                 375                 380                 


Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val 
385                 390                 395                 400 


Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
                405                 410                 415     


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
            420                 425                 430         


Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile 
        435                 440                 445             


Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly 
    450                 455                 460                 


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala 
465                 470                 475                 480 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu 
                485                 490                 495     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Val Asn Gly Ser Gly 
            500                 505                 510         


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
        515                 520                 525             


Pro Gly Pro Ser Arg Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
    530                 535                 540                 


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Asp Ile Gln Met 
545                 550                 555                 560 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                565                 570                 575     


Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr 
            580                 585                 590         


Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
        595                 600                 605             


Tyr Arg Ser Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    610                 615                 620                 


Thr Asp Phe Ser Phe Ile Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
625                 630                 635                 640 


Thr Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly 
                645                 650                 655     


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        675                 680                 685             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    690                 695                 700                 


Phe Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg Gln Thr Pro Asp 
705                 710                 715                 720 


Lys Arg Leu Glu Trp Val Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile 
                725                 730                 735     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            740                 745                 750         


Ala Lys Asn Ser Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
        755                 760                 765             


Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr 
    770                 775                 780                 


Arg Phe Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
785                 790                 795                 800 


Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                805                 810                 815     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            820                 825                 830         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        835                 840                 845             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    850                 855                 860                 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
865                 870                 875                 880 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                885                 890                 895     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            900                 905                 910         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        915                 920                 925             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    930                 935                 940                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
945                 950                 955                 960 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                965                 970                 975     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            980                 985                 990         


Arg Arg Arg Gly Lys Gly His Asp  Gly Leu Tyr Gln Gly  Leu Ser Thr 
        995                 1000                 1005             


Ala Thr  Lys Asp Thr Tyr Asp  Ala Leu His Met Gln  Ala Leu Pro 
    1010                 1015                 1020             


Pro Arg  Thr Ser Gly Ser Gly  Glu Gly Arg Gly Ser  Leu Leu Thr 
    1025                 1030                 1035             


Cys Gly  Asp Val Glu Glu Asn  Pro Gly Pro Arg Met  Val Ser Lys 
    1040                 1045                 1050             


Gly Glu  Glu Asp Asn Met Ala  Ile Ile Lys Glu Phe  Met Arg Phe 
    1055                 1060                 1065             


Lys Val  His Met Glu Gly Ser  Val Asn Gly His Glu  Phe Glu Ile 
    1070                 1075                 1080             


Glu Gly  Glu Gly Glu Gly Arg  Pro Tyr Glu Gly Thr  Gln Thr Ala 
    1085                 1090                 1095             


Lys Leu  Lys Val Thr Lys Gly  Gly Pro Leu Pro Phe  Ala Trp Asp 
    1100                 1105                 1110             


Ile Leu  Ser Pro Gln Phe Met  Tyr Gly Ser Lys Ala  Tyr Val Lys 
    1115                 1120                 1125             


His Pro  Ala Asp Ile Pro Asp  Tyr Leu Lys Leu Ser  Phe Pro Glu 
    1130                 1135                 1140             


Gly Phe  Lys Trp Glu Arg Val  Met Asn Phe Glu Asp  Gly Gly Val 
    1145                 1150                 1155             


Val Thr  Val Thr Gln Asp Ser  Ser Leu Gln Asp Gly  Glu Phe Ile 
    1160                 1165                 1170             


Tyr Lys  Val Lys Leu Arg Gly  Thr Asn Phe Pro Ser  Asp Gly Pro 
    1175                 1180                 1185             


Val Met  Gln Lys Lys Thr Met  Gly Trp Glu Ala Ser  Ser Glu Arg 
    1190                 1195                 1200             


Met Tyr  Pro Glu Asp Gly Ala  Leu Lys Gly Glu Ile  Lys Gln Arg 
    1205                 1210                 1215             


Leu Lys  Leu Lys Asp Gly Gly  His Tyr Asp Ala Glu  Val Lys Thr 
    1220                 1225                 1230             


Thr Tyr  Lys Ala Lys Lys Pro  Val Gln Leu Pro Gly  Ala Tyr Asn 
    1235                 1240                 1245             


Val Asn  Ile Lys Leu Asp Ile  Thr Ser His Asn Glu  Asp Tyr Thr 
    1250                 1255                 1260             


Ile Val  Glu Gln Tyr Glu Arg  Ala Glu Gly Arg His  Ser Thr Gly 
    1265                 1270                 1275             


Gly Met  Asp Glu Leu Tyr Lys  
    1280                 1285 


<210>  176
<211>  3858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806BiTEHu08BBz

