                         SEQUENCE LISTING

<110>  Ohio State Innovation Foundation
 
<120>  STAPLED synthetic constructS

<130>  CYPT-027/01WO 329395-2146

<150>  US 62/894,195
<151>  2019-08-30

<160>  158   

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  1

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Val Ile 
1               5                   10                  15      


Leu 
    


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  2

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Val Ile 
1               5                   10                  15      


Leu 
    


<210>  3
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3

Leu Ser Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Thr Leu 
1               5                   10                  15      


Arg Ile Asp Gln Arg Met Leu Phe 
            20                  


<210>  4
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is any amino acid which can be utilized to form a staple

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is any amino acid which can be utilized to form a staple

<400>  4

Leu Ser Gln Glu Gln Leu Glu His Arg Xaa Arg Ser Leu Xaa Thr Leu 
1               5                   10                  15      


Arg Asp Ile Gln Arg Met Leu Phe 
            20                  


<210>  5
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5

Leu Ser Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Thr Leu 
1               5                   10                  15      


Arg Asp Ile Gln Arg Leu Leu Phe 
            20                  


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid which can be utilized to form a staple

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is any amino acid which can be utilized to form a staple

<400>  6

Arg Arg Trp Pro Arg Xaa Ile Leu Asp Xaa His Val Arg Arg Val Trp 
1               5                   10                  15      


Arg 
    


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<400>  7

Phe Xaa Arg Arg Arg Gln 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<400>  8

Phe Xaa Arg Arg Arg Cys 
1               5       


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  selenocysteine

<400>  9

Phe Xaa Arg Arg Arg Xaa 
1               5       


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  L-napthylalanine

<400>  10

Arg Arg Arg Xaa Phe Gln 
1               5       


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  L-napthylalanine

<400>  11

Arg Arg Arg Arg Xaa Phe 
1               5       


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<400>  12

Phe Xaa Arg Arg Arg Arg 
1               5       


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-glutamine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Phe Xaa Xaa Arg Xaa Arg Xaa 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<400>  14

Phe Xaa Xaa Arg Xaa Arg Gln 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<400>  15

Phe Xaa Arg Arg Arg Arg Gln 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<400>  16

Xaa Xaa Arg Xaa Arg Xaa Gln 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  L-napthylalanine

<400>  17

Arg Arg Phe Arg Xaa Arg Gln 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  L-napthylalanine

<400>  18

Phe Arg Arg Arg Arg Xaa Gln 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  L-napthylalanine

<400>  19

Xaa Arg Phe Arg Xaa Arg Gln 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-napthylalanine

<400>  20

Arg Arg Xaa Phe Arg Arg Gln 
1               5           


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<400>  21

Cys Arg Arg Arg Arg Phe Trp Gln 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-arginine

<400>  22

Phe Xaa Xaa Arg Xaa Arg Xaa Gln 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-napthylalanine

<400>  23

Phe Phe Xaa Arg Arg Arg Arg Gln 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  L-napthylalanine

<400>  24

Arg Phe Arg Phe Arg Xaa Arg Gln 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  selenocysteine

<400>  25

Xaa Arg Arg Arg Arg Phe Trp Gln 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<400>  26

Phe Xaa Arg Arg Arg Arg Gln Lys 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<400>  27

Phe Xaa Arg Arg Arg Arg Gln Cys 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<400>  28

Xaa Xaa Arg Xaa Arg Xaa Arg Gln 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<400>  29

Phe Xaa Arg Arg Arg Arg Arg Gln 
1               5               


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  L-norleucine

<400>  30

Arg Arg Arg Arg Xaa Phe Asp Xaa Cys 
1               5                   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<400>  31

Phe Xaa Arg Arg Arg 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  forms a cyclic peptide

<400>  32

Phe Trp Arg Arg Arg 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  L-napthylalanine

<400>  33

Arg Arg Arg Xaa Phe 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  forms a cyclic peptide

<400>  34

Arg Arg Arg Trp Phe 
1               5   


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<400>  35

Phe Phe Arg Arg Arg Gln 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<400>  36

Phe Phe Xaa Arg Xaa Gln 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<400>  37

Phe Phe Arg Xaa Arg Gln 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<400>  38

Phe Arg Phe Arg Arg Gln 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<400>  39

Phe Arg Arg Phe Arg Gln 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<400>  40

Phe Arg Arg Arg Phe Gln 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-naphthylalanine

