                         SEQUENCE LISTING

<110>  Syngenta
       Li, Jiang
       Xu, Jianping
 
<120>  METHODS AND COMPOSITIONS FOR DNA BASE EDITING

<130>  Attorney Docket Number 81945

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  229
<212>  PRT
<213>  Rattus norvegicus

<400>  1

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys 
225                 


<210>  2
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
atgtccagcg agaccggccc cgtggcggtg gaccccaccc tgcgcaggcg catcgagccg       60

cacgagttcg aggtgttctt cgaccccagg gagctccgca aggagacctg cctcctgtac      120

gagatcaact ggggcggcag gcactccatc tggaggcaca cgagccagaa caccaacaag      180

cacgtcgagg tgaacttcat cgagaagttc accacggaga ggtacttctg cccgaacacg      240

cgctgctcca tcacgtggtt cctctcgtgg agcccatgcg gcgagtgctc cagggcgatc      300

acggagttcc tcagccgcta cccgcacgtg accctgttca tctacatcgc taggctctac      360

caccacgcgg accccaggaa caggcagggc ctcagggacc tgatctccag cggcgtcacg      420

atccagatca tgaccgagca ggagtccggc tactgctgga ggaacttcgt gaactactcc      480

ccgagcaacg aggcccactg gccccgctac ccgcacctct gggtccgcct ctacgtgctc      540

gagctgtact gcatcatcct cggcctgccg ccctgcctca acatcctgag gcgcaagcag      600

ccccagctga cgttcttcac catcgccctg cagagctgcc actaccagag gctcccgccc      660

cacatcctgt gggcgaccgg gctcaag                                          687


<210>  3
<211>  1251
<212>  PRT
<213>  Moraxella bovis

<400>  3

Met Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val 
1               5                   10                  15      


Arg Phe Glu Leu Lys Pro Ile Gly Arg Thr Leu Glu His Ile His Ala 
            20                  25                  30          


Lys Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp Met Tyr Gln Lys 
        35                  40                  45              


Val Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met 
    50                  55                  60                  


Met Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr 
65                  70                  75                  80  


Leu Lys Phe Arg Lys Asn Pro Lys Asp Asp Gly Leu Gln Lys Gln Leu 
                85                  90                  95      


Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ser Val Lys Pro Ile Gly 
            100                 105                 110         


Ser Gly Gly Lys Tyr Lys Thr Gly Tyr Asp Arg Leu Phe Gly Ala Lys 
        115                 120                 125             


Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile 
    130                 135                 140                 


Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His Leu Ala His Phe 
145                 150                 155                 160 


Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn 
                165                 170                 175     


Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile 
            180                 185                 190         


His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr 
        195                 200                 205             


Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu 
    210                 215                 220                 


Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr 
225                 230                 235                 240 


His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr Asn Arg Ile Ile 
                245                 250                 255     


Gly Glu Val Asn Gly Tyr Thr Asn Lys His Asn Gln Ile Cys His Lys 
            260                 265                 270         


Ser Glu Arg Ile Ala Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser 
        275                 280                 285             


Asp Gly Met Gly Val Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser 
    290                 295                 300                 


Glu Met Cys Gln Ala Val Asn Glu Phe Tyr Arg His Tyr Thr Asp Val 
305                 310                 315                 320 


Phe Ala Lys Val Gln Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys 
                325                 330                 335     


Asp Gly Ile Tyr Val Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln 
            340                 345                 350         


Ala Phe Gly Asp Phe Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr 
        355                 360                 365             


Val Asp Val Val Asn Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys 
    370                 375                 380                 


Thr Asp Asn Ala Lys Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile 
385                 390                 395                 400 


Lys Gly Val His Ser Leu Ala Ser Leu Glu Gln Ala Ile Glu His His 
                405                 410                 415     


Thr Ala Arg His Asp Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln 
            420                 425                 430         


Tyr Phe Lys His Gly Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile 
        435                 440                 445             


His Asn Asn His Ser Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro 
    450                 455                 460                 


Ala Gly Glu Arg Ala Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu 
465                 470                 475                 480 


Met Thr Gln Leu Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn 
                485                 490                 495     


Val Ala His Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn 
            500                 505                 510         


Gln Asp Gly Asn Phe Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu 
        515                 520                 525             


Ala Lys Ile Pro Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln 
    530                 535                 540                 


Lys Pro Phe Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr 
545                 550                 555                 560 


Leu Leu Asn Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val 
                565                 570                 575     


Ile Leu Gln Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala 
            580                 585                 590         


His Lys Lys Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Asn Val Tyr 
        595                 600                 605             


Gln Lys Met Val Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro 
    610                 615                 620                 


Lys Val Phe Phe Ala Lys Ser Asn Leu Asp Tyr Tyr Asn Pro Ser Ala 
625                 630                 635                 640 


Glu Leu Leu Asp Lys Tyr Ala Lys Gly Thr His Lys Lys Gly Asp Asn 
                645                 650                 655     


Phe Asn Leu Lys Asp Cys His Ala Leu Ile Asp Phe Phe Lys Ala Gly 
            660                 665                 670         


Ile Asn Lys His Pro Glu Trp Gln His Phe Gly Phe Lys Phe Ser Pro 
        675                 680                 685             


Thr Ser Ser Tyr Arg Asp Leu Ser Asp Phe Tyr Arg Glu Val Glu Pro 
    690                 695                 700                 


Gln Gly Tyr Gln Val Lys Phe Val Asp Ile Asn Ala Asp Tyr Ile Asp 
705                 710                 715                 720 


Glu Leu Val Glu Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
                725                 730                 735     


Asp Phe Ser Pro Lys Ala His Gly Lys Pro Asn Leu His Thr Leu Tyr 
            740                 745                 750         


Phe Lys Ala Leu Phe Ser Glu Asp Asn Leu Ala Asp Pro Ile Tyr Lys 
        755                 760                 765             


Leu Asn Gly Glu Ala Gln Ile Phe Tyr Arg Lys Ala Ser Leu Asp Met 
    770                 775                 780                 


Asn Glu Thr Thr Ile His Arg Ala Gly Glu Val Leu Glu Asn Lys Asn 
785                 790                 795                 800 


Pro Asp Asn Pro Lys Lys Arg Gln Phe Val Tyr Asp Ile Ile Lys Asp 
                805                 810                 815     


Lys Arg Tyr Thr Gln Asp Lys Phe Met Leu His Val Pro Ile Thr Met 
            820                 825                 830         


Asn Phe Gly Val Gln Gly Met Thr Ile Lys Glu Phe Asn Lys Lys Val 
        835                 840                 845             


Asn Gln Ser Ile Gln Gln Tyr Asp Glu Val Asn Val Ile Gly Ile Asp 
    850                 855                 860                 


Arg Gly Glu Arg His Leu Leu Tyr Leu Thr Val Ile Asn Ser Lys Gly 
865                 870                 875                 880 


Glu Ile Leu Glu Gln Arg Ser Leu Asn Asp Ile Thr Thr Ala Ser Ala 
                885                 890                 895     


Asn Gly Thr Gln Val Thr Thr Pro Tyr His Lys Ile Leu Asp Lys Arg 
            900                 905                 910         


Glu Ile Glu Arg Leu Asn Ala Arg Val Gly Trp Gly Glu Ile Glu Thr 
        915                 920                 925             


Ile Lys Glu Leu Lys Ser Gly Tyr Leu Ser His Val Val His Gln Ile 
    930                 935                 940                 


Asn Gln Leu Met Leu Lys Tyr Asn Ala Ile Val Val Leu Glu Asp Leu 
945                 950                 955                 960 


Asn Phe Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln Ile Tyr 
                965                 970                 975     


Gln Asn Phe Glu Asn Ala Leu Ile Lys Lys Leu Asn His Leu Val Leu 
            980                 985                 990         


Lys Asp Lys Ala Asp Asp Glu Ile  Gly Ser Tyr Lys Asn  Ala Leu Gln 
        995                 1000                 1005             


Leu Thr  Asn Asn Phe Thr Asp  Leu Lys Ser Ile Gly  Lys Gln Thr 
    1010                 1015                 1020             


Gly Phe  Leu Phe Tyr Val Pro  Ala Trp Asn Thr Ser  Lys Ile Asp 
    1025                 1030                 1035             


Pro Glu  Thr Gly Phe Val Asp  Leu Leu Lys Pro Arg  Tyr Glu Asn 
    1040                 1045                 1050             


Ile Ala  Gln Ser Gln Ala Phe  Phe Gly Lys Phe Asp  Lys Ile Cys 
    1055                 1060                 1065             


Tyr Asn  Thr Asp Lys Gly Tyr  Phe Glu Phe His Ile  Asp Tyr Ala 
    1070                 1075                 1080             


Lys Phe  Thr Asp Lys Ala Lys  Asn Ser Arg Gln Lys  Trp Ala Ile 
    1085                 1090                 1095             


Cys Ser  His Gly Asp Lys Arg  Tyr Val Tyr Asp Lys  Thr Ala Asn 
    1100                 1105                 1110             


Gln Asn  Lys Gly Ala Ala Lys  Gly Ile Asn Val Asn  Asp Glu Leu 
    1115                 1120                 1125             


Lys Ser  Leu Phe Ala Arg Tyr  His Ile Asn Asp Lys  Gln Pro Asn 
    1130                 1135                 1140             


Leu Val  Met Asp Ile Cys Gln  Asn Asn Asp Lys Glu  Phe His Lys 
    1145                 1150                 1155             


Ser Leu  Met Cys Leu Leu Lys  Thr Leu Leu Ala Leu  Arg Tyr Ser 
    1160                 1165                 1170             


Asn Ala  Ser Ser Asp Glu Asp  Phe Ile Leu Ser Pro  Val Ala Asn 
    1175                 1180                 1185             


Asp Glu  Gly Val Phe Phe Asn  Ser Ala Leu Ala Asp  Asp Thr Gln 
    1190                 1195                 1200             


Pro Gln  Asn Ala Asp Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys 
    1205                 1210                 1215             


Gly Leu  Trp Leu Leu Asn Glu  Leu Lys Asn Ser Asp  Asp Leu Asn 
    1220                 1225                 1230             


Lys Val  Lys Leu Ala Ile Asp  Asn Gln Thr Trp Leu  Asn Phe Ala 
    1235                 1240                 1245             


Gln Asn  Arg 
    1250     


<210>  4
<211>  3753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized

<400>  4
gctctgtttc aagattttac acatctgtac ccgctgagta aaacagtgcg gttcgagctg       60

aaacccatag gaaggaccct cgagcacatc cacgcgaaga attttctgag ccaggatgaa      120

actatggctg atatgtatca aaaagttaag gtcattttgg acgactatca tcgcgatttt      180

attgccgaca tgatgggaga ggtgaaactc acgaagcttg ctgaatttta cgacgtctat      240

ctgaagttca ggaaaaatcc taaggacgat gggctgcaaa aacagcttaa agaccttcaa      300

gctgtccttc ggaaggaatc ggtgaagcct atagggtcag gtgggaagta caaaacaggc      360

tacgatagac tctttggggc aaaactcttc aaagatggaa aagagttggg tgacctcgca      420

aaattcgtta tagcccaaga aggtgagtct tctccgaagc tggctcatct tgctcatttt      480

gagaagttca gcacgtattt tactggattt cacgataatc ggaagaatat gtactcggat      540

gaagacaagc atactgcaat agcgtacagg ctcatccatg agaatttgcc gagattcatc      600

gacaatctgc aaatcttgac aacaatcaaa caaaagcata gcgccctcta tgatcagata      660

atcaacgagc tcacggcctc cgggctcgac gtctccttgg cttctcatct tgacgggtat      720

cacaagctcc ttacacaaga ggggatcacg gcatacaaca ggatcatagg agaggtgaat      780

ggatatacaa ataagcataa ccagatatgc cacaagagcg agcgcatagc gaaacttaga      840

cccttgcaca agcaaatcct ttctgacgga atgggagtgt cattccttcc gtctaagttc      900

gcggatgata gtgagatgtg ccaagcggtc aacgaatttt atcgccatta tactgacgtg      960

ttcgcaaagg tgcaaagtct ctttgacgga tttgatgatc accagaaaga cgggatctat     1020

gttgaacaca aaaaccttaa tgaactgagc aaacaggcgt tcggcgactt tgctttgctg     1080

gggagggtcc ttgatggata ctacgtggac gttgtcaatc cggagttcaa tgagcggttc     1140

gcaaaggcca agactgacaa tgcgaaagcc aagcttacaa aagaaaagga caaattcatt     1200

aaaggagtcc actcactggc ttccctcgaa caagcaatag aacaccatac agctagacac     1260

gacgatgaga gtgttcaagc cggaaaactt ggccagtact tcaaacacgg tttggcgggg     1320

gttgacaacc cgattcagaa aattcacaat aaccattcga cgattaaagg gtttctggaa     1380

agggaaaggc ctgctgggga acgggcgctc ccgaagatca agtcaggaaa aaacccagaa     1440

atgacacagc tcaggcagct gaaggaactt ttggacaacg cattgaatgt ggcgcacttc     1500

gctaagctgc tgacaactaa aacaaccttg gacaaccagg atggaaattt ttacggggag     1560

tttggggtgc tttacgacga gctggctaaa attccaactc tctacaataa ggttagagat     1620

tatctctctc aaaagccctt ttctaccgaa aagtataagc tcaacttcgg caatccgacc     1680

cttctcaatg ggtgggacct gaacaaagag aaagataact ttggggttat acttcagaag     1740

gatggatgct attacttggc gcttcttgat aaggctcata aaaaagtttt cgacaacgcc     1800

cctaacactg gtaagaacgt ctaccaaaag atggtctaca aactgttgcc cggccccaac     1860

aaaatgcttc ctaaagtgtt tttcgcaaaa tcgaatctcg actattataa tccatctgcc     1920

gagctccttg acaaatatgc taaggggacc cataaaaagg gtgataattt caacctgaag     1980

gactgccacg cgcttatcga ctttttcaaa gccgggataa ataagcatcc ggagtggcaa     2040

cattttggtt ttaaattttc gccaacgtcg tcctatcgcg acctttccga tttctatagg     2100

gaagttgaac ctcaggggta ccaggtcaaa tttgttgaca ttaatgcgga ctacattgat     2160

gaattggtgg agcaagggaa gctctacctc tttcaaatat ataacaaaga tttctcgcca     2220

aaagcgcatg gtaaaccgaa tcttcatacc ttgtacttta aagcactttt ttcagaagat     2280

aacttggcgg acccgatcta caagctgaat ggggaagctc agatcttcta caggaaagct     2340

tcgttggaca tgaacgagac taccatacat cgcgcgggag aggtgcttga gaacaaaaat     2400

cccgacaacc cgaaaaagcg gcaattcgtt tacgacatca tcaaagacaa acggtacacg     2460

caggacaaat ttatgctcca cgtccccatt accatgaatt ttggagtcca aggcatgacc     2520

attaaggaat tcaacaaaaa ggtcaaccaa agtattcagc aatacgatga agtcaatgtc     2580

ataggcatag atcggggaga aaggcatctg ttgtatctta ccgtgattaa ctctaagggt     2640

gaaatactgg agcaacggtc acttaacgat ataaccacgg cgtccgcgaa cggtacacaa     2700

gtgaccactc cctaccacaa aatattggat aaaagggaga tagaacgctt gaatgcccgc     2760

gttggctggg gtgagattga gaccatcaaa gagcttaaat cgggatattt gtctcacgtc     2820

gttcatcaaa ttaaccaact catgcttaag tacaatgcaa tcgttgtgct cgaggacctg     2880

aactttggtt tcaaaagagg gaggttcaag gtggaaaaac aaatttacca gaactttgaa     2940

aacgcgctta tcaagaaatt gaatcacctt gttttgaaag ataaggcaga tgacgaaatc     3000

gggtcgtata aaaatgcact ccagttgaca aataatttca cggatttgaa gtcgatcggc     3060

aagcaaacag ggttcctctt ttatgtgcca gcgtggaata catcaaaaat tgatccggag     3120

acgggatttg tcgacttgct gaagcctagg tatgagaaca ttgcccaatc tcaggccttt     3180

ttcggcaaat tcgataaaat atgctacaac acagacaaag gttattttga atttcacatt     3240

gattacgcca aatttacaga taaggcgaaa aacagcagac agaaatgggc tatctgttct     3300

catggggaca aacgctatgt ctacgataag acggctaatc aaaataaagg cgccgcaaaa     3360

ggtattaatg tgaatgatga gctgaaaagc ttgtttgccc gctaccatat caatgataaa     3420

caaccaaact tggtgatgga catatgccag aacaatgaca aagaattcca caagtcactc     3480

atgtgcctgc ttaaaaccct tttggcgctg cggtatagca atgcatctag cgatgaagac     3540

tttattttga gtcccgtggc caacgacgag ggcgtgtttt ttaattcagc cttggcggac     3600

gatacgcagc cccagaatgc ggacgcaaac ggcgcgtacc acattgcact gaagggactg     3660

tggcttctga acgagctgaa aaatagcgac gacctgaata aagtcaagtt ggccattgac     3720

aatcaaacct ggttgaattt cgctcaaaat aga                                  3753


<210>  5
<211>  4367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized fusion protein

<400>  5
atgtccagcg agaccggccc cgtggcggtg gaccccaccc tgcgcaggcg catcgagccg       60

