                         SEQUENCE LISTING

<110>  Institut Gustave-Roussy
 
<120>  USE OF DUOX1 INHIBITORS FOR TREATING CANCER

<130>  B378536 D39876

<150>  EP19306093.6
<151>  2019-09-11

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  5675
<212>  DNA
<213>  homo sapiens

<400>  1
gcagagctgc agaggcaccg gacgagagag ggctccgcgg gcccagctgg cagccaggcc       60

ggagacaagt tgcagtcccg ggctctggtg acgccgtggc cgcagctgga agaggaaaac      120

aaggatcaga ttggagaagt gatttatcta agatcccaca gtggactggg agcagcactg      180

agacctcagc ctagtctcct gatccccaag cagggccctg cctaaggaac acactctgca      240

gagtgctggg ccaaagcagg gttttccaac taatcttaga aggtaaagtc catgaagggt      300

ctccattttg ggacattcta atccctgagc ccctattatt ttcatcatgg gcttctgcct      360

ggctctagca tggacacttc tggttggggc atggacccct ctgggagctc agaaccccat      420

ttcgtgggag gtgcagcgat ttgatgggtg gtacaacaac ctcatggagc acagatgggg      480

cagcaaaggc tcccggctgc agcgcctggt cccagccagc tatgcagatg gcgtgtacca      540

gcccttggga gaaccccacc tgcccaaccc ccgagacctt agcaacacca tctcaagggg      600

ccctgcaggg ctggcctccc tgagaaaccg cacagtgttg ggggtcttct ttggctatca      660

cgtgctttca gacctggtga gcgtggaaac tcccggctgc cccgccgagt tcctcaacat      720

tcgcatcccg cccggagacc ccatgttcga ccccgaccag cgcggggacg tggtgctgcc      780

cttccagaga agccgctggg accccgagac cggacggagt cccagcaatc cccgggaccc      840

ggccaaccag gtgacgggct ggctggacgg cagcgccatc tatggttcct cgcattcctg      900

gagcgacgcg ctgcggagct tctccagggg acagctggcg tcggggcccg accccgcttt      960

tccccgagac tcgcagaacc ccctgctcat gtgggcggcg cccgaccccg ccaccgggca     1020

gaacgggccc cgggggctgt acgccttcgg ggcagagaga gggaaccggg aacccttcct     1080

gcaggcgctg ggcctgctct ggttccgcta ccacaacctg tgggcgcaga ggctggcccg     1140

ccagcaccca gactgggagg acgaggagct gttccagcac gcacgcaaga gggtcatcgc     1200

cacctaccag aacatcgctg tgtatgagtg gctgcccagc ttcctgcaga aaacactccc     1260

ggagtataca ggataccggc catttctgga ccccagcatc tcctcagagt tcgtggcggc     1320

ctctgagcag ttcctgtcca ccatggtgcc ccctggcgtc tacatgagaa atgccagctg     1380

ccacttccag ggggtcatca atcggaactc aagtgtctcc agagctctcc gggtctgcaa     1440

cagctactgg agccgtgagc acccaagcct acaaagtgct gaagatgtgg atgcactgct     1500

gctgggcatg gcctcccaga tcgcagagcg agaggaccat gtgttggttg aagatgtgcg     1560

ggatttctgg cctgggccac tgaagttttc ccgcacagac cacctggcca gctgcctgca     1620

gcggggccgg gatctgggcc tgccctctta caccaaggcc agggcagcac tgggcttgtc     1680

tcccattacc cgctggcagg acatcaaccc tgcactctcc cggagcaatg acactgtact     1740

ggaggccaca gctgccctgt acaaccagga cttatcctgg ctagagctgc tccctggggg     1800

actcctggag agccaccggg accctggacc tctgttcagc accatcgtcc ttgaacaatt     1860

tgtgcggcta cgggatggtg accgctactg gtttgagaac accaggaatg ggctgttctc     1920

caagaaggag attgaagaaa tccgaaatac caccctgcag gacgtgctgg tcgctgttat     1980

caacattgac cccagtgctc tgcagcccaa tgtctttgtc tggcataaag gagacccctg     2040

tccgcagccg agacagctca gcactgaagg cctgccagcg tgtgctccct ctgttgttcg     2100

tgactatttt gagggcagtg gatttggctt cggggtcacc atcgggaccc tctgttgctt     2160

ccctttggtg agcctgctca gtgcctggat tgttgcccgg ctccggatga gaaatttcaa     2220

gaggctccag ggccaggacc gccagagcat cgtgtctgag aagctcgtgg gaggcatgga     2280

agctttggaa tggcaaggcc acaaggagcc ctgccggccc gtgcttgtgt acctgcagcc     2340

cgggcagatc cgtgtggtag atggcaggct caccgtgctc cgcaccatcc agctgcagcc     2400

tccacagaag gtcaacttcg tcctgtccag caaccgtgga cgccgcactc tgctgctcaa     2460

gatccccaag gagtatgacc tggtgctgct gtttaacttg gaggaagagc ggcaggcgct     2520

ggtggaaaat ctccggggag ctctgaagga gagcgggttg agcatccagg agtgggagct     2580

gcgggagcag gagctgatga gagcagctgt gacacgggag cagcggaggc acctcctgga     2640

gacctttttc aggcaccttt tctcccaggt gctggacatc aaccaggccg acgcagggac     2700

cctgcccctg gactcctccc agaaggtgcg ggaggccctg acctgtgagc tgagcagggc     2760

cgagtttgcc gagtccctgg gcctcaagcc ccaggacatg tttgtggagt ccatgttctc     2820

tctggctgac aaggatggca atggctacct gtccttccga gagttcctgg acatcctggt     2880

ggtcttcatg aaaggctctc ctgaggaaaa gtctcgcctt atgttccgca tgtacgactt     2940

tgatgggaat ggcctcattt ccaaggatga gttcatcagg atgctgagat ccttcatcga     3000

gatctccaac aactgcctgt ccaaggccca gctggctgag gtggtggagt ccatgttccg     3060

ggagtcggga ttccaggaca aggaggaact gacatgggaa gattttcact tcatgctgcg     3120

ggaccacaat agcgagctcc gcttcacgca gctctgtgtc aaaggggtgg aggtgcctga     3180

agtcatcaag gacctctgcc ggcgagcctc ctacatcagc caggatatga tctgtccctc     3240

tcccagagtg agtgcccgct gttcccgcag cgacattgag actgagttga cacctcagag     3300

actgcagtgc cccatggaca cagaccctcc ccaggagatt cggcggaggt ttggcaagaa     3360

ggtaacgtca ttccagccct tgctgttcac tgaggcgcac cgagagaagt tccaacgcag     3420

ctgtctccac cagacggtgc aacagttcaa gcgcttcatt gagaactacc ggcgccacat     3480

cggctgcgtg gccgtgttct acgccatcgc tggggggctt ttcctggaga gggcctacta     3540

ctacgccttt gccgcacatc acacgggcat cacagacacc acccgcgtgg gaatcatcct     3600

gtcgcggggc acagcagcca gcatctcttt catgttctcc tacatcttgc tcaccatgtg     3660

ccgcaacctc atcaccttcc tgcgagaaac cttcctcaac cgctacgtgc ccttcgacgc     3720

cgccgtggac ttccatcgcc tcattgcctc caccgccatc gtcctcacag tcttacacag     3780

tgtgggccat gtggtgaatg tgtacctgtt ctccatcagc cccctcagcg tcctctcttg     3840

cctctttcct ggcctcttcc atgatgatgg gtctgagctc ccccagaagt attactggtg     3900

gttcttccag accgtaccag gcctcacggg ggttgtgctg ctcctgatcc tggccatcat     3960

gtatgtcttt gcctcccacc acttccgccg ccgcagtttc cggggcttct ggctgaccca     4020

ccacctctac atcctgctct atgtcctgct catcatccat ggtagctttg ccctgatcca     4080

gctgccccgt ttccacatct tcttcctggt cccagcaatc atctatgggg gcgacaagct     4140

ggtgagcctg agccggaaga aggtggagat cagcgtggtg aaggcggagc tgctgccctc     4200

aggagtgacc cacctgcggt tccagcggcc ccagggcttt gagtacaagt cagggcagtg     4260

ggtgcggatc gcttgcctgg ctctggggac caccgagtac caccccttca cactgacctc     4320

tgcgccccat gaggacacgc ttagcctgca catccgggca gcagggccct ggaccactcg     4380

cctcagggag atctactcag ccccgacggg tgacagatgt gccagatacc caaagctgta     4440

ccttgatgga ccatttggag agggccacca ggagtggcat aagtttgagg tgtcagtgtt     4500

agtgggaggg ggcattgggg tcaccccttt tgcctccatc ctcaaagacc tggtcttcaa     4560

gtcatccgtc agctgccaag tgttctgtaa gaagatctac ttcatctggg tgacgcggac     4620

ccagcgtcag tttgagtggc tggctgacat catccgagag gtggaggaga atgaccacca     4680

ggacctggtg tctgtgcaca tctacatcac ccagctggct gagaagttcg acctcaggac     4740

cactatgctg tacatctgtg agcggcactt ccagaaggtt ctgaaccgga gtctattcac     4800

aggcctgcgc tccatcaccc actttggccg tccccccttt gagcccttct tcaactccct     4860

gcaggaggtc cacccccagg tccggaagat cggggtgttt agctgtggcc cccctggcat     4920

gaccaagaat gtggaaaagg cctgtcagct catcaacagg caggaccgga ctcacttctc     4980

ccaccattat gagaacttct aggcccctgc ccgggggttc tgcccactgc ccagttgagc     5040

agaggtttga gcccacacct cacctctgtt cttcctattt ctggctgcct cagccttctc     5100

tgatttccca cctcccaacc ttgttccagg tggccatagt cagtcaccat gtgtgggctc     5160

agggaccccc aggaccagga tgtgtctcag cctggagaaa tggtgggggg gcagtgtcta     5220

gggactagag tgagaagtag gggagctact gatttggggc aaagtgaaac ctctgcttcc     5280

agacttcaga aacaaatctc agaagacaag ctgacctgac aagtactatg tgtgtgcatg     5340

tctgtatgtg tgttggggcg gtgagtgtaa ggatgcagtg ggagcatgga tgctggcatc     5400

ttagaaccct ccctactccc atacctcctc ctcttctggg ctccccactg tcagacgggc     5460

tggcaaatgc cttgcaggag gtagaggctg gacccatggc aagccattta cagaaaccca     5520

ctcggcaccc cagtctaaca ccacaactaa tttcacccaa ggttttaagc acgttctttc     5580

atcagaccct ggcccaatac ctatgtatgc aatgctcctc agccctcttc tccctgctcc     5640

agtagtctcc cttccaaata aatcactttt ctgcc                                5675


<210>  2
<211>  5483
<212>  DNA
<213>  homo sapiens

<400>  2
gcagagctgc agaggcaccg gacgagagag ggctccgcgg gcccagctgg cagccaggcc       60

