                         SEQUENCE LISTING

<110>  POSEIDA THERAPEUTICS, INC.
 
<120>  ALLOGENEIC CELL COMPOSITIONS AND METHODS OF USE

<130>  POTH-055/001WO 325002-2475

<150>  US 62/896,495
<151>  2019-09-05

<150>  US 62/976,536
<151>  2020-02-14

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp 
            180                 185 


<210>  2
<211>  555
<212>  DNA
<213>  Homo sapiens

<400>  2
aaagagatca caaacgccct ggaaacctgg ggagccctcg gccaggatat taacctggac       60

atccccagct tccagatgag cgacgacatc gatgacatca agtgggagaa aaccagcgac      120

aagaagaaga tcgcccagtt ccggaaagag aaagagacat tcaaagagaa ggacacctac      180

aagctgttca agaacggcac cctgaagatc aagcacctga aaaccgacga ccaggacatc      240

tataaggtgt ccatctacga caccaagggc aagaacgtgc tggaaaagat cttcgacctc      300

aagatccaag agcgggtgtc caagcctaag atcagctgga cctgcatcaa caccacactg      360

acctgcgaag tgatgaacgg cacagacccc gagctgaacc tgtaccagga tggcaaacac      420

ctgaagctga gccagcgcgt gatcacccac aagtggacaa caagcctgag cgccaagttc      480

aagtgcaccg ccggaaacaa agtgtctaaa gagtccagcg tcgagcccgt gtcttgccct      540

gaaaaaggac tggac                                                       555


<210>  3
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 Extracellular domain with D111H mutation

<400>  3

Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp 
            180                 185 


<210>  4
<211>  555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2 extracellular domain witha  D111H mutation

<400>  4
aaagaaatca cgaatgcatt ggaaacctgg ggagccctcg gccaggatat taacctggac       60

atccccagct tccagatgag cgacgacatc gatgacatca agtgggagaa aaccagcgac      120

aagaagaaga tcgcccagtt ccggaaagag aaagagacat tcaaagagaa ggacacctac      180

aagctgttca agaacggcac cctgaagatc aagcacctga aaaccgacga ccaggacatc      240

tataaggtgt ccatctacca caccaagggc aagaacgtgc tggaaaagat cttcgacctc      300

aagatccaag agcgggtgtc caagcctaag atcagctgga cctgcatcaa caccacactg      360

acctgcgaag tgatgaacgg cacagacccc gagctgaacc tgtaccagga tggcaaacac      420

ctgaagctga gccagcgcgt gatcacccac aagtggacaa caagcctgag cgccaagttc      480

aagtgcaccg ccggaaacaa agtgtctaaa gagtccagcg tcgagcccgt gtcttgccct      540

gaaaaaggac tggac                                                       555


<210>  5
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser 
            20                  


<210>  6
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  6
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt cc                                                           72


<210>  7
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  8
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  8
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cct                                                                     63


<210>  9
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  9

Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val 
1               5                   10                  15      


Phe Val Ala Leu Leu Val Phe Tyr Ile Thr 
            20                  25      


<210>  10
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  10
atctacctga tcatcggcat ctgtggcggc ggatccctgc tgatggtgtt tgtggctctg       60

ctggtgttct acatcacc                                                     78


<210>  11
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  12
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  12
agagtgaaat tcagccgcag cgccgatgct cctgcctata agcagggaca gaaccagctg       60

tacaacgagc tgaatctggg gcgcagagaa gagtacgatg tgctggacaa gcggagaggc      120

agagatcctg agatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtataat      180

gagctgcaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgagcgc      240

agaagaggca agggacacga tggactgtat cagggcctga gcaccgccac caaggatacc      300

tatgatgccc tgcacatgca ggccctgcct ccaaga                                336


<210>  13
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser Asn 
        115     


<210>  14
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  14
aagcggaaga agcagcggag cagacggaac gacgaggaac tggaaacacg ggcccataga       60

gtggccaccg aggaaagagg cagaaagccc caccagattc cagccagcac accccagaat      120

cctgccacct ctcaacaccc tccacctcca cctggacaca gatctcaggc cccatctcac      180

agacctccac cacctggtca tcgggtgcag caccagcctc agaaaagacc tcctgctcct      240

agcggcacac aggtgcacca gcaaaaagga cctccactgc ctcggcctag agtgcagcct      300

aaacctcctc atggcgccgc tgagaacagc ctgtctccaa gcagcaac                   348


<210>  15
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  16
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  16
agaagcaagc ggagccggct gctgcacagc gactacatga acatgacccc tagacggccc       60

ggacctacca gaaagcacta ccagccttac gctcctccta gagacttcgc cgcctaccgg      120

tcc                                                                    123


<210>  17
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  17

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  18
<211>  126
<212>  DNA
<213>  homo sapiens

<400>  18
aagcggggca gaaagaagct gctgtacatc ttcaagcagc ccttcatgcg gcccgtgcag       60

accacacaag aggaagatgg ctgctcctgc agattccccg aggaagaaga aggcggctgc      120

gagctg                                                                 126


<210>  19
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  19

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
65                  70                  75                  80  


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                85                  90                  95      


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            100                 105                 110         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        115                 120                 125             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    130                 135                 140                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
145                 150                 155                 160 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                165                 170                 175     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Gln 
        195 


<210>  20
<211>  585
<212>  DNA
<213>  Homo sapiens

<400>  20
aagaagcgga tcaagcccat cgtgtggccc agcctgcctg accacaagaa aaccctggaa       60

cacctgtgca agaagccccg gaagaacctg aatgtgtcct tcaatcccga gagcttcctg      120

gactgccaga tccacagagt ggacgacatc caggccagag atgaggtgga aggctttctg      180

caggacacct ttccacagca gctggaagag agcgagaagc agagactcgg cggagatgtg      240

cagagcccta attgccctag cgaggacgtg gtcatcaccc ctgagagctt cggcagagat      300

agcagcctga catgtctggc cggcaatgtg tccgcctgtg atgcccctat cctgagcagc      360

agcagaagcc tggattgcag agagagcgga aagaacggcc ctcatgtgta tcaggacctg      420

ctgctgagcc tgggcaccac caattctaca ctgcctccac cattcagcct gcagagcggc      480

atcctgacac tgaaccctgt tgctcagggc cagccaatcc tgacaagcct gggctccaat      540

caagaagagg cctacgtcac catgtccagc ttctaccaga accag                      585


<210>  21
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
1               5                   10                  15      


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
            20                  25                  30          


Glu Asn Cys Ser His His Leu 
        35                  


<210>  22
<211>  117
<212>  DNA
<213>  Homo sapiens

<400>  22
aagagccggc agacacctcc tctggccagc gtggaaatgg aagccatgga agctctgcct       60

gtgacctggg gcacaagcag cagagatgag gacctggaaa actgcagcca ccacctg         117


<210>  23
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Leu Lys Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala 
1               5                   10                  15      


Val Pro Ser Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser 
            20                  25                  30          


Gly Asp Phe Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu 
        35                  40                  45              


Glu Leu Gly Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr 
    50                  55                  60                  


Ser Cys His Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu 
65                  70                  75                  80  


Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro 
                85                  90                  95      


Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu 
            100                 105                 110         


Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val 
        115                 120                 125             


Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp 
    130                 135                 140                 


Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly 
                165                 170                 175     


Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu 
            180                 185                 190         


Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly 
        195                 200                 205             


Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu 
    210                 215                 220                 


Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly 
225                 230                 235                 240 


Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser 
                245                 250                 255     


Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val 
            260                 265                 270         


Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
        275                 280                 285 


<210>  24
<211>  855
<212>  DNA
<213>  Homo sapiens

<400>  24
agcctgaaaa cacacccact ctggcggctg tggaagaaaa tctgggccgt gccatctcct       60

gagcggttct tcatgcctct gtacaagggc tgcagcggcg acttcaagaa atgggtcgga      120

gcccctttta ccggcagctc tctggaactt ggaccttgga gccctgaggt gcccagcaca      180

ctggaagtgt acagctgtca ccctcctaga agccccgcca agagactgca gctgacagag      240

ctgcaagagc ctgccgagct ggtggaatct gatggcgtgc ccaagcctag cttctggccc      300

acagctcaga atagcggcgg ctctgcctac agcgaggaaa gggatagacc ttacggcctg      360

gtgtctatcg acaccgtgac cgtgctggat gccgagggac cttgtacatg gccttgcagc      420

tgcgaggacg atggctaccc tgctctggat ctggacgcag gccttgagcc ttctccagga      480

ctggaagatc ctctgctgga cgccggaaca accgtgctgt cttgtggctg tgtgtctgcc      540

ggatctcctg gacttggagg ccctctggga agcctgctgg atagactgaa acctcctctg      600

gccgacggcg aagattgggc tggtggactt ccttggggcg gaagatctcc aggcggagtg      660

tctgagtctg aagccggttc tccactggcc ggcctggaca tggatacctt cgattctggc      720

ttcgtgggca gcgactgtag cagccctgtg gaatgcgact tcacaagccc tggcgacgag      780

ggcccaccta gaagctatct gagacagtgg gtcgtgatcc ctccacctct gtctagtcct      840

ggacctcagg ccagc                                                       855


<210>  25
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  25

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  26
<211>  114
<212>  DNA
<213>  Homo sapiens

<400>  26
tgttggctga ccaagaaaaa gtacagcagc agcgtgcacg accccaacgg cgagtacatg       60

ttcatgagag ccgtgaacac cgccaagaag tccagactga ccgacgtgac cctg            114


<210>  27
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  28
<211>  144
<212>  DNA
<213>  Homo sapiens

<400>  28
cagcggcgga agtacagaag caacaagggc gagagccccg tggaacctgc cgagccttgt       60

cactacagct gccccagaga ggaagagggc agcacaatcc ccatccaaga ggactacaga      120

aagcccgagc ctgcctgctc tccc                                             144


<210>  29
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  30
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  30
gccctgtacc tgctgcggcg ggatcaaaga ttgcctcctg acgctcacaa gcctccaggc       60

ggaggcagct ttagaacccc tatccaagag gaacaggctg acgcccacag caccctggcc      120

aagatc                                                                 126


<210>  31
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Leu Gly Leu His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro 
1               5                   10                  15      


Arg Glu Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala 
            20                  25                  30          


Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu 
        35                  40                  45              


Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
    50                  55              


<210>  32
<211>  180
<212>  DNA
<213>  Homo sapiens

<400>  32
cagctgggac tgcacatctg gcagctgaga agccagtgca tgtggcccag agagacacag       60

ctgctgctgg aagtgcctcc tagcaccgag gatgccagaa gctgtcagtt ccccgaggaa      120

gagagaggcg agagatccgc cgaggaaaaa ggcagactgg gcgacctgtg ggtccgagtg      180


<210>  33
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn Arg 
            340                 345                 350         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        355                 360                 365             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    370                 375                 380                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
385                 390                 395                 400 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                405                 410                 415     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            420                 425                 430         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        435                 440                 445             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460             


<210>  34
<211>  1389
<212>  DNA
<213>  Homo sapiens

<400>  34
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagagat cacaaacgcc ctggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac gacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

agcctgctga tggtgtttgt ggctctgctg gtgttctaca tcaccaagcg gaagaagcag      720

cggagcagac ggaacgacga ggaactggaa acacgggccc atagagtggc caccgaggaa      780

agaggcagaa agccccacca gattccagcc agcacacccc agaatcctgc cacctctcaa      840

caccctccac ctccacctgg acacagatct caggccccat ctcacagacc tccaccacct      900

ggtcatcggg tgcagcacca gcctcagaaa agacctcctg ctcctagcgg cacacaggtg      960

caccagcaaa aaggacctcc actgcctcgg cctagagtgc agcctaaacc tcctcatggc     1020

gccgctgaga acagcctgtc tccaagcagc aacagagtga agttcagccg cagcgccgat     1080

gctcctgcct ataagcaggg acagaaccag ctgtacaacg agctgaatct ggggcgcaga     1140

gaagagtacg atgtgctgga caagcggaga ggcagagatc ctgagatggg cggcaagccc     1200

agacggaaga atcctcaaga gggcctgtat aatgagctgc agaaagacaa gatggccgag     1260

gcctacagcg agatcggaat gaagggcgag cgcagaagag gcaagggaca cgatggactg     1320

tatcagggcc tgagcaccgc caccaaggat acctatgatg ccctgcacat gcaggccctg     1380

cctccaaga                                                             1389


<210>  35
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CSR 01 CD2.DH.z

<400>  35

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn Arg 
            340                 345                 350         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        355                 360                 365             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    370                 375                 380                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
385                 390                 395                 400 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                405                 410                 415     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            420                 425                 430         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        435                 440                 445             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460             


<210>  36
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CSR 01 CD2.DH.z

<400>  36
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagagat cacaaacgcc ctggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac cacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

agcctgctga tggtgtttgt ggctctgctg gtgttctaca tcaccaagcg gaagaagcag      720

cggagcagac ggaacgacga ggaactggaa acacgggccc atagagtggc caccgaggaa      780

agaggcagaa agccccacca gattccagcc agcacacccc agaatcctgc cacctctcaa      840

caccctccac ctccacctgg acacagatct caggccccat ctcacagacc tccaccacct      900

ggtcatcggg tgcagcacca gcctcagaaa agacctcctg ctcctagcgg cacacaggtg      960

caccagcaaa aaggacctcc actgcctcgg cctagagtgc agcctaaacc tcctcatggc     1020

gccgctgaga acagcctgtc tccaagcagc aacagagtga agttcagccg cagcgccgat     1080

gctcctgcct ataagcaggg acagaaccag ctgtacaacg agctgaatct ggggcgcaga     1140

gaagagtacg atgtgctgga caagcggaga ggcagagatc ctgagatggg cggcaagccc     1200

agacggaaga atcctcaaga gggcctgtat aatgagctgc agaaagacaa gatggccgag     1260

gcctacagcg agatcggaat gaagggcgag cgcagaagag gcaagggaca cgatggactg     1320

tatcagggcc tgagcaccgc caccaaggat acctatgatg ccctgcacat gcaggccctg     1380

cctccaaga                                                             1389


<210>  37
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.z polypeptide

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly 
            20                  25                  30          


Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser 
        35                  40                  45              


Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys 
    50                  55                  60                  


Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr 
65                  70                  75                  80  


Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr 
                85                  90                  95      


Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys 
            100                 105                 110         


Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser 
        115                 120                 125             


Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu 
    130                 135                 140                 


Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys 
145                 150                 155                 160 


His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser 
                165                 170                 175     


Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu 
            180                 185                 190         


Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr 
        195                 200                 205             


Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
    210                 215                 220                 


Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln Arg Ser Arg 
225                 230                 235                 240 


Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu 
                245                 250                 255     


Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn 
            260                 265                 270         


Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His Arg Ser Gln 
        275                 280                 285             


Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val Gln His Gln 
    290                 295                 300                 


Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln 
305                 310                 315                 320 


Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His 
                325                 330                 335     


Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn Arg Val Lys Phe 
            340                 345                 350         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
        355                 360                 365             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 


<210>  38
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.z polynucleotide sequence

<400>  38
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctaaagaaa tcacgaatgc attggaaacc tggggagccc tcggccagga tattaacctg      120

gacatcccca gcttccagat gagcgacgac atcgatgaca tcaagtggga gaaaaccagc      180

gacaagaaga agatcgccca gttccggaaa gagaaagaga cattcaaaga gaaggacacc      240

tacaagctgt tcaagaacgg caccctgaag atcaagcacc tgaaaaccga cgaccaggac      300

atctataagg tgtccatcta ccacaccaag ggcaagaacg tgctggaaaa gatcttcgac      360

ctcaagatcc aagagcgggt gtccaagcct aagatcagct ggacctgcat caacaccaca      420

ctgacctgcg aagtgatgaa cggcacagac cccgagctga acctgtacca ggatggcaaa      480

cacctgaagc tgagccagcg cgtgatcacc cacaagtgga caacaagcct gagcgccaag      540

ttcaagtgca ccgccggaaa caaagtgtct aaagagtcca gcgtcgagcc cgtgtcttgc      600

cctgaaaaag gactggacat ctacctgatc atcggcatct gtggcggcgg atccctgctg      660

atggtgtttg tggctctgct ggtgttctac atcaccaagc ggaagaagca gcggagcaga      720

cggaacgacg aggaactgga aacacgggcc catagagtgg ccaccgagga aagaggcaga      780

aagccccacc agattccagc cagcacaccc cagaatcctg ccacctctca acaccctcca      840

cctccacctg gacacagatc tcaggcccca tctcacagac ctccaccacc tggtcatcgg      900

gtgcagcacc agcctcagaa aagacctcct gctcctagcg gcacacaggt gcaccagcaa      960

aaaggacctc cactgcctcg gcctagagtg cagcctaaac ctcctcatgg cgccgctgag     1020

aacagcctgt ctccaagcag caacagagtg aaattcagcc gcagcgccga tgctcctgcc     1080

tataagcagg gacagaacca gctgtacaac gagctgaatc tggggcgcag agaagagtac     1140

gatgtgctgg acaagcggag aggcagagat cctgagatgg gcggcaagcc cagacggaag     1200

aatcctcaag agggcctgta taatgagctg cagaaagaca agatggccga ggcctacagc     1260

gagatcggaa tgaagggcga gcgcagaaga ggcaagggac acgatggact gtatcagggc     1320

ctgagcaccg ccaccaagga tacctatgat gccctgcaca tgcaggccct gcctccaaga     1380


<210>  39
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.DH.28.z polypeptide sequence

<400>  39

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Arg Ser Lys Arg Ser 
225                 230                 235                 240 


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
                245                 250                 255     


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
            260                 265                 270         


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        275                 280                 285             


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    290                 295                 300                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
305                 310                 315                 320 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                325                 330                 335     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            340                 345                 350         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        355                 360                 365             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    370                 375                 380                 


Leu Pro Pro Arg 
385             


<210>  40
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.DH.28.z polynudeotide sequence

<400>  40
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagaaat cacgaatgca ttggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac cacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

tccctgctga tggtgtttgt ggctctgctg gtgttctaca tcaccagaag caagcggagc      720

cggctgctgc acagcgacta catgaacatg acccctagac ggcccggacc taccagaaag      780

cactaccagc cttacgctcc tcctagagac ttcgccgcct accggtccag agtgaaattc      840

agccgcagcg ccgatgctcc tgcctataag cagggacaga accagctgta caacgagctg      900

aatctggggc gcagagaaga gtacgatgtg ctggacaagc ggagaggcag agatcctgag      960

atgggcggca agcccagacg gaagaatcct caagagggcc tgtataatga gctgcagaaa     1020

gacaagatgg ccgaggccta cagcgagatc ggaatgaagg gcgagcgcag aagaggcaag     1080

ggacacgatg gactgtatca gggcctgagc accgccacca aggataccta tgatgccctg     1140

cacatgcagg ccctgcctcc aaga                                            1164


<210>  41
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.28z polypeptide sequence

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly 
            20                  25                  30          


Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser 
        35                  40                  45              


Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys 
    50                  55                  60                  


Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr 
65                  70                  75                  80  


Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr 
                85                  90                  95      


Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys 
            100                 105                 110         


Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser 
        115                 120                 125             


Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu 
    130                 135                 140                 


Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys 
145                 150                 155                 160 


His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser 
                165                 170                 175     


Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu 
            180                 185                 190         


Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr 
        195                 200                 205             


Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
    210                 215                 220                 


Ala Leu Leu Val Phe Tyr Ile Thr Arg Ser Lys Arg Ser Arg Leu Leu 
225                 230                 235                 240 


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
                245                 250                 255     


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
            260                 265                 270         


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        275                 280                 285             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    290                 295                 300                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
305                 310                 315                 320 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                325                 330                 335     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            340                 345                 350         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        355                 360                 365             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    370                 375                 380                 


Arg 
385 


<210>  42
<211>  1155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.28z polynucleotide sequence

<400>  42
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctaaagaaa tcacgaatgc attggaaacc tggggagccc tcggccagga tattaacctg      120

gacatcccca gcttccagat gagcgacgac atcgatgaca tcaagtggga gaaaaccagc      180

gacaagaaga agatcgccca gttccggaaa gagaaagaga cattcaaaga gaaggacacc      240

tacaagctgt tcaagaacgg caccctgaag atcaagcacc tgaaaaccga cgaccaggac      300

atctataagg tgtccatcta ccacaccaag ggcaagaacg tgctggaaaa gatcttcgac      360

ctcaagatcc aagagcgggt gtccaagcct aagatcagct ggacctgcat caacaccaca      420

ctgacctgcg aagtgatgaa cggcacagac cccgagctga acctgtacca ggatggcaaa      480

cacctgaagc tgagccagcg cgtgatcacc cacaagtgga caacaagcct gagcgccaag      540

ttcaagtgca ccgccggaaa caaagtgtct aaagagtcca gcgtcgagcc cgtgtcttgc      600

cctgaaaaag gactggacat ctacctgatc atcggcatct gtggcggcgg atccctgctg      660

atggtgtttg tggctctgct ggtgttctac atcaccagaa gcaagcggag ccggctgctg      720

cacagcgact acatgaacat gacccctaga cggcccggac ctaccagaaa gcactaccag      780

ccttacgctc ctcctagaga cttcgccgcc taccggtcca gagtgaaatt cagccgcagc      840

gccgatgctc ctgcctataa gcagggacag aaccagctgt acaacgagct gaatctgggg      900

cgcagagaag agtacgatgt gctggacaag cggagaggca gagatcctga gatgggcggc      960

aagcccagac ggaagaatcc tcaagagggc ctgtataatg agctgcagaa agacaagatg     1020

gccgaggcct acagcgagat cggaatgaag ggcgagcgca gaagaggcaa gggacacgat     1080

ggactgtatc agggcctgag caccgccacc aaggatacct atgatgccct gcacatgcag     1140

gccctgcctc caaga                                                      1155


<210>  43
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.DH.BBz polypeptide sequence

