                         SEQUENCE LISTING

<110>  ŵ΢Ƽ޹˾
 
<120>  ΢DNA

<130>  PCT2001050

<160>  13    

<170>  PatentIn version 3.3

<210>  1
<211>  28
<212>  PRT
<213>  FIXź

<400>  1

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys 
            20                  25              


<210>  2
<211>  18
<212>  PRT
<213>  FIXǰģpropeptide

<400>  2

Thr Val Phe Leu Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro 
1               5                   10                  15      


Lys Arg 
        


<210>  3
<211>  461
<212>  PRT
<213>  FIX

<400>  3

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  4
<211>  461
<212>  PRT
<213>  FIX-Paduaͻ

<400>  4

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  5
<211>  461
<212>  PRT
<213>  FIX-KLWͻ

<400>  5

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Lys Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Trp Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  6
<211>  19
<212>  PRT
<213>  FVIIIź

<400>  6

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser 
            


<210>  7
<211>  1457
<212>  PRT
<213>  BDD-FVIII

<400>  7

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             


Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 
    770                 775                 780                 


Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu 
785                 790                 795                 800 


Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 
                805                 810                 815     


Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 
            820                 825                 830         


Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 
        835                 840                 845             


Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 
    850                 855                 860                 


Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 
865                 870                 875                 880 


Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 
                885                 890                 895     


Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 
            900                 905                 910         


Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 
        915                 920                 925             


Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 
    930                 935                 940                 


Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 
945                 950                 955                 960 


Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 
                965                 970                 975     


Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 
            980                 985                 990         


Gly Arg Gln Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 
        995                 1000                 1005             


Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 
    1010                 1015                 1020             


Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 
    1040                 1045                 1050             


Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 
    1055                 1060                 1065             


Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 
    1070                 1075                 1080             


Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 
    1085                 1090                 1095             


Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 
    1100                 1105                 1110             


Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 
    1115                 1120                 1125             


Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 
    1130                 1135                 1140             


Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 
    1145                 1150                 1155             


Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 
    1160                 1165                 1170             


Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 
    1175                 1180                 1185             


Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 
    1190                 1195                 1200             


Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 
    1205                 1210                 1215             


Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 
    1220                 1225                 1230             


Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 
    1235                 1240                 1245             


Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 
    1250                 1255                 1260             


Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 
    1265                 1270                 1275             


Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 
    1280                 1285                 1290             


Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 
    1295                 1300                 1305             


Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 
    1310                 1315                 1320             


Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 
    1325                 1330                 1335             


Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 
    1340                 1345                 1350             


Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 
    1355                 1360                 1365             


Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 
    1370                 1375                 1380             


Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 
    1385                 1390                 1395             


Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 
    1400                 1405                 1410             


Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 
    1415                 1420                 1425             


Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 
    1430                 1435                 1440             


Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr 
    1445                 1450                 1455         


<210>  8
<211>  1470
<212>  PRT
<213>  BDD-FVIII-FDͻ

<400>  8

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ala Thr Asn Val 
        755                 760                 765             


Ser Asn Asn Ser Asn Thr Ser Asn Asp Ser Asn Val Ser Pro Pro Val 
    770                 775                 780                 


Leu Lys Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
785                 790                 795                 800 


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
                805                 810                 815     


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
            820                 825                 830         


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
        835                 840                 845             


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
    850                 855                 860                 


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
865                 870                 875                 880 


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
                885                 890                 895     


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
            900                 905                 910         


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
        915                 920                 925             


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
    930                 935                 940                 


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
945                 950                 955                 960 


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
                965                 970                 975     


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
            980                 985                 990         


Leu Leu Val Cys His Thr Asn Thr  Leu Asn Pro Ala His  Gly Arg Gln 
        995                 1000                 1005             


Val Thr  Val Gln Glu Phe Ala  Leu Phe Phe Thr Ile  Phe Asp Glu 
    1010                 1015                 1020             


Thr Lys  Ser Trp Tyr Phe Thr  Glu Asn Met Glu Arg  Asn Cys Arg 
    1025                 1030                 1035             


Ala Pro  Cys Asn Ile Gln Met  Glu Asp Pro Thr Phe  Lys Glu Asn 
    1040                 1045                 1050             