ggagacaagt tgcagtcccg ggctctggtg acgccgtggc cgcagggtct ccattttggg      120

acattctaat ccctgagccc ctattatttt catcatgggc ttctgcctgg ctctagcatg      180

gacacttctg gttggggcat ggacccctct gggagctcag aaccccattt cgtgggaggt      240

gcagcgattt gatgggtggt acaacaacct catggagcac agatggggca gcaaaggctc      300

ccggctgcag cgcctggtcc cagccagcta tgcagatggc gtgtaccagc ccttgggaga      360

accccacctg cccaaccccc gagaccttag caacaccatc tcaaggggcc ctgcagggct      420

ggcctccctg agaaaccgca cagtgttggg ggtcttcttt ggctatcacg tgctttcaga      480

cctggtgagc gtggaaactc ccggctgccc cgccgagttc ctcaacattc gcatcccgcc      540

cggagacccc atgttcgacc ccgaccagcg cggggacgtg gtgctgccct tccagagaag      600

ccgctgggac cccgagaccg gacggagtcc cagcaatccc cgggacccgg ccaaccaggt      660

gacgggctgg ctggacggca gcgccatcta tggttcctcg cattcctgga gcgacgcgct      720

gcggagcttc tccaggggac agctggcgtc ggggcccgac cccgcttttc cccgagactc      780

gcagaacccc ctgctcatgt gggcggcgcc cgaccccgcc accgggcaga acgggccccg      840

ggggctgtac gccttcgggg cagagagagg gaaccgggaa cccttcctgc aggcgctggg      900

cctgctctgg ttccgctacc acaacctgtg ggcgcagagg ctggcccgcc agcacccaga      960

ctgggaggac gaggagctgt tccagcacgc acgcaagagg gtcatcgcca cctaccagaa     1020

catcgctgtg tatgagtggc tgcccagctt cctgcagaaa acactcccgg agtatacagg     1080

ataccggcca tttctggacc ccagcatctc ctcagagttc gtggcggcct ctgagcagtt     1140

cctgtccacc atggtgcccc ctggcgtcta catgagaaat gccagctgcc acttccaggg     1200

ggtcatcaat cggaactcaa gtgtctccag agctctccgg gtctgcaaca gctactggag     1260

ccgtgagcac ccaagcctac aaagtgctga agatgtggat gcactgctgc tgggcatggc     1320

ctcccagatc gcagagcgag aggaccatgt gttggttgaa gatgtgcggg atttctggcc     1380

tgggccactg aagttttccc gcacagacca cctggccagc tgcctgcagc ggggccggga     1440

tctgggcctg ccctcttaca ccaaggccag ggcagcactg ggcttgtctc ccattacccg     1500

ctggcaggac atcaaccctg cactctcccg gagcaatgac actgtactgg aggccacagc     1560

tgccctgtac aaccaggact tatcctggct agagctgctc cctgggggac tcctggagag     1620

ccaccgggac cctggacctc tgttcagcac catcgtcctt gaacaatttg tgcggctacg     1680

ggatggtgac cgctactggt ttgagaacac caggaatggg ctgttctcca agaaggagat     1740

tgaagaaatc cgaaatacca ccctgcagga cgtgctggtc gctgttatca acattgaccc     1800

cagtgctctg cagcccaatg tctttgtctg gcataaagga gacccctgtc cgcagccgag     1860

acagctcagc actgaaggcc tgccagcgtg tgctccctct gttgttcgtg actattttga     1920

gggcagtgga tttggcttcg gggtcaccat cgggaccctc tgttgcttcc ctttggtgag     1980

cctgctcagt gcctggattg ttgcccggct ccggatgaga aatttcaaga ggctccaggg     2040

ccaggaccgc cagagcatcg tgtctgagaa gctcgtggga ggcatggaag ctttggaatg     2100

gcaaggccac aaggagccct gccggcccgt gcttgtgtac ctgcagcccg ggcagatccg     2160

tgtggtagat ggcaggctca ccgtgctccg caccatccag ctgcagcctc cacagaaggt     2220

caacttcgtc ctgtccagca accgtggacg ccgcactctg ctgctcaaga tccccaagga     2280

gtatgacctg gtgctgctgt ttaacttgga ggaagagcgg caggcgctgg tggaaaatct     2340

ccggggagct ctgaaggaga gcgggttgag catccaggag tgggagctgc gggagcagga     2400

gctgatgaga gcagctgtga cacgggagca gcggaggcac ctcctggaga cctttttcag     2460

gcaccttttc tcccaggtgc tggacatcaa ccaggccgac gcagggaccc tgcccctgga     2520

ctcctcccag aaggtgcggg aggccctgac ctgtgagctg agcagggccg agtttgccga     2580

gtccctgggc ctcaagcccc aggacatgtt tgtggagtcc atgttctctc tggctgacaa     2640

ggatggcaat ggctacctgt ccttccgaga gttcctggac atcctggtgg tcttcatgaa     2700

aggctctcct gaggaaaagt ctcgccttat gttccgcatg tacgactttg atgggaatgg     2760

cctcatttcc aaggatgagt tcatcaggat gctgagatcc ttcatcgaga tctccaacaa     2820

ctgcctgtcc aaggcccagc tggctgaggt ggtggagtcc atgttccggg agtcgggatt     2880

ccaggacaag gaggaactga catgggaaga ttttcacttc atgctgcggg accacaatag     2940

cgagctccgc ttcacgcagc tctgtgtcaa aggggtggag gtgcctgaag tcatcaagga     3000

cctctgccgg cgagcctcct acatcagcca ggatatgatc tgtccctctc ccagagtgag     3060

tgcccgctgt tcccgcagcg acattgagac tgagttgaca cctcagagac tgcagtgccc     3120

catggacaca gaccctcccc aggagattcg gcggaggttt ggcaagaagg taacgtcatt     3180

ccagcccttg ctgttcactg aggcgcaccg agagaagttc caacgcagct gtctccacca     3240

gacggtgcaa cagttcaagc gcttcattga gaactaccgg cgccacatcg gctgcgtggc     3300

cgtgttctac gccatcgctg gggggctttt cctggagagg gcctactact acgcctttgc     3360

cgcacatcac acgggcatca cagacaccac ccgcgtggga atcatcctgt cgcggggcac     3420

agcagccagc atctctttca tgttctccta catcttgctc accatgtgcc gcaacctcat     3480

caccttcctg cgagaaacct tcctcaaccg ctacgtgccc ttcgacgccg ccgtggactt     3540

ccatcgcctc attgcctcca ccgccatcgt cctcacagtc ttacacagtg tgggccatgt     3600

ggtgaatgtg tacctgttct ccatcagccc cctcagcgtc ctctcttgcc tctttcctgg     3660

cctcttccat gatgatgggt ctgagctccc ccagaagtat tactggtggt tcttccagac     3720

cgtaccaggc ctcacggggg ttgtgctgct cctgatcctg gccatcatgt atgtctttgc     3780

ctcccaccac ttccgccgcc gcagtttccg gggcttctgg ctgacccacc acctctacat     3840

cctgctctat gtcctgctca tcatccatgg tagctttgcc ctgatccagc tgccccgttt     3900

ccacatcttc ttcctggtcc cagcaatcat ctatgggggc gacaagctgg tgagcctgag     3960

ccggaagaag gtggagatca gcgtggtgaa ggcggagctg ctgccctcag gagtgaccca     4020

cctgcggttc cagcggcccc agggctttga gtacaagtca gggcagtggg tgcggatcgc     4080

ttgcctggct ctggggacca ccgagtacca ccccttcaca ctgacctctg cgccccatga     4140

ggacacgctt agcctgcaca tccgggcagc agggccctgg accactcgcc tcagggagat     4200

ctactcagcc ccgacgggtg acagatgtgc cagataccca aagctgtacc ttgatggacc     4260

atttggagag ggccaccagg agtggcataa gtttgaggtg tcagtgttag tgggaggggg     4320

cattggggtc accccttttg cctccatcct caaagacctg gtcttcaagt catccgtcag     4380

ctgccaagtg ttctgtaaga agatctactt catctgggtg acgcggaccc agcgtcagtt     4440

tgagtggctg gctgacatca tccgagaggt ggaggagaat gaccaccagg acctggtgtc     4500

tgtgcacatc tacatcaccc agctggctga gaagttcgac ctcaggacca ctatgctgta     4560

catctgtgag cggcacttcc agaaggttct gaaccggagt ctattcacag gcctgcgctc     4620

catcacccac tttggccgtc ccccctttga gcccttcttc aactccctgc aggaggtcca     4680

cccccaggtc cggaagatcg gggtgtttag ctgtggcccc cctggcatga ccaagaatgt     4740

ggaaaaggcc tgtcagctca tcaacaggca ggaccggact cacttctccc accattatga     4800

gaacttctag gcccctgccc gggggttctg cccactgccc agttgagcag aggtttgagc     4860

ccacacctca cctctgttct tcctatttct ggctgcctca gccttctctg atttcccacc     4920

tcccaacctt gttccaggtg gccatagtca gtcaccatgt gtgggctcag ggacccccag     4980

gaccaggatg tgtctcagcc tggagaaatg gtgggggggc agtgtctagg gactagagtg     5040

agaagtaggg gagctactga tttggggcaa agtgaaacct ctgcttccag acttcagaaa     5100

caaatctcag aagacaagct gacctgacaa gtactatgtg tgtgcatgtc tgtatgtgtg     5160

ttggggcggt gagtgtaagg atgcagtggg agcatggatg ctggcatctt agaaccctcc     5220

ctactcccat acctcctcct cttctgggct ccccactgtc agacgggctg gcaaatgcct     5280

tgcaggaggt agaggctgga cccatggcaa gccatttaca gaaacccact cggcacccca     5340

gtctaacacc acaactaatt tcacccaagg ttttaagcac gttctttcat cagaccctgg     5400

cccaatacct atgtatgcaa tgctcctcag ccctcttctc cctgctccag tagtctccct     5460

tccaaataaa tcacttttct gcc                                             5483


<210>  3
<211>  1551
<212>  PRT
<213>  homo sapiens

<400>  3

Met Gly Phe Cys Leu Ala Leu Ala Trp Thr Leu Leu Val Gly Ala Trp 
1               5                   10                  15      


Thr Pro Leu Gly Ala Gln Asn Pro Ile Ser Trp Glu Val Gln Arg Phe 
            20                  25                  30          


Asp Gly Trp Tyr Asn Asn Leu Met Glu His Arg Trp Gly Ser Lys Gly 
        35                  40                  45              


Ser Arg Leu Gln Arg Leu Val Pro Ala Ser Tyr Ala Asp Gly Val Tyr 