<400>  43

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Gly Arg Lys 
225                 230                 235                 240 


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
                245                 250                 255     


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
            260                 265                 270         


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        275                 280                 285             


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    290                 295                 300                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
305                 310                 315                 320 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                325                 330                 335     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            340                 345                 350         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        355                 360                 365             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    370                 375                 380                 


Ala Leu Pro Pro Arg 
385                 


<210>  44
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.DH.BBz polynucleotide sequence

<400>  44
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagaaat cacgaatgca ttggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac cacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

tccctgctga tggtgtttgt ggctctgctg gtgttctaca tcaccaagcg gggcagaaag      720

aagctgctgt acatcttcaa gcagcccttc atgcggcccg tgcagaccac acaagaggaa      780

gatggctgct cctgcagatt ccccgaggaa gaagaaggcg gctgcgagct gagagtgaaa      840

ttcagccgca gcgccgatgc tcctgcctat aagcagggac agaaccagct gtacaacgag      900

ctgaatctgg ggcgcagaga agagtacgat gtgctggaca agcggagagg cagagatcct      960

gagatgggcg gcaagcccag acggaagaat cctcaagagg gcctgtataa tgagctgcag     1020

aaagacaaga tggccgaggc ctacagcgag atcggaatga agggcgagcg cagaagaggc     1080

aagggacacg atggactgta tcagggcctg agcaccgcca ccaaggatac ctatgatgcc     1140

ctgcacatgc aggccctgcc tccaaga                                         1167


<210>  45
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.BBz polypeptide sequence

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly 
            20                  25                  30          


Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser 
        35                  40                  45              


Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys 
    50                  55                  60                  


Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr 
65                  70                  75                  80  


Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr 
                85                  90                  95      


Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys 
            100                 105                 110         


Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser 
        115                 120                 125             


Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu 
    130                 135                 140                 


Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys 
145                 150                 155                 160 


His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser 
                165                 170                 175     


Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu 
            180                 185                 190         


Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr 
        195                 200                 205             


Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
    210                 215                 220                 


Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Gly Arg Lys Lys Leu Leu 
225                 230                 235                 240 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                245                 250                 255     


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            260                 265                 270         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        275                 280                 285             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    290                 295                 300                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
305                 310                 315                 320 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                325                 330                 335     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            340                 345                 350         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        355                 360                 365             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    370                 375                 380                 


Pro Arg 
385     


<210>  46
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.BBz polynucleotide sequence

<400>  46
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctaaagaaa tcacgaatgc attggaaacc tggggagccc tcggccagga tattaacctg      120

gacatcccca gcttccagat gagcgacgac atcgatgaca tcaagtggga gaaaaccagc      180

gacaagaaga agatcgccca gttccggaaa gagaaagaga cattcaaaga gaaggacacc      240

tacaagctgt tcaagaacgg caccctgaag atcaagcacc tgaaaaccga cgaccaggac      300

atctataagg tgtccatcta ccacaccaag ggcaagaacg tgctggaaaa gatcttcgac      360

ctcaagatcc aagagcgggt gtccaagcct aagatcagct ggacctgcat caacaccaca      420

ctgacctgcg aagtgatgaa cggcacagac cccgagctga acctgtacca ggatggcaaa      480

cacctgaagc tgagccagcg cgtgatcacc cacaagtgga caacaagcct gagcgccaag      540

ttcaagtgca ccgccggaaa caaagtgtct aaagagtcca gcgtcgagcc cgtgtcttgc      600

cctgaaaaag gactggacat ctacctgatc atcggcatct gtggcggcgg atccctgctg      660

atggtgtttg tggctctgct ggtgttctac atcaccaagc ggggcagaaa gaagctgctg      720

tacatcttca agcagccctt catgcggccc gtgcagacca cacaagagga agatggctgc      780

tcctgcagat tccccgagga agaagaaggc ggctgcgagc tgagagtgaa attcagccgc      840

agcgccgatg ctcctgccta taagcaggga cagaaccagc tgtacaacga gctgaatctg      900

gggcgcagag aagagtacga tgtgctggac aagcggagag gcagagatcc tgagatgggc      960

ggcaagccca gacggaagaa tcctcaagag ggcctgtata atgagctgca gaaagacaag     1020

atggccgagg cctacagcga gatcggaatg aagggcgagc gcagaagagg caagggacac     1080

gatggactgt atcagggcct gagcaccgcc accaaggata cctatgatgc cctgcacatg     1140

caggccctgc ctccaaga                                                   1158


<210>  47
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.DH.7z polypeptide sequence

<400>  47

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Lys Arg Ile Lys 
225                 230                 235                 240 


Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His 
                245                 250                 255     


Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu 
            260                 265                 270         


Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg 
        275                 280                 285             


Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu 
    290                 295                 300                 


Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys 
305                 310                 315                 320 


Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser 
                325                 330                 335     


Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile 
            340                 345                 350         


Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly 
        355                 360                 365             


Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser 
    370                 375                 380                 


Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn 
385                 390                 395                 400 


Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln 
                405                 410                 415     


Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Arg Val 
            420                 425                 430         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        435                 440                 445             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    450                 455                 460                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
465                 470                 475                 480 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                485                 490                 495     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            500                 505                 510         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        515                 520                 525             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540         


<210>  48
<211>  1626
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.DH.7z polynucleotide sequence

<400>  48
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagaaat cacgaatgca ttggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac cacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

tccctgctga tggtgtttgt ggctctgctg gtgttctaca tcaccaagaa gcggatcaag      720

cccatcgtgt ggcccagcct gcctgaccac aagaaaaccc tggaacacct gtgcaagaag      780

ccccggaaga acctgaatgt gtccttcaat cccgagagct tcctggactg ccagatccac      840

agagtggacg acatccaggc cagagatgag gtggaaggct ttctgcagga cacctttcca      900

cagcagctgg aagagagcga gaagcagaga ctcggcggag atgtgcagag ccctaattgc      960

cctagcgagg acgtggtcat cacccctgag agcttcggca gagatagcag cctgacatgt     1020

ctggccggca atgtgtccgc ctgtgatgcc cctatcctga gcagcagcag aagcctggat     1080

tgcagagaga gcggaaagaa cggccctcat gtgtatcagg acctgctgct gagcctgggc     1140

accaccaatt ctacactgcc tccaccattc agcctgcaga gcggcatcct gacactgaac     1200

cctgttgctc agggccagcc aatcctgaca agcctgggct ccaatcaaga agaggcctac     1260

gtcaccatgt ccagcttcta ccagaaccag agagtgaaat tcagccgcag cgccgatgct     1320

cctgcctata agcagggaca gaaccagctg tacaacgagc tgaatctggg gcgcagagaa     1380

gagtacgatg tgctggacaa gcggagaggc agagatcctg agatgggcgg caagcccaga     1440

cggaagaatc ctcaagaggg cctgtataat gagctgcaga aagacaagat ggccgaggcc     1500

tacagcgaga tcggaatgaa gggcgagcgc agaagaggca agggacacga tggactgtat     1560

cagggcctga gcaccgccac caaggatacc tatgatgccc tgcacatgca ggccctgcct     1620

ccaaga                                                                1626


<210>  49
<211>  539
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.7z polypeptide sequence

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly 
            20                  25                  30          


Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser 
        35                  40                  45              


Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys 
    50                  55                  60                  


Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr 
65                  70                  75                  80  


Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr 
                85                  90                  95      


Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys 
            100                 105                 110         


Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser 
        115                 120                 125             


Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu 
    130                 135                 140                 


Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys 
145                 150                 155                 160 


His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser 
                165                 170                 175     


Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu 
            180                 185                 190         


Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr 
        195                 200                 205             


Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
    210                 215                 220                 


Ala Leu Leu Val Phe Tyr Ile Thr Lys Lys Arg Ile Lys Pro Ile Val 
225                 230                 235                 240 


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
                245                 250                 255     


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
            260                 265                 270         


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
        275                 280                 285             


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
    290                 295                 300                 


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
305                 310                 315                 320 


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
                325                 330                 335     


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
            340                 345                 350         


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
        355                 360                 365             


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
    370                 375                 380                 


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
385                 390                 395                 400 


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
                405                 410                 415     


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln Arg Val Lys Phe Ser 
            420                 425                 430         


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
        435                 440                 445             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    450                 455                 460                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
465                 470                 475                 480 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                485                 490                 495     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            500                 505                 510         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        515                 520                 525             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 


<210>  50
<211>  1617
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.7z polynucleotide sequence

<400>  50
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctaaagaaa tcacgaatgc attggaaacc tggggagccc tcggccagga tattaacctg      120

gacatcccca gcttccagat gagcgacgac atcgatgaca tcaagtggga gaaaaccagc      180

gacaagaaga agatcgccca gttccggaaa gagaaagaga cattcaaaga gaaggacacc      240

tacaagctgt tcaagaacgg caccctgaag atcaagcacc tgaaaaccga cgaccaggac      300

atctataagg tgtccatcta ccacaccaag ggcaagaacg tgctggaaaa gatcttcgac      360

ctcaagatcc aagagcgggt gtccaagcct aagatcagct ggacctgcat caacaccaca      420

ctgacctgcg aagtgatgaa cggcacagac cccgagctga acctgtacca ggatggcaaa      480

cacctgaagc tgagccagcg cgtgatcacc cacaagtgga caacaagcct gagcgccaag      540

ttcaagtgca ccgccggaaa caaagtgtct aaagagtcca gcgtcgagcc cgtgtcttgc      600

cctgaaaaag gactggacat ctacctgatc atcggcatct gtggcggcgg atccctgctg      660

atggtgtttg tggctctgct ggtgttctac atcaccaaga agcggatcaa gcccatcgtg      720

tggcccagcc tgcctgacca caagaaaacc ctggaacacc tgtgcaagaa gccccggaag      780

aacctgaatg tgtccttcaa tcccgagagc ttcctggact gccagatcca cagagtggac      840

gacatccagg ccagagatga ggtggaaggc tttctgcagg acacctttcc acagcagctg      900

gaagagagcg agaagcagag actcggcgga gatgtgcaga gccctaattg ccctagcgag      960

gacgtggtca tcacccctga gagcttcggc agagatagca gcctgacatg tctggccggc     1020

aatgtgtccg cctgtgatgc ccctatcctg agcagcagca gaagcctgga ttgcagagag     1080

agcggaaaga acggccctca tgtgtatcag gacctgctgc tgagcctggg caccaccaat     1140

tctacactgc ctccaccatt cagcctgcag agcggcatcc tgacactgaa ccctgttgct     1200

cagggccagc caatcctgac aagcctgggc tccaatcaag aagaggccta cgtcaccatg     1260

tccagcttct accagaacca gagagtgaaa ttcagccgca gcgccgatgc tcctgcctat     1320

aagcagggac agaaccagct gtacaacgag ctgaatctgg ggcgcagaga agagtacgat     1380

gtgctggaca agcggagagg cagagatcct gagatgggcg gcaagcccag acggaagaat     1440

cctcaagagg gcctgtataa tgagctgcag aaagacaaga tggccgaggc ctacagcgag     1500

atcggaatga agggcgagcg cagaagaggc aagggacacg atggactgta tcagggcctg     1560

agcaccgcca ccaaggatac ctatgatgcc ctgcacatgc aggccctgcc tccaaga        1617


<210>  51
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.DH.15z polypeptide sequence

<400>  51

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Ser Arg Gln Thr 
225                 230                 235                 240 


Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro Val 
                245                 250                 255     


Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His 
            260                 265                 270         


His Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        275                 280                 285             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    290                 295                 300                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
305                 310                 315                 320 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                325                 330                 335     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            340                 345                 350         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        355                 360                 365             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    370                 375                 380                 


Pro Arg 
385     


<210>  52
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.DH.15z polynucleotide sequence

<400>  52
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagaaat cacgaatgca ttggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac cacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

tccctgctga tggtgtttgt ggctctgctg gtgttctaca tcaccaagag ccggcagaca      720

cctcctctgg ccagcgtgga aatggaagcc atggaagctc tgcctgtgac ctggggcaca      780

agcagcagag atgaggacct ggaaaactgc agccaccacc tgagagtgaa attcagccgc      840

agcgccgatg ctcctgccta taagcaggga cagaaccagc tgtacaacga gctgaatctg      900

gggcgcagag aagagtacga tgtgctggac aagcggagag gcagagatcc tgagatgggc      960

ggcaagccca gacggaagaa tcctcaagag ggcctgtata atgagctgca gaaagacaag     1020

atggccgagg cctacagcga gatcggaatg aagggcgagc gcagaagagg caagggacac     1080

gatggactgt atcagggcct gagcaccgcc accaaggata cctatgatgc cctgcacatg     1140

caggccctgc ctccaaga                                                   1158


<210>  53
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.15z polypeptide sequence

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly 
            20                  25                  30          


Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser 
        35                  40                  45              


Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys 
    50                  55                  60                  


Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr 
65                  70                  75                  80  


Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr 
                85                  90                  95      


Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys 
            100                 105                 110         


Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser 
        115                 120                 125             


Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu 
    130                 135                 140                 


Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys 
145                 150                 155                 160 


His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser 
                165                 170                 175     


Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu 
            180                 185                 190         


Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr 
        195                 200                 205             


Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
    210                 215                 220                 


Ala Leu Leu Val Phe Tyr Ile Thr Lys Ser Arg Gln Thr Pro Pro Leu 
225                 230                 235                 240 


Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly 
                245                 250                 255     


Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Arg 
            260                 265                 270         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        275                 280                 285             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    290                 295                 300                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
305                 310                 315                 320 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                325                 330                 335     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            340                 345                 350         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        355                 360                 365             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 380             


<210>  54
<211>  1149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.15z polynucleotide sequence

<400>  54
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctaaagaaa tcacgaatgc attggaaacc tggggagccc tcggccagga tattaacctg      120

gacatcccca gcttccagat gagcgacgac atcgatgaca tcaagtggga gaaaaccagc      180

gacaagaaga agatcgccca gttccggaaa gagaaagaga cattcaaaga gaaggacacc      240

tacaagctgt tcaagaacgg caccctgaag atcaagcacc tgaaaaccga cgaccaggac      300

atctataagg tgtccatcta ccacaccaag ggcaagaacg tgctggaaaa gatcttcgac      360

ctcaagatcc aagagcgggt gtccaagcct aagatcagct ggacctgcat caacaccaca      420

ctgacctgcg aagtgatgaa cggcacagac cccgagctga acctgtacca ggatggcaaa      480

cacctgaagc tgagccagcg cgtgatcacc cacaagtgga caacaagcct gagcgccaag      540

ttcaagtgca ccgccggaaa caaagtgtct aaagagtcca gcgtcgagcc cgtgtcttgc      600

cctgaaaaag gactggacat ctacctgatc atcggcatct gtggcggcgg atccctgctg      660

atggtgtttg tggctctgct ggtgttctac atcaccaaga gccggcagac acctcctctg      720

gccagcgtgg aaatggaagc catggaagct ctgcctgtga cctggggcac aagcagcaga      780

gatgaggacc tggaaaactg cagccaccac ctgagagtga aattcagccg cagcgccgat      840

gctcctgcct ataagcaggg acagaaccag ctgtacaacg agctgaatct ggggcgcaga      900

gaagagtacg atgtgctgga caagcggaga ggcagagatc ctgagatggg cggcaagccc      960

agacggaaga atcctcaaga gggcctgtat aatgagctgc agaaagacaa gatggccgag     1020

gcctacagcg agatcggaat gaagggcgag cgcagaagag gcaagggaca cgatggactg     1080

tatcagggcc tgagcaccgc caccaaggat acctatgatg ccctgcacat gcaggccctg     1140

cctccaaga                                                             1149


<210>  55
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.DH.21z polypeptide sequence

<400>  55

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Ser Leu Lys Thr His 
225                 230                 235                 240 


Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser Pro Glu 
                245                 250                 255     


Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe Lys Lys 
            260                 265                 270         


Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly Pro Trp 
        275                 280                 285             


Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His Pro Pro 
    290                 295                 300                 


Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala 
305                 310                 315                 320 


Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp Pro Thr 
                325                 330                 335     


Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro 
            340                 345                 350         


Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly 
        355                 360                 365             


Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu 
    370                 375                 380                 


Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu 
385                 390                 395                 400 


Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly 
                405                 410                 415     


Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys 
            420                 425                 430         


Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly 
        435                 440                 445             


Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu 
    450                 455                 460                 


Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp 
465                 470                 475                 480 


Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly 
                485                 490                 495     


Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu 
            500                 505                 510         


Ser Ser Pro Gly Pro Gln Ala Ser Arg Val Lys Phe Ser Arg Ser Ala 
        515                 520                 525             


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    530                 535                 540                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
545                 550                 555                 560 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                565                 570                 575     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            580                 585                 590         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        595                 600                 605             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    610                 615                 620                 


His Met Gln Ala Leu Pro Pro Arg 
625                 630         


<210>  56
<211>  1896
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.DH.21z polynucleotide sequence

<400>  56
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagaaat cacgaatgca ttggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac cacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

tccctgctga tggtgtttgt ggctctgctg gtgttctaca tcaccagcct gaaaacacac      720

ccactctggc ggctgtggaa gaaaatctgg gccgtgccat ctcctgagcg gttcttcatg      780

cctctgtaca agggctgcag cggcgacttc aagaaatggg tcggagcccc ttttaccggc      840

agctctctgg aacttggacc ttggagccct gaggtgccca gcacactgga agtgtacagc      900

tgtcaccctc ctagaagccc cgccaagaga ctgcagctga cagagctgca agagcctgcc      960

gagctggtgg aatctgatgg cgtgcccaag cctagcttct ggcccacagc tcagaatagc     1020

ggcggctctg cctacagcga ggaaagggat agaccttacg gcctggtgtc tatcgacacc     1080

gtgaccgtgc tggatgccga gggaccttgt acatggcctt gcagctgcga ggacgatggc     1140

taccctgctc tggatctgga cgcaggcctt gagccttctc caggactgga agatcctctg     1200

ctggacgccg gaacaaccgt gctgtcttgt ggctgtgtgt ctgccggatc tcctggactt     1260

ggaggccctc tgggaagcct gctggataga ctgaaacctc ctctggccga cggcgaagat     1320

tgggctggtg gacttccttg gggcggaaga tctccaggcg gagtgtctga gtctgaagcc     1380

ggttctccac tggccggcct ggacatggat accttcgatt ctggcttcgt gggcagcgac     1440

tgtagcagcc ctgtggaatg cgacttcaca agccctggcg acgagggccc acctagaagc     1500

tatctgagac agtgggtcgt gatccctcca cctctgtcta gtcctggacc tcaggccagc     1560

agagtgaaat tcagccgcag cgccgatgct cctgcctata agcagggaca gaaccagctg     1620

tacaacgagc tgaatctggg gcgcagagaa gagtacgatg tgctggacaa gcggagaggc     1680

agagatcctg agatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtataat     1740

gagctgcaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgagcgc     1800

agaagaggca agggacacga tggactgtat cagggcctga gcaccgccac caaggatacc     1860

tatgatgccc tgcacatgca ggccctgcct ccaaga                               1896


<210>  57
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.21z polypeptide sequence

<400>  57

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly 
            20                  25                  30          


Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser 
        35                  40                  45              


Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys 
    50                  55                  60                  


Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr 
65                  70                  75                  80  


Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr 
                85                  90                  95      


Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys 
            100                 105                 110         


Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser 
        115                 120                 125             


Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu 
    130                 135                 140                 


Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys 
145                 150                 155                 160 


His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser 
                165                 170                 175     


Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu 
            180                 185                 190         


Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr 
        195                 200                 205             


Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
    210                 215                 220                 


Ala Leu Leu Val Phe Tyr Ile Thr Ser Leu Lys Thr His Pro Leu Trp 
225                 230                 235                 240 


Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser Pro Glu Arg Phe Phe 
                245                 250                 255     


Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe Lys Lys Trp Val Gly 
            260                 265                 270         


Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly Pro Trp Ser Pro Glu 
        275                 280                 285             


Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His Pro Pro Arg Ser Pro 
    290                 295                 300                 


Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu Pro Ala Glu Leu Val 
305                 310                 315                 320 


Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn 
                325                 330                 335     


Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu 
            340                 345                 350         


Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro Cys Thr 
        355                 360                 365             


Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp 
    370                 375                 380                 


Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala 
385                 390                 395                 400 


Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser Pro Gly 
                405                 410                 415     


Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu 
            420                 425                 430         


Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser 
        435                 440                 445             


Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu 
    450                 455                 460                 


Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys Ser Ser 
465                 470                 475                 480 


Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg 
                485                 490                 495     


Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser Ser Pro 
            500                 505                 510         


Gly Pro Gln Ala Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        515                 520                 525             


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    530                 535                 540                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
545                 550                 555                 560 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                565                 570                 575     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            580                 585                 590         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        595                 600                 605             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    610                 615                 620                 


Ala Leu Pro Pro Arg 
625                 


<210>  58
<211>  1887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.21z polynucleotide sequence

<400>  58
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctaaagaaa tcacgaatgc attggaaacc tggggagccc tcggccagga tattaacctg      120

gacatcccca gcttccagat gagcgacgac atcgatgaca tcaagtggga gaaaaccagc      180

gacaagaaga agatcgccca gttccggaaa gagaaagaga cattcaaaga gaaggacacc      240

tacaagctgt tcaagaacgg caccctgaag atcaagcacc tgaaaaccga cgaccaggac      300

atctataagg tgtccatcta ccacaccaag ggcaagaacg tgctggaaaa gatcttcgac      360

ctcaagatcc aagagcgggt gtccaagcct aagatcagct ggacctgcat caacaccaca      420

ctgacctgcg aagtgatgaa cggcacagac cccgagctga acctgtacca ggatggcaaa      480

cacctgaagc tgagccagcg cgtgatcacc cacaagtgga caacaagcct gagcgccaag      540

ttcaagtgca ccgccggaaa caaagtgtct aaagagtcca gcgtcgagcc cgtgtcttgc      600

cctgaaaaag gactggacat ctacctgatc atcggcatct gtggcggcgg atccctgctg      660

atggtgtttg tggctctgct ggtgttctac atcaccagcc tgaaaacaca cccactctgg      720

cggctgtgga agaaaatctg ggccgtgcca tctcctgagc ggttcttcat gcctctgtac      780

aagggctgca gcggcgactt caagaaatgg gtcggagccc cttttaccgg cagctctctg      840

gaacttggac cttggagccc tgaggtgccc agcacactgg aagtgtacag ctgtcaccct      900

cctagaagcc ccgccaagag actgcagctg acagagctgc aagagcctgc cgagctggtg      960

gaatctgatg gcgtgcccaa gcctagcttc tggcccacag ctcagaatag cggcggctct     1020

gcctacagcg aggaaaggga tagaccttac ggcctggtgt ctatcgacac cgtgaccgtg     1080

ctggatgccg agggaccttg tacatggcct tgcagctgcg aggacgatgg ctaccctgct     1140

ctggatctgg acgcaggcct tgagccttct ccaggactgg aagatcctct gctggacgcc     1200

ggaacaaccg tgctgtcttg tggctgtgtg tctgccggat ctcctggact tggaggccct     1260

ctgggaagcc tgctggatag actgaaacct cctctggccg acggcgaaga ttgggctggt     1320

ggacttcctt ggggcggaag atctccaggc ggagtgtctg agtctgaagc cggttctcca     1380

ctggccggcc tggacatgga taccttcgat tctggcttcg tgggcagcga ctgtagcagc     1440

cctgtggaat gcgacttcac aagccctggc gacgagggcc cacctagaag ctatctgaga     1500

cagtgggtcg tgatccctcc acctctgtct agtcctggac ctcaggccag cagagtgaaa     1560

ttcagccgca gcgccgatgc tcctgcctat aagcagggac agaaccagct gtacaacgag     1620

ctgaatctgg ggcgcagaga agagtacgat gtgctggaca agcggagagg cagagatcct     1680

gagatgggcg gcaagcccag acggaagaat cctcaagagg gcctgtataa tgagctgcag     1740

aaagacaaga tggccgaggc ctacagcgag atcggaatga agggcgagcg cagaagaggc     1800

aagggacacg atggactgta tcagggcctg agcaccgcca ccaaggatac ctatgatgcc     1860

ctgcacatgc aggccctgcc tccaaga                                         1887


<210>  59
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.DH.Iz polypeptide sequence

<400>  59

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Cys Trp Leu Thr Lys 
225                 230                 235                 240 


Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe 
                245                 250                 255     


Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr 
            260                 265                 270         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        275                 280                 285             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    290                 295                 300                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
305                 310                 315                 320 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                325                 330                 335     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            340                 345                 350         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        355                 360                 365             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    370                 375                 380                 


Arg 
385 


<210>  60
<211>  1155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.DH.Iz polynucleotide sequence

<400>  60
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagaaat cacgaatgca ttggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac cacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

tccctgctga tggtgtttgt ggctctgctg gtgttctaca tcacctgttg gctgaccaag      720

aaaaagtaca gcagcagcgt gcacgacccc aacggcgagt acatgttcat gagagccgtg      780

aacaccgcca agaagtccag actgaccgac gtgaccctga gagtgaaatt cagccgcagc      840

gccgatgctc ctgcctataa gcagggacag aaccagctgt acaacgagct gaatctgggg      900

cgcagagaag agtacgatgt gctggacaag cggagaggca gagatcctga gatgggcggc      960

aagcccagac ggaagaatcc tcaagagggc ctgtataatg agctgcagaa agacaagatg     1020

gccgaggcct acagcgagat cggaatgaag ggcgagcgca gaagaggcaa gggacacgat     1080

ggactgtatc agggcctgag caccgccacc aaggatacct atgatgccct gcacatgcag     1140

gccctgcctc caaga                                                      1155


<210>  61
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.Iz polypeptide sequence

<400>  61

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly 
            20                  25                  30          


Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser 
        35                  40                  45              


Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys 
    50                  55                  60                  


Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr 
65                  70                  75                  80  


Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr 
                85                  90                  95      


Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys 
            100                 105                 110         


Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser 
        115                 120                 125             


Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu 
    130                 135                 140                 


Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys 
145                 150                 155                 160 


His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser 
                165                 170                 175     


Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu 
            180                 185                 190         


Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr 
        195                 200                 205             


Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
    210                 215                 220                 


Ala Leu Leu Val Phe Tyr Ile Thr Cys Trp Leu Thr Lys Lys Lys Tyr 
225                 230                 235                 240 


Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala 
                245                 250                 255     


Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Arg Val 
            260                 265                 270         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        275                 280                 285             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    290                 295                 300                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
305                 310                 315                 320 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                325                 330                 335     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            340                 345                 350         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        355                 360                 365             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 380         


<210>  62
<211>  1146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.Iz polynucleotide sequence

<400>  62
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctaaagaaa tcacgaatgc attggaaacc tggggagccc tcggccagga tattaacctg      120

gacatcccca gcttccagat gagcgacgac atcgatgaca tcaagtggga gaaaaccagc      180

gacaagaaga agatcgccca gttccggaaa gagaaagaga cattcaaaga gaaggacacc      240

tacaagctgt tcaagaacgg caccctgaag atcaagcacc tgaaaaccga cgaccaggac      300

atctataagg tgtccatcta ccacaccaag ggcaagaacg tgctggaaaa gatcttcgac      360

ctcaagatcc aagagcgggt gtccaagcct aagatcagct ggacctgcat caacaccaca      420

ctgacctgcg aagtgatgaa cggcacagac cccgagctga acctgtacca ggatggcaaa      480

cacctgaagc tgagccagcg cgtgatcacc cacaagtgga caacaagcct gagcgccaag      540

ttcaagtgca ccgccggaaa caaagtgtct aaagagtcca gcgtcgagcc cgtgtcttgc      600

cctgaaaaag gactggacat ctacctgatc atcggcatct gtggcggcgg atccctgctg      660

atggtgtttg tggctctgct ggtgttctac atcacctgtt ggctgaccaa gaaaaagtac      720

agcagcagcg tgcacgaccc caacggcgag tacatgttca tgagagccgt gaacaccgcc      780

aagaagtcca gactgaccga cgtgaccctg agagtgaaat tcagccgcag cgccgatgct      840

cctgcctata agcagggaca gaaccagctg tacaacgagc tgaatctggg gcgcagagaa      900

gagtacgatg tgctggacaa gcggagaggc agagatcctg agatgggcgg caagcccaga      960

cggaagaatc ctcaagaggg cctgtataat gagctgcaga aagacaagat ggccgaggcc     1020

tacagcgaga tcggaatgaa gggcgagcgc agaagaggca agggacacga tggactgtat     1080

cagggcctga gcaccgccac caaggatacc tatgatgccc tgcacatgca ggccctgcct     1140

ccaaga                                                                1146


<210>  63
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.DH.27z polypeptide sequence

<400>  63

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Gln Arg Arg Lys Tyr 
225                 230                 235                 240 


Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys His 
                245                 250                 255     


Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu 
            260                 265                 270         


Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro Arg Val Lys Phe Ser 
        275                 280                 285             


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
    290                 295                 300                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
305                 310                 315                 320 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                325                 330                 335     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            340                 345                 350         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        355                 360                 365             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    370                 375                 380                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 395 


<210>  64
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.DH.27z polynucleotide sequence

<400>  64
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagaaat cacgaatgca ttggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac cacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

tccctgctga tggtgtttgt ggctctgctg gtgttctaca tcacccagcg gcggaagtac      720

agaagcaaca agggcgagag ccccgtggaa cctgccgagc cttgtcacta cagctgcccc      780

agagaggaag agggcagcac aatccccatc caagaggact acagaaagcc cgagcctgcc      840

tgctctccca gagtgaaatt cagccgcagc gccgatgctc ctgcctataa gcagggacag      900

aaccagctgt acaacgagct gaatctgggg cgcagagaag agtacgatgt gctggacaag      960

cggagaggca gagatcctga gatgggcggc aagcccagac ggaagaatcc tcaagagggc     1020

ctgtataatg agctgcagaa agacaagatg gccgaggcct acagcgagat cggaatgaag     1080

ggcgagcgca gaagaggcaa gggacacgat ggactgtatc agggcctgag caccgccacc     1140

aaggatacct atgatgccct gcacatgcag gccctgcctc caaga                     1185


<210>  65
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.27z polypeptide sequence

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly 
            20                  25                  30          


Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser 
        35                  40                  45              


Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys 
    50                  55                  60                  


Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr 
65                  70                  75                  80  


Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr 
                85                  90                  95      


Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys 
            100                 105                 110         


Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser 
        115                 120                 125             


Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu 
    130                 135                 140                 


Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys 
145                 150                 155                 160 


His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser 
                165                 170                 175     


Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu 
            180                 185                 190         


Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr 
        195                 200                 205             


Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
    210                 215                 220                 


Ala Leu Leu Val Phe Tyr Ile Thr Gln Arg Arg Lys Tyr Arg Ser Asn 
225                 230                 235                 240 


Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys 
                245                 250                 255     


Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg 
            260                 265                 270         


Lys Pro Glu Pro Ala Cys Ser Pro Arg Val Lys Phe Ser Arg Ser Ala 
        275                 280                 285             


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    290                 295                 300                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
305                 310                 315                 320 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                325                 330                 335     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            340                 345                 350         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        355                 360                 365             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    370                 375                 380                 


His Met Gln Ala Leu Pro Pro Arg 
385                 390         


<210>  66
<211>  1176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.27z polynucleotide sequence

<400>  66
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctaaagaaa tcacgaatgc attggaaacc tggggagccc tcggccagga tattaacctg      120

gacatcccca gcttccagat gagcgacgac atcgatgaca tcaagtggga gaaaaccagc      180

gacaagaaga agatcgccca gttccggaaa gagaaagaga cattcaaaga gaaggacacc      240

tacaagctgt tcaagaacgg caccctgaag atcaagcacc tgaaaaccga cgaccaggac      300

atctataagg tgtccatcta ccacaccaag ggcaagaacg tgctggaaaa gatcttcgac      360

ctcaagatcc aagagcgggt gtccaagcct aagatcagct ggacctgcat caacaccaca      420

ctgacctgcg aagtgatgaa cggcacagac cccgagctga acctgtacca ggatggcaaa      480

cacctgaagc tgagccagcg cgtgatcacc cacaagtgga caacaagcct gagcgccaag      540

ttcaagtgca ccgccggaaa caaagtgtct aaagagtcca gcgtcgagcc cgtgtcttgc      600

cctgaaaaag gactggacat ctacctgatc atcggcatct gtggcggcgg atccctgctg      660

atggtgtttg tggctctgct ggtgttctac atcacccagc ggcggaagta cagaagcaac      720

aagggcgaga gccccgtgga acctgccgag ccttgtcact acagctgccc cagagaggaa      780

gagggcagca caatccccat ccaagaggac tacagaaagc ccgagcctgc ctgctctccc      840

agagtgaaat tcagccgcag cgccgatgct cctgcctata agcagggaca gaaccagctg      900

tacaacgagc tgaatctggg gcgcagagaa gagtacgatg tgctggacaa gcggagaggc      960

agagatcctg agatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtataat     1020

gagctgcaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgagcgc     1080

agaagaggca agggacacga tggactgtat cagggcctga gcaccgccac caaggatacc     1140

tatgatgccc tgcacatgca ggccctgcct ccaaga                               1176


<210>  67
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.DH.Oxz polypeptide sequence

<400>  67

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        275                 280                 285             


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    290                 295                 300                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
305                 310                 315                 320 


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                325                 330                 335     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            340                 345                 350         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        355                 360                 365             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    370                 375                 380                 


Ala Leu Pro Pro Arg 
385                 


<210>  68
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.DH.Oxz polynucleotide sequence

<400>  68
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagaaat cacgaatgca ttggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac cacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

tccctgctga tggtgtttgt ggctctgctg gtgttctaca tcaccgccct gtacctgctg      720

cggcgggatc aaagattgcc tcctgacgct cacaagcctc caggcggagg cagctttaga      780

acccctatcc aagaggaaca ggctgacgcc cacagcaccc tggccaagat cagagtgaaa      840

ttcagccgca gcgccgatgc tcctgcctat aagcagggac agaaccagct gtacaacgag      900

ctgaatctgg ggcgcagaga agagtacgat gtgctggaca agcggagagg cagagatcct      960

gagatgggcg gcaagcccag acggaagaat cctcaagagg gcctgtataa tgagctgcag     1020

aaagacaaga tggccgaggc ctacagcgag atcggaatga agggcgagcg cagaagaggc     1080

aagggacacg atggactgta tcagggcctg agcaccgcca ccaaggatac ctatgatgcc     1140

ctgcacatgc aggccctgcc tccaaga                                         1167


<210>  69
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.Oxz polypeptide sequence

<400>  69

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly 
            20                  25                  30          


Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser 
        35                  40                  45              


Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys 
    50                  55                  60                  


Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr 
65                  70                  75                  80  


Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr 
                85                  90                  95      


Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys 
            100                 105                 110         


Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser 
        115                 120                 125             


Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu 
    130                 135                 140                 


Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys 
145                 150                 155                 160 


His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser 
                165                 170                 175     


Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu 
            180                 185                 190         


Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr 
        195                 200                 205             


Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
    210                 215                 220                 


Ala Leu Leu Val Phe Tyr Ile Thr Ala Leu Tyr Leu Leu Arg Arg Asp 
225                 230                 235                 240 


Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe 
                245                 250                 255     


Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala 
            260                 265                 270         


Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        275                 280                 285             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    290                 295                 300                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
305                 310                 315                 320 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                325                 330                 335     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            340                 345                 350         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        355                 360                 365             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    370                 375                 380                 


Pro Arg 
385     


<210>  70
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.Oxz polynucleotide sequence

<400>  70
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctaaagaaa tcacgaatgc attggaaacc tggggagccc tcggccagga tattaacctg      120

gacatcccca gcttccagat gagcgacgac atcgatgaca tcaagtggga gaaaaccagc      180

gacaagaaga agatcgccca gttccggaaa gagaaagaga cattcaaaga gaaggacacc      240

tacaagctgt tcaagaacgg caccctgaag atcaagcacc tgaaaaccga cgaccaggac      300

atctataagg tgtccatcta ccacaccaag ggcaagaacg tgctggaaaa gatcttcgac      360

ctcaagatcc aagagcgggt gtccaagcct aagatcagct ggacctgcat caacaccaca      420

ctgacctgcg aagtgatgaa cggcacagac cccgagctga acctgtacca ggatggcaaa      480

cacctgaagc tgagccagcg cgtgatcacc cacaagtgga caacaagcct gagcgccaag      540

ttcaagtgca ccgccggaaa caaagtgtct aaagagtcca gcgtcgagcc cgtgtcttgc      600

cctgaaaaag gactggacat ctacctgatc atcggcatct gtggcggcgg atccctgctg      660

atggtgtttg tggctctgct ggtgttctac atcaccgccc tgtacctgct gcggcgggat      720

caaagattgc ctcctgacgc tcacaagcct ccaggcggag gcagctttag aacccctatc      780

caagaggaac aggctgacgc ccacagcacc ctggccaaga tcagagtgaa attcagccgc      840

agcgccgatg ctcctgccta taagcaggga cagaaccagc tgtacaacga gctgaatctg      900

gggcgcagag aagagtacga tgtgctggac aagcggagag gcagagatcc tgagatgggc      960

ggcaagccca gacggaagaa tcctcaagag ggcctgtata atgagctgca gaaagacaag     1020

atggccgagg cctacagcga gatcggaatg aagggcgagc gcagaagagg caagggacac     1080

gatggactgt atcagggcct gagcaccgcc accaaggata cctatgatgc cctgcacatg     1140

caggccctgc ctccaaga                                                   1158


<210>  71
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.DH.Gz polypeptide sequence

<400>  71

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Gln Leu Gly Leu His 
225                 230                 235                 240 


Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu 
                245                 250                 255     


Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe 
            260                 265                 270         


Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu 
        275                 280                 285             


Gly Asp Leu Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    290                 295                 300                 


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
305                 310                 315                 320 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                325                 330                 335     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            340                 345                 350         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        355                 360                 365             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    370                 375                 380                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
385                 390                 395                 400 


Ala Leu Pro Pro Arg 
                405 


<210>  72
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.DH.Gz polynucleotide sequence

<400>  72
atgagcttcc cttgcaagtt cgtggccagc ttcctgctga tcttcaacgt gtcctctaag       60

ggcgccgtgt ccaaagaaat cacgaatgca ttggaaacct ggggagccct cggccaggat      120

attaacctgg acatccccag cttccagatg agcgacgaca tcgatgacat caagtgggag      180

aaaaccagcg acaagaagaa gatcgcccag ttccggaaag agaaagagac attcaaagag      240

aaggacacct acaagctgtt caagaacggc accctgaaga tcaagcacct gaaaaccgac      300

gaccaggaca tctataaggt gtccatctac cacaccaagg gcaagaacgt gctggaaaag      360

atcttcgacc tcaagatcca agagcgggtg tccaagccta agatcagctg gacctgcatc      420

aacaccacac tgacctgcga agtgatgaac ggcacagacc ccgagctgaa cctgtaccag      480

gatggcaaac acctgaagct gagccagcgc gtgatcaccc acaagtggac aacaagcctg      540

agcgccaagt tcaagtgcac cgccggaaac aaagtgtcta aagagtccag cgtcgagccc      600

gtgtcttgcc ctgaaaaagg actggacatc tacctgatca tcggcatctg tggcggcgga      660

tccctgctga tggtgtttgt ggctctgctg gtgttctaca tcacacagct gggactgcac      720

atctggcagc tgagaagcca gtgcatgtgg cccagagaga cacagctgct gctggaagtg      780

cctcctagca ccgaggatgc cagaagctgt cagttccccg aggaagagag aggcgagaga      840

tccgccgagg aaaaaggcag actgggcgac ctgtgggtcc gagtgaaatt cagccgcagc      900

gccgatgctc ctgcctataa gcagggacag aaccagctgt acaacgagct gaatctgggg      960

cgcagagaag agtacgatgt gctggacaag cggagaggca gagatcctga gatgggcggc     1020

aagcccagac ggaagaatcc tcaagagggc ctgtataatg agctgcagaa agacaagatg     1080

gccgaggcct acagcgagat cggaatgaag ggcgagcgca gaagaggcaa gggacacgat     1140

ggactgtatc agggcctgag caccgccacc aaggatacct atgatgccct gcacatgcag     1200

gccctgcctc caaga                                                      1215


<210>  73
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.Gz polypeptide sequence

<400>  73

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly 
            20                  25                  30          


Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser 
        35                  40                  45              


Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys 
    50                  55                  60                  


Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr 
65                  70                  75                  80  


Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr 
                85                  90                  95      


Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr His Thr Lys Gly Lys 
            100                 105                 110         


Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser 
        115                 120                 125             


Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu 
    130                 135                 140                 


Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys 
145                 150                 155                 160 


His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser 
                165                 170                 175     


Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu 
            180                 185                 190         


Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr 
        195                 200                 205             


Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val 
    210                 215                 220                 


