                         SEQUENCE LISTING

<110>  Syngenta Crop Protection AG
       Syngenta Biotechnology China Co. Ltd.
       LI, Jiang
       XU, Jianping
 
<120>  METHODS AND COMPOSITIONS FOR DNA BASE EDITING

<130>  81945-WO-REG-ORG-P-1

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  229
<212>  PRT
<213>  Rattus norvegicus

<400>  1

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  2
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  atgtccagcgagaccggccccgtggcggtggaccccaccctgcgcaggcgcatcgagccgcacga
       gttcgaggtgttcttcgaccccagggagctccgcaaggagacctgcctcctgtacgagatcaact
       ggggcggcaggcactccatctggaggcacacgagccagaacaccaacaagcacgtcgaggtgaac
       ttcatcgagaagttcaccacggagaggtacttctgcccgaacacgcgctgctccatcacgtggtt

<400>  2
atgtccagcg agaccggccc cgtggcggtg gaccccaccc tgcgcaggcg catcgagccg       60

cacgagttcg aggtgttctt cgaccccagg gagctccgca aggagacctg cctcctgtac      120

gagatcaact ggggcggcag gcactccatc tggaggcaca cgagccagaa caccaacaag      180

cacgtcgagg tgaacttcat cgagaagttc accacggaga ggtacttctg cccgaacacg      240

cgctgctcca tcacgtggtt cctctcgtgg agcccatgcg gcgagtgctc cagggcgatc      300

acggagttcc tcagccgcta cccgcacgtg accctgttca tctacatcgc taggctctac      360

caccacgcgg accccaggaa caggcagggc ctcagggacc tgatctccag cggcgtcacg      420

atccagatca tgaccgagca ggagtccggc tactgctgga ggaacttcgt gaactactcc      480

ccgagcaacg aggcccactg gccccgctac ccgcacctct gggtccgcct ctacgtgctc      540

gagctgtact gcatcatcct cggcctgccg ccctgcctca acatcctgag gcgcaagcag      600

ccccagctga cgttcttcac catcgccctg cagagctgcc actaccagag gctcccgccc      660

cacatcctgt gggcgaccgg gctcaag                                          687


<210>  3
<211>  1251
<212>  PRT
<213>  Moraxella bovis

<400>  3

Met Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val 
1               5                   10                  15      


Arg Phe Glu Leu Lys Pro Ile Gly Arg Thr Leu Glu His Ile His Ala 
            20                  25                  30          


Lys Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp Met Tyr Gln Lys 
        35                  40                  45              


Val Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met 
    50                  55                  60                  


Met Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr 
65                  70                  75                  80  


Leu Lys Phe Arg Lys Asn Pro Lys Asp Asp Gly Leu Gln Lys Gln Leu 
                85                  90                  95      


Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ser Val Lys Pro Ile Gly 
            100                 105                 110         


Ser Gly Gly Lys Tyr Lys Thr Gly Tyr Asp Arg Leu Phe Gly Ala Lys 
        115                 120                 125             


Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile 
    130                 135                 140                 


Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His Leu Ala His Phe 
145                 150                 155                 160 


Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn 
                165                 170                 175     


Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile 
            180                 185                 190         


His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr 
        195                 200                 205             


Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu 
    210                 215                 220                 


Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr 
225                 230                 235                 240 


His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr Asn Arg Ile Ile 
                245                 250                 255     


Gly Glu Val Asn Gly Tyr Thr Asn Lys His Asn Gln Ile Cys His Lys 
            260                 265                 270         


Ser Glu Arg Ile Ala Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser 
        275                 280                 285             


Asp Gly Met Gly Val Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser 
    290                 295                 300                 


Glu Met Cys Gln Ala Val Asn Glu Phe Tyr Arg His Tyr Thr Asp Val 
305                 310                 315                 320 


Phe Ala Lys Val Gln Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys 
                325                 330                 335     


Asp Gly Ile Tyr Val Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln 
            340                 345                 350         


Ala Phe Gly Asp Phe Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr 
        355                 360                 365             


Val Asp Val Val Asn Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys 
    370                 375                 380                 


Thr Asp Asn Ala Lys Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile 
385                 390                 395                 400 


Lys Gly Val His Ser Leu Ala Ser Leu Glu Gln Ala Ile Glu His His 
                405                 410                 415     


Thr Ala Arg His Asp Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln 
            420                 425                 430         


Tyr Phe Lys His Gly Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile 
        435                 440                 445             


His Asn Asn His Ser Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro 
    450                 455                 460                 


Ala Gly Glu Arg Ala Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu 
465                 470                 475                 480 


Met Thr Gln Leu Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn 
                485                 490                 495     


Val Ala His Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn 
            500                 505                 510         


Gln Asp Gly Asn Phe Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu 
        515                 520                 525             


Ala Lys Ile Pro Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln 
    530                 535                 540                 


Lys Pro Phe Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr 
545                 550                 555                 560 


Leu Leu Asn Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val 
                565                 570                 575     


Ile Leu Gln Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala 
            580                 585                 590         


His Lys Lys Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Asn Val Tyr 
        595                 600                 605             


Gln Lys Met Val Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro 
    610                 615                 620                 


Lys Val Phe Phe Ala Lys Ser Asn Leu Asp Tyr Tyr Asn Pro Ser Ala 
625                 630                 635                 640 


Glu Leu Leu Asp Lys Tyr Ala Lys Gly Thr His Lys Lys Gly Asp Asn 
                645                 650                 655     


Phe Asn Leu Lys Asp Cys His Ala Leu Ile Asp Phe Phe Lys Ala Gly 
            660                 665                 670         


Ile Asn Lys His Pro Glu Trp Gln His Phe Gly Phe Lys Phe Ser Pro 
        675                 680                 685             


Thr Ser Ser Tyr Arg Asp Leu Ser Asp Phe Tyr Arg Glu Val Glu Pro 
    690                 695                 700                 


Gln Gly Tyr Gln Val Lys Phe Val Asp Ile Asn Ala Asp Tyr Ile Asp 
705                 710                 715                 720 


Glu Leu Val Glu Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
                725                 730                 735     


Asp Phe Ser Pro Lys Ala His Gly Lys Pro Asn Leu His Thr Leu Tyr 
            740                 745                 750         


Phe Lys Ala Leu Phe Ser Glu Asp Asn Leu Ala Asp Pro Ile Tyr Lys 
        755                 760                 765             


Leu Asn Gly Glu Ala Gln Ile Phe Tyr Arg Lys Ala Ser Leu Asp Met 
    770                 775                 780                 


Asn Glu Thr Thr Ile His Arg Ala Gly Glu Val Leu Glu Asn Lys Asn 
785                 790                 795                 800 


Pro Asp Asn Pro Lys Lys Arg Gln Phe Val Tyr Asp Ile Ile Lys Asp 
                805                 810                 815     


Lys Arg Tyr Thr Gln Asp Lys Phe Met Leu His Val Pro Ile Thr Met 
            820                 825                 830         


Asn Phe Gly Val Gln Gly Met Thr Ile Lys Glu Phe Asn Lys Lys Val 
        835                 840                 845             


Asn Gln Ser Ile Gln Gln Tyr Asp Glu Val Asn Val Ile Gly Ile Asp 
    850                 855                 860                 


Arg Gly Glu Arg His Leu Leu Tyr Leu Thr Val Ile Asn Ser Lys Gly 
865                 870                 875                 880 


Glu Ile Leu Glu Gln Arg Ser Leu Asn Asp Ile Thr Thr Ala Ser Ala 
                885                 890                 895     


Asn Gly Thr Gln Val Thr Thr Pro Tyr His Lys Ile Leu Asp Lys Arg 
            900                 905                 910         


Glu Ile Glu Arg Leu Asn Ala Arg Val Gly Trp Gly Glu Ile Glu Thr 
        915                 920                 925             


Ile Lys Glu Leu Lys Ser Gly Tyr Leu Ser His Val Val His Gln Ile 
    930                 935                 940                 


Asn Gln Leu Met Leu Lys Tyr Asn Ala Ile Val Val Leu Glu Asp Leu 
945                 950                 955                 960 


Asn Phe Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln Ile Tyr 
                965                 970                 975     


Gln Asn Phe Glu Asn Ala Leu Ile Lys Lys Leu Asn His Leu Val Leu 
            980                 985                 990         


Lys Asp Lys Ala Asp Asp Glu Ile  Gly Ser Tyr Lys Asn  Ala Leu Gln 
        995                 1000                 1005             


Leu Thr  Asn Asn Phe Thr Asp  Leu Lys Ser Ile Gly  Lys Gln Thr 
    1010                 1015                 1020             


Gly Phe  Leu Phe Tyr Val Pro  Ala Trp Asn Thr Ser  Lys Ile Asp 
    1025                 1030                 1035             


Pro Glu  Thr Gly Phe Val Asp  Leu Leu Lys Pro Arg  Tyr Glu Asn 
    1040                 1045                 1050             


Ile Ala  Gln Ser Gln Ala Phe  Phe Gly Lys Phe Asp  Lys Ile Cys 
    1055                 1060                 1065             


Tyr Asn  Thr Asp Lys Gly Tyr  Phe Glu Phe His Ile  Asp Tyr Ala 
    1070                 1075                 1080             


Lys Phe  Thr Asp Lys Ala Lys  Asn Ser Arg Gln Lys  Trp Ala Ile 
    1085                 1090                 1095             


Cys Ser  His Gly Asp Lys Arg  Tyr Val Tyr Asp Lys  Thr Ala Asn 
    1100                 1105                 1110             


Gln Asn  Lys Gly Ala Ala Lys  Gly Ile Asn Val Asn  Asp Glu Leu 
    1115                 1120                 1125             


Lys Ser  Leu Phe Ala Arg Tyr  His Ile Asn Asp Lys  Gln Pro Asn 
    1130                 1135                 1140             


Leu Val  Met Asp Ile Cys Gln  Asn Asn Asp Lys Glu  Phe His Lys 
    1145                 1150                 1155             


Ser Leu  Met Cys Leu Leu Lys  Thr Leu Leu Ala Leu  Arg Tyr Ser 
    1160                 1165                 1170             


Asn Ala  Ser Ser Asp Glu Asp  Phe Ile Leu Ser Pro  Val Ala Asn 
    1175                 1180                 1185             


Asp Glu  Gly Val Phe Phe Asn  Ser Ala Leu Ala Asp  Asp Thr Gln 
    1190                 1195                 1200             


Pro Gln  Asn Ala Asp Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys 
    1205                 1210                 1215             


Gly Leu  Trp Leu Leu Asn Glu  Leu Lys Asn Ser Asp  Asp Leu Asn 
    1220                 1225                 1230             


Lys Val  Lys Leu Ala Ile Asp  Asn Gln Thr Trp Leu  Asn Phe Ala 
    1235                 1240                 1245             


Gln Asn  Arg 
    1250     


<210>  4
<211>  3753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized

<400>  4
gctctgtttc aagattttac acatctgtac ccgctgagta aaacagtgcg gttcgagctg       60