    50                  55                  60                  


Gln Pro Leu Gly Glu Pro His Leu Pro Asn Pro Arg Asp Leu Ser Asn 
65                  70                  75                  80  


Thr Ile Ser Arg Gly Pro Ala Gly Leu Ala Ser Leu Arg Asn Arg Thr 
                85                  90                  95      


Val Leu Gly Val Phe Phe Gly Tyr His Val Leu Ser Asp Leu Val Ser 
            100                 105                 110         


Val Glu Thr Pro Gly Cys Pro Ala Glu Phe Leu Asn Ile Arg Ile Pro 
        115                 120                 125             


Pro Gly Asp Pro Met Phe Asp Pro Asp Gln Arg Gly Asp Val Val Leu 
    130                 135                 140                 


Pro Phe Gln Arg Ser Arg Trp Asp Pro Glu Thr Gly Arg Ser Pro Ser 
145                 150                 155                 160 


Asn Pro Arg Asp Pro Ala Asn Gln Val Thr Gly Trp Leu Asp Gly Ser 
                165                 170                 175     


Ala Ile Tyr Gly Ser Ser His Ser Trp Ser Asp Ala Leu Arg Ser Phe 
            180                 185                 190         


Ser Arg Gly Gln Leu Ala Ser Gly Pro Asp Pro Ala Phe Pro Arg Asp 
        195                 200                 205             


Ser Gln Asn Pro Leu Leu Met Trp Ala Ala Pro Asp Pro Ala Thr Gly 
    210                 215                 220                 


Gln Asn Gly Pro Arg Gly Leu Tyr Ala Phe Gly Ala Glu Arg Gly Asn 
225                 230                 235                 240 


Arg Glu Pro Phe Leu Gln Ala Leu Gly Leu Leu Trp Phe Arg Tyr His 
                245                 250                 255     


Asn Leu Trp Ala Gln Arg Leu Ala Arg Gln His Pro Asp Trp Glu Asp 
            260                 265                 270         


Glu Glu Leu Phe Gln His Ala Arg Lys Arg Val Ile Ala Thr Tyr Gln 
        275                 280                 285             


Asn Ile Ala Val Tyr Glu Trp Leu Pro Ser Phe Leu Gln Lys Thr Leu 
    290                 295                 300                 


Pro Glu Tyr Thr Gly Tyr Arg Pro Phe Leu Asp Pro Ser Ile Ser Ser 
305                 310                 315                 320 


Glu Phe Val Ala Ala Ser Glu Gln Phe Leu Ser Thr Met Val Pro Pro 
                325                 330                 335     


Gly Val Tyr Met Arg Asn Ala Ser Cys His Phe Gln Gly Val Ile Asn 
            340                 345                 350         


Arg Asn Ser Ser Val Ser Arg Ala Leu Arg Val Cys Asn Ser Tyr Trp 
        355                 360                 365             


Ser Arg Glu His Pro Ser Leu Gln Ser Ala Glu Asp Val Asp Ala Leu 
    370                 375                 380                 


Leu Leu Gly Met Ala Ser Gln Ile Ala Glu Arg Glu Asp His Val Leu 
385                 390                 395                 400 


Val Glu Asp Val Arg Asp Phe Trp Pro Gly Pro Leu Lys Phe Ser Arg 
                405                 410                 415     


Thr Asp His Leu Ala Ser Cys Leu Gln Arg Gly Arg Asp Leu Gly Leu 
            420                 425                 430         


Pro Ser Tyr Thr Lys Ala Arg Ala Ala Leu Gly Leu Ser Pro Ile Thr 
        435                 440                 445             


Arg Trp Gln Asp Ile Asn Pro Ala Leu Ser Arg Ser Asn Asp Thr Val 
    450                 455                 460                 


Leu Glu Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser Trp Leu Glu 
465                 470                 475                 480 


Leu Leu Pro Gly Gly Leu Leu Glu Ser His Arg Asp Pro Gly Pro Leu 
                485                 490                 495     


Phe Ser Thr Ile Val Leu Glu Gln Phe Val Arg Leu Arg Asp Gly Asp 
            500                 505                 510         


Arg Tyr Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser Lys Lys Glu 
        515                 520                 525             


Ile Glu Glu Ile Arg Asn Thr Thr Leu Gln Asp Val Leu Val Ala Val 
    530                 535                 540                 


Ile Asn Ile Asp Pro Ser Ala Leu Gln Pro Asn Val Phe Val Trp His 
545                 550                 555                 560 


Lys Gly Asp Pro Cys Pro Gln Pro Arg Gln Leu Ser Thr Glu Gly Leu 
                565                 570                 575     


Pro Ala Cys Ala Pro Ser Val Val Arg Asp Tyr Phe Glu Gly Ser Gly 
            580                 585                 590         


Phe Gly Phe Gly Val Thr Ile Gly Thr Leu Cys Cys Phe Pro Leu Val 
        595                 600                 605             


Ser Leu Leu Ser Ala Trp Ile Val Ala Arg Leu Arg Met Arg Asn Phe 
    610                 615                 620                 


Lys Arg Leu Gln Gly Gln Asp Arg Gln Ser Ile Val Ser Glu Lys Leu 
625                 630                 635                 640 


Val Gly Gly Met Glu Ala Leu Glu Trp Gln Gly His Lys Glu Pro Cys 
                645                 650                 655     


Arg Pro Val Leu Val Tyr Leu Gln Pro Gly Gln Ile Arg Val Val Asp 
            660                 665                 670         


Gly Arg Leu Thr Val Leu Arg Thr Ile Gln Leu Gln Pro Pro Gln Lys 
        675                 680                 685             


Val Asn Phe Val Leu Ser Ser Asn Arg Gly Arg Arg Thr Leu Leu Leu 
    690                 695                 700                 


Lys Ile Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe Asn Leu Glu Glu 
705                 710                 715                 720 


Glu Arg Gln Ala Leu Val Glu Asn Leu Arg Gly Ala Leu Lys Glu Ser 
                725                 730                 735     


Gly Leu Ser Ile Gln Glu Trp Glu Leu Arg Glu Gln Glu Leu Met Arg 
            740                 745                 750         


Ala Ala Val Thr Arg Glu Gln Arg Arg His Leu Leu Glu Thr Phe Phe 
        755                 760                 765             


Arg His Leu Phe Ser Gln Val Leu Asp Ile Asn Gln Ala Asp Ala Gly 
    770                 775                 780                 


Thr Leu Pro Leu Asp Ser Ser Gln Lys Val Arg Glu Ala Leu Thr Cys 
785                 790                 795                 800 


Glu Leu Ser Arg Ala Glu Phe Ala Glu Ser Leu Gly Leu Lys Pro Gln 
                805                 810                 815     


Asp Met Phe Val Glu Ser Met Phe Ser Leu Ala Asp Lys Asp Gly Asn 
            820                 825                 830         


Gly Tyr Leu Ser Phe Arg Glu Phe Leu Asp Ile Leu Val Val Phe Met 
        835                 840                 845             


Lys Gly Ser Pro Glu Glu Lys Ser Arg Leu Met Phe Arg Met Tyr Asp 
    850                 855                 860                 


Phe Asp Gly Asn Gly Leu Ile Ser Lys Asp Glu Phe Ile Arg Met Leu 
865                 870                 875                 880 


Arg Ser Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser Lys Ala Gln Leu 
                885                 890                 895     


Ala Glu Val Val Glu Ser Met Phe Arg Glu Ser Gly Phe Gln Asp Lys 
            900                 905                 910         


Glu Glu Leu Thr Trp Glu Asp Phe His Phe Met Leu Arg Asp His Asn 
        915                 920                 925             


Ser Glu Leu Arg Phe Thr Gln Leu Cys Val Lys Gly Val Glu Val Pro 
    930                 935                 940                 


