                         SEQUENCE LISTING

<110>  University of Pittsburgh - Of the Commonwealth System of 
       Higher Education
 
<120>  METHODS OF RESTORING LYSOSOMAL FUNCTION OF RETINAL PIGMENT 
       EPITHELIAL CELLS BY ACTIVATION OF TFEB

<130>  748077

<150>  US 62/897,800
<151>  2019-09-09

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Ala Ser Arg Ile Gly Leu Arg Met Gln Leu Met Arg Glu Gln Ala 
1               5                   10                  15      


Gln Gln Glu Glu Gln Arg Glu Arg Met Gln Gln Gln Ala Val Met His 
            20                  25                  30          


Tyr Met Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Gly Gly Pro 
        35                  40                  45              


Pro Thr Pro Ala Ile Asn Thr Pro Val His Phe Gln Ser Pro Pro Pro 
    50                  55                  60                  


Val Pro Gly Glu Val Leu Lys Val Gln Ser Tyr Leu Glu Asn Pro Thr 
65                  70                  75                  80  


Ser Tyr His Leu Gln Gln Ser Gln His Gln Lys Val Arg Glu Tyr Leu 
                85                  90                  95      


Ser Glu Thr Tyr Gly Asn Lys Phe Ala Ala His Ile Ser Pro Ala Gln 
            100                 105                 110         


Gly Ser Pro Lys Pro Pro Pro Ala Ala Ser Pro Gly Val Arg Ala Gly 
        115                 120                 125             


His Val Leu Ser Ser Ser Ala Gly Asn Ser Ala Pro Asn Ser Pro Met 
    130                 135                 140                 


Ala Met Leu His Ile Gly Ser Asn Pro Glu Arg Glu Leu Asp Asp Val 
145                 150                 155                 160 


Ile Asp Asn Ile Met Arg Leu Asp Asp Val Leu Gly Tyr Ile Asn Pro 
                165                 170                 175     


Glu Met Gln Met Pro Asn Thr Leu Pro Leu Ser Ser Ser His Leu Asn 
            180                 185                 190         


Val Tyr Ser Ser Asp Pro Gln Val Thr Ala Ser Leu Val Gly Val Thr 
        195                 200                 205             


Ser Ser Ser Cys Pro Ala Asp Leu Thr Gln Lys Arg Glu Leu Thr Asp 
    210                 215                 220                 


Ala Glu Ser Arg Ala Leu Ala Lys Glu Arg Gln Lys Lys Asp Asn His 
225                 230                 235                 240 


Asn Leu Ile Glu Arg Arg Arg Arg Phe Asn Ile Asn Asp Arg Ile Lys 
                245                 250                 255     


Glu Leu Gly Met Leu Ile Pro Lys Ala Asn Asp Leu Asp Val Arg Trp 
            260                 265                 270         


Asn Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Arg Met 
        275                 280                 285             


Gln Lys Asp Leu Gln Lys Ser Arg Glu Leu Glu Asn His Ser Arg Arg 
    290                 295                 300                 


Leu Glu Met Thr Asn Lys Gln Leu Trp Leu Arg Ile Gln Glu Leu Glu 
305                 310                 315                 320 


Met Gln Ala Arg Val His Gly Leu Pro Thr Thr Ser Pro Ser Gly Met 
                325                 330                 335     


Asn Met Ala Glu Leu Ala Gln Gln Val Val Lys Gln Glu Leu Pro Ser 
            340                 345                 350         


Glu Glu Gly Pro Gly Glu Ala Leu Met Leu Gly Ala Glu Val Pro Asp 
        355                 360                 365             


Pro Glu Pro Leu Pro Ala Leu Pro Pro Gln Ala Pro Leu Pro Leu Pro 
    370                 375                 380                 


Thr Gln Pro Pro Ser Pro Phe His His Leu Asp Phe Ser His Ser Leu 
385                 390                 395                 400 


Ser Phe Gly Gly Arg Glu Asp Glu Gly Pro Pro Gly Tyr Pro Glu Pro 
                405                 410                 415     


Leu Ala Pro Gly His Gly Ser Pro Phe Pro Ser Leu Ser Lys Lys Asp 
            420                 425                 430         


Leu Asp Leu Met Leu Leu Asp Asp Ser Leu Leu Pro Leu Ala Ser Asp 
        435                 440                 445             


Pro Leu Leu Ser Thr Met Ser Pro Glu Ala Ser Lys Ala Ser Ser Arg 
    450                 455                 460                 


Arg Ser Ser Phe Ser Met Glu Glu Gly Asp Val Leu 
465                 470                 475     


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
atggcgtcac gcatcggg                                                     18


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
tcacagaaca tcaccctcct                                                   20


<210>  4
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
accagcctag tcgccagacc accgggccac catggcgtca cgcatcggg                   49


<210>  5
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
cacagtcgag gctgatcagc gagcttcaca gaacatcacc ctcct                       45