Ala Leu Leu Val Phe Tyr Ile Thr Gln Leu Gly Leu His Ile Trp Gln 
225                 230                 235                 240 


Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu 
                245                 250                 255     


Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu 
            260                 265                 270         


Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu 
        275                 280                 285             


Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    290                 295                 300                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
305                 310                 315                 320 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                325                 330                 335     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            340                 345                 350         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        355                 360                 365             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    370                 375                 380                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
385                 390                 395                 400 


Pro Arg 
        


<210>  74
<211>  1206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD2.8.DH.Gz polynucleotide sequence

<400>  74
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgcttctgca tgccgccaga       60

cctaaagaaa tcacgaatgc attggaaacc tggggagccc tcggccagga tattaacctg      120

gacatcccca gcttccagat gagcgacgac atcgatgaca tcaagtggga gaaaaccagc      180

gacaagaaga agatcgccca gttccggaaa gagaaagaga cattcaaaga gaaggacacc      240

tacaagctgt tcaagaacgg caccctgaag atcaagcacc tgaaaaccga cgaccaggac      300

atctataagg tgtccatcta ccacaccaag ggcaagaacg tgctggaaaa gatcttcgac      360

ctcaagatcc aagagcgggt gtccaagcct aagatcagct ggacctgcat caacaccaca      420

ctgacctgcg aagtgatgaa cggcacagac cccgagctga acctgtacca ggatggcaaa      480

cacctgaagc tgagccagcg cgtgatcacc cacaagtgga caacaagcct gagcgccaag      540

ttcaagtgca ccgccggaaa caaagtgtct aaagagtcca gcgtcgagcc cgtgtcttgc      600

cctgaaaaag gactggacat ctacctgatc atcggcatct gtggcggcgg atccctgctg      660

atggtgtttg tggctctgct ggtgttctac atcacacagc tgggactgca catctggcag      720

ctgagaagcc agtgcatgtg gcccagagag acacagctgc tgctggaagt gcctcctagc      780

accgaggatg ccagaagctg tcagttcccc gaggaagaga gaggcgagag atccgccgag      840

gaaaaaggca gactgggcga cctgtgggtc cgagtgaaat tcagccgcag cgccgatgct      900

cctgcctata agcagggaca gaaccagctg tacaacgagc tgaatctggg gcgcagagaa      960

gagtacgatg tgctggacaa gcggagaggc agagatcctg agatgggcgg caagcccaga     1020

cggaagaatc ctcaagaggg cctgtataat gagctgcaga aagacaagat ggccgaggcc     1080

tacagcgaga tcggaatgaa gggcgagcgc agaagaggca agggacacga tggactgtat     1140

cagggcctga gcaccgccac caaggatacc tatgatgccc tgcacatgca ggccctgcct     1200

ccaaga                                                                1206


<210>  75

<400>  75
000


<210>  76

<400>  76
000


<210>  77

<400>  77
000


<210>  78

<400>  78
000


<210>  79
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  79

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  80
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dSaCas9

<400>  80

Met Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Ala Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  81
<211>  1368
<212>  PRT
<213>  Staphylococcus pyogenes


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  81

Xaa Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  82
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCas9 synthetic polypeptide

<400>  82

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  83
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clo051

<400>  83

Glu Gly Ile Lys Ser Asn Ile Ser Leu Leu Lys Asp Glu Leu Arg Gly 
1               5                   10                  15      


Gln Ile Ser His Ile Ser His Glu Tyr Leu Ser Leu Ile Asp Leu Ala 
            20                  25                  30          


Phe Asp Ser Lys Gln Asn Arg Leu Phe Glu Met Lys Val Leu Glu Leu 
        35                  40                  45              


Leu Val Asn Glu Tyr Gly Phe Lys Gly Arg His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ile Val Tyr Ser Thr Thr Leu Glu Asp Asn Phe Gly 
65                  70                  75                  80  


Ile Ile Val Asp Thr Lys Ala Tyr Ser Glu Gly Tyr Ser Leu Pro Ile 
                85                  90                  95      


Ser Gln Ala Asp Glu Met Glu Arg Tyr Val Arg Glu Asn Ser Asn Arg 
            100                 105                 110         


Asp Glu Glu Val Asn Pro Asn Lys Trp Trp Glu Asn Phe Ser Glu Glu 
        115                 120                 125             


Val Lys Lys Tyr Tyr Phe Val Phe Ile Ser Gly Ser Phe Lys Gly Lys 
    130                 135                 140                 


Phe Glu Glu Gln Leu Arg Arg Leu Ser Met Thr Thr Gly Val Asn Gly 
145                 150                 155                 160 


Ser Ala Val Asn Val Val Asn Leu Leu Leu Gly Ala Glu Lys Ile Arg 
                165                 170                 175     


Ser Gly Glu Met Thr Ile Glu Glu Leu Glu Arg Ala Met Phe Asn Asn 
            180                 185                 190         


Ser Glu Phe Ile Leu Lys Tyr 
        195                 


<210>  84
<211>  1591
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCas9-Clo051 fusion protein

<400>  84

Met Ala Pro Lys Lys Lys Arg Lys Val Glu Gly Ile Lys Ser Asn Ile 
1               5                   10                  15      


Ser Leu Leu Lys Asp Glu Leu Arg Gly Gln Ile Ser His Ile Ser His 
            20                  25                  30          


Glu Tyr Leu Ser Leu Ile Asp Leu Ala Phe Asp Ser Lys Gln Asn Arg 
        35                  40                  45              


Leu Phe Glu Met Lys Val Leu Glu Leu Leu Val Asn Glu Tyr Gly Phe 
    50                  55                  60                  


Lys Gly Arg His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ile Val Tyr 
65                  70                  75                  80  


Ser Thr Thr Leu Glu Asp Asn Phe Gly Ile Ile Val Asp Thr Lys Ala 
                85                  90                  95      


Tyr Ser Glu Gly Tyr Ser Leu Pro Ile Ser Gln Ala Asp Glu Met Glu 
            100                 105                 110         


Arg Tyr Val Arg Glu Asn Ser Asn Arg Asp Glu Glu Val Asn Pro Asn 
        115                 120                 125             


Lys Trp Trp Glu Asn Phe Ser Glu Glu Val Lys Lys Tyr Tyr Phe Val 
    130                 135                 140                 


Phe Ile Ser Gly Ser Phe Lys Gly Lys Phe Glu Glu Gln Leu Arg Arg 
145                 150                 155                 160 


Leu Ser Met Thr Thr Gly Val Asn Gly Ser Ala Val Asn Val Val Asn 
                165                 170                 175     


Leu Leu Leu Gly Ala Glu Lys Ile Arg Ser Gly Glu Met Thr Ile Glu 
            180                 185                 190         


Glu Leu Glu Arg Ala Met Phe Asn Asn Ser Glu Phe Ile Leu Lys Tyr 
        195                 200                 205             


Gly Gly Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
    210                 215                 220                 


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
225                 230                 235                 240 


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
                245                 250                 255     


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
            260                 265                 270         


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
        275                 280                 285             


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
    290                 295                 300                 


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
305                 310                 315                 320 


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
                325                 330                 335     


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
            340                 345                 350         


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
        355                 360                 365             


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
    370                 375                 380                 


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
385                 390                 395                 400 


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
                405                 410                 415     


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
            420                 425                 430         


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
        435                 440                 445             


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
    450                 455                 460                 


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
                485                 490                 495     


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
            500                 505                 510         


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
        515                 520                 525             


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
    530                 535                 540                 


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
545                 550                 555                 560 


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
                565                 570                 575     


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
            580                 585                 590         


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
        595                 600                 605             


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
    610                 615                 620                 


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
625                 630                 635                 640 


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
                645                 650                 655     


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
            660                 665                 670         


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
        675                 680                 685             


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
    690                 695                 700                 


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
705                 710                 715                 720 


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
                725                 730                 735     


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
            740                 745                 750         


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
        755                 760                 765             


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
    770                 775                 780                 


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
785                 790                 795                 800 


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
                805                 810                 815     


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
            820                 825                 830         


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
        835                 840                 845             


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
    850                 855                 860                 


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
865                 870                 875                 880 


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
                885                 890                 895     


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
            900                 905                 910         


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
        915                 920                 925             


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
    930                 935                 940                 


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
945                 950                 955                 960 


Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala 
                965                 970                 975     


Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg 
            980                 985                 990         


Met Lys Arg Ile Glu Glu Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu 
        995                 1000                 1005             


Lys Glu  His Pro Val Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu 
    1010                 1015                 1020             


Tyr Leu  Tyr Tyr Leu Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln 
    1025                 1030                 1035             


Glu Leu  Asp Ile Asn Arg Leu  Ser Asp Tyr Asp Val  Asp Ala Ile 
    1040                 1045                 1050             


Val Pro  Gln Ser Phe Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val 
    1055                 1060                 1065             


Leu Thr  Arg Ser Asp Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro 
    1070                 1075                 1080             


Ser Glu  Glu Val Val Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu 
    1085                 1090                 1095             


Leu Asn  Ala Lys Leu Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr 
    1100                 1105                 1110             


Lys Ala  Glu Arg Gly Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe 
    1115                 1120                 1125             


Ile Lys  Arg Gln Leu Val Glu  Thr Arg Gln Ile Thr  Lys His Val 
    1130                 1135                 1140             


Ala Gln  Ile Leu Asp Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn 
    1145                 1150                 1155             


Asp Lys  Leu Ile Arg Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys 
    1160                 1165                 1170             


Leu Val  Ser Asp Phe Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg 
    1175                 1180                 1185             


Glu Ile  Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
    1190                 1195                 1200             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1205                 1210                 1215             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1220                 1225                 1230             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1235                 1240                 1245             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1250                 1255                 1260             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1265                 1270                 1275             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1280                 1285                 1290             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1295                 1300                 1305             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1310                 1315                 1320             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1325                 1330                 1335             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1340                 1345                 1350             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1355                 1360                 1365             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1370                 1375                 1380             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1385                 1390                 1395             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1400                 1405                 1410             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1415                 1420                 1425             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1430                 1435                 1440             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1445                 1450                 1455             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1460                 1465                 1470             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1475                 1480                 1485             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1490                 1495                 1500             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1505                 1510                 1515             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1520                 1525                 1530             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1535                 1540                 1545             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1550                 1555                 1560             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1565                 1570                 1575             


Gly Asp  Gly Ser Pro Lys Lys  Lys Arg Lys Val Ser  Ser 
    1580                 1585                 1590     


<210>  85
<211>  4776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dCas9-Clo051 fusion protein

<400>  85
atggcaccaa agaagaaaag aaaagtggag ggcatcaagt caaacatcag cctgctgaaa       60

gacgaactgc ggggacagat tagtcacatc agtcacgagt acctgtcact gattgatctg      120

gccttcgaca gcaagcagaa tagactgttt gagatgaaag tgctggaact gctggtcaac      180

gagtatggct tcaagggcag acatctgggc gggtctagga aacctgacgg catcgtgtac      240

agtaccacac tggaagacaa cttcggaatc attgtcgata ccaaggctta ttccgagggc      300

tactctctgc caattagtca ggcagatgag atggaaaggt acgtgcgcga aaactcaaat      360

agggacgagg aagtcaaccc caataagtgg tgggagaatt tcagcgagga agtgaagaaa      420

tactacttcg tctttatctc aggcagcttc aaagggaagt ttgaggaaca gctgcggaga      480

ctgtccatga ctaccggggt gaacggatct gctgtcaacg tggtcaatct gctgctgggc      540

gcagaaaaga tcaggtccgg ggagatgaca attgaggaac tggaacgcgc catgttcaac      600

aattctgagt ttatcctgaa gtatggaggc gggggaagcg ataagaaata ctccatcgga      660

ctggccattg gcaccaattc cgtgggctgg gctgtcatca cagacgagta caaggtgcca      720

agcaagaagt tcaaggtcct ggggaacacc gatcgccaca gtatcaagaa aaatctgatt      780

ggagccctgc tgttcgactc aggcgagact gctgaagcaa cccgactgaa gcggactgct      840

aggcgccgat atacccggag aaaaaatcgg atctgctacc tgcaggaaat tttcagcaac      900

gagatggcca aggtggacga tagtttcttt caccgcctgg aggaatcatt cctggtggag      960

gaagataaga aacacgagcg gcatcccatc tttggcaaca ttgtggacga agtcgcttat     1020

cacgagaagt accctactat ctatcatctg aggaagaaac tggtggactc caccgataag     1080

gcagacctgc gcctgatcta tctggccctg gctcacatga tcaagttccg ggggcatttt     1140

ctgatcgagg gagatctgaa ccctgacaat tctgatgtgg acaagctgtt catccagctg     1200

gtccagacat acaatcagct gtttgaggaa aacccaatta atgcctcagg cgtggacgca     1260

aaggccatcc tgagcgccag actgtccaaa tctaggcgcc tggaaaacct gatcgctcag     1320

ctgccaggag agaagaaaaa cggcctgttt gggaatctga ttgcactgtc cctgggcctg     1380

acacccaact tcaagtctaa ttttgatctg gccgaggacg ctaagctgca gctgtccaaa     1440

gacacttatg acgatgacct ggataacctg ctggctcaga tcggcgatca gtacgcagac     1500

ctgttcctgg ccgctaagaa tctgagtgac gccatcctgc tgtcagatat tctgcgcgtg     1560

aacacagaga ttactaaggc cccactgagt gcttcaatga tcaaaagata tgacgagcac     1620

catcaggatc tgaccctgct gaaggctctg gtgaggcagc agctgcccga gaaatacaag     1680

gaaatcttct ttgatcagag caagaatgga tacgccggct atattgacgg cggggcttcc     1740

caggaggagt tctacaagtt catcaagccc attctggaaa agatggacgg caccgaggaa     1800

ctgctggtga agctgaatcg ggaggacctg ctgagaaaac agaggacatt tgataacgga     1860

agcatccctc accagattca tctgggcgaa ctgcacgcca tcctgcgacg gcaggaggac     1920

ttctacccat ttctgaagga taaccgcgag aaaatcgaaa agatcctgac cttcagaatc     1980

ccctactatg tggggcctct ggcacgggga aatagtagat ttgcctggat gacaagaaag     2040

tcagaggaaa ctatcacccc ctggaacttc gaggaagtgg tcgataaagg cgctagcgca     2100

cagtccttca ttgaaaggat gacaaatttt gacaagaacc tgccaaatga gaaggtgctg     2160

cccaaacaca gcctgctgta cgaatatttc acagtgtata acgagctgac taaagtgaag     2220

tacgtcaccg aagggatgcg caagcccgca ttcctgtccg gagagcagaa gaaagccatc     2280

gtggacctgc tgtttaagac aaatcggaaa gtgactgtca aacagctgaa ggaagactat     2340

ttcaagaaaa ttgagtgttt cgattcagtg gaaatcagcg gcgtcgagga caggtttaac     2400

gcctccctgg ggacctacca cgatctgctg aagatcatca aggataagga cttcctggac     2460

aacgaggaaa atgaggacat cctggaggac attgtgctga cactgactct gtttgaggat     2520

cgcgaaatga tcgaggaacg actgaagact tatgcccatc tgttcgatga caaagtgatg     2580

aagcagctga aaagaaggcg ctacaccgga tggggacgcc tgagccgaaa actgatcaat     2640

gggattagag acaagcagag cggaaaaact atcctggact ttctgaagtc cgatggcttc     2700

gccaacagga acttcatgca gctgattcac gatgactctc tgaccttcaa ggaggacatc     2760

cagaaagcac aggtgtctgg ccagggggac agtctgcacg agcatatcgc aaacctggcc     2820

ggcagccccg ccatcaagaa agggattctg cagaccgtga aggtggtgga cgaactggtc     2880

aaggtcatgg gacgacacaa acctgagaac atcgtgattg agatggcccg cgaaaatcag     2940

acaactcaga agggccagaa aaacagtcga gaacggatga agagaatcga ggaaggcatc     3000

aaggagctgg ggtcacagat cctgaaggag catcctgtgg aaaacactca gctgcagaat     3060

gagaaactgt atctgtacta tctgcagaat ggacgggata tgtacgtgga ccaggagctg     3120

gatattaaca gactgagtga ttatgacgtg gatgccatcg tccctcagag cttcctgaag     3180

gatgactcca ttgacaacaa ggtgctgacc aggtccgaca agaaccgcgg caaatcagat     3240

aatgtgccaa gcgaggaagt ggtcaagaaa atgaagaact actggaggca gctgctgaat     3300

gccaagctga tcacacagcg gaaatttgat aacctgacta aggcagaaag aggaggcctg     3360

tctgagctgg acaaggccgg cttcatcaag cggcagctgg tggagacaag acagatcact     3420

aagcacgtcg ctcagattct ggatagcaga atgaacacaa agtacgatga aaacgacaag     3480

ctgatcaggg aggtgaaagt cattactctg aaatccaagc tggtgtctga ctttagaaag     3540

gatttccagt tttataaagt cagggagatc aacaactacc accatgctca tgacgcatac     3600

ctgaacgcag tggtcgggac cgccctgatt aagaaatacc ccaagctgga gtccgagttc     3660

gtgtacggag actataaagt gtacgatgtc cggaagatga tcgccaaatc tgagcaggaa     3720

attggcaagg ccaccgctaa gtatttcttt tacagtaaca tcatgaattt ctttaagacc     3780

gaaatcacac tggcaaatgg ggagatcaga aaaaggcctc tgattgagac caacggggag     3840

acaggagaaa tcgtgtggga caagggaagg gattttgcta ccgtgcgcaa agtcctgtcc     3900

atgccccaag tgaatattgt caagaaaact gaagtgcaga ccgggggatt ctctaaggag     3960

agtattctgc ctaagcgaaa ctctgataaa ctgatcgccc ggaagaaaga ctgggacccc     4020

aagaagtatg gcgggttcga ctctccaaca gtggcttaca gtgtcctggt ggtcgcaaag     4080

gtggaaaagg ggaagtccaa gaaactgaag tctgtcaaag agctgctggg aatcactatt     4140

atggaacgca gctccttcga gaagaatcct atcgattttc tggaagccaa gggctataaa     4200

gaggtgaaga aagacctgat cattaagctg ccaaaatact cactgtttga gctggaaaac     4260

ggacgaaagc gaatgctggc aagcgccgga gaactgcaga agggcaatga gctggccctg     4320

ccctccaaat acgtgaactt cctgtatctg gctagccact acgagaaact gaaggggtcc     4380

cctgaggata acgaacagaa gcagctgttt gtggagcagc acaaacatta tctggacgag     4440

atcattgaac agatttcaga gttcagcaag agagtgatcc tggctgacgc aaatctggat     4500

aaagtcctga gcgcatacaa caagcaccga gacaaaccaa tccgggagca ggccgaaaat     4560

atcattcatc tgttcaccct gacaaacctg ggcgcccctg cagccttcaa gtattttgac     4620

accacaatcg atcggaagag atacacttct accaaagagg tgctggatgc taccctgatc     4680

caccagagta ttaccggcct gtatgagaca cgcatcgacc tgtcacagct gggaggcgat     4740

gggagcccca agaaaaagcg gaaggtgtct agttaa                               4776


<210>  86
<211>  1588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dCas9-Clo051 fusion protein

<400>  86

Met Pro Lys Lys Lys Arg Lys Val Glu Gly Ile Lys Ser Asn Ile Ser 
1               5                   10                  15      


Leu Leu Lys Asp Glu Leu Arg Gly Gln Ile Ser His Ile Ser His Glu 
            20                  25                  30          


Tyr Leu Ser Leu Ile Asp Leu Ala Phe Asp Ser Lys Gln Asn Arg Leu 
        35                  40                  45              


Phe Glu Met Lys Val Leu Glu Leu Leu Val Asn Glu Tyr Gly Phe Lys 
    50                  55                  60                  


Gly Arg His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ile Val Tyr Ser 
65                  70                  75                  80  


Thr Thr Leu Glu Asp Asn Phe Gly Ile Ile Val Asp Thr Lys Ala Tyr 
                85                  90                  95      


Ser Glu Gly Tyr Ser Leu Pro Ile Ser Gln Ala Asp Glu Met Glu Arg 
            100                 105                 110         


Tyr Val Arg Glu Asn Ser Asn Arg Asp Glu Glu Val Asn Pro Asn Lys 
        115                 120                 125             


Trp Trp Glu Asn Phe Ser Glu Glu Val Lys Lys Tyr Tyr Phe Val Phe 
    130                 135                 140                 


Ile Ser Gly Ser Phe Lys Gly Lys Phe Glu Glu Gln Leu Arg Arg Leu 
145                 150                 155                 160 


Ser Met Thr Thr Gly Val Asn Gly Ser Ala Val Asn Val Val Asn Leu 
                165                 170                 175     


Leu Leu Gly Ala Glu Lys Ile Arg Ser Gly Glu Met Thr Ile Glu Glu 
            180                 185                 190         


Leu Glu Arg Ala Met Phe Asn Asn Ser Glu Phe Ile Leu Lys Tyr Gly 
        195                 200                 205             


Gly Gly Gly Ser Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
    210                 215                 220                 