<400>  41

Gly Xaa Arg Arg Arg Gln 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<400>  42

Phe Phe Phe Arg Ala Gln 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<400>  43

Phe Phe Phe Arg Arg Gln 
1               5       


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  44

Phe Phe Arg Arg Arg Arg Gln 
1               5           


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  45

Phe Arg Arg Phe Arg Arg Gln 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  46

Phe Arg Arg Arg Phe Arg Gln 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  47

Arg Phe Phe Arg Arg Arg Gln 
1               5           


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  48

Arg Phe Arg Arg Phe Arg Gln 
1               5           


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  49

Phe Arg Phe Arg Arg Arg Gln 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  50

Phe Phe Phe Arg Arg Arg Gln 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  51

Phe Phe Arg Arg Arg Phe Gln 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  52

Phe Arg Phe Phe Arg Arg Gln 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  53

Arg Arg Phe Phe Phe Arg Gln 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  54

Phe Phe Arg Phe Arg Arg Gln 
1               5           


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  55

Phe Phe Arg Arg Phe Arg Gln 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  56

Phe Arg Arg Phe Phe Arg Gln 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  57

Phe Arg Arg Phe Arg Phe Gln 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  58

Phe Arg Phe Arg Phe Arg Gln 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<400>  59

Arg Phe Phe Arg Phe Arg Gln 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-naphthylalanine

<400>  60

Gly Xaa Arg Arg Arg Arg Gln 
1               5           


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<400>  61

Phe Phe Phe Arg Arg Arg Arg Gln 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<400>  62

Arg Phe Phe Arg Arg Arg Arg Gln 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<400>  63

Arg Arg Phe Phe Arg Arg Arg Gln 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<400>  64

Arg Phe Phe Phe Arg Arg Arg Gln 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<400>  65

Arg Arg Phe Phe Phe Arg Arg Gln 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<400>  66

Phe Phe Arg Arg Phe Arg Arg Gln 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<400>  67

Phe Phe Arg Arg Arg Arg Phe Gln 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  forms a cyclic peptide

<400>  68

Phe Arg Arg Phe Phe Arg Arg Gln 
1               5               


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  forms a cyclic peptide

<400>  69

Phe Phe Phe Arg Arg Arg Arg Arg Gln 
1               5                   


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  forms a cyclic peptide

<400>  70

Phe Phe Phe Arg Arg Arg Arg Arg Arg Gln 
1               5                   10  


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<400>  71

Phe Xaa Arg Xaa Arg Xaa Gln 
1               5           


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  72

Xaa Xaa Arg Arg Arg Arg Gln 
1               5           


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<400>  73

Phe Xaa Phe Arg Xaa Arg Gln 
1               5           


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<400>  74

Xaa Phe Xaa Xaa Arg Xaa Gln 
1               5           


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<400>  75

Xaa Phe Xaa Arg Xaa Arg Gln 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<400>  76

Phe Xaa Phe Xaa Arg Xaa Gln 
1               5           


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<400>  77

Xaa Phe Xaa Xaa Arg Xaa Gln 
1               5           


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<400>  78

Xaa Xaa Xaa Xaa Arg Xaa Gln 
1               5           


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<400>  79

Xaa Phe Xaa Xaa Arg Xaa Gln 
1               5           


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<400>  80

Phe Xaa Xaa Arg Xaa Gln 
1               5       


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<400>  81

Xaa Xaa Xaa Arg Xaa Gln 
1               5       


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-arginine

<400>  82

Lys Xaa Phe Arg Xaa Arg Xaa Asp 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-arginine

<400>  83

Xaa Xaa Phe Arg Xaa Arg Xaa Asp 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DISULFID
<222>  (1)..(8)
<223>  Cys residues jopined by disulfide bond

<400>  84

Cys Trp Trp Arg Arg Arg Arg Cys 
1               5               


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DISULFID
<222>  (1)..(9)
<223>  Cys residues jopined by disulfide bond

<400>  85

Cys Trp Trp Val Arg Arg Arg Arg Cys 
1               5                   


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DISULFID
<222>  (1)..(8)
<223>  Cys residues jopined by disulfide bond

<400>  86

Cys Phe Trp Arg Arg Arg Arg Cys 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DISULFID
<222>  (1)..(8)
<223>  Cys residues jopined by disulfide bond

<400>  87

Cys Trp Trp Trp Arg Arg Arg Cys 
1               5               


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-homeoproline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-glutamate

