                         SEQUENCE LISTING

<110>  REGENTS OF THE UNIVERSITY OF MINNESOTA
       GT BIOPHARMA, INC.
       Vallera, Daniel  A.
       Miller, Jeffrey S.
       Felices, Martin
       Schroeder, Martin
 
<120>  IMMUNOTHERAPY COMPOUNDS AND METHODS

<130>  0110.000632WO01

<150>  US 62/901,198
<151>  2019-09-16

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  501
<212>  PRT
<213>  Artificial

<220>
<223>  cam1615HER2

<400>  1

Met Glu Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser 
            20                  25                  30          


Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Ala Val Ala Ser Ile Thr Trp Ser Gly Arg Asp Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asn Pro Trp Pro Val Ala Ala Pro Arg Ser Gly Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Pro Ser Gly Gln 
        115                 120                 125             


Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
    130                 135                 140                 


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
145                 150                 155                 160 


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
                165                 170                 175     


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
            180                 185                 190         


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
        195                 200                 205             


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
    210                 215                 220                 


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
225                 230                 235                 240 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
                245                 250                 255     


Thr Ser Glu Ala Ser Gly Gly Pro Glu Asp Val Gln Leu Thr Gln Ser 
            260                 265                 270         


Pro Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
        275                 280                 285             


Arg Ala Thr Pro Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
    290                 295                 300                 


Gly Ser Ser Pro Lys Pro Trp Ile Tyr Thr Thr Ser Asn Leu Ala Ser 
305                 310                 315                 320 


Gly Val Pro Ala Arg Phe Ser Gly Gly Gly Ser Gly Thr Ser Tyr Ser 
                325                 330                 335     


Leu Thr Val Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Gln Gln Trp Ser Arg Ser Pro Pro Thr Phe Gly Gly Gly Ser Lys Leu 
        355                 360                 365             


Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys 
    370                 375                 380                 


Gly Val Gln Leu Gln Glu Ser Gly Pro Glu Val Val Lys Pro Gly Gly 
385                 390                 395                 400 


Ser Met Lys Ile Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Gly His 
                405                 410                 415     


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
            420                 425                 430         


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
        435                 440                 445             


Lys Gly Lys Ala Thr Phe Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    450                 455                 460                 


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Arg Val Thr Asp Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr 
                485                 490                 495     


Thr Val Thr Val Ser 
            500     


<210>  2
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  cam16

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu Ala Val 
        35                  40                  45              


Ala Ser Ile Thr Trp Ser Gly Arg Asp Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Pro Trp Pro Val Ala Ala Pro Arg Ser Gly Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  3

Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
1               5                   10                  15      


Asn His Ala Tyr 
            20  


<210>  4
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  4

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  5

Glu Ala Ser Gly Gly Pro Glu 
1               5           


<210>  6
<211>  236
<212>  PRT
<213>  Artificial

<220>
<223>  anti-HER2

<400>  6

Asp Val Gln Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Thr Pro Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Gly 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Ser Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser 
            100                 105                 110         


Gly Lys Ser Ser Glu Gly Lys Gly Val Gln Leu Gln Glu Ser Gly Pro 
        115                 120                 125             


Glu Val Val Lys Pro Gly Gly Ser Met Lys Ile Ser Cys Lys Thr Ser 
    130                 135                 140                 


Gly Tyr Ser Phe Thr Gly His Thr Met Asn Trp Val Lys Gln Ser His 
145                 150                 155                 160 


Gly Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Asp 
                165                 170                 175     


Thr Asn Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Phe Thr Val Asp 
            180                 185                 190         


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu 
        195                 200                 205             


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Val Thr Asp Trp Tyr Phe 
    210                 215                 220                 


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
225                 230                 235     


<210>  7
<211>  1517
<212>  DNA
<213>  Artificial

<220>
<223>  cam1615HER2 DNA sequence

<400>  7
ccatggagca ggtgcagctg gtggagtctg ggggaggctt ggtgcagcct gggggctctc       60

tgagactctc ctgtgcagcc tctggcctca ccttcagtag ctataacatg ggctggttcc      120

gccaggctcc agggcaaggc cttgaggctg tagcatctat tacctggagt ggtcgggaca      180

cattctatgc agactccgtg aagggccgat tcaccatctc cagagacaac tccaagaaca      240

ctctctatct gcaaatgaac agcctgcgcg cggaggacac ggccgtttat tattgtgctg      300

caaacccctg gccagtggcg gcgccacgta gtggcaccta ctggggccaa gggaccctgg      360

tcaccgtctc ctcaccgtct ggtcaggctg gtgctgctgc tagcgaatct ctgttcgttt      420

ctaaccacgc ttacaactgg gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta      480

ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac cccagttgca      540

aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt gagtccggag      600

atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac agtttgtctt      660

ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag gaaaaaaata      720

ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac acttctgaag      780

cttccggagg tcccgaggac gtccagctga cccagtctcc agcaatcctg tctgcatctc      840

caggggagaa ggtcacaatg acttgcaggg ccaccccaag tgtaagttac atgcactggt      900

atcagcagaa gccaggatcc tcccccaaac cttggattta taccacatcc aacctggctt      960

ctggagtccc tgctcgcttc agtggcggtg ggtctgggac ctcttactct ctcacagtca     1020

gcagagtgga ggctgaagat gctgccactt attactgcca gcagtggagt cgtagcccac     1080

ccacgttcgg aggggggtcc aagctggaaa taaaaggttc tacctctggt tctggtaaat     1140

cttctgaagg taaaggtgtg cagctgcagg agtcaggacc tgaggtggtg aagcctggag     1200

gttcaatgaa gatatcctgc aagacttctg gttactcatt cactggccac accatgaact     1260

gggtgaagca gagccatgga aagaaccttg agtggattgg acttattaat ccttacaatg     1320

gtgatactaa ctacaaccag aagttcaagg gcaaggccac atttactgta gacaagtcgt     1380

ccagcacagc ctacatggag ctcctcagtc tgacatctga ggactctgca gtctattact     1440

gtgcaaggag ggttacggac tggtacttcg atgtctgggg cgcagggacc acggtcaccg     1500

tctcctaata gctcgag                                                    1517


<210>  8
<211>  8
<212>  DNA
<213>  Artificial

<220>
<223>  NcoI restriction site and start codon

<400>  8
ccatggag                                                                 8


<210>  9
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  cam16

<400>  9
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctgggggctc tctgagactc       60

tcctgtgcag cctctggcct caccttcagt agctataaca tgggctggtt ccgccaggct      120

ccagggcaag gccttgaggc tgtagcatct attacctgga gtggtcggga cacattctat      180

gcagactccg tgaagggccg attcaccatc tccagagaca actccaagaa cactctctat      240

ctgcaaatga acagcctgcg cgcggaggac acggccgttt attattgtgc tgcaaacccc      300

tggccagtgg cggcgccacg tagtggcacc tactggggcc aagggaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  10
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  linker

<400>  10
ccgtctggtc aggctggtgc tgctgctagc gaatctctgt tcgtttctaa ccacgcttac       60


<210>  11
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  11
aactgggtga atgtaataag tgatttgaaa aaaattgaag atcttattca atctatgcat       60

attgatgcta ctttatatac ggaaagtgat gttcacccca gttgcaaagt aacagcaatg      120

aagtgctttc tcttggagtt acaagttatt tcacttgagt ccggagatgc aagtattcat      180

gatacagtag aaaatctgat catcctagca aacaacagtt tgtcttctaa tgggaatgta      240

acagaatctg gatgcaaaga atgtgaggaa ctggaggaaa aaaatattaa agaatttttg      300

cagagttttg tacatattgt ccaaatgttc atcaacactt ct                         342


<210>  12
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  linker

<400>  12
gaagcttccg gaggtcccga g                                                 21


<210>  13
<211>  708
<212>  DNA
<213>  Artificial

<220>
<223>  anti-HER2

<400>  13
gacgtccagc tgacccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacttgca gggccacccc aagtgtaagt tacatgcact ggtatcagca gaagccagga      120

tcctccccca aaccttggat ttataccaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggcg gtgggtctgg gacctcttac tctctcacag tcagcagagt ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtcgtagcc cacccacgtt cggagggggg      300

tccaagctgg aaataaaagg ttctacctct ggttctggta aatcttctga aggtaaaggt      360

gtgcagctgc aggagtcagg acctgaggtg gtgaagcctg gaggttcaat gaagatatcc      420

tgcaagactt ctggttactc attcactggc cacaccatga actgggtgaa gcagagccat      480

ggaaagaacc ttgagtggat tggacttatt aatccttaca atggtgatac taactacaac      540

cagaagttca agggcaaggc cacatttact gtagacaagt cgtccagcac agcctacatg      600

gagctcctca gtctgacatc tgaggactct gcagtctatt actgtgcaag gagggttacg      660

gactggtact tcgatgtctg gggcgcaggg accacggtca ccgtctcc                   708


<210>  14
<211>  13
<212>  DNA
<213>  Artificial

<220>
<223>  two stop codons and XhoI restriction site

<400>  14
taatagctcg aga                                                          13