<400>  176
atggaaacag atacattgtt gttgtgggta ctcctgctgt gggtccctgg gagcaccggt       60

gatattctga tgactcaatc tccgtcttct atgagcgtga gcttgggtga caccgtcagc      120

atcacctgtc attccagcca ggatataaac tcaaatatcg gctggctcca gcaacgccca      180

ggcaagtcat tcaaggggct tatttatcat ggcaccaatc ttgacgatga agtcccatca      240

cgcttcagcg gatcaggctc aggtgcggac tattccttga ctataagttc cctcgaatct      300

gaggatttcg ccgactatta ttgcgtacaa tacgcccagt ttccctggac cttcggaggc      360

ggcaccaaat tggagataaa aaggggtgga ggaggatcag gcgggggtgg aagcggcgga      420

ggaggcagcg acgtacaact gcaagaatcc gggccgagtt tggtcaagcc ctctcaatct      480

ctttctctca cttgcacggt caccggatac tccataacca gcgattttgc gtggaattgg      540

attcgacaat ttccagggaa taaattggaa tggatgggat atatcagtta ttctggtaat      600

accagataca acccgtcatt gaaaagtcgc atctctataa cacgagacac ttcaaagaat      660

cagttcttcc ttcagctcaa ttctgtaacc atcgaagata ctgctactta ttactgtgta      720

acggcgggtc gaggattccc ctactggggc cagggtacac tggttactgt ttccgccgga      780

ggaggaggaa gtgatattaa gctccagcaa tcaggggcag aattggcccg ccccggtgca      840

agcgtgaaaa tgtcctgcaa gactagcgga tacactttta ccagatacac gatgcactgg      900

gttaaacagc gaccggggca aggcttggag tggatcggat atattaaccc aagtcgcggc      960

tacacgaatt acaaccagaa attcaaagac aaggcaacac tgaccacaga taaatcatca     1020

tctaccgcgt atatgcaact gagttcactt actagcgagg attctgcggt atattactgt     1080

gcgcggtact acgacgacca ttactgtctg gactattggg gtcaaggcac cacccttact     1140

gtgagttcag tagaaggagg cagtgggggc tctggaggga gcggtggctc aggaggggta     1200

gacgacatcc aactgacgca atctccggct ataatgtcag cgtctccggg ggaaaaagta     1260

acgatgactt gtcgcgcgtc cagcagcgtc tcttatatga actggtatca acagaagagt     1320

gggacgagtc ctaagcgatg gatatatgat acaagcaaag ttgcgagcgg agtcccgtat     1380

cgcttctctg gaagtggcag cggaacctct tactccctca cgatcagcag catggaggcg     1440

gaggacgcag ccacctacta ctgtcagcag tggtcttcca accctctgac attcggagcc     1500

ggtacaaaac ttgaactgaa agttaacggc tccggcgcta caaactttag tctgctgaaa     1560

caggctggag atgtggagga aaaccccggc ccttctagaa tggccttacc agtgaccgcc     1620

ttgctcctgc cgctggcctt gctgctccac gccgccaggc cgggatccga catccaaatg     1680

actcagagcc cctctagcct cagtgcaagc gtcggagacc gggtgaccat cacctgtaaa     1740

gcgtcccagg atgttggaac ggcagtagct tggtatcaac aaatcccagg gaaggctcca     1800

aagctcctta tatactctgc tagttacagg tccaccgggg tgcccgaccg attctctggc     1860

tccgggagcg gcactgactt ttcattcatc attagtagtc ttcaacctga ggactttgcc     1920

acctattatt gccagcacca ctactctgcg ccgtggactt tcggaggagg cacgaaggtt     1980

gaaattaaag gtggaggtgg gtctggcgga ggtggaagtg gtggaggcgg gtccgaggtt     2040

cagttggtag agtcaggcgg tggtctggtg cagccaggtg ggtccctgcg cctcagctgt     2100

gcagcttccg gctttacttt ctcaaggaat ggtatgtcct gggtacggca aacgccggac     2160

aaacgccttg agtgggtagc taccgtatcc tctgggggct cttacatata ctatgcagac     2220

tctgtgaaag gaagatttac aatttcacgc gacaatgcaa aaaatagttt gtacctccaa     2280

atgtctagtc ttagggccga ggatactgcc gtctactact gtgcacgcca gggaacgacg     2340

gctcttgcta cccgattttt cgacgtttgg ggccaaggaa cgttggtgac agttagcagt     2400

tccggaacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag     2460

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg     2520

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc     2580

cttctcctgt cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat     2640

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     2700

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     2760

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     2820

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     2880

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     2940

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     3000

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     3060

gccctgcccc ctcgcactag tggcagcgga gagggcagag gaagtcttct aacatgcggt     3120

gacgtggagg agaatcccgg ccctaggatg gtgagcaagg gcgaggagga taacatggcc     3180

atcatcaagg agttcatgcg cttcaaggtg cacatggagg gctccgtgaa cggccacgag     3240

ttcgagatcg agggcgaggg cgagggccgc ccctacgagg gcacccagac cgccaagctg     3300

aaggtgacca agggtggccc cctgcccttc gcctgggaca tcctgtcccc tcagttcatg     3360

tacggctcca aggcctacgt gaagcacccc gccgacatcc ccgactactt gaagctgtcc     3420

ttccccgagg gcttcaagtg ggagcgcgtg atgaacttcg aggacggcgg cgtggtgacc     3480

gtgacccagg actcctccct gcaggacggc gagttcatct acaaggtgaa gctgcgcggc     3540

accaacttcc cctccgacgg ccccgtaatg cagaagaaga ccatgggctg ggaggcctcc     3600

tccgagcgga tgtaccccga ggacggcgcc ctgaagggcg agatcaagca gaggctgaag     3660

ctgaaggacg gcggccacta cgacgctgag gtcaagacca cctacaaggc caagaagccc     3720

gtgcagctgc ccggcgccta caacgtcaac atcaagttgg acatcacctc ccacaacgag     3780

gactacacca tcgtggaaca gtacgaacgc gccgagggcc gccactccac cggcggcatg     3840

gacgagctgt acaagtaa                                                   3858


<210>  177
<211>  1285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hu08BiTE806BBz

<400>  177

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Ile Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr 
            100                 105                 110         


Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn Gly Met 
                165                 170                 175     


Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Thr 
            180                 185                 190         


Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
    210                 215                 220                 


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe Asp Val Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Lys 
            260                 265                 270         


Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys 
        275                 280                 285             


Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
    290                 295                 300                 


Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
305                 310                 315                 320 


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys 
                325                 330                 335     


Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu 
            340                 345                 350         


Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr 
        355                 360                 365             