Tyr Arg  Phe His Ala Ile Asn  Gly Tyr Ile Met Asp  Thr Leu Pro 
    1055                 1060                 1065             


Gly Leu  Val Met Ala Gln Asp  Gln Arg Ile Arg Trp  Tyr Leu Leu 
    1070                 1075                 1080             


Ser Met  Gly Ser Asn Glu Asn  Ile His Ser Ile His  Phe Ser Gly 
    1085                 1090                 1095             


His Val  Phe Thr Val Arg Lys  Lys Glu Glu Tyr Lys  Met Ala Leu 
    1100                 1105                 1110             


Tyr Asn  Leu Tyr Pro Gly Val  Phe Glu Thr Val Glu  Met Leu Pro 
    1115                 1120                 1125             


Ser Lys  Ala Gly Ile Trp Arg  Val Glu Cys Leu Ile  Gly Glu His 
    1130                 1135                 1140             


Leu His  Ala Gly Met Ser Thr  Leu Phe Leu Val Tyr  Ser Asn Lys 
    1145                 1150                 1155             


Cys Gln  Thr Pro Leu Gly Met  Ala Ser Gly His Ile  Arg Asp Phe 
    1160                 1165                 1170             


Gln Ile  Thr Ala Ser Gly Gln  Tyr Gly Gln Trp Ala  Pro Lys Leu 
    1175                 1180                 1185             


Ala Arg  Leu His Tyr Ser Gly  Ser Ile Asn Ala Trp  Ser Thr Lys 
    1190                 1195                 1200             


Glu Pro  Phe Ser Trp Ile Lys  Val Asp Leu Leu Ala  Pro Met Ile 
    1205                 1210                 1215             


Ile His  Gly Ile Lys Thr Gln  Gly Ala Arg Gln Lys  Phe Ser Ser 
    1220                 1225                 1230             


Leu Tyr  Ile Ser Gln Phe Ile  Ile Met Tyr Ser Leu  Asp Gly Lys 
    1235                 1240                 1245             


Lys Trp  Gln Thr Tyr Arg Gly  Asn Ser Thr Gly Thr  Leu Met Val 
    1250                 1255                 1260             


Phe Phe  Gly Asn Val Asp Ser  Ser Gly Ile Lys His  Asn Ile Phe 
    1265                 1270                 1275             


Asn Pro  Pro Ile Ile Ala Arg  Tyr Ile Arg Leu His  Pro Thr His 
    1280                 1285                 1290             


Tyr Ser  Ile Arg Ser Thr Leu  Arg Met Glu Leu Met  Gly Cys Asp 
    1295                 1300                 1305             


Leu Asn  Ser Cys Ser Met Pro  Leu Gly Met Glu Ser  Lys Ala Ile 
    1310                 1315                 1320             


Ser Asp  Ala Gln Ile Thr Ala  Ser Ser Tyr Phe Thr  Asn Met Phe 
    1325                 1330                 1335             


Ala Thr  Trp Ser Pro Ser Lys  Ala Arg Leu His Leu  Gln Gly Arg 
    1340                 1345                 1350             


Ser Asn  Ala Trp Arg Pro Gln  Val Asn Asn Pro Lys  Glu Trp Leu 
    1355                 1360                 1365             


Gln Val  Asp Phe Gln Lys Thr  Met Lys Val Thr Gly  Val Thr Thr 
    1370                 1375                 1380             


Gln Gly  Val Lys Ser Leu Leu  Thr Ser Met Tyr Val  Lys Glu Phe 
    1385                 1390                 1395             


Leu Ile  Ser Ser Ser Gln Asp  Gly His Gln Trp Thr  Leu Phe Phe 
    1400                 1405                 1410             


Gln Asn  Gly Lys Val Lys Val  Phe Gln Gly Asn Gln  Asp Ser Phe 
    1415                 1420                 1425             


Thr Pro  Val Val Asn Ser Leu  Asp Pro Pro Leu Leu  Thr Arg Tyr 
    1430                 1435                 1440             