Glu Val Ile Lys Asp Leu Cys Arg Arg Ala Ser Tyr Ile Ser Gln Asp 
945                 950                 955                 960 


Met Ile Cys Pro Ser Pro Arg Val Ser Ala Arg Cys Ser Arg Ser Asp 
                965                 970                 975     


Ile Glu Thr Glu Leu Thr Pro Gln Arg Leu Gln Cys Pro Met Asp Thr 
            980                 985                 990         


Asp Pro Pro Gln Glu Ile Arg Arg  Arg Phe Gly Lys Lys  Val Thr Ser 
        995                 1000                 1005             


Phe Gln  Pro Leu Leu Phe Thr  Glu Ala His Arg Glu  Lys Phe Gln 
    1010                 1015                 1020             


Arg Ser  Cys Leu His Gln Thr  Val Gln Gln Phe Lys  Arg Phe Ile 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Arg His Ile  Gly Cys Val Ala Val  Phe Tyr Ala 
    1040                 1045                 1050             


Ile Ala  Gly Gly Leu Phe Leu  Glu Arg Ala Tyr Tyr  Tyr Ala Phe 
    1055                 1060                 1065             


Ala Ala  His His Thr Gly Ile  Thr Asp Thr Thr Arg  Val Gly Ile 
    1070                 1075                 1080             


Ile Leu  Ser Arg Gly Thr Ala  Ala Ser Ile Ser Phe  Met Phe Ser 
    1085                 1090                 1095             


Tyr Ile  Leu Leu Thr Met Cys  Arg Asn Leu Ile Thr  Phe Leu Arg 
    1100                 1105                 1110             


Glu Thr  Phe Leu Asn Arg Tyr  Val Pro Phe Asp Ala  Ala Val Asp 
    1115                 1120                 1125             


Phe His  Arg Leu Ile Ala Ser  Thr Ala Ile Val Leu  Thr Val Leu 
    1130                 1135                 1140             


His Ser  Val Gly His Val Val  Asn Val Tyr Leu Phe  Ser Ile Ser 
    1145                 1150                 1155             


Pro Leu  Ser Val Leu Ser Cys  Leu Phe Pro Gly Leu  Phe His Asp 
    1160                 1165                 1170             


Asp Gly  Ser Glu Leu Pro Gln  Lys Tyr Tyr Trp Trp  Phe Phe Gln 
    1175                 1180                 1185             


Thr Val  Pro Gly Leu Thr Gly  Val Val Leu Leu Leu  Ile Leu Ala 
    1190                 1195                 1200             


Ile Met  Tyr Val Phe Ala Ser  His His Phe Arg Arg  Arg Ser Phe 
    1205                 1210                 1215             


Arg Gly  Phe Trp Leu Thr His  His Leu Tyr Ile Leu  Leu Tyr Val 
    1220                 1225                 1230             


Leu Leu  Ile Ile His Gly Ser  Phe Ala Leu Ile Gln  Leu Pro Arg 
    1235                 1240                 1245             


Phe His  Ile Phe Phe Leu Val  Pro Ala Ile Ile Tyr  Gly Gly Asp 
    1250                 1255                 1260             


Lys Leu  Val Ser Leu Ser Arg  Lys Lys Val Glu Ile  Ser Val Val 
    1265                 1270                 1275             


Lys Ala  Glu Leu Leu Pro Ser  Gly Val Thr His Leu  Arg Phe Gln 
    1280                 1285                 1290             


Arg Pro  Gln Gly Phe Glu Tyr  Lys Ser Gly Gln Trp  Val Arg Ile 
    1295                 1300                 1305             


Ala Cys  Leu Ala Leu Gly Thr  Thr Glu Tyr His Pro  Phe Thr Leu 
    1310                 1315                 1320             


Thr Ser  Ala Pro His Glu Asp  Thr Leu Ser Leu His  Ile Arg Ala 
    1325                 1330                 1335             


Ala Gly  Pro Trp Thr Thr Arg  Leu Arg Glu Ile Tyr  Ser Ala Pro 
    1340                 1345                 1350             


Thr Gly  Asp Arg Cys Ala Arg  Tyr Pro Lys Leu Tyr  Leu Asp Gly 
    1355                 1360                 1365             


Pro Phe  Gly Glu Gly His Gln  Glu Trp His Lys Phe  Glu Val Ser 
    1370                 1375                 1380             


Val Leu  Val Gly Gly Gly Ile  Gly Val Thr Pro Phe  Ala Ser Ile 
    1385                 1390                 1395             


Leu Lys  Asp Leu Val Phe Lys  Ser Ser Val Ser Cys  Gln Val Phe 
    1400                 1405                 1410             


Cys Lys  Lys Ile Tyr Phe Ile  Trp Val Thr Arg Thr  Gln Arg Gln 
    1415                 1420                 1425             


Phe Glu  Trp Leu Ala Asp Ile  Ile Arg Glu Val Glu  Glu Asn Asp 
    1430                 1435                 1440             


His Gln  Asp Leu Val Ser Val  His Ile Tyr Ile Thr  Gln Leu Ala 
    1445                 1450                 1455             


Glu Lys  Phe Asp Leu Arg Thr  Thr Met Leu Tyr Ile  Cys Glu Arg 
    1460                 1465                 1470             


His Phe  Gln Lys Val Leu Asn  Arg Ser Leu Phe Thr  Gly Leu Arg 
    1475                 1480                 1485             


Ser Ile  Thr His Phe Gly Arg  Pro Pro Phe Glu Pro  Phe Phe Asn 
    1490                 1495                 1500             


Ser Leu  Gln Glu Val His Pro  Gln Val Arg Lys Ile  Gly Val Phe 
    1505                 1510                 1515             


Ser Cys  Gly Pro Pro Gly Met  Thr Lys Asn Val Glu  Lys Ala Cys 
    1520                 1525                 1530             


Gln Leu  Ile Asn Arg Gln Asp  Arg Thr His Phe Ser  His His Tyr 
    1535                 1540                 1545             


Glu Asn  Phe 
    1550     


<210>  4
<211>  5267
<212>  DNA
<213>  mus musculus

<400>  4
caatatttaa tcccacgtta ccatttccat catggggttc cacttagctc tggcctggat       60