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
    370                 375                 380                 


Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile 
                405                 410                 415     


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
            420                 425                 430         


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
        435                 440                 445             


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro 
    450                 455                 460                 


Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
465                 470                 475                 480 


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
                485                 490                 495     


Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            500                 505                 510         


Val Asn Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        515                 520                 525             


Asp Val Glu Glu Asn Pro Gly Pro Ser Arg Met Ala Leu Pro Val Thr 
    530                 535                 540                 


Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly 
545                 550                 555                 560 


Ser Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu 
                565                 570                 575     


Gly Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser 
            580                 585                 590         


Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe Lys Gly Leu 
        595                 600                 605             


Ile Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser Arg Phe Ser 
    610                 615                 620                 


Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu 
625                 630                 635                 640 


Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro 
                645                 650                 655     


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly 
            660                 665                 670         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu 
        675                 680                 685             


Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Ser Leu Ser Leu 
    690                 695                 700                 


Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Phe Ala Trp Asn 
705                 710                 715                 720 


Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile 
                725                 730                 735     


Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu Lys Ser Arg Ile 
            740                 745                 750         


Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu Gln Leu Asn 
        755                 760                 765             


Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys Val Thr Ala Gly 
    770                 775                 780                 


Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
785                 790                 795                 800 


Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                805                 810                 815     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            820                 825                 830         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        835                 840                 845             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    850                 855                 860                 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
865                 870                 875                 880 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                885                 890                 895     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            900                 905                 910         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        915                 920                 925             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    930                 935                 940                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
945                 950                 955                 960 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                965                 970                 975     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            980                 985                 990         


Arg Arg Arg Gly Lys Gly His Asp  Gly Leu Tyr Gln Gly  Leu Ser Thr 
        995                 1000                 1005             


Ala Thr  Lys Asp Thr Tyr Asp  Ala Leu His Met Gln  Ala Leu Pro 
    1010                 1015                 1020             


Pro Arg  Thr Ser Gly Ser Gly  Glu Gly Arg Gly Ser  Leu Leu Thr 
    1025                 1030                 1035             


Cys Gly  Asp Val Glu Glu Asn  Pro Gly Pro Arg Met  Val Ser Lys 
    1040                 1045                 1050             


Gly Glu  Glu Asp Asn Met Ala  Ile Ile Lys Glu Phe  Met Arg Phe 
    1055                 1060                 1065             


Lys Val  His Met Glu Gly Ser  Val Asn Gly His Glu  Phe Glu Ile 
    1070                 1075                 1080             


Glu Gly  Glu Gly Glu Gly Arg  Pro Tyr Glu Gly Thr  Gln Thr Ala 
    1085                 1090                 1095             


Lys Leu  Lys Val Thr Lys Gly  Gly Pro Leu Pro Phe  Ala Trp Asp 
    1100                 1105                 1110             


Ile Leu  Ser Pro Gln Phe Met  Tyr Gly Ser Lys Ala  Tyr Val Lys 
    1115                 1120                 1125             


His Pro  Ala Asp Ile Pro Asp  Tyr Leu Lys Leu Ser  Phe Pro Glu 
    1130                 1135                 1140             


Gly Phe  Lys Trp Glu Arg Val  Met Asn Phe Glu Asp  Gly Gly Val 
    1145                 1150                 1155             


Val Thr  Val Thr Gln Asp Ser  Ser Leu Gln Asp Gly  Glu Phe Ile 
    1160                 1165                 1170             


Tyr Lys  Val Lys Leu Arg Gly  Thr Asn Phe Pro Ser  Asp Gly Pro 
    1175                 1180                 1185             