Leu Arg  Ile His Pro Gln Ser  Trp Val His Gln Ile  Ala Leu Arg 
    1445                 1450                 1455             


Met Glu  Val Leu Gly Cys Glu  Ala Gln Asp Leu Tyr  
    1460                 1465                 1470 


<210>  9
<211>  1386
<212>  DNA
<213>  FIX

<400>  9
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta     60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt    120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt    180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac    240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat    300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc    360

tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga    420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga    480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga    540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac    600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca    660

tttaatgact tcacgcgtgt tgttggtgga gaagatgcca aaccaggtca attcccttgg    720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa    780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgccggc    840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt    900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa    960

ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa   1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc   1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc   1140

acatgtcttc gatctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat   1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa   1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa   1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc   1380

acttaa                                                              1386


<210>  10
<211>  1386
<212>  DNA
<213>  FIX-Paduaͻ

<400>  10
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta     60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt    120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt    180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac    240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat    300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc    360

tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga    420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga    480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga    540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac    600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca    660

tttaatgact tcacgcgtgt tgttggtgga gaagatgcca aaccaggtca attcccttgg    720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa    780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgccggc    840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt    900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa    960

ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa   1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc   1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc   1140

acatgtcttc tatctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat   1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa   1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa   1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc   1380

acttaa                                                              1386


<210>  11
<211>  1386
<212>  DNA
<213>  FIX-KLWͻ

<400>  11
atgcagaggg tgaacatgat catggccgag agccctggcc tgatcacaat ctgcctgctg     60

ggctatctgc tgtccgccga gtgtaccgtg ttcctggacc acgagaacgc caataagatc    120

ctgaacaggc caaagagata caattctggc aagctggagg agtttaagca gggcaacctg    180

gagcgggagt gcatggagga gaagtgtagc ttcgaggagg ccagggaggt gtttgagaat    240

accgagagaa ccacagagtt ctggaagcag tatgtggacg gcgatcagtg cgagtccaac    300

ccctgtctga atggcggctc ttgcaaggac gatatcaaca gctacgagtg ctggtgtcct    360

ttcggctttg agggcaagaa ttgcgagctg gacgtgacat gtaacatcaa gaatggcagg    420

tgcgagcagt tttgtaagaa ctccgccgat aataaggtgg tgtgctcttg taccgagggc    480

tatagactgg ccgagaacca gaagtcttgc gagccagcag tgccattccc ttgtggacgg    540

gtgagcgtgt cccagacctc taagctgaca cgcgccgaga ccgtgtttcc cgacgtggat    600

tacgtgaata gcacagaggc cgagaccatc ctggacaaca tcacccagtc tacacagagc    660

ttcaatgact ttacaagggt ggtgggagga gaggatgcaa agccaggcca gttcccctgg    720

caggtggtgc tgaacggcaa ggtggatgcc ttttgcggcg gcagcatcgt gaatgagaag    780

tggatcgtga ccgcagcaca ctgcgtggag acaggcgtga agatcaccgt ggtggccggc    840

gagcacaaca tcgaggagac cgagcacaca gagcagaagc ggaatgtgat ccgcatcatc    900

ccccaccaca actacaatgc cgccatcaac aagtataatc acgacatcgc cctgctggag    960

ctggatgagc ctctggtgct gaactcctac gtgacaccaa tctgcatcgc cgacaaggag   1020

tataccaata tcttcctgaa gtttggatcc ggatacgtgt ctggatgggg aagggtgttc   1080

cacaagggca gaagcgccct ggtgctgcag tatctgaggg tgccactggt ggatagggca   1140

acctgtctgc tgtccaccaa gtttacaatc tacaacaata tgttctgcgc aggatttcac   1200

gagggaggaa gggacagctg tcagggcgat tccggaggac ctcacgtgac agaggtggag   1260

ggcacatggt tcctgaccgg catcatctcc tggggcgagg agtgtgccat gaagggcaag   1320

tacggcatct ataccaaggt gtctcgctac gtgaactgga tcaaggagaa gaccaagctg   1380

acatga                                                              1386


<210>  12
<211>  4374
<212>  DNA
<213>  BDD-FVIII

<400>  12
atgcagattg agctgagcac ctgcttcttc ctgtgcctgc tgaggttctg cttctctgcc     60