aaacccatag gaaggaccct cgagcacatc cacgcgaaga attttctgag ccaggatgaa      120

actatggctg atatgtatca aaaagttaag gtcattttgg acgactatca tcgcgatttt      180

attgccgaca tgatgggaga ggtgaaactc acgaagcttg ctgaatttta cgacgtctat      240

ctgaagttca ggaaaaatcc taaggacgat gggctgcaaa aacagcttaa agaccttcaa      300

gctgtccttc ggaaggaatc ggtgaagcct atagggtcag gtgggaagta caaaacaggc      360

tacgatagac tctttggggc aaaactcttc aaagatggaa aagagttggg tgacctcgca      420

aaattcgtta tagcccaaga aggtgagtct tctccgaagc tggctcatct tgctcatttt      480

gagaagttca gcacgtattt tactggattt cacgataatc ggaagaatat gtactcggat      540

gaagacaagc atactgcaat agcgtacagg ctcatccatg agaatttgcc gagattcatc      600

gacaatctgc aaatcttgac aacaatcaaa caaaagcata gcgccctcta tgatcagata      660

atcaacgagc tcacggcctc cgggctcgac gtctccttgg cttctcatct tgacgggtat      720

cacaagctcc ttacacaaga ggggatcacg gcatacaaca ggatcatagg agaggtgaat      780

ggatatacaa ataagcataa ccagatatgc cacaagagcg agcgcatagc gaaacttaga      840

cccttgcaca agcaaatcct ttctgacgga atgggagtgt cattccttcc gtctaagttc      900

gcggatgata gtgagatgtg ccaagcggtc aacgaatttt atcgccatta tactgacgtg      960

ttcgcaaagg tgcaaagtct ctttgacgga tttgatgatc accagaaaga cgggatctat     1020

gttgaacaca aaaaccttaa tgaactgagc aaacaggcgt tcggcgactt tgctttgctg     1080

gggagggtcc ttgatggata ctacgtggac gttgtcaatc cggagttcaa tgagcggttc     1140

gcaaaggcca agactgacaa tgcgaaagcc aagcttacaa aagaaaagga caaattcatt     1200

aaaggagtcc actcactggc ttccctcgaa caagcaatag aacaccatac agctagacac     1260

gacgatgaga gtgttcaagc cggaaaactt ggccagtact tcaaacacgg tttggcgggg     1320

gttgacaacc cgattcagaa aattcacaat aaccattcga cgattaaagg gtttctggaa     1380

agggaaaggc ctgctgggga acgggcgctc ccgaagatca agtcaggaaa aaacccagaa     1440

atgacacagc tcaggcagct gaaggaactt ttggacaacg cattgaatgt ggcgcacttc     1500

gctaagctgc tgacaactaa aacaaccttg gacaaccagg atggaaattt ttacggggag     1560

tttggggtgc tttacgacga gctggctaaa attccaactc tctacaataa ggttagagat     1620

tatctctctc aaaagccctt ttctaccgaa aagtataagc tcaacttcgg caatccgacc     1680

cttctcaatg ggtgggacct gaacaaagag aaagataact ttggggttat acttcagaag     1740

gatggatgct attacttggc gcttcttgat aaggctcata aaaaagtttt cgacaacgcc     1800

cctaacactg gtaagaacgt ctaccaaaag atggtctaca aactgttgcc cggccccaac     1860

aaaatgcttc ctaaagtgtt tttcgcaaaa tcgaatctcg actattataa tccatctgcc     1920

gagctccttg acaaatatgc taaggggacc cataaaaagg gtgataattt caacctgaag     1980

gactgccacg cgcttatcga ctttttcaaa gccgggataa ataagcatcc ggagtggcaa     2040

cattttggtt ttaaattttc gccaacgtcg tcctatcgcg acctttccga tttctatagg     2100

gaagttgaac ctcaggggta ccaggtcaaa tttgttgaca ttaatgcgga ctacattgat     2160

gaattggtgg agcaagggaa gctctacctc tttcaaatat ataacaaaga tttctcgcca     2220

aaagcgcatg gtaaaccgaa tcttcatacc ttgtacttta aagcactttt ttcagaagat     2280

aacttggcgg acccgatcta caagctgaat ggggaagctc agatcttcta caggaaagct     2340

tcgttggaca tgaacgagac taccatacat cgcgcgggag aggtgcttga gaacaaaaat     2400

cccgacaacc cgaaaaagcg gcaattcgtt tacgacatca tcaaagacaa acggtacacg     2460

caggacaaat ttatgctcca cgtccccatt accatgaatt ttggagtcca aggcatgacc     2520

attaaggaat tcaacaaaaa ggtcaaccaa agtattcagc aatacgatga agtcaatgtc     2580

ataggcatag atcggggaga aaggcatctg ttgtatctta ccgtgattaa ctctaagggt     2640

gaaatactgg agcaacggtc acttaacgat ataaccacgg cgtccgcgaa cggtacacaa     2700

gtgaccactc cctaccacaa aatattggat aaaagggaga tagaacgctt gaatgcccgc     2760

gttggctggg gtgagattga gaccatcaaa gagcttaaat cgggatattt gtctcacgtc     2820

gttcatcaaa ttaaccaact catgcttaag tacaatgcaa tcgttgtgct cgaggacctg     2880

aactttggtt tcaaaagagg gaggttcaag gtggaaaaac aaatttacca gaactttgaa     2940

aacgcgctta tcaagaaatt gaatcacctt gttttgaaag ataaggcaga tgacgaaatc     3000

gggtcgtata aaaatgcact ccagttgaca aataatttca cggatttgaa gtcgatcggc     3060

aagcaaacag ggttcctctt ttatgtgcca gcgtggaata catcaaaaat tgatccggag     3120

acgggatttg tcgacttgct gaagcctagg tatgagaaca ttgcccaatc tcaggccttt     3180

ttcggcaaat tcgataaaat atgctacaac acagacaaag gttattttga atttcacatt     3240

gattacgcca aatttacaga taaggcgaaa aacagcagac agaaatgggc tatctgttct     3300

catggggaca aacgctatgt ctacgataag acggctaatc aaaataaagg cgccgcaaaa     3360

ggtattaatg tgaatgatga gctgaaaagc ttgtttgccc gctaccatat caatgataaa     3420

caaccaaact tggtgatgga catatgccag aacaatgaca aagaattcca caagtcactc     3480

atgtgcctgc ttaaaaccct tttggcgctg cggtatagca atgcatctag cgatgaagac     3540

tttattttga gtcccgtggc caacgacgag ggcgtgtttt ttaattcagc cttggcggac     3600

gatacgcagc cccagaatgc ggacgcaaac ggcgcgtacc acattgcact gaagggactg     3660

tggcttctga acgagctgaa aaatagcgac gacctgaata aagtcaagtt ggccattgac     3720

aatcaaacct ggttgaattt cgctcaaaat aga                                  3753


<210>  5
<211>  4367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized fusion protein

<400>  5
atgtccagcg agaccggccc cgtggcggtg gaccccaccc tgcgcaggcg catcgagccg       60

cacgagttcg aggtgttctt cgaccccagg gagctccgca aggagacctg cctcctgtac      120

gagatcaact ggggcggcag gcactccatc tggaggcaca cgagccagaa caccaacaag      180

cacgtcgagg tgaacttcat cgagaagttc accacggaga ggtacttctg cccgaacacg      240

cgctgctcca tcacgtggtt cctctcgtgg agcccatgcg gcgagtgctc cagggcgatc      300

acggagttcc tcagccgcta cccgcacgtg accctgttca tctacatcgc taggctctac      360

caccacgcgg accccaggaa caggcagggc ctcagggacc tgatctccag cggcgtcacg      420

atccagatca tgaccgagca ggagtccggc tactgctgga ggaacttcgt gaactactcc      480

ccgagcaacg aggcccactg gccccgctac ccgcacctct gggtccgcct ctacgtgctc      540

gagctgtact gcatcatcct cggcctgccg ccctgcctca acatcctgag gcgcaagcag      600

ccccagctga cgttcttcac catcgccctg cagagctgcc actaccagag gctcccgccc      660

cacatcctgt gggcgaccgg gctcaagggg ggcgggggct caggcggggg cgggagcggc      720

ggcgggggct ctgggggcgg cggcagcggc gggggcggca gcgggggcgg cgggtcgatg      780

agcaagctgg agaagttcac gaactgctac tccctcagca agaccctgag gttcaaggcg      840

atcccggtcg gcaagaccca ggagaacatc gacaacaagc ggctgctggt ggaggacgag      900

aagagggctg aggactacaa gggcgtgaag aagctcctgg accgctacta cctgtccttc      960

atcaacgacg tgctccacag catcaagctc aagaacctga acaactacat cagcctcttc     1020

aggaagaaga cgcgcaccga gaaggagaac aaggagctcg agaacctgga gatcaacctg     1080

aggaaggaga tcgccaaggc gttcaagggc aacgagggct acaagtccct cttcaagaag     1140

gacatcatcg agacgatcct cccggagttc ctggacgaca aggacgagat cgccctggtc     1200

aactccttca acggcttcac cacggcgttc accggcttct tcgacaaccg cgagaacatg     1260

ttcagcgagg aggccaagtc cacgagcatc gcgttcaggt gcatcaacga gaacctcacc     1320

cgctacatct ccaacatgga catcttcgag aaggtcgacg cgatcttcga caagcacgag     1380

gtgcaggaga tcaaggagaa gatcctgaac agcgactacg acgtcgagga cttcttcgag     1440

ggcgagttct tcaacttcgt cctcacgcag gagggcatcg acgtgtacaa cgccatcatc     1500

ggtggcttcg tgaccgagtc cggcgagaag atcaagggcc tgaacgagta catcaacctc     1560

tacaaccaga agaccaagca gaagctgccg aagttcaagc ccctgtacaa gcaggtgctc     1620

tccgacaggg agtccctcag cttctacggc gagggctaca cgagcgacga ggaggtcctg     1680

gaggtgttcc gcaacaccct caacaagaac agcgagatct tctccagcat caagaagctc     1740

gagaagctgt tcaagaactt cgacgagtac tccagcgccg gcatcttcgt caagaacggc     1800

ccggcgatct ccacgatcag caaggacatc ttcggcgagt ggaacgtgat ccgcgacaag     1860

tggaacgccg agtacgacga catccacctc aagaagaagg cggtggtcac cgagaagtac     1920

gaggacgaca ggcgcaagtc cttcaagaag atcggctcct tcagcctcga gcagctgcag     1980

gagtacgccg acgcggacct gagcgtggtc gagaagctca aggagatcat catccagaag     2040

gtcgacgaga tctacaaggt gtacggctcc agcgagaagc tcttcgacgc ggacttcgtc     2100

ctcgagaagt ccctgaagaa gaacgacgcc gtggtcgcga tcatgaagga cctcctggac     2160

tccgtgaaga gcttcgagaa ttacatcaag gccttcttcg gcgagggcaa ggagacgaac     2220

agggacgagt ccttctacgg cgacttcgtc ctggcctacg acatcctcct gaaggtggac     2280

cacatctacg acgcgatccg caactacgtg acccagaagc cgtacagcaa ggacaagttc     2340

aagctctact tccagaaccc ccagttcatg ggcggctggg acaaggacaa ggagacggac     2400

tacagggcga ccatcctgcg ctacggcagc aagtactacc tcgccatcat ggacaagaag     2460

tacgcgaagt gcctgcagaa gatcgacaag gacgacgtca acggcaacta cgagaagatc     2520

aactacaagc tcctgccggg ccccaacaag atgctcccga aggtgttctt ctccaagaag     2580

tggatggcct actacaaccc cagcgaggac atccagaaga tctacaagaa cggcacgttc     2640

aagaagggcg acatgttcaa cctgaacgac tgccacaagc tcatcgactt cttcaaggac     2700

tccatcagcc gctacccgaa gtggtccaac gcctacgact tcaacttcag cgagaccgag     2760

aagtacaagg acatcgcggg cttctaccgc gaggtcgagg agcagggcta caaggtgtcc     2820

ttcgagtccg ccagcaagaa ggaggtcgac aagctggtgg aggagggcaa gctctacatg     2880

ttccagatct acaacaagga cttctccgac aagagccacg gcacgcccaa cctgcacacc     2940

atgtacttca agctcctgtt cgacgagaac aaccacggcc agatcaggct gtccggcggc     3000

gccgagctct tcatgaggag ggcgagcctg aagaaggagg agctggtggt ccaccccgct     3060

aacagcccaa tcgcgaacaa gaacccggac aaccccaaga agaccacgac cctgtcctac     3120

gacgtgtaca aggacaagag gttcagcgag gaccagtacg agctccacat cccgatcgcg     3180

atcaacaagt gccccaagaa catcttcaag atcaacaccg aggtccgcgt gctcctgaag     3240

cacgacgaca acccctacgt gatcggcatc gctaggggcg agaggaacct cctgtacatc     3300

gtggtcgtgg acggcaaggg caacatcgtg gagcagtact ccctcaacga gatcatcaac     3360

aacttcaacg gcatcaggat caagacggac taccacagcc tcctggacaa gaaggagaag     3420

gagaggttcg aggcccgcca gaactggacc tccatcgaga acatcaagga gctgaaggcg     3480

ggctacatca gccaggtcgt gcacaagatc tgcgagctcg tcgagaagta cgacgccgtg     3540

atcgccctcg cggacctgaa ctccggcttc aagaacagcc gcgtcaaggt ggagaagcag     3600

gtctaccaga agttcgagaa gatgctcatc gacaagctga actacatggt ggacaagaag     3660

tccaacccct gcgctacggg cggcgcgctg aagggctacc agatcaccaa caagttcgag     3720

agcttcaagt ccatgagcac tcagaacggc ttcatcttct acatcccggc gtggctcacg     3780

tccaagatcg accccagcac cggcttcgtc aacctcctga agacgaagta cacctccatc     3840

gccgacagca agaagttcat ctccagcttc gaccgcatca tgtatgtgcc ggaggaggac     3900

ctgttcgagt tcgccctcga ctacaagaac ttctcccgca cggacgcgga ctacatcaag     3960

aagtggaagc tgtacagcta cggcaaccgc atccgcatct tcaggaaccc caagaagaac     4020

aacgtcttcg actgggagga ggtgtgcctg acctccgcgt acaaggagct cttcaacaag     4080

tacggcatca actaccagca gggcgacatc agggctctcc tgtgcgagca gagcgacaag     4140

gccttctact ccagcttcat ggcgctgatg tccctcatgc tgcagatgag gaactcgatc     4200

accggcagga cggacgtggc cttcctcatc tccccggtga agaacagcga cggcatcttc     4260

tacgactcca ggaactacga ggcccaggag aacgcgatcc tcccaaagaa cgcggacgcc     4320

aacggcgcct acaacatcgc caggaaggtc ctctgggcta tcggcca                   4367


<210>  6
<211>  1455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  6

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu 
            260                 265                 270         


Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu 
        275                 280                 285             


Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu 
    290                 295                 300                 


Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe 
305                 310                 315                 320 


Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr 
                325                 330                 335     


Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu 
            340                 345                 350         


Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe 
        355                 360                 365             


Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu 
    370                 375                 380                 


Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val 
385                 390                 395                 400 


Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn 
                405                 410                 415     


Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe 
            420                 425                 430         


Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile 
        435                 440                 445             


Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile 
    450                 455                 460                 


Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu 
465                 470                 475                 480 


Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr 
                485                 490                 495     


Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys 
            500                 505                 510         


Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys 
        515                 520                 525             


Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu 
    530                 535                 540                 


Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu 
545                 550                 555                 560 


Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser 
                565                 570                 575     


Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser 
            580                 585                 590         


Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys 
        595                 600                 605             


Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu 
    610                 615                 620                 


Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr 
625                 630                 635                 640 


Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu 
                645                 650                 655     


Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys 
            660                 665                 670         


Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr 
        675                 680                 685             


Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser 
    690                 695                 700                 


Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp 
705                 710                 715                 720 


Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly 
                725                 730                 735     


Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala 
            740                 745                 750         


Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn 
        755                 760                 765             


Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe 
    770                 775                 780                 


Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp 
785                 790                 795                 800 


Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile 
                805                 810                 815     


Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp 
            820                 825                 830         


Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro 
        835                 840                 845             


Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr 
    850                 855                 860                 


Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe 
865                 870                 875                 880 


Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp 
                885                 890                 895     


Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr 
            900                 905                 910         


Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe 
        915                 920                 925             


Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala 
    930                 935                 940                 


Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met 
945                 950                 955                 960 


Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro 
                965                 970                 975     


Asn Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His 
            980                 985                 990         


Gly Gln Ile Arg Leu Ser Gly Gly  Ala Glu Leu Phe Met  Arg Arg Ala 
        995                 1000                 1005             


Ser Leu  Lys Lys Glu Glu Leu  Val Val His Pro Ala  Asn Ser Pro 
    1010                 1015                 1020             


Ile Ala  Asn Lys Asn Pro Asp  Asn Pro Lys Lys Thr  Thr Thr Leu 
    1025                 1030                 1035             


Ser Tyr  Asp Val Tyr Lys Asp  Lys Arg Phe Ser Glu  Asp Gln Tyr 
    1040                 1045                 1050             


Glu Leu  His Ile Pro Ile Ala  Ile Asn Lys Cys Pro  Lys Asn Ile 
    1055                 1060                 1065             


Phe Lys  Ile Asn Thr Glu Val  Arg Val Leu Leu Lys  His Asp Asp 
    1070                 1075                 1080             


Asn Pro  Tyr Val Ile Gly Ile  Ala Arg Gly Glu Arg  Asn Leu Leu 
    1085                 1090                 1095             


Tyr Ile  Val Val Val Asp Gly  Lys Gly Asn Ile Val  Glu Gln Tyr 
    1100                 1105                 1110             


Ser Leu  Asn Glu Ile Ile Asn  Asn Phe Asn Gly Ile  Arg Ile Lys 
    1115                 1120                 1125             


Thr Asp  Tyr His Ser Leu Leu  Asp Lys Lys Glu Lys  Glu Arg Phe 
    1130                 1135                 1140             


Glu Ala  Arg Gln Asn Trp Thr  Ser Ile Glu Asn Ile  Lys Glu Leu 
    1145                 1150                 1155             


Lys Ala  Gly Tyr Ile Ser Gln  Val Val His Lys Ile  Cys Glu Leu 
    1160                 1165                 1170             