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
225                 230                 235                 240 


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
                245                 250                 255     


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
            260                 265                 270         


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
        275                 280                 285             


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
    290                 295                 300                 


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
305                 310                 315                 320 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
                325                 330                 335     


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
            340                 345                 350         


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
        355                 360                 365             


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
    370                 375                 380                 


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
385                 390                 395                 400 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
                405                 410                 415     


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
            420                 425                 430         


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
        435                 440                 445             


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
    450                 455                 460                 


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
                485                 490                 495     


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
            500                 505                 510         


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
        515                 520                 525             


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
    530                 535                 540                 


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
545                 550                 555                 560 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
                565                 570                 575     


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
            580                 585                 590         


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
        595                 600                 605             


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
    610                 615                 620                 


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
625                 630                 635                 640 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
                645                 650                 655     


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
            660                 665                 670         


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
        675                 680                 685             


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
    690                 695                 700                 


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
705                 710                 715                 720 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
                725                 730                 735     


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
            740                 745                 750         


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
        755                 760                 765             


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
    770                 775                 780                 


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
785                 790                 795                 800 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
                805                 810                 815     


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
            820                 825                 830         


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
        835                 840                 845             


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
    850                 855                 860                 


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
865                 870                 875                 880 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
                885                 890                 895     


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
            900                 905                 910         


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
        915                 920                 925             


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
    930                 935                 940                 


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
945                 950                 955                 960 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
                965                 970                 975     


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
            980                 985                 990         


Lys Arg Ile Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
        995                 1000                 1005             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1010                 1015                 1020             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1025                 1030                 1035             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  Ala Ile Val 
    1040                 1045                 1050             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1055                 1060                 1065             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1070                 1075                 1080             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1085                 1090                 1095             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1100                 1105                 1110             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1115                 1120                 1125             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1130                 1135                 1140             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1145                 1150                 1155             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1160                 1165                 1170             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1175                 1180                 1185             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1190                 1195                 1200             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1205                 1210                 1215             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1220                 1225                 1230             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1235                 1240                 1245             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1250                 1255                 1260             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1265                 1270                 1275             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1280                 1285                 1290             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1295                 1300                 1305             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1310                 1315                 1320             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1325                 1330                 1335             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1340                 1345                 1350             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1355                 1360                 1365             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1370                 1375                 1380             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1385                 1390                 1395             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1400                 1405                 1410             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1415                 1420                 1425             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1430                 1435                 1440             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1445                 1450                 1455             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1460                 1465                 1470             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1475                 1480                 1485             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1490                 1495                 1500             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1505                 1510                 1515             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1520                 1525                 1530             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1535                 1540                 1545             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1550                 1555                 1560             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1565                 1570                 1575             


Asp Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1580                 1585             


<210>  87
<211>  4767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dCas9-Clo051 fusion protein

<400>  87
atgcctaaga agaagcggaa ggtggaaggc atcaaaagca acatctccct cctgaaagac       60

gaactccggg ggcagattag ccacattagt cacgaatacc tctccctcat cgacctggct      120

ttcgatagca agcagaacag gctctttgag atgaaagtgc tggaactgct cgtcaatgag      180

tacgggttca agggtcgaca cctcggcgga tctaggaaac cagacggcat cgtgtatagt      240

accacactgg aagacaactt tgggatcatt gtggatacca aggcatactc tgagggttat      300

agtctgccca tttcacaggc cgacgagatg gaacggtacg tgcgcgagaa ctcaaataga      360

gatgaggaag tcaaccctaa caagtggtgg gagaacttct ctgaggaagt gaagaaatac      420

tacttcgtct ttatcagcgg gtccttcaag ggtaaatttg aggaacagct caggagactg      480

agcatgacta ccggcgtgaa tggcagcgcc gtcaacgtgg tcaatctgct cctgggcgct      540

gaaaagattc ggagcggaga gatgaccatc gaagagctgg agagggcaat gtttaataat      600

agcgagttta tcctgaaata cggtggcggt ggatccgata aaaagtattc tattggttta      660

gccatcggca ctaattccgt tggatgggct gtcataaccg atgaatacaa agtaccttca      720

aagaaattta aggtgttggg gaacacagac cgtcattcga ttaaaaagaa tcttatcggt      780

gccctcctat tcgatagtgg cgaaacggca gaggcgactc gcctgaaacg aaccgctcgg      840

agaaggtata cacgtcgcaa gaaccgaata tgttacttac aagaaatttt tagcaatgag      900

atggccaaag ttgacgattc tttctttcac cgtttggaag agtccttcct tgtcgaagag      960

gacaagaaac atgaacggca ccccatcttt ggaaacatag tagatgaggt ggcatatcat     1020

gaaaagtacc caacgattta tcacctcaga aaaaagctag ttgactcaac tgataaagcg     1080

gacctgaggt taatctactt ggctcttgcc catatgataa agttccgtgg gcactttctc     1140

attgagggtg atctaaatcc ggacaactcg gatgtcgaca aactgttcat ccagttagta     1200

caaacctata atcagttgtt tgaagagaac cctataaatg caagtggcgt ggatgcgaag     1260

gctattctta gcgcccgcct ctctaaatcc cgacggctag aaaacctgat cgcacaatta     1320

cccggagaga agaaaaatgg gttgttcggt aaccttatag cgctctcact aggcctgaca     1380

ccaaatttta agtcgaactt cgacttagct gaagatgcca aattgcagct tagtaaggac     1440

acgtacgatg acgatctcga caatctactg gcacaaattg gagatcagta tgcggactta     1500

tttttggctg ccaaaaacct tagcgatgca atcctcctat ctgacatact gagagttaat     1560

actgagatta ccaaggcgcc gttatccgct tcaatgatca aaaggtacga tgaacatcac     1620

caagacttga cacttctcaa ggccctagtc cgtcagcaac tgcctgagaa atataaggaa     1680

atattctttg atcagtcgaa aaacgggtac gcaggttata ttgacggcgg agcgagtcaa     1740

gaggaattct acaagtttat caaacccata ttagagaaga tggatgggac ggaagagttg     1800

cttgtaaaac tcaatcgcga agatctactg cgaaagcagc ggactttcga caacggtagc     1860

attccacatc aaatccactt aggcgaattg catgctatac ttagaaggca ggaggatttt     1920

tatccgttcc tcaaagacaa tcgtgaaaag attgagaaaa tcctaacctt tcgcatacct     1980

tactatgtgg gacccctggc ccgagggaac tctcggttcg catggatgac aagaaagtcc     2040

gaagaaacga ttactccatg gaattttgag gaagttgtcg ataaaggtgc gtcagctcaa     2100

tcgttcatcg agaggatgac caactttgac aagaatttac cgaacgaaaa agtattgcct     2160

aagcacagtt tactttacga gtatttcaca gtgtacaatg aactcacgaa agttaagtat     2220

gtcactgagg gcatgcgtaa acccgccttt ctaagcggag aacagaagaa agcaatagta     2280

gatctgttat tcaagaccaa ccgcaaagtg acagttaagc aattgaaaga ggactacttt     2340

aagaaaattg aatgcttcga ttctgtcgag atctccgggg tagaagatcg atttaatgcg     2400

tcacttggta cgtatcatga cctcctaaag ataattaaag ataaggactt cctggataac     2460

gaagagaatg aagatatctt agaagatata gtgttgactc ttaccctctt tgaagatcgg     2520

gaaatgattg aggaaagact aaaaacatac gctcacctgt tcgacgataa ggttatgaaa     2580

cagttaaaga ggcgtcgcta tacgggctgg ggacgattgt cgcggaaact tatcaacggg     2640

ataagagaca agcaaagtgg taaaactatt ctcgattttc taaagagcga cggcttcgcc     2700

aataggaact ttatgcagct gatccatgat gactctttaa ccttcaaaga ggatatacaa     2760

aaggcacagg tttccggaca aggggactca ttgcacgaac atattgcgaa tcttgctggt     2820

tcgccagcca tcaaaaaggg catactccag acagtcaaag tagtggatga gctagttaag     2880

gtcatgggac gtcacaaacc ggaaaacatt gtaatcgaga tggcacgcga aaatcaaacg     2940

actcagaagg ggcaaaaaaa cagtcgagag cggatgaaga gaatagaaga gggtattaaa     3000

gaactgggca gccagatctt aaaggagcat cctgtggaaa atacccaatt gcagaacgag     3060

aaactttacc tctattacct acaaaatgga agggacatgt atgttgatca ggaactggac     3120

ataaaccgtt tatctgatta cgacgtcgat gccattgtac cccaatcctt tttgaaggac     3180

gattcaatcg acaataaagt gcttacacgc tcggataaga accgagggaa aagtgacaat     3240

gttccaagcg aggaagtcgt aaagaaaatg aagaactatt ggcggcagct cctaaatgcg     3300

aaactgataa cgcaaagaaa gttcgataac ttaactaaag ctgagagggg tggcttgtct     3360

gaacttgaca aggccggatt tattaaacgt cagctcgtgg aaacccgcca aatcacaaag     3420

catgttgcac agatactaga ttcccgaatg aatacgaaat acgacgagaa cgataagctg     3480

attcgggaag tcaaagtaat cactttaaag tcaaaattgg tgtcggactt cagaaaggat     3540

tttcaattct ataaagttag ggagataaat aactaccacc atgcgcacga cgcttatctt     3600

aatgccgtcg tagggaccgc actcattaag aaatacccga agctagaaag tgagtttgtg     3660

tatggtgatt acaaagttta tgacgtccgt aagatgatcg cgaaaagcga acaggagata     3720

ggcaaggcta cagccaaata cttcttttat tctaacatta tgaatttctt taagacggaa     3780

atcactctgg caaacggaga gatacgcaaa cgacctttaa ttgaaaccaa tggggagaca     3840

ggtgaaatcg tatgggataa gggccgggac ttcgcgacgg tgagaaaagt tttgtccatg     3900

ccccaagtca acatagtaaa gaaaactgag gtgcagaccg gagggttttc aaaggaatcg     3960

attcttccaa aaaggaatag tgataagctc atcgctcgta aaaaggactg ggacccgaaa     4020

aagtacggtg gcttcgatag ccctacagtt gcctattctg tcctagtagt ggcaaaagtt     4080

gagaagggaa aatccaagaa actgaagtca gtcaaagaat tattggggat aacgattatg     4140

gagcgctcgt cttttgaaaa gaaccccatc gacttccttg aggcgaaagg ttacaaggaa     4200

gtaaaaaagg atctcataat taaactacca aagtatagtc tgtttgagtt agaaaatggc     4260

cgaaaacgga tgttggctag cgccggagag cttcaaaagg ggaacgaact cgcactaccg     4320

tctaaatacg tgaatttcct gtatttagcg tcccattacg agaagttgaa aggttcacct     4380

gaagataacg aacagaagca actttttgtt gagcagcaca aacattatct cgacgaaatc     4440

atagagcaaa tttcggaatt cagtaagaga gtcatcctag ctgatgccaa tctggacaaa     4500

gtattaagcg catacaacaa gcacagggat aaacccatac gtgagcaggc ggaaaatatt     4560

atccatttgt ttactcttac caacctcggc gctccagccg cattcaagta ttttgacaca     4620

acgatagatc gcaaacgata cacttctacc aaggaggtgc tagacgcgac actgattcac     4680

caatccatca cgggattata tgaaactcgg atagatttgt cacagcttgg gggtgacgga     4740

tcccccaaga agaagaggaa agtctga                                         4767


<210>  88
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DHFR mutein enzyme

<400>  88

Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Phe Pro Trp Pro Pro Leu Arg Asn Glu Ser 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210>  89
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DHFR mutein enzyme

<400>  89
atggtcgggt ctctgaattg tatcgtcgcc gtgagtcaga acatgggcat tgggaagaat       60

ggcgatttcc catggccacc tctgcgcaac gagtcccgat actttcagcg gatgacaact      120

acctcctctg tggaagggaa acagaatctg gtcatcatgg gaaagaaaac ttggttcagc      180

attccagaga agaaccggcc cctgaaaggc agaatcaatc tggtgctgtc ccgagaactg      240

aaggagccac cacagggagc tcactttctg agccggtccc tggacgatgc actgaagctg      300

acagaacagc ctgagctggc caacaaagtc gatatggtgt ggatcgtcgg gggaagttca      360

gtgtataagg aggccatgaa tcaccccggc catctgaaac tgttcgtcac acggatcatg      420

caggactttg agagcgatac tttctttcct gaaattgacc tggagaagta caaactgctg      480

cccgaatatc ctggcgtgct gtccgatgtc caggaagaga aaggcatcaa atacaagttc      540

gaggtctatg agaagaatga c                                                561


<210>  90
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A peptide

<400>  90

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  91
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG-T2A peptide

<400>  91

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  92
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSG-T2A polynucleotide

<400>  92
ggatctggag agggaagggg aagcctgctg acctgtggag acgtggagga aaacccagga       60

cca                                                                     63


<210>  93
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A peptide

<400>  93

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  94
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG-E2A peptide

<400>  94

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  95
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A peptide

<400>  95

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  96
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   GSG-F2A peptide

<400>  96

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  97
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   P2A peptide

<400>  97

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  98
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG-P2A peptide

<400>  98

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  99
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PB transposase

<400>  99

Met Gly Ser Ser Leu Asp Asp Glu His Ile Leu Ser Ala Leu Leu Gln 
1               5                   10                  15      


Ser Asp Asp Glu Leu Val Gly Glu Asp Ser Asp Ser Glu Ile Ser Asp 
            20                  25                  30          


His Val Ser Glu Asp Asp Val Gln Ser Asp Thr Glu Glu Ala Phe Ile 
        35                  40                  45              


Asp Glu Val His Glu Val Gln Pro Thr Ser Ser Gly Ser Glu Ile Leu 
    50                  55                  60                  


Asp Glu Gln Asn Val Ile Glu Gln Pro Gly Ser Ser Leu Ala Ser Asn 
65                  70                  75                  80  


Arg Ile Leu Thr Leu Pro Gln Arg Thr Ile Arg Gly Lys Asn Lys His 
                85                  90                  95      


Cys Trp Ser Thr Ser Lys Ser Thr Arg Arg Ser Arg Val Ser Ala Leu 
            100                 105                 110         


Asn Ile Val Arg Ser Gln Arg Gly Pro Thr Arg Met Cys Arg Asn Ile 
        115                 120                 125             


Tyr Asp Pro Leu Leu Cys Phe Lys Leu Phe Phe Thr Asp Glu Ile Ile 
    130                 135                 140                 


Ser Glu Ile Val Lys Trp Thr Asn Ala Glu Ile Ser Leu Lys Arg Arg 
145                 150                 155                 160 


Glu Ser Met Thr Gly Ala Thr Phe Arg Asp Thr Asn Glu Asp Glu Ile 
                165                 170                 175     


Tyr Ala Phe Phe Gly Ile Leu Val Met Thr Ala Val Arg Lys Asp Asn 
            180                 185                 190         


His Met Ser Thr Asp Asp Leu Phe Asp Arg Ser Leu Ser Met Val Tyr 
        195                 200                 205             


Val Ser Val Met Ser Arg Asp Arg Phe Asp Phe Leu Ile Arg Cys Leu 
    210                 215                 220                 


Arg Met Asp Asp Lys Ser Ile Arg Pro Thr Leu Arg Glu Asn Asp Val 
225                 230                 235                 240 


Phe Thr Pro Val Arg Lys Ile Trp Asp Leu Phe Ile His Gln Cys Ile 
                245                 250                 255     


Gln Asn Tyr Thr Pro Gly Ala His Leu Thr Ile Asp Glu Gln Leu Leu 
            260                 265                 270         


Gly Phe Arg Gly Arg Cys Pro Phe Arg Met Tyr Ile Pro Asn Lys Pro 
        275                 280                 285             


Ser Lys Tyr Gly Ile Lys Ile Leu Met Met Cys Asp Ser Gly Tyr Lys 
    290                 295                 300                 


Tyr Met Ile Asn Gly Met Pro Tyr Leu Gly Arg Gly Thr Gln Thr Asn 
305                 310                 315                 320 


Gly Val Pro Leu Gly Glu Tyr Tyr Val Lys Glu Leu Ser Lys Pro Val 
                325                 330                 335     


His Gly Ser Cys Arg Asn Ile Thr Cys Asp Asn Trp Phe Thr Ser Ile 
            340                 345                 350         


Pro Leu Ala Lys Asn Leu Leu Gln Glu Pro Tyr Lys Leu Thr Ile Val 
        355                 360                 365             


Gly Thr Val Arg Ser Asn Lys Arg Glu Ile Pro Glu Val Leu Lys Asn 
    370                 375                 380                 


Ser Arg Ser Arg Pro Val Gly Thr Ser Met Phe Cys Phe Asp Gly Pro 
385                 390                 395                 400 


Leu Thr Leu Val Ser Tyr Lys Pro Lys Pro Ala Lys Met Val Tyr Leu 
                405                 410                 415     


Leu Ser Ser Cys Asp Glu Asp Ala Ser Ile Asn Glu Ser Thr Gly Lys 
            420                 425                 430         


Pro Gln Met Val Met Tyr Tyr Asn Gln Thr Lys Gly Gly Val Asp Thr 
        435                 440                 445             


Leu Asp Gln Met Cys Ser Val Met Thr Cys Ser Arg Lys Thr Asn Arg 
    450                 455                 460                 


Trp Pro Met Ala Leu Leu Tyr Gly Met Ile Asn Ile Ala Cys Ile Asn 
465                 470                 475                 480 


Ser Phe Ile Ile Tyr Ser His Asn Val Ser Ser Lys Gly Glu Lys Val 
                485                 490                 495     


Gln Ser Arg Lys Lys Phe Met Arg Asn Leu Tyr Met Ser Leu Thr Ser 
            500                 505                 510         


Ser Phe Met Arg Lys Arg Leu Glu Ala Pro Thr Leu Lys Arg Tyr Leu 
        515                 520                 525             


Arg Asp Asn Ile Ser Asn Ile Leu Pro Asn Glu Val Pro Gly Thr Ser 
    530                 535                 540                 


Asp Asp Ser Thr Glu Glu Pro Val Met Lys Lys Arg Thr Tyr Cys Thr 
545                 550                 555                 560 


Tyr Cys Pro Ser Lys Ile Arg Arg Lys Ala Asn Ala Ser Cys Lys Lys 
                565                 570                 575     


Cys Lys Lys Val Ile Cys Arg Glu His Asn Ile Asp Met Cys Gln Ser 
            580                 585                 590         


Cys Phe 
        


<210>  100
<211>  594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPB transposase

<400>  100

Met Gly Ser Ser Leu Asp Asp Glu His Ile Leu Ser Ala Leu Leu Gln 
1               5                   10                  15      


Ser Asp Asp Glu Leu Val Gly Glu Asp Ser Asp Ser Glu Val Ser Asp 
            20                  25                  30          


His Val Ser Glu Asp Asp Val Gln Ser Asp Thr Glu Glu Ala Phe Ile 
        35                  40                  45              


Asp Glu Val His Glu Val Gln Pro Thr Ser Ser Gly Ser Glu Ile Leu 
    50                  55                  60                  


Asp Glu Gln Asn Val Ile Glu Gln Pro Gly Ser Ser Leu Ala Ser Asn 
65                  70                  75                  80  


Arg Ile Leu Thr Leu Pro Gln Arg Thr Ile Arg Gly Lys Asn Lys His 
                85                  90                  95      


Cys Trp Ser Thr Ser Lys Ser Thr Arg Arg Ser Arg Val Ser Ala Leu 
            100                 105                 110         


Asn Ile Val Arg Ser Gln Arg Gly Pro Thr Arg Met Cys Arg Asn Ile 
        115                 120                 125             


Tyr Asp Pro Leu Leu Cys Phe Lys Leu Phe Phe Thr Asp Glu Ile Ile 
    130                 135                 140                 


Ser Glu Ile Val Lys Trp Thr Asn Ala Glu Ile Ser Leu Lys Arg Arg 
145                 150                 155                 160 


Glu Ser Met Thr Ser Ala Thr Phe Arg Asp Thr Asn Glu Asp Glu Ile 
                165                 170                 175     


Tyr Ala Phe Phe Gly Ile Leu Val Met Thr Ala Val Arg Lys Asp Asn 
            180                 185                 190         


His Met Ser Thr Asp Asp Leu Phe Asp Arg Ser Leu Ser Met Val Tyr 
        195                 200                 205             


Val Ser Val Met Ser Arg Asp Arg Phe Asp Phe Leu Ile Arg Cys Leu 
    210                 215                 220                 


Arg Met Asp Asp Lys Ser Ile Arg Pro Thr Leu Arg Glu Asn Asp Val 
225                 230                 235                 240 


Phe Thr Pro Val Arg Lys Ile Trp Asp Leu Phe Ile His Gln Cys Ile 
                245                 250                 255     


Gln Asn Tyr Thr Pro Gly Ala His Leu Thr Ile Asp Glu Gln Leu Leu 
            260                 265                 270         


