                         б

<110>  ݿƼ޹˾
 
<120>  һֵ弰ṹǶϿԭ

<130>  0141-PA-011

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  128
<212>  PRT
<213>  Vicugna pacos

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Gly Gly Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Cys Glu Gly Ala Gly Asp Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Asp 
        115                 120                 125             


<210>  2
<211>  129
<212>  PRT
<213>  Vicugna pacos

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Glu Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Gly Gly Gly Ile Pro Tyr Tyr Arg Thr Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Gln Asn Thr Val Ala Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Ala Arg Ala Val Met Thr Val Thr Pro Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125             


Asp 
    


<210>  3
<211>  128
<212>  PRT
<213>  Vicugna pacos

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Leu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Asn Asp Asp Thr Thr Tyr Tyr Thr Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Glu Asn Phe Glu Met Pro Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Asp 
        115                 120                 125             


<210>  4
<211>  128
<212>  PRT
<213>  Vicugna pacos

<400>  4

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Gly Ser Ile Met Trp Pro Thr Gly Thr Pro Leu Tyr Lys Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Val Gly Ala Ser Gly Tyr Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Asp 
        115                 120                 125             


<210>  5
<211>  127
<212>  PRT
<213>  Vicugna pacos

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Ser Ile Val Ser Ile Asp 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Asn Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Gln Trp Ser Ser Val Asp Phe Ala Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Asp 
        115                 120                 125         


<210>  6
<211>  137
<212>  PRT
<213>  Vicugna pacos

<400>  6

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ile Gly Gly Leu Pro Tyr Tyr Ala Val Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Asp Cys Ser Gly Tyr Val Cys Tyr Asp Lys Glu Pro Leu 
            100                 105                 110         


Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Glu Pro Lys Thr Pro Lys Pro Gln Asp 
    130                 135         


<210>  7
<211>  351
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-4

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Gly Gly Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Cys Glu Gly Ala Gly Asp Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Asp 
        115                 120                 125             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    130                 135                 140                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
145                 150                 155                 160 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                165                 170                 175     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            180                 185                 190         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
225                 230                 235                 240 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                245                 250                 255     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            260                 265                 270         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        275                 280                 285             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    290                 295                 300                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
305                 310                 315                 320 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                325                 330                 335     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 350     


<210>  8
<211>  352
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-15

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Glu Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Gly Gly Gly Ile Pro Tyr Tyr Arg Thr Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Gln Asn Thr Val Ala Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Ala Arg Ala Val Met Thr Val Thr Pro Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln 
        115                 120                 125             


Asp Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    130                 135                 140                 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
145                 150                 155                 160 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
                165                 170                 175     


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
            180                 185                 190         


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        195                 200                 205             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    210                 215                 220                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235                 240 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
                245                 250                 255     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            260                 265                 270         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        275                 280                 285             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    290                 295                 300                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
305                 310                 315                 320 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                325                 330                 335     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 350         


<210>  9
<211>  351
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-20

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Leu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Asn Asp Asp Thr Thr Tyr Tyr Thr Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Glu Asn Phe Glu Met Pro Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Asp 
        115                 120                 125             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    130                 135                 140                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
145                 150                 155                 160 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                165                 170                 175     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            180                 185                 190         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
225                 230                 235                 240 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                245                 250                 255     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            260                 265                 270         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        275                 280                 285             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    290                 295                 300                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
305                 310                 315                 320 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                325                 330                 335     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 350     


<210>  10
<211>  351
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-52

<400>  10

Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Gly Ser Ile Met Trp Pro Thr Gly Thr Pro Leu Tyr Lys Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Val Gly Ala Ser Gly Tyr Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Asp 
        115                 120                 125             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    130                 135                 140                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
145                 150                 155                 160 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                165                 170                 175     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            180                 185                 190         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
225                 230                 235                 240 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                245                 250                 255     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            260                 265                 270         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        275                 280                 285             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    290                 295                 300                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
305                 310                 315                 320 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                325                 330                 335     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 350     


<210>  11
<211>  350
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-19B

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Ser Ile Val Ser Ile Asp 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Thr Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Asn Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Gln Trp Ser Ser Val Asp Phe Ala Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Asp Thr 
        115                 120                 125             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    130                 135                 140                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
145                 150                 155                 160 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                165                 170                 175     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            180                 185                 190         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        195                 200                 205             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    210                 215                 220                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
225                 230                 235                 240 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                245                 250                 255     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            260                 265                 270         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        275                 280                 285             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    290                 295                 300                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
305                 310                 315                 320 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                325                 330                 335     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 350 


