                               SEQUENCE LISTING

<110> LYGOS, INC.
 
<120> RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE

<130> LYGOS-0030-01-WO

<140> PCT/US2020/048820
<141> 2020-08-31

<150> 62/894,548
<151> 2019-08-30

<160> 66    

<170> PatentIn version 3.5

<210> 1
<211> 500
<212> PRT
<213> Saccharomyces cerevisiae

<400> 1
Met Leu Arg Asn Thr Leu Lys Cys Ala Gln Leu Ser Ser Lys Tyr Gly 
1               5                   10                  15      


Phe Lys Thr Thr Thr Arg Thr Phe Met Thr Thr Gln Pro Gln Leu Asn 
            20                  25                  30          


Val Thr Asp Ala Pro Pro Val Leu Phe Thr Val Gln Asp Thr Ala Arg 
        35                  40                  45              


Val Ile Thr Leu Asn Arg Pro Lys Lys Leu Asn Ala Leu Asn Ala Glu 
    50                  55                  60                  


Met Ser Glu Ser Met Phe Lys Thr Leu Asn Glu Tyr Ala Lys Ser Asp 
65                  70                  75                  80  


Thr Thr Asn Leu Val Ile Leu Lys Ser Ser Asn Arg Pro Arg Ser Phe 
                85                  90                  95      


Cys Ala Gly Gly Asp Val Ala Thr Val Ala Ile Phe Asn Phe Asn Lys 
            100                 105                 110         


Glu Phe Ala Lys Ser Ile Lys Phe Phe Thr Asp Glu Tyr Ser Leu Asn 
        115                 120                 125             


Phe Gln Ile Ala Thr Tyr Leu Lys Pro Ile Val Thr Phe Met Asp Gly 
    130                 135                 140                 


Ile Thr Met Gly Gly Gly Val Gly Leu Ser Ile His Thr Pro Phe Arg 
145                 150                 155                 160 


Ile Ala Thr Glu Asn Thr Lys Trp Ala Met Pro Glu Met Asp Ile Gly 
                165                 170                 175     


Phe Phe Pro Asp Val Gly Ser Thr Phe Ala Leu Pro Arg Ile Val Thr 
            180                 185                 190         


Leu Ala Asn Ser Asn Ser Gln Met Ala Leu Tyr Leu Cys Leu Thr Gly 
        195                 200                 205             


Glu Val Val Thr Gly Ala Asp Ala Tyr Met Leu Gly Leu Ala Ser His 
    210                 215                 220                 


Tyr Val Ser Ser Glu Asn Leu Asp Ala Leu Gln Lys Arg Leu Gly Glu 
225                 230                 235                 240 


Ile Ser Pro Pro Phe Asn Asn Asp Pro Gln Ser Ala Tyr Phe Phe Gly 
                245                 250                 255     


Met Val Asn Glu Ser Ile Asp Glu Phe Val Ser Pro Leu Pro Lys Asp 
            260                 265                 270         


Tyr Val Phe Lys Tyr Ser Asn Glu Lys Leu Asn Val Ile Glu Ala Cys 
        275                 280                 285             


Phe Asn Leu Ser Lys Asn Gly Thr Ile Glu Asp Ile Met Asn Asn Leu 
    290                 295                 300                 


Arg Gln Tyr Glu Gly Ser Ala Glu Gly Lys Ala Phe Ala Gln Glu Ile 
305                 310                 315                 320 


Lys Thr Lys Leu Leu Thr Lys Ser Pro Ser Ser Leu Gln Ile Ala Leu 
                325                 330                 335     


Arg Leu Val Gln Glu Asn Ser Arg Asp His Ile Glu Ser Ala Ile Lys 
            340                 345                 350         


Arg Asp Leu Tyr Thr Ala Ala Asn Met Cys Met Asn Gln Asp Ser Leu 
        355                 360                 365             


Val Glu Phe Ser Glu Ala Thr Lys His Lys Leu Ile Asp Lys Gln Arg 
    370                 375                 380                 


Val Pro Tyr Pro Trp Thr Lys Lys Glu Gln Leu Phe Val Ser Gln Leu 
385                 390                 395                 400 


Thr Ser Ile Thr Ser Pro Lys Pro Ser Leu Pro Met Ser Leu Leu Arg 
                405                 410                 415     


Asn Thr Ser Asn Val Thr Trp Thr Gln Tyr Pro Tyr His Ser Lys Tyr 
            420                 425                 430         


Gln Leu Pro Thr Glu Gln Glu Ile Ala Ala Tyr Ile Glu Lys Arg Thr 
        435                 440                 445             


Asn Asp Asp Thr Gly Ala Lys Val Thr Glu Arg Glu Val Leu Asn His 
    450                 455                 460                 


Phe Ala Asn Val Ile Pro Ser Arg Arg Gly Lys Leu Gly Ile Gln Ser 
465                 470                 475                 480 


Leu Cys Lys Ile Val Cys Glu Arg Lys Cys Glu Glu Val Asn Asp Gly 
                485                 490                 495     


Leu Arg Trp Lys 
            500 


<210> 2
<211> 1000
<212> DNA
<213> Haemophilus influenzae

<400> 2
atgttttaca ctgaaactta tgatgtgatt gtgatcggtg gtggtcatgc gggtacagaa       60

gccgcacttg caccagctcg tatgggattt aaaacccttt tattaacaca taatgtagat      120

actttagggc aaatgtcttg taaccctgca attggtggga tcggtaaagg tcatttagta      180

aaagaagtag atgcaatggg cggtttaatg gcgcatgctg cagataaagc agggatccaa      240

tttcgtactt taaatagcag taaaggccca gcagtgcgtg ctactcgagc tcaagctgac      300

agagttctat atcgtcaagc tgttcgtact gcattagaaa atcaacctaa tttagatatt      360

ttccaacaag aagcgaccga tattctgatt aagcaagatc gagttacagg cgttagcaca      420

aaaatgggat taacttttcg tgctaaatca gtggtattaa ctgcgggtac tttcttagct      480

ggtaaaattc atattggttt ggaaaattat gaaggtggcc gtgcagggga tcctgcttct      540

gtaaatcttt cacatcgatt aagagatctc ggattacgtg tagatcgcct taaaacaggt      600

acaccgccgc gtattgatgc acgtacgatc aattttgata ttttagctaa acaacacggt      660

gatgctgttt tacctgtgtt ttcttttatg ggatcagttg atgatcaccc tcaacaaatt      720

ccttgttata taactcatac caatgaacaa acccatgaag tgatccgtaa taacttggat      780

cgcagtccaa tgtatactgg tgtgattgaa gggatcggtc cacgttattg cccatccatt      840

gaagataaag tgatgcgttt ctcggatcgt aattcacatc aaatttattt agaaccagaa      900

ggcttaacca gtaatgaagt gtatccaaac gggatctcta ccagtttacc gtttgacgtg      960

caaatgggca ttgtgaattc tatgaaaggt ttagaaaacg                           1000


<210> 3
<211> 224
<212> PRT
<213> Acinetobacter calcoaceticus

<400> 3
Met Asn Ser Ile Ala Glu Leu Pro Leu Ser Ile Gln Ile Ser Lys Lys 
1               5                   10                  15      


Leu Glu Asp Asp Ile Ile Tyr Gly Phe Tyr Leu Pro Gly Thr Lys Leu 
            20                  25                  30          


Asp Glu Gln Glu Leu Cys Glu Arg Tyr Gly Ala Ser Arg Thr Pro Ile 
        35                  40                  45              


Arg Glu Ala Leu Lys Leu Leu Ala Ala Glu Gly Leu Val Glu Ile Arg 
    50                  55                  60                  


Pro Arg Arg Gly Ala Ile Ile Pro Thr Ile Asn Pro Leu Thr Leu Cys 
65                  70                  75                  80  


Glu Met Phe Glu Val Met Ala Glu Leu Glu Ala Met Cys Gly Arg Leu 
                85                  90                  95      


Ala Ala Arg Arg Ile Gln Pro Glu Glu Lys Leu Glu Leu Gln Arg Leu 
            100                 105                 110         


His Gln Leu Cys Gln Asp Tyr Leu Asn Gln Asn Asp Ser Glu Asn Tyr 
        115                 120                 125             


Tyr Glu Ala Asn Arg Leu Phe His Phe Ala Ile Tyr Gln Ala Ser His 
    130                 135                 140                 


Asn Ala Phe Leu Ile Glu Gln Ala Cys Thr Leu His Lys Arg Leu His 
145                 150                 155                 160 


Pro Tyr Arg Arg Leu Gln Leu Arg Val Asn Asn Arg Met Asn Asn Ser 
                165                 170                 175     


Phe Thr Glu His Asn Glu Ile Leu Glu Ala Ile Phe Ala Gly Asn Glu 
            180                 185                 190         


Gln Gln Ala Glu Ala Leu Leu Lys Ala His Val Val Ile Gln Gly Gln 
        195                 200                 205             


Lys Phe Thr Asp Phe Ile Ser Thr Ile Glu Ser Leu Gln Pro Lys Ser 
    210                 215                 220                 


<210> 4
<211> 222
<212> PRT
<213> Rhizobium leguminosarum

<400> 4
Met Arg Lys Val Lys Arg Met Ser Glu Asn Val Gly Arg Trp Leu Arg 
1               5                   10                  15      


Asp Glu Ile Glu Asn Ser Ile Leu Ser Asn Glu Phe Ser Pro Gly Glu 
            20                  25                  30          


Arg Leu Asp Glu Thr Val Leu Ala Thr Arg Phe Gly Val Ser Arg Thr 
        35                  40                  45              


Pro Val Arg Glu Ala Leu Met Gln Leu Asp Ala Ile Gly Leu Ile Glu 
    50                  55                  60                  


Ile Arg Pro Arg Arg Gly Ala Ile Val Ile Asp Pro Gly Pro His Arg 
65                  70                  75                  80  


Val Tyr Glu Met Phe Glu Val Met Ala Glu Leu Glu Gly Leu Ala Gly 
                85                  90                  95      


Ser Leu Ala Ala Arg Arg Leu Asp Lys Thr Ser Arg Glu Ala Ile Thr 
            100                 105                 110         


Ala Thr His Gly Arg Cys Glu Lys Ser Ala Ala Ala Gly Asp Ser Asp 
        115                 120                 125             


Ala Tyr Tyr Tyr Asp Asn Glu Glu Phe His Lys Ala Ile Tyr Ala Ala 
    130                 135                 140                 


Gly Arg Ser Asp Phe Leu Glu Glu Gln Cys Leu Gln Leu His Arg Arg 
145                 150                 155                 160 


Leu Arg Pro Asp Arg Arg Leu Gln Leu Arg Val Arg Asn Arg Leu Ser 
                165                 170                 175     


Thr Ser Phe Leu Glu His Cys Ala Ile Val Asp Ala Ile Phe Ala Gly 
            180                 185                 190         


Asp Gly Asp Glu Ala Arg Arg Leu Leu Arg Gly His Val Gly Ile Gln 
        195                 200                 205             


Gly Glu Arg Phe Ser Asp Leu Val Ala Ser Met Ala Ala Arg 
    210                 215                 220         


<210> 5
<211> 308
<212> PRT
<213> Klebsiella pneumoniae

<400> 5
Met Lys Asp Asp Ile Asn Gln Glu Ile Thr Phe Arg Lys Leu Ser Val 
1               5                   10                  15      


Phe Met Met Phe Met Ala Lys Gly Asn Ile Ala Arg Thr Ala Glu Ala 
            20                  25                  30          


Met Lys Leu Ser Ser Val Ser Val His Arg Ala Leu His Thr Leu Glu 
        35                  40                  45              


Glu Gly Val Gly Cys Pro Leu Phe Val His Lys Gly Arg Asn Leu Leu 
    50                  55                  60                  


Pro Leu Gln Ala Ala Trp Thr Leu Leu Glu Tyr Cys Gln Asp Val Ile 
65                  70                  75                  80  


Ser Leu Met Asn Arg Gly Leu Glu Ala Thr Arg Lys Val Ala Gly Val 
                85                  90                  95      


Gly Gln Gly Arg Leu Arg Ile Gly Thr Leu Tyr Ser Leu Thr Leu Glu 
            100                 105                 110         


Thr Val Pro Arg Ile Ile Met Gly Met Lys Leu Arg Arg Pro Glu Leu 
        115                 120                 125             


Glu Leu Asp Leu Thr Met Gly Ser Asn Gln Met Leu Leu Asp Met Leu 
    130                 135                 140                 


Glu Asp Asp Ala Leu Asp Ala Ile Leu Ile Ala Thr Asn Glu Gly Glu 
145                 150                 155                 160 


Phe Asn Asn Thr Ala Phe Asp Val Val Pro Leu Phe Glu Asp Asp Ile 
                165                 170                 175     


Phe Leu Ala Ala Pro Ala Thr Glu Arg Leu Asp Ala Ser Arg Leu Ala 
            180                 185                 190         


Asp Leu Arg Asp Tyr Ala Asp Arg Lys Phe Val Ser Leu Ala Glu Gly 
        195                 200                 205             


Phe Ala Thr Tyr Ala Gly Phe Arg Glu Ala Phe His Ile Ala Gly Phe 
    210                 215                 220                 


Glu Pro Glu Ile Val Thr Arg Val Asn Asp Ile Phe Ser Met Ile Ser 
225                 230                 235                 240 


Leu Val Gln Ala Gly Val Gly Phe Ala Leu Leu Pro Gly Arg Met Lys 
                245                 250                 255     


Lys Val Tyr Glu Lys Asp Val Gln Leu Leu Lys Leu Ala Glu Pro Tyr 
            260                 265                 270         


Gln Met Arg Gln Leu Ile Ser Ile Val Tyr Ser His His Arg Glu Arg 
        275                 280                 285             


Asp Ala Asp Leu Leu Ala Leu Ala Ala Glu Gly Arg Met Tyr Ala Arg 
    290                 295                 300                 


Ser Ile Asn Arg 
305             


<210> 6
<211> 77
<212> DNA
<213> Acinetobacter calcoaceticus

<400> 6
aaaaaaattg tatacaattt atgtttattt gagtacaaag cattgtacac tgaatacaga       60

taggctataa ctatacc                                                      77


<210> 7
<211> 522
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (3)..(3)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (4)..(4)
<223> S or T

<220>
<221> MOD_RES
<222> (5)..(5)
<223> S or T

<220>
<221> MOD_RES
<222> (6)..(6)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (7)..(7)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (12)..(12)
<223> S or T

<220>
<221> MOD_RES
<222> (13)..(13)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (14)..(14)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (20)..(20)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (21)..(21)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (22)..(22)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (23)..(23)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (24)..(24)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (27)..(27)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (28)..(28)
<223> S or T

<220>
<221> MOD_RES
<222> (29)..(29)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (30)..(30)
<223> S or T

<220>
<221> MOD_RES
<222> (31)..(31)
<223> S or T

<220>
<221> MOD_RES
<222> (32)..(32)
<223> S or T

<220>
<221> MOD_RES
<222> (35)..(35)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (40)..(40)
<223> S or T

<220>
<221> MOD_RES
<222> (41)..(41)
<223> S or T

<220>
<221> MOD_RES
<222> (42)..(42)
<223> S or T

<220>
<221> MOD_RES
<222> (44)..(44)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (46)..(46)
<223> S or T

<220>
<221> MOD_RES
<222> (47)..(47)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (49)..(49)
<223> D or E

<220>
<221> MOD_RES
<222> (50)..(50)
<223> S or T

<220>
<221> MOD_RES
<222> (53)..(53)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (54)..(54)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (55)..(55)
<223> S or T

<220>
<221> MOD_RES
<222> (60)..(60)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (67)..(67)
<223> S or T

<220>
<221> MOD_RES
<222> (68)..(68)
<223> D or E

<220>
<221> MOD_RES
<222> (70)..(70)
<223> S or T

<220>
<221> MOD_RES
<222> (71)..(71)
<223> D or E

<220>
<221> MOD_RES
<222> (72)..(72)
<223> S or T

<220>
<221> MOD_RES
<222> (73)..(73)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (75)..(75)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (76)..(76)
<223> S or T

<220>
<221> MOD_RES
<222> (81)..(81)
<223> S or T

<220>
<221> MOD_RES
<222> (84)..(84)
<223> D or E

<220>
<221> MOD_RES
<222> (85)..(85)
<223> S or T

<220>
<221> MOD_RES
<222> (86)..(86)
<223> S or T

<220>
<221> MOD_RES
<222> (88)..(88)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (89)..(89)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (90)..(90)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (91)..(91)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (92)..(92)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (94)..(94)
<223> S or T

<220>
<221> MOD_RES
<222> (99)..(99)
<223> S or T

<220>
<221> MOD_RES
<222> (100)..(100)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (108)..(108)
<223> S or T

<220>
<221> MOD_RES
<222> (109)..(109)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (111)..(111)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (112)..(112)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (114)..(114)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (115)..(115)
<223> D or E

<220>
<221> MOD_RES
<222> (116)..(116)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (117)..(117)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (119)..(119)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (120)..(120)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (121)..(121)
<223> S or T

<220>
<221> MOD_RES
<222> (122)..(122)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (123)..(123)
<223> D or E

<220>
<221> MOD_RES
<222> (126)..(126)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (127)..(127)
<223> S or T

<220>
<221> MOD_RES
<222> (128)..(128)
<223> A, D, R, H, K, S, T, N, Q, or Y

<220>
<221> MOD_RES
<222> (131)..(131)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (135)..(135)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (139)..(139)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (142)..(142)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (143)..(143)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (144)..(144)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (145)..(145)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (147)..(147)
<223> D or E

<220>
<221> MOD_RES
<222> (157)..(157)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (158)..(158)
<223> S or T

<220>
<221> MOD_RES
<222> (159)..(159)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (161)..(161)
<223> S or T

<220>
<221> MOD_RES
<222> (165)..(165)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (171)..(171)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (187)..(187)
<223> S or T

<220>
<221> MOD_RES
<222> (188)..(188)
<223> S or T

<220>
<221> MOD_RES
<222> (191)..(191)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (193)..(193)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (194)..(194)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (195)..(195)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (196)..(196)
<223> S or T

<220>
<221> MOD_RES
<222> (197)..(197)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (200)..(200)
<223> S or T

<220>
<221> MOD_RES
<222> (201)..(201)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (202)..(202)
<223> S or T

<220>
<221> MOD_RES
<222> (204)..(204)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (206)..(206)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (210)..(210)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (213)..(213)
<223> D or E

<220>
<221> MOD_RES
<222> (214)..(214)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (215)..(215)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (216)..(216)
<223> S or T

<220>
<221> MOD_RES
<222> (218)..(218)
<223> D or E

<220>
<221> MOD_RES
<222> (219)..(219)
<223> D or E

<220>
<221> MOD_RES
<222> (222)..(222)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (223)..(223)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (225)..(225)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (230)..(230)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (231)..(231)
<223> S or T

<220>
<221> MOD_RES
<222> (232)..(232)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (233)..(233)
<223> D or E

<220>
<221> MOD_RES
<222> (235)..(235)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (236)..(236)
<223> D or E

<220>
<221> MOD_RES
<222> (237)..(237)
<223> D or E

<220>
<221> MOD_RES
<222> (239)..(239)
<223> D or E

<220>
<221> MOD_RES
<222> (240)..(240)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (245)..(245)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (246)..(246)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (248)..(248)
<223> S or T

<220>
<221> MOD_RES
<222> (249)..(249)
<223> D or E

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (251)..(251)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (252)..(252)
<223> D or E

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (255)..(255)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (256)..(256)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (257)..(257)
<223> S or T

<220>
<221> MOD_RES
<222> (259)..(259)
<223> S or T

<220>
<221> MOD_RES
<222> (260)..(260)
<223> D or E

<220>
<221> MOD_RES
<222> (261)..(261)
<223> D or E

<220>
<221> MOD_RES
<222> (264)..(264)
<223> D or E

<220>
<221> MOD_RES
<222> (265)..(265)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (266)..(266)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (268)..(268)
<223> D or E