cacgagttcg aggtgttctt cgaccccagg gagctccgca aggagacctg cctcctgtac      120

gagatcaact ggggcggcag gcactccatc tggaggcaca cgagccagaa caccaacaag      180

cacgtcgagg tgaacttcat cgagaagttc accacggaga ggtacttctg cccgaacacg      240

cgctgctcca tcacgtggtt cctctcgtgg agcccatgcg gcgagtgctc cagggcgatc      300

acggagttcc tcagccgcta cccgcacgtg accctgttca tctacatcgc taggctctac      360

caccacgcgg accccaggaa caggcagggc ctcagggacc tgatctccag cggcgtcacg      420

atccagatca tgaccgagca ggagtccggc tactgctgga ggaacttcgt gaactactcc      480

ccgagcaacg aggcccactg gccccgctac ccgcacctct gggtccgcct ctacgtgctc      540

gagctgtact gcatcatcct cggcctgccg ccctgcctca acatcctgag gcgcaagcag      600

ccccagctga cgttcttcac catcgccctg cagagctgcc actaccagag gctcccgccc      660

cacatcctgt gggcgaccgg gctcaagggg ggcgggggct caggcggggg cgggagcggc      720

ggcgggggct ctgggggcgg cggcagcggc gggggcggca gcgggggcgg cgggtcgatg      780

agcaagctgg agaagttcac gaactgctac tccctcagca agaccctgag gttcaaggcg      840

atcccggtcg gcaagaccca ggagaacatc gacaacaagc ggctgctggt ggaggacgag      900

aagagggctg aggactacaa gggcgtgaag aagctcctgg accgctacta cctgtccttc      960

atcaacgacg tgctccacag catcaagctc aagaacctga acaactacat cagcctcttc     1020

aggaagaaga cgcgcaccga gaaggagaac aaggagctcg agaacctgga gatcaacctg     1080

aggaaggaga tcgccaaggc gttcaagggc aacgagggct acaagtccct cttcaagaag     1140

gacatcatcg agacgatcct cccggagttc ctggacgaca aggacgagat cgccctggtc     1200

aactccttca acggcttcac cacggcgttc accggcttct tcgacaaccg cgagaacatg     1260

ttcagcgagg aggccaagtc cacgagcatc gcgttcaggt gcatcaacga gaacctcacc     1320

cgctacatct ccaacatgga catcttcgag aaggtcgacg cgatcttcga caagcacgag     1380

gtgcaggaga tcaaggagaa gatcctgaac agcgactacg acgtcgagga cttcttcgag     1440

ggcgagttct tcaacttcgt cctcacgcag gagggcatcg acgtgtacaa cgccatcatc     1500

ggtggcttcg tgaccgagtc cggcgagaag atcaagggcc tgaacgagta catcaacctc     1560

tacaaccaga agaccaagca gaagctgccg aagttcaagc ccctgtacaa gcaggtgctc     1620

tccgacaggg agtccctcag cttctacggc gagggctaca cgagcgacga ggaggtcctg     1680

gaggtgttcc gcaacaccct caacaagaac agcgagatct tctccagcat caagaagctc     1740

gagaagctgt tcaagaactt cgacgagtac tccagcgccg gcatcttcgt caagaacggc     1800

ccggcgatct ccacgatcag caaggacatc ttcggcgagt ggaacgtgat ccgcgacaag     1860

tggaacgccg agtacgacga catccacctc aagaagaagg cggtggtcac cgagaagtac     1920

gaggacgaca ggcgcaagtc cttcaagaag atcggctcct tcagcctcga gcagctgcag     1980

gagtacgccg acgcggacct gagcgtggtc gagaagctca aggagatcat catccagaag     2040

gtcgacgaga tctacaaggt gtacggctcc agcgagaagc tcttcgacgc ggacttcgtc     2100

ctcgagaagt ccctgaagaa gaacgacgcc gtggtcgcga tcatgaagga cctcctggac     2160

tccgtgaaga gcttcgagaa ttacatcaag gccttcttcg gcgagggcaa ggagacgaac     2220

agggacgagt ccttctacgg cgacttcgtc ctggcctacg acatcctcct gaaggtggac     2280

cacatctacg acgcgatccg caactacgtg acccagaagc cgtacagcaa ggacaagttc     2340

aagctctact tccagaaccc ccagttcatg ggcggctggg acaaggacaa ggagacggac     2400

tacagggcga ccatcctgcg ctacggcagc aagtactacc tcgccatcat ggacaagaag     2460

tacgcgaagt gcctgcagaa gatcgacaag gacgacgtca acggcaacta cgagaagatc     2520

aactacaagc tcctgccggg ccccaacaag atgctcccga aggtgttctt ctccaagaag     2580

tggatggcct actacaaccc cagcgaggac atccagaaga tctacaagaa cggcacgttc     2640

aagaagggcg acatgttcaa cctgaacgac tgccacaagc tcatcgactt cttcaaggac     2700

tccatcagcc gctacccgaa gtggtccaac gcctacgact tcaacttcag cgagaccgag     2760

aagtacaagg acatcgcggg cttctaccgc gaggtcgagg agcagggcta caaggtgtcc     2820

ttcgagtccg ccagcaagaa ggaggtcgac aagctggtgg aggagggcaa gctctacatg     2880

ttccagatct acaacaagga cttctccgac aagagccacg gcacgcccaa cctgcacacc     2940

atgtacttca agctcctgtt cgacgagaac aaccacggcc agatcaggct gtccggcggc     3000

gccgagctct tcatgaggag ggcgagcctg aagaaggagg agctggtggt ccaccccgct     3060

aacagcccaa tcgcgaacaa gaacccggac aaccccaaga agaccacgac cctgtcctac     3120

gacgtgtaca aggacaagag gttcagcgag gaccagtacg agctccacat cccgatcgcg     3180

atcaacaagt gccccaagaa catcttcaag atcaacaccg aggtccgcgt gctcctgaag     3240

cacgacgaca acccctacgt gatcggcatc gctaggggcg agaggaacct cctgtacatc     3300

gtggtcgtgg acggcaaggg caacatcgtg gagcagtact ccctcaacga gatcatcaac     3360

aacttcaacg gcatcaggat caagacggac taccacagcc tcctggacaa gaaggagaag     3420

gagaggttcg aggcccgcca gaactggacc tccatcgaga acatcaagga gctgaaggcg     3480

ggctacatca gccaggtcgt gcacaagatc tgcgagctcg tcgagaagta cgacgccgtg     3540

atcgccctcg cggacctgaa ctccggcttc aagaacagcc gcgtcaaggt ggagaagcag     3600

gtctaccaga agttcgagaa gatgctcatc gacaagctga actacatggt ggacaagaag     3660

tccaacccct gcgctacggg cggcgcgctg aagggctacc agatcaccaa caagttcgag     3720

agcttcaagt ccatgagcac tcagaacggc ttcatcttct acatcccggc gtggctcacg     3780

tccaagatcg accccagcac cggcttcgtc aacctcctga agacgaagta cacctccatc     3840

gccgacagca agaagttcat ctccagcttc gaccgcatca tgtatgtgcc ggaggaggac     3900

ctgttcgagt tcgccctcga ctacaagaac ttctcccgca cggacgcgga ctacatcaag     3960

aagtggaagc tgtacagcta cggcaaccgc atccgcatct tcaggaaccc caagaagaac     4020

aacgtcttcg actgggagga ggtgtgcctg acctccgcgt acaaggagct cttcaacaag     4080

tacggcatca actaccagca gggcgacatc agggctctcc tgtgcgagca gagcgacaag     4140

gccttctact ccagcttcat ggcgctgatg tccctcatgc tgcagatgag gaactcgatc     4200

accggcagga cggacgtggc cttcctcatc tccccggtga agaacagcga cggcatcttc     4260

tacgactcca ggaactacga ggcccaggag aacgcgatcc tcccaaagaa cgcggacgcc     4320

aacggcgcct acaacatcgc caggaaggtc ctctgggcta tcggcca                   4367


<210>  6
<211>  1455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  6

Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg 
1               5                   10                  15      


Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu 
            20                  25                  30          


Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His 
        35                  40                  45              


Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val 
    50                  55                  60                  


Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr 
65                  70                  75                  80  


Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys 
                85                  90                  95      


Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu 
            100                 105                 110         


Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg 
        115                 120                 125             


Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met 
    130                 135                 140                 


Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser 
145                 150                 155                 160 


Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg 
                165                 170                 175     


Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys 
            180                 185                 190         


Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile 
        195                 200                 205             


Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp 
    210                 215                 220                 


Ala Thr Gly Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu 
            260                 265                 270         


Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu 
        275                 280                 285             


Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu 
    290                 295                 300                 


Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe 
305                 310                 315                 320 


Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr 
                325                 330                 335     


Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu 
            340                 345                 350         


Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe 
        355                 360                 365             


Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu 
    370                 375                 380                 


Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val 
385                 390                 395                 400 


Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn 
                405                 410                 415     


Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe 
            420                 425                 430         


Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile 
        435                 440                 445             


Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile 
    450                 455                 460                 


Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu 
465                 470                 475                 480 


Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr 
                485                 490                 495     


Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys 
            500                 505                 510         


Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys 
        515                 520                 525             


Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu 
    530                 535                 540                 


Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu 
545                 550                 555                 560 


Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser 
                565                 570                 575     


Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser 
            580                 585                 590         


Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys 
        595                 600                 605             


Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu 
    610                 615                 620                 


Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr 
625                 630                 635                 640 


Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu 
                645                 650                 655     


Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys 
            660                 665                 670         


Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr 
        675                 680                 685             


Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser 
    690                 695                 700                 


Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp 
705                 710                 715                 720 


Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly 
                725                 730                 735     


Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala 
            740                 745                 750         


Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn 
        755                 760                 765             


Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe 
    770                 775                 780                 


Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp 
785                 790                 795                 800 


Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile 
                805                 810                 815     


Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp 
            820                 825                 830         


Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro 
        835                 840                 845             


Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr 
    850                 855                 860                 


Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe 
865                 870                 875                 880 


Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp 
                885                 890                 895     


Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr 
            900                 905                 910         


Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe 
        915                 920                 925             


Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala 
    930                 935                 940                 


Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met 
945                 950                 955                 960 


Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro 
                965                 970                 975     


Asn Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His 
            980                 985                 990         


Gly Gln Ile Arg Leu Ser Gly Gly  Ala Glu Leu Phe Met  Arg Arg Ala 
        995                 1000                 1005             


Ser Leu  Lys Lys Glu Glu Leu  Val Val His Pro Ala  Asn Ser Pro 
    1010                 1015                 1020             


Ile Ala  Asn Lys Asn Pro Asp  Asn Pro Lys Lys Thr  Thr Thr Leu 
    1025                 1030                 1035             


Ser Tyr  Asp Val Tyr Lys Asp  Lys Arg Phe Ser Glu  Asp Gln Tyr 
    1040                 1045                 1050             


Glu Leu  His Ile Pro Ile Ala  Ile Asn Lys Cys Pro  Lys Asn Ile 
    1055                 1060                 1065             


Phe Lys  Ile Asn Thr Glu Val  Arg Val Leu Leu Lys  His Asp Asp 
    1070                 1075                 1080             


Asn Pro  Tyr Val Ile Gly Ile  Ala Arg Gly Glu Arg  Asn Leu Leu 
    1085                 1090                 1095             


Tyr Ile  Val Val Val Asp Gly  Lys Gly Asn Ile Val  Glu Gln Tyr 
    1100                 1105                 1110             


Ser Leu  Asn Glu Ile Ile Asn  Asn Phe Asn Gly Ile  Arg Ile Lys 
    1115                 1120                 1125             


Thr Asp  Tyr His Ser Leu Leu  Asp Lys Lys Glu Lys  Glu Arg Phe 
    1130                 1135                 1140             


Glu Ala  Arg Gln Asn Trp Thr  Ser Ile Glu Asn Ile  Lys Glu Leu 
    1145                 1150                 1155             


Lys Ala  Gly Tyr Ile Ser Gln  Val Val His Lys Ile  Cys Glu Leu 
    1160                 1165                 1170             


Val Glu  Lys Tyr Asp Ala Val  Ile Ala Leu Ala Asp  Leu Asn Ser 
    1175                 1180                 1185             


Gly Phe  Lys Asn Ser Arg Val  Lys Val Glu Lys Gln  Val Tyr Gln 
    1190                 1195                 1200             


Lys Phe  Glu Lys Met Leu Ile  Asp Lys Leu Asn Tyr  Met Val Asp 
    1205                 1210                 1215             


Lys Lys  Ser Asn Pro Cys Ala  Thr Gly Gly Ala Leu  Lys Gly Tyr 
    1220                 1225                 1230             


Gln Ile  Thr Asn Lys Phe Glu  Ser Phe Lys Ser Met  Ser Thr Gln 
    1235                 1240                 1245             


Asn Gly  Phe Ile Phe Tyr Ile  Pro Ala Trp Leu Thr  Ser Lys Ile 
    1250                 1255                 1260             


Asp Pro  Ser Thr Gly Phe Val  Asn Leu Leu Lys Thr  Lys Tyr Thr 
    1265                 1270                 1275             


Ser Ile  Ala Asp Ser Lys Lys  Phe Ile Ser Ser Phe  Asp Arg Ile 
    1280                 1285                 1290             


Met Tyr  Val Pro Glu Glu Asp  Leu Phe Glu Phe Ala  Leu Asp Tyr 
    1295                 1300                 1305             


Lys Asn  Phe Ser Arg Thr Asp  Ala Asp Tyr Ile Lys  Lys Trp Lys 
    1310                 1315                 1320             


Leu Tyr  Ser Tyr Gly Asn Arg  Ile Arg Ile Phe Arg  Asn Pro Lys 
    1325                 1330                 1335             


Lys Asn  Asn Val Phe Asp Trp  Glu Glu Val Cys Leu  Thr Ser Ala 
    1340                 1345                 1350             


Tyr Lys  Glu Leu Phe Asn Lys  Tyr Gly Ile Asn Tyr  Gln Gln Gly 
    1355                 1360                 1365             


Asp Ile  Arg Ala Leu Leu Cys  Glu Gln Ser Asp Lys  Ala Phe Tyr 
    1370                 1375                 1380             


Ser Ser  Phe Met Ala Leu Met  Ser Leu Met Leu Gln  Met Arg Asn 
    1385                 1390                 1395             


Ser Ile  Thr Gly Arg Thr Asp  Val Ala Phe Leu Ile  Ser Pro Val 
    1400                 1405                 1410             


Lys Asn  Ser Asp Gly Ile Phe  Tyr Asp Ser Arg Asn  Tyr Glu Ala 
    1415                 1420                 1425             


Gln Glu  Asn Ala Ile Leu Pro  Lys Asn Ala Asp Ala  Asn Gly Ala 
    1430                 1435                 1440             


Tyr Asn  Ile Ala Arg Lys Val  Leu Trp Ala Ile Gly  
    1445                 1450                 1455 


<210>  7
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized

<400>  7
acgaacctgt ccgacatcat cgagaaggag accggcaagc agctcgtgat ccaggagagc       60

atcctcatgc tgccggagga ggtcgaggag gtcatcggca acaagcccga gtccgacatc      120

ctcgtccaca cggcctacga cgagtccacc gacgagaacg tgatgctcct gacctcggac      180

gctcccgagt acaagccatg ggccctggtc atccaggaca gcaacggcga gaacaagatc      240

aagatgctc                                                              249


<210>  8
<211>  83
<212>  PRT
<213>  Bacillus subtilis phage PBSX

<400>  8

Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr Gly Lys Gln Leu Val 
1               5                   10                  15      


Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val Ile 
            20                  25                  30          


Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp Glu 
        35                  40                  45              


Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu Tyr 
    50                  55                  60                  


Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys Ile 
65                  70                  75                  80  


Lys Met Leu 
            


<210>  9
<211>  6882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized fusion

<400>  9
gaattcatta tgtggtctag gtaggttcta tatataagaa aacttgaaat gttctaaaaa       60

aaaattcaag cccatgcatg attgaagcaa acggtatagc aacggtgtta acctgatcta      120

gtgatctctt gcaatcctta acggccacct accgcaggta gcaaacggcg tccccctcct      180

cgatatctcc gcggcgacct ctggcttttt ccgcggaatt gcgcggtggg gacggattcc      240

acgagaccgc gacgcaaccg cctctcgccg ctgggcccca caccgctcgg tgccgtagcc      300

tcacgggact ctttctccct cctcccccgt tataaattgg cttcatcccc tccttgcctc      360

atccatccaa atcccagtcc ccaatcccat cccttcgtag gagaaattca tcgaagctaa      420

gcgaatcctc gcgatcctct caaggtactg cgagttttcg atccccctct cgacccctcg      480

tatgtttgtg tttgtcgtag cgtttgatta ggtatgcttt ccctgtttgt gttcgtcgta      540

gcgtttgatt aggtatgctt tccctgttcg tgttcatcgt agtgtttgat taggtcgtgt      600

gaggcgatgg cctgctcgcg tccttcgatc tgtagtcgat ttgcgggtcg tggtgtagat      660

ctgcgggctg tgatgaagtt atttggtgtg atctgctcgc ctgattctgc gggttggctc      720

gagtagatat gatggttgga ccggttggtt cgtttaccgc gctagggttg ggctgggatg      780

atgttgcatg cgccgttgcg cgtgatcccg cagcaggact tgcgtttgat tgccagatct      840

cgttacgatt atgtgatttg gtttggactt tttagatctg tagcttctgc ttatgtgcca      900

gatgcgccta ctgctcatat gcctgatgat aatcataaat ggctgtggaa ctaactagtt      960

gattgcggag tcatgtatca gctacaggtg tagggactag ctacaggtgt agggacttgc     1020

gtctaattgt ttggtccttt actcatgttg caattatgca atttagttta gattgtttgt     1080

tccactcatc taggctgtaa aagggacact gcttagattg ctgtttaatc tttttagtag     1140

attatattat attggtaact tattacccct attacatgcc atacgtgact tctgctcatg     1200

cctgatgata atcatagatc actgtggaat taattagttg attgttgaat catgtttcat     1260

gtacatacca cggcacaatt gcttagttcc ttaacaaatg caaattttac tgatccatgt     1320

atgatttgcg tggttctcta atgtgaaata ctatagctac ttgttagtaa gaatcaggtt     1380

cgtatgctta atgctgtatg tgccttctgc tcatgcctga tgataatcat atatcactgg     1440

aattaattag ttgatcgttt aatcatatat caagtacata ccatgccaca atttttagtc     1500

acttaaccca tgcagattga actggtccct gcatgttttg ctaaattgtt ctattctgat     1560

tagaccatat atcatgtatt tttttttggt aatggttctc ttattttaaa tgctatatag     1620

ttctggtact tgttagaaag atctgcttca tagtttagtt gcctatccct cgaattagga     1680

tgctgagcag ctgatcctat agctttgttt catgtatcaa ttcttttgtg ttcaacagtc     1740

agtttttgtt agattcattg taacttatgg tcgcttactc ttctggtcct caatgcttgc     1800

agggatcccc taaatagacc atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg     1860

gccccgtggc ggtggacccc accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt     1920

tcttcgaccc cagggagctc cgcaaggaga cctgcctcct gtacgagatc aactggggcg     1980

gcaggcactc catctggagg cacacgagcc agaacaccaa caagcacgtc gaggtgaact     2040

tcatcgagaa gttcaccacg gagaggtact tctgcccgaa cacgcgctgc tccatcacgt     2100

ggttcctctc gtggagccca tgcggcgagt gctccagggc gatcacggag ttcctcagcc     2160

gctacccgca cgtgaccctg ttcatctaca tcgctaggct ctaccaccac gcggacccca     2220

ggaacaggca gggcctcagg gacctgatct ccagcggcgt cacgatccag atcatgaccg     2280

agcaggagtc cggctactgc tggaggaact tcgtgaacta ctccccgagc aacgaggccc     2340

actggccccg ctacccgcac ctctgggtcc gcctctacgt gctcgagctg tactgcatca     2400

tcctcggcct gccgccctgc ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct     2460