<400>  88

Xaa Xaa Arg Glu Xaa Xaa Xaa 
1               5           


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-homeoproline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-glutamate

<400>  89

Xaa Xaa Arg Arg Xaa Xaa Xaa 
1               5           


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-homeoproline

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa is L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-glutamate

<400>  90

Xaa Xaa Xaa Arg Xaa Xaa Xaa 
1               5           


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-homeoproline

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa is L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is D-arginine

<400>  91

Xaa Xaa Xaa Arg Xaa Xaa Glu 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-homeoproline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-glutamate

<400>  92

Xaa Xaa Phe Arg Xaa Xaa Xaa 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-homeoproline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is D-arginine

<400>  93

Xaa Xaa Phe Arg Xaa Xaa Glu 
1               5           


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-homeoproline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-glutamate

<400>  94

Xaa Xaa Xaa Arg Xaa Xaa Xaa 
1               5           


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-homeoproline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is D-arginine

<400>  95

Xaa Xaa Xaa Arg Xaa Xaa Glu 
1               5           


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-homeoproline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is D-arginine

<400>  96

Xaa Xaa Xaa Arg Xaa Xaa Glu 
1               5           


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-homeoproline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-glutamate

<400>  97

Xaa Xaa Xaa Arg Xaa Xaa Xaa 
1               5           


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Arg is modified with pimelic acid

<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Cyclization between Arg is modified with pimelic acid and Arg is 
       modified with lysine peptoid residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Arg is modified with lysine peptoid residue

<400>  98

Arg Gln Arg Arg Gly Arg Arg Arg 
1               5               


<210>  99
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DISULFID
<222>  (2)..(19)
<223>  Cys residues jopined by disulfide bond

<400>  99

Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg Gly Pro Pro 
1               5                   10                  15      


Val Ser Cys 
            


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  Cyclization between Lys and Glu

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-lysine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-arginine

<400>  100

Lys Xaa Arg Xaa Gly Xaa Lys Xaa Arg Xaa Glu 
1               5                   10      


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Cyclization between Lys and Glu

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is D-arginine

<400>  101

Lys Xaa Arg Xaa Arg Xaa Arg Xaa Arg Xaa Arg Glu 
1               5                   10          


<210>  102
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is D-proline

<400>  102

Arg Val Arg Thr Arg Gly Lys Arg Arg Ile Arg Arg Xaa Pro 
1               5                   10                  


<210>  103
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is D-proline

<400>  103

Arg Thr Arg Thr Arg Gly Lys Arg Arg Ile Arg Val Xaa Pro 
1               5                   10                  


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  104

Trp Arg Trp Arg Trp Arg Trp Arg 
1               5               


<210>  105
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  DISULFID
<222>  (4)..(21)
<223>  Cys residues jopined by disulfide bond

<220>
<221>  DISULFID
<222>  (11)..(23)
<223>  Cys residues jopined by disulfide bond

<220>
<221>  DISULFID
<222>  (17)..(29)
<223>  Cys residues jopined by disulfide bond

<400>  105

Gly Gly Val Cys Pro Lys Ile Leu Lys Lys Cys Arg Arg Asp Ser Asp 
1               5                   10                  15      


Cys Pro Gly Ala Cys Ile Cys Arg Gly Asn Gly Tyr Cys Gly Ser Gly 
            20                  25                  30          


Ser Asp 
        


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Macrocyclization by multicomponent reaction with aziridine 
       aldehyde and isocyanide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-3-cyclohexyl-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is L-cyclohexylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is L-cyclohexylalanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is L-cyclohexylalanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is D-arginine

<400>  106

Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly 
1               5                   10  


<210>  107
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Ser is modified with trimesic acid

<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  N-terminal amine and side chains of two L-2,3-diaminopropionic 
       acid residues bicyclized with trimesic acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is D-valine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is L-4-(phosphonodifluoromethyl)phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is L-2,3-diaminopropionic acid

<400>  107

Ser Xaa Pro Xaa His Xaa Phe Xaa Arg Arg Arg Arg Xaa 
1               5                   10              


<210>  108
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-alanine is modified with trimesic acid

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  N-terminal amine and side chains of two L-2,3-diaminopropionic 
       acid residues bicyclized with trimesic acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is sarcosine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-phosphothreonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is L-homoproline

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is L-naphthylalanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is L-2,3-diaminopropionic acid