Gly Phe Arg Gly Arg Cys Pro Phe Arg Val Tyr Ile Pro Asn Lys Pro 
        275                 280                 285             


Ser Lys Tyr Gly Ile Lys Ile Leu Met Met Cys Asp Ser Gly Thr Lys 
    290                 295                 300                 


Tyr Met Ile Asn Gly Met Pro Tyr Leu Gly Arg Gly Thr Gln Thr Asn 
305                 310                 315                 320 


Gly Val Pro Leu Gly Glu Tyr Tyr Val Lys Glu Leu Ser Lys Pro Val 
                325                 330                 335     


His Gly Ser Cys Arg Asn Ile Thr Cys Asp Asn Trp Phe Thr Ser Ile 
            340                 345                 350         


Pro Leu Ala Lys Asn Leu Leu Gln Glu Pro Tyr Lys Leu Thr Ile Val 
        355                 360                 365             


Gly Thr Val Arg Ser Asn Lys Arg Glu Ile Pro Glu Val Leu Lys Asn 
    370                 375                 380                 


Ser Arg Ser Arg Pro Val Gly Thr Ser Met Phe Cys Phe Asp Gly Pro 
385                 390                 395                 400 


Leu Thr Leu Val Ser Tyr Lys Pro Lys Pro Ala Lys Met Val Tyr Leu 
                405                 410                 415     


Leu Ser Ser Cys Asp Glu Asp Ala Ser Ile Asn Glu Ser Thr Gly Lys 
            420                 425                 430         


Pro Gln Met Val Met Tyr Tyr Asn Gln Thr Lys Gly Gly Val Asp Thr 
        435                 440                 445             


Leu Asp Gln Met Cys Ser Val Met Thr Cys Ser Arg Lys Thr Asn Arg 
    450                 455                 460                 


Trp Pro Met Ala Leu Leu Tyr Gly Met Ile Asn Ile Ala Cys Ile Asn 
465                 470                 475                 480 


Ser Phe Ile Ile Tyr Ser His Asn Val Ser Ser Lys Gly Glu Lys Val 
                485                 490                 495     


Gln Ser Arg Lys Lys Phe Met Arg Asn Leu Tyr Met Ser Leu Thr Ser 
            500                 505                 510         


Ser Phe Met Arg Lys Arg Leu Glu Ala Pro Thr Leu Lys Arg Tyr Leu 
        515                 520                 525             


Arg Asp Asn Ile Ser Asn Ile Leu Pro Lys Glu Val Pro Gly Thr Ser 
    530                 535                 540                 


Asp Asp Ser Thr Glu Glu Pro Val Met Lys Lys Arg Thr Tyr Cys Thr 
545                 550                 555                 560 


Tyr Cys Pro Ser Lys Ile Arg Arg Lys Ala Asn Ala Ser Cys Lys Lys 
                565                 570                 575     


Cys Lys Lys Val Ile Cys Arg Glu His Asn Ile Asp Met Cys Gln Ser 
            580                 585                 590         


Cys Phe 
        


<210>  101
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sleeping Beauty transposase

<400>  101

Met Gly Lys Ser Lys Glu Ile Ser Gln Asp Leu Arg Lys Lys Ile Val 
1               5                   10                  15      


Asp Leu His Lys Ser Gly Ser Ser Leu Gly Ala Ile Ser Lys Arg Leu 
            20                  25                  30          


Lys Val Pro Arg Ser Ser Val Gln Thr Ile Val Arg Lys Tyr Lys His 
        35                  40                  45              


His Gly Thr Thr Gln Pro Ser Tyr Arg Ser Gly Arg Arg Arg Val Leu 
    50                  55                  60                  


Ser Pro Arg Asp Glu Arg Thr Leu Val Arg Lys Val Gln Ile Asn Pro 
65                  70                  75                  80  


Arg Thr Thr Ala Lys Asp Leu Val Lys Met Leu Glu Glu Thr Gly Thr 
                85                  90                  95      


Lys Val Ser Ile Ser Thr Val Lys Arg Val Leu Tyr Arg His Asn Leu 
            100                 105                 110         


Lys Gly Arg Ser Ala Arg Lys Lys Pro Leu Leu Gln Asn Arg His Lys 
        115                 120                 125             


Lys Ala Arg Leu Arg Phe Ala Thr Ala His Gly Asp Lys Asp Arg Thr 
    130                 135                 140                 


Phe Trp Arg Asn Val Leu Trp Ser Asp Glu Thr Lys Ile Glu Leu Phe 
145                 150                 155                 160 


Gly His Asn Asp His Arg Tyr Val Trp Arg Lys Lys Gly Glu Ala Cys 
                165                 170                 175     


Lys Pro Lys Asn Thr Ile Pro Thr Val Lys His Gly Gly Gly Ser Ile 
            180                 185                 190         


Met Leu Trp Gly Cys Phe Ala Ala Gly Gly Thr Gly Ala Leu His Lys 
        195                 200                 205             


Ile Asp Gly Ile Met Arg Lys Glu Asn Tyr Val Asp Ile Leu Lys Gln 
    210                 215                 220                 


His Leu Lys Thr Ser Val Arg Lys Leu Lys Leu Gly Arg Lys Trp Val 
225                 230                 235                 240 


Phe Gln Met Asp Asn Asp Pro Lys His Thr Ser Lys Val Val Ala Lys 
                245                 250                 255     


Trp Leu Lys Asp Asn Lys Val Lys Val Leu Glu Trp Pro Ser Gln Ser 
            260                 265                 270         


Pro Asp Leu Asn Pro Ile Glu Asn Leu Trp Ala Glu Leu Lys Lys Arg 
        275                 280                 285             


Val Arg Ala Arg Arg Pro Thr Asn Leu Thr Gln Leu His Gln Leu Cys 
    290                 295                 300                 


Gln Glu Glu Trp Ala Lys Ile His Pro Thr Tyr Cys Gly Lys Leu Val 
305                 310                 315                 320 


Glu Gly Tyr Pro Lys Arg Leu Thr Gln Val Lys Gln Phe Lys Gly Asn 
                325                 330                 335     


Ala Thr Lys Tyr 
            340 


<210>  102
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hyperactive Sleeping Beauty (SB100X) transposase

<400>  102

Met Gly Lys Ser Lys Glu Ile Ser Gln Asp Leu Arg Lys Arg Ile Val 
1               5                   10                  15      


Asp Leu His Lys Ser Gly Ser Ser Leu Gly Ala Ile Ser Lys Arg Leu 
            20                  25                  30          


Ala Val Pro Arg Ser Ser Val Gln Thr Ile Val Arg Lys Tyr Lys His 
        35                  40                  45              


His Gly Thr Thr Gln Pro Ser Tyr Arg Ser Gly Arg Arg Arg Val Leu 
    50                  55                  60                  


Ser Pro Arg Asp Glu Arg Thr Leu Val Arg Lys Val Gln Ile Asn Pro 
65                  70                  75                  80  


Arg Thr Thr Ala Lys Asp Leu Val Lys Met Leu Glu Glu Thr Gly Thr 
                85                  90                  95      


Lys Val Ser Ile Ser Thr Val Lys Arg Val Leu Tyr Arg His Asn Leu 
            100                 105                 110         


Lys Gly His Ser Ala Arg Lys Lys Pro Leu Leu Gln Asn Arg His Lys 
        115                 120                 125             


Lys Ala Arg Leu Arg Phe Ala Thr Ala His Gly Asp Lys Asp Arg Thr 
    130                 135                 140                 


Phe Trp Arg Asn Val Leu Trp Ser Asp Glu Thr Lys Ile Glu Leu Phe 
145                 150                 155                 160 


Gly His Asn Asp His Arg Tyr Val Trp Arg Lys Lys Gly Glu Ala Cys 
                165                 170                 175     


Lys Pro Lys Asn Thr Ile Pro Thr Val Lys His Gly Gly Gly Ser Ile 
            180                 185                 190         


Met Leu Trp Gly Cys Phe Ala Ala Gly Gly Thr Gly Ala Leu His Lys 
        195                 200                 205             


Ile Asp Gly Ile Met Asp Ala Val Gln Tyr Val Asp Ile Leu Lys Gln 
    210                 215                 220                 


His Leu Lys Thr Ser Val Arg Lys Leu Lys Leu Gly Arg Lys Trp Val 
225                 230                 235                 240 


Phe Gln His Asp Asn Asp Pro Lys His Thr Ser Lys Val Val Ala Lys 
                245                 250                 255     


Trp Leu Lys Asp Asn Lys Val Lys Val Leu Glu Trp Pro Ser Gln Ser 
            260                 265                 270         


Pro Asp Leu Asn Pro Ile Glu Asn Leu Trp Ala Glu Leu Lys Lys Arg 
        275                 280                 285             


Val Arg Ala Arg Arg Pro Thr Asn Leu Thr Gln Leu His Gln Leu Cys 
    290                 295                 300                 


Gln Glu Glu Trp Ala Lys Ile His Pro Asn Tyr Cys Gly Lys Leu Val 
305                 310                 315                 320 


Glu Gly Tyr Pro Lys Arg Leu Thr Gln Val Lys Gln Phe Lys Gly Asn 
                325                 330                 335     


Ala Thr Lys Tyr 
            340 


<210>  103
<211>  5296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Helraiser transposon

<400>  103
tcctatataa taaaagagaa acatgcaaat tgaccatccc tccgctacgc tcaagccacg       60

cccaccagcc aatcagaagt gactatgcaa attaacccaa caaagatggc agttaaattt      120

gcatacgcag gtgtcaagcg ccccaggagg caacggcggc cgcgggctcc caggaccttc      180

gctggccccg ggaggcgagg ccggccgcgc ctagccacac ccgcgggctc ccgggacctt      240

cgccagcaga gagcagagcg ggagagcggg cggagagcgg gaggtttgga ggacttggca      300

gagcaggagg ccgctggaca tagagcagag cgagagagag ggtggcttgg agggcgtggc      360

tccctctgtc accccagctt cctcatcaca gctgtggaaa ctgacagcag ggaggaggaa      420

gtcccacccc cacagaatca gccagaatca gccgttggtc agacagctct cagcggcctg      480

acagccagga ctctcattca cctgcatctc agaccgtgac agtagagagg tgggactatg      540

tctaaagaac aactgttgat acaacgtagc tctgcagccg aaagatgccg gcgttatcga      600

cagaaaatgt ctgcagagca acgtgcgtct gatcttgaaa gaaggcggcg cctgcaacag      660

aatgtatctg aagagcagct actggaaaaa cgtcgctctg aagccgaaaa acagcggcgt      720

catcgacaga aaatgtctaa agaccaacgt gcctttgaag ttgaaagaag gcggtggcga      780

cgacagaata tgtctagaga acagtcatca acaagtacta ccaataccgg taggaactgc      840

cttctcagca aaaatggagt acatgaggat gcaattctcg aacatagttg tggtggaatg      900

actgttcgat gtgaattttg cctatcacta aatttctctg atgaaaaacc atccgatggg      960

aaatttactc gatgttgtag caaagggaaa gtctgtccaa atgatataca ttttccagat     1020

tacccggcat atttaaaaag attaatgaca aacgaagatt ctgacagtaa aaatttcatg     1080

gaaaatattc gttccataaa tagttctttt gcttttgctt ccatgggtgc aaatattgca     1140

tcgccatcag gatatgggcc atactgtttt agaatacacg gacaagttta tcaccgtact     1200

ggaactttac atccttcgga tggtgtttct cggaagtttg ctcaactcta tattttggat     1260

acagccgaag ctacaagtaa aagattagca atgccagaaa accagggctg ctcagaaaga     1320

ctcatgatca acatcaacaa cctcatgcat gaaataaatg aattaacaaa atcgtacaag     1380

atgctacatg aggtagaaaa ggaagcccaa tctgaagcag cagcaaaagg tattgctccc     1440

acagaagtaa caatggcgat taaatacgat cgtaacagtg acccaggtag atataattct     1500

ccccgtgtaa ccgaggttgc tgtcatattc agaaacgaag atggagaacc tccttttgaa     1560

agggacttgc tcattcattg taaaccagat cccaataatc caaatgccac taaaatgaaa     1620

caaatcagta tcctgtttcc tacattagat gcaatgacat atcctattct ttttccacat     1680

ggtgaaaaag gctggggaac agatattgca ttaagactca gagacaacag tgtaatcgac     1740

aataatacta gacaaaatgt aaggacacga gtcacacaaa tgcagtatta tggatttcat     1800

ctctctgtgc gggacacgtt caatcctatt ttaaatgcag gaaaattaac tcaacagttt     1860

attgtggatt catattcaaa aatggaggcc aatcggataa atttcatcaa agcaaaccaa     1920

tctaagttga gagttgaaaa atatagtggt ttgatggatt atctcaaatc tagatctgaa     1980

aatgacaatg tgccgattgg taaaatgata atacttccat catcttttga gggtagtccc     2040

agaaatatgc agcagcgata tcaggatgct atggcaattg taacgaagta tggcaagccc     2100

gatttattca taaccatgac atgcaacccc aaatgggcag atattacaaa caatttacaa     2160

cgctggcaaa aagttgaaaa cagacctgac ttggtagcca gagtttttaa tattaagctg     2220

aatgctcttt taaatgatat atgtaaattc catttatttg gcaaagtaat agctaaaatt     2280

catgtcattg aatttcagaa acgcggactg cctcacgctc acatattatt gatattagat     2340

agtgagtcca aattacgttc agaagatgac attgaccgta tagttaaggc agaaattcca     2400

gatgaagacc agtgtcctcg actttttcaa attgtaaaat caaatatggt acatggacca     2460

tgtggaatac aaaatccaaa tagtccatgt atggaaaatg gaaaatgttc aaagggatat     2520

ccaaaagaat ttcaaaatgc gaccattgga aatattgatg gatatcccaa atacaaacga     2580

agatctggta gcaccatgtc tattggaaat aaagttgtcg ataacacttg gattgtccct     2640

tataacccgt atttgtgcct taaatataac tgtcatataa atgttgaagt ctgtgcatca     2700

attaaaagtg tcaaatattt atttaaatac atctataaag ggcacgattg tgcaaatatt     2760

caaatttctg aaaaaaatat tatcaatcat gacgaagtac aggacttcat tgactccagg     2820

tatgtgagcg ctcctgaggc tgtttggaga ctttttgcaa tgcgaatgca tgaccaatct     2880

catgcaatca caagattagc tattcatttg ccaaatgatc agaatttgta ttttcatacc     2940

gatgattttg ctgaagtttt agatagggct aaaaggcata actcgacttt gatggcttgg     3000

ttcttattga atagagaaga ttctgatgca cgtaattatt attattggga gattccacag     3060

cattatgtgt ttaataattc tttgtggaca aaacgccgaa agggtgggaa taaagtatta     3120

ggtagactgt tcactgtgag ctttagagaa ccagaacgat attaccttag acttttgctt     3180

ctgcatgtaa aaggtgcgat aagttttgag gatctgcgaa ctgtaggagg tgtaacttat     3240

gatacatttc atgaagctgc taaacaccga ggattattac ttgatgacac tatctggaaa     3300

gatacgattg acgatgcaat catccttaat atgcccaaac aactacggca actttttgca     3360

tatatatgtg tgtttggatg tccttctgct gcagacaaat tatgggatga gaataaatct     3420

cattttattg aagatttctg ttggaaatta caccgaagag aaggtgcctg tgtgaactgt     3480

gaaatgcatg cccttaacga aattcaggag gtattcacat tgcatggaat gaaatgttca     3540

catttcaaac ttccggacta tcctttatta atgaatgcaa atacatgtga tcaattgtac     3600

gagcaacaac aggcagaggt tttgataaat tctctgaatg atgaacagtt ggcagccttt     3660

cagactataa cttcagccat cgaagatcaa actgtacacc ccaaatgctt tttcttggat     3720

ggtccaggtg gtagtggaaa aacatatctg tataaagttt taacacatta tattagaggt     3780

cgtggtggta ctgttttacc cacagcatct acaggaattg ctgcaaattt acttcttggt     3840

ggaagaacct ttcattccca atataaatta ccaattccat taaatgaaac ttcaatttct     3900

agactcgata taaagagtga agttgctaaa accattaaaa aggcccaact tctcattatt     3960

gatgaatgca ccatggcatc cagtcatgct ataaacgcca tagatagatt actaagagaa     4020

attatgaatt tgaatgttgc atttggtggg aaagttctcc ttctcggagg ggattttcga     4080

caatgtctca gtattgtacc acatgctatg cgatcggcca tagtacaaac gagtttaaag     4140

tactgtaatg tttggggatg tttcagaaag ttgtctctta aaacaaatat gagatcagag     4200

gattctgctt atagtgaatg gttagtaaaa cttggagatg gcaaacttga tagcagtttt     4260

catttaggaa tggatattat tgaaatcccc catgaaatga tttgtaacgg atctattatt     4320

gaagctacct ttggaaatag tatatctata gataatatta aaaatatatc taaacgtgca     4380

attctttgtc caaaaaatga gcatgttcaa aaattaaatg aagaaatttt ggatatactt     4440

gatggagatt ttcacacata tttgagtgat gattccattg attcaacaga tgatgctgaa     4500

aaggaaaatt ttcccatcga atttcttaat agtattactc cttcgggaat gccgtgtcat     4560

aaattaaaat tgaaagtggg tgcaatcatc atgctattga gaaatcttaa tagtaaatgg     4620

ggtctttgta atggtactag atttattatc aaaagattac gacctaacat tatcgaagct     4680

gaagtattaa caggatctgc agagggagag gttgttctga ttccaagaat tgatttgtcc     4740

ccatctgaca ctggcctccc atttaaatta attcgaagac agtttcccgt gatgccagca     4800

tttgcgatga ctattaataa atcacaagga caaactctag acagagtagg aatattccta     4860

cctgaacccg ttttcgcaca tggtcagtta tatgttgctt tctctcgagt tcgaagagca     4920

tgtgacgtta aagttaaagt tgtaaatact tcatcacaag ggaaattagt caagcactct     4980

gaaagtgttt ttactcttaa tgtggtatac agggagatat tagaataagt ttaatcactt     5040

tatcagtcat tgtttgcatc aatgttgttt ttatatcatg tttttgttgt ttttatatca     5100

tgtctttgtt gttgttatat catgttgtta ttgtttattt attaataaat ttatgtatta     5160

ttttcatata cattttactc atttcctttc atctctcaca cttctattat agagaaaggg     5220

caaatagcaa tattaaaata tttcctctaa ttaattccct ttcaatgtgc acgaatttcg     5280

tgcaccgggc cactag                                                     5296


<210>  104
<211>  1496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Helitron transposase

<400>  104

Met Ser Lys Glu Gln Leu Leu Ile Gln Arg Ser Ser Ala Ala Glu Arg 
1               5                   10                  15      


Cys Arg Arg Tyr Arg Gln Lys Met Ser Ala Glu Gln Arg Ala Ser Asp 
            20                  25                  30          


Leu Glu Arg Arg Arg Arg Leu Gln Gln Asn Val Ser Glu Glu Gln Leu 
        35                  40                  45              


Leu Glu Lys Arg Arg Ser Glu Ala Glu Lys Gln Arg Arg His Arg Gln 
    50                  55                  60                  


Lys Met Ser Lys Asp Gln Arg Ala Phe Glu Val Glu Arg Arg Arg Trp 
65                  70                  75                  80  


Arg Arg Gln Asn Met Ser Arg Glu Gln Ser Ser Thr Ser Thr Thr Asn 
                85                  90                  95      


Thr Gly Arg Asn Cys Leu Leu Ser Lys Asn Gly Val His Glu Asp Ala 
            100                 105                 110         


Ile Leu Glu His Ser Cys Gly Gly Met Thr Val Arg Cys Glu Phe Cys 
        115                 120                 125             


Leu Ser Leu Asn Phe Ser Asp Glu Lys Pro Ser Asp Gly Lys Phe Thr 
    130                 135                 140                 


Arg Cys Cys Ser Lys Gly Lys Val Cys Pro Asn Asp Ile His Phe Pro 
145                 150                 155                 160 


Asp Tyr Pro Ala Tyr Leu Lys Arg Leu Met Thr Asn Glu Asp Ser Asp 
                165                 170                 175     


Ser Lys Asn Phe Met Glu Asn Ile Arg Ser Ile Asn Ser Ser Phe Ala 
            180                 185                 190         


Phe Ala Ser Met Gly Ala Asn Ile Ala Ser Pro Ser Gly Tyr Gly Pro 
        195                 200                 205             


Tyr Cys Phe Arg Ile His Gly Gln Val Tyr His Arg Thr Gly Thr Leu 
    210                 215                 220                 


His Pro Ser Asp Gly Val Ser Arg Lys Phe Ala Gln Leu Tyr Ile Leu 
225                 230                 235                 240 


Asp Thr Ala Glu Ala Thr Ser Lys Arg Leu Ala Met Pro Glu Asn Gln 
                245                 250                 255     


