                         SEQUENCE LISTING

<110>  GENOME PROTECTION, INC.
       Gudkov, Andrei
       Andrianova, Ekaterina
 
<120>  METHODS OF INCREASING VACCINE EFFICACY

<130>  GPI-004PC/122460-5004

<150>  US 62/894,355
<151>  2019-08-30

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  1

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln 
        35                  40                  45              


Asn Asn Leu Asn Lys Ser Gln Ser Ser Leu Ser Ser Ala Ile Glu Arg 
    50                  55                  60                  


Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln 
                85                  90                  95      


Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu 
            100                 105                 110         


Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu 
        115                 120                 125             


Ser Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser 
    130                 135                 140                 


Ile Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser 
145                 150                 155                 160 


Asn Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln 
                165                 170                 175     


Met Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp 
            180                 185                 190         


Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val 
        195                 200                 205             


Asn Ser Pro Gly Ile Ser Gly Gly Gly Gly Gly Ile Leu Asp Ser Met 
    210                 215                 220                 


Gly Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala 
225                 230                 235                 240 


Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val 
                245                 250                 255     


Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr 
            260                 265                 270         


Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile 
        275                 280                 285             


Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Lys Ala Gln 
    290                 295                 300                 


Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val 
305                 310                 315                 320 


Pro Gln Asn Val Leu Ser Leu Leu Arg 
                325                 


<210>  2
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  2

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser Ile 
65                  70                  75                  80  


Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Asn 
                85                  90                  95      


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln Met 
            100                 105                 110         


Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ile Ser Gly Gly Gly Gly Gly Ile Leu Asp Ser Met Gly 
145                 150                 155                 160 


Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala Asn 
                165                 170                 175     


Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg 
            180                 185                 190         


Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn 
        195                 200                 205             


Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu 
    210                 215                 220                 


Asp Ala Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Lys Ala Gln Ile 
225                 230                 235                 240 


Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro 
                245                 250                 255     


Gln Asn Val Leu Ser Leu Leu Val Pro Arg Gly Ser His His His His 
            260                 265                 270         


His His Gly 
        275 


<210>  3
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  3

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser Ile 
65                  70                  75                  80  


Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Asn 
                85                  90                  95      


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln Met 
            100                 105                 110         


Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Asn Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Leu Val Pro Arg 
    210                 215                 220                 


Gly Ser His His His His His His Gly 
225                 230             


<210>  4
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  4

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  5
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  5

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Leu Val Pro Arg Gly 
            20                  25                  30          


Ser Ala Lys Asp Pro Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp 
        35                  40                  45              


Ala Ala Gly Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly 
    50                  55                  60                  


Leu Thr Gln Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln 
65                  70                  75                  80  


Thr Thr Glu Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val 
                85                  90                  95      


Arg Glu Leu Ser Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp 
            100                 105                 110         


Leu Lys Ser Ile Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp 
        115                 120                 125             


Arg Val Ser Asn Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln 
    130                 135                 140                 


Asp Asn Gln Met Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile 
145                 150                 155                 160 


Thr Ile Asp Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly 
                165                 170                 175     


Phe Asn Val Asn Ser Pro Gly Ile Ser Gly Gly Gly Gly Gly Ile Leu 
            180                 185                 190         


Asp Ser Met Gly Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys 
        195                 200                 205             


Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val 
    210                 215                 220                 


Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser 
225                 230                 235                 240 


Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg 
                245                 250                 255     


Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Asn Met Ser 
            260                 265                 270         


Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala 
        275                 280                 285             


Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
    290                 295                 300 


<210>  6
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  6

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser Ile 
65                  70                  75                  80  


Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Asn 
                85                  90                  95      


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln Met 
            100                 105                 110         


Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Asn Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
    210                 215                 220                 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Val Pro 
225                 230                 235                 240 


Arg Gly Ser His His His His His His Gly 
                245                 250 


<210>  7
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  7

Met Gly His His His His His His Ser Gly Met Glu Glu Phe Asn Met 
1               5                   10                  15      


Arg Ile Asn Thr Asn Val Ala Ala Met Asn Thr Tyr Ser Arg Leu Thr 
            20                  25                  30          


Ala Ala Asn Thr Ala Lys Ser Asn Ser Leu Ala Lys Leu Ser Ser Gly 
        35                  40                  45              


Leu Arg Ile Asn Lys Ala Gly Asp Asp Ala Ala Gly Leu Ala Ile Ser 
    50                  55                  60                  


Glu Lys Met Lys Ser Gln Ile Gly Gly Leu Thr Gln Ala Lys Arg Asn 
65                  70                  75                  80  