accaggagat actacctggg ggctgtggag ctgagctggg actacatgca gtctgacctg    120

ggggagctgc ctgtggatgc caggttcccc cccagagtgc ccaagagctt ccccttcaac    180

acctctgtgg tgtacaagaa gaccctgttt gtggagttca ctgaccacct gttcaacatt    240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc tgaggtgtat    300

gacactgtgg tgatcaccct gaagaacatg gccagccacc ctgtgagcct gcatgctgtg    360

ggggtgagct actggaaggc ctctgagggg gctgagtatg atgaccagac cagccagagg    420

gagaaggagg atgacaaggt gttccctggg ggcagccaca cctatgtgtg gcaggtgctg    480

aaggagaatg gccccatggc ctctgacccc ctgtgcctga cctacagcta cctgagccat    540

gtggacctgg tgaaggacct gaactctggc ctgattgggg ccctgctggt gtgcagggag    600

ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gtttgctgtg    660

tttgatgagg gcaagagctg gcactctgaa accaagaaca gcctgatgca ggacagggat    720

gctgcctctg ccagggcctg gcccaagatg cacactgtga atggctatgt gaacaggagc    780

ctgcctggcc tgattggctg ccacaggaag tctgtgtact ggcatgtgat tggcatgggc    840

accacccctg aggtgcacag catcttcctg gagggccaca ccttcctggt caggaaccac    900

aggcaggcca gcctggagat cagccccatc accttcctga ctgcccagac cctgctgatg    960

gacctgggcc agttcctgct gttctgccac atcagcagcc accagcatga tggcatggag   1020

gcctatgtga aggtggacag ctgccctgag gagccccagc tgaggatgaa gaacaatgag   1080

gaggctgagg actatgatga tgacctgact gactctgaga tggatgtggt gaggtttgat   1140

gatgacaaca gccccagctt catccagatc aggtctgtgg ccaagaagca ccccaagacc   1200

tgggtgcact acattgctgc tgaggaggag gactgggact atgcccccct ggtgctggcc   1260

cctgatgaca ggagctacaa gagccagtac ctgaacaatg gcccccagag gattggcagg   1320

aagtacaaga aggtcaggtt catggcctac actgatgaaa ccttcaagac cagggaggcc   1380

atccagcatg agtctggcat cctgggcccc ctgctgtatg gggaggtggg ggacaccctg   1440

ctgatcatct tcaagaacca ggccagcagg ccctacaaca tctaccccca tggcatcact   1500

gatgtgaggc ccctgtacag caggaggctg cccaaggggg tgaagcacct gaaggacttc   1560

cccatcctgc ctggggagat cttcaagtac aagtggactg tgactgtgga ggatggcccc   1620

accaagtctg accccaggtg cctgaccaga tactacagca gctttgtgaa catggagagg   1680

gacctggcct ctggcctgat tggccccctg ctgatctgct acaaggagtc tgtggaccag   1740

aggggcaacc agatcatgtc tgacaagagg aatgtgatcc tgttctctgt gtttgatgag   1800

aacaggagct ggtacctgac tgagaacatc cagaggttcc tgcccaaccc tgctggggtg   1860

cagctggagg accctgagtt ccaggccagc aacatcatgc acagcatcaa tggctatgtg   1920

tttgacagcc tgcagctgtc tgtgtgcctg catgaggtgg cctactggta catcctgagc   1980

attggggccc agactgactt cctgtctgtg ttcttctctg gctacacctt caagcacaag   2040

atggtgtatg aggacaccct gaccctgttc cccttctctg gggagactgt gttcatgagc   2100

atggagaacc ctggcctgtg gattctgggc tgccacaact ctgacttcag gaacaggggc   2160

atgactgccc tgctgaaagt ctccagctgt gacaagaaca ctggggacta ctatgaggac   2220

agctatgagg acatctctgc ctacctgctg agcaagaaca atgccattga gcccaggagc   2280