Val Met  Gln Lys Lys Thr Met  Gly Trp Glu Ala Ser  Ser Glu Arg 
    1190                 1195                 1200             


Met Tyr  Pro Glu Asp Gly Ala  Leu Lys Gly Glu Ile  Lys Gln Arg 
    1205                 1210                 1215             


Leu Lys  Leu Lys Asp Gly Gly  His Tyr Asp Ala Glu  Val Lys Thr 
    1220                 1225                 1230             


Thr Tyr  Lys Ala Lys Lys Pro  Val Gln Leu Pro Gly  Ala Tyr Asn 
    1235                 1240                 1245             


Val Asn  Ile Lys Leu Asp Ile  Thr Ser His Asn Glu  Asp Tyr Thr 
    1250                 1255                 1260             


Ile Val  Glu Gln Tyr Glu Arg  Ala Glu Gly Arg His  Ser Thr Gly 
    1265                 1270                 1275             


Gly Met  Asp Glu Leu Tyr Lys  
    1280                 1285 


<210>  178
<211>  3858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hu08BiTE806BBz

<400>  178
atggaaacag atacattgtt gttgtgggta ctcctgctgt gggtccctgg gagcaccggt       60

gacatccaaa tgactcagag cccctctagc ctcagtgcaa gcgtcggaga ccgggtgacc      120

atcacctgta aagcgtccca ggatgttgga acggcagtag cttggtatca acaaatccca      180

gggaaggctc caaagctcct tatatactct gctagttaca ggtccaccgg ggtgcccgac      240

cgattctctg gctccgggag cggcactgac ttttcattca tcattagtag tcttcaacct      300

gaggactttg ccacctatta ttgccagcac cactactctg cgccgtggac tttcggagga      360

ggcacgaagg ttgaaattaa aggtggaggt gggtctggcg gaggtggaag tggtggaggc      420

gggtccgagg ttcagttggt agagtcaggc ggtggtctgg tgcagccagg tgggtccctg      480

cgcctcagct gtgcagcttc cggctttact ttctcaagga atggtatgtc ctgggtacgg      540

caaacgccgg acaaacgcct tgagtgggta gctaccgtat cctctggggg ctcttacata      600

tactatgcag actctgtgaa aggaagattt acaatttcac gcgacaatgc aaaaaatagt      660

ttgtacctcc aaatgtctag tcttagggcc gaggatactg ccgtctacta ctgtgcacgc      720

cagggaacga cggctcttgc tacccgattt ttcgacgttt ggggccaagg aacgttggtg      780

acagttagca gtggaggagg aggaagtgat attaagctcc agcaatcagg ggcagaattg      840

gcccgccccg gtgcaagcgt gaaaatgtcc tgcaagacta gcggatacac ttttaccaga      900

tacacgatgc actgggttaa acagcgaccg gggcaaggct tggagtggat cggatatatt      960

aacccaagtc gcggctacac gaattacaac cagaaattca aagacaaggc aacactgacc     1020

acagataaat catcatctac cgcgtatatg caactgagtt cacttactag cgaggattct     1080

gcggtatatt actgtgcgcg gtactacgac gaccattact gtctggacta ttggggtcaa     1140

ggcaccaccc ttactgtgag ttcagtagaa ggaggcagtg ggggctctgg agggagcggt     1200

ggctcaggag gggtagacga catccaactg acgcaatctc cggctataat gtcagcgtct     1260

ccgggggaaa aagtaacgat gacttgtcgc gcgtccagca gcgtctctta tatgaactgg     1320

tatcaacaga agagtgggac gagtcctaag cgatggatat atgatacaag caaagttgcg     1380

agcggagtcc cgtatcgctt ctctggaagt ggcagcggaa cctcttactc cctcacgatc     1440

agcagcatgg aggcggagga cgcagccacc tactactgtc agcagtggtc ttccaaccct     1500

ctgacattcg gagccggtac aaaacttgaa ctgaaagtta acggctccgg cgctacaaac     1560

tttagtctgc tgaaacaggc tggagatgtg gaggaaaacc ccggcccttc tagaatggcc     1620

ctgcctgtga cagccctgct gctgcctctg gctctgctgc tgcatgccgc tagacccgga     1680

tccgatattc tgatgactca atctccgtct tctatgagcg tgagcttggg tgacaccgtc     1740

agcatcacct gtcattccag ccaggatata aactcaaata tcggctggct ccagcaacgc     1800

ccaggcaagt cattcaaggg gcttatttat catggcacca atcttgacga tgaagtccca     1860

tcacgcttca gcggatcagg ctcaggtgcg gactattcct tgactataag ttccctcgaa     1920

tctgaggatt tcgccgacta ttattgcgta caatacgccc agtttccctg gaccttcgga     1980

ggcggcacca aattggagat aaaaaggggt ggaggaggat caggcggggg tggaagcggc     2040

ggaggaggca gcgacgtaca actgcaagaa tccgggccga gtttggtcaa gccctctcaa     2100

tctctttctc tcacttgcac ggtcaccgga tactccataa ccagcgattt tgcgtggaat     2160

tggattcgac aatttccagg gaataaattg gaatggatgg gatatatcag ttattctggt     2220

aataccagat acaacccgtc attgaaaagt cgcatctcta taacacgaga cacttcaaag     2280

aatcagttct tccttcagct caattctgta accatcgaag atactgctac ttattactgt     2340

gtaacggcgg gtcgaggatt cccctactgg ggccagggta cactggttac tgtttccgcc     2400

tccggaacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag     2460

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg     2520

gggctggact tcgcctgtga tatctacatc tgggcgccct tggccgggac ttgtggggtc     2580

cttctcctgt cactggttat caccctttac tgcaaacggg gcagaaagaa actcctgtat     2640

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     2700

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     2760

gcagacgccc ccgcgtacaa gcagggccag aaccagctct ataacgagct caatctagga     2820

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     2880

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     2940

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     3000

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     3060

gccctgcccc ctcgcactag tggcagcgga gagggcagag gaagtcttct aacatgcggt     3120

gacgtggagg agaatcccgg ccctaggatg gtgagcaagg gcgaggagga taacatggcc     3180

atcatcaagg agttcatgcg cttcaaggtg cacatggagg gctccgtgaa cggccacgag     3240

ttcgagatcg agggcgaggg cgagggccgc ccctacgagg gcacccagac cgccaagctg     3300

aaggtgacca agggtggccc cctgcccttc gcctgggaca tcctgtcccc tcagttcatg     3360

tacggctcca aggcctacgt gaagcacccc gccgacatcc ccgactactt gaagctgtcc     3420

ttccccgagg gcttcaagtg ggagcgcgtg atgaacttcg aggacggcgg cgtggtgacc     3480

gtgacccagg actcctccct gcaggacggc gagttcatct acaaggtgaa gctgcgcggc     3540

accaacttcc cctccgacgg ccccgtaatg cagaagaaga ccatgggctg ggaggcctcc     3600

tccgagcgga tgtaccccga ggacggcgcc ctgaagggcg agatcaagca gaggctgaag     3660

ctgaaggacg gcggccacta cgacgctgag gtcaagacca cctacaaggc caagaagccc     3720

gtgcagctgc ccggcgccta caacgtcaac atcaagttgg acatcacctc ccacaacgag     3780

gactacacca tcgtggaaca gtacgaacgc gccgagggcc gccactccac cggcggcatg     3840

gacgagctgt acaagtaa                                                   3858


<210>  179
<211>  1305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806BiTEHu08BiTE

<400>  179

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser 
            20                  25                  30          


Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser Ser Gln Asp 
        35                  40                  45              


Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly Lys Ser Phe 