Ala Gln Asp Gly Ile Ser Leu Val Gln Thr Ala Glu Gly Ala Leu Asn 
                85                  90                  95      


Glu Thr His Ser Ile Leu Glu Arg Met Arg Asp Leu Ala Val Gln Gly 
            100                 105                 110         


Ser Asn Gly Thr Leu Thr Ser Ser Asp Arg Gly Ser Ile Asn Lys Glu 
        115                 120                 125             


Leu Lys Ala Leu His Gln Glu Leu Thr Arg Ile Ser Asn Thr Thr Glu 
    130                 135                 140                 


Phe Asn Thr Gln Lys Leu Phe Ser Gln Thr Lys Gln Lys Ser Val Thr 
145                 150                 155                 160 


Phe Thr Phe Gln Ile Gly Ala Asn Ala Gly Gln Thr Leu Ser Val Ala 
                165                 170                 175     


Ile Thr Ala Met Ser Gly Glu Ala Leu Leu Val Ser Thr Asp Ala Lys 
            180                 185                 190         


Phe Ser Leu Asn Ala Ala Gly Thr Asn Ala Gly Ala Met Ile Lys Ser 
        195                 200                 205             


Ile Asp Ala Ala Ile Ala Lys Val Ser Asp Gln Arg Ala Asp Leu Gly 
    210                 215                 220                 


Ala Val Gln Asn Arg Leu Glu His Thr Ile Asn Asn Leu Thr Ala Thr 
225                 230                 235                 240 


Asn Glu Asn Leu Ser Asp Ala Asn Ser Arg Ile Arg Asp Val Asp Met 
                245                 250                 255     


Ala Glu Glu Met Met Thr Phe Thr Lys Ser Asn Ile Leu Ser Gln Ala 
            260                 265                 270         


Ala Thr Ser Met Leu Ala Gln Ala Asn Ala Met Pro Asn Ser Val Leu 
        275                 280                 285             


Asn Leu Leu Gln Gly 
    290             


<210>  8
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  8

Met Gly His His His His His His Ser Gly Met Arg Ile Asn His Asn 
1               5                   10                  15      


Ile Ser Ala Leu Asn Ala Trp Arg Asn Ile Asp Gln Thr Gln Tyr Ser 
            20                  25                  30          


Met Ser Lys Thr Leu Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Arg 
        35                  40                  45              


Ala Gly Asp Asp Ala Ala Gly Leu Ala Ile Ser Glu Lys Met Arg Gly 
    50                  55                  60                  


Gln Ile Lys Gly Leu Asn Met Ala Ile Lys Asn Ala Gln Asp Ala Ile 
65                  70                  75                  80  


Ser Leu Ile Gln Thr Ala Glu Gly Ala Leu Thr Glu Val His Ser Ile 
                85                  90                  95      


Leu Gln Arg Met Arg Glu Leu Ala Val Gln Ala Ala Ser Asp Thr Asn 
            100                 105                 110         


Thr Asn Val Asp Arg Glu Gln Ile Gln Lys Glu Ile Asp Gln Leu Arg 
        115                 120                 125             


Glu Glu Ile Asp Arg Ile Ala Arg Thr Thr Glu Phe Asn Thr Lys Lys 
    130                 135                 140                 


Leu Leu Asp Gly Lys Leu Glu Gly Phe Arg Ser Gln Val Asp Ala Lys 
145                 150                 155                 160 


Val Val Thr Gly Gly Asn Ile Asn Val Gln Leu Gly Thr Val Ser Ser 
                165                 170                 175     


Lys Ala Val Glu Gly Thr Tyr Val Ile Glu Val Gly Ala Ala Glu Arg 
            180                 185                 190         


Ala Ile Met Val Val Asp Ala Ala Ile His Arg Val Ser Thr Ala Arg 
        195                 200                 205             


Ala Ala Leu Gly Ala Ile Gln Asn Arg Leu Glu His Thr Ile Ser Asn 
    210                 215                 220                 


Leu Gly Val Ala Ala Glu Asn Leu Thr Ala Ala Glu Ser Arg Ile Arg 
225                 230                 235                 240 


Asp Ala Asp Met Ala Lys Glu Met Met Glu Phe Thr Lys Gln Gln Ile 
                245                 250                 255     


Leu Leu Gln Ser Ser Met Ala Met Leu Ala Gln Ser Asn Thr Leu Pro 
            260                 265                 270         