ttcagccaga atcccccagt gctgaagagg caccagaggg agatcaccag gaccaccctg   2340

cagtctgacc aggaggagat tgactatgat gacaccatct ctgtggagat gaagaaggag   2400

gactttgaca tctacgacga ggacgagaac cagagcccca ggagcttcca gaagaagacc   2460

aggcactact tcattgctgc tgtggagagg ctgtgggact atggcatgag cagcagcccc   2520

catgtgctga ggaacagggc ccagtctggc tctgtgcccc agttcaagaa ggtggtgttc   2580

caggagttca ctgatggcag cttcacccag cccctgtaca gaggggagct gaatgagcac   2640

ctgggcctgc tgggccccta catcagggct gaggtggagg acaacatcat ggtgaccttc   2700

aggaaccagg ccagcaggcc ctacagcttc tacagcagcc tgatcagcta tgaggaggac   2760

cagaggcagg gggctgagcc caggaagaac tttgtgaagc ccaatgaaac caagacctac   2820

ttctggaagg tgcagcacca catggccccc accaaggatg agtttgactg caaggcctgg   2880

gcctacttct ctgatgtgga cctggagaag gatgtgcact ctggcctgat tggccccctg   2940

ctggtgtgcc acaccaacac cctgaaccct gcccatggca ggcaggtgac tgtgcaggag   3000

tttgccctgt tcttcaccat ctttgatgaa accaagagct ggtacttcac tgagaacatg   3060

gagaggaact gcagggcccc ctgcaacatc cagatggagg accccacctt caaggagaac   3120

tacaggttcc atgccatcaa tggctacatc atggacaccc tgcctggcct ggtgatggcc   3180

caggaccaga ggatcaggtg gtacctgctg agcatgggca gcaatgagaa catccacagc   3240

atccacttct ctggccatgt gttcactgtg aggaagaagg aggagtacaa gatggccctg   3300

tacaacctgt accctggggt gtttgagact gtggagatgc tgcccagcaa ggctggcatc   3360

tggagggtgg agtgcctgat tggggagcac ctgcatgctg gcatgagcac cctgttcctg   3420

gtgtacagca acaagtgcca gacccccctg ggcatggcct ctggccacat cagggacttc   3480

cagatcactg cctctggcca gtatggccag tgggccccca agctggccag gctgcactac   3540

tctggcagca tcaatgcctg gagcaccaag gagcccttca gctggatcaa ggtggacctg   3600

ctggccccca tgatcatcca tggcatcaag acccaggggg ccaggcagaa gttcagcagc   3660

ctgtacatca gccagttcat catcatgtac agcctggatg gcaagaagtg gcagacctac   3720

aggggcaaca gcactggcac cctgatggtg ttctttggca atgtggacag ctctggcatc   3780

aagcacaaca tcttcaaccc ccccatcatt gccagataca tcaggctgca ccccacccac   3840

tacagcatca ggagcaccct gaggatggag ctgatgggct gtgacctgaa cagctgcagc   3900

atgcccctgg gcatggagag caaggccatc tctgatgccc agatcactgc cagcagctac   3960

ttcaccaaca tgtttgccac ctggagcccc agcaaggcca ggctgcacct gcagggcagg   4020

agcaatgcct ggaggcccca ggtcaacaac cccaaggagt ggctgcaggt ggacttccag   4080

aagaccatga aggtgactgg ggtgaccacc cagggggtga agagcctgct gaccagcatg   4140

tatgtgaagg agttcctgat cagcagcagc caggatggcc accagtggac cctgttcttc   4200

cagaatggca aggtgaaggt gttccagggc aaccaggaca gcttcacccc tgtggtgaac   4260

agcctggacc cccccctgct gaccagatac ctgaggattc acccccagag ctgggtgcac   4320

cagattgccc tgaggatgga ggtgctgggc tgtgaggccc aggacctgta ctga         4374


<210>  13
<211>  4413
<212>  DNA
<213>  BDD-FVIII-FDͻ

<400>  13
atgcagattg agctgagcac ctgcttcttc ctgtgcctgc tgaggttctg cttctctgcc     60