tcaccatcgc cctgcagagc tgccactacc agaggctccc gccccacatc ctgtgggcga     2520

ccgggctcaa ggggggcggg ggctcaggcg ggggcgggag cggcggcggg ggctctgggg     2580

gcggcggcag cggcgggggc ggcagcgggg gcggcgggtc gatgagcaag ctggagaagt     2640

tcacgaactg ctactccctc agcaagaccc tgaggttcaa ggcgatcccg gtcggcaaga     2700

cccaggagaa catcgacaac aagcggctgc tggtggagga cgagaagagg gctgaggact     2760

acaagggcgt gaagaagctc ctggaccgct actacctgtc cttcatcaac gacgtgctcc     2820

acagcatcaa gctcaagaac ctgaacaact acatcagcct cttcaggaag aagacgcgca     2880

ccgagaagga gaacaaggag ctcgagaacc tggagatcaa cctgaggaag gagatcgcca     2940

aggcgttcaa gggcaacgag ggctacaagt ccctcttcaa gaaggacatc atcgagacga     3000

tcctcccgga gttcctggac gacaaggacg agatcgccct ggtcaactcc ttcaacggct     3060

tcaccacggc gttcaccggc ttcttcgaca accgcgagaa catgttcagc gaggaggcca     3120

agtccacgag catcgcgttc aggtgcatca acgagaacct cacccgctac atctccaaca     3180

tggacatctt cgagaaggtc gacgcgatct tcgacaagca cgaggtgcag gagatcaagg     3240

agaagatcct gaacagcgac tacgacgtcg aggacttctt cgagggcgag ttcttcaact     3300

tcgtcctcac gcaggagggc atcgacgtgt acaacgccat catcggtggc ttcgtgaccg     3360

agtccggcga gaagatcaag ggcctgaacg agtacatcaa cctctacaac cagaagacca     3420

agcagaagct gccgaagttc aagcccctgt acaagcaggt gctctccgac agggagtccc     3480

tcagcttcta cggcgagggc tacacgagcg acgaggaggt cctggaggtg ttccgcaaca     3540

ccctcaacaa gaacagcgag atcttctcca gcatcaagaa gctcgagaag ctgttcaaga     3600

acttcgacga gtactccagc gccggcatct tcgtcaagaa cggcccggcg atctccacga     3660

tcagcaagga catcttcggc gagtggaacg tgatccgcga caagtggaac gccgagtacg     3720

acgacatcca cctcaagaag aaggcggtgg tcaccgagaa gtacgaggac gacaggcgca     3780

agtccttcaa gaagatcggc tccttcagcc tcgagcagct gcaggagtac gccgacgcgg     3840

acctgagcgt ggtcgagaag ctcaaggaga tcatcatcca gaaggtcgac gagatctaca     3900

aggtgtacgg ctccagcgag aagctcttcg acgcggactt cgtcctcgag aagtccctga     3960

agaagaacga cgccgtggtc gcgatcatga aggacctcct ggactccgtg aagagcttcg     4020

agaattacat caaggccttc ttcggcgagg gcaaggagac gaacagggac gagtccttct     4080

acggcgactt cgtcctggcc tacgacatcc tcctgaaggt ggaccacatc tacgacgcga     4140

tccgcaacta cgtgacccag aagccgtaca gcaaggacaa gttcaagctc tacttccaga     4200

acccccagtt catgggcggc tgggacaagg acaaggagac ggactacagg gcgaccatcc     4260

tgcgctacgg cagcaagtac tacctcgcca tcatggacaa gaagtacgcg aagtgcctgc     4320

agaagatcga caaggacgac gtcaacggca actacgagaa gatcaactac aagctcctgc     4380

cgggccccaa caagatgctc ccgaaggtgt tcttctccaa gaagtggatg gcctactaca     4440

accccagcga ggacatccag aagatctaca agaacggcac gttcaagaag ggcgacatgt     4500

tcaacctgaa cgactgccac aagctcatcg acttcttcaa ggactccatc agccgctacc     4560

cgaagtggtc caacgcctac gacttcaact tcagcgagac cgagaagtac aaggacatcg     4620

cgggcttcta ccgcgaggtc gaggagcagg gctacaaggt gtccttcgag tccgccagca     4680

agaaggaggt cgacaagctg gtggaggagg gcaagctcta catgttccag atctacaaca     4740

aggacttctc cgacaagagc cacggcacgc ccaacctgca caccatgtac ttcaagctcc     4800

tgttcgacga gaacaaccac ggccagatca ggctgtccgg cggcgccgag ctcttcatga     4860

ggagggcgag cctgaagaag gaggagctgg tggtccaccc cgctaacagc ccaatcgcga     4920

acaagaaccc ggacaacccc aagaagacca cgaccctgtc ctacgacgtg tacaaggaca     4980

agaggttcag cgaggaccag tacgagctcc acatcccgat cgcgatcaac aagtgcccca     5040

agaacatctt caagatcaac accgaggtcc gcgtgctcct gaagcacgac gacaacccct     5100

acgtgatcgg catcgctagg ggcgagagga acctcctgta catcgtggtc gtggacggca     5160

agggcaacat cgtggagcag tactccctca acgagatcat caacaacttc aacggcatca     5220

ggatcaagac ggactaccac agcctcctgg acaagaagga gaaggagagg ttcgaggccc     5280

gccagaactg gacctccatc gagaacatca aggagctgaa ggcgggctac atcagccagg     5340

tcgtgcacaa gatctgcgag ctcgtcgaga agtacgacgc cgtgatcgcc ctcgcggacc     5400

tgaactccgg cttcaagaac agccgcgtca aggtggagaa gcaggtctac cagaagttcg     5460

agaagatgct catcgacaag ctgaactaca tggtggacaa gaagtccaac ccctgcgcta     5520

cgggcggcgc gctgaagggc taccagatca ccaacaagtt cgagagcttc aagtccatga     5580

gcactcagaa cggcttcatc ttctacatcc cggcgtggct cacgtccaag atcgacccca     5640

gcaccggctt cgtcaacctc ctgaagacga agtacacctc catcgccgac agcaagaagt     5700

tcatctccag cttcgaccgc atcatgtatg tgccggagga ggacctgttc gagttcgccc     5760

tcgactacaa gaacttctcc cgcacggacg cggactacat caagaagtgg aagctgtaca     5820

gctacggcaa ccgcatccgc atcttcagga accccaagaa gaacaacgtc ttcgactggg     5880

aggaggtgtg cctgacctcc gcgtacaagg agctcttcaa caagtacggc atcaactacc     5940

agcagggcga catcagggct ctcctgtgcg agcagagcga caaggccttc tactccagct     6000

tcatggcgct gatgtccctc atgctgcaga tgaggaactc gatcaccggc aggacggacg     6060

tggccttcct catctccccg gtgaagaaca gcgacggcat cttctacgac tccaggaact     6120

acgaggccca ggagaacgcg atcctcccaa agaacgcgga cgccaacggc gcctacaaca     6180

tcgccaggaa ggtcctctgg gctatcggcc agttcaagaa ggcggaggac gagaagctgg     6240

acaaggtgaa gatcgccatc agcaacaagg agtggctcga gtacgcccag acctcggtca     6300

agcacggcag cccgaagaag aagcgcaagg tgtccggcgg cagcacgaac ctgtccgaca     6360

tcatcgagaa ggagaccggc aagcagctcg tgatccagga gagcatcctc atgctgccgg     6420

aggaggtcga ggaggtcatc ggcaacaagc ccgagtccga catcctcgtc cacacggcct     6480

acgacgagtc caccgacgag aacgtgatgc tcctgacctc ggacgctccc gagtacaagc     6540

catgggccct ggtcatccag gacagcaacg gcgagaacaa gatcaagatg ctctccggcg     6600

gcagcccgaa gaagaagcgc aaagtgtgag atcgttcaaa catttggcaa taaagtttct     6660

taagattgaa tcctgttgcc ggtcttgcga tgattatcat ataatttctg ttgaattacg     6720

ttaagcatgt aataattaac atgtaatgca tgacgttatt tatgagatgg gtttttatga     6780

ttagagtccc gcaattatac atttaatacg cgatagaaaa caaaatatag cgcgcaaact     6840

aggataaatt atcgcgcgcg gtgtcatcta tgttactaga tc                        6882


<210>  10
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
gggggcgggg gctcaggcgg gggcgggagc ggcggcgggg gctctggggg cggcggcagc       60

ggcgggggcg gcagcggggg cggcgggtcg                                        90


<210>  11
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Gly Ser Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly 
        


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14
<211>  4842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized fusion

<400>  14
atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg gccccgtggc ggtggacccc       60

accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt tcttcgaccc cagggagctc      120

cgcaaggaga cctgcctcct gtacgagatc aactggggcg gcaggcactc catctggagg      180

cacacgagcc agaacaccaa caagcacgtc gaggtgaact tcatcgagaa gttcaccacg      240

gagaggtact tctgcccgaa cacgcgctgc tccatcacgt ggttcctctc gtggagccca      300

tgcggcgagt gctccagggc gatcacggag ttcctcagcc gctacccgca cgtgaccctg      360

ttcatctaca tcgctaggct ctaccaccac gcggacccca ggaacaggca gggcctcagg      420

gacctgatct ccagcggcgt cacgatccag atcatgaccg agcaggagtc cggctactgc      480

tggaggaact tcgtgaacta ctccccgagc aacgaggccc actggccccg ctacccgcac      540

ctctgggtcc gcctctacgt gctcgagctg tactgcatca tcctcggcct gccgccctgc      600

ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct tcaccatcgc cctgcagagc      660

tgccactacc agaggctccc gccccacatc ctgtgggcga ccgggctcaa gtcgggcagc      720

gagacccccg gcacctccga gtcggctacc ccagagtcca tgagcaagct ggagaagttc      780

acgaactgct actccctcag caagaccctg aggttcaagg cgatcccggt cggcaagacc      840

caggagaaca tcgacaacaa gcggctgctg gtggaggacg agaagagggc tgaggactac      900

aagggcgtga agaagctcct ggaccgctac tacctgtcct tcatcaacga cgtgctccac      960

agcatcaagc tcaagaacct gaacaactac atcagcctct tcaggaagaa gacgcgcacc     1020

gagaaggaga acaaggagct cgagaacctg gagatcaacc tgaggaagga gatcgccaag     1080

gcgttcaagg gcaacgaggg ctacaagtcc ctcttcaaga aggacatcat cgagacgatc     1140

ctcccggagt tcctggacga caaggacgag atcgccctgg tcaactcctt caacggcttc     1200

accacggcgt tcaccggctt cttcgacaac cgcgagaaca tgttcagcga ggaggccaag     1260

tccacgagca tcgcgttcag gtgcatcaac gagaacctca cccgctacat ctccaacatg     1320

gacatcttcg agaaggtcga cgcgatcttc gacaagcacg aggtgcagga gatcaaggag     1380

aagatcctga acagcgacta cgacgtcgag gacttcttcg agggcgagtt cttcaacttc     1440

gtcctcacgc aggagggcat cgacgtgtac aacgccatca tcggtggctt cgtgaccgag     1500

tccggcgaga agatcaaggg cctgaacgag tacatcaacc tctacaacca gaagaccaag     1560

cagaagctgc cgaagttcaa gcccctgtac aagcaggtgc tctccgacag ggagtccctc     1620

agcttctacg gcgagggcta cacgagcgac gaggaggtcc tggaggtgtt ccgcaacacc     1680

ctcaacaaga acagcgagat cttctccagc atcaagaagc tcgagaagct gttcaagaac     1740

ttcgacgagt actccagcgc cggcatcttc gtcaagaacg gcccggcgat ctccacgatc     1800

agcaaggaca tcttcggcga gtggaacgtg atccgcgaca agtggaacgc cgagtacgac     1860

gacatccacc tcaagaagaa ggcggtggtc accgagaagt acgaggacga caggcgcaag     1920

tccttcaaga agatcggctc cttcagcctc gagcagctgc aggagtacgc cgacgcggac     1980

ctgagcgtgg tcgagaagct caaggagatc atcatccaga aggtcgacga gatctacaag     2040

gtgtacggct ccagcgagaa gctcttcgac gcggacttcg tcctcgagaa gtccctgaag     2100

aagaacgacg ccgtggtcgc gatcatgaag gacctcctgg actccgtgaa gagcttcgag     2160

aattacatca aggccttctt cggcgagggc aaggagacga acagggacga gtccttctac     2220

ggcgacttcg tcctggccta cgacatcctc ctgaaggtgg accacatcta cgacgcgatc     2280

cgcaactacg tgacccagaa gccgtacagc aaggacaagt tcaagctcta cttccagaac     2340

ccccagttca tgggcggctg ggacaaggac aaggagacgg actacagggc gaccatcctg     2400

cgctacggca gcaagtacta cctcgccatc atggacaaga agtacgcgaa gtgcctgcag     2460

aagatcgaca aggacgacgt caacggcaac tacgagaaga tcaactacaa gctcctgccg     2520

ggccccaaca agatgctccc gaaggtgttc ttctccaaga agtggatggc ctactacaac     2580

cccagcgagg acatccagaa gatctacaag aacggcacgt tcaagaaggg cgacatgttc     2640

aacctgaacg actgccacaa gctcatcgac ttcttcaagg actccatcag ccgctacccg     2700

aagtggtcca acgcctacga cttcaacttc agcgagaccg agaagtacaa ggacatcgcg     2760

ggcttctacc gcgaggtcga ggagcagggc tacaaggtgt ccttcgagtc cgccagcaag     2820

aaggaggtcg acaagctggt ggaggagggc aagctctaca tgttccagat ctacaacaag     2880

gacttctccg acaagagcca cggcacgccc aacctgcaca ccatgtactt caagctcctg     2940

ttcgacgaga acaaccacgg ccagatcagg ctgtccggcg gcgccgagct cttcatgagg     3000

agggcgagcc tgaagaagga ggagctggtg gtccaccccg ctaacagccc aatcgcgaac     3060

aagaacccgg acaaccccaa gaagaccacg accctgtcct acgacgtgta caaggacaag     3120

aggttcagcg aggaccagta cgagctccac atcccgatcg cgatcaacaa gtgccccaag     3180

aacatcttca agatcaacac cgaggtccgc gtgctcctga agcacgacga caacccctac     3240

gtgatcggca tcgctagggg cgagaggaac ctcctgtaca tcgtggtcgt ggacggcaag     3300

ggcaacatcg tggagcagta ctccctcaac gagatcatca acaacttcaa cggcatcagg     3360

atcaagacgg actaccacag cctcctggac aagaaggaga aggagaggtt cgaggcccgc     3420

cagaactgga cctccatcga gaacatcaag gagctgaagg cgggctacat cagccaggtc     3480

gtgcacaaga tctgcgagct cgtcgagaag tacgacgccg tgatcgccct cgcggacctg     3540

aactccggct tcaagaacag ccgcgtcaag gtggagaagc aggtctacca gaagttcgag     3600

aagatgctca tcgacaagct gaactacatg gtggacaaga agtccaaccc ctgcgctacg     3660

ggcggcgcgc tgaagggcta ccagatcacc aacaagttcg agagcttcaa gtccatgagc     3720

actcagaacg gcttcatctt ctacatcccg gcgtggctca cgtccaagat cgaccccagc     3780

accggcttcg tcaacctcct gaagacgaag tacacctcca tcgccgacag caagaagttc     3840

atctccagct tcgaccgcat catgtatgtg ccggaggagg acctgttcga gttcgccctc     3900

gactacaaga acttctcccg cacggacgcg gactacatca agaagtggaa gctgtacagc     3960

tacggcaacc gcatccgcat cttcaggaac cccaagaaga acaacgtctt cgactgggag     4020

gaggtgtgcc tgacctccgc gtacaaggag ctcttcaaca agtacggcat caactaccag     4080

cagggcgaca tcagggctct cctgtgcgag cagagcgaca aggccttcta ctccagcttc     4140

atggcgctga tgtccctcat gctgcagatg aggaactcga tcaccggcag gacggacgtg     4200

gccttcctca tctccccggt gaagaacagc gacggcatct tctacgactc caggaactac     4260

gaggcccagg agaacgcgat cctcccaaag aacgcggacg ccaacggcgc ctacaacatc     4320

gccaggaagg tcctctgggc tatcggccag ttcaagaagg cggaggacga gaagctggac     4380

aaggtgaaga tcgccatcag caacaaggag tggctcgagt acgcccagac ctcggtcaag     4440

cacggcagcc cgaagaagaa gcgcaaggtg ggagggtcga caggaggcgg ttctggcgga     4500

ggttcaggtg gaggctcgag tggtacgaac ctgtccgaca tcatcgagaa ggagaccggc     4560

aagcagctcg tgatccagga gagcatcctc atgctgccgg aggaggtcga ggaggtcatc     4620

ggcaacaagc ccgagtccga catcctcgtc cacacggcct acgacgagtc caccgacgag     4680

aacgtgatgc tcctgacctc ggacgctccc gagtacaagc catgggccct ggtcatccag     4740

gacagcaacg gcgagaacaa gatcaagatg ctcggtggag gcggttcagg cggaggtggc     4800

tctggcggtg gcggatcgcc gaagaagaag cgcaaagtgt ga                        4842


<210>  15
<211>  1613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Pro Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val 
1               5                   10                  15      


Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu 
            20                  25                  30          


Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr 
        35                  40                  45              


Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln 
    50                  55                  60                  


Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr 
65                  70                  75                  80  


Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu 
                85                  90                  95      


Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu 
            100                 105                 110         


Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr 
        115                 120                 125             


His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser 
    130                 135                 140                 


Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys 
145                 150                 155                 160 


Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro 
                165                 170                 175     


Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys 
            180                 185                 190         


Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln 
        195                 200                 205             


Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln 
    210                 215                 220                 


Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser Gly Ser 
225                 230                 235                 240 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met Ser Lys 
                245                 250                 255     


Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe 
            260                 265                 270         


Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg 
        275                 280                 285             


Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys 
    290                 295                 300                 


Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His 
305                 310                 315                 320 


Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys 
                325                 330                 335     


Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile 
            340                 345                 350         


Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr 
        355                 360                 365             


Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe 
    370                 375                 380                 


Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe 
385                 390                 395                 400 


Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser 
                405                 410                 415     


Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn 
            420                 425                 430         


Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala 
        435                 440                 445             


Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn 
    450                 455                 460                 


Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe 
465                 470                 475                 480 


Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly 
                485                 490                 495     


Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile 
            500                 505                 510         


Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro 
        515                 520                 525             


Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly 
    530                 535                 540                 


Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr 
545                 550                 555                 560 


Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys 
                565                 570                 575     


Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys 
            580                 585                 590         


Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp 
        595                 600                 605             


Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu 
    610                 615                 620                 


Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys 
625                 630                 635                 640 


Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr 
                645                 650                 655     


Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile 
            660                 665                 670         


Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu 
        675                 680                 685             


Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala 
    690                 695                 700                 


Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu 
705                 710                 715                 720 


Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp 
                725                 730                 735     


Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys 
            740                 745                 750         


Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro 
        755                 760                 765             


Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met 
    770                 775                 780                 


Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu 
785                 790                 795                 800 


Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala 
                805                 810                 815     


Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu 
            820                 825                 830         


Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys 
        835                 840                 845             


Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp 
    850                 855                 860                 


Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe 
865                 870                 875                 880 


Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile 
                885                 890                 895     


Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu 
            900                 905                 910         


Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu 
        915                 920                 925             


Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp 
    930                 935                 940                 


Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys 
945                 950                 955                 960 


Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr 
                965                 970                 975     


Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg Leu Ser 
            980                 985                 990         


Gly Gly Ala Glu Leu Phe Met Arg  Arg Ala Ser Leu Lys  Lys Glu Glu 
        995                 1000                 1005             


Leu Val  Val His Pro Ala Asn  Ser Pro Ile Ala Asn  Lys Asn Pro 
    1010                 1015                 1020             


Asp Asn  Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
    1025                 1030                 1035             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1040                 1045                 1050             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1055                 1060                 1065             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1070                 1075                 1080             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1085                 1090                 1095             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1100                 1105                 1110             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1115                 1120                 1125             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1130                 1135                 1140             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1145                 1150                 1155             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1160                 1165                 1170             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1175                 1180                 1185             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1190                 1195                 1200             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1205                 1210                 1215             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1220                 1225                 1230             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1235                 1240                 1245             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1250                 1255                 1260             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1265                 1270                 1275             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1280                 1285                 1290             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1295                 1300                 1305             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1310                 1315                 1320             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1325                 1330                 1335             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1340                 1345                 1350             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1355                 1360                 1365             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1370                 1375                 1380             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1385                 1390                 1395             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1400                 1405                 1410             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1415                 1420                 1425             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1430                 1435                 1440             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1445                 1450                 1455             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1460                 1465                 1470             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1475                 1480                 1485             


Lys Val  Gly Gly Ser Thr Gly  Gly Gly Ser Gly Gly  Gly Ser Gly 
    1490                 1495                 1500             


Gly Gly  Ser Ser Gly Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1505                 1510                 1515             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1520                 1525                 1530             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1535                 1540                 1545             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1550                 1555                 1560             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1565                 1570                 1575             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Gly Gly 
    1580                 1585                 1590             


Gly Gly  Ser Gly Gly Gly Gly  Ser Gly Gly Gly Gly  Ser Pro Lys 
    1595                 1600                 1605             


Lys Lys  Arg Lys Val 
    1610             


<210>  16
<211>  5145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg gccccgtggc ggtggacccc       60

accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt tcttcgaccc cagggagctc      120

cgcaaggaga cctgcctcct gtacgagatc aactggggcg gcaggcactc catctggagg      180

cacacgagcc agaacaccaa caagcacgtc gaggtgaact tcatcgagaa gttcaccacg      240

gagaggtact tctgcccgaa cacgcgctgc tccatcacgt ggttcctctc gtggagccca      300

tgcggcgagt gctccagggc gatcacggag ttcctcagcc gctacccgca cgtgaccctg      360

ttcatctaca tcgctaggct ctaccaccac gcggacccca ggaacaggca gggcctcagg      420

gacctgatct ccagcggcgt cacgatccag atcatgaccg agcaggagtc cggctactgc      480

tggaggaact tcgtgaacta ctccccgagc aacgaggccc actggccccg ctacccgcac      540

ctctgggtcc gcctctacgt gctcgagctg tactgcatca tcctcggcct gccgccctgc      600

ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct tcaccatcgc cctgcagagc      660