<210>  12
<211>  360
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-35B

<400>  12

Glu Val Gln Val Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ile Gly Gly Leu Pro Tyr Tyr Ala Val Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Asp Cys Ser Gly Tyr Val Cys Tyr Asp Lys Glu Pro Leu 
            100                 105                 110         


Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


Glu Pro Lys Thr Pro Lys Pro Gln Asp Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
        195                 200                 205             


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    210                 215                 220                 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
225                 230                 235                 240 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                245                 250                 255     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            260                 265                 270         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        275                 280                 285             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    290                 295                 300                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
305                 310                 315                 320 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                325                 330                 335     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            340                 345                 350         


His Met Gln Ala Leu Pro Pro Arg 
        355                 360 


<210>  13
<211>  357
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-J22.9

<400>  13

Asp Ile Val Met Thr Gln Ser Gln Arg Phe Met Thr Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Ser Val Asp Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Arg Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Phe Ser Ala Ser Leu Arg Phe Ser Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Ile Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg 
145                 150                 155                 160 


Arg Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asp 
                165                 170                 175     


Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys Asp Lys Phe Ile Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Lys Val 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp 
    210                 215                 220                 


Tyr Gly Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        275                 280                 285             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    290                 295                 300                 


Leu Val Ile Thr Leu Tyr Cys Arg Phe Ser Val Val Lys Arg Gly Arg 
305                 310                 315                 320 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                325                 330                 335     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            340                 345                 350         


Glu Gly Gly Cys Glu 
        355         


<210>  14
<211>  1116
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-4

<400>  14
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctcgtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgtg cagcctctgg attcactttg gattattatg ccataggctg gttccgccag      180

gccccaggga aggagcgcga gggggtctca tgtattggtg gtagtgatgg tagcacatac      240

tatgcagact ccgtgaaggg ccgattcacc atctccagag acaatgccaa gaacacggtg      300

tatctgcaaa tgaacagcct gaaacctgag gacacggccg tttattactg tgcgacagca      360

tgtgaagggg ctggtgatgg tgactactgg ggccagggga cccaggtcac cgtctcctca      420

gaacccaaga caccaaaacc acaagacacc acgacgccag cgccgcgacc accaacaccg      480

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      540

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      600

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg      660

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact      720

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg      780

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      840

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      900

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      960

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1020

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1080

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1116


<210>  15
<211>  1119
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-15

<400>  15
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctcgtgga gtctggggga ggattggtgc aggctggggg ctcgctcaga      120

ctctcctgcg cagcctctgg acttaccttc agtgaatata ccatgggctg gttccgccag      180

cctccaggga aggagcgtga atttgtagcg gctattagtg gaggtggtat cccatactat      240

agaaccaccg tgaagggtcg attctccatc tccagagaca acgcccagaa cacggtcgct      300

ctggagatga acagcctgaa acctgaggac acggccgttt attactgtgc agcagatgcg      360

cgtgcggtga tgactgtgac tcccaactac tggggccagg ggacccaggt caccgtctcc      420

tcagaaccca agacaccaaa accacaagac accacgacgc cagcgccgcg accaccaaca      480

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      540

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      600

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaaa      660

cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact      720

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa      780

ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag      840

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      900

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac      960

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag     1020

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac     1080

acctacgacg cccttcacat gcaggccctg ccccctcgc                            1119


<210>  16
<211>  1116
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-20

<400>  16
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctcgtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcaccttc aatctgtatg ccatgggctg gttccgccag      180

actccaggga aggagcgtga aattgtagca gctattggct ggaatgatga caccacatac      240

tatacaggct ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacagtg      300

tatctgcaaa tgaacagtct gaaacctgag gacacggccg tttattactg tgcagcggat      360

gagaattttg agatgcccta tgactactgg ggccagggga cccaggtcac cgtctcctca      420

gaacccaaga caccaaaacc acaagacacc acgacgccag cgccgcgacc accaacaccg      480

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      540

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      600

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg      660

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact      720

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg      780

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      840

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      900

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      960

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1020

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1080

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1116


<210>  17
<211>  1116
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-52

<400>  17
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcagttgc agctcgtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcaccttt agtgactatg tcatggcctg gttccgccag      180