<210>  15
<211>  236
<212>  PRT
<213>  Artificial

<220>
<223>  e23

<400>  15

Asp Val Gln Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Thr Pro Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Gly 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Ser Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Ser Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser 
            100                 105                 110         


Gly Lys Ser Ser Glu Gly Lys Gly Val Gln Leu Gln Glu Ser Gly Pro 
        115                 120                 125             


Glu Val Val Lys Pro Gly Gly Ser Met Lys Ile Ser Cys Lys Thr Ser 
    130                 135                 140                 


Gly Tyr Ser Phe Thr Gly His Thr Met Asn Trp Val Lys Gln Ser His 
145                 150                 155                 160 


Gly Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Asp 
                165                 170                 175     


Thr Asn Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Phe Thr Val Asp 
            180                 185                 190         


Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu 
        195                 200                 205             


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Val Thr Asp Trp Tyr Phe 
    210                 215                 220                 


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
225                 230                 235     


<210>  16
<211>  248
<212>  PRT
<213>  Artificial

<220>
<223>  trastuzumab-based scFv

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys 
        115                 120                 125             


Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
            180                 185                 190         


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys Arg Thr Val 
                245             


<210>  17
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  anti-HER2 light chain

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  18
<211>  225
<212>  PRT
<213>  Artificial

<220>
<223>  anti-HER2 heavy chain

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys 
225 


<210>  19
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  lumretuzumab heavy chain

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Ala Gly Thr Gly Ser Pro Ser Tyr Asn Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Arg Asp Tyr Tyr Ser Asn Ser Leu Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  20
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  lumretuzumab light chain

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Ser 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  21
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  seribantumab heavy chain

<400>  21

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Trp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Leu Lys Met Ala Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  22
<211>  217
<212>  PRT
<213>  Artificial

<220>
<223>  seribantumab light chain

<400>  22

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Val Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Ile Phe Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
145                 150                 155                 160 


Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Ala Glu Cys Ser 
    210                 215         


<210>  23
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  KTN3379 light chain

<400>  23

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Leu Ser Asn Ile Gly Leu Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro 
                85                  90                  95      


Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  24
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  patritumab subunit 1

<400>  24

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Glu Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Trp Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  25
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  patritumab subunit 2

<400>  25

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Glu Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Trp Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  26
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  patritumab subunit 3

<400>  26

Asp Ile Glu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Ser Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Asn Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  27
<211>  220
<212>  PRT
<213>  Artificial

<220>
<223>  patritumab subunit 4

<400>  27

Asp Ile Glu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Ser Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Asn Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  28
<211>  524
<212>  PRT
<213>  Artificial

<220>
<223>  trastuzumab-based TriKE

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu Ala Val 
        35                  40                  45              


Ala Ser Ile Thr Trp Ser Gly Arg Asp Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Pro Trp Pro Val Ala Ala Pro Arg Ser Gly Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
145                 150                 155                 160 


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
                165                 170                 175     


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
            180                 185                 190         


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
        195                 200                 205             


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
    210                 215                 220                 


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
225                 230                 235                 240 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
                245                 250                 255     


Thr Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
            260                 265                 270         


Ser Thr Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        275                 280                 285             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
    290                 295                 300                 


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
305                 310                 315                 320 


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
                325                 330                 335     


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
            340                 345                 350         


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        355                 360                 365             


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
    370                 375                 380                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser 
385                 390                 395                 400 


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser 
    450                 455                 460                 


Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg 
465                 470                 475                 480 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
                485                 490                 495     


Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe 
            500                 505                 510         


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
        515                 520                 