tctcctggtt gggacactgg cttctttggg agctcagaac tccatttctt gggaggtaca      120

gcgatttgat ggatggtata acaacctcat ggagcacaga tggggcagca aaggctctcg      180

gctgcagcgc cttgttccag ccagctatgc agatggtgtc taccagcccc tgaaagaacc      240

ctacctgcct aacccccgac accttagtaa cagggtcatg agaggttctg cagggcagcc      300

atctcttcgg aaccgtacag tcctgggtgt cttctttggc taccacgtgc tctcagacct      360

ggtgagtgtg gaaacaccag gctgccccgc agagttcctc aacatttaca tcccgcatgg      420

ggacccggtg ttcgaccctg acaagcgcgg gaacgtggtg ctgccctttc aaaggagccg      480

ctgggaccgc aacactggac agagccccag caacccccgg gaccagagca accaggtgac      540

cggctggcta gatggcagcg ccatctatgg ctcctctcat tcctggagtg acactctgag      600

gagcttctct ggaggacagc tggcttctgg gcctgaccct gctttcccat cggactccca      660

gagctctctg ctcatgtgga tggcgccgga cccctccaca gggcagggag ggccacgggg      720

ggtgtatgcc ttcggggccc agcgcgggaa cagggagccc tttctgcagg ctctgggctt      780

gttgtggttt cgctaccaca acctgtgtgc caggaagctg gcgcaggagc acccgcactg      840

gggggatgag gaactgttcc agcatgctcg caagagggtc attgccacct accagaacat      900

tgcgatgtat gagtggctgc ccagcttcct gaagcaaact cctccggagt atccaggata      960

ccgtccattt ctggacccca gtatctcccc agagttcgtt gtggcctctg agcagttcct     1020

ctctaccatg gtgccctctg gggtctacat gaggaatgcc agttgtcatt tccaggggat     1080

tcccagtcat aactcaagtg tctctggagc tctccgggtc tgcaacagct actggagtcg     1140

agagcacccc aagctacaaa gggctgaaga tgtggatgca ctgctgctgg gcatggcctc     1200

ccagattgct gagagagagg accacgtggt ggttgaggac atgcaagatt tctggcctgg     1260

gccactgaag ttttcccgta cagactacct ggccagctgc ctgcagaggg gccgggatct     1320

aggcctgcct tcttacacca aagccaggga ggcactgggc ctgtctccca tttcccactg     1380

gcaggacatc aaccctgcac tctccaggag caatggcact gtgctggagg ccacagctgc     1440

cctgtacaat caggacctgt ctcggctgga gctactccca ggggggcttc tggagagcca     1500

tggagaccct ggaccccttt tcagcactat tgtccttgac cagtttgtca ggctacgaga     1560

tggtgaccgt tactggtttg aaaacaccag gaacggattg ttctctaagg aagagatcgc     1620

agagatccga aacacttccc tacgggacat tctagtggct gtcaccaatg tggaccccag     1680

tgccctacag cccaatgtct tcttttggct tgcaggagac ccctgtccac agccaagtca     1740

gctcagcgcc aagggcctgc cagcctgtgc ccccctcttc attcgggact atttcgaggg     1800

gagtggattt ggcttcggac tcaccattgg gaccctttgc tgtttcccct tagtcagcct     1860

ccttagtgcc tggattgttg cccggcttcg aaagaggaat ttcaagaggc tccagagaca     1920

agaccgccag agcatcatgt cggagaagct tgtaggggga gtggaagctt tggagtggca     1980

gggccgcaat gaaccctgca ggccagtgct tgtgcactta cagccgggac agattcgagt     2040

agtggatggc aggctcaccg tgctccggac catccagctg cgacccccac agcaggtcaa     2100

cctcatcctg tccagcaacc gtggacgccg caccctgctg ctcaagatcc ccaaggagta     2160

tgacctggtt ctgttgttta acatggagga ggaacggcag gcactggtgg aaaacgtcag     2220

gggagctctg aaggaaaatg ggctgagctt ccaggagtgg gaactgaggg agcaggagct     2280

gatgagggca gcagtgacca ggcaacaacg gggccacctc ctggagacct tcttcaggca     2340

ccttttctcc caggtgttag acatcaatca ggctgatgca gggactctgc ctctggattc     2400

ctcgaccaaa gtgcgtgagg ccctgacctg tgagctgagc agagctgagt ttgcagactc     2460

cctaggcctc aagccccagg acatgtttgt ggagtccatg ttttctctag ccgacaagga     2520

tggcaatggc tacctgtcct tccgggagtt cctggacatc ctggtggtct tcatgaaagg     2580

ctccccagag gagaagtctc gtcttatgtt ccgaatgtat gactttgatg ggaacggtct     2640

catttccaag gatgagttca ttaggatgct aaggtccttc atcgagatct ccaacaactg     2700

cctgtccaag gcccagctgg ctgaggtggt tgagtctatg ttccgggagt ctggcttcca     2760

ggacaaggag gagctgacct gggaggactt ccacttcatg ctgcgggacc acgacagtga     2820

tctccgattc acacagctct gtgtcaaagg tgtggaagtg ccggaagtga tcaagaacct     2880

ctgccggcga gcctcctaca tcagccagga gaagatctgc ccttcgccca gaatgagcgc     2940

ccactgtgcc cgaaacaaca tgaagactgc gtcatcacca cagagactgc agtgccccat     3000

ggacacagac cctcctcaag agattcgacg gaggtttggc aaaaaggtaa cttcattcca     3060

gcccttactg ttcactgagg cacaccgaga gaagtttcaa cgcagccgcc gccaccaaac     3120

ggtgcagcag ttcaagcgct ttattgagaa ttacaggcgc cacattggct gtgtggcggt     3180

gttttacacc atcactgggg cgctcttcct ggagagagcc tactactatg catttgcagc     3240

acaccacagc ggcatcaccg ataccacccg tgtaggcatc atcctgtccc ggggcacggc     3300

ggccagcatc tcctttatgt tttcctacat cctgctcacc atgtgtcgca acctcatcac     3360

cttcttgcgg gagaccttcc tcaaccgcta cattcccttc gatgctgccg tggacttcca     3420

tcgcctcatc gcctccacgg ccatcatcct cacagtctta cacagtgctg gccacgtagt     3480

gaatgtgtac ctgttctcca tcagtccact cagtgtcctc tcttgcctct tccctggcct     3540

cttccacgat gatgggtcgg agttccctca gaagtattac tggtggttct tccagactgt     3600

gccaggtctc actggggtcc tcctgctcct ggccctggcc atcatgtacg tcttcgcctc     3660

ccaccacttc cgccgccgca gtttccgggg cttctggctg acccatcacc tctacatttt     3720

tctctacatt ctgctcatca tacatggcag ctttgctctg atccagatgc cccggttcca     3780

catcttcttc ctggtccctg caattattta tgtgggggac aagctggtga gcctgagccg     3840

gaagaaggtg gagatcagcg tggtgaaggc tgagctgctg ccatcaggag tgacccacct     3900

gcggttccag aggcctcagg gctttgagta taagtcaggg cagtgggttc ggattgcgtg     3960

cctggctctg ggaaccaccg agtatcaccc tttcacactg acttctgcac cccacgagga     4020

cacactcagc ctgcacatcc gggcggctgg accctggacc actcgcctca gggaaatcta     4080

ctcaccccca acgggtgaca cctgtgccag atacccaaag ctgtacctcg atggaccgtt     4140

tggagagggc caccaggagt ggcacaagtt tgaggtgtca gtgctggtag gagggggcat     4200

tggagtcact ccctttgcct ccatcctcaa agacctggtt ttcaagtcat cagtcagctg     4260

ccaagtgttc tgtaagaaga tctacttcat ctgggtgaca aggactcaga ggcagtttga     4320

gtggctggct gacatcatcc gggaggtgga ggagaatgac cgccaggacc tggtgtctgt     4380

gcacatctat attactcagc tggctgagaa gttcgacctc aggaccacca tgctgtacat     4440

ctgtgagcgg cacttccaga aggtgctgaa caggagtctg ttcacgggcc tgcgctccat     4500

cacccacttt ggtcgccctc cctttgagcc ctttttcaac tctctgcagg aagtccaccc     4560

ccaagtccga aagattggag tatttagctg tggtccccct ggcatgacca agaatgtgga     4620

gaaggcttgt cagctcatca acaggcagga caggactcat ttttctcacc attatgagaa     4680

cttctaggcc tcctgcccag caactatgcc cactactgcc ctgctgggac agcaggggct     4740

ttggcctgtg ccttaaccca gtactcattt ctggccacct cagccttggc ccttcccacc     4800

tgccaacttg gttggtccaa gtagcctcgc tcaggcatca tgtgtaggct cagagatctc     4860

tagggccaga atgtgtcttg agtttgtcga aggagcactg tttaagaact ataggttcag     4920

aagtagggga gcttttgggt tgagacaaag tgagaattaa gcaaaaactt gacagtagac     4980

aacctgtcaa gtttttgaaa gtgagtctga gtgatagtat ggatgctggc gtcttcaagt     5040

cctcttcact gtgttcttcc tctcttcaaa atggttggga gatgtcttag agtagccagg     5100

ggcaacttac agaaaccctc aggaccagcc taactgaaca actgatctct caaaatgtaa     5160

aatgtagtca gacctttctg tgcccactaa ccgcctggag cagtgcccct cagccccatc     5220

tccctcttct agtggtctgt tttgcaaata aacggtgttt ccccctt                   5267


<210>  5
<211>  1551
<212>  PRT
<213>  mus musculus

<400>  5

Met Gly Phe His Leu Ala Leu Ala Trp Ile Leu Leu Val Gly Thr Leu 
1               5                   10                  15      


Ala Ser Leu Gly Ala Gln Asn Ser Ile Ser Trp Glu Val Gln Arg Phe 
            20                  25                  30          


Asp Gly Trp Tyr Asn Asn Leu Met Glu His Arg Trp Gly Ser Lys Gly 
        35                  40                  45              


Ser Arg Leu Gln Arg Leu Val Pro Ala Ser Tyr Ala Asp Gly Val Tyr 
    50                  55                  60                  


Gln Pro Leu Lys Glu Pro Tyr Leu Pro Asn Pro Arg His Leu Ser Asn 
65                  70                  75                  80  


Arg Val Met Arg Gly Ser Ala Gly Gln Pro Ser Leu Arg Asn Arg Thr 
                85                  90                  95      


Val Leu Gly Val Phe Phe Gly Tyr His Val Leu Ser Asp Leu Val Ser 
            100                 105                 110         


Val Glu Thr Pro Gly Cys Pro Ala Glu Phe Leu Asn Ile Tyr Ile Pro 
        115                 120                 125             


His Gly Asp Pro Val Phe Asp Pro Asp Lys Arg Gly Asn Val Val Leu 
    130                 135                 140                 


Pro Phe Gln Arg Ser Arg Trp Asp Arg Asn Thr Gly Gln Ser Pro Ser 
145                 150                 155                 160 


Asn Pro Arg Asp Gln Ser Asn Gln Val Thr Gly Trp Leu Asp Gly Ser 
                165                 170                 175     


Ala Ile Tyr Gly Ser Ser His Ser Trp Ser Asp Thr Leu Arg Ser Phe 
            180                 185                 190         


Ser Gly Gly Gln Leu Ala Ser Gly Pro Asp Pro Ala Phe Pro Ser Asp 
        195                 200                 205             


Ser Gln Ser Ser Leu Leu Met Trp Met Ala Pro Asp Pro Ser Thr Gly 
    210                 215                 220                 


Gln Gly Gly Pro Arg Gly Val Tyr Ala Phe Gly Ala Gln Arg Gly Asn 
225                 230                 235                 240 


Arg Glu Pro Phe Leu Gln Ala Leu Gly Leu Leu Trp Phe Arg Tyr His 
                245                 250                 255     


Asn Leu Cys Ala Arg Lys Leu Ala Gln Glu His Pro His Trp Gly Asp 
            260                 265                 270         


Glu Glu Leu Phe Gln His Ala Arg Lys Arg Val Ile Ala Thr Tyr Gln 
        275                 280                 285             


Asn Ile Ala Met Tyr Glu Trp Leu Pro Ser Phe Leu Lys Gln Thr Pro 
    290                 295                 300                 


Pro Glu Tyr Pro Gly Tyr Arg Pro Phe Leu Asp Pro Ser Ile Ser Pro 
305                 310                 315                 320 


Glu Phe Val Val Ala Ser Glu Gln Phe Leu Ser Thr Met Val Pro Ser 
                325                 330                 335     


Gly Val Tyr Met Arg Asn Ala Ser Cys His Phe Gln Gly Ile Pro Ser 
            340                 345                 350         


His Asn Ser Ser Val Ser Gly Ala Leu Arg Val Cys Asn Ser Tyr Trp 
        355                 360                 365             


Ser Arg Glu His Pro Lys Leu Gln Arg Ala Glu Asp Val Asp Ala Leu 
    370                 375                 380                 


Leu Leu Gly Met Ala Ser Gln Ile Ala Glu Arg Glu Asp His Val Val 
385                 390                 395                 400 


Val Glu Asp Met Gln Asp Phe Trp Pro Gly Pro Leu Lys Phe Ser Arg 
                405                 410                 415     


Thr Asp Tyr Leu Ala Ser Cys Leu Gln Arg Gly Arg Asp Leu Gly Leu 
            420                 425                 430         