Val Glu  Lys Tyr Asp Ala Val  Ile Ala Leu Ala Asp  Leu Asn Ser 
    1175                 1180                 1185             


Gly Phe  Lys Asn Ser Arg Val  Lys Val Glu Lys Gln  Val Tyr Gln 
    1190                 1195                 1200             


Lys Phe  Glu Lys Met Leu Ile  Asp Lys Leu Asn Tyr  Met Val Asp 
    1205                 1210                 1215             


Lys Lys  Ser Asn Pro Cys Ala  Thr Gly Gly Ala Leu  Lys Gly Tyr 
    1220                 1225                 1230             


Gln Ile  Thr Asn Lys Phe Glu  Ser Phe Lys Ser Met  Ser Thr Gln 
    1235                 1240                 1245             


Asn Gly  Phe Ile Phe Tyr Ile  Pro Ala Trp Leu Thr  Ser Lys Ile 
    1250                 1255                 1260             


Asp Pro  Ser Thr Gly Phe Val  Asn Leu Leu Lys Thr  Lys Tyr Thr 
    1265                 1270                 1275             


Ser Ile  Ala Asp Ser Lys Lys  Phe Ile Ser Ser Phe  Asp Arg Ile 
    1280                 1285                 1290             


Met Tyr  Val Pro Glu Glu Asp  Leu Phe Glu Phe Ala  Leu Asp Tyr 
    1295                 1300                 1305             


Lys Asn  Phe Ser Arg Thr Asp  Ala Asp Tyr Ile Lys  Lys Trp Lys 
    1310                 1315                 1320             


Leu Tyr  Ser Tyr Gly Asn Arg  Ile Arg Ile Phe Arg  Asn Pro Lys 
    1325                 1330                 1335             


Lys Asn  Asn Val Phe Asp Trp  Glu Glu Val Cys Leu  Thr Ser Ala 
    1340                 1345                 1350             


Tyr Lys  Glu Leu Phe Asn Lys  Tyr Gly Ile Asn Tyr  Gln Gln Gly 
    1355                 1360                 1365             


Asp Ile  Arg Ala Leu Leu Cys  Glu Gln Ser Asp Lys  Ala Phe Tyr 
    1370                 1375                 1380             


Ser Ser  Phe Met Ala Leu Met  Ser Leu Met Leu Gln  Met Arg Asn 
    1385                 1390                 1395             


Ser Ile  Thr Gly Arg Thr Asp  Val Ala Phe Leu Ile  Ser Pro Val 
    1400                 1405                 1410             


Lys Asn  Ser Asp Gly Ile Phe  Tyr Asp Ser Arg Asn  Tyr Glu Ala 
    1415                 1420                 1425             


Gln Glu  Asn Ala Ile Leu Pro  Lys Asn Ala Asp Ala  Asn Gly Ala 
    1430                 1435                 1440             


Tyr Asn  Ile Ala Arg Lys Val  Leu Trp Ala Ile Gly  
    1445                 1450                 1455 


<210>  7
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized

<400>  7
acgaacctgt ccgacatcat cgagaaggag accggcaagc agctcgtgat ccaggagagc       60

atcctcatgc tgccggagga ggtcgaggag gtcatcggca acaagcccga gtccgacatc      120

ctcgtccaca cggcctacga cgagtccacc gacgagaacg tgatgctcct gacctcggac      180

gctcccgagt acaagccatg ggccctggtc atccaggaca gcaacggcga gaacaagatc      240

aagatgctc                                                              249


<210>  8
<211>  83
<212>  PRT
<213>  Bacillus subtilis phage PBSX

<400>  8

Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr Gly Lys Gln Leu Val 
1               5                   10                  15      


Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val Ile 
            20                  25                  30          


Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp Glu 
        35                  40                  45              


Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu Tyr 
    50                  55                  60                  


Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys Ile 
65                  70                  75                  80  


Lys Met Leu 
            


<210>  9
<211>  6882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized fusion

<400>  9
gaattcatta tgtggtctag gtaggttcta tatataagaa aacttgaaat gttctaaaaa       60

aaaattcaag cccatgcatg attgaagcaa acggtatagc aacggtgtta acctgatcta      120

gtgatctctt gcaatcctta acggccacct accgcaggta gcaaacggcg tccccctcct      180

cgatatctcc gcggcgacct ctggcttttt ccgcggaatt gcgcggtggg gacggattcc      240

acgagaccgc gacgcaaccg cctctcgccg ctgggcccca caccgctcgg tgccgtagcc      300

tcacgggact ctttctccct cctcccccgt tataaattgg cttcatcccc tccttgcctc      360

atccatccaa atcccagtcc ccaatcccat cccttcgtag gagaaattca tcgaagctaa      420

gcgaatcctc gcgatcctct caaggtactg cgagttttcg atccccctct cgacccctcg      480

tatgtttgtg tttgtcgtag cgtttgatta ggtatgcttt ccctgtttgt gttcgtcgta      540

gcgtttgatt aggtatgctt tccctgttcg tgttcatcgt agtgtttgat taggtcgtgt      600

gaggcgatgg cctgctcgcg tccttcgatc tgtagtcgat ttgcgggtcg tggtgtagat      660

ctgcgggctg tgatgaagtt atttggtgtg atctgctcgc ctgattctgc gggttggctc      720

gagtagatat gatggttgga ccggttggtt cgtttaccgc gctagggttg ggctgggatg      780

atgttgcatg cgccgttgcg cgtgatcccg cagcaggact tgcgtttgat tgccagatct      840

cgttacgatt atgtgatttg gtttggactt tttagatctg tagcttctgc ttatgtgcca      900

gatgcgccta ctgctcatat gcctgatgat aatcataaat ggctgtggaa ctaactagtt      960

gattgcggag tcatgtatca gctacaggtg tagggactag ctacaggtgt agggacttgc     1020

gtctaattgt ttggtccttt actcatgttg caattatgca atttagttta gattgtttgt     1080

tccactcatc taggctgtaa aagggacact gcttagattg ctgtttaatc tttttagtag     1140

attatattat attggtaact tattacccct attacatgcc atacgtgact tctgctcatg     1200

cctgatgata atcatagatc actgtggaat taattagttg attgttgaat catgtttcat     1260

gtacatacca cggcacaatt gcttagttcc ttaacaaatg caaattttac tgatccatgt     1320

atgatttgcg tggttctcta atgtgaaata ctatagctac ttgttagtaa gaatcaggtt     1380

cgtatgctta atgctgtatg tgccttctgc tcatgcctga tgataatcat atatcactgg     1440

aattaattag ttgatcgttt aatcatatat caagtacata ccatgccaca atttttagtc     1500

acttaaccca tgcagattga actggtccct gcatgttttg ctaaattgtt ctattctgat     1560

tagaccatat atcatgtatt tttttttggt aatggttctc ttattttaaa tgctatatag     1620

ttctggtact tgttagaaag atctgcttca tagtttagtt gcctatccct cgaattagga     1680

tgctgagcag ctgatcctat agctttgttt catgtatcaa ttcttttgtg ttcaacagtc     1740

agtttttgtt agattcattg taacttatgg tcgcttactc ttctggtcct caatgcttgc     1800

agggatcccc taaatagacc atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg     1860

gccccgtggc ggtggacccc accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt     1920

tcttcgaccc cagggagctc cgcaaggaga cctgcctcct gtacgagatc aactggggcg     1980

gcaggcactc catctggagg cacacgagcc agaacaccaa caagcacgtc gaggtgaact     2040

tcatcgagaa gttcaccacg gagaggtact tctgcccgaa cacgcgctgc tccatcacgt     2100

ggttcctctc gtggagccca tgcggcgagt gctccagggc gatcacggag ttcctcagcc     2160

gctacccgca cgtgaccctg ttcatctaca tcgctaggct ctaccaccac gcggacccca     2220

ggaacaggca gggcctcagg gacctgatct ccagcggcgt cacgatccag atcatgaccg     2280

agcaggagtc cggctactgc tggaggaact tcgtgaacta ctccccgagc aacgaggccc     2340

actggccccg ctacccgcac ctctgggtcc gcctctacgt gctcgagctg tactgcatca     2400

tcctcggcct gccgccctgc ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct     2460

tcaccatcgc cctgcagagc tgccactacc agaggctccc gccccacatc ctgtgggcga     2520

ccgggctcaa ggggggcggg ggctcaggcg ggggcgggag cggcggcggg ggctctgggg     2580

gcggcggcag cggcgggggc ggcagcgggg gcggcgggtc gatgagcaag ctggagaagt     2640

tcacgaactg ctactccctc agcaagaccc tgaggttcaa ggcgatcccg gtcggcaaga     2700

cccaggagaa catcgacaac aagcggctgc tggtggagga cgagaagagg gctgaggact     2760

acaagggcgt gaagaagctc ctggaccgct actacctgtc cttcatcaac gacgtgctcc     2820

acagcatcaa gctcaagaac ctgaacaact acatcagcct cttcaggaag aagacgcgca     2880

ccgagaagga gaacaaggag ctcgagaacc tggagatcaa cctgaggaag gagatcgcca     2940

aggcgttcaa gggcaacgag ggctacaagt ccctcttcaa gaaggacatc atcgagacga     3000

tcctcccgga gttcctggac gacaaggacg agatcgccct ggtcaactcc ttcaacggct     3060

tcaccacggc gttcaccggc ttcttcgaca accgcgagaa catgttcagc gaggaggcca     3120

agtccacgag catcgcgttc aggtgcatca acgagaacct cacccgctac atctccaaca     3180

tggacatctt cgagaaggtc gacgcgatct tcgacaagca cgaggtgcag gagatcaagg     3240

agaagatcct gaacagcgac tacgacgtcg aggacttctt cgagggcgag ttcttcaact     3300

tcgtcctcac gcaggagggc atcgacgtgt acaacgccat catcggtggc ttcgtgaccg     3360

agtccggcga gaagatcaag ggcctgaacg agtacatcaa cctctacaac cagaagacca     3420

agcagaagct gccgaagttc aagcccctgt acaagcaggt gctctccgac agggagtccc     3480

tcagcttcta cggcgagggc tacacgagcg acgaggaggt cctggaggtg ttccgcaaca     3540

ccctcaacaa gaacagcgag atcttctcca gcatcaagaa gctcgagaag ctgttcaaga     3600

acttcgacga gtactccagc gccggcatct tcgtcaagaa cggcccggcg atctccacga     3660

tcagcaagga catcttcggc gagtggaacg tgatccgcga caagtggaac gccgagtacg     3720

acgacatcca cctcaagaag aaggcggtgg tcaccgagaa gtacgaggac gacaggcgca     3780

agtccttcaa gaagatcggc tccttcagcc tcgagcagct gcaggagtac gccgacgcgg     3840

acctgagcgt ggtcgagaag ctcaaggaga tcatcatcca gaaggtcgac gagatctaca     3900

aggtgtacgg ctccagcgag aagctcttcg acgcggactt cgtcctcgag aagtccctga     3960

agaagaacga cgccgtggtc gcgatcatga aggacctcct ggactccgtg aagagcttcg     4020

agaattacat caaggccttc ttcggcgagg gcaaggagac gaacagggac gagtccttct     4080

acggcgactt cgtcctggcc tacgacatcc tcctgaaggt ggaccacatc tacgacgcga     4140

tccgcaacta cgtgacccag aagccgtaca gcaaggacaa gttcaagctc tacttccaga     4200

acccccagtt catgggcggc tgggacaagg acaaggagac ggactacagg gcgaccatcc     4260

tgcgctacgg cagcaagtac tacctcgcca tcatggacaa gaagtacgcg aagtgcctgc     4320

agaagatcga caaggacgac gtcaacggca actacgagaa gatcaactac aagctcctgc     4380

cgggccccaa caagatgctc ccgaaggtgt tcttctccaa gaagtggatg gcctactaca     4440

accccagcga ggacatccag aagatctaca agaacggcac gttcaagaag ggcgacatgt     4500

tcaacctgaa cgactgccac aagctcatcg acttcttcaa ggactccatc agccgctacc     4560

cgaagtggtc caacgcctac gacttcaact tcagcgagac cgagaagtac aaggacatcg     4620

cgggcttcta ccgcgaggtc gaggagcagg gctacaaggt gtccttcgag tccgccagca     4680

agaaggaggt cgacaagctg gtggaggagg gcaagctcta catgttccag atctacaaca     4740

aggacttctc cgacaagagc cacggcacgc ccaacctgca caccatgtac ttcaagctcc     4800

tgttcgacga gaacaaccac ggccagatca ggctgtccgg cggcgccgag ctcttcatga     4860

ggagggcgag cctgaagaag gaggagctgg tggtccaccc cgctaacagc ccaatcgcga     4920

acaagaaccc ggacaacccc aagaagacca cgaccctgtc ctacgacgtg tacaaggaca     4980

agaggttcag cgaggaccag tacgagctcc acatcccgat cgcgatcaac aagtgcccca     5040

agaacatctt caagatcaac accgaggtcc gcgtgctcct gaagcacgac gacaacccct     5100

acgtgatcgg catcgctagg ggcgagagga acctcctgta catcgtggtc gtggacggca     5160

agggcaacat cgtggagcag tactccctca acgagatcat caacaacttc aacggcatca     5220

ggatcaagac ggactaccac agcctcctgg acaagaagga gaaggagagg ttcgaggccc     5280

gccagaactg gacctccatc gagaacatca aggagctgaa ggcgggctac atcagccagg     5340

tcgtgcacaa gatctgcgag ctcgtcgaga agtacgacgc cgtgatcgcc ctcgcggacc     5400

tgaactccgg cttcaagaac agccgcgtca aggtggagaa gcaggtctac cagaagttcg     5460

agaagatgct catcgacaag ctgaactaca tggtggacaa gaagtccaac ccctgcgcta     5520

cgggcggcgc gctgaagggc taccagatca ccaacaagtt cgagagcttc aagtccatga     5580

gcactcagaa cggcttcatc ttctacatcc cggcgtggct cacgtccaag atcgacccca     5640

gcaccggctt cgtcaacctc ctgaagacga agtacacctc catcgccgac agcaagaagt     5700

tcatctccag cttcgaccgc atcatgtatg tgccggagga ggacctgttc gagttcgccc     5760

tcgactacaa gaacttctcc cgcacggacg cggactacat caagaagtgg aagctgtaca     5820

gctacggcaa ccgcatccgc atcttcagga accccaagaa gaacaacgtc ttcgactggg     5880

aggaggtgtg cctgacctcc gcgtacaagg agctcttcaa caagtacggc atcaactacc     5940

agcagggcga catcagggct ctcctgtgcg agcagagcga caaggccttc tactccagct     6000

tcatggcgct gatgtccctc atgctgcaga tgaggaactc gatcaccggc aggacggacg     6060

tggccttcct catctccccg gtgaagaaca gcgacggcat cttctacgac tccaggaact     6120

acgaggccca ggagaacgcg atcctcccaa agaacgcgga cgccaacggc gcctacaaca     6180

tcgccaggaa ggtcctctgg gctatcggcc agttcaagaa ggcggaggac gagaagctgg     6240

acaaggtgaa gatcgccatc agcaacaagg agtggctcga gtacgcccag acctcggtca     6300

agcacggcag cccgaagaag aagcgcaagg tgtccggcgg cagcacgaac ctgtccgaca     6360

tcatcgagaa ggagaccggc aagcagctcg tgatccagga gagcatcctc atgctgccgg     6420

aggaggtcga ggaggtcatc ggcaacaagc ccgagtccga catcctcgtc cacacggcct     6480

acgacgagtc caccgacgag aacgtgatgc tcctgacctc ggacgctccc gagtacaagc     6540

catgggccct ggtcatccag gacagcaacg gcgagaacaa gatcaagatg ctctccggcg     6600

gcagcccgaa gaagaagcgc aaagtgtgag atcgttcaaa catttggcaa taaagtttct     6660

taagattgaa tcctgttgcc ggtcttgcga tgattatcat ataatttctg ttgaattacg     6720

ttaagcatgt aataattaac atgtaatgca tgacgttatt tatgagatgg gtttttatga     6780

ttagagtccc gcaattatac atttaatacg cgatagaaaa caaaatatag cgcgcaaact     6840

aggataaatt atcgcgcgcg gtgtcatcta tgttactaga tc                        6882


<210>  10
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
gggggcgggg gctcaggcgg gggcgggagc ggcggcgggg gctctggggg cggcggcagc       60

ggcgggggcg gcagcggggg cggcgggtcg                                        90


<210>  11
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Gly Ser Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly 
        