<210>  29
<211>  1572
<212>  DNA
<213>  Artificial

<220>
<223>  trastuzumab-based TriKE, H. sapiens codon optimized

<400>  29
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctgggggctc tctgagactc       60

tcctgtgcag cctctggcct caccttcagt agctataaca tgggctggtt ccgccaggct      120

ccagggcaag gccttgaggc tgtagcatct attacctgga gtggtcggga cacattctat      180

gcagactccg tgaagggccg attcaccatc tccagagaca actccaagaa cactctctat      240

ctgcaaatga acagcctgcg cgcggaggac acggccgttt attattgtgc tgcaaacccc      300

tggccagtgg cggcgccacg tagtggcacc tactggggcc aagggaccct ggtcaccgtc      360

tcctcatctg gcggcggcgg ttctggtgga ggaggtagtg gggggggagg aagcggaggg      420

ggtggctcag ggaactgggt gaatgtaata agtgatttga aaaaaattga agatcttatt      480

caatctatgc atattgatgc tactttatat acggaaagtg atgttcaccc cagttgcaaa      540

gtaacagcaa tgaagtgctt tctcttggag ttacaagtta tttcacttga gtccggagat      600

gcaagtattc atgatacagt agaaaatctg atcatcctag caaacaacag tttgtcttct      660

aatgggaatg taacagaatc tggatgcaaa gaatgtgagg aactggagga aaaaaatatt      720

aaagaatttt tgcagagttt tgtacatatt gtccaaatgt tcatcaacac ttctggcagt      780

accagcgggt cagggaaacc tggcagtggg gaaggttcca caaaaggtga ggttcagctc      840

gtggaatccg gcggcgggct ggtccaacca ggtgggagtc tccgcctgtc atgtgccgca      900

agcggattca atataaaaga tacatatata cattgggtaa gacaggcccc cggtaagggt      960

ctggagtggg ttgccagaat ttatcccact aatggataca ctcgttacgc cgattctgtg     1020

aaaggccggt ttaccatctc tgctgacacc tcaaagaaca ccgcgtacct ccagatgaac     1080

tccctgaggg cagaggacac ggctgtctat tattgctctc gctggggcgg cgacgggttt     1140

tatgccatgg attactgggg tcaggggacc ctagttacag tgagcagcgg tagtacttct     1200

gggagcggca agcctggctc cggagaagga tccaccaaag gggatatcca gatgacgcag     1260

agcccatcat cattgagtgc cagtgtgggc gaccgggtca cgatcacctg tagggcatct     1320

caggacgtaa acacagcggt ggcatggtac cagcaaaaac ctggaaaggc cccaaaactt     1380

ttgatctaca gcgctagctt cttatactcc ggcgtcccct cacgattctc cggctccaga     1440

agtggaacag actttactct gacaatttct tcgcttcagc ccgaggattt tgctacctat     1500

tattgccagc aacactacac aacccctccg actttcggac aagggacaaa ggtggaaatt     1560

aagaggactg tg                                                         1572


<210>  30
<211>  1572
<212>  DNA
<213>  Artificial

<220>
<223>  trastuzumab-based TriKE, E. coli codon optimized

<400>  30
caggtgcagc tggtggagtc tggtggcggc ttggtgcagc ctggtggctc tctgcgcctg       60

tcctgtgcgg cctctggcct caccttcagc agctataaca tgggctggtt ccgccaggct      120

ccaggacaag gccttgaggc tgtggcgtct attacctgga gtggtcggga caccttctat      180

gcggactccg tgaaaggccg tttcaccatc tcgcgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg cgcggaggac acggccgttt attattgtgc ggcaaacccc      300

