<110>    Kyungpook National University Industry-Academic Cooperation Foundation

<120>    Antibody for detecting acetylation of cyclooxygenase 2 and uses
         thereof

<130>    OP20-0059/PCT

<150>    KR 10-2019-0116290
<151>    2019-09-20

<160>    46

<170>    KoPatentIn 3.0

<210>    1
<211>    604
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    human cyclooxygenase 2 protein


<400>    1
Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His
  1               5                  10                  15 

Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys
             20                  25                  30 

Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly
         35                  40                  45 

Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys
     50                  55                  60 

Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His
 65                  70                  75                  80 

Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn
                 85                  90                  95 

Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser
            100                 105                 110 

Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe
        115                 120                 125 

Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp
    130                 135                 140 

Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser
145                 150                 155                 160 

Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp
                165                 170                 175 

Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr
            180                 185                 190 

His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn
        195                 200                 205 

Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu
    210                 215                 220 

Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr
225                 230                 235                 240 

Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln
                245                 250                 255 

Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala
            260                 265                 270 

Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala
        275                 280                 285 

Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln
    290                 295                 300 

Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu
305                 310                 315                 320 

Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln
                325                 330                 335 

His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu
            340                 345                 350 

Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn
        355                 360                 365 

Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His
    370                 375                 380 

Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu
385                 390                 395                 400 

Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile
                405                 410                 415 

Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys
            420                 425                 430 

Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser
        435                 440                 445 

Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe
    450                 455                 460 

Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu
465                 470                 475                 480 

Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu
                485                 490                 495 

Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly
            500                 505                 510 

Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro
        515                 520                 525 

Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile
    530                 535                 540 

Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly
545                 550                 555                 560 

Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr
                565                 570                 575 

Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn
            580                 585                 590 

Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu
        595                 600                


<210>    2
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Epitope for S565 acetylated COX-2


<220>
<221>    MISC_FEATURE
<222>    (4)
<223>    The X at position 4 is an acetylated serine


<400>    2
Pro Phe Thr Xaa Phe Ser Val Pro Asp
  1               5                


<210>    3
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Epitope for S565 acetylated COX-2


<220>
<221>    MISC_FEATURE
<222>    (4)
<223>    The X at position 4 is an acetylated serine


<400>    3
Pro Phe Thr Xaa Phe Ser Val Pro Asp Pro Glu Leu Ile
  1               5                  10            


<210>    4
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Epitope for S565 acetylated COX-2


<220>
<221>    MISC_FEATURE
<222>    (6)
<223>    The X at position 6 is an acetylated serine


<400>    4
Gly Cys Pro Phe Thr Xaa Phe Ser Val Pro Asp
  1               5                  10    


<210>    5
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-L1 of 9F7-2


<400>    5
Arg Ser Ser Gln Ser Ile Val His Arg Asn Gly Phe Thr Tyr Leu Glu
  1               5                  10                  15 




<210>    6
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-L2 of 9F7-2


<400>    6
Gln Val Ser Asn Arg Phe Ser
  1               5        


<210>    7
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-L3 of 9F7-2


<400>    7
Phe Gln Gly Ser His Val Pro Pro Thr
  1               5                


<210>    8
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-H1 of 9F7-2


<400>    8
Asp Tyr Leu Leu Gly
  1               5


<210>    9
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-H2 of 9F7-2


<400>    9
Asp Ile Tyr Pro Gly Gly Thr Tyr Ile Lys Tyr Asn Glu Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    10
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-H3 of 9F7-2


<400>    10
Gly Arg Asn Asp Glu Lys Gly Asp Tyr
  1               5                


<210>    11
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of 9F7-2


<400>    11
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
  1               5                  10                  15 

Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Arg
             20                  25                  30 

Asn Gly Phe Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Lys Leu Leu Ile Tyr Gln Val Ser Asn Arg Phe Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                 85                  90                  95 

Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110 




<210>    12
<211>    118
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of 9F7-2


<400>    12
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr
  1               5                  10                  15 

Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
             20                  25                  30 

Leu Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Asp Ile Tyr Pro Gly Gly Thr Tyr Ile Lys Tyr Asn Glu Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                 85                  90                  95 

Ala Arg Gly Arg Asn Asp Glu Lys Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110 

Ser Val Thr Val Ser Ser
        115            


<210>    13
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-L1 of 9F7-2


<400>    13
agatctagtc agagcattgt acatcgtaat ggattcacct acttagaa                      48


<210>    14
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-L2 of 9F7-2


<400>    14
caagtttcca accgattttc t                                                   21


<210>    15
<211>    27
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-L3 of 9F7-2


<400>    15
tttcagggtt cacatgttcc tccgaca                                             27


<210>    16
<211>    15
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-H1 of 9F7-2


<400>    16
gactacttac taggt                                                          15


<210>    17
<211>    51
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-H2 of 9F7-2


<400>    17
gatatttacc ctggaggtac ttatattaag tacaatgaga agttcaaggg c                  51


<210>    18
<211>    27
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-H3 of 9F7-2


<400>    18
gggaggaacg acgagaaggg ggactac                                             27