<220>
<221> MOD_RES
<222> (269)..(269)
<223> S or T

<220>
<221> MOD_RES
<222> (270)..(270)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (271)..(271)
<223> D or E

<220>
<221> MOD_RES
<222> (274)..(274)
<223> S or T

<220>
<221> MOD_RES
<222> (275)..(275)
<223> S or T

<220>
<221> MOD_RES
<222> (277)..(277)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (279)..(279)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (280)..(280)
<223> D or E

<220>
<221> MOD_RES
<222> (282)..(282)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (284)..(284)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (286)..(286)
<223> S or T

<220>
<221> MOD_RES
<222> (288)..(288)
<223> D or E

<220>
<221> MOD_RES
<222> (289)..(289)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (291)..(291)
<223> D or E

<220>
<221> MOD_RES
<222> (294)..(294)
<223> D or E

<220>
<221> MOD_RES
<222> (295)..(295)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (298)..(298)
<223> D or E

<220>
<221> MOD_RES
<222> (299)..(299)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (300)..(300)
<223> S or T

<220>
<221> MOD_RES
<222> (301)..(301)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (302)..(302)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (303)..(303)
<223> S or T

<220>
<221> MOD_RES
<222> (304)..(304)
<223> S or T

<220>
<221> MOD_RES
<222> (305)..(305)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (306)..(306)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (307)..(307)
<223> D or E

<220>
<221> MOD_RES
<222> (308)..(308)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (309)..(309)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (310)..(310)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (311)..(311)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (313)..(313)
<223> D or E

<220>
<221> MOD_RES
<222> (314)..(314)
<223> D or E

<220>
<221> MOD_RES
<222> (315)..(315)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (316)..(316)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (317)..(317)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (319)..(319)
<223> D or E

<220>
<221> MOD_RES
<222> (321)..(321)
<223> S or T

<220>
<221> MOD_RES
<222> (322)..(322)
<223> D or E

<220>
<221> MOD_RES
<222> (323)..(323)
<223> D or E

<220>
<221> MOD_RES
<222> (325)..(325)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (326)..(326)
<223> D or E

<220>
<221> MOD_RES
<222> (329)..(329)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (330)..(330)
<223> D or E

<220>
<221> MOD_RES
<222> (331)..(331)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (332)..(332)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (333)..(333)
<223> D or E

<220>
<221> MOD_RES
<222> (334)..(334)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (336)..(336)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (337)..(337)
<223> S or T

<220>
<221> MOD_RES
<222> (341)..(341)
<223> S or T

<220>
<221> MOD_RES
<222> (343)..(343)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (345)..(345)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (347)..(347)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (348)..(348)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (349)..(349)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (350)..(350)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (351)..(351)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (352)..(352)
<223> D or E

<220>
<221> MOD_RES
<222> (354)..(354)
<223> S or T

<220>
<221> MOD_RES
<222> (355)..(355)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (356)..(356)
<223> D or E

<220>
<221> MOD_RES
<222> (357)..(357)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (358)..(358)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (359)..(359)
<223> D or E

<220>
<221> MOD_RES
<222> (360)..(360)
<223> S or T

<220>
<221> MOD_RES
<222> (362)..(362)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (363)..(363)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (364)..(364)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (367)..(367)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (370)..(370)
<223> S or T

<220>
<221> MOD_RES
<222> (374)..(374)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (376)..(376)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (377)..(377)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (378)..(378)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (380)..(380)
<223> D or E

<220>
<221> MOD_RES
<222> (381)..(381)
<223> S or T

<220>
<221> MOD_RES
<222> (382)..(382)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (383)..(383)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (386)..(386)
<223> S or T

<220>
<221> MOD_RES
<222> (387)..(387)
<223> D or E

<220>
<221> MOD_RES
<222> (389)..(389)
<223> S or T

<220>
<221> MOD_RES
<222> (390)..(390)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (391)..(391)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (394)..(394)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (395)..(395)
<223> D or E

<220>
<221> MOD_RES
<222> (398)..(398)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (399)..(399)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (404)..(404)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (405)..(405)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (406)..(406)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (407)..(407)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (408)..(408)
<223> D or E

<220>
<221> MOD_RES
<222> (409)..(409)
<223> D or E

<220>
<221> MOD_RES
<222> (410)..(410)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (411)..(411)
<223> S or T

<220>
<221> MOD_RES
<222> (412)..(412)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (413)..(413)
<223> S or T

<220>
<221> MOD_RES
<222> (415)..(415)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (416)..(416)
<223> S or T

<220>
<221> MOD_RES
<222> (417)..(417)
<223> S or T

<220>
<221> MOD_RES
<222> (418)..(418)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (419)..(419)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (420)..(420)
<223> S or T

<220>
<221> MOD_RES
<222> (422)..(422)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (424)..(424)
<223> S or T

<220>
<221> MOD_RES
<222> (425)..(425)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (427)..(427)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (428)..(428)
<223> S or T

<220>
<221> MOD_RES
<222> (430)..(430)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (431)..(431)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (433)..(433)
<223> S or T

<220>
<221> MOD_RES
<222> (434)..(434)
<223> S or T

<220>
<221> MOD_RES
<222> (436)..(436)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (439)..(439)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (440)..(440)
<223> D or E

<220>
<221> MOD_RES
<222> (443)..(443)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (444)..(444)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (445)..(445)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (446)..(446)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (451)..(451)
<223> S or T

<220>
<221> MOD_RES
<222> (452)..(452)
<223> D or E

<220>
<221> MOD_RES
<222> (453)..(453)
<223> S or T

<220>
<221> MOD_RES
<222> (454)..(454)
<223> D or E

<220>
<221> MOD_RES
<222> (455)..(455)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (456)..(456)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (459)..(459)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (460)..(460)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (461)..(461)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (462)..(462)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (463)..(463)
<223> D or E

<220>
<221> MOD_RES
<222> (465)..(465)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (467)..(467)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (469)..(469)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (470)..(470)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (471)..(471)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (472)..(472)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (473)..(473)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (474)..(474)
<223> S or T

<220>
<221> MOD_RES
<222> (475)..(475)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (476)..(476)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (477)..(477)
<223> D or E

<220>
<221> MOD_RES
<222> (478)..(478)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (479)..(479)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (480)..(480)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (481)..(481)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (483)..(483)
<223> S or T

<220>
<221> MOD_RES
<222> (485)..(485)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (487)..(487)
<223> D or E

<220>
<221> MOD_RES
<222> (488)..(488)
<223> S or T

<220>
<221> MOD_RES
<222> (489)..(489)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (490)..(490)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (491)..(491)
<223> D or E

<220>
<221> MOD_RES
<222> (493)..(493)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (495)..(495)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (496)..(496)
<223> D or E

<220>
<221> MOD_RES
<222> (497)..(497)
<223> S or T

<220>
<221> MOD_RES
<222> (498)..(498)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (499)..(499)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (500)..(500)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (501)..(501)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (502)..(502)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (503)..(503)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (504)..(504)
<223> D or E

<220>
<221> MOD_RES
<222> (505)..(505)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (506)..(506)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (508)..(508)
<223> S or T

<220>
<221> MOD_RES
<222> (509)..(509)
<223> D or E

<220>
<221> MOD_RES
<222> (510)..(510)
<223> D or E

<220>
<221> MOD_RES
<222> (511)..(511)
<223> D or E

<220>
<221> MOD_RES
<222> (513)..(513)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (516)..(516)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (517)..(517)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (519)..(519)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (520)..(520)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (521)..(521)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (522)..(522)
<223> Any amino acid 

<400> 7
Met Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Gln Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Ala Gln Xaa Asn Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Phe Xaa Xaa Gln 
        35                  40                  45              


Xaa Xaa Ala Arg Xaa Xaa Xaa Leu Asn Arg Pro Xaa Lys Leu Asn Ala 
    50                  55                  60                  


Leu Asn Xaa Xaa Met Xaa Xaa Xaa Xaa Phe Xaa Xaa Leu Asn Glu Tyr 
65                  70                  75                  80  


Xaa Lys Ser Xaa Xaa Xaa Asn Xaa Xaa Xaa Xaa Xaa Ser Xaa Asn Gln 
                85                  90                  95      


Pro Arg Xaa Xaa Cys Ala Gly Gly Asp Val Ala Xaa Xaa Ala Xaa Xaa 
            100                 105                 110         


Asn Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Phe Phe Xaa Xaa Xaa 
        115                 120                 125             


Tyr Ser Xaa Asn Phe Gln Xaa Ala Thr Tyr Xaa Lys Pro Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Met Xaa Gly Ile Thr Met Gly Gly Gly Val Gly Xaa Xaa Xaa His 
145                 150                 155                 160 


Xaa Pro Phe Arg Xaa Ala Thr Glu Asn Thr Xaa Trp Ala Met Pro Glu 
                165                 170                 175     


Met Asp Ile Gly Phe Phe Pro Asp Val Gly Xaa Xaa Phe Ala Xaa Pro 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Ala Asn Xaa Xaa Xaa Gln Xaa Ala Xaa Tyr Leu 
        195                 200                 205             


Cys Xaa Thr Gly Xaa Xaa Xaa Xaa Gly Xaa Xaa Ala Tyr Xaa Xaa Gly 
    210                 215                 220                 


Xaa Ala Ser His Tyr Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Leu Xaa Xaa 
225                 230                 235                 240 


Arg Leu Gly Glu Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Gln Xaa Xaa Xaa Phe Phe Xaa Xaa Xaa Asn Xaa Xaa Xaa Xaa Glu 
            260                 265                 270         


Phe Xaa Xaa Pro Xaa Pro Xaa Xaa Tyr Xaa Phe Xaa Tyr Xaa Asn Xaa 
        275                 280                 285             


Xaa Leu Xaa Val Ile Xaa Xaa Cys Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Tyr Xaa Gly 
305                 310                 315                 320 


Xaa Xaa Xaa Ala Xaa Xaa Phe Ala Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa 
                325                 330                 335     


Xaa Lys Ser Pro Xaa Ser Xaa Gln Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Asp Leu Xaa Thr 
        355                 360                 365             


Ala Xaa Asn Met Cys Xaa Asn Xaa Xaa Xaa Gln Xaa Xaa Xaa Xaa Glu 
    370                 375                 380                 


Phe Xaa Xaa Ala Xaa Xaa Xaa Lys Leu Xaa Xaa Lys Gln Xaa Xaa Pro 
385                 390                 395                 400 


Tyr Pro Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Pro Xaa Pro Xaa Xaa Pro Xaa Xaa Leu Xaa Xaa Asn 
            420                 425                 430         


Xaa Xaa Asn Xaa Thr Trp Xaa Xaa Tyr Pro Xaa Xaa Xaa Xaa Tyr Gln 
        435                 440                 445             


Leu Pro Xaa Xaa Xaa Xaa Xaa Xaa Gln Tyr Xaa Xaa Xaa Xaa Xaa Asn 
    450                 455                 460                 


Xaa Asn Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Phe Xaa Asn Xaa Asn Xaa Xaa Xaa Xaa Xaa Lys Xaa Gly Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Ala 
            500                 505                 510         


Xaa Gly Gly Xaa Xaa Trp Xaa Xaa Xaa Xaa 
        515                 520         


<210> 8
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (9)..(9)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (10)..(10)
<223> S or T

<220>
<221> MOD_RES
<222> (11)..(11)
<223> D or E

<220>
<221> MOD_RES
<222> (16)..(16)
<223> S or T

<220>
<221> MOD_RES
<222> (31)..(31)
<223> D or E

<220>
<221> MOD_RES
<222> (45)..(45)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (46)..(46)
<223> D or E

<220>
<221> MOD_RES
<222> (47)..(47)
<223> D or E

<220>
<221> MOD_RES
<222> (48)..(48)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (51)..(51)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (59)..(59)
<223> S or T

<220>
<221> MOD_RES
<222> (79)..(79)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (83)..(83)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (86)..(86)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (89)..(89)
<223> D or E

<220>
<221> MOD_RES
<222> (91)..(91)
<223> A, D, R, H, K, S, T, N, Q, or Y

<220>
<221> MOD_RES
<222> (93)..(93)
<223> D or E

<220>
<221> MOD_RES
<222> (98)..(98)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (102)..(102)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (125)..(125)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (131)..(131)
<223> D or E

<220>
<221> MOD_RES
<222> (132)..(132)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (156)..(156)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (161)..(161)
<223> S or T

<220>
<221> MOD_RES
<222> (163)..(163)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (168)..(168)
<223> S or T

<220>
<221> MOD_RES
<222> (170)..(170)
<223> S or T

<220>
<221> MOD_RES
<222> (171)..(171)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (175)..(175)
<223> S or T

<220>
<221> MOD_RES
<222> (188)..(188)
<223> S or T

<220>
<221> MOD_RES
<222> (189)..(189)
<223> S or T

<220>
<221> MOD_RES
<222> (190)..(190)
<223> D or E

<220>
<221> MOD_RES
<222> (191)..(191)
<223> S or T

<220>
<221> MOD_RES
<222> (194)..(194)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (197)..(197)
<223> S or T

<220>
<221> MOD_RES
<222> (198)..(198)
<223> D or E

<220>
<221> MOD_RES
<222> (199)..(199)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (200)..(200)
<223> D or E

<220>
<221> MOD_RES
<222> (201)..(201)
<223> S or T

<220>
<221> MOD_RES
<222> (202)..(202)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (205)..(205)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (206)..(206)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (207)..(207)
<223> D or E

<220>
<221> MOD_RES
<222> (208)..(208)
<223> D or E

<220>
<221> MOD_RES
<222> (209)..(209)
<223> D or E

<220>
<221> MOD_RES
<222> (211)..(211)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (212)..(212)
<223> S or T

<220>
<221> MOD_RES
<222> (213)..(213)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (216)..(216)
<223> D or E

<220>
<221> MOD_RES
<222> (217)..(217)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (218)..(218)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (219)..(219)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (220)..(220)
<223> S or T

<220>
<221> MOD_RES
<222> (223)..(223)
<223> S or T

<220>
<221> MOD_RES
<222> (224)..(224)
<223> S or T

<220>
<221> MOD_RES
<222> (225)..(225)
<223> S or T

<220>
<221> MOD_RES
<222> (226)..(226)
<223> S or T

<220>
<221> MOD_RES
<222> (227)..(227)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (228)..(228)
<223> D or E

<220>
<221> MOD_RES
<222> (229)..(229)
<223> S or T

<220>
<221> MOD_RES
<222> (230)..(230)
<223> D or E

<220>
<221> MOD_RES
<222> (232)..(232)
<223> S or T

<220>
<221> MOD_RES
<222> (233)..(233)
<223> S or T

<220>
<221> MOD_RES
<222> (234)..(234)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (235)..(235)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (237)..(237)
<223> D or E

<220>
<221> MOD_RES
<222> (238)..(238)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (240)..(240)
<223> S or T

<220>
<221> MOD_RES
<222> (245)..(245)
<223> D or E

<220>
<221> MOD_RES
<222> (246)..(246)
<223> S or T

<220>
<221> MOD_RES
<222> (247)..(247)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (249)..(249)
<223> D or E

<220>
<221> MOD_RES
<222> (252)..(252)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (256)..(256)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (257)..(257)
<223> D or E

<220>
<221> MOD_RES
<222> (259)..(259)
<223> S or T

<220>
<221> MOD_RES
<222> (260)..(260)
<223> S or T

<220>
<221> MOD_RES
<222> (263)..(263)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (264)..(264)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (265)..(265)
<223> S or T

<220>
<221> MOD_RES
<222> (266)..(266)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (267)..(267)
<223> D or E

<220>
<221> MOD_RES
<222> (268)..(268)
<223> S or T

<220>
<221> MOD_RES
<222> (275)..(275)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (285)..(285)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (286)..(286)
<223> D or E

<220>
<221> MOD_RES
<222> (288)..(288)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (289)..(289)
<223> D or E

<220>
<221> MOD_RES
<222> (292)..(292)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (294)..(294)
<223> D or E

<220>
<221> MOD_RES
<222> (301)..(301)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (310)..(310)
<223> D or E

<220>
<221> MOD_RES
<222> (319)..(319)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (321)..(321)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (332)..(332)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (334)..(334)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (335)..(335)
<223> S or T

<220>
<221> MOD_RES
<222> (338)..(338)
<223> S or T

<220>
<221> MOD_RES
<222> (339)..(339)
<223> D or E

<220>
<221> MOD_RES
<222> (340)..(340)
<223> D or E

<220>
<221> MOD_RES
<222> (341)..(341)
<223> D or E

<220>
<221> MOD_RES
<222> (344)..(344)
<223> R, K, or H

<400> 8
Met Thr Glu Xaa Val Leu Phe Ser Xaa Xaa Xaa Asn Gly Val Ala Xaa 
1               5                   10                  15      


Ile Thr Leu Asn Arg Pro Lys Ala Leu Asn Ser Leu Ser Tyr Xaa Met 
            20                  25                  30          


Leu Gln Pro Ile Gly Gln Lys Leu Lys Glu Trp Glu Xaa Xaa Xaa Xaa 
        35                  40                  45              


Ile Ala Xaa Ile Val Leu Lys Gly Ala Gly Xaa Lys Gly Phe Cys Ala 
    50                  55                  60                  


Gly Gly Asp Ile Lys Thr Leu Tyr Glu Ala Arg Ser Asn Glu Xaa Ala 
65                  70                  75                  80  


Leu Gln Xaa Ala Glu Xaa Phe Phe Xaa Glu Xaa Tyr Xaa Ile Asp Thr 
                85                  90                  95      


Tyr Xaa Tyr Gln Tyr Xaa Lys Pro Ile Ile Ala Cys Leu Asp Gly Ile 
            100                 105                 110         


Val Met Gly Gly Gly Val Gly Leu Thr Asn Gly Ala Xaa Tyr Arg Ile 
        115                 120                 125             


Val Thr Xaa Xaa Thr Lys Trp Ala Met Pro Glu Met Asn Ile Gly Phe 
    130                 135                 140                 


Phe Pro Asp Val Gly Ala Ala Tyr Phe Leu Asn Xaa Ala Pro Gly Tyr 
145                 150                 155                 160 


Xaa Gly Xaa Tyr Val Ala Leu Xaa Ala Xaa Xaa Leu Lys Ala Xaa Asp 
                165                 170                 175     


Val Leu Phe Ile Asn Ala Ala Asp Tyr Phe Met Xaa Xaa Xaa Xaa Leu 
            180                 185                 190         


Pro Xaa Phe Leu Xaa Xaa Xaa Xaa Xaa Xaa Asn Trp Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Val Xaa Xaa Xaa Leu Lys Xaa Xaa Xaa Xaa Xaa Phe Ala Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Glu Xaa Xaa Asn Xaa 
225                 230                 235                 240 


His Phe Ala Phe Xaa Xaa Xaa Glu Xaa Ile Ile Xaa Ser Leu Glu Xaa 
                245                 250                 255     


Xaa Gln Xaa Xaa Phe Ala Xaa Xaa Xaa Xaa Xaa Xaa Leu Leu Ser Lys 
            260                 265                 270         


Ser Pro Xaa Ser Leu Lys Val Thr Leu Lys Gln Phe Xaa Xaa Gly Xaa 
        275                 280                 285             


Xaa Lys Ser Xaa Glu Xaa Cys Phe Ala Thr Asp Leu Xaa Leu Ala Lys 
    290                 295                 300                 


Asn Phe Met Arg His Xaa Asp Phe Phe Glu Gly Val Arg Ser Xaa Val 
305                 310                 315                 320 


Xaa Asp Lys Asp Gln Asn Pro Asn Tyr Lys Tyr Xaa Gln Xaa Xaa Asp 
                325                 330                 335     


Val Xaa Xaa Xaa Xaa Val Asn Xaa Phe Phe Asn Leu Leu Asn Ala 
            340                 345                 350     