gctcccggga aggatcgtga gtttgtagga tctattatgt ggcctaccgg taccccattg      240

tataaagact ccgtgaaggg ccgattcgcc atctccagag acaacgccaa gaagacgctg      300

tatctacaaa tgaacagtct gaaacctgag gacacggccg tgtattactg tgcggcggct      360

cgggttgggg caagtggata tgagtattgg ggccagggga cccaggtcac cgtctcctca      420

gaacccaaga caccaaaacc acaagacacc acgacgccag cgccgcgacc accaacaccg      480

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      540

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      600

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg      660

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact      720

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg      780

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      840

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      900

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      960

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1020

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1080

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1116


<210>  18
<211>  1113
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-19B

<400>  18
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgcaggtgc agctcgtgga gtctggggga ggcttggtgc agcctggggg gtctctgaga      120

ctctcctgta aagcctctgg aagcatcgtc agtatcgatt acatgggctg gtaccgccag      180

actccaggga agcagcgcga gttggtcgca ggtattaaca gtggtggtag tacatattat      240

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgttt      300

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc tgctaggcag      360

tggagctcag ttgactttgc ttcctggggc caggggaccc aggtcaccgt ctcctcggaa      420

cccaagacac caaaaccaca agacaccacg acgccagcgc cgcgaccacc aacaccggcg      480

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg      540

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg      600

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc      660

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa      720

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga      780

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat      840

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg      900

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa      960

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1020

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1080

gacgcccttc acatgcaggc cctgccccct cgc                                  1113


<210>  19
<211>  1143
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-35B

<400>  19
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc aggtggtgga gtctggggga ggattggtgc aggctggggg ctctctgaga      120

ctctcctgtg cagcctctgg acgcaccttc agtagctatg ccatgggctg gttccgccag      180

gctccaggga aggagcgtga gtttgtagca gctattagct ggattggtgg tctgccatac      240

tatgcagtct ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacgctg      300

tatctgcaaa tgaacagcct gaaatctgag gacacggccg tgtattactg tgcggctcac      360

gactgttcag gctatgtgtg ttatgacaag gagcccctat atgagtatga ctactggggc      420

caggggaccc aggtcaccgt ctcctcagaa cccaagacac caaaaccaca agacaccacg      480

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      540

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      600

gcctgtgata tctacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca      660

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa      720

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca      780

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc      840

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag      900

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg      960

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1020

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1080

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1140

cgc                                                                   1143


<210>  20
<211>  1134
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-J22.9

<400>  20
atggctctgc ctgtgaccgc cctgctgctg cctctggctc tgctgctgca cgccgctcgg       60

cctgatatag tgatgactca aagtcaaaga tttatgacca catctgtcgg agatcgggtc      120

tctgtgacct gtaaggcatc ccagagtgtt gactccaacg tagcctggta ccagcagaaa      180

ccgcgacagt ctcccaaggc attgatattt tcagctagtc tgaggttttc aggtgtacct      240

gctcggttca ccgggtctgg tagcggaaca gacttcactt tgacaattag taatcttcaa      300

agtgaagacc ttgcggaata cttctgtcag cagtacaaca attatcccct tacctttggg      360

gcaggaacaa agcttgaatt gaagggcggc gggggttctg gtggcggcgg cagcggcggt      420

ggaggatcac aggtacagct tcagcagagc gggggaggtt tggtacaacc tggcggatct      480

ttgaaacttt cctgtgcagc ttcaggaata gacttttcac ggtactggat gagctgggtc      540

cgccgagcac ctgggaaagg tcttgaatgg attggggaga taaatccaga ttcttccaca      600

attaactatg ctcccagttt gaaggacaag ttcatcatta gccgcgataa cgctaaaaac      660

actttgtact tgcagatgag taaagtacgg agtgaggata cagcgttgta ctactgcgcg      720

agcttgtatt atgattacgg agatgccatg gattactggg gccaaggcac gtctgtgact      780

gtatcttcta ctacaactcc agcacccaga ccccctacac ctgctccaac tatcgcaagt      840

cagcccctgt cactgcgccc tgaagcctgt cgccctgctg ccgggggagc tgtgcatact      900

cggggactgg actttgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaggt tcagtgtcgt gaagagaggc     1020

cggaagaagc tgctgtacat cttcaagcag cctttcatga ggcccgtgca gactacccag     1080

gaggaagatg gatgcagctg tagattccct gaagaggagg aaggaggctg tgag           1134


<210>  21
<211>  21
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Lenti-For