Pro Ser Tyr Thr Lys Ala Arg Glu Ala Leu Gly Leu Ser Pro Ile Ser 
        435                 440                 445             


His Trp Gln Asp Ile Asn Pro Ala Leu Ser Arg Ser Asn Gly Thr Val 
    450                 455                 460                 


Leu Glu Ala Thr Ala Ala Leu Tyr Asn Gln Asp Leu Ser Arg Leu Glu 
465                 470                 475                 480 


Leu Leu Pro Gly Gly Leu Leu Glu Ser His Gly Asp Pro Gly Pro Leu 
                485                 490                 495     


Phe Ser Thr Ile Val Leu Asp Gln Phe Val Arg Leu Arg Asp Gly Asp 
            500                 505                 510         


Arg Tyr Trp Phe Glu Asn Thr Arg Asn Gly Leu Phe Ser Lys Glu Glu 
        515                 520                 525             


Ile Ala Glu Ile Arg Asn Thr Ser Leu Arg Asp Ile Leu Val Ala Val 
    530                 535                 540                 


Thr Asn Val Asp Pro Ser Ala Leu Gln Pro Asn Val Phe Phe Trp Leu 
545                 550                 555                 560 


Ala Gly Asp Pro Cys Pro Gln Pro Ser Gln Leu Ser Ala Lys Gly Leu 
                565                 570                 575     


Pro Ala Cys Ala Pro Leu Phe Ile Arg Asp Tyr Phe Glu Gly Ser Gly 
            580                 585                 590         


Phe Gly Phe Gly Leu Thr Ile Gly Thr Leu Cys Cys Phe Pro Leu Val 
        595                 600                 605             


Ser Leu Leu Ser Ala Trp Ile Val Ala Arg Leu Arg Lys Arg Asn Phe 
    610                 615                 620                 


Lys Arg Leu Gln Arg Gln Asp Arg Gln Ser Ile Met Ser Glu Lys Leu 
625                 630                 635                 640 


Val Gly Gly Val Glu Ala Leu Glu Trp Gln Gly Arg Asn Glu Pro Cys 
                645                 650                 655     


Arg Pro Val Leu Val His Leu Gln Pro Gly Gln Ile Arg Val Val Asp 
            660                 665                 670         


Gly Arg Leu Thr Val Leu Arg Thr Ile Gln Leu Arg Pro Pro Gln Gln 
        675                 680                 685             


Val Asn Leu Ile Leu Ser Ser Asn Arg Gly Arg Arg Thr Leu Leu Leu 
    690                 695                 700                 


Lys Ile Pro Lys Glu Tyr Asp Leu Val Leu Leu Phe Asn Met Glu Glu 
705                 710                 715                 720 


Glu Arg Gln Ala Leu Val Glu Asn Val Arg Gly Ala Leu Lys Glu Asn 
                725                 730                 735     


Gly Leu Ser Phe Gln Glu Trp Glu Leu Arg Glu Gln Glu Leu Met Arg 
            740                 745                 750         


Ala Ala Val Thr Arg Gln Gln Arg Gly His Leu Leu Glu Thr Phe Phe 
        755                 760                 765             


Arg His Leu Phe Ser Gln Val Leu Asp Ile Asn Gln Ala Asp Ala Gly 
    770                 775                 780                 


Thr Leu Pro Leu Asp Ser Ser Thr Lys Val Arg Glu Ala Leu Thr Cys 
785                 790                 795                 800 


Glu Leu Ser Arg Ala Glu Phe Ala Asp Ser Leu Gly Leu Lys Pro Gln 
                805                 810                 815     


Asp Met Phe Val Glu Ser Met Phe Ser Leu Ala Asp Lys Asp Gly Asn 
            820                 825                 830         


Gly Tyr Leu Ser Phe Arg Glu Phe Leu Asp Ile Leu Val Val Phe Met 
        835                 840                 845             


Lys Gly Ser Pro Glu Glu Lys Ser Arg Leu Met Phe Arg Met Tyr Asp 
    850                 855                 860                 


Phe Asp Gly Asn Gly Leu Ile Ser Lys Asp Glu Phe Ile Arg Met Leu 
865                 870                 875                 880 


Arg Ser Phe Ile Glu Ile Ser Asn Asn Cys Leu Ser Lys Ala Gln Leu 
                885                 890                 895     


Ala Glu Val Val Glu Ser Met Phe Arg Glu Ser Gly Phe Gln Asp Lys 
            900                 905                 910         


Glu Glu Leu Thr Trp Glu Asp Phe His Phe Met Leu Arg Asp His Asp 
        915                 920                 925             


Ser Asp Leu Arg Phe Thr Gln Leu Cys Val Lys Gly Val Glu Val Pro 
    930                 935                 940                 


Glu Val Ile Lys Asn Leu Cys Arg Arg Ala Ser Tyr Ile Ser Gln Glu 
945                 950                 955                 960 


Lys Ile Cys Pro Ser Pro Arg Met Ser Ala His Cys Ala Arg Asn Asn 
                965                 970                 975     


Met Lys Thr Ala Ser Ser Pro Gln Arg Leu Gln Cys Pro Met Asp Thr 
            980                 985                 990         


Asp Pro Pro Gln Glu Ile Arg Arg  Arg Phe Gly Lys Lys  Val Thr Ser 
        995                 1000                 1005             


Phe Gln  Pro Leu Leu Phe Thr  Glu Ala His Arg Glu  Lys Phe Gln 
    1010                 1015                 1020             


Arg Ser  Arg Arg His Gln Thr  Val Gln Gln Phe Lys  Arg Phe Ile 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Arg His Ile  Gly Cys Val Ala Val  Phe Tyr Thr 
    1040                 1045                 1050             


Ile Thr  Gly Ala Leu Phe Leu  Glu Arg Ala Tyr Tyr  Tyr Ala Phe 
    1055                 1060                 1065             


Ala Ala  His His Ser Gly Ile  Thr Asp Thr Thr Arg  Val Gly Ile 
    1070                 1075                 1080             


Ile Leu  Ser Arg Gly Thr Ala  Ala Ser Ile Ser Phe  Met Phe Ser 
    1085                 1090                 1095             


Tyr Ile  Leu Leu Thr Met Cys  Arg Asn Leu Ile Thr  Phe Leu Arg 
    1100                 1105                 1110             


Glu Thr  Phe Leu Asn Arg Tyr  Ile Pro Phe Asp Ala  Ala Val Asp 
    1115                 1120                 1125             


Phe His  Arg Leu Ile Ala Ser  Thr Ala Ile Ile Leu  Thr Val Leu 
    1130                 1135                 1140             


His Ser  Ala Gly His Val Val  Asn Val Tyr Leu Phe  Ser Ile Ser 
    1145                 1150                 1155             


Pro Leu  Ser Val Leu Ser Cys  Leu Phe Pro Gly Leu  Phe His Asp 
    1160                 1165                 1170             


Asp Gly  Ser Glu Phe Pro Gln  Lys Tyr Tyr Trp Trp  Phe Phe Gln 
    1175                 1180                 1185             


Thr Val  Pro Gly Leu Thr Gly  Val Leu Leu Leu Leu  Ala Leu Ala 
    1190                 1195                 1200             


Ile Met  Tyr Val Phe Ala Ser  His His Phe Arg Arg  Arg Ser Phe 
    1205                 1210                 1215             


Arg Gly  Phe Trp Leu Thr His  His Leu Tyr Ile Phe  Leu Tyr Ile 
    1220                 1225                 1230             


Leu Leu  Ile Ile His Gly Ser  Phe Ala Leu Ile Gln  Met Pro Arg 
    1235                 1240                 1245             


Phe His  Ile Phe Phe Leu Val  Pro Ala Ile Ile Tyr  Val Gly Asp 
    1250                 1255                 1260             


Lys Leu  Val Ser Leu Ser Arg  Lys Lys Val Glu Ile  Ser Val Val 
    1265                 1270                 1275             


Lys Ala  Glu Leu Leu Pro Ser  Gly Val Thr His Leu  Arg Phe Gln 
    1280                 1285                 1290             


Arg Pro  Gln Gly Phe Glu Tyr  Lys Ser Gly Gln Trp  Val Arg Ile 
    1295                 1300                 1305             


Ala Cys  Leu Ala Leu Gly Thr  Thr Glu Tyr His Pro  Phe Thr Leu 
    1310                 1315                 1320             


Thr Ser  Ala Pro His Glu Asp  Thr Leu Ser Leu His  Ile Arg Ala 
    1325                 1330                 1335             


Ala Gly  Pro Trp Thr Thr Arg  Leu Arg Glu Ile Tyr  Ser Pro Pro 
    1340                 1345                 1350             


Thr Gly  Asp Thr Cys Ala Arg  Tyr Pro Lys Leu Tyr  Leu Asp Gly 
    1355                 1360                 1365             


Pro Phe  Gly Glu Gly His Gln  Glu Trp His Lys Phe  Glu Val Ser 
    1370                 1375                 1380             


Val Leu  Val Gly Gly Gly Ile  Gly Val Thr Pro Phe  Ala Ser Ile 
    1385                 1390                 1395             


Leu Lys  Asp Leu Val Phe Lys  Ser Ser Val Ser Cys  Gln Val Phe 
    1400                 1405                 1410             


Cys Lys  Lys Ile Tyr Phe Ile  Trp Val Thr Arg Thr  Gln Arg Gln 
    1415                 1420                 1425             


Phe Glu  Trp Leu Ala Asp Ile  Ile Arg Glu Val Glu  Glu Asn Asp 
    1430                 1435                 1440             


Arg Gln  Asp Leu Val Ser Val  His Ile Tyr Ile Thr  Gln Leu Ala 
    1445                 1450                 1455             