tggccggttg cggcgccgcg tagtggcacc tactggggcc aagggaccct ggtcaccgtc      360

tcctcatctg gcggcggcgg tagcggtggc ggaggtagcg gggggggtgg aagcggtggt      420

ggtggctcag ggaactgggt gaatgtaata agtgatttga aaaaaattga agatctgatt      480

cagagcatgc atattgatgc gacgttatat acggaatcgg atgttcaccc aagttgcaaa      540

gttacagcaa tgaaatgctt tttgttagag ttacaagtta tttcacttga gtcgggagat      600

gcaagtattc atgatactgt agaaaatctg atcatcctgg caaacaacag cttgtcgtcg      660

aatgggaatg taacagaatc tggatgcaaa gaatgtgaag aactggaaga aaaaaatatt      720

aaagaatttt tgcagagttt tgttcacatt gtccaaatgt tcatcaacac ttctggcagt      780

accagcggtt caggtaaacc gggcagcggg gaaggttcca caaaaggtga agttcagctc      840

gtggaaagcg gcggcggtct ggtccagcca ggtgggagtc tccgcctgtc atgtgccgcg      900

agcggtttta atatcaaaga tacatatata cattgggtaa gacaggcccc gggtaagggt      960

ctggagtggg ttgcgcgtat ttatccgacg aatggataca ctcgttacgc cgattctgtg     1020

aaaggccgct ttaccatctc agccgacacc tcaaagaaca ccgcgtactt acagatgaac     1080

tccctgcgcg cagaagacac ggctgtctat tattgctcgc gctggggcgg cgacggtttt     1140

tatgccatgg attactgggg tcaggggacc ctagttactg tgagcagcgg tagtacttct     1200

gggagcggca aacctggctc cggagaaggt tcgaccaaag gggatatcca gatgacgcag     1260

agcccgtcat cactgtcggc cagtgtgggc gatcgggtca cgatcacctg ccgtgcatcg     1320

caggatgtaa atacagcggt ggcatggtac cagcaaaaac ctggaaaggc cccaaaactt     1380

ctgatctaca gcgctagctt cttatactcc ggcgtcccgt cacgattttc cggctcccgt     1440

agtggaacgg actttactct gacaatttct tcgcttcagc ccgaggattt tgctacctat     1500

tattgccagc aacactacac caccccgccg actttcggcc aagggacgaa agtggaaatt     1560

aagaggacgg tg                                                         1572


<210>  31
<211>  497
<212>  PRT
<213>  Artificial

<220>
<223>  partial trastuzumab-based TriKE

<400>  31

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
        35                  40                  45              


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
            100                 105                 110         


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
                245                 250                 255     


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
            260                 265                 270         


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
        275                 280                 285             


Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp 
    290                 295                 300                 


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn 
305                 310                 315                 320 


Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
                325                 330                 335     


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
            340                 345                 350         


Phe Ile Asn Thr Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
        355                 360                 365             


Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Leu Thr Phe Ser Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro 
                405                 410                 415     


Gly Gln Gly Leu Glu Ala Val Ala Ser Ile Thr Trp Ser Gly Arg Asp 
            420                 425                 430         


Thr Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        435                 440                 445             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    450                 455                 460                 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asn Pro Trp Pro Val Ala Ala 
465                 470                 475                 480 


Pro Arg Ser Gly Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                485                 490                 495     


Ser 
    


<210>  32
<211>  244
<212>  PRT
<213>  Artificial

<220>
<223>  partial trastuzumab-based TriKE

<400>  32

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys 
                


<210>  33
<211>  759
<212>  PRT
<213>  Artificial

<220>
<223>  trastuzumab-based TriKE

<400>  33

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
                245                 250                 255     


Glu Glu Asn Pro Gly Pro Met Gly Trp Ser Cys Ile Ile Leu Phe Leu 
            260                 265                 270         


Val Ala Thr Ala Thr Gly Val His Ser Asp Ile Gln Met Thr Gln Ser 
        275                 280                 285             


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
    290                 295                 300                 


Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys 
305                 310                 315                 320 


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
                325                 330                 335     


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe 
            340                 345                 350         


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
        355                 360                 365             


Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
    370                 375                 380                 


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
385                 390                 395                 400 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                405                 410                 415     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            420                 425                 430         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        435                 440                 445             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    450                 455                 460                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
465                 470                 475                 480 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly 
                485                 490                 495     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Val Asn Val Ile Ser 
            500                 505                 510         


Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala 
        515                 520                 525             


Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala 
    530                 535                 540                 


Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly 
545                 550                 555                 560 


Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn 
                565                 570                 575     


Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu 
            580                 585                 590         


Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
        595                 600                 605             


Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Ser Thr Ser Gly 
    610                 615                 620                 


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln 
625                 630                 635                 640 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                645                 650                 655     


Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr Asn Met Gly 
            660                 665                 670         


Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu Ala Val Ala Ser Ile 
        675                 680                 685             


Thr Trp Ser Gly Arg Asp Thr Phe Tyr Ala Asp Ser Val Lys Gly Arg 
    690                 695                 700                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
705                 710                 715                 720 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asn 
                725                 730                 735     


Pro Trp Pro Val Ala Ala Pro Arg Ser Gly Thr Tyr Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Ser Ser 
        755                 


<210>  34
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  34

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly 
            20          


<210>  35
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  35

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  36
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  signal peptide

<400>  36

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  37
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  T2A self-cleaving peptide

<400>  37

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