<400>  21
tcaagcctca gacagtggtt c                                                 21


<210>  22
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  Lenti-Rev

<400>  22
cctcataaag agacagcaac cagg                                              24


<210>  23
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-4 CDR1

<400>  23

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-4 CDR2

<400>  24

Ile Gly Gly Ser Asp Gly Ser Thr 
1               5               


<210>  25
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-4 CDR3

<400>  25

Ala Thr Ala Cys Glu Gly Ala Gly Asp Gly Asp Tyr 
1               5                   10          


<210>  26
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-15 CDR1

<400>  26

Gly Leu Thr Phe Ser Glu Tyr Thr 
1               5               


<210>  27
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-15 CDR2

<400>  27

Ile Ser Gly Gly Gly Ile Pro 
1               5           


<210>  28
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-15 CDR3

<400>  28

Ala Ala Asp Ala Arg Ala Val Met Thr Val Thr Pro Asn Tyr 
1               5                   10                  


<210>  29
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-20 CDR1

<400>  29

Gly Arg Thr Phe Asn Leu Tyr Ala 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-20 CDR2

<400>  30

Ile Gly Trp Asn Asp Asp Thr Thr 
1               5               


<210>  31
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-20 CDR3

<400>  31

Ala Ala Asp Glu Asn Phe Glu Met Pro Tyr Asp Tyr 
1               5                   10          


<210>  32
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-52 CDR1

<400>  32

Gly Arg Thr Phe Ser Asp Tyr Val 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-52 CDR2

<400>  33

Ile Met Trp Pro Thr Gly Thr Pro 
1               5               


<210>  34
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-52 CDR3

<400>  34

Ala Ala Ala Arg Val Gly Ala Ser Gly Tyr Glu Tyr 
1               5                   10          


<210>  35
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-19B CDR1

<400>  35

Gly Ser Ile Val Ser Ile Asp Tyr 
1               5               


<210>  36
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-19B CDR2

<400>  36

Ile Asn Ser Gly Gly Ser Thr 
1               5           


<210>  37
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-19B CDR3

<400>  37

Ala Ala Arg Gln Trp Ser Ser Val Asp Phe Ala Ser 
1               5                   10          


<210>  38
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-35B CDR1

<400>  38

Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-35B CDR2

<400>  39

Ile Ser Trp Ile Gly Gly Leu Pro 
1               5               


<210>  40
<211>  21
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-35B CDR3

<400>  40

Ala Ala His Asp Cys Ser Gly Tyr Val Cys Tyr Asp Lys Glu Pro Leu 
1               5                   10                  15      


Tyr Glu Tyr Asp Tyr 
            20      


<210>  41
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-4-2

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Gly Gly Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Cys Glu Gly Ala Gly Asp Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  42
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-15-2

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Glu Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Ile Pro Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Ala Arg Ala Val Met Thr Val Thr Pro Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  43
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-20-2

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Leu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Gly Leu Glu Ile Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Asn Asp Asp Thr Thr Tyr Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Glu Asn Phe Glu Met Pro Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  44
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-52-2

<400>  44

Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Gly Ser Ile Met Trp Pro Thr Gly Thr Pro Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Val Gly Ala Ser Gly Tyr Glu Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  45
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-19B-2

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Val Ser Ile Asp 
            20                  25                  30          


Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Asn Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Gln Trp Ser Ser Val Asp Phe Ala Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  46
<211>  128
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-35B-2

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Ile Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Asp Cys Ser Gly Tyr Val Cys Tyr Asp Lys Glu Pro Leu 
            100                 105                 110         


Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  47
<211>  357
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-4-2

<400>  47
gaggtgcagc tggtggagag cggcggcgga ctggtgcagc ctggaggaag cctgaggctg       60

agctgtgccg cctccggctt caccctggat tactatgcta tgggctggtt caggcaggct      120

cccggcaagg agcgggaggg agtgtcctgc atcggcggct ccgacggcag cacctattat      180

gccgacagcg tgaagggccg gttcaccatc tccagggata atgctaagaa caccctgtac      240

ctgcagatga attccctgag ggctgaggac accgccgtgt attactgtgc taccgcctgc      300

gagggcgccg gcgatggaga ttactggggc cagggcaccc tggtgaccgt gtccagc         357


<210>  48
<211>  360
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-15-2

<400>  48
gaggtgcagc tggtggagtc cggcggcgga ctggtgcagc ctggaggaag cctgcggctg       60