Gln Asn Val Leu Gln Leu Met Arg 
        275                 280 


<210>  9
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  9

Met Gly His His His His His His Ser Gly Leu Asn Met Ala Ile Lys 
1               5                   10                  15      


Asn Ala Gln Asp Ala Ile Ser Leu Ile Gln Thr Ala Glu Gly Ala Leu 
            20                  25                  30          


Thr Glu Val His Ser Ile Leu Gln Arg Met Arg Glu Leu Ala Val Gln 
        35                  40                  45              


Ala Ala Ser Asp Thr Asn Thr Asn Val Asp Arg Glu Gln Ile Gln Lys 
    50                  55                  60                  


Glu Ile Asp Gln Leu Arg Glu Glu Ile Asp Arg Ile Ala Arg Thr Thr 
65                  70                  75                  80  


Glu Phe Asn Thr Lys Lys Leu Leu Asp Gly Lys Leu Glu Gly Phe Arg 
                85                  90                  95      


Ser Gln Val Asp Ala Lys Val Val Thr Gly Gly Asn Ile Asn Val Gln 
            100                 105                 110         


Leu Gly Thr Val Ser Ser Lys Ala Val Glu Gly Thr Tyr Val Ile Glu 
        115                 120                 125             


Val Gly Ala Ala Glu Arg Ala Ile Met Val Val Asp Ala Ala Ile His 
    130                 135                 140                 


Arg Val Ser Thr Ala Arg Ala Ala Leu Gly Ala Ile Gln Asn Arg Leu 
145                 150                 155                 160 


Glu His Thr Ile Ser Asn Leu Gly 
                165             


<210>  10
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  10

Met Gly His His His His His His Ser Gly Met Ser Leu Arg Ile Asn 
1               5                   10                  15      


Asn Asn Ile Glu Ala Leu Asn Ala Trp Arg Ala Leu Asn Ser Thr Ser 
            20                  25                  30          


Asn Ala Leu Gln Lys Ser Met Glu Lys Leu Ser Ser Gly Leu Arg Ile 
        35                  40                  45              


Asn Arg Ala Gly Asp Asp Ala Ala Gly Leu Ala Ile Ser Glu Lys Leu 
    50                  55                  60                  


Arg Ala Gln Ile Arg Gly Leu Asn Gln Ala Ile Arg Asn Ala Gln Asp 
65                  70                  75                  80  


Gly Ile Ser Leu Ile Gln Thr Ala Glu Gly Gly Leu Ser Glu Ile Gln 
                85                  90                  95      


Asn Ile Leu Gln Arg Met Arg Glu Leu Gly Val Gln Ala Ala Asn Gly 
            100                 105                 110         


Thr Leu Asn Asn Gln Asp Ile Ser Ala Ile Thr Thr Glu Leu Asn Gln 
        115                 120                 125             


Leu Phe Asn Glu Ile Asp Arg Ile Ala Gly Ala Thr Glu Phe Asn Thr 
    130                 135                 140                 


Lys Asn Leu Leu Ala Val Ser Thr Gly Leu Val Val Thr Leu Gln Val 
145                 150                 155                 160 


Gly Ala Asn Ala Gly Gln Val Ile Ala Phe Thr Ile Asp Asn Ala Gly 
                165                 170                 175     


Thr Ala Ser Leu Gly Leu Ser Ser Ala Asp Leu Ala Ile Asn Asp Asn 
            180                 185                 190         


Ala Ser Ala Ser Ala Phe Ile Ser Lys Val Asp Ser Ala Leu Gln Lys 
        195                 200                 205             


Val Ser Thr Tyr Arg Ala Asn Leu Gly Ser Ile Gln Asn Arg Leu Glu 
    210                 215                 220                 


His Thr Ile Ala Asn Leu Gly Ile Ala Ser Glu Asn Leu Ser Ala Ser 
225                 230                 235                 240 


Glu Ser Arg Ile Arg Asp Val Asp Met Ala Ala Glu Met Met Asn Phe 
                245                 250                 255     


Thr Lys Asn Gln Ile Leu Gln Gln Ala Gly Val Ala Ile Leu Ala Gln 
            260                 265                 270         


Ala Asn Gln Ala Pro Gln Ala Val Leu Gln Leu Leu Arg 
        275                 280                 285 


<210>  11
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  11

Met Gly His His His His His His Ser Gly Leu Asn Gln Ala Ile Arg 
1               5                   10                  15      


Asn Ala Gln Asp Gly Ile Ser Leu Ile Gln Thr Ala Glu Gly Gly Leu 
            20                  25                  30          