Gly Cys Ser Glu Arg Leu Met Ile Asn Ile Asn Asn Leu Met His Glu 
            260                 265                 270         


Ile Asn Glu Leu Thr Lys Ser Tyr Lys Met Leu His Glu Val Glu Lys 
        275                 280                 285             


Glu Ala Gln Ser Glu Ala Ala Ala Lys Gly Ile Ala Pro Thr Glu Val 
    290                 295                 300                 


Thr Met Ala Ile Lys Tyr Asp Arg Asn Ser Asp Pro Gly Arg Tyr Asn 
305                 310                 315                 320 


Ser Pro Arg Val Thr Glu Val Ala Val Ile Phe Arg Asn Glu Asp Gly 
                325                 330                 335     


Glu Pro Pro Phe Glu Arg Asp Leu Leu Ile His Cys Lys Pro Asp Pro 
            340                 345                 350         


Asn Asn Pro Asn Ala Thr Lys Met Lys Gln Ile Ser Ile Leu Phe Pro 
        355                 360                 365             


Thr Leu Asp Ala Met Thr Tyr Pro Ile Leu Phe Pro His Gly Glu Lys 
    370                 375                 380                 


Gly Trp Gly Thr Asp Ile Ala Leu Arg Leu Arg Asp Asn Ser Val Ile 
385                 390                 395                 400 


Asp Asn Asn Thr Arg Gln Asn Val Arg Thr Arg Val Thr Gln Met Gln 
                405                 410                 415     


Tyr Tyr Gly Phe His Leu Ser Val Arg Asp Thr Phe Asn Pro Ile Leu 
            420                 425                 430         


Asn Ala Gly Lys Leu Thr Gln Gln Phe Ile Val Asp Ser Tyr Ser Lys 
        435                 440                 445             


Met Glu Ala Asn Arg Ile Asn Phe Ile Lys Ala Asn Gln Ser Lys Leu 
    450                 455                 460                 


Arg Val Glu Lys Tyr Ser Gly Leu Met Asp Tyr Leu Lys Ser Arg Ser 
465                 470                 475                 480 


Glu Asn Asp Asn Val Pro Ile Gly Lys Met Ile Ile Leu Pro Ser Ser 
                485                 490                 495     


Phe Glu Gly Ser Pro Arg Asn Met Gln Gln Arg Tyr Gln Asp Ala Met 
            500                 505                 510         


Ala Ile Val Thr Lys Tyr Gly Lys Pro Asp Leu Phe Ile Thr Met Thr 
        515                 520                 525             


Cys Asn Pro Lys Trp Ala Asp Ile Thr Asn Asn Leu Gln Arg Trp Gln 
    530                 535                 540                 


Lys Val Glu Asn Arg Pro Asp Leu Val Ala Arg Val Phe Asn Ile Lys 
545                 550                 555                 560 


Leu Asn Ala Leu Leu Asn Asp Ile Cys Lys Phe His Leu Phe Gly Lys 
                565                 570                 575     


Val Ile Ala Lys Ile His Val Ile Glu Phe Gln Lys Arg Gly Leu Pro 
            580                 585                 590         


His Ala His Ile Leu Leu Ile Leu Asp Ser Glu Ser Lys Leu Arg Ser 
        595                 600                 605             


Glu Asp Asp Ile Asp Arg Ile Val Lys Ala Glu Ile Pro Asp Glu Asp 
    610                 615                 620                 


Gln Cys Pro Arg Leu Phe Gln Ile Val Lys Ser Asn Met Val His Gly 
625                 630                 635                 640 


Pro Cys Gly Ile Gln Asn Pro Asn Ser Pro Cys Met Glu Asn Gly Lys 
                645                 650                 655     


Cys Ser Lys Gly Tyr Pro Lys Glu Phe Gln Asn Ala Thr Ile Gly Asn 
            660                 665                 670         


Ile Asp Gly Tyr Pro Lys Tyr Lys Arg Arg Ser Gly Ser Thr Met Ser 
        675                 680                 685             


Ile Gly Asn Lys Val Val Asp Asn Thr Trp Ile Val Pro Tyr Asn Pro 
    690                 695                 700                 


Tyr Leu Cys Leu Lys Tyr Asn Cys His Ile Asn Val Glu Val Cys Ala 
705                 710                 715                 720 


Ser Ile Lys Ser Val Lys Tyr Leu Phe Lys Tyr Ile Tyr Lys Gly His 
                725                 730                 735     


Asp Cys Ala Asn Ile Gln Ile Ser Glu Lys Asn Ile Ile Asn His Asp 
            740                 745                 750         


Glu Val Gln Asp Phe Ile Asp Ser Arg Tyr Val Ser Ala Pro Glu Ala 
        755                 760                 765             


Val Trp Arg Leu Phe Ala Met Arg Met His Asp Gln Ser His Ala Ile 
    770                 775                 780                 


Thr Arg Leu Ala Ile His Leu Pro Asn Asp Gln Asn Leu Tyr Phe His 
785                 790                 795                 800 


Thr Asp Asp Phe Ala Glu Val Leu Asp Arg Ala Lys Arg His Asn Ser 
                805                 810                 815     


Thr Leu Met Ala Trp Phe Leu Leu Asn Arg Glu Asp Ser Asp Ala Arg 
            820                 825                 830         


Asn Tyr Tyr Tyr Trp Glu Ile Pro Gln His Tyr Val Phe Asn Asn Ser 
        835                 840                 845             


Leu Trp Thr Lys Arg Arg Lys Gly Gly Asn Lys Val Leu Gly Arg Leu 
    850                 855                 860                 


Phe Thr Val Ser Phe Arg Glu Pro Glu Arg Tyr Tyr Leu Arg Leu Leu 
865                 870                 875                 880 


Leu Leu His Val Lys Gly Ala Ile Ser Phe Glu Asp Leu Arg Thr Val 
                885                 890                 895     


Gly Gly Val Thr Tyr Asp Thr Phe His Glu Ala Ala Lys His Arg Gly 
            900                 905                 910         


Leu Leu Leu Asp Asp Thr Ile Trp Lys Asp Thr Ile Asp Asp Ala Ile 
        915                 920                 925             


Ile Leu Asn Met Pro Lys Gln Leu Arg Gln Leu Phe Ala Tyr Ile Cys 
    930                 935                 940                 


Val Phe Gly Cys Pro Ser Ala Ala Asp Lys Leu Trp Asp Glu Asn Lys 
945                 950                 955                 960 


Ser His Phe Ile Glu Asp Phe Cys Trp Lys Leu His Arg Arg Glu Gly 
                965                 970                 975     


Ala Cys Val Asn Cys Glu Met His Ala Leu Asn Glu Ile Gln Glu Val 
            980                 985                 990         


Phe Thr Leu His Gly Met Lys Cys  Ser His Phe Lys Leu  Pro Asp Tyr 
        995                 1000                 1005             


Pro Leu  Leu Met Asn Ala Asn  Thr Cys Asp Gln Leu  Tyr Glu Gln 
    1010                 1015                 1020             


Gln Gln  Ala Glu Val Leu Ile  Asn Ser Leu Asn Asp  Glu Gln Leu 
    1025                 1030                 1035             


Ala Ala  Phe Gln Thr Ile Thr  Ser Ala Ile Glu Asp  Gln Thr Val 
    1040                 1045                 1050             


His Pro  Lys Cys Phe Phe Leu  Asp Gly Pro Gly Gly  Ser Gly Lys 
    1055                 1060                 1065             


Thr Tyr  Leu Tyr Lys Val Leu  Thr His Tyr Ile Arg  Gly Arg Gly 
    1070                 1075                 1080             


Gly Thr  Val Leu Pro Thr Ala  Ser Thr Gly Ile Ala  Ala Asn Leu 
    1085                 1090                 1095             


Leu Leu  Gly Gly Arg Thr Phe  His Ser Gln Tyr Lys  Leu Pro Ile 
    1100                 1105                 1110             


Pro Leu  Asn Glu Thr Ser Ile  Ser Arg Leu Asp Ile  Lys Ser Glu 
    1115                 1120                 1125             


Val Ala  Lys Thr Ile Lys Lys  Ala Gln Leu Leu Ile  Ile Asp Glu 
    1130                 1135                 1140             


Cys Thr  Met Ala Ser Ser His  Ala Ile Asn Ala Ile  Asp Arg Leu 
    1145                 1150                 1155             


Leu Arg  Glu Ile Met Asn Leu  Asn Val Ala Phe Gly  Gly Lys Val 
    1160                 1165                 1170             


Leu Leu  Leu Gly Gly Asp Phe  Arg Gln Cys Leu Ser  Ile Val Pro 
    1175                 1180                 1185             


His Ala  Met Arg Ser Ala Ile  Val Gln Thr Ser Leu  Lys Tyr Cys 
    1190                 1195                 1200             


Asn Val  Trp Gly Cys Phe Arg  Lys Leu Ser Leu Lys  Thr Asn Met 
    1205                 1210                 1215             


Arg Ser  Glu Asp Ser Ala Tyr  Ser Glu Trp Leu Val  Lys Leu Gly 
    1220                 1225                 1230             


Asp Gly  Lys Leu Asp Ser Ser  Phe His Leu Gly Met  Asp Ile Ile 
    1235                 1240                 1245             


Glu Ile  Pro His Glu Met Ile  Cys Asn Gly Ser Ile  Ile Glu Ala 
    1250                 1255                 1260             


Thr Phe  Gly Asn Ser Ile Ser  Ile Asp Asn Ile Lys  Asn Ile Ser 
    1265                 1270                 1275             


Lys Arg  Ala Ile Leu Cys Pro  Lys Asn Glu His Val  Gln Lys Leu 
    1280                 1285                 1290             


Asn Glu  Glu Ile Leu Asp Ile  Leu Asp Gly Asp Phe  His Thr Tyr 
    1295                 1300                 1305             


Leu Ser  Asp Asp Ser Ile Asp  Ser Thr Asp Asp Ala  Glu Lys Glu 
    1310                 1315                 1320             


Asn Phe  Pro Ile Glu Phe Leu  Asn Ser Ile Thr Pro  Ser Gly Met 
    1325                 1330                 1335             


Pro Cys  His Lys Leu Lys Leu  Lys Val Gly Ala Ile  Ile Met Leu 
    1340                 1345                 1350             


Leu Arg  Asn Leu Asn Ser Lys  Trp Gly Leu Cys Asn  Gly Thr Arg 
    1355                 1360                 1365             


Phe Ile  Ile Lys Arg Leu Arg  Pro Asn Ile Ile Glu  Ala Glu Val 
    1370                 1375                 1380             


Leu Thr  Gly Ser Ala Glu Gly  Glu Val Val Leu Ile  Pro Arg Ile 
    1385                 1390                 1395             


Asp Leu  Ser Pro Ser Asp Thr  Gly Leu Pro Phe Lys  Leu Ile Arg 
    1400                 1405                 1410             


Arg Gln  Phe Pro Val Met Pro  Ala Phe Ala Met Thr  Ile Asn Lys 
    1415                 1420                 1425             


Ser Gln  Gly Gln Thr Leu Asp  Arg Val Gly Ile Phe  Leu Pro Glu 
    1430                 1435                 1440             


Pro Val  Phe Ala His Gly Gln  Leu Tyr Val Ala Phe  Ser Arg Val 
    1445                 1450                 1455             


Arg Arg  Ala Cys Asp Val Lys  Val Lys Val Val Asn  Thr Ser Ser 
    1460                 1465                 1470             


Gln Gly  Lys Leu Val Lys His  Ser Glu Ser Val Phe  Thr Leu Asn 
    1475                 1480                 1485             


Val Val  Tyr Arg Glu Ile Leu  Glu 
    1490                 1495     


<210>  105
<211>  4682
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tol2 transposase

<400>  105
cagaggtgta aagtacttga gtaattttac ttgattactg tacttaagta ttatttttgg       60

ggatttttac tttacttgag tacaattaaa aatcaatact tttactttta cttaattaca      120

tttttttaga aaaaaaagta ctttttactc cttacaattt tatttacagt caaaaagtac      180

ttattttttg gagatcactt cattctattt tcccttgcta ttaccaaacc aattgaattg      240

cgctgatgcc cagtttaatt taaatgttat ttattctgcc tatgaaaatc gttttcacat      300

tatatgaaat tggtcagaca tgttcattgg tcctttggaa gtgacgtcat gtcacatcta      360

ttaccacaat gcacagcacc ttgacctgga aattagggaa attataacag tcaatcagtg      420

gaagaaaatg gaggaagtat gtgattcatc agcagctgcg agcagcacag tccaaaatca      480

gccacaggat caagagcacc cgtggccgta tcttcgcgaa ttcttttctt taagtggtgt      540

aaataaagat tcattcaaga tgaaatgtgt cctctgtctc ccgcttaata aagaaatatc      600

ggccttcaaa agttcgccat caaacctaag gaagcatatt gaggtaagta cattaagtat      660

tttgttttac tgatagtttt tttttttttt tttttttttt tttttgggtg tgcatgtttt      720

gacgttgatg gcgcgccttt tatatgtgta gtaggcctat tttcactaat gcatgcgatt      780

gacaatataa ggctcacgta ataaaatgct aaaatgcatt tgtaattggt aacgttaggt      840

ccacgggaaa tttggcgcct attgcagctt tgaataatca ttatcattcc gtgctctcat      900

tgtgtttgaa ttcatgcaaa acacaagaaa accaagcgag aaattttttt ccaaacatgt      960

tgtattgtca aaacggtaac actttacaat gaggttgatt agttcatgta ttaactaaca     1020

ttaaataacc atgagcaata catttgttac tgtatctgtt aatctttgtt aacgttagtt     1080

aatagaaata cagatgttca ttgtttgttc atgttagttc acagtgcatt aactaatgtt     1140

aacaagatat aaagtattag taaatgttga aattaacatg tatacgtgca gttcattatt     1200

agttcatgtt aactaatgta gttaactaac gaaccttatt gtaaaagtgt taccatcaaa     1260

actaatgtaa tgaaatcaat tcaccctgtc atgtcagcct tacagtcctg tgtttttgtc     1320

aatataatca gaaataaaat taatgtttga ttgtcactaa atgctactgt atttctaaaa     1380

tcaacaagta tttaacatta taaagtgtgc aattggctgc aaatgtcagt tttattaaag     1440

ggttagttca cccaaaaatg aaaataatgt cattaatgac tcgccctcat gtcgttccaa     1500

gcccgtaaga cctccgttca tcttcagaac acagtttaag atattttaga tttagtccga     1560

gagctttctg tgcctccatt gagaatgtat gtacggtata ctgtccatgt ccagaaaggt     1620

aataaaaaca tcaaagtagt ccatgtgaca tcagtgggtt agttagaatt ttttgaagca     1680

tcgaatacat tttggtccaa aaataacaaa acctacgact ttattcggca ttgtattctc     1740

ttccgggtct gttgtcaatc cgcgttcacg acttcgcagt gacgctacaa tgctgaataa     1800

agtcgtaggt tttgttattt ttggaccaaa atgtattttc gatgcttcaa ataattctac     1860

ctaacccact gatgtcacat ggactacttt gatgttttta ttacctttct ggacatggac     1920

agtataccgt acatacattt tcagtggagg gacagaaagc tctcggacta aatctaaaat     1980

atcttaaact gtgttccgaa gatgaacgga ggtgttacgg gcttggaacg acatgagggt     2040

gagtcattaa tgacatcttt tcatttttgg gtgaactaac cctttaatgc tgtaatcaga     2100

gagtgtatgt gtaattgtta catttattgc atacaatata aatatttatt tgttgttttt     2160

acagagaatg cacccaaatt acctcaaaaa ctactctaaa ttgacagcac agaagagaaa     2220

gatcgggacc tccacccatg cttccagcag taagcaactg aaagttgact cagttttccc     2280

agtcaaacat gtgtctccag tcactgtgaa caaagctata ttaaggtaca tcattcaagg     2340

acttcatcct ttcagcactg ttgatctgcc atcatttaaa gagctgatta gtacactgca     2400

gcctggcatt tctgtcatta caaggcctac tttacgctcc aagatagctg aagctgctct     2460

gatcatgaaa cagaaagtga ctgctgccat gagtgaagtt gaatggattg caaccacaac     2520

ggattgttgg actgcacgta gaaagtcatt cattggtgta actgctcact ggatcaaccc     2580

tggaagtctt gaaagacatt ccgctgcact tgcctgcaaa agattaatgg gctctcatac     2640

ttttgaggta ctggccagtg ccatgaatga tatccactca gagtatgaaa tacgtgacaa     2700

ggttgtttgc acaaccacag acagtggttc caactttatg aaggctttca gagtttttgg     2760

tgtggaaaac aatgatatcg agactgaggc aagaaggtgt gaaagtgatg acactgattc     2820

tgaaggctgt ggtgagggaa gtgatggtgt ggaattccaa gatgcctcac gagtcctgga     2880

ccaagacgat ggcttcgaat tccagctacc aaaacatcaa aagtgtgcct gtcacttact     2940

taacctagtc tcaagcgttg atgcccaaaa agctctctca aatgaacact acaagaaact     3000

ctacagatct gtctttggca aatgccaagc tttatggaat aaaagcagcc gatcggctct     3060

agcagctgaa gctgttgaat cagaaagccg gcttcagctt ttaaggccaa accaaacgcg     3120

gtggaattca acttttatgg ctgttgacag aattcttcaa atttgcaaag aagcaggaga     3180

aggcgcactt cggaatatat gcacctctct tgaggttcca atgtaagtgt ttttcccctc     3240

tatcgatgta aacaaatgtg ggttgttttt gtttaatact ctttgattat gctgatttct     3300

cctgtaggtt taatccagca gaaatgctgt tcttgacaga gtgggccaac acaatgcgtc     3360

cagttgcaaa agtactcgac atcttgcaag cggaaacgaa tacacagctg gggtggctgc     3420

tgcctagtgt ccatcagtta agcttgaaac ttcagcgact ccaccattct ctcaggtact     3480

gtgacccact tgtggatgcc ctacaacaag gaatccaaac acgattcaag catatgtttg     3540

aagatcctga gatcatagca gctgccatcc ttctccctaa atttcggacc tcttggacaa     3600

atgatgaaac catcataaaa cgaggtaaat gaatgcaagc aacatacact tgacgaattc     3660

taatctgggc aacctttgag ccataccaaa attattcttt tatttattta tttttgcact     3720

ttttaggaat gttatatccc atctttggct gtgatctcaa tatgaatatt gatgtaaagt     3780

attcttgcag caggttgtag ttatccctca gtgtttcttg aaaccaaact catatgtatc     3840

atatgtggtt tggaaatgca gttagatttt atgctaaaat aagggatttg catgatttta     3900

gatgtagatg actgcacgta aatgtagtta atgacaaaat ccataaaatt tgttcccagt     3960

cagaagcccc tcaaccaaac ttttctttgt gtctgctcac tgtgcttgta ggcatggact     4020

acatcagagt gcatctggag cctttggacc acaagaagga attggccaac agttcatctg     4080

atgatgaaga ttttttcgct tctttgaaac cgacaacaca tgaagccagc aaagagttgg     4140

atggatatct ggcctgtgtt tcagacacca gggagtctct gctcacgttt cctgctattt     4200

gcagcctctc tatcaagact aatacacctc ttcccgcatc ggctgcctgt gagaggcttt     4260

tcagcactgc aggattgctt ttcagcccca aaagagctag gcttgacact aacaattttg     4320

agaatcagct tctactgaag ttaaatctga ggttttacaa ctttgagtag cgtgtactgg     4380

cattagattg tctgtcttat agtttgataa ttaaatacaa acagttctaa agcaggataa     4440

aaccttgtat gcatttcatt taatgttttt tgagattaaa agcttaaaca agaatctcta     4500

gttttctttc ttgcttttac ttttacttcc ttaatactca agtacaattt taatggagta     4560

cttttttact tttactcaag taagattcta gccagatact tttactttta attgagtaaa     4620

attttcccta agtacttgta ctttcacttg agtaaaattt ttgagtactt tttacacctc     4680

tg                                                                    4682


<210>  106
<211>  649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tol2 transposase

<400>  106

Met Glu Glu Val Cys Asp Ser Ser Ala Ala Ala Ser Ser Thr Val Gln 
1               5                   10                  15      


Asn Gln Pro Gln Asp Gln Glu His Pro Trp Pro Tyr Leu Arg Glu Phe 
            20                  25                  30          


Phe Ser Leu Ser Gly Val Asn Lys Asp Ser Phe Lys Met Lys Cys Val 
        35                  40                  45              


Leu Cys Leu Pro Leu Asn Lys Glu Ile Ser Ala Phe Lys Ser Ser Pro 
    50                  55                  60                  


Ser Asn Leu Arg Lys His Ile Glu Arg Met His Pro Asn Tyr Leu Lys 
65                  70                  75                  80  


Asn Tyr Ser Lys Leu Thr Ala Gln Lys Arg Lys Ile Gly Thr Ser Thr 
                85                  90                  95      