<210> 9
<211> 370
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (4)..(4)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (7)..(7)
<223> D or E

<220>
<221> MOD_RES
<222> (8)..(8)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (9)..(9)
<223> S or T

<220>
<221> MOD_RES
<222> (10)..(10)
<223> S or T

<220>
<221> MOD_RES
<222> (11)..(11)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (12)..(12)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (18)..(18)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (20)..(20)
<223> S or T

<220>
<221> MOD_RES
<222> (24)..(24)
<223> D or E

<220>
<221> MOD_RES
<222> (25)..(25)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (26)..(26)
<223> S or T

<220>
<221> MOD_RES
<222> (31)..(31)
<223> S or T

<220>
<221> MOD_RES
<222> (36)..(36)
<223> D or E

<220>
<221> MOD_RES
<222> (37)..(37)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (40)..(40)
<223> D or E

<220>
<221> MOD_RES
<222> (41)..(41)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (42)..(42)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (43)..(43)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (47)..(47)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (48)..(48)
<223> D or E

<220>
<221> MOD_RES
<222> (51)..(51)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (52)..(52)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (55)..(55)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (69)..(69)
<223> D or E

<220>
<221> MOD_RES
<222> (71)..(71)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (72)..(72)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (74)..(74)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (75)..(75)
<223> D or E

<220>
<221> MOD_RES
<222> (78)..(78)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (79)..(79)
<223> D or E

<220>
<221> MOD_RES
<222> (80)..(80)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (83)..(83)
<223> D or E

<220>
<221> MOD_RES
<222> (84)..(84)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (90)..(90)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (94)..(94)
<223> D or E

<220>
<221> MOD_RES
<222> (95)..(95)
<223> A, D, R, H, K, S, T, N, Q, or Y

<220>
<221> MOD_RES
<222> (99)..(99)
<223> D or E

<220>
<221> MOD_RES
<222> (100)..(100)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (101)..(101)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (102)..(102)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (104)..(104)
<223> S or T

<220>
<221> MOD_RES
<222> (109)..(109)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (110)..(110)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (116)..(116)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (118)..(118)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (125)..(125)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (129)..(129)
<223> S or T

<220>
<221> MOD_RES
<222> (130)..(130)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (136)..(136)
<223> S or T

<220>
<221> MOD_RES
<222> (137)..(137)
<223> S or T

<220>
<221> MOD_RES
<222> (144)..(144)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (145)..(145)
<223> S or T

<220>
<221> MOD_RES
<222> (159)..(159)
<223> S or T

<220>
<221> MOD_RES
<222> (161)..(161)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (164)..(164)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (169)..(169)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (172)..(172)
<223> S or T

<220>
<221> MOD_RES
<222> (175)..(175)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (176)..(176)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (179)..(179)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (182)..(182)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (185)..(185)
<223> D or E

<220>
<221> MOD_RES
<222> (191)..(191)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (192)..(192)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (193)..(193)
<223> D or E

<220>
<221> MOD_RES
<222> (194)..(194)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (197)..(197)
<223> D or E

<220>
<221> MOD_RES
<222> (198)..(198)
<223> D or E

<220>
<221> MOD_RES
<222> (200)..(200)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (201)..(201)
<223> D or E

<220>
<221> MOD_RES
<222> (202)..(202)
<223> D or E

<220>
<221> MOD_RES
<222> (204)..(204)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (206)..(206)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (212)..(212)
<223> S or T

<220>
<221> MOD_RES
<222> (213)..(213)
<223> D or E

<220>
<221> MOD_RES
<222> (214)..(214)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (217)..(217)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (220)..(220)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (221)..(221)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (223)..(223)
<223> D or E

<220>
<221> MOD_RES
<222> (224)..(224)
<223> D or E

<220>
<221> MOD_RES
<222> (225)..(225)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (226)..(226)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (228)..(228)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (229)..(229)
<223> D or E

<220>
<221> MOD_RES
<222> (230)..(230)
<223> D or E

<220>
<221> MOD_RES
<222> (231)..(231)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (233)..(233)
<223> D or E

<220>
<221> MOD_RES
<222> (236)..(236)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (242)..(242)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (243)..(243)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (245)..(245)
<223> D or E

<220>
<221> MOD_RES
<222> (246)..(246)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (249)..(249)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (251)..(251)
<223> D or E

<220>
<221> MOD_RES
<222> (252)..(252)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (254)..(254)
<223> S or T

<220>
<221> MOD_RES
<222> (257)..(257)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (259)..(259)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (260)..(260)
<223> D or E

<220>
<221> MOD_RES
<222> (262)..(262)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (263)..(263)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (264)..(264)
<223> D or E

<220>
<221> MOD_RES
<222> (265)..(265)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (266)..(266)
<223> D or E

<220>
<221> MOD_RES
<222> (270)..(270)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (272)..(272)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (275)..(275)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (276)..(276)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (277)..(277)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (278)..(278)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (279)..(279)
<223> D or E

<220>
<221> MOD_RES
<222> (283)..(283)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (284)..(284)
<223> S or T

<220>
<221> MOD_RES
<222> (286)..(286)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (287)..(287)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (290)..(290)
<223> D or E

<220>
<221> MOD_RES
<222> (292)..(292)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (293)..(293)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (297)..(297)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (302)..(302)
<223> D or E

<220>
<221> MOD_RES
<222> (303)..(303)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (305)..(305)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (309)..(309)
<223> S or T

<220>
<221> MOD_RES
<222> (310)..(310)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (319)..(319)
<223> D or E

<220>
<221> MOD_RES
<222> (321)..(321)
<223> S or T

<220>
<221> MOD_RES
<222> (329)..(329)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (331)..(331)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (333)..(333)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (336)..(336)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (338)..(338)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (341)..(341)
<223> D or E

<220>
<221> MOD_RES
<222> (342)..(342)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (345)..(345)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (347)..(347)
<223> D or E

<220>
<221> MOD_RES
<222> (349)..(349)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (350)..(350)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (351)..(351)
<223> D or E

<220>
<221> MOD_RES
<222> (355)..(355)
<223> D or E

<220>
<221> MOD_RES
<222> (356)..(356)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (357)..(357)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (359)..(359)
<223> D or E

<220>
<221> MOD_RES
<222> (361)..(361)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (362)..(362)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (364)..(364)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (366)..(366)
<223> D or E

<220>
<221> MOD_RES
<222> (367)..(367)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (368)..(368)
<223> S or T

<220>
<221> MOD_RES
<222> (369)..(369)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (370)..(370)
<223> Any amino acid 

<400> 9
Met Asn Xaa Xaa Phe Glu Xaa Xaa Xaa Xaa Xaa Xaa Gly Ala Arg Ile 
1               5                   10                  15      


Gly Xaa Ala Xaa Leu Asp Ala Xaa Xaa Xaa Leu Asn Ala Leu Xaa Leu 
            20                  25                  30          


Pro Met Ile Xaa Xaa Leu Gly Xaa Xaa Xaa Xaa Ala Trp Ala Xaa Xaa 
        35                  40                  45              


Pro Gly Xaa Xaa Cys Val Xaa Leu Arg Gly Asn Gly Ala Lys Ala Phe 
    50                  55                  60                  


Cys Ala Gly Gly Xaa Val Xaa Xaa Leu Xaa Xaa Ala Cys Xaa Xaa Xaa 
65                  70                  75                  80  


Pro Gly Xaa Xaa Pro Pro Leu Ala Ala Xaa Phe Phe Ala Xaa Xaa Tyr 
                85                  90                  95      


Arg Leu Xaa Xaa Xaa Xaa His Xaa Tyr Pro Lys Pro Xaa Xaa Cys Trp 
            100                 105                 110         


Gly His Gly Xaa Val Xaa Gly Gly Gly Met Gly Leu Xaa Gln Gly Ala 
        115                 120                 125             


Xaa Xaa Arg Ile Val Thr Pro Xaa Xaa Arg Leu Ala Met Pro Glu Xaa 
    130                 135                 140                 


Xaa Ile Gly Leu Tyr Pro Asp Val Gly Ala Ser Trp Phe Leu Xaa Arg 
145                 150                 155                 160 


Xaa Pro Gly Xaa Leu Gly Leu Phe Xaa Gly Leu Xaa Gly Ala Xaa Xaa 
                165                 170                 175     


Asn Ala Xaa Asp Ala Xaa Asp Leu Xaa Leu Ala Asp Arg Phe Xaa Xaa 
            180                 185                 190         


Xaa Xaa Gln Gln Xaa Xaa Leu Xaa Xaa Xaa Leu Xaa Gln Xaa Asn Trp 
        195                 200                 205             


Gln Glu Gln Xaa Xaa Xaa Gln Leu Xaa Ser Leu Xaa Xaa Ala Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Ala Xaa Xaa Xaa Xaa Pro Xaa Ala Gln Xaa Leu Pro Arg Arg 
225                 230                 235                 240 


Gln Xaa Xaa Asp Xaa Xaa Leu Asp Xaa Ala Xaa Xaa Ala Xaa Ala Trp 
                245                 250                 255     


Xaa Ala Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Asp Pro Leu Xaa Ala Xaa 
            260                 265                 270         


Ala Ala Xaa Xaa Xaa Xaa Xaa Gly Cys Pro Xaa Xaa Ala Xaa Xaa Val 
        275                 280                 285             


Trp Xaa Gln Xaa Xaa Arg Ala Arg Xaa Leu Ser Leu Ala Xaa Xaa Phe 
    290                 295                 300                 


Xaa Met Glu Tyr Xaa Xaa Ser Leu Asn Cys Cys Arg His Pro Xaa Phe 
305                 310                 315                 320 


Xaa Glu Gly Val Arg Ala Arg Leu Xaa Asp Xaa Asp Xaa Gln Pro Xaa 
                325                 330                 335     


Trp Xaa Trp Pro Xaa Xaa Ala Gln Xaa Pro Xaa Ala Xaa Xaa Xaa Ala 
            340                 345                 350         


His Phe Xaa Xaa Xaa Trp Xaa Gly Xaa Xaa Pro Xaa Ala Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa 
    370 


<210> 10
<211> 374
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (9)..(9)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (10)..(10)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (12)..(12)
<223> S or T

<220>
<221> MOD_RES
<222> (13)..(13)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (18)..(18)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (22)..(22)
<223> S or T

<220>
<221> MOD_RES
<222> (27)..(27)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (33)..(33)
<223> S or T

<220>
<221> MOD_RES
<222> (37)..(37)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (40)..(40)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (43)..(43)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (44)..(44)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (45)..(45)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (50)..(50)
<223> D or E

<220>
<221> MOD_RES
<222> (53)..(53)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (56)..(56)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (57)..(57)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (59)..(59)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (64)..(64)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (71)..(71)
<223> D or E

<220>
<221> MOD_RES
<222> (72)..(72)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (73)..(73)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (74)..(74)
<223> S or T

<220>
<221> MOD_RES
<222> (75)..(75)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (77)..(77)
<223> D or E

<220>
<221> MOD_RES
<222> (85)..(85)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (96)..(96)
<223> D or E

<220>
<221> MOD_RES
<222> (97)..(97)
<223> A, D, R, H, K, S, T, N, Q, or Y

<220>
<221> MOD_RES
<222> (100)..(100)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (101)..(101)
<223> D or E

<220>
<221> MOD_RES
<222> (104)..(104)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (111)..(111)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (112)..(112)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (119)..(119)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (133)..(133)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (134)..(134)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (135)..(135)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (139)..(139)
<223> S or T

<220>
<221> MOD_RES
<222> (140)..(140)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (162)..(162)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (171)..(171)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (174)..(174)
<223> S or T

<220>
<221> MOD_RES
<222> (178)..(178)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (184)..(184)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (186)..(186)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (190)..(190)
<223> D or E

<220>
<221> MOD_RES
<222> (196)..(196)
<223> D or E

<220>
<221> MOD_RES
<222> (202)..(202)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (205)..(205)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (208)..(208)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (215)..(215)
<223> D or E

<220>
<221> MOD_RES
<222> (216)..(216)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (227)..(227)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (237)..(237)
<223> D or E

<220>
<221> MOD_RES
<222> (240)..(240)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (247)..(247)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (256)..(256)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (263)..(263)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (266)..(266)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (269)..(269)
<223> D or E

<220>
<221> MOD_RES
<222> (281)..(281)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (285)..(285)
<223> S or T

<220>
<221> MOD_RES
<222> (287)..(287)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (288)..(288)
<223> S or T

<220>
<221> MOD_RES
<222> (290)..(290)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (291)..(291)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (303)..(303)
<223> S or T

<220>
<221> MOD_RES
<222> (304)..(304)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (306)..(306)
<223> D or E

<220>
<221> MOD_RES
<222> (311)..(311)
<223> D or E

<220>
<221> MOD_RES
<222> (314)..(314)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (320)..(320)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (321)..(321)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (323)..(323)
<223> D or E

<220>
<221> MOD_RES
<222> (328)..(328)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (329)..(329)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (332)..(332)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (333)..(333)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (335)..(335)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (336)..(336)
<223> D or E

<220>
<221> MOD_RES
<222> (342)..(342)
<223> R, K, or H

<220>
<221> MOD_RES
<222> (346)..(346)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (349)..(349)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (351)..(351)
<223> D or E

<220>
<221> MOD_RES
<222> (354)..(354)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (361)..(361)
<223> I, L, or V

<220>
<221> MOD_RES
<222> (365)..(365)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (372)..(372)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (373)..(373)
<223> Any amino acid 

<220>
<221> MOD_RES
<222> (374)..(374)
<223> Any amino acid 

<400> 10
Xaa Xaa Met Xaa Met Thr Glu His Xaa Xaa Phe Xaa Xaa Ser Glu Asn 
1               5                   10                  15      


Gly Xaa Ala Ser Ile Xaa Leu Asn Arg Pro Xaa Ala Leu Asn Ser Leu 
            20                  25                  30          


Xaa Tyr Asp Met Xaa Gln Pro Xaa Gly Gln Xaa Xaa Xaa Glu Trp Glu 
        35                  40                  45              


Asn Xaa Glu Arg Xaa Ala Leu Xaa Xaa Leu Xaa Gly Ala Gly Thr Xaa 
    50                  55                  60                  


Gly Phe Cys Ala Gly Gly Xaa Xaa Xaa Xaa Xaa Tyr Xaa Ala Arg Ser 
65                  70                  75                  80  


Asn Glu Pro Gly Xaa Ala Leu Gln His Ala Glu Arg Phe Phe Glu Xaa 
                85                  90                  95      


Xaa Tyr Glu Xaa Xaa Thr Tyr Xaa Tyr Gln Tyr Lys Lys Pro Xaa Xaa 
            100                 105                 110         


Ala Cys Leu Asp Gly Ile Xaa Met Gly Gly Gly Val Gly Leu Thr Asn 
        115                 120                 125             


Gly Ala Lys Tyr Xaa Xaa Xaa Thr Glu Arg Xaa Xaa Trp Ala Met Pro 
    130                 135                 140                 


Glu Met Asn Ile Gly Phe Phe Pro Asp Val Gly Ala Ala Tyr Phe Leu 
145                 150                 155                 160 


Asn Xaa Ala Pro Gly Tyr Leu Gly Arg Tyr Xaa Ala Leu Xaa Ala Ser 
                165                 170                 175     


Ile Xaa Lys Ala Ser Asp Val Xaa Phe Xaa Asn Ala Ala Xaa Tyr Phe 
            180                 185                 190         


Met Thr Ser Xaa Ser Leu Pro Ala Phe Xaa Thr Glu Xaa Glu Ser Xaa 
        195                 200                 205             


Asn Trp His Lys Glu Asp Xaa Xaa His Thr His Leu Leu Lys Glu Xaa 
    210                 215                 220                 


Xaa Val Xaa Arg Thr Phe Ala Thr Ala Pro Asn Leu Xaa Ser Glu Xaa 
225                 230                 235                 240 


Ala Pro Ser Leu Glu Glu Xaa Asn Ser His Phe Ala Phe Asp Thr Xaa 
                245                 250                 255     


Glu Glu Ile Trp Xaa Ala Xaa His Ser Xaa Glu Lys Xaa Gln Ser Ser 
            260                 265                 270         


Phe Ala Leu Lys Thr Lys Glu Thr Xaa Leu Ser Lys Xaa Pro Xaa Xaa 
        275                 280                 285             


Leu Xaa Xaa Thr Leu Lys Gln Phe Ile Asp Gly Arg Asp Lys Xaa Xaa 
    290                 295                 300                 


Glu Xaa Cys Phe Ala Thr Xaa Leu Val Xaa Ala Lys Asn Phe Met Xaa 
305                 310                 315                 320 


Xaa Glu Xaa Phe Phe Glu Gly Xaa Xaa Ser Val Xaa Xaa Asp Xaa Xaa 
                325                 330                 335     


Gln Asn Pro Asn Tyr Xaa Tyr Lys Gln Xaa Ser Asp Xaa Ser Xaa Glu 
            340                 345                 350         


Asp Xaa Asn Arg Phe Phe Asn Leu Xaa Asn Ala Gly Xaa His Pro Leu 
        355                 360                 365             