    50                  55                  60                  


Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala 
            100                 105                 110         


Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Phe 
                165                 170                 175     


Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met 
            180                 185                 190         


Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro Ser Leu Lys 
        195                 200                 205             


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
    210                 215                 220                 


Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr Tyr Cys Val 
225                 230                 235                 240 


Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ala Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly 
            260                 265                 270         


Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr 
        275                 280                 285             


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg 
    290                 295                 300                 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
305                 310                 315                 320 


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr 
                325                 330                 335     


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
            340                 345                 350         


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
        355                 360                 365             


Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val 
    370                 375                 380                 


Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val 
385                 390                 395                 400 


Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
                405                 410                 415     


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
            420                 425                 430         


Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile 
        435                 440                 445             


Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly 
    450                 455                 460                 


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala 
465                 470                 475                 480 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu 
                485                 490                 495     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Val Asn Gly Ser Gly 
            500                 505                 510         


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
        515                 520                 525             


Pro Gly Pro Ser Arg Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
    530                 535                 540                 


Leu Leu Trp Val Pro Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser 
545                 550                 555                 560 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                565                 570                 575     


Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Ile 
            580                 585                 590         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser 
        595                 600                 605             


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    610                 615                 620                 


Ser Phe Ile Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
625                 630                 635                 640 


Cys Gln His His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys 
                645                 650                 655     


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
        675                 680                 685             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
    690                 695                 700                 


Ser Arg Asn Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
705                 710                 715                 720 


Glu Trp Val Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala 
                725                 730                 735     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
            740                 745                 750         


Ser Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
        755                 760                 765             


Tyr Tyr Cys Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr Arg Phe Phe 
    770                 775                 780                 


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
785                 790                 795                 800 


Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro 
                805                 810                 815     


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
            820                 825                 830         


Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        835                 840                 845             


Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln 
    850                 855                 860                 


Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr 
865                 870                 875                 880 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                885                 890                 895     


Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly 
            900                 905                 910         


Gln Gly Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly 
        915                 920                 925             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr 
    930                 935                 940                 


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
945                 950                 955                 960 


Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
                965                 970                 975     


Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val 
            980                 985                 990         


Ala Ser Gly Val Pro Tyr Arg Phe  Ser Gly Ser Gly Ser  Gly Thr Ser 
        995                 1000                 1005             


Tyr Ser  Leu Thr Ile Ser Ser  Met Glu Ala Glu Asp  Ala Ala Thr 
    1010                 1015                 1020             


Tyr Tyr  Cys Gln Gln Trp Ser  Ser Asn Pro Leu Thr  Phe Gly Ala 
    1025                 1030                 1035             


Gly Thr  Lys Leu Glu Leu Lys  Thr Ser Gly Ser Gly  Glu Gly Arg 
    1040                 1045                 1050             


Gly Ser  Leu Leu Thr Cys Gly  Asp Val Glu Glu Asn  Pro Gly Pro 
    1055                 1060                 1065             


Arg Met  Val Ser Lys Gly Glu  Glu Asp Asn Met Ala  Ile Ile Lys 
    1070                 1075                 1080             


Glu Phe  Met Arg Phe Lys Val  His Met Glu Gly Ser  Val Asn Gly 
    1085                 1090                 1095             


His Glu  Phe Glu Ile Glu Gly  Glu Gly Glu Gly Arg  Pro Tyr Glu 
    1100                 1105                 1110             


Gly Thr  Gln Thr Ala Lys Leu  Lys Val Thr Lys Gly  Gly Pro Leu 
    1115                 1120                 1125             


Pro Phe  Ala Trp Asp Ile Leu  Ser Pro Gln Phe Met  Tyr Gly Ser 
    1130                 1135                 1140             


Lys Ala  Tyr Val Lys His Pro  Ala Asp Ile Pro Asp  Tyr Leu Lys 
    1145                 1150                 1155             


Leu Ser  Phe Pro Glu Gly Phe  Lys Trp Glu Arg Val  Met Asn Phe 
    1160                 1165                 1170             


Glu Asp  Gly Gly Val Val Thr  Val Thr Gln Asp Ser  Ser Leu Gln 
    1175                 1180                 1185             


Asp Gly  Glu Phe Ile Tyr Lys  Val Lys Leu Arg Gly  Thr Asn Phe 
    1190                 1195                 1200             


Pro Ser  Asp Gly Pro Val Met  Gln Lys Lys Thr Met  Gly Trp Glu 
    1205                 1210                 1215             


Ala Ser  Ser Glu Arg Met Tyr  Pro Glu Asp Gly Ala  Leu Lys Gly 
    1220                 1225                 1230             


Glu Ile  Lys Gln Arg Leu Lys  Leu Lys Asp Gly Gly  His Tyr Asp 
    1235                 1240                 1245             


Ala Glu  Val Lys Thr Thr Tyr  Lys Ala Lys Lys Pro  Val Gln Leu 
    1250                 1255                 1260             


Pro Gly  Ala Tyr Asn Val Asn  Ile Lys Leu Asp Ile  Thr Ser His 
    1265                 1270                 1275             


Asn Glu  Asp Tyr Thr Ile Val  Glu Gln Tyr Glu Arg  Ala Glu Gly 
    1280                 1285                 1290             


Arg His  Ser Thr Gly Gly Met  Asp Glu Leu Tyr Lys  
    1295                 1300                 1305 


<210>  180
<211>  3918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806BiTEHu08BiTE

<400>  180
atggaaacag atacattgtt gttgtgggta ctcctgctgt gggtccctgg gagcaccggt       60