Ser Glu Ile Gln Asn Ile Leu Gln Arg Met Arg Glu Leu Gly Val Gln 
        35                  40                  45              


Ala Ala Asn Gly Thr Leu Asn Asn Gln Asp Ile Ser Ala Ile Thr Thr 
    50                  55                  60                  


Glu Leu Asn Gln Leu Phe Asn Glu Ile Asp Arg Ile Ala Gly Ala Thr 
65                  70                  75                  80  


Glu Phe Asn Thr Lys Asn Leu Leu Ala Val Ser Thr Gly Leu Val Val 
                85                  90                  95      


Thr Leu Gln Val Gly Ala Asn Ala Gly Gln Val Ile Ala Phe Thr Ile 
            100                 105                 110         


Asp Asn Ala Gly Thr Ala Ser Leu Gly Leu Ser Ser Ala Asp Leu Ala 
        115                 120                 125             


Ile Asn Asp Asn Ala Ser Ala Ser Ala Phe Ile Ser Lys Val Asp Ser 
    130                 135                 140                 


Ala Leu Gln Lys Val Ser Thr Tyr Arg Ala Asn Leu Gly Ser Ile Gln 
145                 150                 155                 160 


Asn Arg Leu Glu His Thr Ile Ala Asn Leu Gly 
                165                 170     


<210>  12
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  12

Met Gly His His His His His His Ser Gly Leu Asn Gln Ala Ile Arg 
1               5                   10                  15      


Asn Ala Gln Asp Gly Ile Ser Leu Ile Gln Thr Ala Glu Gly Gly Leu 
            20                  25                  30          


Ser Glu Ile Gln Asn Ile Leu Gln Arg Met Arg Glu Leu Gly Val Gln 
        35                  40                  45              


Ala Ala Asn Gly Thr Leu Asn Asn Gln Asp Ile Ser Ala Ile Thr Thr 
    50                  55                  60                  


Glu Leu Asn Gln Leu Phe Asn Glu Ile Asp Arg Ile Ala Gly Ala Thr 
65                  70                  75                  80  


Glu Phe Asn Thr Lys Asn Leu Leu Ala Ala Gly Thr Ala Ser Leu Gly 
                85                  90                  95      


Leu Ser Ser Ala Asp Leu Ala Ile Asn Asp Asn Ala Ser Ala Ser Ala 
            100                 105                 110         


Phe Ile Ser Lys Val Asp Ser Ala Leu Gln Lys Val Ser Thr Tyr Arg 
        115                 120                 125             


Ala Asn Leu Gly Ser Ile Gln Asn Arg Leu Glu His Thr Ile Ala Asn 
    130                 135                 140                 


Leu Gly 
145     


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  13

Met Gly His His His His His His Ser Ala Ser Ala Phe Ile Ser Lys 
1               5                   10                  15      


Val Asp Ser Ala Leu Gln Lys Val Ser Thr Tyr Arg Ala Asn Leu Gly 
            20                  25                  30          


Ser Ile Gln Asn Arg Leu Glu His Thr Ile Ala Asn Leu Gly Pro Asp 
        35                  40                  45              


Gly Leu Asn Gln Ala Ile Arg Asn Ala Gln Asp Gly Ile Ser Leu Ile 
    50                  55                  60                  


Gln Thr Ala Glu Gly Gly Leu Ser Glu Ile Gln Asn Ile Leu Gln Arg 
65                  70                  75                  80  


Met Arg Glu Leu Gly Val Gln Ala Ala Asn Gly Thr Leu Asn Asn Gln 
                85                  90                  95      


Asp Ile Ser Ala Ile Thr Thr Glu Leu Asn Gln Leu Phe Asn Glu Ile 
            100                 105                 110         


Asp Arg Ile Ala 
        115     


<210>  14
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  14

Met Gly His His His His His His Ser Asn Asn Gln Asp Ile Ser Ala 
1               5                   10                  15      


Ile Thr Thr Glu Leu Asn Gln Leu Phe Asn Glu Ile Asp Arg Ile Ala 
            20                  25                  30          


Gly Ala Thr Gly Ser Gly Gly Leu Ser Glu Ile Gln Asn Ile Leu Gln 
        35                  40                  45              


Arg Met Arg Glu Leu Gly Val Gln Ala Ala Asn Gly Thr Leu Asn Gly 
    50                  55                  60                  


Gly Ser Ala Ser Ala Phe Ile Ser Lys Val Asp Ser Ala Leu Gln Lys 
65                  70                  75                  80  