Ala Asp Leu Xaa Xaa Xaa 
    370                 


<210> 11
<211> 6801
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
atgagattgc agttgagaac cttgactaga aggtttttct ctatggcttc tggttcttct       60

actccagatg ttgctccatt ggttgatcca aatattcata agggtttggc ctctcacttt      120

ttcggtttga actctgttca tactgctaag ccatctaagg tcaaagaatt tgttgcttct      180

catggtggtc ataccgttat caacaaagtt ttgattgcca acaacggtat tgctgccgta      240

aaagaaatta ggtctgttag aaaatgggcc tacgaaactt ttggtgacga aagagctatt      300

tccttcactg ttatggctac acctgaagat ttggctgcta atgctgatta cattagaatg      360

gccgatcaat acgttgaagt tccaggtggt acaaacaaca acaattacgc taacgttgaa      420

ttgatcgttg atgtcgctga aagatttggt gttgatgctg tttgggctgg ttggggtcat      480

gcttctgaaa atccattatt gccagaatct ttggctgctt ctccaagaaa gatcgttttt      540

attggtccac caggtgctgc tatgagatca ttgggtgata agatttcttc taccatcgtt      600

gctcaacatg ctaaggttcc atgtattcca tggtctggta ctggtgttga tgaagttgtt      660

gttgataagt ccaccaactt ggtttccgtt tctgaagaag tttacactaa gggttgtact      720

actggtccaa aacaaggttt ggaaaaggct aagcaaattg gtttcccagt tatgattaag      780

gcttctgaag gtggtggtgg taaaggtatt agaaaggttg aaagggaaga agatttcgaa      840

gctgcttacc atcaagttga aggtgaaatt ccaggttccc caattttcat tatgcaattg      900

gctggtaacg ccagacattt ggaagttcaa ttattggctg atcagtacgg caacaacatt      960

tctttgtttg gtagagattg ctccgttcaa agaaggcatc aaaagattat tgaagaagcc     1020

ccagttactg ttgctggtca acaaactttt actgctatgg aaaaagctgc cgtcagattg     1080

ggtaaattgg ttggttatgt ttctgccggt actgtcgaat acttgtactc tcatgaagat     1140

gacaagttct acttcttgga attgaaccca agattgcaag ttgaacatcc aactactgaa     1200

atggttaccg gtgttaattt gccagctgct caattgcaaa ttgctatggg tattccattg     1260

gacagaatca aggatattag gttgttctac ggtgttaacc cacataccac tactccaatt     1320

gatttcgatt tctctggtga agatgctgac aaaactcaaa gaaggccagt tccaagaggt     1380

catacaactg cttgtagaat tacttctgaa gatccaggtg aaggttttaa accatctggt     1440

ggtactatgc acgaattgaa ctttaggtcc tcttctaatg tttggggtta cttctctgtt     1500

ggtaatcaag gtggtatcca ctctttctct gattctcaat tcggtcatat tttcgccttt     1560

ggtgaaaaca gatccgcctc aagaaaacat atggttgttg ccttgaaaga attgtccatc     1620

agaggtgatt tcagaaccac tgttgaatac ttgatcaaat tattggaaac cccagacttc     1680

gaggataaca ctattactac tggttggttg gacgagttga tctctaacaa attgactgct     1740

gaaagaccag attccttctt ggctgttgtt tgtggtgctg ctacaaaagc tcatagagct     1800

tcagaagatt ctatcgctac ttacatggct tctttggaaa aaggtcaagt tccagccaga     1860

gacattttga aaactttgtt cccagttgac ttcatctacg aaggtcaaag atacaagttt     1920

accgctacca gatcatccga agattcttac actttgttca tcaacggttc cagatgcgat     1980

attggtgtta gaccattgtc tgatggtggt attttgtgtt tggttggtgg tagatcccat     2040

aacgtttatt ggaaagaaga agttggcgct accagattgt ctgttgattc taaaacttgc     2100

ttgttggaag tcgaaaacga tccaactcaa ttgagatcac catctccagg taagttggtt     2160

aagttcttgg ttgaaaacgg tgatcacgtt agagctaatc aaccatacgc tgaaatcgaa     2220

gtcatgaaga tgtacatgac tttgaccgct caagaagatg gtatcgttca attgatgaag     2280

caaccaggtt ctactattga agccggtgat attttgggta ttttggcttt ggatgatcca     2340

tccaaggtca aacatgctaa accatttgaa ggtcagttgc cagaattggg tccaccaaca     2400

ttgtctggta acaaaccaca tcaaagatac gaacattgcc aaaacgtctt gcacaacatt     2460

ttgttgggtt tcgataacca ggttgtcatg aagtctacat tgcaagaaat ggtcggtttg     2520

ttgagaaatc cagaattgcc atacttgcaa tgggctcatc aagtttcttc attgcataca     2580

agaatgtccg ctaagttgga tgctactttg gctggtttga ttgataaggc taaacaaagg     2640

ggtggtgaat ttccagctaa gcaattattg agagccttgg aaaaagaagc ttcatctggc     2700

gaagttgatg ctttgtttca acaaacattg gcccctttgt ttgatttggc tagagaatat     2760

caagatggtt tggccatcca tgaattgcaa gttgctgctg gtttgttgca agcttattat     2820

gattctgaag ctagattctg cggtccaaac gttagagatg aagatgttat cttgaagttg     2880

agggaagaaa acagggactc tttgagaaaa gttgttatgg cccaattgtc ccattcaaga     2940

gttggtgcta aaaacaactt ggttttggct ttgttggatg agtacaaggt tgctgatcaa     3000

gctggtactg attctccagc ttctaatgtt catgttgcta aatacttgag gccagtcttg     3060

agaaagattg tcgaattgga atcaagagct tccgctaagg tttctttgaa ggctagagaa     3120

attttgatcc aatgcgcttt gccatccttg aaagaaagaa ctgatcaatt ggaacacatc     3180

ttgagatcct ctgttgttga atcaagatac ggtgaagttg gtttggaaca tagaactcca     3240

agagctgaca tcttgaaaga agttgttgac tccaagtaca tcgtgttcga tgttttggct     3300

caattcttcg ctcatgatga tccatggata gttttggctg ctttggagtt gtatattaga     3360

agggcttgta aggcctactc cattttggat attaactacc accaagactc tgatttgcca     3420

ccagttattt cttggagatt cagattgcca actatgtcat ctgccttgta caactctgtt     3480

gtttcttctg gttctaagac tccaacttct ccatctgttt caagagctga ttctgtttcc     3540

gatttctctt acaccgttga aagagattct gctccagcta gaactggtgc tatagttgct     3600

gttccacatt tggatgattt ggaagatgct ttgaccagag tcttggaaaa tttgccaaaa     3660

agaggtgctg gtttggctat ttctgttggt gcttctaaca aatcagctgc tgcttctgct     3720

agagatgctg ctgctgcagc tgcttcttct gttgatactg gtttgtctaa catctgcaac     3780

gttatgatcg gtagagttga tgaatccgat gatgatgata ccttgatcgc cagaatttcc     3840

caagttatcg aagatttcaa agaggacttc gaagcttgct ccttgagaag aattactttc     3900

tcattcggta actccagagg tacttaccca aagtacttta cttttagagg tccagcctat     3960

gaagaagatc caaccattag acatattgaa ccagctttgg cctttcaatt ggaattggct     4020

agattgtcta acttcgacat caagccagtt cataccgata acagaaacat ccatgtttac     4080

gaagctactg gtaagaatgc tgcttccgat aagagatttt tcaccagagg tatagttaga     4140

ccaggtagat tgagagaaaa catcccaaca tccgagtact tgatttctga agctgataga     4200

ttgatgtccg atattttgga tgccttggaa gttattggta ctaccaactc tgatttgaac     4260

cacatcttca ttaacttctc cgctgttttt gctttgaagc cagaagaagt tgaagctgct     4320

tttggtggtt ttttggaaag attcggtaga agattgtgga gattgagagt tactggtgcc     4380

gaaattagaa tgatggtttc tgatccagaa actggttctg cttttccatt gagagctatg     4440

atcaacaacg tttccggtta cgttgtccaa tctgaattat acgctgaagc caagaatgat     4500

aagggtcaat ggatctttaa gtccttgggt aaaccaggtt caatgcatat gagatccatt     4560

aacactccat accctaccaa agaatggttg caacctaaaa gatacaaggc ccatttgatg     4620

ggtactacct actgttatga tttcccagag ttgttcagac agtccattga atctgattgg     4680

aaaaagtacg atggtaaggc tccagatgat ttgatgactt gcaacgaatt gatcttggac     4740

gaagattctg gtgaattgca agaagttaat agagaaccag gtgctaacaa cgttggtatg     4800

gttgcttgga aatttgaagc taagactcca gaatatccaa ggggtagaag ttttatcgtt     4860

gttgccaacg atattacctt ccagattggt tcttttggtc cagctgaaga tcaattcttc     4920

ttcaaggtta ctgaattggc cagaaagttg ggtattccaa gaatctactt gtctgctaat     4980

tccggtgcta gaattggtat tgctgatgaa ttggtcggta agtacaaagt tgcttggaat     5040

gacgaaactg atccatctaa gggtttcaag tacttgtact tcactccaga atcattggct     5100

accttgaaac cagatactgt tgttaccacc gaaattgaag aagaaggtcc aaacggcgtt     5160

gaaaagagac atgttattga ttacatcgtc ggtgaaaagg atggtttggg tgttgaatgt     5220

ttgagaggtt ctggtttaat tgctggtgct acttcaagag cttacaagga tattttcacc     5280

ttgaccttgg ttacctgtag atcagttggt attggtgctt acttggttag attgggtcaa     5340

agagccattc aaattgaagg tcagccaatt atcttgactg gtgctccagc tattaacaag     5400

ttgttgggta gagaagtcta ctcctctaac ttgcaattgg gtggtactca aatcatgtac     5460

aacaacggtg tttctcattt gaccgctaga gatgatttga acggtgttca taagatcatg     5520

cagtggttgt cttatattcc agcttcaaga ggtttgccag ttccagtttt gccacataag     5580

actgatgttt gggatagaga tgttaccttc caaccagtta gaggtgaaca atatgatgtc     5640

agatggttga tttctggtag gactttggaa gatggtgctt ttgaatctgg tttgttcgat     5700

aaggactctt tccaagaaac tttatctggt tgggctaagg gtgttgttgt tggtagagct     5760

agattgggtg gtattccatt tggtgttatt ggtgttgaaa ctgccactgt tgataacact     5820

actccagctg atccagctaa tccagattct attgaaatgt ctacttccga agctggtcaa     5880

gtttggtatc caaattctgc tttcaagacc tcccaagcca ttaacgattt taatcatggt     5940

gaagccttgc cattgatgat tttggctaat tggagaggtt tttccggtgg tcaaagagat     6000

atgtacaacg aagttttgaa gtacggctcc tttattgtcg atgctttggt tgattacaag     6060

cagccaatta tggtttacat tccaccaact ggtgaattga gaggtggttc ttgggttgtt     6120

gttgacccaa ctattaactc cgatatgatg gaaatgtacg ccgatgttga aagtagaggt     6180

ggtgttttgg aaccagaagg tatggttggt attaagtaca gaagagacaa gttgttagat     6240

accatggcca gattagatcc agagtactct tccttgaaaa aacaattgga agagtcccca     6300

gactccgaag aattgaaagt taagttgtcc gtcagggaaa agtctttgat gccaatctac     6360

caacaaatct ccgttcaatt tgctgacttg catgatagag ctggtagaat ggaagctaaa     6420

ggtgttatta gagaagcctt ggtttggaag gatgctagaa gatttttctt ttggaggatc     6480

agaagaaggt tggtcgagga atatttgatc accaagatca actccatttt gccatcttgt     6540

accagattgg aatgtttggc tagaatcaaa tcttggaagc cagctacttt ggatcaaggt     6600

tctgatagag gtgttgctga atggtttgac gaaaattctg atgctgtttc tgccaggttg     6660

tctgaattga aaaaagatgc ttctgctcag tccttcgctt cccaattgag aaaagataga     6720

caaggtacat tgcagggtat gaagcaagct ttggcttctt tgtctgaagc tgaaagagct     6780

gaattattga agggcttgta a                                               6801


<210> 12
<211> 7891
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accacgcttt tcaattcaat tcatcatttt ttttttattc ttttttttga tttcggtttc      240

tttgaaattt ttttgattcg gtaatctccg aacagaagga agaacgaagg aaggagcaca      300

gacttagatt ggtatatata cgcatatgta gtgttgaaga aacatgaaat tgcccagtat      360

tcttaaccca actgcacaga acaaaaacct gcaggaaacg aagataaatc atgtcgaaag      420

ctacatataa ggaacgtgct gctactcatc ctagtcctgt tgctgccaag ctatttaata      480

tcatgcacga aaagcaaaca aacttgtgtg cttcattgga tgttcgtacc accaaggaat      540

tactggagtt agttgaagca ttaggtccca aaatttgttt actaaaaaca catgtggata      600

tcttgactga tttttccatg gagggcacag ttaagccgct aaaggcatta tccgccaagt      660

acaatttttt actcttcgaa gacagaaaat ttgctgacat tggtaataca gtcaaattgc      720

agtactctgc gggtgtatac agaatagcag aatgggcaga cattacgaat gcacacggtg      780

tggtgggccc aggtattgtt agcggtttga agcaggcggc agaagaagta acaaaggaac      840

ctagaggcct tttgatgtta gcagaattgt catgcaaggg ctccctatct actggagaat      900

atactaaggg tactgttgac attgcgaaga gcgacaaaga ttttgttatc ggctttattg      960

ctcaaagaga catgggtgga agagatgaag gttacgattg gttgattatg acacccggtg     1020

tgggtttaga tgacaaggga gacgcattgg gtcaacagta tagaaccgtg gatgatgtgg     1080

tctctacagg atctgacatt attattgttg gaagaggact atttgcaaag ggaagggatg     1140

ctaaggtaga gggtgaacgt tacagaaaag caggctggga agcatatttg agaagatgcg     1200

gccagcaaaa ctaaaaaact gtattataag taaatgcatg tatactaaac tcacaaatta     1260

gagcttcaat ttaattatat cagttattac cctgcggtgt gaaataccgc acagatgcgt     1320

aaggagaaaa taccgcatca ggaaattgta aacgttaata ttttgttaaa attcgcgtta     1380

aatttttgtt aaatcagctc attttttaac caataggccg aaatcggcaa aatcccttat     1440

aaatcaaaag aatagaccga gatagggttg agtgttgttc cagtttggaa caagagtcca     1500

ctattaaaga acgtggactc caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc     1560

ccactacgtg aaccatcacc ctaatcaagt tttttggggt cgaggtgccg taaagcacta     1620

aatcggaacc ctaaagggag cccccgattt agagcttgac ggggaaagcc ggcgaacgtg     1680

gcgagaaagg aagggaagaa agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg     1740

gtcacgctgc gcgtaaccac cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcg     1800

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg     1860

ctattacgcc agctggcgaa ggggggatgt gctgcaaggc gattaagttg ggtaacgcca     1920

gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattgtaata cgactcacta     1980

tagggcgaat tggagctcca ccgcggtggc ggccgcatag gccactagtg gatctgatat     2040

catcgatgaa ttcgagctcg ttttcgacac tggatggcgg cgttagtatc gaatcgacag     2100

cagtatagcg accagcattc acatacgatt gacgcatgat attactttct gcgcacttaa     2160

cttcgcatct gggcagatga tgtcgaggcg aaaaaaaata taaatcacgc taacatttga     2220

ttaaaataga acaactacaa tataaaaaaa ctatacaaat gacaagttct tgaaaacaag     2280

aatcttttta ttgtcagtac tgattattcc tttgccctcg gacgagtgct ggggcgtcgg     2340

tttccactat cggcgagtac ttctacacag ccatcggtcc agacggccgc gcttctgcgg     2400

gcgatttgtg tacgcccgac agtcccggct ccggatcgga cgattgcgtc gcatcgaccc     2460

tgcgcccaag ctgcatcatc gaaattgccg tcaaccaagc tctgatagag ttggtcaaga     2520

ccaatgcgga gcatatacgc ccggagccgc ggcgatcctg caagctccgg atgcctccgc     2580

tcgaagtagc gcgtctgctg ctccatacaa gccaaccacg gcctccagaa gaagatgttg     2640

gcgacctcgt attgggaatc cccgaacatc gcctcgctcc agtcaatgac cgctgttatg     2700

cggccattgt ccgtcaggac attgttggag ccgaaatccg cgtgcacgag gtgccggact     2760

tcggggcagt cctcggccca aagcatcagc tcatcgagag cctgcgcgac ggacgcactg     2820

acggtgtcgt ccatcacagt ttgccagtga tacacatggg gatcagcaat cgcgcatatg     2880

aaatcacgcc atgtagtgta ttgaccgatt ccttgcggtc cgaatgggcc gaacccgctc     2940

gtctggctaa gatcggccgc agcgatcgca tccatggcct ccgcgaccgg ctgcagaaca     3000

gcgggcagtt cggtttcagg caggtcttgc aacgtgacac cctgtgcacg gcgggagatg     3060

caataggtca ggctctcgct gaattcccca atgtcaagca cttccggaat cgggagcgcg     3120

gccgatgcaa agtgccgata aacataacga tctttgtaga aaccatcggc gcagctattt     3180

acccgcagga catatccacg ccctcctaca tcgaagctga aagcacgaga ttcttcgccc     3240

tccgagagct gcatcaggtc ggagacgctg tcgaactttt cgatcagaaa cttctcgaca     3300

gacgtcgcgg tgagttcagg ctttttaccc atggttgttt atgttcggat gtgatgtgag     3360

aactgtatcc tagcaagatt ttaaaaggaa gtatatgaaa gaagaacctc agtggcaaat     3420

cctaaccttt tatatttctc tacaggggcg cggcgtgggg acaattcaac gcgtctgtga     3480

ggggagcgtt tccctgctcg caggtctgca gcgaggagcc gtaatttttg cttcgcgccg     3540

tgcggccatc aaaatgtatg gatgcaaatg attatacatg gggatgtatg ggctaaatgt     3600

acgggcgaca gtcacatcat gcccctgagc tgcgcacgtc aagactgtca aggagggtat     3660

tctgggcctc catgtcgctg gccgggtgac ccggcgggga cgaggcaagc taaacagatc     3720

tcccgggtag tttaaacaat gaatgtcacc tttgaagaaa gagccagttt acacggttac     3780

agaatcggta tcgcatcctt agacgcccca gcatccttga acgctttgtc cttaccaatg     3840

attgatgctt tacaagacag attgagagct tgggcagaag atgcagacat agcctgtgtc     3900

ttgttacgtg gtaatggttc taaagcattt tgcgcaggtg gtgacgttgt ccaattagct     3960

aagaaatgtt tggcctcccc aggtgaagcc cctgaattgg ctgaaagatt tttcgctaga     4020

agttacagat tagatcatta tttgcacaca tacccaaagc ctttgatatg ctgggctcat     4080

ggtcacgttt taggtggtgg tatgggtttg ttacaaggtg ctggtattag aatagtcacc     4140

ccatcttcaa gattggcaat gcctgaaatc tctattggtt tatttccaga tgttggtggt     4200

tcccatttct taagtagatt gcctggtaaa ttgggtttat ttttcggttt aaccgcttca     4260

ccattgaatg ccagagatgc tttggactta aacttggctg atagattctt gttagatact     4320

caacaagacg cattgatcga tggtttgatc caattgaact ggagagaaca accagatttg     4380

caattgcatt ccttgttaaa ggctttagaa caacaagcaa gaagtgaatt accagctgca     4440

caatggttgc ctagaagaga aagattagac gccttgttag atcaagctac tttaccattg     4500

tcttggcaag ccttagcttc attggaaaac gatgaagacg cattgttagc caaagccgct     4560

aagactatgt tgggtggttc acctttaaca ggtcatttgg tctggggtca aattagaaga     4620

gctagacact tatctttggc acaagtattt caaatggaat acggcatgtc attgaattgt     4680

tgcagacatc cagaatttgc agaaggtgta agagccagat taatcgataa agaccacgct     4740

ccacattggc actggcctga cgtaaaccaa gttcctgaag ccgttattgc agcccatttt     4800

gcaccattag atgaccaccc tttagctgat ttggcataag tttaaactca tgtaattagt     4860

tatgtcacgc ttacattcac gccctccccc cacatccgct ctaaccgaaa aggaaggagt     4920

tagacaacct gaagtctagg tccctattta tttttttata gttatgttag tattaagaac     4980

gttatttata tttcaaattt ttcttttttt tctgtacaga cgcgtgtacg catgtaacat     5040

tatactgaaa accttgcttg agaaggtttt gggacgctcg aaggctttaa tttgcggcct     5100

ctagcagctt ttgttccctt tagtgagggt taatttcgag cttggcgtaa tcatggtcat     5160

agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata ggagccggaa     5220

gcataaagtg taaagcctgg ggtgcctaat gagtgaggta actcacatta attgcgttgc     5280

gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc     5340

aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact     5400

cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac     5460

ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa     5520

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc ggcccccctg     5580

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     5640

gataccaggc gttcccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     5700

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct caatgctcac     5760

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     5820

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     5880

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     5940

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga     6000

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     6060

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     6120

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     6180

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     6240

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     6300

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     6360

tatttcgttc atccatagtt gcctgactgc ccgtcgtgta gataactacg atacgggagg     6420

gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag     6480

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     6540

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     6600

ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt     6660

ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca     6720

tgttgtgaaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg     6780

ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat     6840

ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta     6900

tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca     6960

gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct     7020

taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat     7080

cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa     7140

agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt     7200

gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa     7260

ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctggg tccttttcat     7320

cacgtgctat aaaaataatt ataatttaaa ttttttaata taaatatata aattaaaaat     7380

agaaagtaaa aaaagaaatt aaagaaaaaa tagtttttgt tttccgaaga tgtaaaagac     7440

tctaggggga tcgccaacaa atactacctt ttatcttgct cttcctgctc tcaggtatta     7500

atgccgaatt gtttcatctt gtctgtgtag aagaccacac acgaaaatcc tgtgatttta     7560

cattttactt atcgttaatc gaatgtatat ctatttaatc tgcttttctt gtctaataaa     7620

tatatatgta aagtacgctt tttgttgaaa ttttttaaac ctttgtttat ttttttttct     7680

tcattccgta actcttctac cttctttatt tactttctaa aatccaaata caaaacataa     7740

aaataaataa acacagagta aattcccaaa ttattccatc attaaaagat acgaggcgcg     7800

tgtaagttac aggcaagcga tccgtcctaa gaaaccatta ttatcatgac attaacctat     7860

aaaaataggc gtatcacgag gccctttcgt c                                    7891


<210> 13
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
ccaatatata ataaaatatg gaggaatgcg atgctcagaa atacgctaaa atgtgcccaa       60