gatattctga tgactcaatc tccgtcttct atgagcgtga gcttgggtga caccgtcagc      120

atcacctgtc attccagcca ggatataaac tcaaatatcg gctggctcca gcaacgccca      180

ggcaagtcat tcaaggggct tatttatcat ggcaccaatc ttgacgatga agtcccatca      240

cgcttcagcg gatcaggctc aggtgcggac tattccttga ctataagttc cctcgaatct      300

gaggatttcg ccgactatta ttgcgtacaa tacgcccagt ttccctggac cttcggaggc      360

ggcaccaaat tggagataaa aaggggtgga ggaggatcag gcgggggtgg aagcggcgga      420

ggaggcagcg acgtacaact gcaagaatcc gggccgagtt tggtcaagcc ctctcaatct      480

ctttctctca cttgcacggt caccggatac tccataacca gcgattttgc gtggaattgg      540

attcgacaat ttccagggaa taaattggaa tggatgggat atatcagtta ttctggtaat      600

accagataca acccgtcatt gaaaagtcgc atctctataa cacgagacac ttcaaagaat      660

cagttcttcc ttcagctcaa ttctgtaacc atcgaagata ctgctactta ttactgtgta      720

acggcgggtc gaggattccc ctactggggc cagggtacac tggttactgt ttccgccgga      780

ggaggaggaa gtgatattaa gctccagcaa tcaggggcag aattggcccg ccccggtgca      840

agcgtgaaaa tgtcctgcaa gactagcgga tacactttta ccagatacac gatgcactgg      900

gttaaacagc gaccggggca aggcttggag tggatcggat atattaaccc aagtcgcggc      960

tacacgaatt acaaccagaa attcaaagac aaggcaacac tgaccacaga taaatcatca     1020

tctaccgcgt atatgcaact gagttcactt actagcgagg attctgcggt atattactgt     1080

gcgcggtact acgacgacca ttactgtctg gactattggg gtcaaggcac cacccttact     1140

gtgagttcag tagaaggagg cagtgggggc tctggaggga gcggtggctc aggaggggta     1200

gacgacatcc aactgacgca atctccggct ataatgtcag cgtctccggg ggaaaaagta     1260

acgatgactt gtcgcgcgtc cagcagcgtc tcttatatga actggtatca acagaagagt     1320

gggacgagtc ctaagcgatg gatatatgat acaagcaaag ttgcgagcgg agtcccgtat     1380

cgcttctctg gaagtggcag cggaacctct tactccctca cgatcagcag catggaggcg     1440

gaggacgcag ccacctacta ctgtcagcag tggtcttcca accctctgac attcggagcc     1500

ggtacaaaac ttgaactgaa agttaacggc tccggcgcta caaactttag tctgctgaaa     1560

caggctggag atgtggagga aaaccccggc ccttctagaa tggaaacaga tacattgttg     1620

ttgtgggtac tcctgctgtg ggtccctggg agcaccggtg acatccaaat gactcagagc     1680

ccctctagcc tcagtgcaag cgtcggagac cgggtgacca tcacctgtaa agcgtcccag     1740

gatgttggaa cggcagtagc ttggtatcaa caaatcccag ggaaggctcc aaagctcctt     1800

atatactctg ctagttacag gtccaccggg gtgcccgacc gattctctgg ctccgggagc     1860

ggcactgact tttcattcat cattagtagt cttcaacctg aggactttgc cacctattat     1920

tgccagcacc actactctgc gccgtggact ttcggaggag gcacgaaggt tgaaattaaa     1980

ggtggaggtg ggtctggcgg aggtggaagt ggtggaggcg ggtccgaggt tcagttggta     2040

gagtcaggcg gtggtctggt gcagccaggt gggtccctgc gcctcagctg tgcagcttcc     2100

ggctttactt tctcaaggaa tggtatgtcc tgggtacggc aaacgccgga caaacgcctt     2160

gagtgggtag ctaccgtatc ctctgggggc tcttacatat actatgcaga ctctgtgaaa     2220

ggaagattta caatttcacg cgacaatgca aaaaatagtt tgtacctcca aatgtctagt     2280

cttagggccg aggatactgc cgtctactac tgtgcacgcc agggaacgac ggctcttgct     2340

acccgatttt tcgacgtttg gggccaagga acgttggtga cagttagcag tggagggggt     2400

gggtctgaca tcaagctgca acaaagtgga gccgaactcg cacggcccgg cgcgagcgtg     2460

aaaatgtcat gtaaaaccag tggttatacg tttacccgat acacgatgca ctgggtaaaa     2520

cagaggccgg ggcagggcct ggagtggatt ggctacatca atccttctcg cggctatacc     2580

aactataacc aaaaatttaa ggacaaagcc accttgacca ccgataagag cagctccact     2640

gcgtatatgc agctttcctc actcactagc gaagactcag cagtttatta ctgtgcaagg     2700

tattatgacg accactactg cctggactac tgggggcagg gcacaactct caccgtgtct     2760

tccgtagaag gggggagtgg tggatctggt ggcagcggag gttctggtgg agtggatgac     2820

atccaactga cacaaagccc agcaatcatg tccgcctcac ccggcgagaa ggttactatg     2880

acctgtcgcg ccagttctag cgtttcttac atgaactggt atcagcaaaa atctggtact     2940

tcccctaagc ggtggatcta cgacacgtct aaagttgcat ccggcgtccc gtacagattc     3000

agtggcagcg gtagtggcac tagctattcc ctcactataa gtagcatgga agccgaggat     3060

gccgcgactt actactgcca acagtggagt agtaatcccc ttactttcgg agccgggact     3120

aaactggagt tgaaaactag tggcagcgga gagggcagag gaagtcttct aacatgcggt     3180

gacgtggagg agaatcccgg ccctaggatg gtgagcaagg gcgaggagga taacatggcc     3240

atcatcaagg agttcatgcg cttcaaggtg cacatggagg gctccgtgaa cggccacgag     3300

ttcgagatcg agggcgaggg cgagggccgc ccctacgagg gcacccagac cgccaagctg     3360

aaggtgacca agggtggccc cctgcccttc gcctgggaca tcctgtcccc tcagttcatg     3420

tacggctcca aggcctacgt gaagcacccc gccgacatcc ccgactactt gaagctgtcc     3480

ttccccgagg gcttcaagtg ggagcgcgtg atgaacttcg aggacggcgg cgtggtgacc     3540

gtgacccagg actcctccct gcaggacggc gagttcatct acaaggtgaa gctgcgcggc     3600

accaacttcc cctccgacgg ccccgtaatg cagaagaaga ccatgggctg ggaggcctcc     3660

tccgagcgga tgtaccccga ggacggcgcc ctgaagggcg agatcaagca gaggctgaag     3720

ctgaaggacg gcggccacta cgacgctgag gtcaagacca cctacaaggc caagaagccc     3780

gtgcagctgc ccggcgccta caacgtcaac atcaagttgg acatcacctc ccacaacgag     3840

gactacacca tcgtggaaca gtacgaacgc gccgagggcc gccactccac cggcggcatg     3900

gacgagctgt acaagtaa                                                   3918


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  181

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  182
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  182

Asp Lys Thr His Thr 