Val Ser Thr Tyr Arg Ala Asn Leu Gly Ser Ile Gln Asn Arg Leu Glu 
                85                  90                  95      


His Thr Ile Ala Asn Leu Gly 
            100             


<210>  15
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  15

Met Gly His His His His His His Ser Gly Leu Ala Gln Ala Ser Arg 
1               5                   10                  15      


Asn Ala Gln Asp Ala Ile Ser Ile Ala Gln Thr Ala Glu Gly Ala Leu 
            20                  25                  30          


Asp Glu Thr Gln Ser Ile Leu Gln Arg Val Arg Glu Leu Gly Val Gln 
        35                  40                  45              


Gly Ala Asn Gly Thr Leu Thr Ala Asp Asp Ile Asn Ala Leu Gln Ala 
    50                  55                  60                  


Glu Val Asp Gln Leu Ile Ala Glu Ile Asp Arg Ile Ala Gly Ala Thr 
65                  70                  75                  80  


Glu Phe Asn Thr Gln Asn Leu Leu Asp Gly Ser Phe Thr Thr Lys Ala 
                85                  90                  95      


Phe Gln Val Gly Ala Asn Ser Gly Gln Asn Met Thr Leu Thr Ile Gly 
            100                 105                 110         


Lys Met Asp Thr Thr Thr Leu Gly Leu Ser Ser Ala Asp Leu Ala Ile 
        115                 120                 125             


Asn Asp Asn Ala Phe Ala Asn Gly Ala Ile Ser Thr Val Asp Ser Ala 
    130                 135                 140                 


Leu Gln Lys Val Ser Ala Glu Arg Ala Lys Leu Gly Ala Ile Gln Asn 
145                 150                 155                 160 


Arg Leu Glu His Thr Ile Ala Asn Leu Gly 
                165                 170 


<210>  16
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  16

Met Gly His His His His His His Ser Gly Leu Ala Gln Ala Ser Arg 
1               5                   10                  15      


Gln Ala Gln Asp Ala Ile Ser Ile Ala Gln Thr Ala Glu Gly Ala Leu 
            20                  25                  30          


Asp Glu Thr Gln Ser Ile Leu Gln Arg Val Arg Glu Leu Gly Val Gln 
        35                  40                  45              


Gly Ala Asp Gly Thr Leu Thr Ala Asp Asp Ile Asp Ala Leu Gln Ala 
    50                  55                  60                  


Glu Val Asp Gln Leu Ile Ala Glu Ile Asp Arg Ile Ala Gly Ala Thr 
65                  70                  75                  80  


Glu Phe Ala Thr Gln Lys Leu Leu Asp Gly Ser Phe Thr Thr Lys Ala 
                85                  90                  95      


Phe Gln Val Gly Ala Ala Ser Gly Gln Asp Val Thr Leu Thr Ile Gly 
            100                 105                 110         


Lys Val Asp Thr Thr Thr Leu Gly Leu Ser Ser Ala Asp Leu Ala Ile 
        115                 120                 125             


Asp Ser Ala Ala Phe Ala Asp Gly Ala Ile Ser Thr Val Asp Ser Ala 
    130                 135                 140                 


Leu Gln Lys Val Ser Ala Glu Arg Ala Lys Leu Gly Ala Ile Gln Asn 
145                 150                 155                 160 


Arg Leu Glu His Thr Ile Ala Gln Leu Gly 
                165                 170 


<210>  17
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  17

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln 
        35                  40                  45              


Asn Asn Leu Asn Lys Ser Gln Ser Ser Leu Ser Ser Ala Ile Glu Arg 
    50                  55                  60                  


Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln 
                85                  90                  95      


Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu 
            100                 105                 110         


Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu 
        115                 120                 125             


Ser Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser 
    130                 135                 140                 


Ile Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser 
145                 150                 155                 160 


Asn Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln 
                165                 170                 175     


Met Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp 
            180                 185                 190         


Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val 
        195                 200                 205             


Asn Ser Pro Gly Ile Ser Gly Gly Gly Gly Gly Ile Leu Asp Ser Met 
    210                 215                 220                 


Gly Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala 
225                 230                 235                 240 


Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val 
                245                 250                 255     


Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr 
            260                 265                 270         


Asn Leu 
        


<210>  18
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  18

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala 
        35                  40                  45              


Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu 
    50                  55                  60                  


Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser Val Gln Ala Thr 
65                  70                  75                  80  


Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser Ile Gln Asp Glu Ile 
                85                  90                  95      


Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Asn Gln Thr Gln Phe 
            100                 105                 110         


Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln Met Lys Ile Gln Val 
        115                 120                 125             


Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp Leu Gln Lys Ile Asp 
    130                 135                 140                 


Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn Ser Pro Gly Ile 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Gly Ile Leu Asp Ser Met Gly Thr Leu Ile Asn 
                165                 170                 175     


Glu Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala Asn Pro Leu Ala Ser 
            180                 185                 190         


Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly 
        195                 200                 205             


Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr 
    210                 215                 220                 


Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr 
225                 230                 235                 240 


Ala Thr Glu Val Ser Asn Met Ser Lys Ala Gln Ile Leu Gln Gln Ala 
                245                 250                 255     


Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu 
            260                 265                 270         


Ser Leu Leu Arg 
        275     


<210>  19
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  19

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln 
        35                  40                  45              


Asn Asn Leu Asn Lys Ser Gln Ser Ser Leu Ser Ser Ala Ile Glu Arg 
    50                  55                  60                  


Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln 
                85                  90                  95      


Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu 
            100                 105                 110         


Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu 
        115                 120                 125             


Ser Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser 
    130                 135                 140                 


Ile Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser 
145                 150                 155                 160 


Asn Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln 
                165                 170                 175     


Met Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp 
            180                 185                 190         


Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Ile Pro Gly Ile Ser 
        195                 200                 205             


Gly Gly Gly Gly Gly Ile Leu Asp Ser Met Gly Thr Leu Ile Asn Glu 
    210                 215                 220                 


Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala Asn Pro Leu Ala Ser Ile 
225                 230                 235                 240 


Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala 
                245                 250                 255     


Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val 
            260                 265                 270         


Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala 
        275                 280                 285             


Thr Glu Val Ser Asn Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly 
    290                 295                 300                 


Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser 
305                 310                 315                 320 


Leu Leu Arg 
            


<210>  20
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  20

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala 
        35                  40                  45              


Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu 
    50                  55                  60                  


Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser Val Gln Ala Thr 
65                  70                  75                  80  


Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser Ile Gln Asp Glu Ile 
                85                  90                  95      


Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Asn Gln Thr Gln Phe 
            100                 105                 110         


Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln Met Lys Ile Gln Val 
        115                 120                 125             


Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp Leu Gln Lys Ile Asp 
    130                 135                 140                 


Val Lys Ser Leu Gly Leu Ile Pro Gly Ile Ser Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Ile Leu Asp Ser Met Gly Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala 
                165                 170                 175     


Lys Lys Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser 
            180                 185                 190         


Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe 
        195                 200                 205             


Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser 
    210                 215                 220                 


Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Asn 
225                 230                 235                 240 


Met Ser Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala 
                245                 250                 255     


Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
            260                 265                 270 


<210>  21
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  21

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln 
        35                  40                  45              


Asn Asn Leu Asn Lys Ser Gln Ser Ser Leu Ser Ser Ala Ile Glu Arg 
    50                  55                  60                  


Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln 
                85                  90                  95      


Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu 
            100                 105                 110         


Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu 
        115                 120                 125             


Ser Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser 
    130                 135                 140                 


Ile Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser 
145                 150                 155                 160 


Asn Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln 
                165                 170                 175     


Met Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp 
            180                 185                 190         


Leu Gln Lys Ile Ile Pro Gly Ile Ser Gly Gly Gly Gly Gly Ile Leu 
        195                 200                 205             


Asp Ser Met Gly Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys 
    210                 215                 220                 


Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val 
225                 230                 235                 240 


Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser 
                245                 250                 255     


Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg 
            260                 265                 270         


Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Asn Met Ser 
        275                 280                 285             


Lys Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala 
    290                 295                 300                 


Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
305                 310                 315     


<210>  22
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  22

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala 
        35                  40                  45              


Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu 
    50                  55                  60                  


Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser Val Gln Ala Thr 
65                  70                  75                  80  


Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser Ile Gln Asp Glu Ile 
                85                  90                  95      


Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Asn Gln Thr Gln Phe 
            100                 105                 110         


Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln Met Lys Ile Gln Val 
        115                 120                 125             


Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp Leu Gln Lys Ile Ile 
    130                 135                 140                 


Pro Gly Ile Ser Gly Gly Gly Gly Gly Ile Leu Asp Ser Met Gly Thr 
145                 150                 155                 160 


Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala Asn Pro 
                165                 170                 175     


Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser 
            180                 185                 190         


Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu 
        195                 200                 205             


Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp 
    210                 215                 220                 


Ala Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Lys Ala Gln Ile Leu 
225                 230                 235                 240 


Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln 
                245                 250                 255     


Asn Val Leu Ser Leu Leu Arg 
            260             


<210>  23
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  23

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln 
        35                  40                  45              


Asn Asn Leu Asn Lys Ser Gln Ser Ser Leu Ser Ser Ala Ile Glu Arg 
    50                  55                  60                  


Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln 
                85                  90                  95      


Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu 
            100                 105                 110         


Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu 
        115                 120                 125             


Ser Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser 
    130                 135                 140                 


Ile Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser 
145                 150                 155                 160 


Asn Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln 
                165                 170                 175     


Met Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp 
            180                 185                 190         


Leu Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Ile Pro Gly Ile Ser 
        195                 200                 205             


Gly Gly Gly Gly Gly Ile Leu Asp Ser Met Gly Thr Leu Ile Asn Glu 
    210                 215                 220                 


Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala Asn Pro Leu Ala Ser Ile 
225                 230                 235                 240 


Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala 
                245                 250                 255     


Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu 
            260                 265             


<210>  24
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  24

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln 
        35                  40                  45              


Asn Asn Leu Asn Lys Ser Gln Ser Ser Leu Ser Ser Ala Ile Glu Arg 
    50                  55                  60                  


Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln 
                85                  90                  95      


Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu 
            100                 105                 110         


Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu 
        115                 120                 125             


Ser Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser 
    130                 135                 140                 


Ile Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser 
145                 150                 155                 160 


Asn Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln 
                165                 170                 175     


Met Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp 
            180                 185                 190         


Leu Gln Lys Ile Ile Pro Gly Ile Ser Gly Gly Gly Gly Gly Ile Leu 
        195                 200                 205             


Asp Ser Met Gly Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys 
    210                 215                 220                 


Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val 
225                 230                 235                 240 


Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser 
                245                 250                 255     


Ala Ile Thr Asn Leu 
            260     


<210>  25
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  25

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln 
        35                  40                  45              


Asn Asn Leu Asn Lys Ser Gln Ser Ser Leu Ser Ser Ala Ile Glu Arg 
    50                  55                  60                  


Leu Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln 
                85                  90                  95      


Ala Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu 
            100                 105                 110         


Gly Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu 
        115                 120                 125             


Ser Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser 
    130                 135                 140                 


Ile Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser 
145                 150                 155                 160 


Asn Gln Ile Pro Gly Ile Ser Gly Gly Gly Gly Gly Ile Leu Asp Ser 
                165                 170                 175     


Met Gly Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys Ser Thr 
            180                 185                 190         


Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala 
        195                 200                 205             


Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile 
    210                 215                 220                 


Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg 
225                 230                 235                 240 


Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Lys Ala 
                245                 250                 255     


Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln 
            260                 265                 270         


Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
        275                 280         


<210>  26
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  26

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Pro Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala Ser Arg Asn Ala 
        35                  40                  45              


Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly Ala Leu Asn Glu 
    50                  55                  60                  


Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser Val Gln Ala Thr 
65                  70                  75                  80  


Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser Ile Gln Asp Glu Ile 
                85                  90                  95      


Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Asn Gln Ile Pro Gly 
            100                 105                 110         


Ile Ser Gly Gly Gly Gly Gly Ile Leu Asp Ser Met Gly Thr Leu Ile 
        115                 120                 125             


Asn Glu Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala Asn Pro Leu Ala 
    130                 135                 140                 


Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val Arg Ser Ser Leu 
145                 150                 155                 160 


Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn 
                165                 170                 175     


Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp 
            180                 185                 190         


Tyr Ala Thr Glu Val Ser Asn Met Ser Lys Ala Gln Ile Leu Gln Gln 
        195                 200                 205             


Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val Pro Gln Asn Val 
    210                 215                 220                 


Leu Ser Leu Leu Arg 
225                 


<210>  27
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  27

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ser Leu Ser Ser Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
                85                  90                  95      


Val Gln Ala Thr Asn Gly Thr Asn Ser Asp Ser Asp Leu Lys Ser Ile 
            100                 105                 110         


Gln Asp Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Asn 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ser Gln Asp Asn Gln Met 
    130                 135                 140                 


Lys Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Thr Ile Asp Leu 
145                 150                 155                 160 


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
                165                 170                 175     


Gly Pro Lys Glu Ala Thr Val Gly Asp Leu Lys Ser Ser Phe Lys Asn 
            180                 185                 190         