<210>    19
<211>    336
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of 9F7-2


<400>    19
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc         60

atctcttgca gatctagtca gagcattgta catcgtaatg gattcaccta cttagaatgg        120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct accaagtttc caaccgattt        180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc        240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcagggttc acatgttcct        300

ccgacattcg gtggaggcac caagctggaa atcaaa                                  336


<210>    20
<211>    354
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of 9F7-2


<400>    20
caggtccagc tgcagcagtc tggagctgag ctggtaagac ctgggacttc agtgaagata         60

tcctgcaagg cttctggcta caccttcact gactacttac taggttgggt aaagcagagg        120

cctggacatg gacttgagtg gattggagat atttaccctg gaggtactta tattaagtac        180

aatgagaagt tcaagggcaa ggccacactg actgcagaca catcctccag cactgcctac        240

atgcaactca gtagcctgac atctgaggac tctgctgtct acttctgtgc aagagggagg        300

aacgacgaga agggggacta ctggggtcaa ggaacctcag tcaccgtctc ctca              354


<210>    21
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-L1 of 44C7C8


<400>    21
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu
  1               5                  10                  15 

Ala
   


<210>    22
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-L2 of 44C7C8


<400>    22
Trp Ala Ser Thr Arg Glu Ser
  1               5        


<210>    23
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-L3 of 44C7C8


<400>    23
Gln Gln Tyr Tyr Thr Tyr Pro Phe Thr
  1               5                


<210>    24
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-H1 of 44C7C8


<400>    24
Ser Gly Tyr Tyr Trp Asn
  1               5    


<210>    25
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-H2 of 44C7C8


<400>    25
Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn
  1               5                  10                  15 




<210>    26
<211>    14
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR-H3 of 44C7C8


<400>    26
Gly Ala Asp Tyr Tyr Gly Asn Thr Tyr Phe Tyr Phe Asp Val
  1               5                  10                


<210>    27
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of 44C7C8


<400>    27
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Glu
  1               5                  10                  15 

Glu Lys Val Asn Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser
             20                  25                  30 

Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
     50                  55                  60 

Pro Asp Arg Phe Thr Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
                 85                  90                  95 

Tyr Tyr Thr Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile
            100                 105                 110 

Lys
   


<210>    28
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of 44C7C8


<400>    28
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
  1               5                  10                  15 

Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly
             20                  25                  30 

Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
         35                  40                  45 

Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu
     50                  55                  60 

Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Tyr Lys Lys Gln Phe Phe
 65                  70                  75                  80 

Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Gly Ala Asp Tyr Tyr Gly Asn Thr Tyr Phe Tyr Phe Asp Val
            100                 105                 110 

Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
        115                 120            


<210>    29
<211>    51
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-L1 of 44C7C8


<400>    29
aagtccagtc agagcctttt atatagtaga aatcaaaaga actacttggc c                  51


<210>    30
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-L2 of 44C7C8


<400>    30
tgggcatcca ctagggaatc t                                                   21


<210>    31
<211>    27
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-L3 of 44C7C8


<400>    31
cagcaatatt atacctatcc attcacg                                             27


<210>    32
<211>    15
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-H1 of 44C7C8


<400>    32
gactacttac taggt                                                          15


<210>    33
<211>    51
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-H2 of 44C7C8


<400>    33
gatatttacc ctggaggtac ttatattaag tacaatgaga agttcaaggg c                  51


<210>    34
<211>    27
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR-H3 of 44C7C8


<400>    34
gggaggaacg acgagaaggg ggactac                                             27


<210>    35
<211>    339
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of 44C7C8


<400>    35
gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttgaaga gaaggttaat         60

atgagctgca agtccagtca gagcctttta tatagtagaa atcaaaagaa ctacttggcc        120

tggtaccagc agaaaccagg gcagtctcct aaactactga tttactgggc atccactagg        180

gaatctgggg tccctgatcg cttcacaggc agtggagctg ggacagattt cactctcacc        240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatacctat        300

ccattcacgt tcggctcggg gacaaagttg gaaataaaa                               339


<210>    36
<211>    369
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of 44C7C8


<400>    36
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc         60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag        120

tttccaggaa acaaactgga atggatgggc tacataagct acgacggtag caataactac        180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catataagaa gcagtttttc        240

ctgaagttga attctgtgac tactgaggac acagccacat attactgtgc aaggggggct        300

gattactacg gtaataccta cttctacttc gatgtctggg gcgcagggac cacggtcacc        360

gtctcctca                                                                369


<210>    37
<211>    393
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Light chain variable region(9F7-2)


<400>    37
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagatgtgat         60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc        120

tcttgcagat ctagtcagag cattgtacat cgtaatggat tcacctactt agaatggtac        180

ctgcagaaac caggccagtc tccaaagctc ctgatctacc aagtttccaa ccgattttct        240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc        300

agagtggagg ctgaggatct gggagtttat tactgctttc agggttcaca tgttcctccg        360

acattcggtg gaggcaccaa gctggaaatc aaa                                     393


<210>    38
<211>    131
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region(9F7-2)