tgccactacc agaggctccc gccccacatc ctgtgggcga ccgggctcaa ggggggcggg      720

ggctcaggcg ggggcgggag cggcggcggg ggctctgggg gcggcggcag cggcgggggc      780

ggcagcgggg gcggcgggtc gatgagcaag ctggagaagt tcacgaactg ctactccctc      840

agcaagaccc tgaggttcaa ggcgatcccg gtcggcaaga cccaggagaa catcgacaac      900

aagcggctgc tggtggagga cgagaagagg gctgaggact acaagggcgt gaagaagctc      960

ctggaccgct actacctgtc cttcatcaac gacgtgctcc acagcatcaa gctcaagaac     1020

ctgaacaact acatcagcct cttcaggaag aagacgcgca ccgagaagga gaacaaggag     1080

ctcgagaacc tggagatcaa cctgaggaag gagatcgcca aggcgttcaa gggcaacgag     1140

ggctacaagt ccctcttcaa gaaggacatc atcgagacga tcctcccgga gttcctggac     1200

gacaaggacg agatcgccct ggtcaactcc ttcaacggct tcaccacggc gttcaccggc     1260

ttcttcgaca accgcgagaa catgttcagc gaggaggcca agtccacgag catcgcgttc     1320

aggtgcatca acgagaacct cacccgctac atctccaaca tggacatctt cgagaaggtc     1380

gacgcgatct tcgacaagca cgaggtgcag gagatcaagg agaagatcct gaacagcgac     1440

tacgacgtcg aggacttctt cgagggcgag ttcttcaact tcgtcctcac gcaggagggc     1500

atcgacgtgt acaacgccat catcggtggc ttcgtgaccg agtccggcga gaagatcaag     1560

ggcctgaacg agtacatcaa cctctacaac cagaagacca agcagaagct gccgaagttc     1620

aagcccctgt acaagcaggt gctctccgac agggagtccc tcagcttcta cggcgagggc     1680

tacacgagcg acgaggaggt cctggaggtg ttccgcaaca ccctcaacaa gaacagcgag     1740

atcttctcca gcatcaagaa gctcgagaag ctgttcaaga acttcgacga gtactccagc     1800

gccggcatct tcgtcaagaa cggcccggcg atctccacga tcagcaagga catcttcggc     1860

gagtggaacg tgatccgcga caagtggaac gccgagtacg acgacatcca cctcaagaag     1920

aaggcggtgg tcaccgagaa gtacgaggac gacaggcgca agtccttcaa gaagatcggc     1980

tccttcagcc tcgagcagct gcaggagtac gccgacgcgg acctgagcgt ggtcgagaag     2040

ctcaaggaga tcatcatcca gaaggtcgac gagatctaca aggtgtacgg ctccagcgag     2100

aagctcttcg acgcggactt cgtcctcgag aagtccctga agaagaacga cgccgtggtc     2160

gcgatcatga aggacctcct ggactccgtg aagagcttcg agaattacat caaggccttc     2220

ttcggcgagg gcaaggagac gaacagggac gagtccttct acggcgactt cgtcctggcc     2280

tacgacatcc tcctgaaggt ggaccacatc tacgacgcga tccgcaacta cgtgacccag     2340

aagccgtaca gcaaggacaa gttcaagctc tacttccaga acccccagtt catgggcggc     2400

tgggacaagg acaaggagac ggactacagg gcgaccatcc tgcgctacgg cagcaagtac     2460

tacctcgcca tcatggacaa gaagtacgcg aagtgcctgc agaagatcga caaggacgac     2520

gtcaacggca actacgagaa gatcaactac aagctcctgc cgggccccaa caagatgctc     2580

ccgaaggtgt tcttctccaa gaagtggatg gcctactaca accccagcga ggacatccag     2640

aagatctaca agaacggcac gttcaagaag ggcgacatgt tcaacctgaa cgactgccac     2700

aagctcatcg acttcttcaa ggactccatc agccgctacc cgaagtggtc caacgcctac     2760

gacttcaact tcagcgagac cgagaagtac aaggacatcg cgggcttcta ccgcgaggtc     2820

gaggagcagg gctacaaggt gtccttcgag tccgccagca agaaggaggt cgacaagctg     2880

gtggaggagg gcaagctcta catgttccag atctacaaca aggacttctc cgacaagagc     2940

cacggcacgc ccaacctgca caccatgtac ttcaagctcc tgttcgacga gaacaaccac     3000

ggccagatca ggctgtccgg cggcgccgag ctcttcatga ggagggcgag cctgaagaag     3060

gaggagctgg tggtccaccc cgctaacagc ccaatcgcga acaagaaccc ggacaacccc     3120

aagaagacca cgaccctgtc ctacgacgtg tacaaggaca agaggttcag cgaggaccag     3180

tacgagctcc acatcccgat cgcgatcaac aagtgcccca agaacatctt caagatcaac     3240

accgaggtcc gcgtgctcct gaagcacgac gacaacccct acgtgatcgg catcgctagg     3300

ggcgagagga acctcctgta catcgtggtc gtggacggca agggcaacat cgtggagcag     3360

tactccctca acgagatcat caacaacttc aacggcatca ggatcaagac ggactaccac     3420

agcctcctgg acaagaagga gaaggagagg ttcgaggccc gccagaactg gacctccatc     3480

gagaacatca aggagctgaa ggcgggctac atcagccagg tcgtgcacaa gatctgcgag     3540

ctcgtcgaga agtacgacgc cgtgatcgcc ctcgcggacc tgaactccgg cttcaagaac     3600

agccgcgtca aggtggagaa gcaggtctac cagaagttcg agaagatgct catcgacaag     3660

ctgaactaca tggtggacaa gaagtccaac ccctgcgcta cgggcggcgc gctgaagggc     3720

taccagatca ccaacaagtt cgagagcttc aagtccatga gcactcagaa cggcttcatc     3780

ttctacatcc cggcgtggct cacgtccaag atcgacccca gcaccggctt cgtcaacctc     3840

ctgaagacga agtacacctc catcgccgac agcaagaagt tcatctccag cttcgaccgc     3900

atcatgtatg tgccggagga ggacctgttc gagttcgccc tcgactacaa gaacttctcc     3960

cgcacggacg cggactacat caagaagtgg aagctgtaca gctacggcaa ccgcatccgc     4020

atcttcagga accccaagaa gaacaacgtc ttcgactggg aggaggtgtg cctgacctcc     4080

gcgtacaagg agctcttcaa caagtacggc atcaactacc agcagggcga catcagggct     4140

ctcctgtgcg agcagagcga caaggccttc tactccagct tcatggcgct gatgtccctc     4200

atgctgcaga tgaggaactc gatcaccggc aggacggacg tggccttcct catctccccg     4260

gtgaagaaca gcgacggcat cttctacgac tccaggaact acgaggccca ggagaacgcg     4320

atcctcccaa agaacgcgga cgccaacggc gcctacaaca tcgccaggaa ggtcctctgg     4380

gctatcggcc agttcaagaa ggcggaggac gagaagctgg acaaggtgaa gatcgccatc     4440

agcaacaagg agtggctcga gtacgcccag acctcggtca agcacggcag cccgaagaag     4500

aagcgcaagg tgggagggtc gacaggaggc ggttctggcg gaggttcagg tggaggctcg     4560

agtggtacga acctgtccga catcatcgag aaggagaccg gcaagcagct cgtgatccag     4620

gagagcatcc tcatgctgcc ggaggaggtc gaggaggtca tcggcaacaa gcccgagtcc     4680

gacatcctcg tccacacggc ctacgacgag tccaccgacg agaacgtgat gctcctgacc     4740

tcggacgctc ccgagtacaa gccatgggcc ctggtcatcc aggacagcaa cggcgagaac     4800

aagatcaaga tgctcggtgg aggcggttca ggcggaggtg gctctggcgg tggcggatcg     4860

acgaacctgt ccgacatcat cgagaaggag accggcaagc agctcgtgat ccaggagagc     4920

atcctcatgc tgccggagga ggtcgaggag gtcatcggca acaagcccga gtccgacatc     4980

ctcgtccaca cggcctacga cgagtccacc gacgagaacg tgatgctcct gacctcggac     5040

gctcccgagt acaagccatg ggccctggtc atccaggaca gcaacggcga gaacaagatc     5100

aagatgctct ccggcggcag cccgaagaag aagcgcaaag tgtga                     5145


<210>  17
<211>  1714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Pro Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val 
1               5                   10                  15      


Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu 
            20                  25                  30          


Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr 
        35                  40                  45              


Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln 
    50                  55                  60                  


Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr 
65                  70                  75                  80  


Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu 
                85                  90                  95      


Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu 
            100                 105                 110         


Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr 
        115                 120                 125             


His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser 
    130                 135                 140                 


Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys 
145                 150                 155                 160 


Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro 
                165                 170                 175     


Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys 
            180                 185                 190         


Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln 
        195                 200                 205             


Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln 
    210                 215                 220                 


Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Lys Leu Glu 
            260                 265                 270         


Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala 
        275                 280                 285             


Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu 
    290                 295                 300                 


Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu 
305                 310                 315                 320 


Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile 
                325                 330                 335     


Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr 
            340                 345                 350         


Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu 
        355                 360                 365             


Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser 
    370                 375                 380                 


Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp 
385                 390                 395                 400 


Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr 
                405                 410                 415     


Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu 
            420                 425                 430         


Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr 
        435                 440                 445             


Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe 
    450                 455                 460                 


Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp 
465                 470                 475                 480 


Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu 
                485                 490                 495     


Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val 
            500                 505                 510         


Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu 
        515                 520                 525             


Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr 
    530                 535                 540                 


Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly 
545                 550                 555                 560 


Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn 
                565                 570                 575     


Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe 
            580                 585                 590         


Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly 
        595                 600                 605             


Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val 
    610                 615                 620                 


Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys 
625                 630                 635                 640 


Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe 
                645                 650                 655     


Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp 
            660                 665                 670         


Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys 
        675                 680                 685             


Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp 
    690                 695                 700                 


Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val 
705                 710                 715                 720 


Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr 
                725                 730                 735     


Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser 
            740                 745                 750         


Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp 
        755                 760                 765             


His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser 
    770                 775                 780                 


Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly 
785                 790                 795                 800 


Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr 
                805                 810                 815     


Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys 
            820                 825                 830         


Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile 
        835                 840                 845             


Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe 
    850                 855                 860                 


Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln 
865                 870                 875                 880 


Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu 
                885                 890                 895     


Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg 
            900                 905                 910         


Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu 
        915                 920                 925             


Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly 
    930                 935                 940                 


Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu 
945                 950                 955                 960 


Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe 
                965                 970                 975     


Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys 
            980                 985                 990         


Leu Leu Phe Asp Glu Asn Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly 
        995                 1000                 1005             


Ala Glu  Leu Phe Met Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu 
    1010                 1015                 1020             


Val Val  His Pro Ala Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp 
    1025                 1030                 1035             


Asn Pro  Lys Lys Thr Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp 
    1040                 1045                 1050             


Lys Arg  Phe Ser Glu Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala 
    1055                 1060                 1065             


Ile Asn  Lys Cys Pro Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val 
    1070                 1075                 1080             


Arg Val  Leu Leu Lys His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile 
    1085                 1090                 1095             


Ala Arg  Gly Glu Arg Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly 
    1100                 1105                 1110             


Lys Gly  Asn Ile Val Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn 
    1115                 1120                 1125             


Asn Phe  Asn Gly Ile Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu 
    1130                 1135                 1140             


Asp Lys  Lys Glu Lys Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr 
    1145                 1150                 1155             


Ser Ile  Glu Asn Ile Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln 
    1160                 1165                 1170             


Val Val  His Lys Ile Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val 
    1175                 1180                 1185             


Ile Ala  Leu Ala Asp Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val 
    1190                 1195                 1200             


Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile 
    1205                 1210                 1215             


Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala 
    1220                 1225                 1230             


Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu 
    1235                 1240                 1245             


Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile 
    1250                 1255                 1260             


Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val 
    1265                 1270                 1275             


Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys 
    1280                 1285                 1290             


Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp 
    1295                 1300                 1305             


Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp 
    1310                 1315                 1320             


Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg 
    1325                 1330                 1335             


Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp 
    1340                 1345                 1350             


Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys 
    1355                 1360                 1365             


Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys 
    1370                 1375                 1380             


Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met 
    1385                 1390                 1395             


Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile Thr Gly  Arg Thr Asp 
    1400                 1405                 1410             


Val Ala  Phe Leu Ile Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe 
    1415                 1420                 1425             


Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro 
    1430                 1435                 1440             


Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val 
    1445                 1450                 1455             


Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu 
    1460                 1465                 1470             


Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr 
    1475                 1480                 1485             


Ala Gln  Thr Ser Val Lys His  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1490                 1495                 1500             


Val Gly  Gly Ser Thr Gly Gly  Gly Ser Gly Gly Gly  Ser Gly Gly 
    1505                 1510                 1515             


Gly Ser  Ser Gly Thr Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr 
    1520                 1525                 1530             


Gly Lys  Gln Leu Val Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu 
    1535                 1540                 1545             


Glu Val  Glu Glu Val Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu 
    1550                 1555                 1560             


Val His  Thr Ala Tyr Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu 
    1565                 1570                 1575             


Leu Thr  Ser Asp Ala Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile 
    1580                 1585                 1590             


Gln Asp  Ser Asn Gly Glu Asn  Lys Ile Lys Met Leu  Gly Gly Gly 
    1595                 1600                 1605             


Gly Ser  Gly Gly Gly Gly Ser  Gly Gly Gly Gly Ser  Thr Asn Leu 
    1610                 1615                 1620             


Ser Asp  Ile Ile Glu Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln 
    1625                 1630                 1635             


Glu Ser  Ile Leu Met Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly 
    1640                 1645                 1650             


Asn Lys  Pro Glu Ser Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu 
    1655                 1660                 1665             


Ser Thr  Asp Glu Asn Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu 
    1670                 1675                 1680             


Tyr Lys  Pro Trp Ala Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn 
    1685                 1690                 1695             


Lys Ile  Lys Met Leu Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1700                 1705                 1710             


Val 
    


<210>  18
<211>  4767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg gccccgtggc ggtggacccc       60

accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt tcttcgaccc cagggagctc      120

cgcaaggaga cctgcctcct gtacgagatc aactggggcg gcaggcactc catctggagg      180

cacacgagcc agaacaccaa caagcacgtc gaggtgaact tcatcgagaa gttcaccacg      240

gagaggtact tctgcccgaa cacgcgctgc tccatcacgt ggttcctctc gtggagccca      300

tgcggcgagt gctccagggc gatcacggag ttcctcagcc gctacccgca cgtgaccctg      360

ttcatctaca tcgctaggct ctaccaccac gcggacccca ggaacaggca gggcctcagg      420

gacctgatct ccagcggcgt cacgatccag atcatgaccg agcaggagtc cggctactgc      480

tggaggaact tcgtgaacta ctccccgagc aacgaggccc actggccccg ctacccgcac      540

ctctgggtcc gcctctacgt gctcgagctg tactgcatca tcctcggcct gccgccctgc      600

ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct tcaccatcgc cctgcagagc      660

tgccactacc agaggctccc gccccacatc ctgtgggcga ccgggctcaa gtcgggcagc      720

gagacccccg gcacctccga gtcggctacc ccagagtcca tgagcaagct ggagaagttc      780

acgaactgct actccctcag caagaccctg aggttcaagg cgatcccggt cggcaagacc      840

caggagaaca tcgacaacaa gcggctgctg gtggaggacg agaagagggc tgaggactac      900

aagggcgtga agaagctcct ggaccgctac tacctgtcct tcatcaacga cgtgctccac      960

agcatcaagc tcaagaacct gaacaactac atcagcctct tcaggaagaa gacgcgcacc     1020

gagaaggaga acaaggagct cgagaacctg gagatcaacc tgaggaagga gatcgccaag     1080

gcgttcaagg gcaacgaggg ctacaagtcc ctcttcaaga aggacatcat cgagacgatc     1140

ctcccggagt tcctggacga caaggacgag atcgccctgg tcaactcctt caacggcttc     1200

accacggcgt tcaccggctt cttcgacaac cgcgagaaca tgttcagcga ggaggccaag     1260

tccacgagca tcgcgttcag gtgcatcaac gagaacctca cccgctacat ctccaacatg     1320

gacatcttcg agaaggtcga cgcgatcttc gacaagcacg aggtgcagga gatcaaggag     1380

aagatcctga acagcgacta cgacgtcgag gacttcttcg agggcgagtt cttcaacttc     1440

gtcctcacgc aggagggcat cgacgtgtac aacgccatca tcggtggctt cgtgaccgag     1500

tccggcgaga agatcaaggg cctgaacgag tacatcaacc tctacaacca gaagaccaag     1560

cagaagctgc cgaagttcaa gcccctgtac aagcaggtgc tctccgacag ggagtccctc     1620

agcttctacg gcgagggcta cacgagcgac gaggaggtcc tggaggtgtt ccgcaacacc     1680

ctcaacaaga acagcgagat cttctccagc atcaagaagc tcgagaagct gttcaagaac     1740

ttcgacgagt actccagcgc cggcatcttc gtcaagaacg gcccggcgat ctccacgatc     1800

agcaaggaca tcttcggcga gtggaacgtg atccgcgaca agtggaacgc cgagtacgac     1860

gacatccacc tcaagaagaa ggcggtggtc accgagaagt acgaggacga caggcgcaag     1920

tccttcaaga agatcggctc cttcagcctc gagcagctgc aggagtacgc cgacgcggac     1980

ctgagcgtgg tcgagaagct caaggagatc atcatccaga aggtcgacga gatctacaag     2040

gtgtacggct ccagcgagaa gctcttcgac gcggacttcg tcctcgagaa gtccctgaag     2100

aagaacgacg ccgtggtcgc gatcatgaag gacctcctgg actccgtgaa gagcttcgag     2160

aattacatca aggccttctt cggcgagggc aaggagacga acagggacga gtccttctac     2220

ggcgacttcg tcctggccta cgacatcctc ctgaaggtgg accacatcta cgacgcgatc     2280

cgcaactacg tgacccagaa gccgtacagc aaggacaagt tcaagctcta cttccagaac     2340

ccccagttca tgggcggctg ggacaaggac aaggagacgg actacagggc gaccatcctg     2400

cgctacggca gcaagtacta cctcgccatc atggacaaga agtacgcgaa gtgcctgcag     2460

aagatcgaca aggacgacgt caacggcaac tacgagaaga tcaactacaa gctcctgccg     2520

ggccccaaca agatgctccc gaaggtgttc ttctccaaga agtggatggc ctactacaac     2580

cccagcgagg acatccagaa gatctacaag aacggcacgt tcaagaaggg cgacatgttc     2640

aacctgaacg actgccacaa gctcatcgac ttcttcaagg actccatcag ccgctacccg     2700

aagtggtcca acgcctacga cttcaacttc agcgagaccg agaagtacaa ggacatcgcg     2760

ggcttctacc gcgaggtcga ggagcagggc tacaaggtgt ccttcgagtc cgccagcaag     2820

aaggaggtcg acaagctggt ggaggagggc aagctctaca tgttccagat ctacaacaag     2880

gacttctccg acaagagcca cggcacgccc aacctgcaca ccatgtactt caagctcctg     2940

ttcgacgaga acaaccacgg ccagatcagg ctgtccggcg gcgccgagct cttcatgagg     3000

agggcgagcc tgaagaagga ggagctggtg gtccaccccg ctaacagccc aatcgcgaac     3060

aagaacccgg acaaccccaa gaagaccacg accctgtcct acgacgtgta caaggacaag     3120

aggttcagcg aggaccagta cgagctccac atcccgatcg cgatcaacaa gtgccccaag     3180

aacatcttca agatcaacac cgaggtccgc gtgctcctga agcacgacga caacccctac     3240

gtgatcggca tcgctagggg cgagaggaac ctcctgtaca tcgtggtcgt ggacggcaag     3300

ggcaacatcg tggagcagta ctccctcaac gagatcatca acaacttcaa cggcatcagg     3360

atcaagacgg actaccacag cctcctggac aagaaggaga aggagaggtt cgaggcccgc     3420

cagaactgga cctccatcga gaacatcaag gagctgaagg cgggctacat cagccaggtc     3480

gtgcacaaga tctgcgagct cgtcgagaag tacgacgccg tgatcgccct cgcggacctg     3540

aactccggct tcaagaacag ccgcgtcaag gtggagaagc aggtctacca gaagttcgag     3600

aagatgctca tcgacaagct gaactacatg gtggacaaga agtccaaccc ctgcgctacg     3660

ggcggcgcgc tgaagggcta ccagatcacc aacaagttcg agagcttcaa gtccatgagc     3720

actcagaacg gcttcatctt ctacatcccg gcgtggctca cgtccaagat cgaccccagc     3780

accggcttcg tcaacctcct gaagacgaag tacacctcca tcgccgacag caagaagttc     3840

atctccagct tcgaccgcat catgtatgtg ccggaggagg acctgttcga gttcgccctc     3900

gactacaaga acttctcccg cacggacgcg gactacatca agaagtggaa gctgtacagc     3960

tacggcaacc gcatccgcat cttcaggaac cccaagaaga acaacgtctt cgactgggag     4020

gaggtgtgcc tgacctccgc gtacaaggag ctcttcaaca agtacggcat caactaccag     4080

cagggcgaca tcagggctct cctgtgcgag cagagcgaca aggccttcta ctccagcttc     4140

atggcgctga tgtccctcat gctgcagatg aggaactcga tcaccggcag gacggacgtg     4200

gccttcctca tctccccggt gaagaacagc gacggcatct tctacgactc caggaactac     4260

gaggcccagg agaacgcgat cctcccaaag aacgcggacg ccaacggcgc ctacaacatc     4320

gccaggaagg tcctctgggc tatcggccag ttcaagaagg cggaggacga gaagctggac     4380

aaggtgaaga tcgccatcag caacaaggag tggctcgagt acgcccagac ctcggtcaag     4440

cacggcagcc cgaagaagaa gcgcaaggtg tccggcggca gcacgaacct gtccgacatc     4500

atcgagaagg agaccggcaa gcagctcgtg atccaggaga gcatcctcat gctgccggag     4560

gaggtcgagg aggtcatcgg caacaagccc gagtccgaca tcctcgtcca cacggcctac     4620

gacgagtcca ccgacgagaa cgtgatgctc ctgacctcgg acgctcccga gtacaagcca     4680

tgggccctgg tcatccagga cagcaacggc gagaacaaga tcaagatgct ctccggcggc     4740

agcccgaaga agaagcgcaa agtgtga                                         4767


<210>  19
<211>  1588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Pro Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val 
1               5                   10                  15      


Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu 
            20                  25                  30          


Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr 
        35                  40                  45              


Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln 
    50                  55                  60                  


Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr 
65                  70                  75                  80  


Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu 
                85                  90                  95      


Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu 
            100                 105                 110         


Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr 
        115                 120                 125             


His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser 
    130                 135                 140                 


Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys 
145                 150                 155                 160 


Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro 
                165                 170                 175     


Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys 
            180                 185                 190         


Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln 
        195                 200                 205             


Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln 
    210                 215                 220                 


Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser Gly Ser 
225                 230                 235                 240 


Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met Ser Lys 
                245                 250                 255     


Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe 
            260                 265                 270         


Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg 
        275                 280                 285             


Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys 
    290                 295                 300                 


Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His 
305                 310                 315                 320 


Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys 
                325                 330                 335     


Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile 
            340                 345                 350         


Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr 
        355                 360                 365             


Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe 
    370                 375                 380                 


Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe 
385                 390                 395                 400 


Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser 
                405                 410                 415     


Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn 
            420                 425                 430         


Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala 
        435                 440                 445             


Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn 
    450                 455                 460                 


Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe 
465                 470                 475                 480 


Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly 
                485                 490                 495     


Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile 
            500                 505                 510         


Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro 
        515                 520                 525             


Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly 
    530                 535                 540                 


Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr 
545                 550                 555                 560 


Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys 
                565                 570                 575     


Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys 
            580                 585                 590         


Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp 
        595                 600                 605             


Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu 
    610                 615                 620                 


Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys 
625                 630                 635                 640 


Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr 
                645                 650                 655     


Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile 
            660                 665                 670         


Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu 
        675                 680                 685             


Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala 
    690                 695                 700                 


Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu 
705                 710                 715                 720 


Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp 
                725                 730                 735     


Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys 
            740                 745                 750         


Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro 
        755                 760                 765             


Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met 
    770                 775                 780                 


Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu 
785                 790                 795                 800 


Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala 
                805                 810                 815     


Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu 
            820                 825                 830         


Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys 
        835                 840                 845             


Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp 
    850                 855                 860                 


Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe 
865                 870                 875                 880 


Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile 
                885                 890                 895     


Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu 
            900                 905                 910         


Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu 
        915                 920                 925             


Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp 
    930                 935                 940                 


Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys 
945                 950                 955                 960 


Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr 
                965                 970                 975     


Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg Leu Ser 
            980                 985                 990         


Gly Gly Ala Glu Leu Phe Met Arg  Arg Ala Ser Leu Lys  Lys Glu Glu 
        995                 1000                 1005             


Leu Val  Val His Pro Ala Asn  Ser Pro Ile Ala Asn  Lys Asn Pro 
    1010                 1015                 1020             


Asp Asn  Pro Lys Lys Thr Thr  Thr Leu Ser Tyr Asp  Val Tyr Lys 
    1025                 1030                 1035             


Asp Lys  Arg Phe Ser Glu Asp  Gln Tyr Glu Leu His  Ile Pro Ile 
    1040                 1045                 1050             


Ala Ile  Asn Lys Cys Pro Lys  Asn Ile Phe Lys Ile  Asn Thr Glu 
    1055                 1060                 1065             


Val Arg  Val Leu Leu Lys His  Asp Asp Asn Pro Tyr  Val Ile Gly 
    1070                 1075                 1080             


Ile Ala  Arg Gly Glu Arg Asn  Leu Leu Tyr Ile Val  Val Val Asp 
    1085                 1090                 1095             


Gly Lys  Gly Asn Ile Val Glu  Gln Tyr Ser Leu Asn  Glu Ile Ile 
    1100                 1105                 1110             


Asn Asn  Phe Asn Gly Ile Arg  Ile Lys Thr Asp Tyr  His Ser Leu 
    1115                 1120                 1125             


Leu Asp  Lys Lys Glu Lys Glu  Arg Phe Glu Ala Arg  Gln Asn Trp 
    1130                 1135                 1140             


Thr Ser  Ile Glu Asn Ile Lys  Glu Leu Lys Ala Gly  Tyr Ile Ser 
    1145                 1150                 1155             


Gln Val  Val His Lys Ile Cys  Glu Leu Val Glu Lys  Tyr Asp Ala 
    1160                 1165                 1170             


Val Ile  Ala Leu Ala Asp Leu  Asn Ser Gly Phe Lys  Asn Ser Arg 
    1175                 1180                 1185             


Val Lys  Val Glu Lys Gln Val  Tyr Gln Lys Phe Glu  Lys Met Leu 
    1190                 1195                 1200             


Ile Asp  Lys Leu Asn Tyr Met  Val Asp Lys Lys Ser  Asn Pro Cys 
    1205                 1210                 1215             


Ala Thr  Gly Gly Ala Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe 
    1220                 1225                 1230             


Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr 
    1235                 1240                 1245             


Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe 
    1250                 1255                 1260             


Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys 
    1265                 1270                 1275             


Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu 
    1280                 1285                 1290             


Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr 
    1295                 1300                 1305             


Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn 
    1310                 1315                 1320             


Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp 
    1325                 1330                 1335             


Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn 
    1340                 1345                 1350             


Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu 
    1355                 1360                 1365             


Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu 
    1370                 1375                 1380             


Met Ser  Leu Met Leu Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr 
    1385                 1390                 1395             


Asp Val  Ala Phe Leu Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile 
    1400                 1405                 1410             


Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu 
    1415                 1420                 1425             


Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1430                 1435                 1440             


Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys 
    1445                 1450                 1455             


Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu 
    1460                 1465                 1470             


Tyr Ala  Gln Thr Ser Val Lys  His Gly Ser Pro Lys  Lys Lys Arg 
    1475                 1480                 1485             


Lys Val  Ser Gly Gly Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys 
    1490                 1495                 1500             


Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu 
    1505                 1510                 1515             


Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp 
    1520                 1525                 1530             


Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val 
    1535                 1540                 1545             


Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu 
    1550                 1555                 1560             


Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser 
    1565                 1570                 1575             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1580                 1585             


<210>  20
<211>  5229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
atgccgaaga agaagcgcaa ggtgtccagc gagaccggcc ccgtggcggt cgaccccacc       60

ctgcgcaggc gcatcgagcc gcacgagttc gaggtcttct tcgaccccag ggagctccgc      120

aaggagacct gcctcctgta cgagatcaac tggggcggca ggcactccat ctggaggcac      180

accagccaga acacgaacaa gcacgtggag gtcaacttca tcgagaagtt caccacggag      240

aggtacttct gcccgaacac ccgctgctcc atcacctggt tcctctcgtg gagcccatgc      300

ggcgagtgct ccagggcgat cacggagttc ctcagccgct acccgcacgt gaccctcttc      360

atctacatcg ctaggctgta ccaccacgcg gaccccagga acaggcaggg gctcagggac      420

ctgatctcca gcggcgtgac catccagatc atgacggagc aggagtccgg ctactgctgg      480

cgcaacttcg tcaactactc cccgagcaac gaggcccact ggccccgcta cccgcacctg      540

tgggtgcgcc tctacgtcct cgagctgtac tgcatcatcc tcggcctgcc gccctgcctc      600

aacatcctga ggcgcaagca gccccagctc accttcttca cgatcgccct gcagagctgc      660

cactaccagc ggctgccgcc ccacatcctc tgggccaccg gcctgaagtc gggcagcgag      720

acgcccggca cgtccgagtc ggctacccca gagctcaagg acaagaagta cagcatcggc      780

ctggcaatcg gcaccaacag cgtgggctgg gccgtgatca ccgacgagta caaggtgccg      840

agcaagaagt tcaaggtgct gggcaacacc gacaggcaca gcatcaagaa gaacctgatc      900

ggcgccctgc tgttcgacag cggcgagacc gccgaggcca ccaggctgaa gaggaccgcc      960

aggaggaggt acaccaggag gaagaacagg atctgctacc tgcaggagat cttcagcaac     1020

gagatggcca aggtggacga cagcttcttc cacaggctgg aggagagctt cctggtggag     1080

gaggacaaga agcacgagag gcacccgatc ttcggcaaca tcgtggacga ggtggcctac     1140

cacgagaagt acccgaccat ctaccacctg aggaagaagc tggtggacag caccgacaag     1200

gccgacctga ggctgatcta cctggccctg gcccacatga tcaagttcag gggccacttc     1260

ctgatcgagg gcgacctgaa cccggacaac agcgacgtgg acaagctgtt catccagctg     1320

gtgcagacct acaaccagct gttcgaggag aacccgatca acgccagcgg cgtggacgcc     1380

aaggccatcc tgagcgccag gctgagcaag agcaggaggc tggagaacct gatcgcccag     1440

ctgccgggcg agaagaagaa cggcctgttc ggcaacctga tcgccctgag cctgggcctg     1500

accccgaact tcaagagcaa cttcgacctg gccgaggacg ccaagctgca gctgagcaag     1560

gacacctacg acgacgacct ggacaacctg ctggcccaga tcggcgacca gtacgccgac     1620

ctgttcctgg ccgccaagaa cctgagcgac gccatcctgc tgagcgacat cctgagggtg     1680

aacaccgaga tcaccaaggc cccgctgagc gccagcatga tcaagaggta cgacgagcac     1740

caccaggacc tgaccctgct gaaggccctg gtgaggcagc agctgccgga gaagtacaag     1800

gagatcttct tcgaccagag caagaacggc tacgccggct acatcgacgg cggcgccagc     1860

caggaggagt tctacaagtt catcaagccg atcctggaga agatggacgg caccgaggag     1920

ctgctggtga agctgaacag ggaggacctg ctgaggaagc agaggacctt cgacaacggc     1980

agcatcccgc accagatcca cctgggcgag ctgcacgcca tcctgaggag gcaggaggac     2040

ttctacccgt tcctgaagga caacagggag aagatcgaga agatcctgac cttccgcatc     2100

ccgtactacg tgggcccgct ggccaggggc aacagcaggt tcgcctggat gaccaggaag     2160

agcgaggaga ccatcacccc gtggaacttc gaggaggtgg tggacaaggg cgccagcgcc     2220

cagagcttca tcgagaggat gaccaacttc gacaagaacc tgccgaacga gaaggtgctg     2280

ccgaagcaca gcctgctgta cgagtacttc accgtgtaca acgagctgac caaggtgaag     2340

tacgtgaccg agggcatgag gaagccggcc ttcctgagcg gcgagcagaa gaaggccatc     2400

gtggacctgc tgttcaagac caacaggaag gtgaccgtga agcagctgaa ggaggactac     2460

ttcaagaaga tcgagtgctt cgacagcgtg gagatcagcg gcgtggagga caggttcaac     2520

gccagcctgg gcacctacca cgacctgctg aagatcatca aggacaagga cttcctggac     2580

aacgaggaga acgaggacat cctggaggac atcgtgctga ccctgaccct gttcgaggac     2640

agggagatga tcgaggagag gctgaagacc tacgcccacc tgttcgacga caaggtgatg     2700

aagcagctga agaggaggag gtacaccggc tggggcaggc tgagcaggaa gctgatcaac     2760

ggcatcaggg acaagcagag cggcaagacc atcctggact tcctgaagag cgacggcttc     2820

gccaacagga acttcatgca gctgatccac gacgacagcc tgaccttcaa ggaggacatc     2880

cagaaggccc aggtgagcgg ccagggcgac agcctgcacg agcacatcgc caacctggcc     2940

ggcagcccgg ccatcaagaa gggcatcctg cagaccgtga aggtggtgga cgagctggtg     3000

aaggtgatgg gcaggcacaa gccggagaac atcgtgatcg agatggccag ggagaaccag     3060

accacccaga agggccagaa gaacagcagg gagaggatga agaggatcga ggagggcatc     3120

aaggagctgg gcagccagat cctgaaggag cacccggtgg agaacaccca gctgcagaac     3180

gagaagctgt acctgtacta cctgcagaac ggcagggaca tgtacgtgga ccaggagctg     3240

gacatcaaca ggctgagcga ctacgacgtg gaccacatcg tgccgcagag cttcctgaag     3300

gacgacagca tcgacaacaa ggtgctgacc aggagcgaca agaacagggg caagagcgac     3360

aacgtgccga gcgaggaggt ggtgaagaag atgaaaaact actggaggca gctgctgaac     3420

gccaagctga tcacccagag gaagttcgac aacctgacca aggccgagag gggcggcctg     3480

agcgagctgg acaaggccgg cttcattaaa aggcagctgg tggagaccag gcagatcacc     3540

aagcacgtgg cccagatcct ggacagcagg atgaacacca agtacgacga gaacgacaag     3600

ctgatcaggg aggtgaaggt gatcaccctg aagagcaagc tggtgagcga cttcaggaag     3660

gacttccagt tctacaaggt gagggagatc aataattacc accacgccca cgacgcctac     3720

ctgaacgccg tggtgggcac cgccctgatt aaaaagtacc cgaagctgga gagcgagttc     3780

gtgtacggcg actacaaggt gtacgacgtg aggaagatga tcgccaagag cgagcaggag     3840

atcggcaagg ccaccgccaa gtacttcttc tacagcaaca tcatgaactt cttcaagacc     3900

gagatcaccc tggccaacgg cgagatcagg aagaggccgc tgatcgagac caacggcgag     3960

accggcgaga tcgtgtggga caagggcagg gacttcgcca ccgtgaggaa ggtgctgtcc     4020

atgccgcagg tgaacatcgt gaagaagacc gaggtgcaga ccggcggctt cagcaaggag     4080

agcatcctgc cgaagaggaa cagcgacaag ctgatcgcca ggaagaagga ctgggatccg     4140

aagaagtacg gcggcttcga cagcccgacc gtggcctaca gcgtgctggt ggtggccaag     4200

gtggagaagg gcaagagcaa gaagctgaag agcgtgaagg agctggtggg catcaccatc     4260

atggagagga gcagcttcga gaagaaccca gtggacttcc tggaggccaa gggctacaag     4320

gaggtgaaga aggacctgat cattaaactg ccgaagtaca gcctgttcga gctggagaac     4380

ggcaggaaga ggatgctggc cagcgccggc gagctgcaga agggcaacga gctggccctg     4440

ccgagcaagt acgtgaactt cctgtacctg gccagccact acgagaagct gaagggcagc     4500

ccggaggaca acgagcagaa gcagctgttc gtggagcagc acaagcacta cctggacgag     4560

atcatcgagc agatcagcga gttcagcaag agggtgatcc tggccgacgc caacctggac     4620

aaggtgctga gcgcctacaa caagcacagg gacaagccga tcagggagca ggccgagaac     4680

atcatccacc tgttcaccct gaccaacctg ggcgccccgg ccgccttcaa gtacttcgac     4740

accaccatcg acaggaagag gtacaccagc accaaggagg tgctggacgc caccctgatc     4800

caccagagca tcaccggcct gtacgagacc aggatcgacc tgagccagct gggcggcgac     4860

agcagcccgc cgaagaagaa gaggaaggtg agctggaagg acgccagcgg ctggagcagg     4920

atgaccaggg actccggcgg cagcaccaac ctctccgaca tcatcgagaa ggagacgggc     4980

aagcagctcg tgatccagga gagcatcctc atgctgccgg aggaggtgga ggaggtcatc     5040

ggcaacaagc ccgagtccga catcctcgtg cacacggcct acgacgagtc caccgacgag     5100

aacgtcatgc tcctgacctc ggacgctccc gagtacaagc catgggccct cgtgatccag     5160

gacagcaacg gcgagaacaa gatcaagatg ctctccggcg gcagcccgaa gaagaagcgc     5220

aaagtctga                                                             5229


<210>  21
<211>  1742
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Pro Lys Lys Lys Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala 
1               5                   10                  15      


Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val 
            20                  25                  30          


Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu 
        35                  40                  45              


Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln Asn 
    50                  55                  60                  


Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu 
65                  70                  75                  80  


Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser 
                85                  90                  95      


Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser 
            100                 105                 110         


Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His 
        115                 120                 125             


His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser 
    130                 135                 140                 


Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp 
145                 150                 155                 160 


Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg 
                165                 170                 175     


Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile 
            180                 185                 190         


Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro 
        195                 200                 205             


Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg 
    210                 215                 220                 


Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Leu Lys Asp Lys Lys 
                245                 250                 255     


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
            260                 265                 270         


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
        275                 280                 285             


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
    290                 295                 300                 


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
305                 310                 315                 320 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
                325                 330                 335     


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
            340                 345                 350         


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
        355                 360                 365             


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
    370                 375                 380                 


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
385                 390                 395                 400 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
                405                 410                 415     


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
            420                 425                 430         


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
        435                 440                 445             


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
    450                 455                 460                 


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
465                 470                 475                 480 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
                485                 490                 495     


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
            500                 505                 510         


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
        515                 520                 525             


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
    530                 535                 540                 


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
545                 550                 555                 560 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
                565                 570                 575     


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
            580                 585                 590         


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
        595                 600                 605             


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
    610                 615                 620                 


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
625                 630                 635                 640 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
                645                 650                 655     


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
            660                 665                 670         


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
        675                 680                 685             


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
    690                 695                 700                 


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
705                 710                 715                 720 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
                725                 730                 735     


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
            740                 745                 750         


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
        755                 760                 765             


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
    770                 775                 780                 


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
785                 790                 795                 800 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
                805                 810                 815     


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
            820                 825                 830         


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
        835                 840                 845             


Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn 
    850                 855                 860                 


Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp 
865                 870                 875                 880 


Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp 
                885                 890                 895     


Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly 
            900                 905                 910         


Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly 
        915                 920                 925             


Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn 
    930                 935                 940                 


Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile 
945                 950                 955                 960 


Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile 
                965                 970                 975     


Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr 
            980                 985                 990         


Val Lys Val Val Asp Glu Leu Val  Lys Val Met Gly Arg  His Lys Pro 
        995                 1000                 1005             


Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln 
    1010                 1015                 1020             


Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu 
    1025                 1030                 1035             


Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu Lys Glu  His Pro Val 
    1040                 1045                 1050             


Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu 
    1055                 1060                 1065             


Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn 
    1070                 1075                 1080             


Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile Val Pro  Gln Ser Phe 
    1085                 1090                 1095             


Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp 
    1100                 1105                 1110             


Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro Ser Glu  Glu Val Val 
    1115                 1120                 1125             


Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu 
    1130                 1135                 1140             


Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly 
    1145                 1150                 1155             


Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
    1160                 1165                 1170             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1175                 1180                 1185             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1190                 1195                 1200             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1205                 1210                 1215             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1220                 1225                 1230             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1235                 1240                 1245             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1250                 1255                 1260             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1265                 1270                 1275             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1280                 1285                 1290             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1295                 1300                 1305             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1310                 1315                 1320             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1325                 1330                 1335             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1340                 1345                 1350             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1355                 1360                 1365             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1370                 1375                 1380             


Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1385                 1390                 1395             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1400                 1405                 1410             


Glu Leu  Val Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1415                 1420                 1425             


Asn Pro  Val Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1430                 1435                 1440             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1445                 1450                 1455             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1460                 1465                 1470             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1475                 1480                 1485             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1490                 1495                 1500             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1505                 1510                 1515             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1520                 1525                 1530             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1535                 1540                 1545             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1550                 1555                 1560             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1565                 1570                 1575             


Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu 
    1580                 1585                 1590             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1595                 1600                 1605             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Ser Ser Pro 
    1610                 1615                 1620             


Pro Lys  Lys Lys Arg Lys Val  Ser Trp Lys Asp Ala  Ser Gly Trp 
    1625                 1630                 1635             


Ser Arg  Met Thr Arg Asp Ser  Gly Gly Ser Thr Asn  Leu Ser Asp 
    1640                 1645                 1650             


Ile Ile  Glu Lys Glu Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser 
    1655                 1660                 1665             


Ile Leu  Met Leu Pro Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys 
    1670                 1675                 1680             


Pro Glu  Ser Asp Ile Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr 
    1685                 1690                 1695             


Asp Glu  Asn Val Met Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys 
    1700                 1705                 1710             


Pro Trp  Ala Leu Val Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile 
    1715                 1720                 1725             


Lys Met  Leu Ser Gly Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1730                 1735                 1740         


<210>  22
<211>  1316
<212>  PRT
<213>  Acidaminococcus fermentans

<400>  22

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Ala Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Ala Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Ala  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn Gly 
    1295                 1300                 1305             


Ser Pro  Lys Lys Lys Arg Lys  Val 
    1310                 1315     


<210>  23
<211>  4809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon Optimized