<210> 14
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
tgcctggaga tccttactcg agttggatcc ttatttccat cttaagccat cgttaacttc       60


<210> 15
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
ttttactgat gcgtattctt tgaattttca aatagca                                37


<210> 16
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
tcaaagaata cgcatcagta aaaaatttga tgga                                   34


<210> 17
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
ttttactgat gtttattctt tgaattttca aatagcaact t                           41


<210> 18
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
tcaaagaata aacatcagta aaaaatttga tggacttgg                              39


<210> 19
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
ttttactgat tcgtattctt tgaattttca aatagcaac                              39


<210> 20
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
tcaaagaata cgaatcagta aaaaatttga tggact                                 36


<210> 21
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
ccaatatata ataaaatatg gaggaatgcg atgtctacaa cacataacgt ccctc            55


<210> 22
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
tgcctggaga tccttactcg agttggatcc ttactcaaca ggtaaggcgc gag              53


<210> 23
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
ctaattacat gactcgaggt cgacggtatc gttatttcca tcttaagcca tcgttaactt       60

c                                                                       61


<210> 24
<211> 67
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
cattagaaag aaagcatagc aatctaatct aagtttaaaa caatgactac tcaaccccag       60

ctaaatg                                                                 67


<210> 25
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
gaaagcatag caatctaatc taagtttaaa acaatgaccg aacaagtctt attctcagta       60


<210> 26
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
ctaattacat gactcgaggt cgacggtatc gttaagcgtt caacaaattg aaaaatctg        59


<210> 27
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
gaaagcatag caatctaatc taagtttaaa acaatgaccg aacatgtatt attctcag         58


<210> 28
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
ctaattacat gactcgaggt cgacggtatc gttaagcgtt taacaaattg aaaaatc          57


<210> 29
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
gaaagcatag caatctaatc taagtttaaa acaatgagaa gatacatcag aggtggt          57


<210> 30
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
ctaattacat gactcgaggt cgacggtatc gttatgcagc gttcaacaaa ttgaaaa          57


<210> 31
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
gaaagcatag caatctaatc taagtttaaa acaatgaccg aacaagtctt attctcag         58


<210> 32
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
ctaattacat gactcgaggt cgacggtatc gttaagcgtt caacaaattg aaaaatct         58


<210> 33
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
gaaagcatag caatctaatc taagtttaaa acaatgaact tacaatttga agaaagacca       60


<210> 34
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
ctaattacat gactcgaggt cgacggtatc gttacaaatc agctaaaggg tgttcac          57


<210> 35
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
gaaagcatag caatctaatc taagtttaaa acaatgaact tacactttga agaattgac        59


<210> 36
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
ctaattacat gactcgaggt cgacggtatc gttagtagtc agacaaatct gctaaag          57


<210> 37
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
gaaagcatag caatctaatc taagtttaaa acaatgacaa tccactgtga agtattaac        59


<210> 38
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
ctaattacat gactcgaggt cgacggtatc gttaaccaac gtcagccaaa gggtg            55


<210> 39
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
gaaagcatag caatctaatc taagtttaaa acaatgaatg tcacctttga agaaagag         58


<210> 40
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
ctaattacat gactcgaggt cgacggtatc gttatgccaa atcagctaaa gggtg            55


<210> 41
<211> 4431
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
cgaaacccta tgctctgttg ttcggatttg aaattttaaa actacattaa tgtgttagtt       60

tttctttctt tctttctttg tcttgacgtg atttggactt ctgtcttgca ttcgcgtcca      120

ttcatctgac ccaatattcc ttttggtttt gttatcctta taaaaagaaa ggaagcttct      180

tagagggaaa aaaatgatga agagtaatgc caaaatataa ataaataaat aaatatgaaa      240

atcattttct atttttaata gaataagaag agcatcttaa gattacaatt tcaagaaata      300

gtttacacag tatatccaat aactccaata aactactttc ctatacaaat ttctatggtg      360

ggattaatag taaaacttct gtacttctct aattcaccaa gaaattaagg taaacatctg      420

gtaagcacta tccagctttt tgctattaca catatggctt ttctgcaatc atttcttccc      480

attttgtctc aagccgttag tcttgaaacc acaggcggag tagagttact tgatgcggta      540

ttttacatgc cttttttcac tgcaaaaaaa atgaaataca tatttacacg atttgcagga      600

cagtttacga tagtgagtat gcagaatagt taacaccttt gttttatcct tttgtgtctt      660

aattatatga tataaaggcg cctggcaaat tcccgtttta agagcttggt gagcgctagg      720

agtcactgcc aggtatcgtt tgaacacggc attagtcagg gaagtcataa cacagtcctt      780

tcccgcaatt ttctttttct attactcttg gcctcctcta gtacactcta tattttttta      840

tgcctcggta atgattttca tttttttttt tcccctagcg gatgactctt tttttttctt      900

agcgattggc attatcacat aatgaattat acattatata aagtaatgtg atttcttcga      960

agaatatact aaaaaatgag caggcaagat aaacgaaggc aaagatgaca gagcagaaag     1020

ccctagtaaa gcgtattaca aatgaaacca agattcagat tgcgatctct ttaaagggtg     1080

gtcccctagc gatagagcac tcgatcttcc cagaaaaaga ggcagaagca gtagcagaac     1140

aggccacaca atcgcaagtg attaacgtcc acacaggtat agggtttctg gaccatatga     1200

tacatgctct ggccaagcat tccggctggt cgctaatcgt tgagtgcatt ggtgacttac     1260

acatagacga ccatcacacc actgaagact gcgggattgc tctcggtcaa gcttttaaag     1320

aggccctact ggcgcgtgga gtaaaaaggt ttggatcagg atttgcgcct ttggatgagg     1380

cactttccag agcggtggta gatctttcga acaggccgta cgcagttgtc gaacttggtt     1440

tgcaaaggga gaaagtagga gatctctctt gcgagatgat cccgcatttt cttgaaagct     1500

ttgcagaggc tagcagaatt accctccacg ttgattgtct gcgaggcaag aatgatcatc     1560

accgtagtga gagtgcgttc aaggctcttg cggttgccat aagagaagcc acctcgccca     1620

atggtaccaa cgatgttccc tccaccaaag gtgttcttat gtagtgacac cgattattta     1680

aagctgcagc atacgatata tatacatgtg tatatatgta tacctatgaa tgtcagtaag     1740

tatgtatacg aacagtatga tactgaagat gacaaggtaa tgcatcattc tatacgtgtc     1800

attctgaacg aggcgcgctt tccttttttc tttttgcttt ttcttttttt ttctcttgaa     1860

ctcgacggat ctatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc     1920

aggaaattgt aaacgttaat attttgttaa aattcgcgtt aaatttttgt taaatcagct     1980

cattttttaa ccaataggcc gatagcttca aaatgtttct actccttttt tactcttcca     2040

gattttctcg gactccgcgc atcgccgtac cacttcaaaa cacccaagca cagcatacta     2100

aatttcccct ctttcttcct ctagggtgtc gttaattacc cgtactaaag gtttggaaaa     2160

gaaaaaagag accgcctcgt ttctttttct tcgtcgaaaa aggcaataaa aatttttatc     2220

acgtttcttt ttcttgaaaa tttttttttt gatttttttc tctttcgatg acctcccatt     2280

gatatttaag ttaataaacg gtcttcaatt tctcaagttt cagtttcatt tttcttgttc     2340

tattacaact ttttttactt cttgctcatt agaaagaaag catagcaatc taatctaagt     2400

ttaaaacaat gaatgtcacc tttgaagaaa gagccagttt acacggttac agaatcggta     2460

tcgcatcctt agacgcccca gcatccttga acgctttgtc cttaccaatg attgatgctt     2520

tacaagacag attgagagct tgggcagaag atgcagacat agcctgtgtc ttgttacgtg     2580

gtaatggttc taaagcattt tgcgcaggtg gtgacgttgt ccaattagct aagaaatgtt     2640

tggcctcccc aggtgaagcc cctgaattgg ctgaaagatt tttcgctaga agttacagat     2700

tagatcatta tttgcacaca tacccaaagc ctttgatatg ctgggctcat ggtcacgttt     2760

taggtggtgg tatgggtttg ttacaaggtg ctggtattag aatagtcacc ccatcttcaa     2820

gattggcaat gcctgaaatc tctattggtt tatttccaga tgttggtggt tcccatttct     2880

taagtagatt gcctggtaaa ttgggtttat ttttcggttt aaccgcttca ccattgaatg     2940

ccagagatgc tttggactta aacttggctg atagattctt gttagatact caacaagacg     3000

cattgatcga tggtttgatc caattgaact ggagagaaca accagatttg caattgcatt     3060

ccttgttaaa ggctttagaa caacaagcaa gaagtgaatt accagctgca caatggttgc     3120

ctagaagaga aagattagac gccttgttag atcaagctac tttaccattg tcttggcaag     3180

ccttagcttc attggaaaac gatgaagacg cattgttagc caaagccgct aagactatgt     3240

tgggtggttc acctttaaca ggtcatttgg tctggggtca aattagaaga gctagacact     3300

tatctttggc acaagtattt caaatggaat acggcatgtc attgaattgt tgcagacatc     3360

cagaatttgc agaaggtgta agagccagat taatcgataa agaccacgct ccacattggc     3420

actggcctga cgtaaaccaa gttcctgaag ccgttattgc agcccatttt gcaccattag     3480

atgaccaccc tttagctgat ttggcataac gataccgtcg acctcgagtc atgtaattag     3540

ttatgtcacg cttacattca cgccctcccc ccacatccgc tctaaccgaa aaggaaggag     3600

ttagacaacc tgaagtctag gtccctattt atttttttat agttatgtta gtattaagaa     3660

cgttatttat atttcaaatt tttctttttt ttctgtacag acgcgtgtac gcatgtaaca     3720

ttatactgaa aaccttgctt gagaaggttt tgggacgctc gaaggcttta atttgcggcc     3780

ataaagcagc cgctaccaaa cagacaagat tcagtatgta aggtaaatac ctttttgcac     3840

agttaaacta cccaaactta ttaaagcttg ataaattact gaaattccac ctttcagtta     3900

gattcaggcc tcatatagat tagatatagg gtacgtaaca ttctgtcaac caagttgttg     3960

gaatgaaagt ctaaaatgtc atctattcgg tagcactcat gttactagta tactgtcaca     4020

tgcggtgtaa cgtggggaca taaaacagac atcaaatata atggaagctg aaatgcaaag     4080

atcgataatg taataggaat gaaacatata aaacgaaagg agaagtaatg gtaatattag     4140

tatgtagaaa taccgattca attttgggga ttcttatatt ctcgagagaa tttctagtat     4200

aatctgtata cataatatta taggctttac caacaatgga atttcgacaa ttatcatatt     4260

attcaccaat taatcacaag ttggtaatga gtttgataac aagttacttt cttaacaacg     4320

ttagtatcgt caaaacactc ggttttactc gagcttgtag cacaataata ccgtgtagag     4380

ttctgtattg ttcttcttag tgcttgtata tgctcatccc gaccttccat t              4431


<210> 42
<211> 5356
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 42
accggagctt ggatatgata aacgaaatat tcttgaatcg tgagatcgcc tgttttcaaa       60

accgttggag gcagaaacaa ttttgtcaca agatgggcat tctaccccat ccttgctgta      120

ttattgtagt ctcgctttct tttatgctgg acaaatgaga ctactgcaca tttttatacg      180

ttcttggttt tttttaaagg tgtggtttcg gcattatcct gccgcacgtt tcttggataa      240

ttcatcctga ttctctattt taaacgcttc agcctatcag gatttggttt tgatacatac      300

tgcaagagtg tatctcggga acagtcattt attccgcaac aaacttaatt gcggaacgcg      360

ttaggcgatt tctagcatat atcaaatacc gttcgcgatt tcttctgggt tcgtctcttt      420

tcttttaaat acttattaac gtactcaaac aactacactt cgttgtatct cagaatgaga      480

tccctcagta tgacaataca tcattctaaa cgttcgtaaa acacatatga aacaacttta      540

taacaaagcg aacaaaatgg gcaacatgag atgaaactcc gcgtccctta gctgaactac      600

ccaaacgtac gaatgcctga acaattagtt tagatccgag attccgcgct tccatcattt      660

agtataatcc atattttata taatatatag gataagtaac agcccgcgaa tcgaggagaa      720

cttctagtat atccacatac ctaatattat tgccttatta aaaatggaat cccaacaatt      780

acatcaaaat ccacattctc ttcaaaatca attgtcctgt acttccttgt tcatgtgtgt      840

tcaaaaacgt tatatttata ggataattat actctatttc tcaacaagta attggttgtt      900

tggccgagcg gtctaaggcg cctgattcaa gaaatatctt gaccgcagtt aactgtggga      960

atactcaggt atcgtaagat gcaagagttc gaatctctta gcaaccatta tttttttcct     1020

caacataacg agaacacaca ggggcgctat cgcacagaat caaattcgat gactggaaat     1080

tttttgttaa tttcagaggt cgcctgacgc atataccttt ttcaactgaa aaattgggag     1140

aaaaaggaaa ggtgagaggc cggaaccggc ttttcatata gaatagagaa gcgttcatga     1200

ctaaatgctt gcatcacaat acttgaagtt gacaatatta tttaaggacc tattgttttt     1260

tccaataggt ggttagcaat cgtcttactt tctaactttt cttacctttt acatttcagc     1320

aatatatata tatatttcaa ggatatacca ttctaatgtc tgcccctatg tctgccccta     1380

agaagatcgt cgttttgcca ggtgaccacg ttggtcaaga aatcacagcc gaagccatta     1440

aggttcttaa agctatttct gatgttcgtt ccaatgtcaa gttcgatttc gaaaatcatt     1500

taattggtgg tgctgctatc gatgctacag gtgtcccact tccagatgag gcgctggaag     1560

cctccaagaa ggttgatgcc gttttgttag gtgctgtggc tggtcctaaa tggggtaccg     1620

gtagtgttag acctgaacaa ggtttactaa aaatccgtaa agaacttcaa ttgtacgcca     1680

acttaagacc atgtaacttt gcatccgact ctcttttaga cttatctcca atcaagccac     1740

aatttgctaa aggtactgac ttcgttgttg tcagagaatt agtgggaggt atttactttg     1800

gtaagagaaa ggaagacgat ggtgatggtg tcgcttggga tagtgaacaa tacaccgttc     1860

cagaagtgca aagaatcaca agaatggccg ctttcatggc cctacaacat gagccaccat     1920

tgcctatttg gtccttggat aaagctaatc ttttggcctc ttcaagatta tggagaaaaa     1980

ctgtggagga aaccatcaag aacgaattcc ctacattgaa ggttcaacat caattgattg     2040

attctgccgc catgatccta gttaagaacc caacccacct aaatggtatt ataatcacca     2100

gcaacatgtt tggtgatatc atctccgatg aagcctccgt tatcccaggt tccttgggtt     2160

tgttgccatc tgcgtccttg gcctctttgc cagacaagaa caccgcattt ggtttgtacg     2220

aaccatgcca cggttctgct ccagatttgc caaagaataa ggttgaccct atcgccacta     2280

tcttgtctgc tgcaatgatg ttgaaattgt cattgaactt gcctgaagaa ggtaaggcca     2340

ttgaagatgc agttaaaaag gttttggatg caggtatcag aactggtgat ttaggtggtt     2400

ccaacagtac caccgaagtc ggtgatgctg tcgccgaaga agttaagaaa atccttgctt     2460

aaaaagattc tcttttttta tgatatttgt acataaactt tataaatgaa attcataata     2520

gaaacgacac gaaattacaa aatggaatat gttcataggg tagacgaaac tatatacgca     2580

atctacatac atttatcaag aaggagaaaa aggaggatag taaaggaata caggtaagca     2640

aattgatact aatggctcaa cgtgataagg aaaaagaatt gcactttaac attaatattg     2700

acaaggagga gggcaccaca caaaaagtta ggtgtaacag aaaatcatga aactacgatt     2760

cctaatttga tattggagga ttttctctaa aaaaaaaaaa atacaacaaa taaaaaacac     2820

tcaatgacct gaccatttga tggagtttaa gtcaatacct tcttgaagca tttcccataa     2880

tggtgaaagt tccctcaaga attttactct gtcagaaacg gcctatagct tcaaaatgtt     2940

tctactcctt ttttactctt ccagattttc tcggactccg cgcatcgccg taccacttca     3000

aaacacccaa gcacagcata ctaaatttcc cctctttctt cctctagggt gtcgttaatt     3060

acccgtacta aaggtttgga aaagaaaaaa gagaccgcct cgtttctttt tcttcgtcga     3120

aaaaggcaat aaaaattttt atcacgtttc tttttcttga aaattttttt tttgattttt     3180

ttctctttcg atgacctccc attgatattt aagttaataa acggtcttca atttctcaag     3240

tttcagtttc atttttcttg ttctattaca acttttttta cttcttgctc attagaaaga     3300

aagcatagca atctaatcta agtttaaaac aatgaatgtc acctttgaag aaagagccag     3360

tttacacggt tacagaatcg gtatcgcatc cttagacgcc ccagcatcct tgaacgcttt     3420

gtccttacca atgattgatg ctttacaaga cagattgaga gcttgggcag aagatgcaga     3480

catagcctgt gtcttgttac gtggtaatgg ttctaaagca ttttgcgcag gtggtgacgt     3540

tgtccaatta gctaagaaat gtttggcctc cccaggtgaa gcccctgaat tggctgaaag     3600

atttttcgct agaagttaca gattagatca ttatttgcac acatacccaa agcctttgat     3660

atgctgggct catggtcacg ttttaggtgg tggtatgggt ttgttacaag gtgctggtat     3720

tagaatagtc accccatctt caagattggc aatgcctgaa atctctattg gtttatttcc     3780

agatgttggt ggttcccatt tcttaagtag attgcctggt aaattgggtt tatttttcgg     3840

tttaaccgct tcaccattga atgccagaga tgctttggac ttaaacttgg ctgatagatt     3900

cttgttagat actcaacaag acgcattgat cgatggtttg atccaattga actggagaga     3960

acaaccagat ttgcaattgc attccttgtt aaaggcttta gaacaacaag caagaagtga     4020

attaccagct gcacaatggt tgcctagaag agaaagatta gacgccttgt tagatcaagc     4080

tactttacca ttgtcttggc aagccttagc ttcattggaa aacgatgaag acgcattgtt     4140

agccaaagcc gctaagacta tgttgggtgg ttcaccttta acaggtcatt tggtctgggg     4200

tcaaattaga agagctagac acttatcttt ggcacaagta tttcaaatgg aatacggcat     4260

gtcattgaat tgttgcagac atccagaatt tgcagaaggt gtaagagcca gattaatcga     4320

taaagaccac gctccacatt ggcactggcc tgacgtaaac caagttcctg aagccgttat     4380

tgcagcccat tttgcaccat tagatgacca ccctttagct gatttggcat aacgataccg     4440

tcgacctcga gtcatgtaat tagttatgtc acgcttacat tcacgccctc cccccacatc     4500

cgctctaacc gaaaaggaag gagttagaca acctgaagtc taggtcccta tttatttttt     4560

tatagttatg ttagtattaa gaacgttatt tatatttcaa atttttcttt tttttctgta     4620

cagacgcgtg tacgcatgta acattatact gaaaaccttg cttgagaagg ttttgggacg     4680

ctcgaaggct ttaatttgcg gccggaccaa ctatcatccg ctaattactg acattaccaa     4740

atgagatctg tgaatgggca agataaaaaa caaaaattga aatgtttgac gttatgtaaa     4800

actattaatt ccttcgcttt cggcggtcac agaatttgcg tgtagctgac tcttgttcaa     4860

tcaatatcat ttgttacttt atttgaaagt ctgtattact gcgcctattg tcatccgtac     4920

caaagaacgt caaaaagaaa caagataatt tttgtgctta caccatttat agatcactga     4980

gcccagaata tcgctggagc tcagtgtaag tggcatgaac acaactctga ctgatcgcac     5040

atattgccgt tatcataaat actagttgta cttgtcaatg cgacgaatgg catcatgcct     5100

attattacgt tcctcttttt ccgtttcatg tttccagaat gctattgaat ctaacacttc     5160

aattataaaa aagaataaat ccgcaataat tttaggctaa ttgttgtact gtcaagcgaa     5220

cctaatggtt aaaattcaga ggaaccttcg acgtagtctg atcgctactt ctatatctta     5280

tgttcccagt caatcaaaag ttgatactat aatagctgcc atttatacct gttagttatg     5340

gcgatcgttt atcacg                                                     5356


<210> 43
<211> 3492
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 43
aactcaatcg tgctaagcga caaactgaaa aggtatatca accagagatg aaatcggaaa       60