<400>  108

Xaa Xaa Asp Xaa Xaa Xaa Arg Ala Xaa Xaa Phe Xaa Arg Arg Arg Arg 
1               5                   10                  15      


Xaa 
    


<210>  109
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  Three Cys side chains bicyclized with tris(bromomethyl)benzene

<400>  109

Cys Arg Arg Ser Arg Arg Gly Cys Gly Arg Arg Ser Arg Arg Cys Gly 
1               5                   10                  15      


<210>  110
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  linked by dodecanoyl moiety

<400>  110

Lys Arg Arg Arg Arg 
1               5   


<210>  111
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  111

Leu Lys Lys Leu Cys Lys Leu Leu Lys Lys Leu Cys Lys Leu Ala Gly 
1               5                   10                  15      


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  Cyclization between Lys and Glu

<400>  112

Arg Arg Arg Arg Lys Arg Arg Arg Glu 
1               5                   


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(9)
<223>  Cyclization between Lys and Glu

<400>  113

Arg Arg Arg Lys Arg Arg Arg Arg Glu 
1               5                   


<210>  114
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(9)
<223>  Cyclization between Lys and Glu

<400>  114

Arg Arg Lys Arg Arg Arg Arg Arg Glu 
1               5                   


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(9)
<223>  Cyclization between Lys and Glu

<400>  115

Arg Lys Arg Arg Arg Arg Arg Arg Glu 
1               5                   


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  116

Cys Arg Cys Arg Cys Arg Cys Arg 
1               5               


<210>  117
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is L-propargylglycine

<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Cyclization by the click reaction between L-propargylglycine and 
       L-6-Azido-2-amino-hexanoic

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is L-6-Azido-2-amino-hexanoic

<400>  117

Xaa Leu Arg Lys Arg Leu Arg Lys Phe Arg Asn Xaa 
1               5                   10          


<210>  118
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaa is L-2,3-diaminopropionic acid

<400>  118

Thr Xaa Xaa Xaa Xaa Leu Xaa Xaa Thr 
1               5                   


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is L-2-amino-3-guanidinylpropionic acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is L-2-amino-3-guanidinylpropionic acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaa is L-2-amino-3-guanidinylpropionic acid

<400>  119

Thr Xaa Xaa Xaa Xaa Leu Xaa Xaa Thr 
1               5                   


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  m-xylene stapled peptidyl inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-Terminal FAM dye

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  120

Gly Gly Tyr Pro Glu Cys Ile Leu Asp Cys His Leu Gln Arg Val Ile 
1               5                   10                  15      


Leu 
    


<210>  121
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(25)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is D-arginine

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  121

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Val Ile 
1               5                   10                  15      


Leu Xaa Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  25  


<210>  122
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(25)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is D-arginine

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  122

Gly Gly Tyr Pro Glu Asp Ile Leu His Lys Asp Leu Gln Arg Val Ala 
1               5                   10                  15      


Leu Xaa Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  25  


<210>  123
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  AMIDATION

<400>  123

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Val Ile 
1               5                   10                  15      


Leu Xaa Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
            20                  25                  30      


<210>  124
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  AMIDATION

<400>  124

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Val Ile 
1               5                   10                  15      


Leu Xaa Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            20                  25          


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  125

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Val Ile 
1               5                   10                  15      


Leu 
    


<210>  126
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is beta-alanine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  AMIDATION

<400>  126

Gly Gly Tyr Pro Glu Cys Ile Leu Asp Cys Lys His Leu Gln Asp Val 
1               5                   10                  15      


Ile Leu Lys Xaa 
            20  


<210>  127
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is beta-alanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  AMIDATION

<400>  127

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Cys Val Ile 
1               5                   10                  15      


Leu Cys Xaa 
            


<210>  128
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is beta-alanine

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  128

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Ile 
1               5                   10                  15      


Leu Xaa 
        


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is tert-leucine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  129

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Trp 
1               5                   10                  15      


Leu 
    


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  130

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa 
1               5                   10                  15      


Leu 
    


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is 1-napthylalanine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  131

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa 
1               5                   10                  15      


Leu 
    


<210>  132
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is 2-napthylalanine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  132

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa 
1               5                   10                  15      


Leu 
    


<210>  133
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  AMIDATION

<400>  133

Xaa Xaa Arg Xaa Arg Xaa Gln Gly Gly Tyr Pro Glu Asp Ile Leu Asp 
1               5                   10                  15      