accaggagat actacctggg ggctgtggag ctgagctggg actacatgca gtctgacctg    120

ggggagctgc ctgtggatgc caggttcccc cccagagtgc ccaagagctt ccccttcaac    180

acctctgtgg tgtacaagaa gaccctgttt gtggagttca ctgaccacct gttcaacatt    240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc tgaggtgtat    300

gacactgtgg tgatcaccct gaagaacatg gccagccacc ctgtgagcct gcatgctgtg    360

ggggtgagct actggaaggc ctctgagggg gctgagtatg atgaccagac cagccagagg    420

gagaaggagg atgacaaggt gttccctggg ggcagccaca cctatgtgtg gcaggtgctg    480

aaggagaatg gccccatggc ctctgacccc ctgtgcctga cctacagcta cctgagccat    540

gtggacctgg tgaaggacct gaactctggc ctgattgggg ccctgctggt gtgcagggag    600

ggcagcctgg ccaaggagaa gacccagacc ctgcacaagt tcatcctgct gtttgctgtg    660

tttgatgagg gcaagagctg gcactctgaa accaagaaca gcctgatgca ggacagggat    720

gctgcctctg ccagggcctg gcccaagatg cacactgtga atggctatgt gaacaggagc    780

ctgcctggcc tgattggctg ccacaggaag tctgtgtact ggcatgtgat tggcatgggc    840

accacccctg aggtgcacag catcttcctg gagggccaca ccttcctggt caggaaccac    900

aggcaggcca gcctggagat cagccccatc accttcctga ctgcccagac cctgctgatg    960

gacctgggcc agttcctgct gttctgccac atcagcagcc accagcatga tggcatggag   1020

gcctatgtga aggtggacag ctgccctgag gagccccagc tgaggatgaa gaacaatgag   1080

gaggctgagg actatgatga tgacctgact gactctgaga tggatgtggt gaggtttgat   1140

gatgacaaca gccccagctt catccagatc aggtctgtgg ccaagaagca ccccaagacc   1200

tgggtgcact acattgctgc tgaggaggag gactgggact atgcccccct ggtgctggcc   1260

cctgatgaca ggagctacaa gagccagtac ctgaacaatg gcccccagag gattggcagg   1320

aagtacaaga aggtcaggtt catggcctac actgatgaaa ccttcaagac cagggaggcc   1380

atccagcatg agtctggcat cctgggcccc ctgctgtatg gggaggtggg ggacaccctg   1440

ctgatcatct tcaagaacca ggccagcagg ccctacaaca tctaccccca tggcatcact   1500

gatgtgaggc ccctgtacag caggaggctg cccaaggggg tgaagcacct gaaggacttc   1560

cccatcctgc ctggggagat cttcaagtac aagtggactg tgactgtgga ggatggcccc   1620

accaagtctg accccaggtg cctgaccaga tactacagca gctttgtgaa catggagagg   1680

gacctggcct ctggcctgat tggccccctg ctgatctgct acaaggagtc tgtggaccag   1740

aggggcaacc agatcatgtc tgacaagagg aatgtgatcc tgttctctgt gtttgatgag   1800

aacaggagct ggtacctgac tgagaacatc cagaggttcc tgcccaaccc tgctggggtg   1860

cagctggagg accctgagtt ccaggccagc aacatcatgc acagcatcaa tggctatgtg   1920

tttgacagcc tgcagctgtc tgtgtgcctg catgaggtgg cctactggta catcctgagc   1980

attggggccc agactgactt cctgtctgtg ttcttctctg gctacacctt caagcacaag   2040

atggtgtatg aggacaccct gaccctgttc cccttctctg gggagactgt gttcatgagc   2100

atggagaacc ctggcctgtg gattctgggc tgccacaact ctgacttcag gaacaggggc   2160

atgactgccc tgctgaaagt ctccagctgt gacaagaaca ctggggacta ctatgaggac   2220

agctatgagg acatctctgc ctacctgctg agcaagaaca atgccattga gcccaggagc   2280