<400>  23
atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg gccccgtggc ggtggacccc       60

accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt tcttcgaccc cagggagctc      120

cgcaaggaga cctgcctcct gtacgagatc aactggggcg gcaggcactc catctggagg      180

cacacgagcc agaacaccaa caagcacgtc gaggtgaact tcatcgagaa gttcaccacg      240

gagaggtact tctgcccgaa cacgcgctgc tccatcacgt ggttcctctc gtggagccca      300

tgcggcgagt gctccagggc gatcacggag ttcctcagcc gctacccgca cgtgaccctg      360

ttcatctaca tcgctaggct ctaccaccac gcggacccca ggaacaggca gggcctcagg      420

gacctgatct ccagcggcgt cacgatccag atcatgaccg agcaggagtc cggctactgc      480

tggaggaact tcgtgaacta ctccccgagc aacgaggccc actggccccg ctacccgcac      540

ctctgggtcc gcctctacgt gctcgagctg tactgcatca tcctcggcct gccgccctgc      600

ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct tcaccatcgc cctgcagagc      660

tgccactacc agaggctccc gccccacatc ctgtgggcga ccgggctcaa ggggggcggg      720

ggctcaggcg ggggcgggag cggcggcggg ggctctgggg gcggcggcag cggcgggggc      780

ggcagcgggg gcggcgggtc gatgagcaag ctggagaagt tcacgaactg ctactccctc      840

agcaagaccc tgaggttcaa ggcgatcccg gtcggcaaga cccaggagaa catcgacaac      900

aagcggctgc tggtggagga cgagaagagg gctgaggact acaagggcgt gaagaagctc      960

ctggaccgct actacctgtc cttcatcaac gacgtgctcc acagcatcaa gctcaagaac     1020

ctgaacaact acatcagcct cttcaggaag aagacgcgca ccgagaagga gaacaaggag     1080

ctcgagaacc tggagatcaa cctgaggaag gagatcgcca aggcgttcaa gggcaacgag     1140

ggctacaagt ccctcttcaa gaaggacatc atcgagacga tcctcccgga gttcctggac     1200

gacaaggacg agatcgccct ggtcaactcc ttcaacggct tcaccacggc gttcaccggc     1260

ttcttcgaca accgcgagaa catgttcagc gaggaggcca agtccacgag catcgcgttc     1320

aggtgcatca acgagaacct cacccgctac atctccaaca tggacatctt cgagaaggtc     1380

gacgcgatct tcgacaagca cgaggtgcag gagatcaagg agaagatcct gaacagcgac     1440

tacgacgtcg aggacttctt cgagggcgag ttcttcaact tcgtcctcac gcaggagggc     1500

atcgacgtgt acaacgccat catcggtggc ttcgtgaccg agtccggcga gaagatcaag     1560

ggcctgaacg agtacatcaa cctctacaac cagaagacca agcagaagct gccgaagttc     1620

aagcccctgt acaagcaggt gctctccgac agggagtccc tcagcttcta cggcgagggc     1680

tacacgagcg acgaggaggt cctggaggtg ttccgcaaca ccctcaacaa gaacagcgag     1740

atcttctcca gcatcaagaa gctcgagaag ctgttcaaga acttcgacga gtactccagc     1800

gccggcatct tcgtcaagaa cggcccggcg atctccacga tcagcaagga catcttcggc     1860

gagtggaacg tgatccgcga caagtggaac gccgagtacg acgacatcca cctcaagaag     1920

aaggcggtgg tcaccgagaa gtacgaggac gacaggcgca agtccttcaa gaagatcggc     1980

tccttcagcc tcgagcagct gcaggagtac gccgacgcgg acctgagcgt ggtcgagaag     2040

ctcaaggaga tcatcatcca gaaggtcgac gagatctaca aggtgtacgg ctccagcgag     2100

aagctcttcg acgcggactt cgtcctcgag aagtccctga agaagaacga cgccgtggtc     2160

gcgatcatga aggacctcct ggactccgtg aagagcttcg agaattacat caaggccttc     2220

ttcggcgagg gcaaggagac gaacagggac gagtccttct acggcgactt cgtcctggcc     2280

tacgacatcc tcctgaaggt ggaccacatc tacgacgcga tccgcaacta cgtgacccag     2340

aagccgtaca gcaaggacaa gttcaagctc tacttccaga acccccagtt catgggcggc     2400

tgggacaagg acaaggagac ggactacagg gcgaccatcc tgcgctacgg cagcaagtac     2460

tacctcgcca tcatggacaa gaagtacgcg aagtgcctgc agaagatcga caaggacgac     2520

gtcaacggca actacgagaa gatcaactac aagctcctgc cgggccccaa caagatgctc     2580

ccgaaggtgt tcttctccaa gaagtggatg gcctactaca accccagcga ggacatccag     2640

aagatctaca agaacggcac gttcaagaag ggcgacatgt tcaacctgaa cgactgccac     2700

aagctcatcg acttcttcaa ggactccatc agccgctacc cgaagtggtc caacgcctac     2760

gacttcaact tcagcgagac cgagaagtac aaggacatcg cgggcttcta ccgcgaggtc     2820

gaggagcagg gctacaaggt gtccttcgag tccgccagca agaaggaggt cgacaagctg     2880

gtggaggagg gcaagctcta catgttccag atctacaaca aggacttctc cgacaagagc     2940

cacggcacgc ccaacctgca caccatgtac ttcaagctcc tgttcgacga gaacaaccac     3000

ggccagatca ggctgtccgg cggcgccgag ctcttcatga ggagggcgag cctgaagaag     3060

gaggagctgg tggtccaccc cgctaacagc ccaatcgcga acaagaaccc ggacaacccc     3120

aagaagacca cgaccctgtc ctacgacgtg tacaaggaca agaggttcag cgaggaccag     3180

tacgagctcc acatcccgat cgcgatcaac aagtgcccca agaacatctt caagatcaac     3240

accgaggtcc gcgtgctcct gaagcacgac gacaacccct acgtgatcgg catcgctagg     3300

ggcgagagga acctcctgta catcgtggtc gtggacggca agggcaacat cgtggagcag     3360

tactccctca acgagatcat caacaacttc aacggcatca ggatcaagac ggactaccac     3420

agcctcctgg acaagaagga gaaggagagg ttcgaggccc gccagaactg gacctccatc     3480

gagaacatca aggagctgaa ggcgggctac atcagccagg tcgtgcacaa gatctgcgag     3540

ctcgtcgaga agtacgacgc cgtgatcgcc ctcgcggacc tgaactccgg cttcaagaac     3600

agccgcgtca aggtggagaa gcaggtctac cagaagttcg agaagatgct catcgacaag     3660

ctgaactaca tggtggacaa gaagtccaac ccctgcgcta cgggcggcgc gctgaagggc     3720

taccagatca ccaacaagtt cgagagcttc aagtccatga gcactcagaa cggcttcatc     3780

ttctacatcc cggcgtggct cacgtccaag atcgacccca gcaccggctt cgtcaacctc     3840

ctgaagacga agtacacctc catcgccgac agcaagaagt tcatctccag cttcgaccgc     3900

atcatgtatg tgccggagga ggacctgttc gagttcgccc tcgactacaa gaacttctcc     3960

cgcacggacg cggactacat caagaagtgg aagctgtaca gctacggcaa ccgcatccgc     4020

atcttcagga accccaagaa gaacaacgtc ttcgactggg aggaggtgtg cctgacctcc     4080

gcgtacaagg agctcttcaa caagtacggc atcaactacc agcagggcga catcagggct     4140

ctcctgtgcg agcagagcga caaggccttc tactccagct tcatggcgct gatgtccctc     4200

atgctgcaga tgaggaactc gatcaccggc aggacggacg tggccttcct catctccccg     4260

gtgaagaaca gcgacggcat cttctacgac tccaggaact acgaggccca ggagaacgcg     4320

atcctcccaa agaacgcgga cgccaacggc gcctacaaca tcgccaggaa ggtcctctgg     4380

gctatcggcc agttcaagaa ggcggaggac gagaagctgg acaaggtgaa gatcgccatc     4440

agcaacaagg agtggctcga gtacgcccag acctcggtca agcacggcag cccgaagaag     4500

aagcgcaagg tgtccggcgg cagcacgaac ctgtccgaca tcatcgagaa ggagaccggc     4560

aagcagctcg tgatccagga gagcatcctc atgctgccgg aggaggtcga ggaggtcatc     4620

ggcaacaagc ccgagtccga catcctcgtc cacacggcct acgacgagtc caccgacgag     4680

aacgtgatgc tcctgacctc ggacgctccc gagtacaagc catgggccct ggtcatccag     4740

gacagcaacg gcgagaacaa gatcaagatg ctctccggcg gcagcccgaa gaagaagcgc     4800

aaagtgtga                                                             4809


<210>  24
<211>  1602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Protein

<400>  24

Met Pro Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val 
1               5                   10                  15      


Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu 
            20                  25                  30          


Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr 
        35                  40                  45              


Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln 
    50                  55                  60                  


Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr 
65                  70                  75                  80  


Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu 
                85                  90                  95      


Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu 
            100                 105                 110         


Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr 
        115                 120                 125             


His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser 
    130                 135                 140                 


Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys 
145                 150                 155                 160 


Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro 
                165                 170                 175     


Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys 
            180                 185                 190         


Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln 
        195                 200                 205             


Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln 
    210                 215                 220                 


Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Lys Leu Glu 
            260                 265                 270         


Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala 
        275                 280                 285             


Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu 
    290                 295                 300                 


Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu 
305                 310                 315                 320 


Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile 
                325                 330                 335     


Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr 
            340                 345                 350         


Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu 
        355                 360                 365             


Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser 
    370                 375                 380                 


Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp 
385                 390                 395                 400 


Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr 
                405                 410                 415     


Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu 
            420                 425                 430         


Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr 
        435                 440                 445             


Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe 
    450                 455                 460                 


Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp 
465                 470                 475                 480 


Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu 
                485                 490                 495     


Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val 
            500                 505                 510         


Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu 
        515                 520                 525             


Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr 
    530                 535                 540                 


Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly 
545                 550                 555                 560 


Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn 
                565                 570                 575     


Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe 
            580                 585                 590         


Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly 
        595                 600                 605             


Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val 
    610                 615                 620                 


Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys 
625                 630                 635                 640 


Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe 
                645                 650                 655     


Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp 
            660                 665                 670         


Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys 
        675                 680                 685             


Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp 
    690                 695                 700                 


Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val 
705                 710                 715                 720 


Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr 
                725                 730                 735     


Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser 
            740                 745                 750         


Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp 
        755                 760                 765             


His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser 
    770                 775                 780                 


Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly 
785                 790                 795                 800 


Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr 
                805                 810                 815     


Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys 
            820                 825                 830         


Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile 
        835                 840                 845             


Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe 
    850                 855                 860                 


Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln 
865                 870                 875                 880 


Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu 
                885                 890                 895     


Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg 
            900                 905                 910         


Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu 
        915                 920                 925             


Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly 
    930                 935                 940                 


Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu 
945                 950                 955                 960 


Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe 
                965                 970                 975     


Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys 
            980                 985                 990         


Leu Leu Phe Asp Glu Asn Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly 
        995                 1000                 1005             


Ala Glu  Leu Phe Met Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu 
    1010                 1015                 1020             


Val Val  His Pro Ala Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp 
    1025                 1030                 1035             


Asn Pro  Lys Lys Thr Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp 
    1040                 1045                 1050             


Lys Arg  Phe Ser Glu Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala 
    1055                 1060                 1065             


Ile Asn  Lys Cys Pro Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val 
    1070                 1075                 1080             


Arg Val  Leu Leu Lys His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile 
    1085                 1090                 1095             


Ala Arg  Gly Glu Arg Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly 
    1100                 1105                 1110             


Lys Gly  Asn Ile Val Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn 
    1115                 1120                 1125             


Asn Phe  Asn Gly Ile Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu 
    1130                 1135                 1140             


Asp Lys  Lys Glu Lys Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr 
    1145                 1150                 1155             


Ser Ile  Glu Asn Ile Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln 
    1160                 1165                 1170             


Val Val  His Lys Ile Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val 
    1175                 1180                 1185             


Ile Ala  Leu Ala Asp Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val 
    1190                 1195                 1200             


Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile 
    1205                 1210                 1215             


Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala 
    1220                 1225                 1230             


Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu 
    1235                 1240                 1245             


Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile 
    1250                 1255                 1260             


Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val 
    1265                 1270                 1275             


Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys 
    1280                 1285                 1290             


Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp 
    1295                 1300                 1305             


Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp 
    1310                 1315                 1320             


Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg 
    1325                 1330                 1335             


Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp 
    1340                 1345                 1350             


Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys 
    1355                 1360                 1365             


Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys 
    1370                 1375                 1380             


Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met 
    1385                 1390                 1395             


Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile Thr Gly  Arg Thr Asp 
    1400                 1405                 1410             


Val Ala  Phe Leu Ile Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe 
    1415                 1420                 1425             


Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro 
    1430                 1435                 1440             


Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val 
    1445                 1450                 1455             


Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu 
    1460                 1465                 1470             


Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr 
    1475                 1480                 1485             


Ala Gln  Thr Ser Val Lys His  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1490                 1495                 1500             


Val Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1505                 1510                 1515             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1520                 1525                 1530             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1535                 1540                 1545             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1550                 1555                 1560             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1565                 1570                 1575             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1580                 1585                 1590             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1595                 1600         


<210>  25
<211>  1802
<212>  DNA
<213>  Saccharum officinarum

<400>  25
gaattcatta tgtggtctag gtaggttcta tatataagaa aacttgaaat gttctaaaaa       60

aaaattcaag cccatgcatg attgaagcaa acggtatagc aacggtgtta acctgatcta      120

gtgatctctt gcaatcctta acggccacct accgcaggta gcaaacggcg tccccctcct      180

cgatatctcc gcggcgacct ctggcttttt ccgcggaatt gcgcggtggg gacggattcc      240

acgagaccgc gacgcaaccg cctctcgccg ctgggcccca caccgctcgg tgccgtagcc      300

tcacgggact ctttctccct cctcccccgt tataaattgg cttcatcccc tccttgcctc      360

atccatccaa atcccagtcc ccaatcccat cccttcgtag gagaaattca tcgaagctaa      420

gcgaatcctc gcgatcctct caaggtactg cgagttttcg atccccctct cgacccctcg      480

tatgtttgtg tttgtcgtag cgtttgatta ggtatgcttt ccctgtttgt gttcgtcgta      540

gcgtttgatt aggtatgctt tccctgttcg tgttcatcgt agtgtttgat taggtcgtgt      600

gaggcgatgg cctgctcgcg tccttcgatc tgtagtcgat ttgcgggtcg tggtgtagat      660

ctgcgggctg tgatgaagtt atttggtgtg atctgctcgc ctgattctgc gggttggctc      720

gagtagatat gatggttgga ccggttggtt cgtttaccgc gctagggttg ggctgggatg      780

atgttgcatg cgccgttgcg cgtgatcccg cagcaggact tgcgtttgat tgccagatct      840

cgttacgatt atgtgatttg gtttggactt tttagatctg tagcttctgc ttatgtgcca      900

gatgcgccta ctgctcatat gcctgatgat aatcataaat ggctgtggaa ctaactagtt      960

gattgcggag tcatgtatca gctacaggtg tagggactag ctacaggtgt agggacttgc     1020

gtctaattgt ttggtccttt actcatgttg caattatgca atttagttta gattgtttgt     1080

tccactcatc taggctgtaa aagggacact gcttagattg ctgtttaatc tttttagtag     1140

attatattat attggtaact tattacccct attacatgcc atacgtgact tctgctcatg     1200

cctgatgata atcatagatc actgtggaat taattagttg attgttgaat catgtttcat     1260

gtacatacca cggcacaatt gcttagttcc ttaacaaatg caaattttac tgatccatgt     1320

atgatttgcg tggttctcta atgtgaaata ctatagctac ttgttagtaa gaatcaggtt     1380

cgtatgctta atgctgtatg tgccttctgc tcatgcctga tgataatcat atatcactgg     1440

aattaattag ttgatcgttt aatcatatat caagtacata ccatgccaca atttttagtc     1500

acttaaccca tgcagattga actggtccct gcatgttttg ctaaattgtt ctattctgat     1560

tagaccatat atcatgtatt tttttttggt aatggttctc ttattttaaa tgctatatag     1620

ttctggtact tgttagaaag atctgcttca tagtttagtt gcctatccct cgaattagga     1680

tgctgagcag ctgatcctat agctttgttt catgtatcaa ttcttttgtg ttcaacagtc     1740

agtttttgtt agattcattg taacttatgg tcgcttactc ttctggtcct caatgcttgc     1800

ag                                                                    1802


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26
gggaaagacc gaggagaaga tct                                               23


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
aagaccgagg agaagatcta                                                   20


<210>  28
<211>  90
<212>  DNA
<213>  Zea mays

<400>  28
gtttggggaa agaccgagga gaagatctac gggcctgtcg ctggaacgga ctacagggac       60

aaccagctgc ggttcagcct gctatgccag                                        90


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
agatgggaga cgggtacgag acgg                                              24


<210>  30
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
gtatgggttg ttgttgaggc tcagg                                             25


<210>  31
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
gaccacccac tgttcctgga gaggg                                             25


<210>  32
<211>  3783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synethic

<400>  32
atggctccta agaagaagcg gaaggttggt attcacgggg tgcctgcggc ttcaaagctc       60

gagaaattca ccaactgtta ttcgttgagc aaaacactgc ggtttaaagc gattccagtc      120

ggcaagactc aagagaatat agacaataag cggctgttgg tggaagatga aaagcgcgcg      180

gaagactaca aaggggtgaa gaagttgttg gacagatact acctctcttt tatcaatgat      240

gtcttgcact caatcaaatt gaagaatctg aacaactaca tctccctctt cagaaagaaa      300

acaaggacag aaaaggagaa taaggaactt gaaaatttgg agatcaatct gaggaaagag      360

atcgcgaaag cctttaaagg caacgaagga tacaaaagtc tgttcaagaa ggatataatt      420

gagacaattt tgccagagtt cctcgatgac aaggacgaga ttgcgctggt caattcgttc      480

aacggattca caacagcatt cacaggcttc tttgataatc gggaaaatat gttctctgag      540

gaggcaaagt ccacttctat tgcgttcagg tgtatcaatg agaatctcac taggtacatt      600

tccaacatgg atatctttga gaaggttgac gcaatttttg acaagcacga agttcaggag      660

attaaggaga agatcctcaa ttccgattat gacgttgagg acttcttcga gggtgagttt      720

tttaatttcg tgctcactca agagggtatc gacgtgtata atgcgatcat cggtgggttc      780

gtgactgagt ccggtgaaaa gattaaggga ttgaacgagt atatcaacct ttacaaccaa      840

aagacgaaac agaagctgcc aaagttcaag cctctttaca aacaggttct ttcagaccgc      900

gagtcactct cgttctatgg ggagggctac acttcggatg aggaagtcct ggaggtgttc      960

aggaatactc tcaataagaa ttcggagatt ttctcttcta taaaaaaact ggaaaagttg     1020

tttaagaatt ttgacgaata ctctagcgcc ggcatatttg tgaaaaacgg cccggccata     1080

tcaacgataa gtaaagatat cttcggcgaa tggaacgtga tcagagacaa atggaacgcg     1140

gagtatgacg atattcacct gaagaagaag gctgtcgtaa cggagaagta cgaggatgat     1200

cgcaggaaaa gcttcaaaaa gatcggaagt ttcagcctgg aacagttgca ggagtatgct     1260

gacgccgatc ttagcgtcgt cgagaagttg aaggagataa tcatccaaaa ggtcgacgag     1320

atatataaag tctatggatc aagtgaaaaa ctgttcgacg ccgacttcgt tttggagaag     1380

tccctgaaga agaacgacgc tgttgttgcc attatgaagg atctgctcga cagcgtgaag     1440

agtttcgaga actatattaa ggcttttttc ggggagggga aggagactaa cagagatgag     1500

tccttctacg gagacttcgt cctcgcgtac gatatactcc ttaaggtaga ccacatctac     1560

gacgcaatca gaaattacgt gacacaaaag ccgtacagca aggacaagtt caaactctac     1620

ttccagaacc cccagttcat gggcggctgg gacaaggaca aggaaacgga ttacagggct     1680

acgatcctga ggtatggttc aaaatactac ttggcgatta tggacaagaa gtacgccaag     1740

tgtctccaga agattgacaa agacgatgtc aatggcaatt atgagaagat caactacaag     1800

ctgcttccgg gtccgaacaa gatgctccca aaggttttct tcagcaagaa atggatggcc     1860

tactataacc caagcgagga catccagaag atttataaga acggtacgtt caagaagggc     1920

gacatgttca atcttaacga ctgtcacaag ctgatcgact tcttcaaaga ctcaattagc     1980

cggtacccaa agtggtctaa cgcctatgac ttcaactttt cggaaaccga gaagtacaag     2040

gatatagccg gattttatag agaggtggaa gagcagggct acaaggtgtc attcgagtcc     2100

gccagcaaga aggaagtgga caagctcgtg gaagagggta agctctacat gttccagatt     2160

tataataaag actttagcga taagagccac gggacaccta atctccacac aatgtatttc     2220

aagctgctct tcgacgagaa taaccacggc caaatcaggt tgtcaggagg ggctgaactc     2280

ttcatgcggc gcgctagcct taagaaggag gagcttgtag tccaccctgc gaatagtcca     2340

attgcgaata agaacccgga caatcctaaa aagactacaa cattgagcta cgacgtgtac     2400

aaggataaga ggttttccga ggatcagtac gagctccaca tcccgattgc gatcaacaag     2460

tgcccaaaga atattttcaa gataaacaca gaggtgcgtg tactcctgaa gcatgacgac     2520

aatccttacg tcattgggat tgatcggggc gagaggaacc tcctctatat tgtggtggtg     2580

gacgggaagg ggaacatagt cgaacagtac tcccttaacg aaataattaa caatttcaac     2640

ggcatccgta tcaagaccga ctaccattcg ttgctggaca agaaggagaa ggagagattt     2700

gaggcgcggc aaaattggac aagtatcgag aacatcaagg aactcaaagc aggttatatc     2760

tctcaagttg tgcataagat atgcgagctg gttgagaagt atgacgcagt gatcgctctt     2820

gaggacctca actcgggctt taagaattct agagttaaag tggagaagca ggtctatcaa     2880

aagttcgaga agatgcttat agataagctc aactacatgg tcgataagaa atcgaaccca     2940

tgtgccaccg gcggcgcact caaaggttac caaataacaa acaaattcga gtccttcaaa     3000

tcgatgagta ctcagaatgg gttcatattt tatataccgg cgtggcttac gtctaagatc     3060

gacccgtcaa ctggttttgt caacctgttg aagacgaaat acacgtccat tgccgattca     3120

aaaaagttca tatctagttt tgatcgtatt atgtacgtcc cagaggaaga tcttttcgag     3180

tttgctctcg actacaaaaa cttttcgcgc accgatgcgg attacattaa aaaatggaaa     3240

ctctattcgt acggcaacag aatcaggatt tttcgcaacc ctaagaagaa taacgtcttt     3300

gattgggagg aagtttgctt gactagcgcg tacaaggagc tctttaataa gtatggcatt     3360

aactaccaac agggtgatat cagagcactg ctttgcgaac aatctgacaa ggctttctac     3420

tcatccttca tggctttgat gagcctgatg ctccagatga gaaattcaat tacaggcaga     3480

accgacgtgg atttcttgat ctccccggtt aaaaattctg atggcatctt ttacgatagc     3540

aggaactatg aagcgcaaga gaatgcgatt ctgccaaaaa atgcagacgc caacggtgcc     3600

tataacatcg ccaggaaagt cctgtgggcg atcggccagt tcaaaaaggc cgaagacgaa     3660

aaattggaca aggtcaaaat cgctatcagc aacaaagagt ggctggagta tgctcagaca     3720

tccgtaaagc ataagcgtcc tgctgccacc aaaaaggccg gacaggctaa gaaaaagaag     3780

tga                                                                   3783


<210>  33
<211>  1260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  33

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
            20                  25                  30          