Glu Lys  Phe Asp Leu Arg Thr  Thr Met Leu Tyr Ile  Cys Glu Arg 
    1460                 1465                 1470             


His Phe  Gln Lys Val Leu Asn  Arg Ser Leu Phe Thr  Gly Leu Arg 
    1475                 1480                 1485             


Ser Ile  Thr His Phe Gly Arg  Pro Pro Phe Glu Pro  Phe Phe Asn 
    1490                 1495                 1500             


Ser Leu  Gln Glu Val His Pro  Gln Val Arg Lys Ile  Gly Val Phe 
    1505                 1510                 1515             


Ser Cys  Gly Pro Pro Gly Met  Thr Lys Asn Val Glu  Lys Ala Cys 
    1520                 1525                 1530             


Gln Leu  Ile Asn Arg Gln Asp  Arg Thr His Phe Ser  His His Tyr 
    1535                 1540                 1545             


Glu Asn  Phe 
    1550     


<210>  6
<211>  2021
<212>  DNA
<213>  homo sapiens

<400>  6
gtgcttccag cggacggcag cgcgcgaggt gagacggcga gggctcccgg ggcgcaggta       60

gagatgttcc gtcggtgccg aaggcccggc tagtgcggtt gtgtggacgg cgaaaaaaac      120

caggccaggc gtcaaagcaa gtcacccatc cgacctaaac ccctctaaga ccccggagtc      180

acgtctccct ccggggatcc tcgtgaggtc ttgggggtcc caccgccctg cgagccgcgc      240

ccgcgccccg ccagacccgg aactgcgtcg ctagaacgtc gggacctggt tccctcttta      300

atcacacccc cgggggcgct tcgtgtgagg ttccacgggg gaaggcgaga ggcgcaggct      360

gccacacacg cactgtttgg aagaggggaa gcattgcccc ccctgcacca cctcaccaag      420

atggctactt tgggacacac attccccttc tatgctggcc ccaagccaac cttcccgatg      480

gacaccactt tggccagcat catcatgatc tttctgactg cactggccac gttcatcgtc      540

atcctgcctg gcattcgggg aaagacgagg ctgttctggc tgcttcgggt ggtgaccagc      600

ttattcatcg gggctgcaat cctggctgtg aatttcagtt ctgagtggtc tgtgggccag      660

gtcagcacca acacatcata caaggccttc agttctgagt ggatcagcgc tgatattggg      720

ctgcaggtcg ggctgggtgg agtcaacatc acactcacag ggacccccgt gcagcagctg      780

aatgagacca tcaattacaa cgaggagttc acctggcgcc tgggtgagaa ctatgctgag      840

gagtatgcaa aggctctgga gaaggggctg ccagaccctg tgttgtacct agctgagaag      900

ttcactccaa gaagcccatg tggcctatac cgccagtacc gcctggcggg acactacacc      960

tcagccatgc tatgggtggc attcctctgc tggctgctgg ccaatgtgat gctctccatg     1020

cctgtgctgg tatatggtgg ctacatgcta ttggccacgg gcatcttcca gctgttggct     1080

ctgctcttct tctccatggc cacatcactc acctcaccct gtcccctgca cctgggcgct     1140

tctgtgctgc atactcacca tgggcctgcc ttctggatca cattgaccac aggactgctg     1200

tgtgtgctgc tgggcctggc tatggcggtg gcccacagga tgcagcctca caggctgaag     1260

gctttcttca accagagtgt ggatgaagac cccatgctgg agtggagtcc tgaggaaggt     1320

ggactcctga gcccccgcta ccggtccatg gctgacagtc ccaagtccca ggacattccc     1380

ctgtcagagg cttcctccac caaggcatac tatcgcccca ggagactttc cctggtgcct     1440

gcggatgtcc gaggcctcgc gccagcagcg ctcagtgccc ttcctggagc tctcctggcc     1500

caggcctggc gggcactgct tcccggcctg cgatgtccca aggcggggaa ggagtccaga     1560

ttgggtcccc ctcacagtcc ttggcgcttt ggtccagaag ggtgcgaaga gcgctgggcc     1620

gaacatactg gagactcacc acggcccctc cgaggaagag gcacaggacg cctgtggcgg     1680

tggggatcga aagaaaggag ggcatgtgga gtcagggcta tgttgcccag gctggtctcg     1740

aactctggcc tcaaacgacc ttcctgcctc gacctcccaa agtgctggga ttacaggcgt     1800

gatgcccggg ccttcttcca tcttttggag cctacccctt gtgttacctc ccgccacaca     1860

cctctaatct gaattacatg aaacacggca agacaccaaa cccttctgag ccccccactt     1920

ttcatctgta aaatggtcat aacagtgcct gtttctgcga actattgaga ggggcaaata     1980

gggtaataga tgtgaattca ttctgtaaac tggaaagtgc a                         2021


<210>  7
<211>  1991
<212>  DNA
<213>  homo sapiens

<400>  7
gtgcttccag cggacggcag cgcgcgaggt gagacggcga gggctcccgg ggcgcagtcc       60

aaggccatcg atcacctgcc acccacagac caggccaggc gtcaaagcaa gtcacccatc      120

cgacctaaac ccctctaaga ccccggagtc acgtctccct ccggggatcc tcgtgaggtc      180

ttgggggtcc caccgccctg cgagccgcgc ccgcgccccg ccagacccgg aactgcgtcg      240

ctagaacgtc gggacctggt tccctcttta atcacacccc cgggggcgct tcgtgtgagg      300

ttccacgggg gaaggcgaga ggcgcaggct gccacacacg cactgtttgg aagaggggaa      360

gcattgcccc ccctgcacca cctcaccaag atggctactt tgggacacac attccccttc      420

tatgctggcc ccaagccaac cttcccgatg gacaccactt tggccagcat catcatgatc      480

tttctgactg cactggccac gttcatcgtc atcctgcctg gcattcgggg aaagacgagg      540

ctgttctggc tgcttcgggt ggtgaccagc ttattcatcg gggctgcaat cctggctgtg      600

aatttcagtt ctgagtggtc tgtgggccag gtcagcacca acacatcata caaggccttc      660

agttctgagt ggatcagcgc tgatattggg ctgcaggtcg ggctgggtgg agtcaacatc      720

acactcacag ggacccccgt gcagcagctg aatgagacca tcaattacaa cgaggagttc      780

acctggcgcc tgggtgagaa ctatgctgag gagtatgcaa aggctctgga gaaggggctg      840

ccagaccctg tgttgtacct agctgagaag ttcactccaa gaagcccatg tggcctatac      900

cgccagtacc gcctggcggg acactacacc tcagccatgc tatgggtggc attcctctgc      960

tggctgctgg ccaatgtgat gctctccatg cctgtgctgg tatatggtgg ctacatgcta     1020

ttggccacgg gcatcttcca gctgttggct ctgctcttct tctccatggc cacatcactc     1080

acctcaccct gtcccctgca cctgggcgct tctgtgctgc atactcacca tgggcctgcc     1140

ttctggatca cattgaccac aggactgctg tgtgtgctgc tgggcctggc tatggcggtg     1200

gcccacagga tgcagcctca caggctgaag gctttcttca accagagtgt ggatgaagac     1260

cccatgctgg agtggagtcc tgaggaaggt ggactcctga gcccccgcta ccggtccatg     1320

gctgacagtc ccaagtccca ggacattccc ctgtcagagg cttcctccac caaggcatac     1380

tatcgcccca ggagactttc cctggtgcct gcggatgtcc gaggcctcgc gccagcagcg     1440

ctcagtgccc ttcctggagc tctcctggcc caggcctggc gggcactgct tcccggcctg     1500

cgatgtccca aggcggggaa ggagtccaga ttgggtcccc ctcacagtcc ttggcgcttt     1560

ggtccagaag ggtgcgaaga gcgctgggcc gaacatactg gagactcacc acggcccctc     1620

cgaggaagag gcacaggacg cctgtggcgg tggggatcga aagaaaggag ggcatgtgga     1680

gtcagggcta tgttgcccag gctggtctcg aactctggcc tcaaacgacc ttcctgcctc     1740

gacctcccaa agtgctggga ttacaggcgt gatgcccggg ccttcttcca tcttttggag     1800

cctacccctt gtgttacctc ccgccacaca cctctaatct gaattacatg aaacacggca     1860

agacaccaaa cccttctgag ccccccactt ttcatctgta aaatggtcat aacagtgcct     1920

gtttctgcga actattgaga ggggcaaata gggtaataga tgtgaattca ttctgtaaac     1980

tggaaagtgc a                                                          1991


<210>  8
<211>  1512
<212>  DNA
<213>  homo sapiens

<400>  8
cattgccccc cctgcaccac ctcaccaaga tggctacttt gggacacaca ttccccttct       60