1               5   


<210>  183
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  183

Cys Pro Pro Cys 
1               


<210>  184
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  184

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  185
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  185

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  186
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  186

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  187

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  188
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  188

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  189
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  189

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  190
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  190

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  191
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  191

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  192
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  192

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  193
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  193

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  194
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806 VH

<400>  194
gacgtacaac tgcaagaatc cgggccgagt ttggtcaagc cctctcaatc tctttctctc       60

acttgcacgg tcaccggata ctccataacc agcgattttg cgtggaattg gattcgacaa      120

tttccaggga ataaattgga atggatggga tatatcagtt attctggtaa taccagatac      180

aacccgtcat tgaaaagtcg catctctata acacgagaca cttcaaagaa tcagttcttc      240

cttcagctca attctgtaac catcgaagat actgctactt attactgtgt aacggcgggt      300

cgaggattcc cctactgggg ccagggtaca ctggttactg tttccgcc                   348


<210>  195
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806 VL

<400>  195
gatattctga tgactcaatc tccgtcttct atgagcgtga gcttgggtga caccgtcagc       60

atcacctgtc attccagcca ggatataaac tcaaatatcg gctggctcca gcaacgccca      120

ggcaagtcat tcaaggggct tatttatcat ggcaccaatc ttgacgatga agtcccatca      180

cgcttcagcg gatcaggctc aggtgcggac tattccttga ctataagttc cctcgaatct      240

gaggatttcg ccgactatta ttgcgtacaa tacgcccagt ttccctggac cttcggaggc      300

ggcaccaaat tggagataaa aagg                                             324


<210>  196
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  806BBZCAR

<400>  196
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccg atattctgat gactcaatct ccgtcttcta tgagcgtgag cttgggtgac      120

accgtcagca tcacctgtca ttccagccag gatataaact caaatatcgg ctggctccag      180

caacgcccag gcaagtcatt caaggggctt atttatcatg gcaccaatct tgacgatgaa      240

gtcccatcac gcttcagcgg atcaggctca ggtgcggact attccttgac tataagttcc      300

ctcgaatctg aggatttcgc cgactattat tgcgtacaat acgcccagtt tccctggacc      360

ttcggaggcg gcaccaaatt ggagataaaa aggggtggag gaggatcagg cgggggtgga      420

agcggcggag gaggcagcga cgtacaactg caagaatccg ggccgagttt ggtcaagccc      480

tctcaatctc tttctctcac ttgcacggtc accggatact ccataaccag cgattttgcg      540

tggaattgga ttcgacaatt tccagggaat aaattggaat ggatgggata tatcagttat      600

tctggtaata ccagatacaa cccgtcattg aaaagtcgca tctctataac acgagacact      660

tcaaagaatc agttcttcct tcagctcaat tctgtaacca tcgaagatac tgctacttat      720

tactgtgtaa cggcgggtcg aggattcccc tactggggcc agggtacact ggttactgtt      780

tccgcctccg gaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210>  197
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  806BBZCAR

<400>  197

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Leu Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Met Ser Val Ser Leu Gly Asp Thr Val Ser Ile Thr Cys His Ser 
        35                  40                  45              


Ser Gln Asp Ile Asn Ser Asn Ile Gly Trp Leu Gln Gln Arg Pro Gly 
    50                  55                  60                  


Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr Asn Leu Asp Asp Glu 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val 
            100                 105                 110         


Gln Tyr Ala Gln Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
                165                 170                 175     


Ser Asp Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
            180                 185                 190         


Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr Arg Tyr Asn Pro 
        195                 200                 205             


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
    210                 215                 220                 


Phe Phe Leu Gln Leu Asn Ser Val Thr Ile Glu Asp Thr Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ala Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  198
<211>  139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  inducible promoter

<400>  198
cccgatgttt tctgagttac ttttgtatcc ccaccccccc tcgaggagga aaaactgttt       60

catacagaag gcgtacgcct tctgtatgaa acagtttttc ctccacgcct tctgtatgaa      120

acagtttttc ctccacgtg                                                   139