His Ala Ser Ser Ser Lys Gln Leu Lys Val Asp Ser Val Phe Pro Val 
            100                 105                 110         


Lys His Val Ser Pro Val Thr Val Asn Lys Ala Ile Leu Arg Tyr Ile 
        115                 120                 125             


Ile Gln Gly Leu His Pro Phe Ser Thr Val Asp Leu Pro Ser Phe Lys 
    130                 135                 140                 


Glu Leu Ile Ser Thr Leu Gln Pro Gly Ile Ser Val Ile Thr Arg Pro 
145                 150                 155                 160 


Thr Leu Arg Ser Lys Ile Ala Glu Ala Ala Leu Ile Met Lys Gln Lys 
                165                 170                 175     


Val Thr Ala Ala Met Ser Glu Val Glu Trp Ile Ala Thr Thr Thr Asp 
            180                 185                 190         


Cys Trp Thr Ala Arg Arg Lys Ser Phe Ile Gly Val Thr Ala His Trp 
        195                 200                 205             


Ile Asn Pro Gly Ser Leu Glu Arg His Ser Ala Ala Leu Ala Cys Lys 
    210                 215                 220                 


Arg Leu Met Gly Ser His Thr Phe Glu Val Leu Ala Ser Ala Met Asn 
225                 230                 235                 240 


Asp Ile His Ser Glu Tyr Glu Ile Arg Asp Lys Val Val Cys Thr Thr 
                245                 250                 255     


Thr Asp Ser Gly Ser Asn Phe Met Lys Ala Phe Arg Val Phe Gly Val 
            260                 265                 270         


Glu Asn Asn Asp Ile Glu Thr Glu Ala Arg Arg Cys Glu Ser Asp Asp 
        275                 280                 285             


Thr Asp Ser Glu Gly Cys Gly Glu Gly Ser Asp Gly Val Glu Phe Gln 
    290                 295                 300                 


Asp Ala Ser Arg Val Leu Asp Gln Asp Asp Gly Phe Glu Phe Gln Leu 
305                 310                 315                 320 


Pro Lys His Gln Lys Cys Ala Cys His Leu Leu Asn Leu Val Ser Ser 
                325                 330                 335     


Val Asp Ala Gln Lys Ala Leu Ser Asn Glu His Tyr Lys Lys Leu Tyr 
            340                 345                 350         


Arg Ser Val Phe Gly Lys Cys Gln Ala Leu Trp Asn Lys Ser Ser Arg 
        355                 360                 365             


Ser Ala Leu Ala Ala Glu Ala Val Glu Ser Glu Ser Arg Leu Gln Leu 
    370                 375                 380                 


Leu Arg Pro Asn Gln Thr Arg Trp Asn Ser Thr Phe Met Ala Val Asp 
385                 390                 395                 400 


Arg Ile Leu Gln Ile Cys Lys Glu Ala Gly Glu Gly Ala Leu Arg Asn 
                405                 410                 415     


Ile Cys Thr Ser Leu Glu Val Pro Met Phe Asn Pro Ala Glu Met Leu 
            420                 425                 430         


Phe Leu Thr Glu Trp Ala Asn Thr Met Arg Pro Val Ala Lys Val Leu 
        435                 440                 445             


Asp Ile Leu Gln Ala Glu Thr Asn Thr Gln Leu Gly Trp Leu Leu Pro 
    450                 455                 460                 


Ser Val His Gln Leu Ser Leu Lys Leu Gln Arg Leu His His Ser Leu 
465                 470                 475                 480 


Arg Tyr Cys Asp Pro Leu Val Asp Ala Leu Gln Gln Gly Ile Gln Thr 
                485                 490                 495     


Arg Phe Lys His Met Phe Glu Asp Pro Glu Ile Ile Ala Ala Ala Ile 
            500                 505                 510         


Leu Leu Pro Lys Phe Arg Thr Ser Trp Thr Asn Asp Glu Thr Ile Ile 
        515                 520                 525             


Lys Arg Gly Met Asp Tyr Ile Arg Val His Leu Glu Pro Leu Asp His 
    530                 535                 540                 


Lys Lys Glu Leu Ala Asn Ser Ser Ser Asp Asp Glu Asp Phe Phe Ala 
545                 550                 555                 560 


Ser Leu Lys Pro Thr Thr His Glu Ala Ser Lys Glu Leu Asp Gly Tyr 
                565                 570                 575     


Leu Ala Cys Val Ser Asp Thr Arg Glu Ser Leu Leu Thr Phe Pro Ala 
            580                 585                 590         


Ile Cys Ser Leu Ser Ile Lys Thr Asn Thr Pro Leu Pro Ala Ser Ala 
        595                 600                 605             


Ala Cys Glu Arg Leu Phe Ser Thr Ala Gly Leu Leu Phe Ser Pro Lys 
    610                 615                 620                 


Arg Ala Arg Leu Asp Thr Asn Asn Phe Glu Asn Gln Leu Leu Leu Lys 
625                 630                 635                 640 


Leu Asn Leu Arg Phe Tyr Asn Phe Glu 
                645                 


<210>  107
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TcBuster transposase

<400>  107

Met Met Leu Asn Trp Leu Lys Ser Gly Lys Leu Glu Ser Gln Ser Gln 
1               5                   10                  15      


Glu Gln Ser Ser Cys Tyr Leu Glu Asn Ser Asn Cys Leu Pro Pro Thr 
            20                  25                  30          


Leu Asp Ser Thr Asp Ile Ile Gly Glu Glu Asn Lys Ala Gly Thr Thr 
        35                  40                  45              


Ser Arg Lys Lys Arg Lys Tyr Asp Glu Asp Tyr Leu Asn Phe Gly Phe 
    50                  55                  60                  


Thr Trp Thr Gly Asp Lys Asp Glu Pro Asn Gly Leu Cys Val Ile Cys 
65                  70                  75                  80  


Glu Gln Val Val Asn Asn Ser Ser Leu Asn Pro Ala Lys Leu Lys Arg 
                85                  90                  95      


His Leu Asp Thr Lys His Pro Thr Leu Lys Gly Lys Ser Glu Tyr Phe 
            100                 105                 110         


Lys Arg Lys Cys Asn Glu Leu Asn Gln Lys Lys His Thr Phe Glu Arg 
        115                 120                 125             


Tyr Val Arg Asp Asp Asn Lys Asn Leu Leu Lys Ala Ser Tyr Leu Val 
    130                 135                 140                 


Ser Leu Arg Ile Ala Lys Gln Gly Glu Ala Tyr Thr Ile Ala Glu Lys 
145                 150                 155                 160 


Leu Ile Lys Pro Cys Thr Lys Asp Leu Thr Thr Cys Val Phe Gly Glu 
                165                 170                 175     


Lys Phe Ala Ser Lys Val Asp Leu Val Pro Leu Ser Asp Thr Thr Ile 
            180                 185                 190         


Ser Arg Arg Ile Glu Asp Met Ser Tyr Phe Cys Glu Ala Val Leu Val 
        195                 200                 205             


Asn Arg Leu Glu Asn Ala Lys Cys Gly Phe Thr Leu Gln Met Asp Glu 
    210                 215                 220                 


Ser Thr Asp Val Ala Gly Leu Ala Ile Leu Leu Val Phe Val Arg Tyr 
225                 230                 235                 240 


Ile His Glu Ser Ser Phe Glu Glu Asp Met Leu Phe Cys Lys Ala Leu 
                245                 250                 255     


Pro Thr Gln Thr Thr Gly Glu Glu Ile Phe Asn Leu Leu Asn Ala Tyr 
            260                 265                 270         


Phe Glu Lys His Ser Ile Pro Trp Asn Leu Cys Tyr His Ile Cys Thr 
        275                 280                 285             


Asp Gly Ala Lys Ala Met Val Gly Val Ile Lys Gly Val Ile Ala Arg 
    290                 295                 300                 


Ile Lys Lys Leu Val Pro Asp Ile Lys Ala Ser His Cys Cys Leu His 
305                 310                 315                 320 


Arg His Ala Leu Ala Val Lys Arg Ile Pro Asn Ala Leu His Glu Val 
                325                 330                 335     


Leu Asn Asp Ala Val Lys Met Ile Asn Phe Ile Lys Ser Arg Pro Leu 
            340                 345                 350         


Asn Ala Arg Val Phe Ala Leu Leu Cys Asp Asp Leu Gly Ser Leu His 
        355                 360                 365             


Lys Asn Leu Leu Leu His Thr Glu Val Arg Trp Leu Ser Arg Gly Lys 
    370                 375                 380                 


Val Leu Thr Arg Phe Trp Glu Leu Arg Asp Glu Ile Arg Ile Phe Phe 
385                 390                 395                 400 


Asn Glu Arg Glu Phe Ala Gly Lys Leu Asn Asp Thr Ser Trp Leu Gln 
                405                 410                 415     


Asn Leu Ala Tyr Ile Ala Asp Ile Phe Ser Tyr Leu Asn Glu Val Asn 
            420                 425                 430         


Leu Ser Leu Gln Gly Pro Asn Ser Thr Ile Phe Lys Val Asn Ser Arg 
        435                 440                 445             


Ile Asn Ser Ile Lys Ser Lys Leu Lys Leu Trp Glu Glu Cys Ile Thr 
    450                 455                 460                 


Lys Asn Asn Thr Glu Cys Phe Ala Asn Leu Asn Asp Phe Leu Glu Thr 
465                 470                 475                 480 


Ser Asn Thr Ala Leu Asp Pro Asn Leu Lys Ser Asn Ile Leu Glu His 
                485                 490                 495     


Leu Asn Gly Leu Lys Asn Thr Phe Leu Glu Tyr Phe Pro Pro Thr Cys 
            500                 505                 510         


Asn Asn Ile Ser Trp Val Glu Asn Pro Phe Asn Glu Cys Gly Asn Val 
        515                 520                 525             


Asp Thr Leu Pro Ile Lys Glu Arg Glu Gln Leu Ile Asp Ile Arg Thr 
    530                 535                 540                 


Asp Thr Thr Leu Lys Ser Ser Phe Val Pro Asp Gly Ile Gly Pro Phe 
545                 550                 555                 560 


Trp Ile Lys Leu Met Asp Glu Phe Pro Glu Ile Ser Lys Arg Ala Val 
                565                 570                 575     


Lys Glu Leu Met Pro Phe Val Thr Thr Tyr Leu Cys Glu Lys Ser Phe 
            580                 585                 590         


Ser Val Tyr Val Ala Thr Lys Thr Lys Tyr Arg Asn Arg Leu Asp Ala 
        595                 600                 605             


Glu Asp Asp Met Arg Leu Gln Leu Thr Thr Ile His Pro Asp Ile Asp 
    610                 615                 620                 


Asn Leu Cys Asn Asn Lys Gln Ala Gln Lys Ser His 
625                 630                 635     


<210>  108
<211>  1911
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TcBuster transposase

<400>  108
atgatgttga attggctgaa aagtggaaag cttgaaagtc aatcacagga acagagttcc       60

tgctaccttg agaactctaa ctgcctgcca ccaacgctcg attctacaga tattatcggt      120

gaagagaaca aagctggtac cacctctcgc aagaagcgga aatatgacga ggactatctg      180

aacttcggtt ttacatggac tggcgacaag gatgagccca acggactttg tgtgatttgc      240

gagcaggtag tcaacaattc ctcacttaac ccggccaaac tgaaacgcca tttggacaca      300

aagcatccga cgcttaaagg caagagcgaa tacttcaaaa gaaaatgtaa cgagctcaat      360

caaaagaagc atacttttga gcgatacgta agggacgata acaagaacct cctgaaagct      420

tcttatctcg tcagtttgag aatagctaaa cagggcgagg catataccat agcggagaag      480

ttgatcaagc cttgcaccaa ggatctgaca acttgcgtat ttggagaaaa attcgcgagc      540

aaagttgatc tcgtccccct gtccgacacg actatttcaa ggcgaatcga agacatgagt      600

tacttctgtg aagccgtgct ggtgaacagg ttgaaaaatg ctaaatgtgg gtttacgctg      660

cagatggacg agtcaacaga tgttgccggt cttgcaatcc tgcttgtgtt tgttaggtac      720

atacatgaaa gctcttttga ggaggatatg ttgttctgca aagcacttcc cactcagacg      780

acaggggagg agattttcaa tcttctcaat gcctatttcg aaaagcactc catcccatgg      840

aatctgtgtt accacatttg cacagacggt gccaaggcaa tggtaggagt tattaaagga      900

gtcatagcga gaataaaaaa actcgtccct gatataaaag ctagccactg ttgcctgcat      960

cgccacgctt tggctgtaaa gcgaataccg aatgcattgc acgaggtgct caatgacgct     1020

gttaaaatga tcaacttcat caagtctcgg ccgttgaatg cgcgcgtctt cgctttgctg     1080

tgtgacgatt tggggagcct gcataaaaat cttcttcttc ataccgaagt gaggtggctg     1140

tctagaggaa aggtgctgac ccgattttgg gaactgagag atgaaattag aattttcttc     1200

aacgaaaggg aatttgccgg gaaattgaac gacaccagtt ggttgcaaaa tttggcatat     1260

atagctgaca tattcagtta tctgaatgaa gttaatcttt ccctgcaagg gccgaatagc     1320

acaatcttca aggtaaatag ccgcattaac agtattaaat caaagttgaa gttgtgggaa     1380

gagtgtataa cgaaaaataa cactgagtgt tttgcgaacc tcaacgattt tttggaaact     1440

tcaaacactg cgttggatcc aaacctgaag tctaatattt tggaacatct caacggtctt     1500

aagaacacct ttctggagta ttttccacct acgtgtaata atatctcctg ggtggagaat     1560

cctttcaatg aatgcggtaa cgtcgataca ctcccaataa aagagaggga acaattgatt     1620

gacatacgga ctgatacgac attgaaatct tcattcgtgc ctgatggtat aggaccattc     1680

tggatcaaac tgatggacga atttccagaa attagcaaac gagctgtcaa agagctcatg     1740

ccatttgtaa ccacttacct ctgtgagaaa tcattttccg tctatgtagc cacaaaaaca     1800

aaatatcgaa atagacttga tgctgaagac gatatgcgac tccaacttac tactatccat     1860

ccagacattg acaacctttg taacaacaag caggctcaga aatcccactg a              1911


<210>  109
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   FKBP12 polypeptide

<400>  109

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  110
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FKBP12 polynucleotide

<400>  110
ggggtccagg tcgagactat ttcaccaggg gatgggcgaa catttccaaa aaggggccag       60

acttgcgtcg tgcattacac cgggatgctg gaggacggga agaaagtgga cagctccagg      120

gatcgcaaca agcccttcaa gttcatgctg ggaaagcagg aagtgatccg aggatgggag      180

gaaggcgtgg cacagatgtc agtcggccag cgggccaaac tgaccattag ccctgactac      240

gcttatggag caacaggcca cccagggatc attccccctc atgccaccct ggtcttcgat      300

gtggaactgc tgaagctgga g                                                321


<210>  111
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  111

Gly Gly Gly Gly Ser 
1               5   


<210>  112
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  112
ggaggaggag gatcc                                                        15


<210>  113
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated caspase 9 polypeptide

<400>  113

Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp 
1               5                   10                  15      


Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile 
            20                  25                  30          


Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly 
        35                  40                  45              


Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His 
    50                  55                  60                  


Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu 
65                  70                  75                  80  


Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys 
                85                  90                  95      


Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe 
            100                 105                 110         


Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys 
        115                 120                 125             


Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys 
    130                 135                 140                 


Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His 
145                 150                 155                 160 


Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser 
                165                 170                 175     


Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe 
            180                 185                 190         


Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe 
        195                 200                 205             


Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys 
    210                 215                 220                 


Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp 
225                 230                 235                 240 


Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala 
                245                 250                 255     


Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe 
            260                 265                 270         


Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
        275                 280         


<210>  114
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated caspase 9 polynucleotide

<400>  114
tttggggacg tgggggccct ggagtctctg cgaggaaatg ccgatctggc ttacatcctg       60

agcatggaac cctgcggcca ctgtctgatc attaacaatg tgaacttctg cagagaaagc      120

ggactgcgaa cacggactgg ctccaatatt gactgtgaga agctgcggag aaggttctct      180

agtctgcact ttatggtcga agtgaaaggg gatctgaccg ccaagaaaat ggtgctggcc      240

ctgctggagc tggctcagca ggaccatgga gctctggatt gctgcgtggt cgtgatcctg      300

tcccacgggt gccaggcttc tcatctgcag ttccccggag cagtgtacgg aacagacggc      360

tgtcctgtca gcgtggagaa gatcgtcaac atcttcaacg gcacttcttg ccctagtctg      420

gggggaaagc caaaactgtt ctttatccag gcctgtggcg gggaacagaa agatcacggc      480

ttcgaggtgg ccagcaccag ccctgaggac gaatcaccag ggagcaaccc tgaaccagat      540

gcaactccat tccaggaggg actgaggacc tttgaccagc tggatgctat ctcaagcctg      600

cccactccta gtgacatttt cgtgtcttac agtaccttcc caggctttgt ctcatggcgc      660

gatcccaagt cagggagctg gtacgtggag acactggacg acatctttga acagtgggcc      720

cattcagagg acctgcagag cctgctgctg cgagtggcaa acgctgtctc tgtgaagggc      780

atctacaaac agatgcccgg gtgcttcaat tttctgagaa agaaactgtt ctttaagact      840

tcc                                                                    843


<210>  115
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inducible proapoptotic polypeptide

<400>  115

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu Arg Gly Asn Ala Asp 
        115                 120                 125             


Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly His Cys Leu Ile Ile 
    130                 135                 140                 


Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu Arg Thr Arg Thr Gly 
145                 150                 155                 160 


Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg Phe Ser Ser Leu His 
                165                 170                 175     


Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala Lys Lys Met Val Leu 
            180                 185                 190         


Ala Leu Leu Glu Leu Ala Gln Gln Asp His Gly Ala Leu Asp Cys Cys 
        195                 200                 205             


Val Val Val Ile Leu Ser His Gly Cys Gln Ala Ser His Leu Gln Phe 
    210                 215                 220                 


Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro Val Ser Val Glu Lys 
225                 230                 235                 240 


Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro Ser Leu Gly Gly Lys 
                245                 250                 255     


Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly Glu Gln Lys Asp His 
            260                 265                 270         


Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp Glu Ser Pro Gly Ser 
        275                 280                 285             


Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu Gly Leu Arg Thr Phe 
    290                 295                 300                 


Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr Pro Ser Asp Ile Phe 
305                 310                 315                 320 


Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser Trp Arg Asp Pro Lys 
                325                 330                 335     


Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp Ile Phe Glu Gln Trp 
            340                 345                 350         


Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu Arg Val Ala Asn Ala 
        355                 360                 365             


Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro Gly Cys Phe Asn Phe 
    370                 375                 380                 


Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
385                 390                 


<210>  116
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  inducible proapoptotic polypeptide

<400>  116
ggggtccagg tcgagactat ttcaccaggg gatgggcgaa catttccaaa aaggggccag       60

acttgcgtcg tgcattacac cgggatgctg gaggacggga agaaagtgga cagctccagg      120

gatcgcaaca agcccttcaa gttcatgctg ggaaagcagg aagtgatccg aggatgggag      180

gaaggcgtgg cacagatgtc agtcggccag cgggccaaac tgaccattag ccctgactac      240

gcttatggag caacaggcca cccagggatc attccccctc atgccaccct ggtcttcgat      300

gtggaactgc tgaagctgga gggaggagga ggatccggat ttggggacgt gggggccctg      360

gagtctctgc gaggaaatgc cgatctggct tacatcctga gcatggaacc ctgcggccac      420

tgtctgatca ttaacaatgt gaacttctgc agagaaagcg gactgcgaac acggactggc      480

tccaatattg actgtgagaa gctgcggaga aggttctcta gtctgcactt tatggtcgaa      540

gtgaaagggg atctgaccgc caagaaaatg gtgctggccc tgctggagct ggctcagcag      600

gaccatggag ctctggattg ctgcgtggtc gtgatcctgt cccacgggtg ccaggcttct      660

catctgcagt tccccggagc agtgtacgga acagacggct gtcctgtcag cgtggagaag      720

atcgtcaaca tcttcaacgg cacttcttgc cctagtctgg ggggaaagcc aaaactgttc      780

tttatccagg cctgtggcgg ggaacagaaa gatcacggct tcgaggtggc cagcaccagc      840

cctgaggacg aatcaccagg gagcaaccct gaaccagatg caactccatt ccaggaggga      900

ctgaggacct ttgaccagct ggatgctatc tcaagcctgc ccactcctag tgacattttc      960

gtgtcttaca gtaccttccc aggctttgtc tcatggcgcg atcccaagtc agggagctgg     1020

tacgtggaga cactggacga catctttgaa cagtgggccc attcagagga cctgcagagc     1080

ctgctgctgc gagtggcaaa cgctgtctct gtgaagggca tctacaaaca gatgcccggg     1140

tgcttcaatt ttctgagaaa gaaactgttc tttaagactt cc                        1182