agctgtgccg cctccggact gaccttctcc gagtatacaa tgggttggtt ccggcaggcc      120

cccggcaagg agagggagtt cgtgtccgcc atcagcggcg gcggcatccc ttactacgcc      180

gactccgtga agggccggtt caccatcagc cgggacaacg ctaagaacac cctgtacctg      240

cagatgaact ccctgcgggc cgaggatacc gctgtgtatt attgtgctgc tgacgctcgg      300

gctgtgatga ccgtgacccc taattattgg ggccagggca ccctggtgac cgtgtccagc      360


<210>  49
<211>  357
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-20-2

<400>  49
gaggtgcagc tggtggagag cggcggcgga ctggtgcagc caggaggaag cctgcggctg       60

agctgtgctg ccagcggcag gaccttcaac ctgtacgcta tgggttggtt caggcagacc      120

cccggcaagg gcctggagat cgtggccgct atcggctgga acgatgatac cacctattac      180

gccggctccg tgaagggccg gttcaccatc tcccgggata acgctaagaa caccctgtat      240

ctgcagatga actccctgcg ggctgaggac accgctgtgt attactgtgc cgccgacgag      300

aacttcgaga tgccttatga ctattggggc cagggcaccc tggtgaccgt gagcagc         357


<210>  50
<211>  357
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-52-2

<400>  50
gagctgcagc tggtggagag cggcggcgga ctggtgcagc caggaggaag cctgaggctg       60

agctgtgccg ccagcggcag aaccttcagc gactatgtga tggcctgggt gcggcaggct      120

cctggcaagg gactggagtt cgtgggcagc atcatgtggc ccaccggcac ccccctgtac      180

gccgattccg tgaagggccg gttcgctatc agccgggaca actccaagaa gaccctgtat      240

ctgcagatga acagcctgag ggctgaggac accgccgtgt attattgcgc tgctgcccgg      300

gtgggcgcca gcggatatga gtactggggc cagggcaccc tggtgaccgt gtccagc         357


<210>  51
<211>  354
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-19B-2

<400>  51
gaggtgcagc tggtggagag cggcggcgga ctggtgcagc caggaggaag cctgcggctg       60

tcctgtgctg cctccggctc catcgtgtcc atcgactata tgggctggta ccggcaggcc      120

cccggcaagc agagggagtt ggtggctggc atcaactccg gcggctccac ctattacgct      180

gatagcgtga agggccggtt caccatctcc cgggacaatg ctaagaacac cctgtacctg      240

cagatgaatt ccctgcgggc cgaggatacc gctgtgtact attgtgctgc ccggcagtgg      300

tccagcgtgg acttcgcctc ctggggccag ggcaccctgg tgacagtgtc ctcc            354


<210>  52
<211>  384
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  sdAb hu-35B-2

<400>  52
gaggtgcagc tggtggagtc cggcggcgga ctggtgcagc caggaggaag cctgaggctg       60

agctgtgccg cttccggcag gaccttcagc agctacgcta tgggttggtt caggcaggcc      120

cccggcaagg agagggagtt cgtgtccgcc atctcctgga tcggcggcct gacctactac      180

gccgactccg tgaagggcag gttcaccatc agcagggaca atgctaagaa caccctgtat      240

ctgcagatga attccctgag ggctgaggac accgctgtgt actactgtgc tgctcacgat      300

tgttccggct atgtgtgtta tgataaggag cccctgtacg agtatgacta ctggggccag      360

ggcaccctgg tgaccgtgag cagc                                             384


<210>  53
<211>  363
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-4-2

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Leu Asp Tyr Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Gly Val Ser Cys Ile Gly Gly Ser Asp Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Thr Ala Cys Glu Gly Ala Gly Asp Gly Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro 
    130                 135                 140                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
145                 150                 155                 160 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                165                 170                 175     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
            180                 185                 190         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        195                 200                 205             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    210                 215                 220                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
225                 230                 235                 240 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                245                 250                 255     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            260                 265                 270         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        275                 280                 285             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    290                 295                 300                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                325                 330                 335     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            340                 345                 350         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360             


<210>  54
<211>  364
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-15-2

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu 
        35                  40                  45              


Thr Phe Ser Glu Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ser Ala Ile Ser Gly Gly Gly Ile Pro Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Asp Ala Arg Ala Val Met Thr Val Thr Pro 
        115                 120                 125             