<400>    38
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala
  1               5                  10                  15 

Ser Arg Cys Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val
             20                  25                  30 

Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile
         35                  40                  45 

Val His Arg Asn Gly Phe Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro
     50                  55                  60 

Gly Gln Ser Pro Lys Leu Leu Ile Tyr Gln Val Ser Asn Arg Phe Ser
 65                  70                  75                  80 

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                 85                  90                  95 

Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys
            100                 105                 110 

Phe Gln Gly Ser His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125 

Glu Ile Lys
    130    


<210>    39
<211>    411
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region(9F7-2)


<400>    39
atggaatgga gcggggtctt tatctttctc ttgtcagtca ctgcagatgt ccactcccag         60

gtccagctgc agcagtctgg agctgagctg gtaagacctg ggacttcagt gaagatatcc        120

tgcaaggctt ctggctacac cttcactgac tacttactag gttgggtaaa gcagaggcct        180

ggacatggac ttgagtggat tggagatatt taccctggag gtacttatat taagtacaat        240

gagaagttca agggcaaggc cacactgact gcagacacat cctccagcac tgcctacatg        300

caactcagta gcctgacatc tgaggactct gctgtctact tctgtgcaag agggaggaac        360

gacgagaagg gggactactg gggtcaagga acctcagtca ccgtctcctc a                 411


<210>    40
<211>    137
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region(9F7-2)


<400>    40
Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Asp
  1               5                  10                  15 

Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
             20                  25                  30 

Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe
         35                  40                  45 

Thr Asp Tyr Leu Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu
     50                  55                  60 

Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Thr Tyr Ile Lys Tyr Asn
 65                  70                  75                  80 

Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser
                 85                  90                  95 

Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
            100                 105                 110 

Tyr Phe Cys Ala Arg Gly Arg Asn Asp Glu Lys Gly Asp Tyr Trp Gly
        115                 120                 125 

Gln Gly Thr Ser Val Thr Val Ser Ser
    130                 135        


<210>    41
<211>    399
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Light chain variable region(44C7C8)


<400>    41
atggattcac aggcccaggt tcttatgtta ctgctgctat gggtatctgg tacctgtggg         60

gacattgtga tgtcacagtc tccatcctcc ctagctgtgt cagttgaaga gaaggttaat        120

atgagctgca agtccagtca gagcctttta tatagtagaa atcaaaagaa ctacttggcc        180

tggtaccagc agaaaccagg gcagtctcct aaactactga tttactgggc atccactagg        240

gaatctgggg tccctgatcg cttcacaggc agtggagctg ggacagattt cactctcacc        300

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatacctat        360

ccattcacgt tcggctcggg gacaaagttg gaaataaaa                               399


<210>    42
<211>    133
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region(44C7C8)


<400>    42
Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser
  1               5                  10                  15 

Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala
             20                  25                  30 

Val Ser Val Glu Glu Lys Val Asn Met Ser Cys Lys Ser Ser Gln Ser
         35                  40                  45 

Leu Leu Tyr Ser Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln
     50                  55                  60 

Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg
 65                  70                  75                  80 

Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ala Gly Thr Asp
                 85                  90                  95 

Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr
            100                 105                 110 

Tyr Cys Gln Gln Tyr Tyr Thr Tyr Pro Phe Thr Phe Gly Ser Gly Thr
        115                 120                 125 

Lys Leu Glu Ile Lys
    130            


<210>    43
<211>    423
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region(44C7C8)


<400>    43
atgaaagtgt tgagtctgtt gtacctgttg acagccattc ctggtatcct gtctgatgta         60

cagcttcagg agtcaggacc tggcctcgtg aaaccttctc agtctctgtc tctcacctgc        120

tctgtcactg gctactccat caccagtggt tattactgga actggatccg gcagtttcca        180

ggaaacaaac tggaatggat gggctacata agctacgacg gtagcaataa ctacaaccca        240

tctctcaaaa atcgaatctc catcactcgt gacacatata agaagcagtt tttcctgaag        300

ttgaattctg tgactactga ggacacagcc acatattact gtgcaagggg ggctgattac        360

tacggtaata cctacttcta cttcgatgtc tggggcgcag ggaccacggt caccgtctcc        420

tca                                                                      423


<210>    44
<211>    141
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region(44C7C8)


<400>    44
Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile
  1               5                  10                  15 

Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro
             20                  25                  30 

Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr
         35                  40                  45 

Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu
     50                  55                  60 

Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro
 65                  70                  75                  80 

Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Tyr Lys Lys Gln
                 85                  90                  95 

Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr
            100                 105                 110 

Tyr Cys Ala Arg Gly Ala Asp Tyr Tyr Gly Asn Thr Tyr Phe Tyr Phe
        115                 120                 125 

Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser
    130                 135                 140 




<210>    45
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Control of epitope for COX-2 1


<400>    45
Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile
  1               5                  10            


<210>    46
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Control of epitope for COX-2 2


<400>    46
Gly Cys Pro Phe Thr Ser Phe Ser Val Pro Asp
  1               5                  10    