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
        35                  40                  45              


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
    50                  55                  60                  


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
65                  70                  75                  80  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
                85                  90                  95      


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
            100                 105                 110         


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
        115                 120                 125             


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
    130                 135                 140                 


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
145                 150                 155                 160 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
                165                 170                 175     


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
            180                 185                 190         


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
        195                 200                 205             


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
    210                 215                 220                 


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
225                 230                 235                 240 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
                245                 250                 255     


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
            260                 265                 270         


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
        275                 280                 285             


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
    290                 295                 300                 


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
305                 310                 315                 320 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
                325                 330                 335     


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
            340                 345                 350         


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
        355                 360                 365             


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
    370                 375                 380                 


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
385                 390                 395                 400 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
                405                 410                 415     


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
            420                 425                 430         


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
        435                 440                 445             


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
    450                 455                 460                 


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
465                 470                 475                 480 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
                485                 490                 495     


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
            500                 505                 510         


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
        515                 520                 525             


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
    530                 535                 540                 


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
545                 550                 555                 560 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
                565                 570                 575     


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
            580                 585                 590         


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
        595                 600                 605             


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
    610                 615                 620                 


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
625                 630                 635                 640 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
                645                 650                 655     


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
            660                 665                 670         


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
        675                 680                 685             


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
    690                 695                 700                 


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
705                 710                 715                 720 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
                725                 730                 735     


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
            740                 745                 750         


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
        755                 760                 765             


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
    770                 775                 780                 


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
785                 790                 795                 800 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
                805                 810                 815     


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
            820                 825                 830         


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
        835                 840                 845             


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
    850                 855                 860                 


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
865                 870                 875                 880 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
                885                 890                 895     


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
            900                 905                 910         


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
        915                 920                 925             


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
    930                 935                 940                 


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
945                 950                 955                 960 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
                965                 970                 975     


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
            980                 985                 990         


Thr Asn Lys Phe Glu Ser Phe Lys  Ser Met Ser Thr Gln  Asn Gly Phe 
        995                 1000                 1005             


Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
    1010                 1015                 1020             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1025                 1030                 1035             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1040                 1045                 1050             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1055                 1060                 1065             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1070                 1075                 1080             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1085                 1090                 1095             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1100                 1105                 1110             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1115                 1120                 1125             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1130                 1135                 1140             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1145                 1150                 1155             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1160                 1165                 1170             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1175                 1180                 1185             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1190                 1195                 1200             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1205                 1210                 1215             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1220                 1225                 1230             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Lys  Arg Pro Ala 
    1235                 1240                 1245             


Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys Lys Lys  
    1250                 1255                 1260 


<210>  34
<211>  3873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
atgccgaaga agaagcgcaa ggtcgggggc gggggctcag gcgggggcgg gagcggcggc       60

gggggctctg ggggcggcgg cagcggcggg ggcggcagcg ggggcggcgg gtcgatgagc      120

aagctggaga agttcacgaa ctgctactcc ctcagcaaga ccctgaggtt caaggcgatc      180

ccggtcggca agacccagga gaacatcgac aacaagcggc tgctggtgga ggacgagaag      240

agggctgagg actacaaggg cgtgaagaag ctcctggacc gctactacct gtccttcatc      300

aacgacgtgc tccacagcat caagctcaag aacctgaaca actacatcag cctcttcagg      360

aagaagacgc gcaccgagaa ggagaacaag gagctcgaga acctggagat caacctgagg      420

aaggagatcg ccaaggcgtt caagggcaac gagggctaca agtccctctt caagaaggac      480

atcatcgaga cgatcctccc ggagttcctg gacgacaagg acgagatcgc cctggtcaac      540

tccttcaacg gcttcaccac ggcgttcacc ggcttcttcg acaaccgcga gaacatgttc      600

agcgaggagg ccaagtccac gagcatcgcg ttcaggtgca tcaacgagaa cctcacccgc      660

tacatctcca acatggacat cttcgagaag gtcgacgcga tcttcgacaa gcacgaggtg      720

caggagatca aggagaagat cctgaacagc gactacgacg tcgaggactt cttcgagggc      780

gagttcttca acttcgtcct cacgcaggag ggcatcgacg tgtacaacgc catcatcggt      840

ggcttcgtga ccgagtccgg cgagaagatc aagggcctga acgagtacat caacctctac      900

aaccagaaga ccaagcagaa gctgccgaag ttcaagcccc tgtacaagca ggtgctctcc      960

gacagggagt ccctcagctt ctacggcgag ggctacacga gcgacgagga ggtcctggag     1020

gtgttccgca acaccctcaa caagaacagc gagatcttct ccagcatcaa gaagctcgag     1080

aagctgttca agaacttcga cgagtactcc agcgccggca tcttcgtcaa gaacggcccg     1140

gcgatctcca cgatcagcaa ggacatcttc ggcgagtgga acgtgatccg cgacaagtgg     1200

aacgccgagt acgacgacat ccacctcaag aagaaggcgg tggtcaccga gaagtacgag     1260

gacgacaggc gcaagtcctt caagaagatc ggctccttca gcctcgagca gctgcaggag     1320

tacgccgacg cggacctgag cgtggtcgag aagctcaagg agatcatcat ccagaaggtc     1380

gacgagatct acaaggtgta cggctccagc gagaagctct tcgacgcgga cttcgtcctc     1440

gagaagtccc tgaagaagaa cgacgccgtg gtcgcgatca tgaaggacct cctggactcc     1500

gtgaagagct tcgagaatta catcaaggcc ttcttcggcg agggcaagga gacgaacagg     1560

gacgagtcct tctacggcga cttcgtcctg gcctacgaca tcctcctgaa ggtggaccac     1620

atctacgacg cgatccgcaa ctacgtgacc cagaagccgt acagcaagga caagttcaag     1680

ctctacttcc agaaccccca gttcatgggc ggctgggaca aggacaagga gacggactac     1740

agggcgacca tcctgcgcta cggcagcaag tactacctcg ccatcatgga caagaagtac     1800

gcgaagtgcc tgcagaagat cgacaaggac gacgtcaacg gcaactacga gaagatcaac     1860

tacaagctcc tgccgggccc caacaagatg ctcccgaagg tgttcttctc caagaagtgg     1920

atggcctact acaaccccag cgaggacatc cagaagatct acaagaacgg cacgttcaag     1980

aagggcgaca tgttcaacct gaacgactgc cacaagctca tcgacttctt caaggactcc     2040

atcagccgct acccgaagtg gtccaacgcc tacgacttca acttcagcga gaccgagaag     2100

tacaaggaca tcgcgggctt ctaccgcgag gtcgaggagc agggctacaa ggtgtccttc     2160

gagtccgcca gcaagaagga ggtcgacaag ctggtggagg agggcaagct ctacatgttc     2220

cagatctaca acaaggactt ctccgacaag agccacggca cgcccaacct gcacaccatg     2280

tacttcaagc tcctgttcga cgagaacaac cacggccaga tcaggctgtc cggcggcgcc     2340

gagctcttca tgaggagggc gagcctgaag aaggaggagc tggtggtcca ccccgctaac     2400

agcccaatcg cgaacaagaa cccggacaac cccaagaaga ccacgaccct gtcctacgac     2460

gtgtacaagg acaagaggtt cagcgaggac cagtacgagc tccacatccc gatcgcgatc     2520

aacaagtgcc ccaagaacat cttcaagatc aacaccgagg tccgcgtgct cctgaagcac     2580

gacgacaacc cctacgtgat cggcatcgac aggggcgaga ggaacctcct gtacatcgtg     2640

gtcgtggacg gcaagggcaa catcgtggag cagtactccc tcaacgagat catcaacaac     2700

ttcaacggca tcaggatcaa gacggactac cacagcctcc tggacaagaa ggagaaggag     2760

aggttcgagg cccgccagaa ctggacctcc atcgagaaca tcaaggagct gaaggcgggc     2820

tacatcagcc aggtcgtgca caagatctgc gagctcgtcg agaagtacga cgccgtgatc     2880

gccctcgagg acctgaactc cggcttcaag aacagccgcg tcaaggtgga gaagcaggtc     2940

taccagaagt tcgagaagat gctcatcgac aagctgaact acatggtgga caagaagtcc     3000

aacccctgcg ctacgggcgg cgcgctgaag ggctaccaga tcaccaacaa gttcgagagc     3060

ttcaagtcca tgagcactca gaacggcttc atcttctaca tcccggcgtg gctcacgtcc     3120

aagatcgacc ccagcaccgg cttcgtcaac ctcctgaaga cgaagtacac ctccatcgcc     3180

gacagcaaga agttcatctc cagcttcgac cgcatcatgt atgtgccgga ggaggacctg     3240

ttcgagttcg ccctcgacta caagaacttc tcccgcacgg acgcggacta catcaagaag     3300

tggaagctgt acagctacgg caaccgcatc cgcatcttca ggaaccccaa gaagaacaac     3360

gtcttcgact gggaggaggt gtgcctgacc tccgcgtaca aggagctctt caacaagtac     3420

ggcatcaact accagcaggg cgacatcagg gctctcctgt gcgagcagag cgacaaggcc     3480

ttctactcca gcttcatggc gctgatgtcc ctcatgctgc agatgaggaa ctcgatcacc     3540

ggcaggacgg acgtggactt cctcatctcc ccggtgaaga acagcgacgg catcttctac     3600

gactccagga actacgaggc ccaggagaac gcgatcctcc caaagaacgc ggacgccaac     3660

ggcgcctaca acatcgccag gaaggtcctc tgggctatcg gccagttcaa gaaggcggag     3720

gacgagaagc tggacaaggt gaagatcgcc atcagcaaca aggagtggct cgagtacgcc     3780

cagacctcgg tcaagcacgg cagcccgaag aagaagcgca aggtgtccgg cggcagctcc     3840

ggcggcagcc cgaagaagaa gcgcaaagtg tga                                  3873


<210>  35
<211>  1290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  35

Met Pro Lys Lys Lys Arg Lys Val Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn Cys 
        35                  40                  45              


Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys 
    50                  55                  60                  


Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys 
65                  70                  75                  80  


Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr 
                85                  90                  95      


Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu 
            100                 105                 110         


Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu 
        115                 120                 125             


Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala 
    130                 135                 140                 


Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp 
145                 150                 155                 160 


Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile 
                165                 170                 175     


Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe 
            180                 185                 190         


Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser 
        195                 200                 205             


Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn 
    210                 215                 220                 


Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val 
225                 230                 235                 240 


Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp 
                245                 250                 255     


Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile 
            260                 265                 270         


Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu 
        275                 280                 285             


Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr 
    290                 295                 300                 


Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser 
305                 310                 315                 320 


Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu 
                325                 330                 335     


Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile 
            340                 345                 350         


Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu 
        355                 360                 365             


Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr 
    370                 375                 380                 


Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp 
385                 390                 395                 400 


Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr 
                405                 410                 415     


Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser 
            420                 425                 430         


Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val 
        435                 440                 445             


Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr 
    450                 455                 460                 


Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu 
465                 470                 475                 480 


Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp 
                485                 490                 495     


Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe 
            500                 505                 510         


Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe 
        515                 520                 525             


Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala 
    530                 535                 540                 


Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys 
545                 550                 555                 560 


Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys 
                565                 570                 575     


Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr 
            580                 585                 590         


Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp 
        595                 600                 605             


Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu 
    610                 615                 620                 


Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp 
625                 630                 635                 640 


Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn 
                645                 650                 655     


Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys 
            660                 665                 670         


Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser 
        675                 680                 685             


Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile 
    690                 695                 700                 


Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe 
705                 710                 715                 720 


Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys 
                725                 730                 735     


Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His 
            740                 745                 750         


Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu 
        755                 760                 765             


Asn Asn His Gly Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met 
    770                 775                 780                 


Arg Arg Ala Ser Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn 
785                 790                 795                 800 


Ser Pro Ile Ala Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr 
                805                 810                 815     


Leu Ser Tyr Asp Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr 
            820                 825                 830         


Glu Leu His Ile Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe 
        835                 840                 845             


Lys Ile Asn Thr Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro 
    850                 855                 860                 


Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val 
865                 870                 875                 880 


Val Val Asp Gly Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu 
                885                 890                 895     


Ile Ile Asn Asn Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser 
            900                 905                 910         


Leu Leu Asp Lys Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp 
        915                 920                 925             


Thr Ser Ile Glu Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln 
    930                 935                 940                 


Val Val His Lys Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile 
945                 950                 955                 960 


Ala Leu Glu Asp Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val 
                965                 970                 975     


Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu 
            980                 985                 990         


Asn Tyr Met Val Asp Lys Lys Ser  Asn Pro Cys Ala Thr  Gly Gly Ala 
        995                 1000                 1005             


Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe Glu Ser  Phe Lys Ser 
    1010                 1015                 1020             


Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu 
    1025                 1030                 1035             


Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys 
    1040                 1045                 1050             


Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser 
    1055                 1060                 1065             


Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe 
    1070                 1075                 1080             


Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile 
    1085                 1090                 1095             


Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe 
    1100                 1105                 1110             


Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys 
    1115                 1120                 1125             


Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn 
    1130                 1135                 1140             


Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp 
    1145                 1150                 1155             


Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu Met Ser  Leu Met Leu 
    1160                 1165                 1170             


Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu 
    1175                 1180                 1185             


Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg 
    1190                 1195                 1200             


Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp 
    1205                 1210                 1215             


Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile 
    1220                 1225                 1230             


Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys 
    1235                 1240                 1245             


Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser 
    1250                 1255                 1260             


Val Lys  His Gly Ser Pro Lys  Lys Lys Arg Lys Val  Ser Gly Gly 
    1265                 1270                 1275             


Ser Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1280                 1285                 1290 


<210>  36
<211>  3783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
atggctccta agaagaagcg gaaggttggt attcacgggg tgcctgcggc ttcaaagctc       60

gagaaattca ccaactgtta ttcgttgagc aaaacactgc ggtttaaagc gattccagtc      120

ggcaagactc aagagaatat agacaataag cggctgttgg tggaagatga aaagcgcgcg      180

gaagactaca aaggggtgaa gaagttgttg gacagatact acctctcttt tatcaatgat      240

gtcttgcact caatcaaatt gaagaatctg aacaactaca tctccctctt cagaaagaaa      300

acaaggacag aaaaggagaa taaggaactt gaaaatttgg agatcaatct gaggaaagag      360

atcgcgaaag cctttaaagg caacgaagga tacaaaagtc tgttcaagaa ggatataatt      420

gagacaattt tgccagagtt cctcgatgac aaggacgaga ttgcgctggt caattcgttc      480

aacggattca caacagcatt cacaggcttc tttgataatc gggaaaatat gttctctgag      540

gaggcaaagt ccacttctat tgcgttcagg tgtatcaatg agaatctcac taggtacatt      600

tccaacatgg atatctttga gaaggttgac gcaatttttg acaagcacga agttcaggag      660

attaaggaga agatcctcaa ttccgattat gacgttgagg acttcttcga gggtgagttt      720

tttaatttcg tgctcactca agagggtatc gacgtgtata atgcgatcat cggtgggttc      780

gtgactgagt ccggtgaaaa gattaaggga ttgaacgagt atatcaacct ttacaaccaa      840

aagacgaaac agaagctgcc aaagttcaag cctctttaca aacaggttct ttcagaccgc      900

gagtcactct cgttctatgg ggagggctac acttcggatg aggaagtcct ggaggtgttc      960

aggaatactc tcaataagaa ttcggagatt ttctcttcta taaaaaaact ggaaaagttg     1020

tttaagaatt ttgacgaata ctctagcgcc ggcatatttg tgaaaaacgg cccggccata     1080

tcaacgataa gtaaagatat cttcggcgaa tggaacgtga tcagagacaa atggaacgcg     1140

gagtatgacg atattcacct gaagaagaag gctgtcgtaa cggagaagta cgaggatgat     1200

cgcaggaaaa gcttcaaaaa gatcggaagt ttcagcctgg aacagttgca ggagtatgct     1260

gacgccgatc ttagcgtcgt cgagaagttg aaggagataa tcatccaaaa ggtcgacgag     1320

atatataaag tctatggatc aagtgaaaaa ctgttcgacg ccgacttcgt tttggagaag     1380

tccctgaaga agaacgacgc tgttgttgcc attatgaagg atctgctcga cagcgtgaag     1440

agtttcgaga actatattaa ggcttttttc ggggagggga aggagactaa cagagatgag     1500

tccttctacg gagacttcgt cctcgcgtac gatatactcc ttaaggtaga ccacatctac     1560

gacgcaatca gaaattacgt gacacaaaag ccgtacagca aggacaagtt caaactctac     1620

ttccagaacc cccagttcat gggcggctgg gacaaggaca aggaaacgga ttacagggct     1680

acgatcctga ggtatggttc aaaatactac ttggcgatta tggacaagaa gtacgccaag     1740

tgtctccaga agattgacaa agacgatgtc aatggcaatt atgagaagat caactacaag     1800

ctgcttccgg gtccgaacaa gatgctccca aaggttttct tcagcaagaa atggatggcc     1860

tactataacc caagcgagga catccagaag atttataaga acggtacgtt caagaagggc     1920

gacatgttca atcttaacga ctgtcacaag ctgatcgact tcttcaaaga ctcaattagc     1980

cggtacccaa agtggtctaa cgcctatgac ttcaactttt cggaaaccga gaagtacaag     2040

gatatagccg gattttatag agaggtggaa gagcagggct acaaggtgtc attcgagtcc     2100

gccagcaaga aggaagtgga caagctcgtg gaagagggta agctctacat gttccagatt     2160

tataataaag actttagcga taagagccac gggacaccta atctccacac aatgtatttc     2220

aagctgctct tcgacgagaa taaccacggc caaatcaggt tgtcaggagg ggctgaactc     2280

ttcatgcggc gcgctagcct taagaaggag gagcttgtag tccaccctgc gaatagtcca     2340

attgcgaata agaacccgga caatcctaaa aagactacaa cattgagcta cgacgtgtac     2400

aaggataaga ggttttccga ggatcagtac gagctccaca tcccgattgc gatcaacaag     2460

tgcccaaaga atattttcaa gataaacaca gaggtgcgtg tactcctgaa gcatgacgac     2520

aatccttacg tcattgggat tgatcggggc gagaggaacc tcctctatat tgtggtggtg     2580

gacgggaagg ggaacatagt cgaacagtac tcccttaacg aaataattaa caatttcaac     2640

ggcatccgta tcaagaccga ctaccattcg ttgctggaca agaaggagaa ggagagattt     2700

gaggcgcggc aaaattggac aagtatcgag aacatcaagg aactcaaagc aggttatatc     2760

tctcaagttg tgcataagat atgcgagctg gttgagaagt atgacgcagt gatcgctctt     2820

gaggacctca actcgggctt taagaattct agagttaaag tggagaagca ggtctatcaa     2880

aagttcgaga agatgcttat agataagctc aactacatgg tcgataagaa atcgaaccca     2940

tgtgccaccg gcggcgcact caaaggttac caaataacaa acaaattcga gtccttcaaa     3000

tcgatgagta ctcagaatgg gttcatattt tatataccgg cgtggcttac gtctaagatc     3060

gacccgtcaa ctggttttgt caacctgttg aagacgaaat acacgtccat tgccgattca     3120

aaaaagttca tatctagttt tgatcgtatt atgtacgtcc cagaggaaga tcttttcgag     3180

tttgctctcg actacaaaaa cttttcgcgc accgatgcgg attacattaa aaaatggaaa     3240

ctctattcgt acggcaacag aatcaggatt tttcgcaacc ctaagaagaa taacgtcttt     3300

gattgggagg aagtttgctt gactagcgcg tacaaggagc tctttaataa gtatggcatt     3360

aactaccaac agggtgatat cagagcactg ctttgcgaac aatctgacaa ggctttctac     3420

tcatccttca tggctttgat gagcctgatg ctccagatga gaaattcaat tacaggcaga     3480

accgacgtgg atttcttgat ctccccggtt aaaaattctg atggcatctt ttacgatagc     3540

aggaactatg aagcgcaaga gaatgcgatt ctgccaaaaa atgcagacgc caacggtgcc     3600

tataacatcg ccaggaaagt cctgtgggcg atcggccagt tcaaaaaggc cgaagacgaa     3660

aaattggaca aggtcaaaat cgctatcagc aacaaagagt ggctggagta tgctcagaca     3720

tccgtaaagc ataagcgtcc tgctgccacc aaaaaggccg gacaggctaa gaaaaagaag     3780

tga                                                                   3783


<210>  37
<211>  1260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  37

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
            20                  25                  30          