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14
<211>  4842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized fusion

<400>  14
atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg gccccgtggc ggtggacccc       60

accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt tcttcgaccc cagggagctc      120

cgcaaggaga cctgcctcct gtacgagatc aactggggcg gcaggcactc catctggagg      180

cacacgagcc agaacaccaa caagcacgtc gaggtgaact tcatcgagaa gttcaccacg      240

gagaggtact tctgcccgaa cacgcgctgc tccatcacgt ggttcctctc gtggagccca      300

tgcggcgagt gctccagggc gatcacggag ttcctcagcc gctacccgca cgtgaccctg      360

ttcatctaca tcgctaggct ctaccaccac gcggacccca ggaacaggca gggcctcagg      420

gacctgatct ccagcggcgt cacgatccag atcatgaccg agcaggagtc cggctactgc      480

tggaggaact tcgtgaacta ctccccgagc aacgaggccc actggccccg ctacccgcac      540

ctctgggtcc gcctctacgt gctcgagctg tactgcatca tcctcggcct gccgccctgc      600

ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct tcaccatcgc cctgcagagc      660

tgccactacc agaggctccc gccccacatc ctgtgggcga ccgggctcaa gtcgggcagc      720

gagacccccg gcacctccga gtcggctacc ccagagtcca tgagcaagct ggagaagttc      780

acgaactgct actccctcag caagaccctg aggttcaagg cgatcccggt cggcaagacc      840

caggagaaca tcgacaacaa gcggctgctg gtggaggacg agaagagggc tgaggactac      900

aagggcgtga agaagctcct ggaccgctac tacctgtcct tcatcaacga cgtgctccac      960

agcatcaagc tcaagaacct gaacaactac atcagcctct tcaggaagaa gacgcgcacc     1020

gagaaggaga acaaggagct cgagaacctg gagatcaacc tgaggaagga gatcgccaag     1080

gcgttcaagg gcaacgaggg ctacaagtcc ctcttcaaga aggacatcat cgagacgatc     1140

ctcccggagt tcctggacga caaggacgag atcgccctgg tcaactcctt caacggcttc     1200

accacggcgt tcaccggctt cttcgacaac cgcgagaaca tgttcagcga ggaggccaag     1260

tccacgagca tcgcgttcag gtgcatcaac gagaacctca cccgctacat ctccaacatg     1320

gacatcttcg agaaggtcga cgcgatcttc gacaagcacg aggtgcagga gatcaaggag     1380

aagatcctga acagcgacta cgacgtcgag gacttcttcg agggcgagtt cttcaacttc     1440

gtcctcacgc aggagggcat cgacgtgtac aacgccatca tcggtggctt cgtgaccgag     1500

tccggcgaga agatcaaggg cctgaacgag tacatcaacc tctacaacca gaagaccaag     1560

cagaagctgc cgaagttcaa gcccctgtac aagcaggtgc tctccgacag ggagtccctc     1620

agcttctacg gcgagggcta cacgagcgac gaggaggtcc tggaggtgtt ccgcaacacc     1680

ctcaacaaga acagcgagat cttctccagc atcaagaagc tcgagaagct gttcaagaac     1740

ttcgacgagt actccagcgc cggcatcttc gtcaagaacg gcccggcgat ctccacgatc     1800

agcaaggaca tcttcggcga gtggaacgtg atccgcgaca agtggaacgc cgagtacgac     1860

gacatccacc tcaagaagaa ggcggtggtc accgagaagt acgaggacga caggcgcaag     1920

tccttcaaga agatcggctc cttcagcctc gagcagctgc aggagtacgc cgacgcggac     1980

ctgagcgtgg tcgagaagct caaggagatc atcatccaga aggtcgacga gatctacaag     2040

gtgtacggct ccagcgagaa gctcttcgac gcggacttcg tcctcgagaa gtccctgaag     2100

aagaacgacg ccgtggtcgc gatcatgaag gacctcctgg actccgtgaa gagcttcgag     2160

aattacatca aggccttctt cggcgagggc aaggagacga acagggacga gtccttctac     2220

ggcgacttcg tcctggccta cgacatcctc ctgaaggtgg accacatcta cgacgcgatc     2280

cgcaactacg tgacccagaa gccgtacagc aaggacaagt tcaagctcta cttccagaac     2340

ccccagttca tgggcggctg ggacaaggac aaggagacgg actacagggc gaccatcctg     2400

cgctacggca gcaagtacta cctcgccatc atggacaaga agtacgcgaa gtgcctgcag     2460

aagatcgaca aggacgacgt caacggcaac tacgagaaga tcaactacaa gctcctgccg     2520

ggccccaaca agatgctccc gaaggtgttc ttctccaaga agtggatggc ctactacaac     2580

cccagcgagg acatccagaa gatctacaag aacggcacgt tcaagaaggg cgacatgttc     2640

aacctgaacg actgccacaa gctcatcgac ttcttcaagg actccatcag ccgctacccg     2700

aagtggtcca acgcctacga cttcaacttc agcgagaccg agaagtacaa ggacatcgcg     2760

ggcttctacc gcgaggtcga ggagcagggc tacaaggtgt ccttcgagtc cgccagcaag     2820

aaggaggtcg acaagctggt ggaggagggc aagctctaca tgttccagat ctacaacaag     2880

gacttctccg acaagagcca cggcacgccc aacctgcaca ccatgtactt caagctcctg     2940

ttcgacgaga acaaccacgg ccagatcagg ctgtccggcg gcgccgagct cttcatgagg     3000

agggcgagcc tgaagaagga ggagctggtg gtccaccccg ctaacagccc aatcgcgaac     3060

aagaacccgg acaaccccaa gaagaccacg accctgtcct acgacgtgta caaggacaag     3120

aggttcagcg aggaccagta cgagctccac atcccgatcg cgatcaacaa gtgccccaag     3180

aacatcttca agatcaacac cgaggtccgc gtgctcctga agcacgacga caacccctac     3240

gtgatcggca tcgctagggg cgagaggaac ctcctgtaca tcgtggtcgt ggacggcaag     3300

ggcaacatcg tggagcagta ctccctcaac gagatcatca acaacttcaa cggcatcagg     3360

atcaagacgg actaccacag cctcctggac aagaaggaga aggagaggtt cgaggcccgc     3420

cagaactgga cctccatcga gaacatcaag gagctgaagg cgggctacat cagccaggtc     3480

gtgcacaaga tctgcgagct cgtcgagaag tacgacgccg tgatcgccct cgcggacctg     3540

aactccggct tcaagaacag ccgcgtcaag gtggagaagc aggtctacca gaagttcgag     3600

aagatgctca tcgacaagct gaactacatg gtggacaaga agtccaaccc ctgcgctacg     3660

ggcggcgcgc tgaagggcta ccagatcacc aacaagttcg agagcttcaa gtccatgagc     3720

actcagaacg gcttcatctt ctacatcccg gcgtggctca cgtccaagat cgaccccagc     3780

accggcttcg tcaacctcct gaagacgaag tacacctcca tcgccgacag caagaagttc     3840

atctccagct tcgaccgcat catgtatgtg ccggaggagg acctgttcga gttcgccctc     3900

gactacaaga acttctcccg cacggacgcg gactacatca agaagtggaa gctgtacagc     3960

tacggcaacc gcatccgcat cttcaggaac cccaagaaga acaacgtctt cgactgggag     4020

gaggtgtgcc tgacctccgc gtacaaggag ctcttcaaca agtacggcat caactaccag     4080

cagggcgaca tcagggctct cctgtgcgag cagagcgaca aggccttcta ctccagcttc     4140

atggcgctga tgtccctcat gctgcagatg aggaactcga tcaccggcag gacggacgtg     4200

gccttcctca tctccccggt gaagaacagc gacggcatct tctacgactc caggaactac     4260

gaggcccagg agaacgcgat cctcccaaag aacgcggacg ccaacggcgc ctacaacatc     4320

gccaggaagg tcctctgggc tatcggccag ttcaagaagg cggaggacga gaagctggac     4380

aaggtgaaga tcgccatcag caacaaggag tggctcgagt acgcccagac ctcggtcaag     4440

cacggcagcc cgaagaagaa gcgcaaggtg ggagggtcga caggaggcgg ttctggcgga     4500

ggttcaggtg gaggctcgag tggtacgaac ctgtccgaca tcatcgagaa ggagaccggc     4560

aagcagctcg tgatccagga gagcatcctc atgctgccgg aggaggtcga ggaggtcatc     4620

ggcaacaagc ccgagtccga catcctcgtc cacacggcct acgacgagtc caccgacgag     4680

aacgtgatgc tcctgacctc ggacgctccc gagtacaagc catgggccct ggtcatccag     4740

gacagcaacg gcgagaacaa gatcaagatg ctcggtggag gcggttcagg cggaggtggc     4800

tctggcggtg gcggatcgcc gaagaagaag cgcaaagtgt ga                        4842


<210>  15
<211>  1613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Pro Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val 
1               5                   10                  15      


Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu 
            20                  25                  30          


Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr 
        35                  40                  45              


Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln 
    50                  55                  60                  


Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr 
65                  70                  75                  80  


Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu 
                85                  90                  95      


Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu 
            100                 105                 110         


Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr 
        115                 120                 125             


His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser 
    130                 135                 140                 


Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys 
145                 150                 155                 160 


Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro 
                165                 170                 175     


Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys 
            180                 185                 190         


Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln 
        195                 200                 205             


Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln 
    210                 215                 220                 


Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser Gly Ser 
225                 230                 235                 240 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met Ser Lys 
                245                 250                 255     


Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe 
            260                 265                 270         


Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg 
        275                 280                 285             


Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys 
    290                 295                 300                 


Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His 
305                 310                 315                 320 


Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys 
                325                 330                 335     


Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile 
            340                 345                 350         


Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr 
        355                 360                 365             


Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe 
    370                 375                 380                 


Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe 
385                 390                 395                 400 


Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser 
                405                 410                 415     


Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn 
            420                 425                 430         


Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala 
        435                 440                 445             


Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn 
    450                 455                 460                 


Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe 
465                 470                 475                 480 


Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly 
                485                 490                 495     


Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile 
            500                 505                 510         


Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro 
        515                 520                 525             


Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly 
    530                 535                 540                 


Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr 
545                 550                 555                 560 


Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys 
                565                 570                 575     


Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys 
            580                 585                 590         


Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp 
        595                 600                 605             


Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu 
    610                 615                 620                 


Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys 
625                 630                 635                 640 


Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr 
                645                 650                 655     


Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile 
            660                 665                 670         


Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu 
        675                 680                 685             


Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala 
    690                 695                 700                 


Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu 
705                 710                 715                 720 


Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp 
                725                 730                 735     


Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys 
            740                 745                 750         


Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro 
        755                 760                 765             


Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met 
    770                 775                 780                 


Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu 
785                 790                 795                 800 


Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala 
                805                 810                 815     


Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu 
            820                 825                 830         


Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys 
        835                 840                 845             


Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp 
    850                 855                 860                 


Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe 
865                 870                 875                 880 


Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile 
                885                 890                 895     


Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu 
            900                 905                 910         


Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu 
        915                 920                 925             


Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp 
    930                 935                 940                 


Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys 
945                 950                 955                 960 


Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr 
                965                 970                 975     


Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg Leu Ser 
            980                 985                 990         


Gly Gly Ala Glu Leu Phe Met Arg  Arg Ala Ser Leu Lys  Lys Glu Glu 
        995                 1000                 1005             


Leu Val  Val His Pro Ala Asn  Ser Pro Ile Ala Asn  Lys Asn Pro 
    1010                 1015                 1020             


Asp Asn  Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
    1025                 1030                 1035             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1040                 1045                 1050             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1055                 1060                 1065             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1070                 1075                 1080             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1085                 1090                 1095             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1100                 1105                 1110             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1115                 1120                 1125             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1130                 1135                 1140             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1145                 1150                 1155             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1160                 1165                 1170             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1175                 1180                 1185             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1190                 1195                 1200             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1205                 1210                 1215             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1220                 1225                 1230             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1235                 1240                 1245             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1250                 1255                 1260             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1265                 1270                 1275             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1280                 1285                 1290             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1295                 1300                 1305             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1310                 1315                 1320             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1325                 1330                 1335             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1340                 1345                 1350             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1355                 1360                 1365             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1370                 1375                 1380             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1385                 1390                 1395             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1400                 1405                 1410             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1415                 1420                 1425             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1430                 1435                 1440             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1445                 1450                 1455             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1460                 1465                 1470             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1475                 1480                 1485             


Lys Val  Gly Gly Ser Thr Gly  Gly Gly Ser Gly Gly  Gly Ser Gly 
    1490                 1495                 1500             


Gly Gly  Ser Ser Gly Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1505                 1510                 1515             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1520                 1525                 1530             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1535                 1540                 1545             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1550                 1555                 1560             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1565                 1570                 1575             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Gly Gly 
    1580                 1585                 1590             


Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Pro Lys 
    1595                 1600                 1605             