atgctggccc caagccaacc ttcccgatgg acaccacttt ggccagcatc atcatgatct      120

ttctgactgc actggccacg ttcatcgtca tcctgcctgg cattcgggga aagacgaggc      180

tgttctggct gcttcgggtg gtgaccagct tattcatcgg ggctgcaatc ctggggaccc      240

ccgtgcagca gctgaatgag accatcaatt acaacgagga gttcacctgg cgcctgggtg      300

agaactatgc tgaggagtat gcaaaggctc tggagaaggg gctgccagac cctgtgttgt      360

acctagctga gaagttcact ccaagaagcc catgtggcct ataccgccag taccgcctgg      420

cgggacacta cacctcagcc atgctatggg tggcattcct ctgctggctg ctggccaatg      480

tgatgctctc catgcctgtg ctggtatatg gtggctacat gctattggcc acgggcatct      540

tccagctgtt ggctctgctc ttcttctcca tggccacatc actcacctca ccctgtcccc      600

tgcacctggg cgcttctgtg ctgcatactc accatgggcc tgccttctgg atcacattga      660

ccacaggact gctgtgtgtg ctgctgggcc tggctatggc ggtggcccac aggatgcagc      720

ctcacaggct gaaggctttc ttcaaccaga gtgtggatga agaccccatg ctggagtgga      780

gtcctgagga aggtggactc ctgagccccc gctaccggtc catggctgac agtcccaagt      840

cccaggacat tcccctgtca gaggcttcct ccaccaaggc atactatcgc cccaggagac      900

tttccctggt gcctgcggat gtccgaggcc tcgcgccagc agcgctcagt gcccttcctg      960

gagctctcct ggcccaggcc tggcgggcac tgcttcccgg cctgcgatgt cccaaggcgg     1020

ggaaggagtc cagattgggt ccccctcaca gtccttggcg ctttggtcca gaagggtgcg     1080

aagagcgctg ggccgaacat actggagact caccacggcc cctccgagga agaggcacag     1140

gacgcctgtg gcggtgggga tcgaaagaaa ggagggcatg tggagtcagg gctatgttgc     1200

ccaggctggt ctcgaactct ggcctcaaac gaccttcctg cctcgacctc ccaaagtgct     1260

gggattacag gcgtgatgcc cgggccttct tccatctttt ggagcctacc ccttgtgtta     1320

cctcccgcca cacacctcta atctgaatta catgaaacac ggcaagacac caaacccttc     1380

tgagcccccc acttttcatc tgtaaaatgg tcataacagt gcctgtttct gcgaactatt     1440

gagaggggca aatagggtaa tagatgtgaa ttcattctgt aaactggaaa gtgcaaaaaa     1500

aaaaaaaaaa aa                                                         1512


<210>  9
<211>  1111
<212>  DNA
<213>  homo sapiens

<400>  9
cattgccccc cctgcaccac ctcaccaaga tggctacttt gggacacaca ttccccttct       60

atgctggccc caagccaacc ttcccgatgg acaccacttt ggccagcatc atcatgatct      120

ttctgactgc actggccacg ttcatcgtca tcctgcctgg cattcgggga aagacgaggc      180

tgttctggct gcttcgggtg gtgaccagct tattcatcgg ggctgcaatc ctggctgtga      240

atttcagttc tgagtggtct gtgggccagg tcagcaccaa cacatcatac aaggccttca      300

gttctgagtg gatcagcgct gatattgggc tgcaggtcgg gctgggtgga gtcaacatca      360

cactcacagg gacccccgtg cagcagctga atgagaccat caattacaac gaggagttca      420

cctggcgcct gggtgagaac tatgctgagg agtatgcaaa ggctctggag aaggggctgc      480

cagaccctgt gttgtaccta gctgagaagt tcactccaag aagcccatgt ggcctatacc      540

gccagtaccg cctggcggga cactacacct cagccatgct atgggtggca ttcctctgct      600

ggctgctggc caatgtgatg ctctccatgc ctgtgctggt atatggtggc tacatgctat      660

tggccacggg catcttccag ctgttggctc tgctcttctt ctccatggcc acatcactca      720

cctcaccctg tcccctgcac ctgggcgctt ctgtgctgca tactcaccat gggcctgcct      780

tctggatcac attgaccaca ggactgctgt gtgtgctgct gggcctggct atggcggtgg      840

cccacaggat gcagcctcac aggctgaagg ctttcttcaa ccagagtgtg gatgaagacc      900

ccatgctgga gtggagtcct gaggaaggtg gactcctgag cccccgctac cggtccatgg      960

ctgacagtcc caagtcccag gacattcccc tgtcagaggc ttcctccacc aaggcatact     1020

gtaaggaggc acaccccaaa gatcctgatt gtgctttata acattcctcc ccgtggaggc     1080

cacctggact tccaaaaaaa aaaaaaaaaa a                                    1111


<210>  10
<211>  3035
<212>  DNA
<213>  homo sapiens

<400>  10
gtgcttccag cggacggcag cgcgcgagac caggccaggc gtcaaagcaa gtcacccatc       60

cgacctaaac ccctctaaga ccccggagtc acgtctccct ccggggatcc tcgtgaggtc      120

ttgggggtcc caccgccctg cgagccgcgc ccgcgccccg ccagacccgg aactgcgtcg      180

ctagaacgtc gggacctggt tccctcttta atcacacccc cgggggcgct tcgtgtgagg      240

ttccacgggg gaaggcgaga ggcgcaggct gccacacacg cactgtttgg aagaggggaa      300

gggctgcact tcctgctttc atccagacca agttcggatc aagtgggagt tcttcaaaga      360

gagagtttgc attgcccccc ctgcaccacc tcaccaagat ggctactttg ggacacacat      420

tccccttcta tgctggcccc aagccaacct tcccgatgga caccactttg gccagcatca      480

tcatgatctt tctgactgca ctggccacgt tcatcgtcat cctgcctggc attcggggaa      540

agacgaggct gttctggctg cttcgggtgg tgaccagctt attcatcggg gctgcaatcc      600

tggggacccc cgtgcagcag ctgaatgaga ccatcaatta caacgaggag ttcacctggc      660

gcctgggtga gaactatgct gaggagtatg caaaggctct ggagaagggg ctgccagacc      720

ctgtgttgta cctagctgag aagttcactc caagaagccc atgtggccta taccgccagt      780

accgcctggc gggacactac acctcagcca tgctatgggt ggcattcctc tgctggctgc      840

tggccaatgt gatgctctcc atgcctgtgc tggtatatgg tggctacatg ctattggcca      900

cgggcatctt ccagctgttg gctctgctct tcttctccat ggccacatca ctcacctcac      960

cctgtcccct gcacctgggc gcttctgtgc tgcatactca ccatgggcct gccttctgga     1020

tcacattgac cacaggactg ctgtgtgtgc tgctgggcct ggctatggcg gtggcccaca     1080

ggatgcagcc tcacaggctg aaggctttct tcaaccagag tgtggatgaa gaccccatgc     1140

tggagtggag tcctgaggaa ggtggactcc tgagcccccg ctaccggtcc atggctgaca     1200

gtcccaagtc ccaggacatt cccctgtcag aggcttcctc caccaaggca tactgtaagg     1260

aggcacaccc caaagatcct gattgtgctt tataacattc ctccccgtgg aggccacctg     1320

gacttccagt ctggctccaa acctcattgg cgccccataa aaccagcaga actgccctca     1380

gggtggctgt taccagacac ccagcaccaa tctacagacg gagtagaaaa aggaggctct     1440

atatactgat gttaaaaaac aaaacaaaac aaaaagccct aagggactga agagatgctg     1500

ggcctgtcca taaagcctgt tgccatgata aggccaagca ggggctagct tatctgcaca     1560

gcaacccagc ctttccgtgc tgccttgcct cttcaagatg ctattcactg aaacctaact     1620

tcacccccat aacaccagca gggtgggggt tacatatgat tctcctatgg tttcctctca     1680

tccctcggca cctcttgttt tcctttttcc tgggttcctt ttgttcttcc tttacttctc     1740

cagcttgtgt ggccttttgg tacaatgaaa gacagcactg gaaaggaggg gaaaccaaac     1800

ttctcatcct aggtctaaca ttaaccaact atgccacatt ctctttgagc ttcagttccc     1860

aaatttgcta cataagattg caagacttgc caagaatctt gggatttatc tttctatgcc     1920

ttgctgacac ctaccttggc cctcaaacac cacctcacaa gaagccaggt gggaagttag     1980

ggaatcaact ccaaaacgct attccttccc accccactca gctgggctag ctgagtggca     2040

tccaggacgg gggagtgggt gacctgcctc atcactgcca cctaacgtcc ccctggggtg     2100

gttcagaaag atgctagctc tggtagggtc cctccggcct cactagaggg cgcccctatt     2160

actctggagt cgacgcagag aatcaggttt cacagcactg cggagagtgt actaggctgt     2220

ctccagccca gcgaagctca tgaggacgtg cgaccccggc gcggagaagc catgaaaatt     2280

aatgggaaaa acagttttta aaaaacaaaa gaaaaaaagg tttatttaca gatcgcccca     2340

ggagactttc cctggtgcct gcggatgtcc gaggcctcgc gccagcagcg ctcagtgccc     2400

ttcctggagc tctcctggcc caggcctggc gggcactgct tcccggcctg cgatgtccca     2460

aggcggggaa ggagtccaga ttgggtcccc ctcacaggtt agtggtgata cattttaagt     2520

ctgggagagc ggcctgcttg tgcagtgggt cgccgaggat aagaggtgag ccccctctct     2580

cctggctgca gtccttggcg ctttggtcca gaagggtgcg aagagcgctg ggccgaacat     2640

actggagact caccacggcc cctccgagga agaggcacag gacgcctgtg gcggtgggga     2700

tcgaaagaaa ggagggcatg tggagtcagg gctatgttgc ccaggctggt ctcgaactct     2760

ggcctcaaac gaccttcctg cctcgacctc ccaaagtgct gggattacag gcgtgatgcc     2820

cgggccttct tccatctttt ggagcctacc ccttgtgtta cctcccgcca cacacctcta     2880

atctgaatta catgaaacac ggcaagacac caaacccttc tgagcccccc acttttcatc     2940

tgtaaaatgg tcataacagt gcctgtttct gcgaactatt gagaggggca aatagggtaa     3000

tagatgtgaa ttcattctgt aaactggaaa gtgca                                3035


<210>  11
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  sense strand DUOX1 primer

<400>  11
ggaacggucu cauuuccaat t                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  antisense strand DUOX1 primer

<400>  12
uuggaaauga gaccguuccc a                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  sense strand DUOX1 primer

<400>  13
cgauuugaug gaugguauat t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  antisense strand DUOX1 primer


<220>
<221>  misc_feature
<223>  antisense strand DUOX1 primer

<400>  14
uauaccaucc aucaaaucgc t                                                 21