Lys His Leu Gln Arg Xaa Xaa Leu 
            20                  


<210>  134
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is 2-napthylalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  AMIDATION

<400>  134

Xaa Xaa Arg Xaa Arg Xaa Gln Gly Gly Tyr Pro Glu Asp Ile Leu Asp 
1               5                   10                  15      


Lys His Leu Gln Arg Xaa Xaa Leu 
            20                  


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  AMIDATION

<400>  135

Gly Gly Xaa Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa 
1               5                   10                  15      


Leu 
    


<210>  136
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(25)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is D-arginine

<400>  136

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Ile 
1               5                   10                  15      


Leu Xaa Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  25  


<210>  137
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(25)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is D-arginine

<400>  137

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa 
1               5                   10                  15      


Leu Xaa Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  25  


<210>  138
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  138

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Ser Val Xaa Thr Xaa 
1               5                   10                  15      


<210>  139
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  139

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Glu Val Xaa Thr Xaa 
1               5                   10                  15      


<210>  140
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  140

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Gln Val Xaa Thr Xaa 
1               5                   10                  15      


<210>  141
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is D-glutamate

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  141

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Xaa Val Xaa Thr Xaa 
1               5                   10                  15      


<210>  142
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is D-serine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  142

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Ser Val Xaa Xaa Xaa 
1               5                   10                  15      


<210>  143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  143

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Xaa Val Ile Leu Xaa 
1               5                   10                  15      


<210>  144
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  144

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Ile Leu Xaa 
1               5                   10                  15      


<210>  145
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  145

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa Arg Xaa 
1               5                   10                  15      


<210>  146
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  146

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210>  147
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  147

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Val Xaa Leu Xaa 
1               5                   10                  15      


<210>  148
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  148

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa Arg Cys 
1               5                   10                  15      


<210>  149
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  AMIDATION

<400>  149

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa Xaa Cys 
1               5                   10                  15      


<210>  150
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  DISULFID
<222>  (16)..(17)
<223>  joined by a disulfide bond

<220>
<221>  MISC_FEATURE
<222>  (18)..(25)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is D-arginine

<400>  150

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa Arg Cys 
1               5                   10                  15      


Cys Phe Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  25  


<210>  151
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  DISULFID
<222>  (16)..(17)
<223>  joined by a disulfide bond

<220>
<221>  MISC_FEATURE
<222>  (18)..(25)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is D-arginine

<400>  151

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa Xaa Cys 
1               5                   10                  15      


Cys Phe Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  25  


<210>  152
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  DISULFID
<222>  (16)..(17)
<223>  joined by a disulfide bond

<220>
<221>  MISC_FEATURE
<222>  (18)..(24)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is D-arginine

<400>  152

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa Arg Cys 
1               5                   10                  15      


Cys Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  


<210>  153
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  DISULFID
<222>  (16)..(17)
<223>  joined by a disulfide bond

<220>
<221>  MISC_FEATURE
<222>  (18)..(24)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is D-arginine

<400>  153

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa Xaa Cys 
1               5                   10                  15      


Cys Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  


<210>  154
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  DISULFID
<222>  (16)..(17)
<223>  joined by a disulfide bond

<220>
<221>  MISC_FEATURE
<222>  (18)..(25)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is D-arginine

<400>  154

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa Arg Cys 
1               5                   10                  15      


Cys Phe Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  25  


<210>  155
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is tert-leucine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is 3-benzothienyl-l-alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  DISULFID
<222>  (16)..(17)
<223>  joined by a disulfide bond

<220>
<221>  MISC_FEATURE
<222>  (18)..(25)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is D-arginine

<400>  155

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Xaa Xaa Cys 
1               5                   10                  15      


Cys Phe Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  25  


<210>  156
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is beta-hydroxyvaline

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  156

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Ile Leu 
1               5                   10                  15  


<210>  157
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is beta-hydroxyvaline

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is D-argininine

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  157

Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Ile Xaa 
1               5                   10                  15  


<210>  158
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is beta-hydroxyvaline

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  linked by a polyethylene glycol moiety (miniPEG)2

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is L-2,3-diaminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(25)
<223>  forms a cyclic peptide

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  L-napthylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is D-arginine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is D-arginine

<400>  158

Gly Gly Tyr Pro Glu Asp Ile Leu Asp Lys His Leu Gln Arg Xaa Ile 
1               5                   10                  15      


Leu Xaa Xaa Xaa Arg Xaa Arg Xaa Gln 
            20                  25  