Lys Lys  Arg Lys Val 
    1610             


<210>  16
<211>  5145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg gccccgtggc ggtggacccc       60

accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt tcttcgaccc cagggagctc      120

cgcaaggaga cctgcctcct gtacgagatc aactggggcg gcaggcactc catctggagg      180

cacacgagcc agaacaccaa caagcacgtc gaggtgaact tcatcgagaa gttcaccacg      240

gagaggtact tctgcccgaa cacgcgctgc tccatcacgt ggttcctctc gtggagccca      300

tgcggcgagt gctccagggc gatcacggag ttcctcagcc gctacccgca cgtgaccctg      360

ttcatctaca tcgctaggct ctaccaccac gcggacccca ggaacaggca gggcctcagg      420

gacctgatct ccagcggcgt cacgatccag atcatgaccg agcaggagtc cggctactgc      480

tggaggaact tcgtgaacta ctccccgagc aacgaggccc actggccccg ctacccgcac      540

ctctgggtcc gcctctacgt gctcgagctg tactgcatca tcctcggcct gccgccctgc      600

ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct tcaccatcgc cctgcagagc      660

tgccactacc agaggctccc gccccacatc ctgtgggcga ccgggctcaa ggggggcggg      720

ggctcaggcg ggggcgggag cggcggcggg ggctctgggg gcggcggcag cggcgggggc      780

ggcagcgggg gcggcgggtc gatgagcaag ctggagaagt tcacgaactg ctactccctc      840

agcaagaccc tgaggttcaa ggcgatcccg gtcggcaaga cccaggagaa catcgacaac      900

aagcggctgc tggtggagga cgagaagagg gctgaggact acaagggcgt gaagaagctc      960

ctggaccgct actacctgtc cttcatcaac gacgtgctcc acagcatcaa gctcaagaac     1020

ctgaacaact acatcagcct cttcaggaag aagacgcgca ccgagaagga gaacaaggag     1080

ctcgagaacc tggagatcaa cctgaggaag gagatcgcca aggcgttcaa gggcaacgag     1140

ggctacaagt ccctcttcaa gaaggacatc atcgagacga tcctcccgga gttcctggac     1200

gacaaggacg agatcgccct ggtcaactcc ttcaacggct tcaccacggc gttcaccggc     1260

ttcttcgaca accgcgagaa catgttcagc gaggaggcca agtccacgag catcgcgttc     1320

aggtgcatca acgagaacct cacccgctac atctccaaca tggacatctt cgagaaggtc     1380

gacgcgatct tcgacaagca cgaggtgcag gagatcaagg agaagatcct gaacagcgac     1440

tacgacgtcg aggacttctt cgagggcgag ttcttcaact tcgtcctcac gcaggagggc     1500

atcgacgtgt acaacgccat catcggtggc ttcgtgaccg agtccggcga gaagatcaag     1560

ggcctgaacg agtacatcaa cctctacaac cagaagacca agcagaagct gccgaagttc     1620

aagcccctgt acaagcaggt gctctccgac agggagtccc tcagcttcta cggcgagggc     1680

tacacgagcg acgaggaggt cctggaggtg ttccgcaaca ccctcaacaa gaacagcgag     1740

atcttctcca gcatcaagaa gctcgagaag ctgttcaaga acttcgacga gtactccagc     1800

gccggcatct tcgtcaagaa cggcccggcg atctccacga tcagcaagga catcttcggc     1860

gagtggaacg tgatccgcga caagtggaac gccgagtacg acgacatcca cctcaagaag     1920

aaggcggtgg tcaccgagaa gtacgaggac gacaggcgca agtccttcaa gaagatcggc     1980

tccttcagcc tcgagcagct gcaggagtac gccgacgcgg acctgagcgt ggtcgagaag     2040

ctcaaggaga tcatcatcca gaaggtcgac gagatctaca aggtgtacgg ctccagcgag     2100

aagctcttcg acgcggactt cgtcctcgag aagtccctga agaagaacga cgccgtggtc     2160

gcgatcatga aggacctcct ggactccgtg aagagcttcg agaattacat caaggccttc     2220

ttcggcgagg gcaaggagac gaacagggac gagtccttct acggcgactt cgtcctggcc     2280

tacgacatcc tcctgaaggt ggaccacatc tacgacgcga tccgcaacta cgtgacccag     2340

aagccgtaca gcaaggacaa gttcaagctc tacttccaga acccccagtt catgggcggc     2400

tgggacaagg acaaggagac ggactacagg gcgaccatcc tgcgctacgg cagcaagtac     2460

tacctcgcca tcatggacaa gaagtacgcg aagtgcctgc agaagatcga caaggacgac     2520

gtcaacggca actacgagaa gatcaactac aagctcctgc cgggccccaa caagatgctc     2580

ccgaaggtgt tcttctccaa gaagtggatg gcctactaca accccagcga ggacatccag     2640

aagatctaca agaacggcac gttcaagaag ggcgacatgt tcaacctgaa cgactgccac     2700

aagctcatcg acttcttcaa ggactccatc agccgctacc cgaagtggtc caacgcctac     2760

gacttcaact tcagcgagac cgagaagtac aaggacatcg cgggcttcta ccgcgaggtc     2820

gaggagcagg gctacaaggt gtccttcgag tccgccagca agaaggaggt cgacaagctg     2880

gtggaggagg gcaagctcta catgttccag atctacaaca aggacttctc cgacaagagc     2940

cacggcacgc ccaacctgca caccatgtac ttcaagctcc tgttcgacga gaacaaccac     3000

ggccagatca ggctgtccgg cggcgccgag ctcttcatga ggagggcgag cctgaagaag     3060

gaggagctgg tggtccaccc cgctaacagc ccaatcgcga acaagaaccc ggacaacccc     3120

aagaagacca cgaccctgtc ctacgacgtg tacaaggaca agaggttcag cgaggaccag     3180

tacgagctcc acatcccgat cgcgatcaac aagtgcccca agaacatctt caagatcaac     3240

accgaggtcc gcgtgctcct gaagcacgac gacaacccct acgtgatcgg catcgctagg     3300

ggcgagagga acctcctgta catcgtggtc gtggacggca agggcaacat cgtggagcag     3360

tactccctca acgagatcat caacaacttc aacggcatca ggatcaagac ggactaccac     3420

agcctcctgg acaagaagga gaaggagagg ttcgaggccc gccagaactg gacctccatc     3480

gagaacatca aggagctgaa ggcgggctac atcagccagg tcgtgcacaa gatctgcgag     3540

ctcgtcgaga agtacgacgc cgtgatcgcc ctcgcggacc tgaactccgg cttcaagaac     3600

agccgcgtca aggtggagaa gcaggtctac cagaagttcg agaagatgct catcgacaag     3660

ctgaactaca tggtggacaa gaagtccaac ccctgcgcta cgggcggcgc gctgaagggc     3720

taccagatca ccaacaagtt cgagagcttc aagtccatga gcactcagaa cggcttcatc     3780

ttctacatcc cggcgtggct cacgtccaag atcgacccca gcaccggctt cgtcaacctc     3840

ctgaagacga agtacacctc catcgccgac agcaagaagt tcatctccag cttcgaccgc     3900

atcatgtatg tgccggagga ggacctgttc gagttcgccc tcgactacaa gaacttctcc     3960

cgcacggacg cggactacat caagaagtgg aagctgtaca gctacggcaa ccgcatccgc     4020

atcttcagga accccaagaa gaacaacgtc ttcgactggg aggaggtgtg cctgacctcc     4080

gcgtacaagg agctcttcaa caagtacggc atcaactacc agcagggcga catcagggct     4140

ctcctgtgcg agcagagcga caaggccttc tactccagct tcatggcgct gatgtccctc     4200

atgctgcaga tgaggaactc gatcaccggc aggacggacg tggccttcct catctccccg     4260

gtgaagaaca gcgacggcat cttctacgac tccaggaact acgaggccca ggagaacgcg     4320

atcctcccaa agaacgcgga cgccaacggc gcctacaaca tcgccaggaa ggtcctctgg     4380

gctatcggcc agttcaagaa ggcggaggac gagaagctgg acaaggtgaa gatcgccatc     4440

agcaacaagg agtggctcga gtacgcccag acctcggtca agcacggcag cccgaagaag     4500

aagcgcaagg tgggagggtc gacaggaggc ggttctggcg gaggttcagg tggaggctcg     4560

agtggtacga acctgtccga catcatcgag aaggagaccg gcaagcagct cgtgatccag     4620

gagagcatcc tcatgctgcc ggaggaggtc gaggaggtca tcggcaacaa gcccgagtcc     4680

gacatcctcg tccacacggc ctacgacgag tccaccgacg agaacgtgat gctcctgacc     4740

tcggacgctc ccgagtacaa gccatgggcc ctggtcatcc aggacagcaa cggcgagaac     4800

aagatcaaga tgctcggtgg aggcggttca ggcggaggtg gctctggcgg tggcggatcg     4860

acgaacctgt ccgacatcat cgagaaggag accggcaagc agctcgtgat ccaggagagc     4920

atcctcatgc tgccggagga ggtcgaggag gtcatcggca acaagcccga gtccgacatc     4980

ctcgtccaca cggcctacga cgagtccacc gacgagaacg tgatgctcct gacctcggac     5040

gctcccgagt acaagccatg ggccctggtc atccaggaca gcaacggcga gaacaagatc     5100

aagatgctct ccggcggcag cccgaagaag aagcgcaaag tgtga                     5145


<210>  17
<211>  1714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Pro Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val 
1               5                   10                  15      


Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu 
            20                  25                  30          


Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr 
        35                  40                  45              


Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln 
    50                  55                  60                  


Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr 
65                  70                  75                  80  


Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu 
                85                  90                  95      


Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu 
            100                 105                 110         


Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr 
        115                 120                 125             


His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser 
    130                 135                 140                 


Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys 
145                 150                 155                 160 


Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro 
                165                 170                 175     


Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys 
            180                 185                 190         


Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln 
        195                 200                 205             


Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln 
    210                 215                 220                 


Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Lys Leu Glu 
            260                 265                 270         


Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala 
        275                 280                 285             


Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu 
    290                 295                 300                 


Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu 
305                 310                 315                 320 


Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile 
                325                 330                 335     


Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr 
            340                 345                 350         


Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu 
        355                 360                 365             


Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser 
    370                 375                 380                 


Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp 
385                 390                 395                 400 


Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr 
                405                 410                 415     


Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu 
            420                 425                 430         


Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr 
        435                 440                 445             


Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe 
    450                 455                 460                 


Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp 
465                 470                 475                 480 


Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu 
                485                 490                 495     


Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val 
            500                 505                 510         


Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu 
        515                 520                 525             


Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr 
    530                 535                 540                 


Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly 
545                 550                 555                 560 


Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn 
                565                 570                 575     


Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe 
            580                 585                 590         


Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly 
        595                 600                 605             


Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val 
    610                 615                 620                 


Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys 
625                 630                 635                 640 


Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe 
                645                 650                 655     


Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp 
            660                 665                 670         


Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys 
        675                 680                 685             


Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp 
    690                 695                 700                 


Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val 
705                 710                 715                 720 


Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr 
                725                 730                 735     


Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser 
            740                 745                 750         


Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp 
        755                 760                 765             


His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser 
    770                 775                 780                 


Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly 
785                 790                 795                 800 


Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr 
                805                 810                 815     


Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys 
            820                 825                 830         


Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile 
        835                 840                 845             


Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe 
    850                 855                 860                 


Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln 
865                 870                 875                 880 


Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu 
                885                 890                 895     


Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg 
            900                 905                 910         


Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu 
        915                 920                 925             


Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly 
    930                 935                 940                 


Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu 
945                 950                 955                 960 


Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe 
                965                 970                 975     


Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys 
            980                 985                 990         


Leu Leu Phe Asp Glu Asn Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly 
        995                 1000                 1005             


Ala Glu  Leu Phe Met Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu 
    1010                 1015                 1020             


Val Val  His Pro Ala Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp 
    1025                 1030                 1035             


Asn Pro  Lys Lys Thr Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp 
    1040                 1045                 1050             


Lys Arg  Phe Ser Glu Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala 
    1055                 1060                 1065             


Ile Asn  Lys Cys Pro Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val 
    1070                 1075                 1080             


Arg Val  Leu Leu Lys His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile 
    1085                 1090                 1095             


Ala Arg  Gly Glu Arg Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly 
    1100                 1105                 1110             


Lys Gly  Asn Ile Val Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn 
    1115                 1120                 1125             


Asn Phe  Asn Gly Ile Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu 
    1130                 1135                 1140             


Asp Lys  Lys Glu Lys Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr 
    1145                 1150                 1155             


Ser Ile  Glu Asn Ile Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln 
    1160                 1165                 1170             


Val Val  His Lys Ile Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val 
    1175                 1180                 1185             


Ile Ala  Leu Ala Asp Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val 
    1190                 1195                 1200             


Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile 
    1205                 1210                 1215             


Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala 
    1220                 1225                 1230             


Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu 
    1235                 1240                 1245             


Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile 
    1250                 1255                 1260             


Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val 
    1265                 1270                 1275             


Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys 
    1280                 1285                 1290             


Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp 
    1295                 1300                 1305             


Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp 
    1310                 1315                 1320             


Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg 
    1325                 1330                 1335             


Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp 
    1340                 1345                 1350             


Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys 
    1355                 1360                 1365             


Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys 
    1370                 1375                 1380             


Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met 
    1385                 1390                 1395             


Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile Thr Gly  Arg Thr Asp 
    1400                 1405                 1410             


Val Ala  Phe Leu Ile Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe 
    1415                 1420                 1425             


Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro 
    1430                 1435                 1440             


Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val 
    1445                 1450                 1455             


Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu 
    1460                 1465                 1470             


Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr 
    1475                 1480                 1485             


Ala Gln  Thr Ser Val Lys His  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1490                 1495                 1500             


Val Gly  Gly Ser Thr Gly Gly  Gly Ser Gly Gly Gly  Ser Gly Gly 
    1505                 1510                 1515             


Gly Ser  Ser Gly Thr Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr 
    1520                 1525                 1530             


Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu 
    1535                 1540                 1545             


Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu 
    1550                 1555                 1560             


Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu 
    1565                 1570                 1575             


Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile 
    1580                 1585                 1590             


Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys Met Leu  Gly Gly Gly 
    1595                 1600                 1605             


Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Thr Asn Leu 
    1610                 1615                 1620             


Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln 
    1625                 1630                 1635             


Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly 
    1640                 1645                 1650             


Asn Lys  Pro Glu Ser Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu 
    1655                 1660                 1665             


Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu 
    1670                 1675                 1680             


Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn 
    1685                 1690                 1695             


Lys Ile  Lys Met Leu Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1700                 1705                 1710             