ttcagccaga atgccactaa tgtgtctaac aacagcaaca ccagcaatga cagcaatgtg   2340

tctcccccag tgctgaagga gatcaccagg accaccctgc agtctgacca ggaggagatt   2400

gactatgatg acaccatctc tgtggagatg aagaaggagg actttgacat ctacgacgag   2460

gacgagaacc agagccccag gagcttccag aagaagacca ggcactactt cattgctgct   2520

gtggagaggc tgtgggacta tggcatgagc agcagccccc atgtgctgag gaacagggcc   2580

cagtctggct ctgtgcccca gttcaagaag gtggtgttcc aggagttcac tgatggcagc   2640

ttcacccagc ccctgtacag aggggagctg aatgagcacc tgggcctgct gggcccctac   2700

atcagggctg aggtggagga caacatcatg gtgaccttca ggaaccaggc cagcaggccc   2760

tacagcttct acagcagcct gatcagctat gaggaggacc agaggcaggg ggctgagccc   2820

aggaagaact ttgtgaagcc caatgaaacc aagacctact tctggaaggt gcagcaccac   2880

atggccccca ccaaggatga gtttgactgc aaggcctggg cctacttctc tgatgtggac   2940

ctggagaagg atgtgcactc tggcctgatt ggccccctgc tggtgtgcca caccaacacc   3000

ctgaaccctg cccatggcag gcaggtgact gtgcaggagt ttgccctgtt cttcaccatc   3060

tttgatgaaa ccaagagctg gtacttcact gagaacatgg agaggaactg cagggccccc   3120

tgcaacatcc agatggagga ccccaccttc aaggagaact acaggttcca tgccatcaat   3180

ggctacatca tggacaccct gcctggcctg gtgatggccc aggaccagag gatcaggtgg   3240

tacctgctga gcatgggcag caatgagaac atccacagca tccacttctc tggccatgtg   3300

ttcactgtga ggaagaagga ggagtacaag atggccctgt acaacctgta ccctggggtg   3360

tttgagactg tggagatgct gcccagcaag gctggcatct ggagggtgga gtgcctgatt   3420

ggggagcacc tgcatgctgg catgagcacc ctgttcctgg tgtacagcaa caagtgccag   3480

acccccctgg gcatggcctc tggccacatc agggacttcc agatcactgc ctctggccag   3540

tatggccagt gggcccccaa gctggccagg ctgcactact ctggcagcat caatgcctgg   3600

agcaccaagg agcccttcag ctggatcaag gtggacctgc tggcccccat gatcatccat   3660

ggcatcaaga cccagggggc caggcagaag ttcagcagcc tgtacatcag ccagttcatc   3720

atcatgtaca gcctggatgg caagaagtgg cagacctaca ggggcaacag cactggcacc   3780

ctgatggtgt tctttggcaa tgtggacagc tctggcatca agcacaacat cttcaacccc   3840

cccatcattg ccagatacat caggctgcac cccacccact acagcatcag gagcaccctg   3900

aggatggagc tgatgggctg tgacctgaac agctgcagca tgcccctggg catggagagc   3960

aaggccatct ctgatgccca gatcactgcc agcagctact tcaccaacat gtttgccacc   4020

tggagcccca gcaaggccag gctgcacctg cagggcagga gcaatgcctg gaggccccag   4080

gtcaacaacc ccaaggagtg gctgcaggtg gacttccaga agaccatgaa ggtgactggg   4140

gtgaccaccc agggggtgaa gagcctgctg accagcatgt atgtgaagga gttcctgatc   4200

agcagcagcc aggatggcca ccagtggacc ctgttcttcc agaatggcaa ggtgaaggtg   4260

ttccagggca accaggacag cttcacccct gtggtgaaca gcctggaccc ccccctgctg   4320

accagatacc tgaggattca cccccagagc tgggtgcacc agattgccct gaggatggag   4380

gtgctgggct gtgaggccca ggacctgtac tga                                4413