ttagcgggga tagcactctg aaacgtgttc aagtcacctt ccacgggaat ggtcgggtaa      120

ataaaaagaa aaagaaggtt cctccacgga aagatggtat caagttccgt tgattgaaaa      180

tttttctttt caagcgatga ggttagcgaa gttgttcgaa caagcccaaa tatgtttaga      240

aggcagtacg aattgatacc ctgaactgtt actacatacc acagcttttc aattcaattc      300

atcatttttt ttttattctt ttttttgatt tcggtttctt tgaaattttt ttgattcggt      360

aatctccgaa cagaaggaag aacgaaggaa ggagcacaga cttagattgg tatatatacg      420

catatgtagt gttgaagaaa catgaaattg cccagtattc ttaacccaac tgcacagaac      480

aaaaacctgc aggaaacgaa gataaatcat gtcgaaagct acatataagg aacgtgctgc      540

tactcatcct agtcctgttg ctgccaagct atttaatatc atgcacgaaa agcaaacaaa      600

cttgtgtgct tcattggatg ttcgtaccac caaggaatta ctggagttag ttgaagcatt      660

aggtcccaaa atttgtttac taaaaacaca tgtggatatc ttgactgatt tttccatgga      720

gggcacagtt aagccgctaa aggcattatc cgccaagtac aattttttac tcttcgaaga      780

cagaaaattt gctgacattg gtaatacagt caaattgcag tactctgcgg gtgtatacag      840

aatagcagaa tgggcagaca ttacgaatgc acacggtgtg gtgggcccag gtattgttag      900

cggtttgaag caggcggcag aagaagtaac aaaggaacct agaggccttt tgatgttagc      960

agaattgtca tgcaagggct ccctatctac tggagaatat actaagggta ctgttgacat     1020

tgcgaagagc gacaaagatt ttgttatcgg ctttattgct caaagagaca tgggtggaag     1080

agatgaaggt tacgattggt tgattatgac acccggtgtg ggtttagatg acaagggaga     1140

cgcattgggt caacagtata gaaccgtgga tgatgtggtc tctacaggat ctgacattat     1200

tattgttgga agaggactat ttgcaaaggg aagggatgct aaggtagagg gtgaacgtta     1260

cagaaaagca ggctgggaag catatttgag aagatgcggc cagcaaaact aaaaaactgt     1320

attataagta aatgcatgta tactaaactc acaaattaga gcttcaattt aattatatca     1380

gttattaccc tatgcggtgt gaaataccgc acagatgcgt aaggagaaaa taccgcatca     1440

ggatagcttc aaaatgtttc tactcctttt ttactcttcc agattttctc ggactccgcg     1500

catcgccgta ccacttcaaa acacccaagc acagcatact aaatttcccc tctttcttcc     1560

tctagggtgt cgttaattac ccgtactaaa ggtttggaaa agaaaaaaga gaccgcctcg     1620

tttctttttc ttcgtcgaaa aaggcaataa aaatttttat cacgtttctt tttcttgaaa     1680

attttttttt tgattttttt ctctttcgat gacctcccat tgatatttaa gttaataaac     1740

ggtcttcaat ttctcaagtt tcagtttcat ttttcttgtt ctattacaac tttttttact     1800

tcttgctcat tagaaagaaa gcatagcaat ctaatctaag tttaaaacaa tgaatgtcac     1860

ctttgaagaa agagccagtt tacacggtta cagaatcggt atcgcatcct tagacgcccc     1920

agcatccttg aacgctttgt ccttaccaat gattgatgct ttacaagaca gattgagagc     1980

ttgggcagaa gatgcagaca tagcctgtgt cttgttacgt ggtaatggtt ctaaagcatt     2040

ttgcgcaggt ggtgacgttg tccaattagc taagaaatgt ttggcctccc caggtgaagc     2100

ccctgaattg gctgaaagat ttttcgctag aagttacaga ttagatcatt atttgcacac     2160

atacccaaag cctttgatat gctgggctca tggtcacgtt ttaggtggtg gtatgggttt     2220

gttacaaggt gctggtatta gaatagtcac cccatcttca agattggcaa tgcctgaaat     2280

ctctattggt ttatttccag atgttggtgg ttcccatttc ttaagtagat tgcctggtaa     2340

attgggttta tttttcggtt taaccgcttc accattgaat gccagagatg ctttggactt     2400

aaacttggct gatagattct tgttagatac tcaacaagac gcattgatcg atggtttgat     2460

ccaattgaac tggagagaac aaccagattt gcaattgcat tccttgttaa aggctttaga     2520

acaacaagca agaagtgaat taccagctgc acaatggttg cctagaagag aaagattaga     2580

cgccttgtta gatcaagcta ctttaccatt gtcttggcaa gccttagctt cattggaaaa     2640

cgatgaagac gcattgttag ccaaagccgc taagactatg ttgggtggtt cacctttaac     2700

aggtcatttg gtctggggtc aaattagaag agctagacac ttatctttgg cacaagtatt     2760

tcaaatggaa tacggcatgt cattgaattg ttgcagacat ccagaatttg cagaaggtgt     2820

aagagccaga ttaatcgata aagaccacgc tccacattgg cactggcctg acgtaaacca     2880

agttcctgaa gccgttattg cagcccattt tgcaccatta gatgaccacc ctttagctga     2940

tttggcataa cgataccgtc gacctcgagt catgtaatta gttatgtcac gcttacattc     3000

acgccctccc cccacatccg ctctaaccga aaaggaagga gttagacaac ctgaagtcta     3060

ggtccctatt tattttttta tagttatgtt agtattaaga acgttattta tatttcaaat     3120

ttttcttttt tttctgtaca gacgcgtgta cgcatgtaac attatactga aaaccttgct     3180

tgagaaggtt ttgggacgct cgaaggcttt aatttgcggc cgtacaatca caaaattaat     3240

cataatgttc atttatctat aatcaaacaa tgagaatata tactgaagtt tggtaggtta     3300

ttcttcagag atgcagtacg atatcaccaa cggtatgcag acacctatca aaacataaac     3360

ggattcatca tgaggtaaaa cgacttcctg ttcaacgctg agatcgtgat catgagaatc     3420

tccaccaaca aatgctgtga aagacgcata tagtaaactg ccaccactca taagcagaag     3480

atttccactt at                                                         3492


<210> 44
<211> 1959
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 44
atgtcccaaa ctcataagca cgctattcca gctaatattg ctgatagatg cttgatcaac       60

ccagaacaat acgaaactaa gtacaagcaa tccatcaacg atccagatac tttttggggt      120

gaacaaggta agattttgga ttggattacc ccataccaaa aggtcaagaa tacttctttt      180

gctccaggta acgtttccat caaatggtat gaagatggta ctttgaactt ggctgctaac      240

tgtttggata gacacttgca agaaaacggt gatagaaccg ctattatttg ggaaggtgat      300

gatgcctctc aatccaaaca tatctcttac agagaattgc acagagatgt ctgtagattc      360

gctaacactt tgttggattt gggtattaag aagggtgacg ttgttgctat ctatatgcca      420

atggttcctg aagctgctgt tgctatgttg gcttgtgcta gaattggtgc tgttcattct      480

gttattttcg gtggtttttc accagaagct gttgccggta gaattatcga ttcttcatcc      540

agattggtta tcaccgctga tgaaggtgtt agagctggta gatcaattcc attgaaaaag      600

aacgttgatg acgccttgaa gaacccaaat gttacttctg ttgaacacgt catcgttttg      660

aagagaaccg attctgatat tgactggcaa gaaggtagag atttgtggtg gagagatttg      720

attgaaaagg cttctccaga acatcaacca gaagcaatga acgctgaaga tcctttgttt      780

atcttgtaca cttctggttc tactggtaag ccaaaaggtg ttttacacac tactggtggt      840

tatttggttt acgctgctac tactttcaag tacgttttcg attatcatcc aggtgacatc      900

tattggtgta ctgctgatgt tggttgggtt actggtcatt cttatttgtt gtatggtcca      960

ttagcttgtg gtgctactac cttgatgttc gaaggtgttc caaattggcc aactccagct     1020

agaatgtgtc aagttgttga caaacaccaa gtcaacatct tgtatactgc tccaactgct     1080

attagagctt tgatggctga aggtgataag gctattgaag gtactgatag atcctccttg     1140

agaatcttgg gttctgttgg tgaacctatt aaccctgaag cttgggaatg gtactggaag     1200

aaaattggta aagaaaagtg cccagttgtt gatacttggt ggcaaactga aacaggtggt     1260

tttatgatta ctccattgcc aggtgctatt gaattgaaag ctggttctgc tactagacca     1320

ttttttggtg ttcaaccagc cttggttgat aatgaaggtc atccacaaga aggtgctact     1380

gaaggtaatt tggttattac tgattcttgg ccaggtcaag ctagaacttt gtttggtgat     1440

cacgaaagat tcgaacaaac ctacttttcc accttcaaga acatgtactt ttctggtgat     1500

ggtgctagaa gagatgaaga tggttactat tggattaccg gtagagttga tgatgtcttg     1560

aatgtttctg gtcacagatt gggtacagcc gaaattgaat ctgctttggt tgctcatcca     1620

aagattgctg aagcagcagt tgttggtatt ccacatgcta ttaagggtca agcaatctac     1680

gcttacgtta ccttgaatca tggtgaagaa ccatccccag aattatacgc tgaagttaga     1740

aactgggtca gaaaagaaat tggtccattg gctactccag atgttttaca ttggacagat     1800

tctttgccaa agaccagatc aggtaagatc atgagaagaa tcttgagaaa aattgctgcc     1860

ggtgatactt ctaacttggg tgatacctct actttggctg atccaggtgt tgttgaaaag     1920

ccattagaag aaaagcaagc cattgccatg ccatcttaa                            1959


<210> 45
<211> 367
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (95)..(95)
<223> A, D, R, H, K, S, T, N, Q, or Y

<400> 45
Met Asn Leu Gln Phe Glu Glu Arg Pro Ser Leu His Gly Tyr Arg Ile 
1               5                   10                  15      


Gly Ile Ala Ser Leu Asp Ala Glu Lys Ser Leu Asn Ala Leu Thr Leu 
            20                  25                  30          


Pro Met Ile Gln Ala Leu Asp Ala Arg Leu Gln Ala Trp Ala Glu Asp 
        35                  40                  45              


Pro Thr Ile Ala Cys Val Met Leu Arg Gly Asn Gly Pro Lys Ala Phe 
    50                  55                  60                  


Cys Ala Gly Gly Asp Val Val Gln Leu Val Gln Gln Cys Arg Glu His 
65                  70                  75                  80  


Pro Gly Glu Val Pro Pro Leu Ala Arg Arg Phe Phe Ala Asp Xaa Tyr 
                85                  90                  95      


Arg Leu Asp His Arg Ile His Ser Tyr Pro Lys Pro Phe Ile Cys Trp 
            100                 105                 110         


Ala His Gly His Val Leu Gly Gly Gly Met Gly Leu Met Gln Gly Ala 
        115                 120                 125             


Gly Val Arg Ile Val Thr Pro Ser Ser Arg Leu Gly Met Pro Glu Ile 
    130                 135                 140                 


Asn Ile Gly Leu Tyr Pro Asp Val Gly Gly Ser Trp Phe Leu Ala Arg 
145                 150                 155                 160 


Leu Pro Gly Arg Leu Gly Leu Phe Leu Gly Leu Thr Ala Ala Ser Ile 
                165                 170                 175     


Asn Ala Arg Asp Ala Leu Asp Leu Asn Leu Ala Asp Arg Phe Leu Arg 
            180                 185                 190         


Asp Asp Gln Gln Asp Ala Leu Leu Glu Gly Leu Val Gln Leu Asn Trp 
        195                 200                 205             


Arg Glu Gln Pro Ala Ala Gln Leu His Ser Leu Leu Arg Ala Leu Glu 
    210                 215                 220                 


Asn Glu Ala Arg Gly Glu Leu Pro Ala Ala Gln Trp Leu Pro Arg Arg 
225                 230                 235                 240 


Glu Arg Ile Asp Glu Leu Leu Asp Val Ala Asp Leu Pro Ala Ala Val 
                245                 250                 255     


Gln Ala Ile Ser Ala Leu Gln Gln Asp Asp Asp Ala Leu Leu Ala Arg 
            260                 265                 270         


Ala Ala Lys Thr Leu Ala His Gly Cys Pro Leu Thr Ala His Leu Val 
        275                 280                 285             


Trp Gln Gln Ile Arg Arg Ala Arg His Leu Ser Leu Ala Glu Val Phe 
    290                 295                 300                 


Arg Met Glu Tyr Ala Met Ser Leu Asn Cys Cys Arg His Pro Asp Phe 
305                 310                 315                 320 


Pro Glu Gly Val Arg Ala Arg Leu Ile Asp Lys Asp Gln Thr Pro His 
                325                 330                 335     


Trp His Trp Pro Asp Val Ala Ala Ile Pro Glu Ala Val Ile Glu Ala 
            340                 345                 350         


His Phe Ala Pro Ala Trp Glu Gly Glu His Pro Leu Ala Asp Leu 
        355                 360                 365         


<210> 46
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (91)..(91)
<223> A, D, R, H, K, S, T, N, Q, or Y

<400> 46
Met Thr Glu His Val Leu Phe Ser Val Ser Glu Asn Gly Val Ala Ser 
1               5                   10                  15      


Ile Thr Leu Asn Arg Pro Lys Ala Leu Asn Ser Leu Ser Tyr Asp Met 
            20                  25                  30          


Leu Gln Pro Ile Gly Gln Lys Leu Lys Glu Trp Glu Asn Asp Glu Arg 
        35                  40                  45              


Ile Ala Leu Ile Val Leu Lys Gly Ala Gly Thr Lys Gly Phe Cys Ala 
    50                  55                  60                  


Gly Gly Asp Ile Lys Thr Leu Tyr Glu Ala Arg Ser Asn Glu Ala Ala 
65                  70                  75                  80  


Leu Gln His Ala Glu Arg Phe Phe Glu Glu Xaa Tyr Glu Ile Asp Thr 
                85                  90                  95      


Tyr Ile Tyr Gln Tyr Lys Lys Pro Ile Ile Ala Cys Leu Asp Gly Ile 
            100                 105                 110         


Val Met Gly Gly Gly Val Gly Leu Thr Asn Gly Ala Lys Tyr Arg Ile 
        115                 120                 125             


Val Thr Glu Arg Thr Lys Trp Ala Met Pro Glu Met Asn Ile Gly Phe 
    130                 135                 140                 


Phe Pro Asp Val Gly Ala Ala Tyr Phe Leu Asn Lys Ala Pro Gly Tyr 
145                 150                 155                 160 


Ala Gly Arg Tyr Val Ala Leu Thr Ala Ser Ile Leu Lys Ala Ser Asp 
                165                 170                 175     


Val Leu Phe Ile Asn Ala Ala Asp Tyr Phe Ile Ala Ser Asp Ser Leu 
            180                 185                 190         


Pro Asn Phe Leu Thr Glu Leu Glu Ser Val Asn Trp Ser Lys Glu Asp 
        195                 200                 205             


Asp Val His Thr His Leu Lys Glu Val Ile Arg Thr Phe Ala Thr Ala 
    210                 215                 220                 


Pro Thr Leu Glu Ser Glu Leu Ala Pro Ser Leu Glu Glu Ile Asn Ser 
225                 230                 235                 240 


His Phe Ala Phe Asp Thr Ile Glu Glu Ile Ile His Ser Leu Glu Lys 
                245                 250                 255     


Asp Gln Ser Ser Phe Ser Leu Lys Ala Lys Glu Thr Leu Leu Ser Lys 
            260                 265                 270         


Ser Pro Ile Ser Leu Lys Val Thr Leu Lys Gln Phe Ile Asp Gly Gln 
        275                 280                 285             


Asn Lys Ser Val Glu Glu Cys Phe Ala Thr Asp Leu Val Leu Ala Lys 
    290                 295                 300                 


Asn Phe Met Arg His Glu Asp Phe Phe Glu Gly Val Arg Ser Val Val 
305                 310                 315                 320 


Val Asp Lys Asp Gln Asn Pro Asn Tyr Lys Tyr Lys Gln Leu Ser Asp 
                325                 330                 335     


Val Ser Glu Glu Asp Val Asn Arg Phe Phe Asn Leu Leu Asn Ala 
            340                 345                 350     


<210> 47
<211> 360
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (101)..(101)
<223> A, D, R, H, K, S, T, N, Q, or Y

<400> 47
Met Arg Arg Tyr Ile Arg Gly Gly Phe Lys Met Thr Glu Asn Val Leu 
1               5                   10                  15      


Phe Ser Ile His Glu Asn Gly Val Ala Ser Ile Thr Leu Asn Arg Pro 
            20                  25                  30          


Lys Ala Leu Asn Ser Leu Ser Tyr Asp Met Leu His Pro Ile Gly Gln 
        35                  40                  45              


Lys Leu Lys Glu Trp Glu Lys Asp Asp Arg Ile Ala Val Val Ile Leu 
    50                  55                  60                  


Lys Gly Ala Gly Thr Lys Gly Phe Cys Ala Gly Gly Asp Ile Lys Thr 
65                  70                  75                  80  


Leu Tyr Glu Ala Arg Ser Asn Glu Val Ala Leu Gln His Ala Glu His 
                85                  90                  95      


Phe Phe Glu Glu Xaa Tyr Glu Ile Asp Thr Tyr Ile Tyr His Tyr Pro 
            100                 105                 110         


Lys Pro Ile Ile Ala Cys Leu Asp Gly Ile Val Met Gly Gly Gly Val 
        115                 120                 125             


Gly Leu Thr Asn Gly Ala Lys Tyr Arg Ile Val Thr Asp Arg Thr Lys 
    130                 135                 140                 


Trp Ala Met Pro Glu Met Asn Ile Gly Phe Phe Pro Asp Val Gly Ala 
145                 150                 155                 160 


Ala Tyr Phe Leu Asn Lys Ala Pro Gly Gln Thr Gly Arg Tyr Val Ala 
                165                 170                 175     


Leu Thr Ala Ser Val Leu Lys Ala Ala Asp Val Leu Tyr Ile Lys Ala 
            180                 185                 190         


Ala Asp His Tyr Met Pro Ser Glu Thr Leu Pro Thr Phe Leu Asp Ala 
        195                 200                 205             


Ile Glu Lys Val Asn Trp His Asp Gln Asn Ile His Ile Thr Leu Lys 
    210                 215                 220                 


Glu Leu Ile Asn Lys Tyr Glu Thr Ala Pro Ser Val Glu Ser Glu Leu 
225                 230                 235                 240 


Val Ser Leu Leu Glu Glu Ile Asp Gln His Phe Ser Phe His Thr Val 
                245                 250                 255     


Glu Asp Ile Ile His Ser Leu Asp Asn Ala Asp Gly Ser Phe Ala Ser 
            260                 265                 270         