Val 
    


<210>  18
<211>  4767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg gccccgtggc ggtggacccc       60

accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt tcttcgaccc cagggagctc      120

cgcaaggaga cctgcctcct gtacgagatc aactggggcg gcaggcactc catctggagg      180

cacacgagcc agaacaccaa caagcacgtc gaggtgaact tcatcgagaa gttcaccacg      240

gagaggtact tctgcccgaa cacgcgctgc tccatcacgt ggttcctctc gtggagccca      300

tgcggcgagt gctccagggc gatcacggag ttcctcagcc gctacccgca cgtgaccctg      360

ttcatctaca tcgctaggct ctaccaccac gcggacccca ggaacaggca gggcctcagg      420

gacctgatct ccagcggcgt cacgatccag atcatgaccg agcaggagtc cggctactgc      480

tggaggaact tcgtgaacta ctccccgagc aacgaggccc actggccccg ctacccgcac      540

ctctgggtcc gcctctacgt gctcgagctg tactgcatca tcctcggcct gccgccctgc      600

ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct tcaccatcgc cctgcagagc      660

tgccactacc agaggctccc gccccacatc ctgtgggcga ccgggctcaa gtcgggcagc      720

gagacccccg gcacctccga gtcggctacc ccagagtcca tgagcaagct ggagaagttc      780

acgaactgct actccctcag caagaccctg aggttcaagg cgatcccggt cggcaagacc      840

caggagaaca tcgacaacaa gcggctgctg gtggaggacg agaagagggc tgaggactac      900

aagggcgtga agaagctcct ggaccgctac tacctgtcct tcatcaacga cgtgctccac      960

agcatcaagc tcaagaacct gaacaactac atcagcctct tcaggaagaa gacgcgcacc     1020

gagaaggaga acaaggagct cgagaacctg gagatcaacc tgaggaagga gatcgccaag     1080

gcgttcaagg gcaacgaggg ctacaagtcc ctcttcaaga aggacatcat cgagacgatc     1140

ctcccggagt tcctggacga caaggacgag atcgccctgg tcaactcctt caacggcttc     1200

accacggcgt tcaccggctt cttcgacaac cgcgagaaca tgttcagcga ggaggccaag     1260

tccacgagca tcgcgttcag gtgcatcaac gagaacctca cccgctacat ctccaacatg     1320

gacatcttcg agaaggtcga cgcgatcttc gacaagcacg aggtgcagga gatcaaggag     1380

aagatcctga acagcgacta cgacgtcgag gacttcttcg agggcgagtt cttcaacttc     1440

gtcctcacgc aggagggcat cgacgtgtac aacgccatca tcggtggctt cgtgaccgag     1500

tccggcgaga agatcaaggg cctgaacgag tacatcaacc tctacaacca gaagaccaag     1560

cagaagctgc cgaagttcaa gcccctgtac aagcaggtgc tctccgacag ggagtccctc     1620

agcttctacg gcgagggcta cacgagcgac gaggaggtcc tggaggtgtt ccgcaacacc     1680

ctcaacaaga acagcgagat cttctccagc atcaagaagc tcgagaagct gttcaagaac     1740

ttcgacgagt actccagcgc cggcatcttc gtcaagaacg gcccggcgat ctccacgatc     1800

agcaaggaca tcttcggcga gtggaacgtg atccgcgaca agtggaacgc cgagtacgac     1860

gacatccacc tcaagaagaa ggcggtggtc accgagaagt acgaggacga caggcgcaag     1920

tccttcaaga agatcggctc cttcagcctc gagcagctgc aggagtacgc cgacgcggac     1980

ctgagcgtgg tcgagaagct caaggagatc atcatccaga aggtcgacga gatctacaag     2040

gtgtacggct ccagcgagaa gctcttcgac gcggacttcg tcctcgagaa gtccctgaag     2100

aagaacgacg ccgtggtcgc gatcatgaag gacctcctgg actccgtgaa gagcttcgag     2160

aattacatca aggccttctt cggcgagggc aaggagacga acagggacga gtccttctac     2220

ggcgacttcg tcctggccta cgacatcctc ctgaaggtgg accacatcta cgacgcgatc     2280

cgcaactacg tgacccagaa gccgtacagc aaggacaagt tcaagctcta cttccagaac     2340

ccccagttca tgggcggctg ggacaaggac aaggagacgg actacagggc gaccatcctg     2400

cgctacggca gcaagtacta cctcgccatc atggacaaga agtacgcgaa gtgcctgcag     2460

aagatcgaca aggacgacgt caacggcaac tacgagaaga tcaactacaa gctcctgccg     2520

ggccccaaca agatgctccc gaaggtgttc ttctccaaga agtggatggc ctactacaac     2580

cccagcgagg acatccagaa gatctacaag aacggcacgt tcaagaaggg cgacatgttc     2640

aacctgaacg actgccacaa gctcatcgac ttcttcaagg actccatcag ccgctacccg     2700

aagtggtcca acgcctacga cttcaacttc agcgagaccg agaagtacaa ggacatcgcg     2760

ggcttctacc gcgaggtcga ggagcagggc tacaaggtgt ccttcgagtc cgccagcaag     2820

aaggaggtcg acaagctggt ggaggagggc aagctctaca tgttccagat ctacaacaag     2880

gacttctccg acaagagcca cggcacgccc aacctgcaca ccatgtactt caagctcctg     2940

ttcgacgaga acaaccacgg ccagatcagg ctgtccggcg gcgccgagct cttcatgagg     3000

agggcgagcc tgaagaagga ggagctggtg gtccaccccg ctaacagccc aatcgcgaac     3060

aagaacccgg acaaccccaa gaagaccacg accctgtcct acgacgtgta caaggacaag     3120

aggttcagcg aggaccagta cgagctccac atcccgatcg cgatcaacaa gtgccccaag     3180

aacatcttca agatcaacac cgaggtccgc gtgctcctga agcacgacga caacccctac     3240

gtgatcggca tcgctagggg cgagaggaac ctcctgtaca tcgtggtcgt ggacggcaag     3300

ggcaacatcg tggagcagta ctccctcaac gagatcatca acaacttcaa cggcatcagg     3360

atcaagacgg actaccacag cctcctggac aagaaggaga aggagaggtt cgaggcccgc     3420

cagaactgga cctccatcga gaacatcaag gagctgaagg cgggctacat cagccaggtc     3480

gtgcacaaga tctgcgagct cgtcgagaag tacgacgccg tgatcgccct cgcggacctg     3540

aactccggct tcaagaacag ccgcgtcaag gtggagaagc aggtctacca gaagttcgag     3600

aagatgctca tcgacaagct gaactacatg gtggacaaga agtccaaccc ctgcgctacg     3660

ggcggcgcgc tgaagggcta ccagatcacc aacaagttcg agagcttcaa gtccatgagc     3720

actcagaacg gcttcatctt ctacatcccg gcgtggctca cgtccaagat cgaccccagc     3780

accggcttcg tcaacctcct gaagacgaag tacacctcca tcgccgacag caagaagttc     3840

atctccagct tcgaccgcat catgtatgtg ccggaggagg acctgttcga gttcgccctc     3900

gactacaaga acttctcccg cacggacgcg gactacatca agaagtggaa gctgtacagc     3960

tacggcaacc gcatccgcat cttcaggaac cccaagaaga acaacgtctt cgactgggag     4020

gaggtgtgcc tgacctccgc gtacaaggag ctcttcaaca agtacggcat caactaccag     4080

cagggcgaca tcagggctct cctgtgcgag cagagcgaca aggccttcta ctccagcttc     4140

atggcgctga tgtccctcat gctgcagatg aggaactcga tcaccggcag gacggacgtg     4200

gccttcctca tctccccggt gaagaacagc gacggcatct tctacgactc caggaactac     4260

gaggcccagg agaacgcgat cctcccaaag aacgcggacg ccaacggcgc ctacaacatc     4320

gccaggaagg tcctctgggc tatcggccag ttcaagaagg cggaggacga gaagctggac     4380

aaggtgaaga tcgccatcag caacaaggag tggctcgagt acgcccagac ctcggtcaag     4440

cacggcagcc cgaagaagaa gcgcaaggtg tccggcggca gcacgaacct gtccgacatc     4500

atcgagaagg agaccggcaa gcagctcgtg atccaggaga gcatcctcat gctgccggag     4560

gaggtcgagg aggtcatcgg caacaagccc gagtccgaca tcctcgtcca cacggcctac     4620

gacgagtcca ccgacgagaa cgtgatgctc ctgacctcgg acgctcccga gtacaagcca     4680

tgggccctgg tcatccagga cagcaacggc gagaacaaga tcaagatgct ctccggcggc     4740

agcccgaaga agaagcgcaa agtgtga                                         4767


<210>  19
<211>  1588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Pro Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val 
1               5                   10                  15      


Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu 
            20                  25                  30          


Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr 
        35                  40                  45              


Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln 
    50                  55                  60                  


Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr 
65                  70                  75                  80  


Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu 
                85                  90                  95      


Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu 
            100                 105                 110         


Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr 
        115                 120                 125             


His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser 
    130                 135                 140                 


Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys 
145                 150                 155                 160 


Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro 
                165                 170                 175     


Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys 
            180                 185                 190         


Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln 
        195                 200                 205             


Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln 
    210                 215                 220                 


Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser Gly Ser 
225                 230                 235                 240 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met Ser Lys 
                245                 250                 255     


Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe 
            260                 265                 270         


Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg 
        275                 280                 285             


Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys 
    290                 295                 300                 


Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His 
305                 310                 315                 320 


Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys 
                325                 330                 335     


Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile 
            340                 345                 350         


Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr 
        355                 360                 365             


Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe 
    370                 375                 380                 


Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe 
385                 390                 395                 400 


Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser 
                405                 410                 415     


Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn 
            420                 425                 430         


Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala 
        435                 440                 445             


Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn 
    450                 455                 460                 


Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe 
465                 470                 475                 480 


Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly 
                485                 490                 495     


Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile 
            500                 505                 510         


Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro 
        515                 520                 525             


Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly 
    530                 535                 540                 


Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr 
545                 550                 555                 560 


Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys 
                565                 570                 575     


Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys 
            580                 585                 590         


Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp 
        595                 600                 605             


Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu 
    610                 615                 620                 


Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys 
625                 630                 635                 640 


Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr 
                645                 650                 655     


Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile 
            660                 665                 670         


Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu 
        675                 680                 685             


Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala 
    690                 695                 700                 


Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu 
705                 710                 715                 720 


Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp 
                725                 730                 735     


Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys 
            740                 745                 750         


Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro 
        755                 760                 765             


Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met 
    770                 775                 780                 


Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu 
785                 790                 795                 800 


Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala 
                805                 810                 815     


Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu 
            820                 825                 830         


Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys 
        835                 840                 845             


Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp 
    850                 855                 860                 


Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe 
865                 870                 875                 880 


Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile 
                885                 890                 895     


Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu 
            900                 905                 910         


Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu 
        915                 920                 925             


Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp 
    930                 935                 940                 


Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys 
945                 950                 955                 960 


Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr 
                965                 970                 975     


Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg Leu Ser 
            980                 985                 990         


Gly Gly Ala Glu Leu Phe Met Arg  Arg Ala Ser Leu Lys  Lys Glu Glu 
        995                 1000                 1005             


Leu Val  Val His Pro Ala Asn  Ser Pro Ile Ala Asn  Lys Asn Pro 
    1010                 1015                 1020             


Asp Asn  Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
    1025                 1030                 1035             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1040                 1045                 1050             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1055                 1060                 1065             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1070                 1075                 1080             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1085                 1090                 1095             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1100                 1105                 1110             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1115                 1120                 1125             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1130                 1135                 1140             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1145                 1150                 1155             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1160                 1165                 1170             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1175                 1180                 1185             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1190                 1195                 1200             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1205                 1210                 1215             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1220                 1225                 1230             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1235                 1240                 1245             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1250                 1255                 1260             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1265                 1270                 1275             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1280                 1285                 1290             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1295                 1300                 1305             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1310                 1315                 1320             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1325                 1330                 1335             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1340                 1345                 1350             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1355                 1360                 1365             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1370                 1375                 1380             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1385                 1390                 1395             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1400                 1405                 1410             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1415                 1420                 1425             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1430                 1435                 1440             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1445                 1450                 1455             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1460                 1465                 1470             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1475                 1480                 1485             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1490                 1495                 1500             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1505                 1510                 1515             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1520                 1525                 1530             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1535                 1540                 1545             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1550                 1555                 1560             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1565                 1570                 1575             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1580                 1585             


<210>  20
<211>  5229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
atgccgaaga agaagcgcaa ggtgtccagc gagaccggcc ccgtggcggt cgaccccacc       60