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr 
    130                 135                 140                 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
145                 150                 155                 160 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
                165                 170                 175     


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
            180                 185                 190         


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
        195                 200                 205             


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
    210                 215                 220                 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
225                 230                 235                 240 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
                245                 250                 255     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
            260                 265                 270         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        275                 280                 285             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    290                 295                 300                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
305                 310                 315                 320 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                325                 330                 335     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            340                 345                 350         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 


<210>  55
<211>  363
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-20-2

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
        35                  40                  45              


Thr Phe Asn Leu Tyr Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Ile Val Ala Ala Ile Gly Trp Asn Asp Asp Thr Thr Tyr 
65                  70                  75                  80  


Tyr Ala Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Asp Glu Asn Phe Glu Met Pro Tyr Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro 
    130                 135                 140                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
145                 150                 155                 160 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                165                 170                 175     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
            180                 185                 190         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        195                 200                 205             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    210                 215                 220                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
225                 230                 235                 240 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                245                 250                 255     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            260                 265                 270         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        275                 280                 285             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    290                 295                 300                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                325                 330                 335     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            340                 345                 350         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360             


<210>  56
<211>  363
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-52-2

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
        35                  40                  45              


Thr Phe Ser Asp Tyr Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Phe Val Gly Ser Ile Met Trp Pro Thr Gly Thr Pro Leu 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Lys Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Val Gly Ala Ser Gly Tyr Glu 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro 
    130                 135                 140                 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
145                 150                 155                 160 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
                165                 170                 175     


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
            180                 185                 190         


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
        195                 200                 205             


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
    210                 215                 220                 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
225                 230                 235                 240 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
                245                 250                 255     


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
            260                 265                 270         


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
        275                 280                 285             


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
    290                 295                 300                 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
305                 310                 315                 320 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
                325                 330                 335     


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
            340                 345                 350         


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360             


<210>  57
<211>  362
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-19B-2

<400>  57

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
        35                  40                  45              


Ile Val Ser Ile Asp Tyr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gln Arg Glu Leu Val Ala Gly Ile Asn Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Ala Arg Gln Trp Ser Ser Val Asp Phe Ala Ser 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
    130                 135                 140                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
145                 150                 155                 160 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                165                 170                 175     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            180                 185                 190         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        195                 200                 205             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    210                 215                 220                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
225                 230                 235                 240 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                245                 250                 255     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            260                 265                 270         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        275                 280                 285             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    290                 295                 300                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
305                 310                 315                 320 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                325                 330                 335     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            340                 345                 350         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360         


<210>  58
<211>  372
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-35B-2

<400>  58

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ser Ala Ile Ser Trp Ile Gly Gly Leu Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ala His Asp Cys Ser Gly Tyr Val Cys Tyr 
        115                 120                 125             


Asp Lys Glu Pro Leu Tyr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
                165                 170                 175     


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
        195                 200                 205             


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            260                 265                 270         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        275                 280                 285             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    290                 295                 300                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
305                 310                 315                 320 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                325                 330                 335     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            340                 345                 350         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        355                 360                 365             


Leu Pro Pro Arg 
    370         


<210>  59
<211>  1089
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-4-2

<400>  59
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gagcggcggc ggactggtgc agcctggagg aagcctgagg      120

ctgagctgtg ccgcctccgg cttcaccctg gattactatg ctatgggctg gttcaggcag      180

gctcccggca aggagcggga gggagtgtcc tgcatcggcg gctccgacgg cagcacctat      240

tatgccgaca gcgtgaaggg ccggttcacc atctccaggg ataatgctaa gaacaccctg      300

tacctgcaga tgaattccct gagggctgag gacaccgccg tgtattactg tgctaccgcc      360

tgcgagggcg ccggcgatgg agattactgg ggccagggca ccctggtgac cgtgtccagc      420

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      480

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      540

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      600

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      660

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      720

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      780

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      840

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      900

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      960

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1020

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1080

ccccctcgc                                                             1089


<210>  60
<211>  1092
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-15-2

<400>  60
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtccggcggc ggactggtgc agcctggagg aagcctgcgg      120