Lys Thr Lys Glu Thr Leu Leu Ser Lys Ser Pro Phe Ser Leu Lys Val 
        275                 280                 285             


Thr Leu Lys Gln Leu Ile Asp Gly Lys Glu Lys Ser Ile Glu Glu Cys 
    290                 295                 300                 


Phe Ala Thr Asp Leu Val Leu Ala Lys Asn Phe Met Arg His Glu Asp 
305                 310                 315                 320 


Phe Phe Glu Gly Val Arg Ser Val Val Val Asp Lys Asp Gln Asn Pro 
                325                 330                 335     


Lys Tyr Lys Tyr Lys Gln Leu Ser Asp Val Ser Asp Glu Asp Val Asn 
            340                 345                 350         


Arg Phe Phe Asn Leu Leu Asn Ala 
        355                 360 


<210> 48
<211> 370
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (95)..(95)
<223> A, D, R, H, K, S, T, N, Q, or Y

<400> 48
Met Asn Leu His Phe Glu Glu Leu Thr Gly Ser Asp Gly Ala Arg Ile 
1               5                   10                  15      


Gly Ile Ala Ser Leu Asp Ala Glu Lys Ser Leu Asn Ala Leu Ser Leu 
            20                  25                  30          


Pro Met Ile Leu Ala Leu Gly Asp Arg Leu Asp Ala Trp Ala Lys Asp 
        35                  40                  45              


Pro Asn Ile Val Cys Val Leu Leu Arg Gly Asn Gly Pro Lys Ala Phe 
    50                  55                  60                  


Cys Ala Gly Gly Glu Val Arg Ser Leu Ala Leu Ala Cys Arg Glu Gln 
65                  70                  75                  80  


Pro Gly Glu Val Pro Ala Leu Ala Ala Gln Phe Phe Ala Ala Xaa Tyr 
                85                  90                  95      


Arg Leu Asp Tyr Arg Leu His Thr Phe Pro Lys Pro Leu Ile Cys Trp 
            100                 105                 110         


Gly His Gly Tyr Val Leu Gly Gly Gly Met Gly Leu Leu Gln Ser Ala 
        115                 120                 125             


Ala Val Arg Ile Val Thr Pro Ser Ser Arg Leu Ala Met Pro Glu Ile 
    130                 135                 140                 


Ser Ile Gly Leu Tyr Pro Asp Val Gly Ala Ser Trp Phe Leu Ser Arg 
145                 150                 155                 160 


Leu Pro Gly Lys Leu Gly Leu Phe Leu Gly Leu Thr Gly Ala His Val 
                165                 170                 175     


Asn Gly Arg Asp Ala Leu Asp Leu Gly Leu Ala Asp Arg Phe Leu Arg 
            180                 185                 190         


Asp Asp Gln Gln Asp Glu Leu Ile Glu Gly Leu Leu Gln Leu Asn Trp 
        195                 200                 205             


Gln Glu Gln Thr Ala Met Gln Leu Asn Ser Leu Phe Lys Ala Leu Ala 
    210                 215                 220                 


Gln Glu Ala Val Asp Gln Leu Pro Glu Ala Gln Trp Leu Pro Arg Arg 
225                 230                 235                 240 


Ala Gln Ile Asp Glu Trp Leu Asp Val Gly Asp Val Arg Ser Ala Trp 
                245                 250                 255     


Arg Ala Leu Ser Gln Leu Arg Asp His Ala Asp Pro Leu Phe Ser Arg 
            260                 265                 270         


Ala Gly Lys Thr Leu Ser Glu Gly Cys Pro Leu Thr Ala His Leu Val 
        275                 280                 285             


Trp Glu Gln Ile Gln Arg Ala Arg His Leu Ser Leu Ala Gln Val Phe 
    290                 295                 300                 


Gln Met Glu Tyr Thr Leu Ser Leu Asn Cys Cys Arg His Pro Glu Phe 
305                 310                 315                 320 


Ser Glu Gly Val Arg Ala Arg Leu Ile Asp Lys Asp Gln Thr Pro Arg 
                325                 330                 335     


Trp His Trp Pro Asp Val His Thr Leu Pro Asp Ala Val Val Gln Ala 
            340                 345                 350         


His Phe Asn Lys Ala Trp Glu Gly Arg His Pro Leu Ala Asp Leu Ser 
        355                 360                 365             


Asp Tyr 
    370 


<210> 49
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (91)..(91)
<223> A, D, R, H, K, S, T, N, Q, or Y

<400> 49
Met Thr Glu His Val Leu Phe Ser Val Ser Glu Asn Gly Val Ala Ser 
1               5                   10                  15      


Ile Thr Leu Asn Arg Pro Lys Ala Leu Asn Ser Leu Ser Tyr Asp Met 
            20                  25                  30          


Leu Gln Pro Ile Gly Gln Lys Leu Lys Glu Trp Glu His Asp Glu Arg 
        35                  40                  45              


Ile Ala Leu Ile Val Leu Lys Gly Ala Gly Thr Lys Gly Phe Cys Ala 
    50                  55                  60                  


Gly Gly Asp Ile Lys Thr Leu Tyr Glu Ala Arg Ser Asn Glu Ala Ala 
65                  70                  75                  80  


Leu Gln His Ala Glu Arg Phe Phe Glu Glu Xaa Tyr Glu Ile Asp Thr 
                85                  90                  95      


Tyr Ile Tyr Gln Tyr Lys Lys Pro Ile Ile Ala Cys Leu Asp Gly Ile 
            100                 105                 110         


Val Met Gly Gly Gly Val Gly Leu Thr Asn Gly Ala Lys Tyr Arg Ile 
        115                 120                 125             


Val Thr Glu Arg Thr Lys Trp Ala Met Pro Glu Met Asn Ile Gly Phe 
    130                 135                 140                 


Phe Pro Asp Val Gly Ala Ala Tyr Phe Leu Asn Lys Ala Pro Gly Tyr 
145                 150                 155                 160 


Ala Gly Arg Tyr Val Ala Leu Thr Ala Ser Ile Leu Lys Ala Ala Asp 
                165                 170                 175     


Val Leu Phe Ile Asn Ala Ala Asp Tyr Phe Ile Ala Ser Asp Ser Leu 
            180                 185                 190         


Pro Asn Phe Leu Thr Glu Leu Glu Ser Val Asn Trp Pro Lys Lys Asp 
        195                 200                 205             


Asp Val His Thr His Leu Lys Glu Val Ile Arg Thr Phe Ala Thr Ala 
    210                 215                 220                 


Pro Thr Leu Glu Ser Glu Leu Ala Pro Ser Leu Glu Glu Ile Asn Ser 
225                 230                 235                 240 


His Phe Ala Phe Asp Thr Ile Glu Glu Ile Ile His Ser Leu Glu Lys 
                245                 250                 255     


Asp Gln Ser Ser Phe Ala Leu Lys Ala Lys Glu Thr Leu Leu Ser Lys 
            260                 265                 270         


Ser Pro Ile Ser Leu Lys Val Thr Leu Lys Gln Phe Ile Asp Gly Gln 
        275                 280                 285             


Asn Lys Ser Val Glu Glu Cys Phe Ala Thr Asp Leu Val Leu Ala Lys 
    290                 295                 300                 


Asn Phe Met Arg His Glu Asp Phe Phe Glu Gly Val Arg Ser Val Val 
305                 310                 315                 320 


Val Asp Lys Asp Gln Asn Pro Asp Tyr Lys Tyr Lys Gln Leu Ser Asp 
                325                 330                 335     


Val Ser Glu Glu Asp Val Asn Arg Phe Phe Asn Leu Leu Asn Ala 
            340                 345                 350     


<210> 50
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (95)..(95)
<223> A, D, R, H, K, S, T, N, Q, or Y

<400> 50
Met Asn Val Thr Phe Glu Glu Arg Ala Ser Leu His Gly Tyr Arg Ile 
1               5                   10                  15      


Gly Ile Ala Ser Leu Asp Ala Pro Ala Ser Leu Asn Ala Leu Ser Leu 
            20                  25                  30          


Pro Met Ile Asp Ala Leu Gln Asp Arg Leu Arg Ala Trp Ala Glu Asp 
        35                  40                  45              


Ala Asp Ile Ala Cys Val Leu Leu Arg Gly Asn Gly Ser Lys Ala Phe 
    50                  55                  60                  


Cys Ala Gly Gly Asp Val Val Gln Leu Ala Lys Lys Cys Leu Ala Ser 
65                  70                  75                  80  


Pro Gly Glu Ala Pro Glu Leu Ala Glu Arg Phe Phe Ala Arg Xaa Tyr 
                85                  90                  95      


Arg Leu Asp His Tyr Leu His Thr Tyr Pro Lys Pro Leu Ile Cys Trp 
            100                 105                 110         


Ala His Gly His Val Leu Gly Gly Gly Met Gly Leu Leu Gln Gly Ala 
        115                 120                 125             


Gly Ile Arg Ile Val Thr Pro Ser Ser Arg Leu Ala Met Pro Glu Ile 
    130                 135                 140                 


Ser Ile Gly Leu Phe Pro Asp Val Gly Gly Ser His Phe Leu Ser Arg 
145                 150                 155                 160 


Leu Pro Gly Lys Leu Gly Leu Phe Phe Gly Leu Thr Ala Ser Pro Leu 
                165                 170                 175     


Asn Ala Arg Asp Ala Leu Asp Leu Asn Leu Ala Asp Arg Phe Leu Leu 
            180                 185                 190         


Asp Thr Gln Gln Asp Ala Leu Ile Asp Gly Leu Ile Gln Leu Asn Trp 
        195                 200                 205             


Arg Glu Gln Pro Asp Leu Gln Leu His Ser Leu Leu Lys Ala Leu Glu 
    210                 215                 220                 


Gln Gln Ala Arg Ser Glu Leu Pro Ala Ala Gln Trp Leu Pro Arg Arg 
225                 230                 235                 240 


Glu Arg Leu Asp Ala Leu Leu Asp Gln Ala Thr Leu Pro Leu Ser Trp 
                245                 250                 255     


Gln Ala Leu Ala Ser Leu Glu Asn Asp Glu Asp Ala Leu Leu Ala Lys 
            260                 265                 270         


Ala Ala Lys Thr Met Leu Gly Gly Ser Pro Leu Thr Gly His Leu Val 
        275                 280                 285             


Trp Gly Gln Ile Arg Arg Ala Arg His Leu Ser Leu Ala Gln Val Phe 
    290                 295                 300                 


Gln Met Glu Tyr Gly Met Ser Leu Asn Cys Cys Arg His Pro Glu Phe 
305                 310                 315                 320 


Ala Glu Gly Val Arg Ala Arg Leu Ile Asp Lys Asp His Ala Pro His 
                325                 330                 335     


Trp His Trp Pro Asp Val Asn Gln Val Pro Glu Gln Val Ile Ala Ala 
            340                 345                 350         


His Phe Ala Pro Leu Asp Asp His Pro Leu Ala Asp Leu Ala 
        355                 360                 365     


<210> 51
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (91)..(91)
<223> A, D, R, H, K, S, T, N, Q, or Y

<400> 51
Met Thr Glu His Val Leu Phe Ser Val Ser Glu Asn Gly Val Ala Ser 
1               5                   10                  15      


Ile Thr Leu Asn Arg Pro Lys Ala Leu Asn Ser Leu Ser Tyr Glu Met 
            20                  25                  30          


Leu Gln Pro Ile Gly Lys Lys Leu Lys Glu Trp Glu Asn Asp Glu Gln 
        35                  40                  45              


Ile Ala Leu Ile Val Leu Lys Gly Ala Gly Thr Lys Gly Phe Cys Ala 
    50                  55                  60                  


Gly Gly Asp Ile Lys Thr Leu Tyr Glu Ala Arg Ser Asn Glu Ile Ala 
65                  70                  75                  80  


Leu Gln His Ala Glu Arg Phe Phe Glu Glu Xaa Tyr Glu Ile Asp Thr 
                85                  90                  95      


Tyr Ile Tyr Gln Tyr Lys Lys Pro Ile Ile Ala Cys Leu Asp Gly Ile 
            100                 105                 110         


Val Met Gly Gly Gly Val Gly Leu Thr Asn Gly Ala Lys Tyr Arg Ile 
        115                 120                 125             


Val Thr Glu Arg Thr Lys Trp Ala Met Pro Glu Met Asn Ile Gly Phe 
    130                 135                 140                 


Phe Pro Asp Val Gly Ala Ala Tyr Phe Leu Asn Lys Ala Pro Gly Phe 
145                 150                 155                 160 


Ala Gly Arg Tyr Val Ala Leu Thr Ala Ser Ile Leu Lys Ala Ser Asp 
                165                 170                 175     


Val Leu Phe Ile Asn Ala Ala Asp Tyr Phe Met Thr Ser Asp Ser Leu 
            180                 185                 190         


Pro Lys Phe Leu Thr Glu Leu Glu Ser Val Asn Trp His Lys Gly Asp 
        195                 200                 205             


Asp Val His Ile His Leu Lys Glu Val Ile Arg Thr Phe Ala Thr Thr 
    210                 215                 220                 


Ser Asn Leu Glu Ser Glu Leu Ala Pro Leu Leu Glu Glu Ile Asn Ala 
225                 230                 235                 240 


His Phe Ala Phe Asp Thr Ile Glu Glu Ile Ile His Ser Leu Glu Lys 
                245                 250                 255     


Asp Gln Ser Ser Phe Ala Leu Lys Thr Lys Lys Thr Leu Leu Ser Lys 
            260                 265                 270         


Ser Pro Ile Ser Leu Lys Val Thr Leu Lys Gln Phe Ile Asp Gly His 
        275                 280                 285             


Asp Lys Ser Val Glu Glu Cys Phe Ala Thr Asp Leu Val Leu Ala Lys 
    290                 295                 300                 


Asn Phe Met Arg His Glu Asp Phe Phe Glu Gly Val Arg Ser Val Val 
305                 310                 315                 320 


Val Asp Lys Asp Gln Asn Pro Asn Tyr Lys Tyr Lys Gln Leu Ser Asp 
                325                 330                 335     


Val Ser Asp Glu Asp Val Asn Arg Phe Phe Asn Leu Leu Asn Ala 
            340                 345                 350     


<210> 52
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (91)..(91)
<223> A, D, R, H, K, S, T, N, Q, or Y

<400> 52
Met Thr Glu Gln Val Leu Phe Ser Val Ser Glu Asn Gly Val Ala Thr 
1               5                   10                  15      


Ile Thr Leu Asn Arg Pro Lys Ala Leu Asn Ser Leu Ser Tyr Asp Met 
            20                  25                  30          


Leu Gln Pro Ile Gly Gln Lys Leu Lys Glu Trp Glu His Asp Glu Arg 
        35                  40                  45              


Ile Ala Leu Ile Val Leu Lys Gly Ala Gly Thr Lys Gly Phe Cys Ala 
    50                  55                  60                  


Gly Gly Asp Ile Lys Thr Leu Tyr Glu Ala Arg Ser Asn Glu Val Ala 
65                  70                  75                  80  


Leu Gln His Ala Glu Arg Phe Phe Glu Glu Xaa Tyr Glu Ile Asp Thr 
                85                  90                  95      


Tyr Ile Tyr Gln Tyr Thr Lys Pro Ile Ile Ala Cys Leu Asp Gly Ile 
            100                 105                 110         


Val Met Gly Gly Gly Val Gly Leu Thr Asn Gly Ala Lys Tyr Arg Ile 
        115                 120                 125             


Val Thr Glu Arg Thr Lys Trp Ala Met Pro Glu Met Asn Ile Gly Phe 
    130                 135                 140                 


Phe Pro Asp Val Gly Ala Ala Tyr Phe Leu Asn Lys Ala Pro Gly Tyr 
145                 150                 155                 160 


Thr Gly Arg Phe Val Ala Leu Thr Ala Ser Ile Leu Lys Ala Ser Asp 
                165                 170                 175     


Val Leu Phe Ile Asn Ala Ala Asp Tyr Phe Met Thr Ser Asp Ser Leu 
            180                 185                 190         


Pro Glu Phe Leu Thr Glu Leu Glu Ser Val Asn Trp His Lys Glu Asp 
        195                 200                 205             


Asp Val His Thr Asn Leu Lys Glu Val Ile Arg Thr Phe Ala Thr Ala 
    210                 215                 220                 


Pro Asn Leu Glu Ser Glu Leu Ala Pro Ser Leu Glu Val Ile Asn Ser 
225                 230                 235                 240 


His Phe Ala Phe Asp Thr Ile Glu Glu Ile Ile His Ser Leu Glu Lys 
                245                 250                 255     


Asp Glu Ser Ser Phe Ala Leu Lys Thr Lys Glu Ile Leu Leu Ser Lys 
            260                 265                 270         


Ser Pro Ile Ser Leu Lys Val Thr Leu Lys Gln Phe Ile Asp Gly Gln 
        275                 280                 285             


Asp Lys Ser Val Glu Glu Cys Phe Ala Thr Asp Leu Ile Leu Ala Lys 
    290                 295                 300                 


Asn Phe Met Arg His Glu Asp Phe Phe Glu Gly Val Arg Ser Val Val 
305                 310                 315                 320 


Val Asp Lys Asp Gln Asn Pro Asn Tyr Lys Tyr Lys Gln Leu Ser Asp 
                325                 330                 335     


Val Ser Glu Glu Asp Val Asn Arg Phe Phe Asn Leu Leu Asn Ala 
            340                 345                 350     


<210> 53
<211> 309
<212> PRT
<213> Escherichia coli

<400> 53
Met Thr Gln Phe Ala Phe Val Phe Pro Gly Gln Gly Ser Gln Thr Val 
1               5                   10                  15      


Gly Met Leu Ala Asp Met Ala Ala Ser Tyr Pro Ile Val Glu Glu Thr 
            20                  25                  30          


Phe Ala Glu Ala Ser Ala Ala Leu Gly Tyr Asp Leu Trp Ala Leu Thr 
        35                  40                  45              


Gln Gln Gly Pro Ala Glu Glu Leu Asn Lys Thr Trp Gln Thr Gln Pro 
    50                  55                  60                  


Ala Leu Leu Thr Ala Ser Val Ala Leu Tyr Arg Val Trp Gln Gln Gln 
65                  70                  75                  80  


Gly Gly Lys Ala Pro Ala Met Met Ala Gly His Ser Leu Gly Glu Tyr 
                85                  90                  95      


Ser Ala Leu Val Cys Ala Gly Val Ile Asp Phe Ala Asp Ala Val Arg 
            100                 105                 110         


Leu Val Glu Met Arg Gly Lys Phe Met Gln Glu Ala Val Pro Glu Gly 
        115                 120                 125             


Thr Gly Ala Met Ala Ala Ile Ile Gly Leu Asp Asp Ala Ser Ile Ala 
    130                 135                 140                 


Lys Ala Cys Glu Glu Ala Ala Glu Gly Gln Val Val Ser Pro Val Asn 
145                 150                 155                 160 


Phe Asn Ser Pro Gly Gln Val Val Ile Ala Gly His Lys Glu Ala Val 
                165                 170                 175     


Glu Arg Ala Gly Ala Ala Cys Lys Ala Ala Gly Ala Lys Arg Ala Leu 
            180                 185                 190         


Pro Leu Pro Val Ser Val Pro Ser His Cys Ala Leu Met Lys Pro Ala 
        195                 200                 205             


Ala Asp Lys Leu Ala Val Glu Leu Ala Lys Ile Thr Phe Asn Ala Pro 
    210                 215                 220                 


Thr Val Pro Val Val Asn Asn Val Asp Val Lys Cys Glu Thr Asn Gly 
225                 230                 235                 240 


Asp Ala Ile Arg Asp Ala Leu Val Arg Gln Leu Tyr Asn Pro Val Gln 
                245                 250                 255     