ctgcgcaggc gcatcgagcc gcacgagttc gaggtcttct tcgaccccag ggagctccgc      120

aaggagacct gcctcctgta cgagatcaac tggggcggca ggcactccat ctggaggcac      180

accagccaga acacgaacaa gcacgtggag gtcaacttca tcgagaagtt caccacggag      240

aggtacttct gcccgaacac ccgctgctcc atcacctggt tcctctcgtg gagcccatgc      300

ggcgagtgct ccagggcgat cacggagttc ctcagccgct acccgcacgt gaccctcttc      360

atctacatcg ctaggctgta ccaccacgcg gaccccagga acaggcaggg gctcagggac      420

ctgatctcca gcggcgtgac catccagatc atgacggagc aggagtccgg ctactgctgg      480

cgcaacttcg tcaactactc cccgagcaac gaggcccact ggccccgcta cccgcacctg      540

tgggtgcgcc tctacgtcct cgagctgtac tgcatcatcc tcggcctgcc gccctgcctc      600

aacatcctga ggcgcaagca gccccagctc accttcttca cgatcgccct gcagagctgc      660

cactaccagc ggctgccgcc ccacatcctc tgggccaccg gcctgaagtc gggcagcgag      720

acgcccggca cgtccgagtc ggctacccca gagctcaagg acaagaagta cagcatcggc      780

ctggcaatcg gcaccaacag cgtgggctgg gccgtgatca ccgacgagta caaggtgccg      840

agcaagaagt tcaaggtgct gggcaacacc gacaggcaca gcatcaagaa gaacctgatc      900

ggcgccctgc tgttcgacag cggcgagacc gccgaggcca ccaggctgaa gaggaccgcc      960

aggaggaggt acaccaggag gaagaacagg atctgctacc tgcaggagat cttcagcaac     1020

gagatggcca aggtggacga cagcttcttc cacaggctgg aggagagctt cctggtggag     1080

gaggacaaga agcacgagag gcacccgatc ttcggcaaca tcgtggacga ggtggcctac     1140

cacgagaagt acccgaccat ctaccacctg aggaagaagc tggtggacag caccgacaag     1200

gccgacctga ggctgatcta cctggccctg gcccacatga tcaagttcag gggccacttc     1260

ctgatcgagg gcgacctgaa cccggacaac agcgacgtgg acaagctgtt catccagctg     1320

gtgcagacct acaaccagct gttcgaggag aacccgatca acgccagcgg cgtggacgcc     1380

aaggccatcc tgagcgccag gctgagcaag agcaggaggc tggagaacct gatcgcccag     1440

ctgccgggcg agaagaagaa cggcctgttc ggcaacctga tcgccctgag cctgggcctg     1500

accccgaact tcaagagcaa cttcgacctg gccgaggacg ccaagctgca gctgagcaag     1560

gacacctacg acgacgacct ggacaacctg ctggcccaga tcggcgacca gtacgccgac     1620

ctgttcctgg ccgccaagaa cctgagcgac gccatcctgc tgagcgacat cctgagggtg     1680

aacaccgaga tcaccaaggc cccgctgagc gccagcatga tcaagaggta cgacgagcac     1740

caccaggacc tgaccctgct gaaggccctg gtgaggcagc agctgccgga gaagtacaag     1800

gagatcttct tcgaccagag caagaacggc tacgccggct acatcgacgg cggcgccagc     1860

caggaggagt tctacaagtt catcaagccg atcctggaga agatggacgg caccgaggag     1920

ctgctggtga agctgaacag ggaggacctg ctgaggaagc agaggacctt cgacaacggc     1980

agcatcccgc accagatcca cctgggcgag ctgcacgcca tcctgaggag gcaggaggac     2040

ttctacccgt tcctgaagga caacagggag aagatcgaga agatcctgac cttccgcatc     2100

ccgtactacg tgggcccgct ggccaggggc aacagcaggt tcgcctggat gaccaggaag     2160

agcgaggaga ccatcacccc gtggaacttc gaggaggtgg tggacaaggg cgccagcgcc     2220

cagagcttca tcgagaggat gaccaacttc gacaagaacc tgccgaacga gaaggtgctg     2280

ccgaagcaca gcctgctgta cgagtacttc accgtgtaca acgagctgac caaggtgaag     2340

tacgtgaccg agggcatgag gaagccggcc ttcctgagcg gcgagcagaa gaaggccatc     2400

gtggacctgc tgttcaagac caacaggaag gtgaccgtga agcagctgaa ggaggactac     2460

ttcaagaaga tcgagtgctt cgacagcgtg gagatcagcg gcgtggagga caggttcaac     2520

gccagcctgg gcacctacca cgacctgctg aagatcatca aggacaagga cttcctggac     2580

aacgaggaga acgaggacat cctggaggac atcgtgctga ccctgaccct gttcgaggac     2640

agggagatga tcgaggagag gctgaagacc tacgcccacc tgttcgacga caaggtgatg     2700

aagcagctga agaggaggag gtacaccggc tggggcaggc tgagcaggaa gctgatcaac     2760

ggcatcaggg acaagcagag cggcaagacc atcctggact tcctgaagag cgacggcttc     2820

gccaacagga acttcatgca gctgatccac gacgacagcc tgaccttcaa ggaggacatc     2880

cagaaggccc aggtgagcgg ccagggcgac agcctgcacg agcacatcgc caacctggcc     2940

ggcagcccgg ccatcaagaa gggcatcctg cagaccgtga aggtggtgga cgagctggtg     3000

aaggtgatgg gcaggcacaa gccggagaac atcgtgatcg agatggccag ggagaaccag     3060

accacccaga agggccagaa gaacagcagg gagaggatga agaggatcga ggagggcatc     3120

aaggagctgg gcagccagat cctgaaggag cacccggtgg agaacaccca gctgcagaac     3180

gagaagctgt acctgtacta cctgcagaac ggcagggaca tgtacgtgga ccaggagctg     3240

gacatcaaca ggctgagcga ctacgacgtg gaccacatcg tgccgcagag cttcctgaag     3300

gacgacagca tcgacaacaa ggtgctgacc aggagcgaca agaacagggg caagagcgac     3360

aacgtgccga gcgaggaggt ggtgaagaag atgaaaaact actggaggca gctgctgaac     3420

gccaagctga tcacccagag gaagttcgac aacctgacca aggccgagag gggcggcctg     3480

agcgagctgg acaaggccgg cttcattaaa aggcagctgg tggagaccag gcagatcacc     3540

aagcacgtgg cccagatcct ggacagcagg atgaacacca agtacgacga gaacgacaag     3600

ctgatcaggg aggtgaaggt gatcaccctg aagagcaagc tggtgagcga cttcaggaag     3660

gacttccagt tctacaaggt gagggagatc aataattacc accacgccca cgacgcctac     3720

ctgaacgccg tggtgggcac cgccctgatt aaaaagtacc cgaagctgga gagcgagttc     3780

gtgtacggcg actacaaggt gtacgacgtg aggaagatga tcgccaagag cgagcaggag     3840

atcggcaagg ccaccgccaa gtacttcttc tacagcaaca tcatgaactt cttcaagacc     3900

gagatcaccc tggccaacgg cgagatcagg aagaggccgc tgatcgagac caacggcgag     3960

accggcgaga tcgtgtggga caagggcagg gacttcgcca ccgtgaggaa ggtgctgtcc     4020

atgccgcagg tgaacatcgt gaagaagacc gaggtgcaga ccggcggctt cagcaaggag     4080

agcatcctgc cgaagaggaa cagcgacaag ctgatcgcca ggaagaagga ctgggatccg     4140

aagaagtacg gcggcttcga cagcccgacc gtggcctaca gcgtgctggt ggtggccaag     4200

gtggagaagg gcaagagcaa gaagctgaag agcgtgaagg agctggtggg catcaccatc     4260

atggagagga gcagcttcga gaagaaccca gtggacttcc tggaggccaa gggctacaag     4320

gaggtgaaga aggacctgat cattaaactg ccgaagtaca gcctgttcga gctggagaac     4380

ggcaggaaga ggatgctggc cagcgccggc gagctgcaga agggcaacga gctggccctg     4440

ccgagcaagt acgtgaactt cctgtacctg gccagccact acgagaagct gaagggcagc     4500

ccggaggaca acgagcagaa gcagctgttc gtggagcagc acaagcacta cctggacgag     4560

atcatcgagc agatcagcga gttcagcaag agggtgatcc tggccgacgc caacctggac     4620

aaggtgctga gcgcctacaa caagcacagg gacaagccga tcagggagca ggccgagaac     4680

atcatccacc tgttcaccct gaccaacctg ggcgccccgg ccgccttcaa gtacttcgac     4740

accaccatcg acaggaagag gtacaccagc accaaggagg tgctggacgc caccctgatc     4800

caccagagca tcaccggcct gtacgagacc aggatcgacc tgagccagct gggcggcgac     4860

agcagcccgc cgaagaagaa gaggaaggtg agctggaagg acgccagcgg ctggagcagg     4920

atgaccaggg actccggcgg cagcaccaac ctctccgaca tcatcgagaa ggagacgggc     4980

aagcagctcg tgatccagga gagcatcctc atgctgccgg aggaggtgga ggaggtcatc     5040

ggcaacaagc ccgagtccga catcctcgtg cacacggcct acgacgagtc caccgacgag     5100

aacgtcatgc tcctgacctc ggacgctccc gagtacaagc catgggccct cgtgatccag     5160

gacagcaacg gcgagaacaa gatcaagatg ctctccggcg gcagcccgaa gaagaagcgc     5220

aaagtctga                                                             5229


<210>  21
<211>  1742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Pro Lys Lys Lys Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala 
1               5                   10                  15      


Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val 
            20                  25                  30          


Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu 
        35                  40                  45              


Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln Asn 
    50                  55                  60                  


Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu 
65                  70                  75                  80  


Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser 
                85                  90                  95      


Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser 
            100                 105                 110         


Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His 
        115                 120                 125             


His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser 
    130                 135                 140                 


Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp 
145                 150                 155                 160 


Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg 
                165                 170                 175     


Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile 
            180                 185                 190         


Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro 
        195                 200                 205             


Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg 
    210                 215                 220                 


Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Leu Lys Asp Lys Lys 
                245                 250                 255     


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
            260                 265                 270         


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
        275                 280                 285             


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
    290                 295                 300                 


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
305                 310                 315                 320 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
                325                 330                 335     


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
            340                 345                 350         


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
        355                 360                 365             


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
    370                 375                 380                 


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
385                 390                 395                 400 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                405                 410                 415     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            420                 425                 430         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        435                 440                 445             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    450                 455                 460                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
465                 470                 475                 480 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                485                 490                 495     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            500                 505                 510         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        515                 520                 525             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    530                 535                 540                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
545                 550                 555                 560 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                565                 570                 575     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            580                 585                 590         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        595                 600                 605             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    610                 615                 620                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
625                 630                 635                 640 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                645                 650                 655     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            660                 665                 670         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        675                 680                 685             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    690                 695                 700                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
705                 710                 715                 720 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                725                 730                 735     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            740                 745                 750         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        755                 760                 765             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    770                 775                 780                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
785                 790                 795                 800 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                805                 810                 815     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            820                 825                 830         


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
        835                 840                 845             


Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn 
    850                 855                 860                 


Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp 
865                 870                 875                 880 


Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp 
                885                 890                 895     


Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly 
            900                 905                 910         


Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly 
        915                 920                 925             


Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn 
    930                 935                 940                 


Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile 
945                 950                 955                 960 


Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile 
                965                 970                 975     


Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr 
            980                 985                 990         


Val Lys Val Val Asp Glu Leu Val  Lys Val Met Gly Arg  His Lys Pro 
        995                 1000                 1005             


Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln 
    1010                 1015                 1020             


Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu 
    1025                 1030                 1035             


Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu Lys Glu  His Pro Val 
    1040                 1045                 1050             


Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu 
    1055                 1060                 1065             


Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn 
    1070                 1075                 1080             


Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile Val Pro  Gln Ser Phe 
    1085                 1090                 1095             


Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp 
    1100                 1105                 1110             


Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro Ser Glu  Glu Val Val 
    1115                 1120                 1125             


Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu 
    1130                 1135                 1140             


Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly 
    1145                 1150                 1155             


Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
    1160                 1165                 1170             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1175                 1180                 1185             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1190                 1195                 1200             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1205                 1210                 1215             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1220                 1225                 1230             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1235                 1240                 1245             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1250                 1255                 1260             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1265                 1270                 1275             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1280                 1285                 1290             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1295                 1300                 1305             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1310                 1315                 1320             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1325                 1330                 1335             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1340                 1345                 1350             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1355                 1360                 1365             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1370                 1375                 1380             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1385                 1390                 1395             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1400                 1405                 1410             


Glu Leu  Val Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1415                 1420                 1425             


Asn Pro  Val Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1430                 1435                 1440             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1445                 1450                 1455             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1460                 1465                 1470             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1475                 1480                 1485             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1490                 1495                 1500             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1505                 1510                 1515             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1520                 1525                 1530             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1535                 1540                 1545             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1550                 1555                 1560             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1565                 1570                 1575             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1580                 1585                 1590             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1595                 1600                 1605             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Ser Ser Pro 
    1610                 1615                 1620             


Pro Lys  Lys Lys Arg Lys Val  Ser Trp Lys Asp Ala  Ser Gly Trp 
    1625                 1630                 1635             


Ser Arg  Met Thr Arg Asp Ser  Gly Gly Ser Thr Asn  Leu Ser Asp 
    1640                 1645                 1650             


Ile Ile  Glu Lys Glu Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser 
    1655                 1660                 1665             


Ile Leu  Met Leu Pro Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys 
    1670                 1675                 1680             


Pro Glu  Ser Asp Ile Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr 
    1685                 1690                 1695             


Asp Glu  Asn Val Met Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys 
    1700                 1705                 1710             


Pro Trp  Ala Leu Val Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile 
    1715                 1720                 1725             


Lys Met  Leu Ser Gly Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1730                 1735                 1740         


<210>  22
<211>  1316
<212>  PRT
<213>  Acidaminococcus fermentans

<400>  22

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Ala Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Ala Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Ala  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn Gly 
    1295                 1300                 1305             


Ser Pro  Lys Lys Lys Arg Lys  Val 
    1310                 1315     


<210>  23
<211>  4809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized

<400>  23
atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg gccccgtggc ggtggacccc       60

accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt tcttcgaccc cagggagctc      120

cgcaaggaga cctgcctcct gtacgagatc aactggggcg gcaggcactc catctggagg      180

cacacgagcc agaacaccaa caagcacgtc gaggtgaact tcatcgagaa gttcaccacg      240

gagaggtact tctgcccgaa cacgcgctgc tccatcacgt ggttcctctc gtggagccca      300

tgcggcgagt gctccagggc gatcacggag ttcctcagcc gctacccgca cgtgaccctg      360

ttcatctaca tcgctaggct ctaccaccac gcggacccca ggaacaggca gggcctcagg      420

gacctgatct ccagcggcgt cacgatccag atcatgaccg agcaggagtc cggctactgc      480

tggaggaact tcgtgaacta ctccccgagc aacgaggccc actggccccg ctacccgcac      540

ctctgggtcc gcctctacgt gctcgagctg tactgcatca tcctcggcct gccgccctgc      600

ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct tcaccatcgc cctgcagagc      660