ctgagctgtg ccgcctccgg actgaccttc tccgagtata caatgggttg gttccggcag      180

gcccccggca aggagaggga gttcgtgtcc gccatcagcg gcggcggcat cccttactac      240

gccgactccg tgaagggccg gttcaccatc agccgggaca acgctaagaa caccctgtac      300

ctgcagatga actccctgcg ggccgaggat accgctgtgt attattgtgc tgctgacgct      360

cgggctgtga tgaccgtgac ccctaattat tggggccagg gcaccctggt gaccgtgtcc      420

agcaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc      480

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg      540

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt      600

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata      660

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc      720

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca      780

gacgcccccg cgtacaagca gggccagaac cagctctata acgagctcaa tctaggacga      840

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag      900

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg      960

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1020

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1080

ctgccccctc gc                                                         1092


<210>  61
<211>  1089
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-20-2

<400>  61
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gagcggcggc ggactggtgc agccaggagg aagcctgcgg      120

ctgagctgtg ctgccagcgg caggaccttc aacctgtacg ctatgggttg gttcaggcag      180

acccccggca agggcctgga gatcgtggcc gctatcggct ggaacgatga taccacctat      240

tacgccggct ccgtgaaggg ccggttcacc atctcccggg ataacgctaa gaacaccctg      300

tatctgcaga tgaactccct gcgggctgag gacaccgctg tgtattactg tgccgccgac      360

gagaacttcg agatgcctta tgactattgg ggccagggca ccctggtgac cgtgagcagc      420

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      480

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      540

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      600

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      660

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      720

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      780

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      840

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      900

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      960

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1020

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1080

ccccctcgc                                                             1089


<210>  62
<211>  1089
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-52-2

<400>  62
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggagctgc agctggtgga gagcggcggc ggactggtgc agccaggagg aagcctgagg      120

ctgagctgtg ccgccagcgg cagaaccttc agcgactatg tgatggcctg ggtgcggcag      180

gctcctggca agggactgga gttcgtgggc agcatcatgt ggcccaccgg cacccccctg      240

tacgccgatt ccgtgaaggg ccggttcgct atcagccggg acaactccaa gaagaccctg      300

tatctgcaga tgaacagcct gagggctgag gacaccgccg tgtattattg cgctgctgcc      360

cgggtgggcg ccagcggata tgagtactgg ggccagggca ccctggtgac cgtgtccagc      420

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      480

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      540

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      600

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc      660

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga      720

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac      780

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      840

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg      900

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      960

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1020

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1080

ccccctcgc                                                             1089


<210>  63
<211>  1086
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-19B-2

<400>  63
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gagcggcggc ggactggtgc agccaggagg aagcctgcgg      120

ctgtcctgtg ctgcctccgg ctccatcgtg tccatcgact atatgggctg gtaccggcag      180

gcccccggca agcagaggga gttggtggct ggcatcaact ccggcggctc cacctattac      240

gctgatagcg tgaagggccg gttcaccatc tcccgggaca atgctaagaa caccctgtac      300

ctgcagatga attccctgcg ggccgaggat accgctgtgt actattgtgc tgcccggcag      360

tggtccagcg tggacttcgc ctcctggggc cagggcaccc tggtgacagt gtcctccacc      420

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      480

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      540

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg      600

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa      660

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt      720

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc      780

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag      840

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga      900

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc      960

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1020

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1080

cctcgc                                                                1086


<210>  64
<211>  1116
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  CAR-hu-35B-2

<400>  64
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggaggtgc agctggtgga gtccggcggc ggactggtgc agccaggagg aagcctgagg      120

ctgagctgtg ccgcttccgg caggaccttc agcagctacg ctatgggttg gttcaggcag      180

gcccccggca aggagaggga gttcgtgtcc gccatctcct ggatcggcgg cctgacctac      240

tacgccgact ccgtgaaggg caggttcacc atcagcaggg acaatgctaa gaacaccctg      300

tatctgcaga tgaattccct gagggctgag gacaccgctg tgtactactg tgctgctcac      360

gattgttccg gctatgtgtg ttatgataag gagcccctgt acgagtatga ctactggggc      420

cagggcaccc tggtgaccgt gagcagcacc acgacgccag cgccgcgacc accaacaccg      480

gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      540

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg atatctacat ctgggcgccc      600

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg      660

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact      720

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg      780

agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc      840

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      900

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      960

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1020

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1080

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1116


<210>  65
<211>  246
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-J22.9 scFv

<400>  65

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Ser Val Ile 
            20                  25                  30          


Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Ala Ala Ile Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
145                 150                 155                 160 


Tyr Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp 
            180                 185                 190         


Phe Arg Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  66
<211>  738
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-CAR-J22.9 scFv