Val Thr Gly Tyr Asp Thr Tyr Ala Ala Gly Ala Asp Lys Tyr Arg Val 
        195                 200                 205             


Asp Ile Asn Ser Gly Ala Val Val Thr Asp Ala Ala Ala Pro Asp Lys 
    210                 215                 220                 


Val Tyr Val Asn Ala Ala Asn Gly Gln Leu Thr Thr Asp Asp Ala Glu 
225                 230                 235                 240 


Asn Asn Thr Ala Val Asp Leu Phe Lys Thr Thr Lys Ser Thr Ala Gly 
                245                 250                 255     


Thr Ala Glu Ala Lys Ala Ile Ala Gly Ala Ile Lys Gly Gly Lys Glu 
            260                 265                 270         


Gly Asp Thr Phe Asp Tyr Lys Gly Val Thr Phe Thr Ile Asp Thr Lys 
        275                 280                 285             


Thr Gly Asp Asp Gly Asn Gly Lys Val Ser Thr Thr Ile Asn Gly Glu 
    290                 295                 300                 


Lys Val Thr Leu Thr Val Ala Asp Ile Ala Thr Gly Ala Ala Asp Val 
305                 310                 315                 320 


Asn Ala Ala Thr Leu Gln Ser Ser Lys Asn Val Tyr Thr Ser Val Val 
                325                 330                 335     


Asn Gly Gln Phe Thr Phe Asp Asp Lys Thr Lys Asn Glu Ser Ala Lys 
            340                 345                 350         


Leu Ser Asp Leu Glu Ala Asn Asn Ala Val Lys Gly Glu Ser Lys Ile 
        355                 360                 365             


Thr Val Asn Gly Ala Glu Tyr Thr Ala Asn Ala Thr Gly Asp Lys Ile 
    370                 375                 380                 


Thr Leu Ala Gly Lys Thr Met Phe Ile Asp Lys Thr Ala Ser Gly Val 
385                 390                 395                 400 


Ser Thr Leu Ile Asn Glu Asp Ala Ala Ala Ala Lys Lys Ser Thr Ala 
                405                 410                 415     


Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu Ser Lys Val Asp Ala Val 
            420                 425                 430         


Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg Phe Asp Ser Ala Ile Thr 
        435                 440                 445             


Asn Leu Gly Asn Thr Val Thr Asn Leu Asn Ser Ala Arg Ser Arg Ile 
    450                 455                 460                 


Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser Asn Met Ser Lys Ala Gln 
465                 470                 475                 480 


Ile Leu Gln Gln Ala Gly Thr Ser Val Leu Ala Gln Ala Asn Gln Val 
                485                 490                 495     


Pro Gln Asn Val Leu Ser Leu Leu Arg 
            500                 505 


<210>  28
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polymer.

<400>  28

Met Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
1               5                   10                  15      


Ala Ala Ala Asn Arg Ala Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
            20                  25                  30          


Ser Arg Asn Ala Ala Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
        35                  40                  45              


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ser 
    50                  55                  60                  


Val Gln Ala Thr Ala Gly Ala Asn Ala Asp Ala Ala Leu Lys Ala Ile 
65                  70                  75                  80  


Gln Ala Glu Ile Gln Gln Arg Leu Glu Glu Ile Asp Arg Val Ser Gln 
                85                  90                  95      


Gln Thr Gln Ala Ala Ala Val Lys Val Leu Ser Gln Asp Asn Ala Met 
            100                 105                 110         


Ala Ile Gln Val Gly Ala Asn Asp Gly Ala Ala Ile Thr Ile Asp Leu 
        115                 120                 125             


Gln Lys Ile Asp Val Lys Ser Leu Gly Leu Asp Gly Phe Asn Val Asn 
    130                 135                 140                 


Ser Pro Gly Ser Thr Ala Asn Pro Leu Ala Ser Ile Asp Ser Ala Leu 
145                 150                 155                 160 


Ser Lys Val Asp Ala Val Arg Ser Ser Leu Gly Ala Ile Gln Asn Arg 
                165                 170                 175     


Phe Asp Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Thr Asn Leu Asn 
            180                 185                 190         


Ser Ala Arg Ser Arg Ile Glu Asp Ala Asp Tyr Ala Thr Glu Val Ser 
        195                 200                 205             


Gln Met Ser Lys Ala Gln Ile Leu Asp Gln Ala Gly Thr Ser Thr Leu 
    210                 215                 220                 


Ala Gln Leu Val Pro Arg Gly Ser His His His His His His Gly 
225                 230                 235                 