tgccactacc agaggctccc gccccacatc ctgtgggcga ccgggctcaa ggggggcggg      720

ggctcaggcg ggggcgggag cggcggcggg ggctctgggg gcggcggcag cggcgggggc      780

ggcagcgggg gcggcgggtc gatgagcaag ctggagaagt tcacgaactg ctactccctc      840

agcaagaccc tgaggttcaa ggcgatcccg gtcggcaaga cccaggagaa catcgacaac      900

aagcggctgc tggtggagga cgagaagagg gctgaggact acaagggcgt gaagaagctc      960

ctggaccgct actacctgtc cttcatcaac gacgtgctcc acagcatcaa gctcaagaac     1020

ctgaacaact acatcagcct cttcaggaag aagacgcgca ccgagaagga gaacaaggag     1080

ctcgagaacc tggagatcaa cctgaggaag gagatcgcca aggcgttcaa gggcaacgag     1140

ggctacaagt ccctcttcaa gaaggacatc atcgagacga tcctcccgga gttcctggac     1200

gacaaggacg agatcgccct ggtcaactcc ttcaacggct tcaccacggc gttcaccggc     1260

ttcttcgaca accgcgagaa catgttcagc gaggaggcca agtccacgag catcgcgttc     1320

aggtgcatca acgagaacct cacccgctac atctccaaca tggacatctt cgagaaggtc     1380

gacgcgatct tcgacaagca cgaggtgcag gagatcaagg agaagatcct gaacagcgac     1440

tacgacgtcg aggacttctt cgagggcgag ttcttcaact tcgtcctcac gcaggagggc     1500

atcgacgtgt acaacgccat catcggtggc ttcgtgaccg agtccggcga gaagatcaag     1560

ggcctgaacg agtacatcaa cctctacaac cagaagacca agcagaagct gccgaagttc     1620

aagcccctgt acaagcaggt gctctccgac agggagtccc tcagcttcta cggcgagggc     1680

tacacgagcg acgaggaggt cctggaggtg ttccgcaaca ccctcaacaa gaacagcgag     1740

atcttctcca gcatcaagaa gctcgagaag ctgttcaaga acttcgacga gtactccagc     1800

gccggcatct tcgtcaagaa cggcccggcg atctccacga tcagcaagga catcttcggc     1860

gagtggaacg tgatccgcga caagtggaac gccgagtacg acgacatcca cctcaagaag     1920

aaggcggtgg tcaccgagaa gtacgaggac gacaggcgca agtccttcaa gaagatcggc     1980

tccttcagcc tcgagcagct gcaggagtac gccgacgcgg acctgagcgt ggtcgagaag     2040

ctcaaggaga tcatcatcca gaaggtcgac gagatctaca aggtgtacgg ctccagcgag     2100

aagctcttcg acgcggactt cgtcctcgag aagtccctga agaagaacga cgccgtggtc     2160

gcgatcatga aggacctcct ggactccgtg aagagcttcg agaattacat caaggccttc     2220

ttcggcgagg gcaaggagac gaacagggac gagtccttct acggcgactt cgtcctggcc     2280

tacgacatcc tcctgaaggt ggaccacatc tacgacgcga tccgcaacta cgtgacccag     2340

aagccgtaca gcaaggacaa gttcaagctc tacttccaga acccccagtt catgggcggc     2400

tgggacaagg acaaggagac ggactacagg gcgaccatcc tgcgctacgg cagcaagtac     2460

tacctcgcca tcatggacaa gaagtacgcg aagtgcctgc agaagatcga caaggacgac     2520

gtcaacggca actacgagaa gatcaactac aagctcctgc cgggccccaa caagatgctc     2580

ccgaaggtgt tcttctccaa gaagtggatg gcctactaca accccagcga ggacatccag     2640

aagatctaca agaacggcac gttcaagaag ggcgacatgt tcaacctgaa cgactgccac     2700

aagctcatcg acttcttcaa ggactccatc agccgctacc cgaagtggtc caacgcctac     2760

gacttcaact tcagcgagac cgagaagtac aaggacatcg cgggcttcta ccgcgaggtc     2820

gaggagcagg gctacaaggt gtccttcgag tccgccagca agaaggaggt cgacaagctg     2880

gtggaggagg gcaagctcta catgttccag atctacaaca aggacttctc cgacaagagc     2940

cacggcacgc ccaacctgca caccatgtac ttcaagctcc tgttcgacga gaacaaccac     3000

ggccagatca ggctgtccgg cggcgccgag ctcttcatga ggagggcgag cctgaagaag     3060

gaggagctgg tggtccaccc cgctaacagc ccaatcgcga acaagaaccc ggacaacccc     3120

aagaagacca cgaccctgtc ctacgacgtg tacaaggaca agaggttcag cgaggaccag     3180

tacgagctcc acatcccgat cgcgatcaac aagtgcccca agaacatctt caagatcaac     3240

accgaggtcc gcgtgctcct gaagcacgac gacaacccct acgtgatcgg catcgctagg     3300

ggcgagagga acctcctgta catcgtggtc gtggacggca agggcaacat cgtggagcag     3360

tactccctca acgagatcat caacaacttc aacggcatca ggatcaagac ggactaccac     3420

agcctcctgg acaagaagga gaaggagagg ttcgaggccc gccagaactg gacctccatc     3480

gagaacatca aggagctgaa ggcgggctac atcagccagg tcgtgcacaa gatctgcgag     3540

ctcgtcgaga agtacgacgc cgtgatcgcc ctcgcggacc tgaactccgg cttcaagaac     3600

agccgcgtca aggtggagaa gcaggtctac cagaagttcg agaagatgct catcgacaag     3660

ctgaactaca tggtggacaa gaagtccaac ccctgcgcta cgggcggcgc gctgaagggc     3720

taccagatca ccaacaagtt cgagagcttc aagtccatga gcactcagaa cggcttcatc     3780

ttctacatcc cggcgtggct cacgtccaag atcgacccca gcaccggctt cgtcaacctc     3840

ctgaagacga agtacacctc catcgccgac agcaagaagt tcatctccag cttcgaccgc     3900

atcatgtatg tgccggagga ggacctgttc gagttcgccc tcgactacaa gaacttctcc     3960

cgcacggacg cggactacat caagaagtgg aagctgtaca gctacggcaa ccgcatccgc     4020

atcttcagga accccaagaa gaacaacgtc ttcgactggg aggaggtgtg cctgacctcc     4080

gcgtacaagg agctcttcaa caagtacggc atcaactacc agcagggcga catcagggct     4140

ctcctgtgcg agcagagcga caaggccttc tactccagct tcatggcgct gatgtccctc     4200

atgctgcaga tgaggaactc gatcaccggc aggacggacg tggccttcct catctccccg     4260

gtgaagaaca gcgacggcat cttctacgac tccaggaact acgaggccca ggagaacgcg     4320

atcctcccaa agaacgcgga cgccaacggc gcctacaaca tcgccaggaa ggtcctctgg     4380

gctatcggcc agttcaagaa ggcggaggac gagaagctgg acaaggtgaa gatcgccatc     4440

agcaacaagg agtggctcga gtacgcccag acctcggtca agcacggcag cccgaagaag     4500

aagcgcaagg tgtccggcgg cagcacgaac ctgtccgaca tcatcgagaa ggagaccggc     4560

aagcagctcg tgatccagga gagcatcctc atgctgccgg aggaggtcga ggaggtcatc     4620

ggcaacaagc ccgagtccga catcctcgtc cacacggcct acgacgagtc caccgacgag     4680

aacgtgatgc tcctgacctc ggacgctccc gagtacaagc catgggccct ggtcatccag     4740

gacagcaacg gcgagaacaa gatcaagatg ctctccggcg gcagcccgaa gaagaagcgc     4800

aaagtgtga                                                             4809


<210>  24
<211>  1602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Protein

<400>  24

Met Pro Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val 
1               5                   10                  15      


Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu 
            20                  25                  30          


Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr 
        35                  40                  45              


Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln 
    50                  55                  60                  


Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr 
65                  70                  75                  80  


Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu 
                85                  90                  95      


Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu 
            100                 105                 110         


Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr 
        115                 120                 125             


His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser 
    130                 135                 140                 


Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys 
145                 150                 155                 160 


Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro 
                165                 170                 175     


Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys 
            180                 185                 190         


Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln 
        195                 200                 205             


Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln 
    210                 215                 220                 


Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Lys Leu Glu 
            260                 265                 270         


Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala 
        275                 280                 285             


Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu 
    290                 295                 300                 


Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu 
305                 310                 315                 320 


Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile 
                325                 330                 335     


Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr 
            340                 345                 350         


Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu 
        355                 360                 365             


Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser 
    370                 375                 380                 


Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp 
385                 390                 395                 400 


Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr 
                405                 410                 415     


Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu 
            420                 425                 430         


Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr 
        435                 440                 445             


Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe 
    450                 455                 460                 


Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp 
465                 470                 475                 480 


Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu 
                485                 490                 495     


Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val 
            500                 505                 510         


Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu 
        515                 520                 525             


Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr 
    530                 535                 540                 


Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly 
545                 550                 555                 560 


Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn 
                565                 570                 575     


Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe 
            580                 585                 590         


Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly 
        595                 600                 605             


Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val 
    610                 615                 620                 


Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys 
625                 630                 635                 640 


Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe 
                645                 650                 655     


Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp 
            660                 665                 670         


Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys 
        675                 680                 685             


Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp 
    690                 695                 700                 


Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val 
705                 710                 715                 720 


Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr 
                725                 730                 735     


Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser 
            740                 745                 750         


Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp 
        755                 760                 765             


His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser 
    770                 775                 780                 


Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly 
785                 790                 795                 800 


Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr 
                805                 810                 815     


Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys 
            820                 825                 830         


Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile 
        835                 840                 845             


Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe 
    850                 855                 860                 


Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln 
865                 870                 875                 880 


Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu 
                885                 890                 895     


Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg 
            900                 905                 910         


Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu 
        915                 920                 925             


Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly 
    930                 935                 940                 


Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu 
945                 950                 955                 960 


Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe 
                965                 970                 975     


Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys 
            980                 985                 990         


Leu Leu Phe Asp Glu Asn Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly 
        995                 1000                 1005             


Ala Glu  Leu Phe Met Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu 
    1010                 1015                 1020             


Val Val  His Pro Ala Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp 
    1025                 1030                 1035             


Asn Pro  Lys Lys Thr Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp 
    1040                 1045                 1050             


Lys Arg  Phe Ser Glu Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala 
    1055                 1060                 1065             


Ile Asn  Lys Cys Pro Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val 
    1070                 1075                 1080             


Arg Val  Leu Leu Lys His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile 
    1085                 1090                 1095             


Ala Arg  Gly Glu Arg Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly 
    1100                 1105                 1110             


Lys Gly  Asn Ile Val Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn 
    1115                 1120                 1125             


Asn Phe  Asn Gly Ile Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu 
    1130                 1135                 1140             


Asp Lys  Lys Glu Lys Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr 
    1145                 1150                 1155             


Ser Ile  Glu Asn Ile Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln 
    1160                 1165                 1170             


Val Val  His Lys Ile Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val 
    1175                 1180                 1185             


Ile Ala  Leu Ala Asp Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val 
    1190                 1195                 1200             


Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile 
    1205                 1210                 1215             


Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala 
    1220                 1225                 1230             


Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu 
    1235                 1240                 1245             


Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile 
    1250                 1255                 1260             


Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val 
    1265                 1270                 1275             


Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys 
    1280                 1285                 1290             


Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp 
    1295                 1300                 1305             


Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp 
    1310                 1315                 1320             


Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg 
    1325                 1330                 1335             


Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp 
    1340                 1345                 1350             


Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys 
    1355                 1360                 1365             


Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys 
    1370                 1375                 1380             


Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met 
    1385                 1390                 1395             


Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile Thr Gly  Arg Thr Asp 
    1400                 1405                 1410             


Val Ala  Phe Leu Ile Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe 
    1415                 1420                 1425             


Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro 
    1430                 1435                 1440             


Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val 
    1445                 1450                 1455             


Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu 
    1460                 1465                 1470             


Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr 
    1475                 1480                 1485             


Ala Gln  Thr Ser Val Lys His  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1490                 1495                 1500             


Val Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1505                 1510                 1515             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1520                 1525                 1530             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1535                 1540                 1545             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1550                 1555                 1560             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1565                 1570                 1575             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1580                 1585                 1590             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1595                 1600         


<210>  25
<211>  1802
<212>  DNA
<213>  Saccharum officinarum

<400>  25
gaattcatta tgtggtctag gtaggttcta tatataagaa aacttgaaat gttctaaaaa       60

aaaattcaag cccatgcatg attgaagcaa acggtatagc aacggtgtta acctgatcta      120

gtgatctctt gcaatcctta acggccacct accgcaggta gcaaacggcg tccccctcct      180

cgatatctcc gcggcgacct ctggcttttt ccgcggaatt gcgcggtggg gacggattcc      240

acgagaccgc gacgcaaccg cctctcgccg ctgggcccca caccgctcgg tgccgtagcc      300

tcacgggact ctttctccct cctcccccgt tataaattgg cttcatcccc tccttgcctc      360

atccatccaa atcccagtcc ccaatcccat cccttcgtag gagaaattca tcgaagctaa      420

gcgaatcctc gcgatcctct caaggtactg cgagttttcg atccccctct cgacccctcg      480

tatgtttgtg tttgtcgtag cgtttgatta ggtatgcttt ccctgtttgt gttcgtcgta      540

gcgtttgatt aggtatgctt tccctgttcg tgttcatcgt agtgtttgat taggtcgtgt      600

gaggcgatgg cctgctcgcg tccttcgatc tgtagtcgat ttgcgggtcg tggtgtagat      660

ctgcgggctg tgatgaagtt atttggtgtg atctgctcgc ctgattctgc gggttggctc      720

gagtagatat gatggttgga ccggttggtt cgtttaccgc gctagggttg ggctgggatg      780

atgttgcatg cgccgttgcg cgtgatcccg cagcaggact tgcgtttgat tgccagatct      840

cgttacgatt atgtgatttg gtttggactt tttagatctg tagcttctgc ttatgtgcca      900

gatgcgccta ctgctcatat gcctgatgat aatcataaat ggctgtggaa ctaactagtt      960

gattgcggag tcatgtatca gctacaggtg tagggactag ctacaggtgt agggacttgc     1020

gtctaattgt ttggtccttt actcatgttg caattatgca atttagttta gattgtttgt     1080

tccactcatc taggctgtaa aagggacact gcttagattg ctgtttaatc tttttagtag     1140

attatattat attggtaact tattacccct attacatgcc atacgtgact tctgctcatg     1200

cctgatgata atcatagatc actgtggaat taattagttg attgttgaat catgtttcat     1260

gtacatacca cggcacaatt gcttagttcc ttaacaaatg caaattttac tgatccatgt     1320

atgatttgcg tggttctcta atgtgaaata ctatagctac ttgttagtaa gaatcaggtt     1380

cgtatgctta atgctgtatg tgccttctgc tcatgcctga tgataatcat atatcactgg     1440

aattaattag ttgatcgttt aatcatatat caagtacata ccatgccaca atttttagtc     1500

acttaaccca tgcagattga actggtccct gcatgttttg ctaaattgtt ctattctgat     1560

tagaccatat atcatgtatt tttttttggt aatggttctc ttattttaaa tgctatatag     1620

ttctggtact tgttagaaag atctgcttca tagtttagtt gcctatccct cgaattagga     1680

tgctgagcag ctgatcctat agctttgttt catgtatcaa ttcttttgtg ttcaacagtc     1740

agtttttgtt agattcattg taacttatgg tcgcttactc ttctggtcct caatgcttgc     1800

ag                                                                    1802


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26
gggaaagacc gaggagaaga tct                                               23


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
aagaccgagg agaagatcta                                                   20


<210>  28
<211>  90
<212>  DNA
<213>  Zea mays

<400>  28
gtttggggaa agaccgagga gaagatctac gggcctgtcg ctggaacgga ctacagggac       60

aaccagctgc ggttcagcct gctatgccag                                        90


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
agatgggaga cgggtacgag acgg                                              24


<210>  30
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  30
gtatgggttg ttgttgaggc tcagg                                             25


<210>  31
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  31
gaccacccac tgttcctgga gaggg                                             25