<400>  66
gacatcgtgc tgacacagag ccctgccagc ctggccgtga gcctgggaga aagggccacc       60

atcaactgca gggcctccga aagcgtgagc gtgatcggcg cccacctgat ccactggtat      120

cagcagaagc ccggccagcc tcccaagctg ctgatctacc tggccagcaa cctggaaacc      180

ggcgtgcctg ccaggtttag cgggagcggc agcggcaccg atttcaccct gaccatcagc      240

agcctgcagg ccgaggacgc tgccatctac tactgcctgc agtccaggat cttccccagg      300

accttcggcc agggcaccaa gctggagatc aagggcagca ccagcggcag cggcaagccc      360

ggctccggag agggcagcac caagggccag gtgcagctgg tgcagagcgg cagcgagctg      420

aagaaacccg gcgccagcgt gaaggtgagc tgcaaggcca gcggctacac cttcaccgac      480

tacagcatca actgggtgag gcaggcccct ggacagggac tggagtggat gggctggatc      540

aacaccgaga ccagggagcc cgcctacgcc tacgacttca ggggcaggtt cgtgttcagc      600

ctggacacca gcgtgagcac cgcctacctg cagatcagca gcctgaaggc cgaggacacc      660

gccgtgtact actgcgccag ggactacagc tacgccatgg actactgggg ccagggcacc      720

ctggtgacag tgtccagc                                                    738


<210>  67
<211>  1482
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-10-CAR DNA

<400>  67
atggccctgc ctgtgaccgc cctgctgctg cctctggctc tgctgctgca tgccgccaga       60

cccgacatcg tgctgacaca gagccctgcc agcctggccg tgagcctggg agaaagggcc      120

accatcaact gcagggcctc cgaaagcgtg agcgtgatcg gcgcccacct gatccactgg      180

tatcagcaga agcccggcca gcctcccaag ctgctgatct acctggccag caacctggaa      240

accggcgtgc ctgccaggtt tagcgggagc ggcagcggca ccgatttcac cctgaccatc      300

agcagcctgc aggccgagga cgctgccatc tactactgcc tgcagtccag gatcttcccc      360

aggaccttcg gccagggcac caagctggag atcaagggca gcaccagcgg cagcggcaag      420

cccggctccg gagagggcag caccaagggc caggtgcagc tggtgcagag cggcagcgag      480

ctgaagaaac ccggcgccag cgtgaaggtg agctgcaagg ccagcggcta caccttcacc      540

gactacagca tcaactgggt gaggcaggcc cctggacagg gactggagtg gatgggctgg      600

atcaacaccg agaccaggga gcccgcctac gcctacgact tcaggggcag gttcgtgttc      660

agcctggaca ccagcgtgag caccgcctac ctgcagatca gcagcctgaa ggccgaggac      720

accgccgtgt actactgcgc cagggactac agctacgcca tggactactg gggccagggc      780

accctggtga cagtgtccag cgcggccgca accacaacac ctgctccaag gccccccaca      840

cccgctccaa ctatagccag ccaaccattg agcctcagac ctgaagcttg caggcccgca      900

gcaggaggcg ccgtccatac gcgaggcctg gacttcgcgt gtgatattta tatttgggcc      960

cctttggccg gaacatgtgg ggtgttgctt ctctcccttg tgatcactct gtattgtaag     1020

cgcgggagaa agaagctcct gtacatcttc aagcagcctt ttatgcgacc tgtgcaaacc     1080

actcaggaag aagatgggtg ttcatgccgc ttccccgagg aggaagaagg agggtgtgaa     1140

ctgagggtga aattttctag aagcgccgat gctcccgcat atcagcaggg tcagaatcag     1200

ctctacaatg aattgaatct cggcaggcga gaagagtacg atgttctgga caagagacgg     1260

ggcagggatc ccgagatggg gggaaagccc cggagaaaaa atcctcagga ggggttgtac     1320

aatgagctgc agaaggacaa gatggctgaa gcctatagcg agatcggaat gaaaggcgaa     1380

agacgcagag gcaaggggca tgacggtctg taccagggtc tctctacagc caccaaggac     1440

acttatgatg cgttgcatat gcaagccttg ccaccccgct aa                        1482


<210>  68
<211>  493
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  BCMA-10-CAR PRT

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Ala Ala Ile Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ser Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Val Phe Ser Leu Asp Thr 
    210                 215                 220                 


Ser Val Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