Trp Thr Lys Ser Val Glu Tyr Met Ala Ala Gln Gly Val Glu His Leu 
            260                 265                 270         


Tyr Glu Val Gly Pro Gly Lys Val Leu Thr Gly Leu Thr Lys Arg Ile 
        275                 280                 285             


Val Asp Thr Leu Thr Ala Ser Ala Leu Asn Glu Pro Ser Ala Met Ala 
    290                 295                 300                 


Ala Ala Leu Glu Leu 
305                 


<210> 54
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10          


<210> 55
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Gly Gly Ser Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210> 56
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Glu Ala Ala Ala Lys Gly Gly Ser Gly Gly Ser Glu Ala Ala Ala Lys 
1               5                   10                  15      


<210> 57
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Met Asn Val Thr Phe Glu Glu Arg Ala Ser Leu His Gly Tyr Arg Ile 
1               5                   10                  15      


Gly Ile Ala Ser Leu Asp Ala Pro Ala Ser Leu Asn Ala Leu Ser Leu 
            20                  25                  30          


Pro Met Ile Asp Ala Leu Gln Asp Arg Leu Arg Ala Trp Ala Glu Asp 
        35                  40                  45              


Ala Asp Ile Ala Cys Val Leu Leu Arg Gly Asn Gly Ser Lys Ala Phe 
    50                  55                  60                  


Cys Ala Gly Gly Asp Val Val Gln Leu Ala Lys Lys Cys Leu Ala Ser 
65                  70                  75                  80  


Pro Gly Glu Ala Pro Glu Leu Ala Glu Arg Phe Phe Ala Arg Glu Tyr 
                85                  90                  95      


Arg Leu Asp His Tyr Leu His Thr Tyr Pro Lys Pro Leu Ile Cys Trp 
            100                 105                 110         


Ala His Gly His Val Leu Gly Gly Gly Met Gly Leu Leu Gln Gly Ala 
        115                 120                 125             


Gly Ile Arg Ile Val Thr Pro Ser Ser Arg Leu Ala Met Pro Glu Ile 
    130                 135                 140                 


Ser Ile Gly Leu Phe Pro Asp Val Gly Gly Ser His Phe Leu Ser Arg 
145                 150                 155                 160 


Leu Pro Gly Lys Leu Gly Leu Phe Phe Gly Leu Thr Ala Ser Pro Leu 
                165                 170                 175     


Asn Ala Arg Asp Ala Leu Asp Leu Asn Leu Ala Asp Arg Phe Leu Leu 
            180                 185                 190         


Asp Thr Gln Gln Asp Ala Leu Ile Asp Gly Leu Ile Gln Leu Asn Trp 
        195                 200                 205             


Arg Glu Gln Pro Asp Leu Gln Leu His Ser Leu Leu Lys Ala Leu Glu 
    210                 215                 220                 


Gln Gln Ala Arg Ser Glu Leu Pro Ala Ala Gln Trp Leu Pro Arg Arg 
225                 230                 235                 240 


Glu Arg Leu Asp Ala Leu Leu Asp Gln Ala Thr Leu Pro Leu Ser Trp 
                245                 250                 255     


Gln Ala Leu Ala Ser Leu Glu Asn Asp Glu Asp Ala Leu Leu Ala Lys 
            260                 265                 270         


Ala Ala Lys Thr Met Leu Gly Gly Ser Pro Leu Thr Gly His Leu Val 
        275                 280                 285             


Trp Gly Gln Ile Arg Arg Ala Arg His Leu Ser Leu Ala Gln Val Phe 
    290                 295                 300                 


Gln Met Glu Tyr Gly Met Ser Leu Asn Cys Cys Arg His Pro Glu Phe 
305                 310                 315                 320 


Ala Glu Gly Val Arg Ala Arg Leu Ile Asp Lys Asp His Ala Pro His 
                325                 330                 335     


Trp His Trp Pro Asp Val Asn Gln Val Pro Glu Gln Val Ile Ala Ala 
            340                 345                 350         


His Phe Ala Pro Leu Asp Asp His Pro Leu Ala Asp Leu Ala 
        355                 360                 365     


<210> 58
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (151)..(151)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (152)..(152)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (159)..(159)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (176)..(176)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (198)..(198)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (224)..(224)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (225)..(225)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (250)..(250)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (252)..(252)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (270)..(270)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (279)..(279)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (286)..(286)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (311)..(311)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (333)..(333)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (334)..(334)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (336)..(336)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Any amino acid such as any naturally occurring amino acid

<400> 58
Met Xaa Val Xaa Phe Glu Glu Arg Ala Ser Xaa His Gly Xaa Arg Ile 
1               5                   10                  15      


Gly Ile Ala Ser Leu Asp Ala Pro Ala Ser Leu Asn Ala Leu Ser Leu 
            20                  25                  30          


Pro Met Ile Xaa Ala Leu Xaa Asp Xaa Leu Xaa Xaa Trp Ala Xaa Asp 
        35                  40                  45              


Ala Xaa Ile Ala Cys Val Leu Leu Arg Gly Asn Gly Ser Lys Ala Phe 
    50                  55                  60                  


Cys Ala Gly Gly Asp Val Val Xaa Leu Ala Xaa Lys Cys Leu Xaa Xaa 
65                  70                  75                  80  


Pro Gly Xaa Ala Pro Xaa Leu Ala Xaa Xaa Phe Phe Ala Xaa Xaa Tyr 
                85                  90                  95      


Arg Leu Xaa Xaa Xaa Leu His Thr Tyr Pro Lys Pro Leu Ile Cys Trp 
            100                 105                 110         


Ala His Gly His Val Leu Gly Gly Gly Met Gly Leu Leu Gln Gly Ala 
        115                 120                 125             


Xaa Xaa Arg Ile Val Thr Pro Ser Ser Arg Leu Ala Met Pro Glu Ile 
    130                 135                 140                 


Xaa Ile Gly Leu Phe Pro Xaa Xaa Gly Gly Ser His Phe Leu Xaa Arg 
145                 150                 155                 160 


Leu Pro Gly Lys Leu Gly Leu Phe Phe Gly Leu Thr Ala Ser Xaa Xaa 
                165                 170                 175     


Asn Ala Arg Asp Ala Leu Asp Leu Asn Leu Ala Asp Arg Phe Leu Leu 
            180                 185                 190         


Asp Xaa Gln Gln Xaa Xaa Leu Ile Asp Gly Leu Ile Gln Leu Asn Trp 
        195                 200                 205             


Arg Glu Xaa Pro Xaa Xaa Gln Leu His Ser Leu Leu Lys Ala Leu Xaa 
    210                 215                 220                 


Xaa Gln Ala Xaa Xaa Glu Leu Pro Ala Ala Gln Trp Leu Pro Arg Arg 
225                 230                 235                 240 


Xaa Xaa Leu Asp Xaa Leu Leu Asp Gln Xaa Thr Xaa Xaa Xaa Ser Trp 
                245                 250                 255     


Xaa Ala Leu Xaa Xaa Leu Xaa Xaa Asp Xaa Asp Xaa Leu Xaa Ala Xaa 
            260                 265                 270         


Ala Ala Lys Thr Met Xaa Xaa Gly Ser Pro Leu Thr Gly Xaa Leu Val 
        275                 280                 285             


Trp Gly Gln Ile Xaa Arg Ala Arg His Leu Ser Leu Ala Gln Val Xaa 
    290                 295                 300                 


Gln Met Glu Tyr Xaa Met Xaa Leu Asn Cys Cys Arg His Pro Glu Phe 
305                 310                 315                 320 


Ala Glu Gly Val Arg Ala Arg Leu Ile Asp Lys Asp Xaa Xaa Pro Xaa 
                325                 330                 335     


Trp His Trp Pro Asp Val Xaa Xaa Val Pro Xaa Gln Val Ile Ala Ala 
            340                 345                 350         


His Phe Xaa Pro Leu Asp Asp His Xaa Leu Ala Asp Leu Ala 
        355                 360                 365     


<210> 59
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (79)..(79)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (80)..(80)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (83)..(83)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (94)..(94)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (99)..(99)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (100)..(100)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (130)..(130)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (145)..(145)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (254)..(254)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (293)..(293)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (304)..(304)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (343)..(343)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (347)..(347)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (355)..(355)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (361)..(361)
<223> Any amino acid such as any naturally occurring amino acid

<400> 59
Met Xaa Val Xaa Phe Glu Glu Arg Ala Ser Xaa His Gly Xaa Arg Ile 
1               5                   10                  15      


Gly Ile Ala Ser Leu Asp Ala Pro Ala Ser Leu Asn Ala Leu Ser Leu 
            20                  25                  30          


Pro Met Ile Xaa Ala Leu Xaa Asp Xaa Leu Xaa Xaa Trp Ala Xaa Asp 
        35                  40                  45              


Ala Xaa Ile Ala Cys Val Leu Leu Arg Gly Asn Gly Ser Lys Ala Phe 
    50                  55                  60                  


Cys Ala Gly Gly Asp Val Val Xaa Leu Ala Xaa Lys Cys Leu Xaa Xaa 
65                  70                  75                  80  


Pro Gly Xaa Ala Pro Xaa Leu Ala Xaa Xaa Phe Phe Ala Xaa Xaa Tyr 
                85                  90                  95      


Arg Leu Xaa Xaa Xaa Leu His Thr Tyr Pro Lys Pro Leu Ile Cys Trp 
            100                 105                 110         


Ala His Gly His Val Leu Gly Gly Gly Met Gly Leu Leu Gln Gly Ala 
        115                 120                 125             


Xaa Xaa Arg Ile Val Thr Pro Ser Ser Arg Leu Ala Met Pro Glu Ile 
    130                 135                 140                 


Xaa Ile Gly Leu Phe Pro Asp Val Gly Gly Ser His Phe Leu Ser Arg 
145                 150                 155                 160 


Leu Pro Gly Lys Leu Gly Leu Phe Phe Gly Leu Thr Ala Ser Xaa Leu 
                165                 170                 175     


Asn Ala Arg Asp Ala Leu Asp Leu Asn Leu Ala Asp Arg Phe Leu Leu 
            180                 185                 190         


Asp Xaa Gln Gln Xaa Ala Leu Ile Asp Gly Leu Ile Gln Leu Asn Trp 
        195                 200                 205             


Arg Glu Gln Pro Xaa Xaa Gln Leu His Ser Leu Leu Lys Ala Leu Glu 
    210                 215                 220                 


Gln Gln Ala Xaa Xaa Glu Leu Pro Ala Ala Gln Trp Leu Pro Arg Arg 
225                 230                 235                 240 


Xaa Xaa Leu Asp Xaa Leu Leu Asp Gln Ala Thr Leu Xaa Xaa Ser Trp 
                245                 250                 255     


Gln Ala Leu Xaa Xaa Leu Xaa Xaa Asp Xaa Asp Ala Leu Leu Ala Xaa 
            260                 265                 270         


Ala Ala Lys Thr Met Xaa Gly Gly Ser Pro Leu Thr Gly His Leu Val 
        275                 280                 285             


Trp Gly Gln Ile Xaa Arg Ala Arg His Leu Ser Leu Ala Gln Val Xaa 
    290                 295                 300                 


Gln Met Glu Tyr Xaa Met Ser Leu Asn Cys Cys Arg His Pro Glu Phe 
305                 310                 315                 320 


Ala Glu Gly Val Arg Ala Arg Leu Ile Asp Lys Asp His Ala Pro His 
                325                 330                 335     


Trp His Trp Pro Asp Val Xaa Xaa Val Pro Xaa Gln Val Ile Ala Ala 
            340                 345                 350         


His Phe Xaa Pro Leu Asp Asp His Xaa Leu Ala Asp Leu Ala 
        355                 360                 365     


<210> 60
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (41)..(41)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (47)..(47)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (72)..(72)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (75)..(75)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (86)..(86)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (89)..(89)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (90)..(90)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (175)..(175)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (194)..(194)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (197)..(197)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (245)..(245)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (261)..(261)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (272)..(272)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (344)..(344)
<223> Any amino acid such as any naturally occurring amino acid

<400> 60
Met Xaa Val Thr Phe Glu Glu Arg Ala Ser Xaa His Gly Tyr Arg Ile 
1               5                   10                  15      


Gly Ile Ala Ser Leu Asp Ala Pro Ala Ser Leu Asn Ala Leu Ser Leu 
            20                  25                  30          


Pro Met Ile Xaa Ala Leu Xaa Asp Xaa Leu Xaa Xaa Trp Ala Xaa Asp 
        35                  40                  45              


Ala Xaa Ile Ala Cys Val Leu Leu Arg Gly Asn Gly Ser Lys Ala Phe 
    50                  55                  60                  


Cys Ala Gly Gly Asp Val Val Xaa Leu Ala Xaa Lys Cys Leu Ala Ser 
65                  70                  75                  80  


Pro Gly Glu Ala Pro Xaa Leu Ala Xaa Xaa Phe Phe Ala Arg Xaa Tyr 
                85                  90                  95      


Arg Leu Asp His Xaa Leu His Thr Tyr Pro Lys Pro Leu Ile Cys Trp 
            100                 105                 110         


Ala His Gly His Val Leu Gly Gly Gly Met Gly Leu Leu Gln Gly Ala 
        115                 120                 125             


Xaa Ile Arg Ile Val Thr Pro Ser Ser Arg Leu Ala Met Pro Glu Ile 
    130                 135                 140                 


Ser Ile Gly Leu Phe Pro Asp Val Gly Gly Ser His Phe Leu Ser Arg 
145                 150                 155                 160 


Leu Pro Gly Lys Leu Gly Leu Phe Phe Gly Leu Thr Ala Ser Xaa Leu 
                165                 170                 175     


Asn Ala Arg Asp Ala Leu Asp Leu Asn Leu Ala Asp Arg Phe Leu Leu 
            180                 185                 190         


Asp Xaa Gln Gln Xaa Ala Leu Ile Asp Gly Leu Ile Gln Leu Asn Trp 
        195                 200                 205             


Arg Glu Gln Pro Xaa Xaa Gln Leu His Ser Leu Leu Lys Ala Leu Glu 
    210                 215                 220                 


Gln Gln Ala Xaa Xaa Glu Leu Pro Ala Ala Gln Trp Leu Pro Arg Arg 
225                 230                 235                 240 


Xaa Xaa Leu Asp Xaa Leu Leu Asp Gln Ala Thr Leu Xaa Leu Ser Trp 
                245                 250                 255     


Gln Ala Leu Ala Xaa Leu Xaa Xaa Asp Xaa Asp Ala Leu Leu Ala Xaa 
            260                 265                 270         


Ala Ala Lys Thr Met Xaa Gly Gly Ser Pro Leu Thr Gly His Leu Val 
        275                 280                 285             


Trp Gly Gln Ile Arg Arg Ala Arg His Leu Ser Leu Ala Gln Val Phe 
    290                 295                 300                 


Gln Met Glu Tyr Xaa Met Ser Leu Asn Cys Cys Arg His Pro Glu Phe 
305                 310                 315                 320 


Ala Glu Gly Val Arg Ala Arg Leu Ile Asp Lys Asp His Ala Pro His 
                325                 330                 335     


Trp His Trp Pro Asp Val Asn Xaa Val Pro Glu Gln Val Ile Ala Ala 
            340                 345                 350         


His Phe Ala Pro Leu Asp Asp His Pro Leu Ala Asp Leu Ala 
        355                 360                 365     


<210> 61
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (36)..(36)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (39)..(39)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (50)..(50)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (95)..(95)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (101)..(101)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (129)..(129)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (213)..(213)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (214)..(214)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (228)..(228)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (241)..(241)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (242)..(242)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (263)..(263)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (264)..(264)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (266)..(266)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (278)..(278)
<223> Any amino acid such as any naturally occurring amino acid

<220>
<221> MOD_RES
<222> (309)..(309)
<223> Any amino acid such as any naturally occurring amino acid

<400> 61
Met Asn Val Thr Phe Glu Glu Arg Ala Ser Xaa His Gly Tyr Arg Ile 
1               5                   10                  15      


Gly Ile Ala Ser Leu Asp Ala Pro Ala Ser Leu Asn Ala Leu Ser Leu 
            20                  25                  30          


Pro Met Ile Xaa Ala Leu Xaa Asp Arg Leu Xaa Ala Trp Ala Glu Asp 
        35                  40                  45              


Ala Xaa Ile Ala Cys Val Leu Leu Arg Gly Asn Gly Ser Lys Ala Phe 
    50                  55                  60                  


Cys Ala Gly Gly Asp Val Val Gln Leu Ala Lys Lys Cys Leu Ala Ser 
65                  70                  75                  80  


Pro Gly Glu Ala Pro Glu Leu Ala Glu Arg Phe Phe Ala Arg Xaa Tyr 
                85                  90                  95      


Arg Leu Asp His Xaa Leu His Thr Tyr Pro Lys Pro Leu Ile Cys Trp 
            100                 105                 110         


Ala His Gly His Val Leu Gly Gly Gly Met Gly Leu Leu Gln Gly Ala 
        115                 120                 125             


Xaa Ile Arg Ile Val Thr Pro Ser Ser Arg Leu Ala Met Pro Glu Ile 
    130                 135                 140                 


Ser Ile Gly Leu Phe Pro Asp Val Gly Gly Ser His Phe Leu Ser Arg 
145                 150                 155                 160 


Leu Pro Gly Lys Leu Gly Leu Phe Phe Gly Leu Thr Ala Ser Pro Leu 
                165                 170                 175     


Asn Ala Arg Asp Ala Leu Asp Leu Asn Leu Ala Asp Arg Phe Leu Leu 
            180                 185                 190         


Asp Thr Gln Gln Asp Ala Leu Ile Asp Gly Leu Ile Gln Leu Asn Trp 
        195                 200                 205             


Arg Glu Gln Pro Xaa Xaa Gln Leu His Ser Leu Leu Lys Ala Leu Glu 
    210                 215                 220                 


Gln Gln Ala Xaa Ser Glu Leu Pro Ala Ala Gln Trp Leu Pro Arg Arg 
225                 230                 235                 240 


Xaa Xaa Leu Asp Ala Leu Leu Asp Gln Ala Thr Leu Pro Leu Ser Trp 
                245                 250                 255     


Gln Ala Leu Ala Ser Leu Xaa Xaa Asp Xaa Asp Ala Leu Leu Ala Lys 
            260                 265                 270         


Ala Ala Lys Thr Met Xaa Gly Gly Ser Pro Leu Thr Gly His Leu Val 
        275                 280                 285             


Trp Gly Gln Ile Arg Arg Ala Arg His Leu Ser Leu Ala Gln Val Phe 
    290                 295                 300                 


Gln Met Glu Tyr Xaa Met Ser Leu Asn Cys Cys Arg His Pro Glu Phe 
305                 310                 315                 320 


Ala Glu Gly Val Arg Ala Arg Leu Ile Asp Lys Asp His Ala Pro His 
                325                 330                 335     


Trp His Trp Pro Asp Val Asn Gln Val Pro Glu Gln Val Ile Ala Ala 
            340                 345                 350         


His Phe Ala Pro Leu Asp Asp His Pro Leu Ala Asp Leu Ala 
        355                 360                 365     


<210> 62
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (15)..(17)
<223> a, c, t, g, unknown or other

<220>
<221> misc_feature
<222> (15)..(17)
<223> This region encodes the desired E124 amino acid point mutation

<400> 62
aattttttac tgatnnntat tctttgaatt ttcaaatagc                             40


<210> 63
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (13)..(15)
<223> a, c, t, g, unknown or other

<220>
<221> misc_feature
<222> (13)..(15)
<223> This region encodes the desired E124 amino acid point mutation

<400> 63
ttcaaagaat aannnatcag taaaaaattt gatggacttg                             40


<210> 64
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 64
atgacgcaat ttgcatttgt gttccc                                            26


<210> 65
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 65
ttaaagctcg agcgccgct                                                    19


<210> 66
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
attgtataca at                                                           12