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
        35                  40                  45              


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
    50                  55                  60                  


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
65                  70                  75                  80  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
                85                  90                  95      


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
            100                 105                 110         


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
        115                 120                 125             


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
    130                 135                 140                 


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
145                 150                 155                 160 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
                165                 170                 175     


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
            180                 185                 190         


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
        195                 200                 205             


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
    210                 215                 220                 


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
225                 230                 235                 240 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
                245                 250                 255     


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
            260                 265                 270         


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
        275                 280                 285             


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
    290                 295                 300                 


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
305                 310                 315                 320 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
                325                 330                 335     


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
            340                 345                 350         


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
        355                 360                 365             


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
    370                 375                 380                 


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
385                 390                 395                 400 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
                405                 410                 415     


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
            420                 425                 430         


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
        435                 440                 445             


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
    450                 455                 460                 


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
465                 470                 475                 480 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
                485                 490                 495     


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
            500                 505                 510         


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
        515                 520                 525             


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
    530                 535                 540                 


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
545                 550                 555                 560 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
                565                 570                 575     


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
            580                 585                 590         


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
        595                 600                 605             


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
    610                 615                 620                 


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
625                 630                 635                 640 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
                645                 650                 655     


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
            660                 665                 670         


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
        675                 680                 685             


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
    690                 695                 700                 


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
705                 710                 715                 720 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
                725                 730                 735     


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
            740                 745                 750         


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
        755                 760                 765             


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
    770                 775                 780                 


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
785                 790                 795                 800 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
                805                 810                 815     


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
            820                 825                 830         


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
        835                 840                 845             


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
    850                 855                 860                 


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
865                 870                 875                 880 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
                885                 890                 895     


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
            900                 905                 910         


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
        915                 920                 925             


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
    930                 935                 940                 


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
945                 950                 955                 960 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
                965                 970                 975     


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
            980                 985                 990         


Thr Asn Lys Phe Glu Ser Phe Lys  Ser Met Ser Thr Gln  Asn Gly Phe 
        995                 1000                 1005             


Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
    1010                 1015                 1020             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1025                 1030                 1035             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1040                 1045                 1050             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1055                 1060                 1065             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1070                 1075                 1080             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1085                 1090                 1095             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1100                 1105                 1110             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1115                 1120                 1125             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1130                 1135                 1140             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1145                 1150                 1155             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1160                 1165                 1170             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1175                 1180                 1185             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1190                 1195                 1200             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1205                 1210                 1215             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1220                 1225                 1230             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Lys  Arg Pro Ala 
    1235                 1240                 1245             


Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys Lys Lys  
    1250                 1255                 1260 


<210>  38
<211>  3873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
atgccgaaga agaagcgcaa ggtcgggggc gggggctcag gcgggggcgg gagcggcggc       60

gggggctctg ggggcggcgg cagcggcggg ggcggcagcg ggggcggcgg gtcgatgtca      120

aagctcgaga aattcaccaa ctgttattcg ttgagcaaaa cactgcggtt taaagcgatt      180

ccagtcggca agactcaaga gaatatagac aataagcggc tgttggtgga agatgaaaag      240

cgcgcggaag actacaaagg ggtgaagaag ttgttggaca gatactacct ctcttttatc      300

aatgatgtct tgcactcaat caaattgaag aatctgaaca actacatctc cctcttcaga      360

aagaaaacaa ggacagaaaa ggagaataag gaacttgaaa atttggagat caatctgagg      420

aaagagatcg cgaaagcctt taaaggcaac gaaggataca aaagtctgtt caagaaggat      480

ataattgaga caattttgcc agagttcctc gatgacaagg acgagattgc gctggtcaat      540

tcgttcaacg gattcacaac agcattcaca ggcttctttg ataatcggga aaatatgttc      600

tctgaggagg caaagtccac ttctattgcg ttcaggtgta tcaatgagaa tctcactagg      660

tacatttcca acatggatat ctttgagaag gttgacgcaa tttttgacaa gcacgaagtt      720

caggagatta aggagaagat cctcaattcc gattatgacg ttgaggactt cttcgagggt      780

gagtttttta atttcgtgct cactcaagag ggtatcgacg tgtataatgc gatcatcggt      840

gggttcgtga ctgagtccgg tgaaaagatt aagggattga acgagtatat caacctttac      900

aaccaaaaga cgaaacagaa gctgccaaag ttcaagcctc tttacaaaca ggttctttca      960

gaccgcgagt cactctcgtt ctatggggag ggctacactt cggatgagga agtcctggag     1020

gtgttcagga atactctcaa taagaattcg gagattttct cttctataaa aaaactggaa     1080

aagttgttta agaattttga cgaatactct agcgccggca tatttgtgaa aaacggcccg     1140

gccatatcaa cgataagtaa agatatcttc ggcgaatgga acgtgatcag agacaaatgg     1200

aacgcggagt atgacgatat tcacctgaag aagaaggctg tcgtaacgga gaagtacgag     1260

gatgatcgca ggaaaagctt caaaaagatc ggaagtttca gcctggaaca gttgcaggag     1320

tatgctgacg ccgatcttag cgtcgtcgag aagttgaagg agataatcat ccaaaaggtc     1380

gacgagatat ataaagtcta tggatcaagt gaaaaactgt tcgacgccga cttcgttttg     1440

gagaagtccc tgaagaagaa cgacgctgtt gttgccatta tgaaggatct gctcgacagc     1500

gtgaagagtt tcgagaacta tattaaggct tttttcgggg aggggaagga gactaacaga     1560

gatgagtcct tctacggaga cttcgtcctc gcgtacgata tactccttaa ggtagaccac     1620

atctacgacg caatcagaaa ttacgtgaca caaaagccgt acagcaagga caagttcaaa     1680

ctctacttcc agaaccccca gttcatgggc ggctgggaca aggacaagga aacggattac     1740

agggctacga tcctgaggta tggttcaaaa tactacttgg cgattatgga caagaagtac     1800

gccaagtgtc tccagaagat tgacaaagac gatgtcaatg gcaattatga gaagatcaac     1860

tacaagctgc ttccgggtcc gaacaagatg ctcccaaagg ttttcttcag caagaaatgg     1920

atggcctact ataacccaag cgaggacatc cagaagattt ataagaacgg tacgttcaag     1980

aagggcgaca tgttcaatct taacgactgt cacaagctga tcgacttctt caaagactca     2040

attagccggt acccaaagtg gtctaacgcc tatgacttca acttttcgga aaccgagaag     2100

tacaaggata tagccggatt ttatagagag gtggaagagc agggctacaa ggtgtcattc     2160

gagtccgcca gcaagaagga agtggacaag ctcgtggaag agggtaagct ctacatgttc     2220

cagatttata ataaagactt tagcgataag agccacggga cacctaatct ccacacaatg     2280

tatttcaagc tgctcttcga cgagaataac cacggccaaa tcaggttgtc aggaggggct     2340

gaactcttca tgcggcgcgc tagccttaag aaggaggagc ttgtagtcca ccctgcgaat     2400

agtccaattg cgaataagaa cccggacaat cctaaaaaga ctacaacatt gagctacgac     2460

gtgtacaagg ataagaggtt ttccgaggat cagtacgagc tccacatccc gattgcgatc     2520

aacaagtgcc caaagaatat tttcaagata aacacagagg tgcgtgtact cctgaagcat     2580

gacgacaatc cttacgtcat tgggattgat cggggcgaga ggaacctcct ctatattgtg     2640

gtggtggacg ggaaggggaa catagtcgaa cagtactccc ttaacgaaat aattaacaat     2700

ttcaacggca tccgtatcaa gaccgactac cattcgttgc tggacaagaa ggagaaggag     2760

agatttgagg cgcggcaaaa ttggacaagt atcgagaaca tcaaggaact caaagcaggt     2820

tatatctctc aagttgtgca taagatatgc gagctggttg agaagtatga cgcagtgatc     2880

gctcttgagg acctcaactc gggctttaag aattctagag ttaaagtgga gaagcaggtc     2940

tatcaaaagt tcgagaagat gcttatagat aagctcaact acatggtcga taagaaatcg     3000

aacccatgtg ccaccggcgg cgcactcaaa ggttaccaaa taacaaacaa attcgagtcc     3060

ttcaaatcga tgagtactca gaatgggttc atattttata taccggcgtg gcttacgtct     3120

aagatcgacc cgtcaactgg ttttgtcaac ctgttgaaga cgaaatacac gtccattgcc     3180

gattcaaaaa agttcatatc tagttttgat cgtattatgt acgtcccaga ggaagatctt     3240

ttcgagtttg ctctcgacta caaaaacttt tcgcgcaccg atgcggatta cattaaaaaa     3300

tggaaactct attcgtacgg caacagaatc aggatttttc gcaaccctaa gaagaataac     3360

gtctttgatt gggaggaagt ttgcttgact agcgcgtaca aggagctctt taataagtat     3420

ggcattaact accaacaggg tgatatcaga gcactgcttt gcgaacaatc tgacaaggct     3480

ttctactcat ccttcatggc tttgatgagc ctgatgctcc agatgagaaa ttcaattaca     3540

ggcagaaccg acgtggattt cttgatctcc ccggttaaaa attctgatgg catcttttac     3600

gatagcagga actatgaagc gcaagagaat gcgattctgc caaaaaatgc agacgccaac     3660

ggtgcctata acatcgccag gaaagtcctg tgggcgatcg gccagttcaa aaaggccgaa     3720

gacgaaaaat tggacaaggt caaaatcgct atcagcaaca aagagtggct ggagtatgct     3780

cagacatccg taaagcatgg cagcccgaag aagaagcgca aggtgtccgg cggcagctcc     3840

ggcggcagcc cgaagaagaa gcgcaaagtg tga                                  3873


<210>  39
<211>  1290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  39

Met Pro Lys Lys Lys Arg Lys Val Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn Cys 
        35                  40                  45              


Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys 
    50                  55                  60                  


Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys 
65                  70                  75                  80  


Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr 
                85                  90                  95      


Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu 
            100                 105                 110         


Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu 
        115                 120                 125             


Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala 
    130                 135                 140                 


Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp 
145                 150                 155                 160 


Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile 
                165                 170                 175     


Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe 
            180                 185                 190         


Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser 
        195                 200                 205             


Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn 
    210                 215                 220                 


Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val 
225                 230                 235                 240 


Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp 
                245                 250                 255     


Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile 
            260                 265                 270         


Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu 
        275                 280                 285             


Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr 
    290                 295                 300                 


Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser 
305                 310                 315                 320 


Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu 
                325                 330                 335     


Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile 
            340                 345                 350         


Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu 
        355                 360                 365             


Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr 
    370                 375                 380                 


Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp 
385                 390                 395                 400 


Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr 
                405                 410                 415     


Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser 
            420                 425                 430         


Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val 
        435                 440                 445             


Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr 
    450                 455                 460                 


Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu 
465                 470                 475                 480 


Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp 
                485                 490                 495     


Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe 
            500                 505                 510         


Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe 
        515                 520                 525             


Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala 
    530                 535                 540                 


Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys 
545                 550                 555                 560 


Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys 
                565                 570                 575     


Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr 
            580                 585                 590         


Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp 
        595                 600                 605             


Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu 
    610                 615                 620                 


Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp 
625                 630                 635                 640 


Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn 
                645                 650                 655     


Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys 
            660                 665                 670         


Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser 
        675                 680                 685             


Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile 
    690                 695                 700                 


Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe 
705                 710                 715                 720 


Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys 
                725                 730                 735     


Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His 
            740                 745                 750         


Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu 
        755                 760                 765             


Asn Asn His Gly Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met 
    770                 775                 780                 


Arg Arg Ala Ser Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn 
785                 790                 795                 800 


Ser Pro Ile Ala Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr 
                805                 810                 815     


Leu Ser Tyr Asp Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr 
            820                 825                 830         


Glu Leu His Ile Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe 
        835                 840                 845             


Lys Ile Asn Thr Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro 
    850                 855                 860                 


Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val 
865                 870                 875                 880 


Val Val Asp Gly Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu 
                885                 890                 895     


Ile Ile Asn Asn Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser 
            900                 905                 910         


Leu Leu Asp Lys Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp 
        915                 920                 925             


Thr Ser Ile Glu Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln 
    930                 935                 940                 


Val Val His Lys Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile 
945                 950                 955                 960 


Ala Leu Glu Asp Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val 
                965                 970                 975     


Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu 
            980                 985                 990         


Asn Tyr Met Val Asp Lys Lys Ser  Asn Pro Cys Ala Thr  Gly Gly Ala 
        995                 1000                 1005             


Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe Glu Ser  Phe Lys Ser 
    1010                 1015                 1020             


Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu 
    1025                 1030                 1035             


Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys 
    1040                 1045                 1050             


Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser 
    1055                 1060                 1065             


Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe 
    1070                 1075                 1080             


Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile 
    1085                 1090                 1095             


Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe 
    1100                 1105                 1110             


Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys 
    1115                 1120                 1125             


Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn 
    1130                 1135                 1140             


Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp 
    1145                 1150                 1155             


Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu Met Ser  Leu Met Leu 
    1160                 1165                 1170             


Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu 
    1175                 1180                 1185             


Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg 
    1190                 1195                 1200             


Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp 
    1205                 1210                 1215             


Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile 
    1220                 1225                 1230             


Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys 
    1235                 1240                 1245             


Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser 
    1250                 1255                 1260             


Val Lys  His Gly Ser Pro Lys  Lys Lys Arg Lys Val  Ser Gly Gly 
    1265                 1270                 1275             


Ser Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1280                 1285                 1290 


<210>  40
<211>  3852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
atggctccta agaagaagcg gaaggttggt attcacgggg tgcctgcggc tctgtttcaa       60

gattttacac atctgtaccc gctgagtaaa acagtgcggt tcgagctgaa acccatagga      120

aggaccctcg agcacatcca cgcgaagaat tttctgagcc aggatgaaac tatggctgat      180

atgtatcaaa aagttaaggt cattttggac gactatcatc gcgattttat tgccgacatg      240

atgggagagg tgaaactcac gaagcttgct gaattttacg acgtctatct gaagttcagg      300

aaaaatccta aggacgatgg gctgcaaaaa cagcttaaag accttcaagc tgtccttcgg      360

aaggaatcgg tgaagcctat agggtcaggt gggaagtaca aaacaggcta cgatagactc      420

tttggggcaa aactcttcaa agatggaaaa gagttgggtg acctcgcaaa attcgttata      480

gcccaagaag gtgagtcttc tccgaagctg gctcatcttg ctcattttga gaagttcagc      540

acgtatttta ctggatttca cgataatcgg aagaatatgt actcggatga agacaagcat      600

actgcaatag cgtacaggct catccatgag aatttgccga gattcatcga caatctgcaa      660

atcttgacaa caatcaaaca aaagcatagc gccctctatg atcagataat caacgagctc      720

acggcctccg ggctcgacgt ctccttggct tctcatcttg acgggtatca caagctcctt      780

acacaagagg ggatcacggc atacaacagg atcataggag aggtgaatgg atatacaaat      840

aagcataacc agatatgcca caagagcgag cgcatagcga aacttagacc cttgcacaag      900

caaatccttt ctgacggaat gggagtgtca ttccttccgt ctaagttcgc ggatgatagt      960

gagatgtgcc aagcggtcaa cgaattttat cgccattata ctgacgtgtt cgcaaaggtg     1020

caaagtctct ttgacggatt tgatgatcac cagaaagacg ggatctatgt tgaacacaaa     1080

aaccttaatg aactgagcaa acaggcgttc ggcgactttg ctttgctggg gagggtcctt     1140

gatggatact acgtggacgt tgtcaatccg gagttcaatg agcggttcgc aaaggccaag     1200

actgacaatg cgaaagccaa gcttacaaaa gaaaaggaca aattcattaa aggagtccac     1260

tcactggctt ccctcgaaca agcaatagaa caccatacag ctagacacga cgatgagagt     1320

gttcaagccg gaaaacttgg ccagtacttc aaacacggtt tggcgggggt tgacaacccg     1380

attcagaaaa ttcacaataa ccattcgacg attaaagggt ttctggaaag ggaaaggcct     1440

gctggggaac gggcgctccc gaagatcaag tcaggaaaaa acccagaaat gacacagctc     1500

aggcagctga aggaactttt ggacaacgca ttgaatgtgg cgcacttcgc taagctgctg     1560

acaactaaaa caaccttgga caaccaggat ggaaattttt acggggagtt tggggtgctt     1620

tacgacgagc tggctaaaat tccaactctc tacaataagg ttagagatta tctctctcaa     1680

aagccctttt ctaccgaaaa gtataagctc aacttcggca atccgaccct tctcaatggg     1740

tgggacctga acaaagagaa agataacttt ggggttatac ttcagaagga tggatgctat     1800

tacttggcgc ttcttgataa ggctcataaa aaagttttcg acaacgcccc taacactggt     1860

aagaacgtct accaaaagat ggtctacaaa ctgttgcccg gccccaacaa aatgcttcct     1920

aaagtgtttt tcgcaaaatc gaatctcgac tattataatc catctgccga gctccttgac     1980

aaatatgcta aggggaccca taaaaagggt gataatttca acctgaagga ctgccacgcg     2040

cttatcgact ttttcaaagc cgggataaat aagcatccgg agtggcaaca ttttggtttt     2100

aaattttcgc caacgtcgtc ctatcgcgac ctttccgatt tctataggga agttgaacct     2160

caggggtacc aggtcaaatt tgttgacatt aatgcggact acattgatga attggtggag     2220

caagggaagc tctacctctt tcaaatatat aacaaagatt tctcgccaaa agcgcatggt     2280

aaaccgaatc ttcatacctt gtactttaaa gcactttttt cagaagataa cttggcggac     2340

ccgatctaca agctgaatgg ggaagctcag atcttctaca ggaaagcttc gttggacatg     2400

aacgagacta ccatacatcg cgcgggagag gtgcttgaga acaaaaatcc cgacaacccg     2460

aaaaagcggc aattcgttta cgacatcatc aaagacaaac ggtacacgca ggacaaattt     2520

atgctccacg tccccattac catgaatttt ggagtccaag gcatgaccat taaggaattc     2580

aacaaaaagg tcaaccaaag tattcagcaa tacgatgaag tcaatgtcat aggcatagat     2640

cggggagaaa ggcatctgtt gtatcttacc gtgattaact ctaagggtga aatactggag     2700

caacggtcac ttaacgatat aaccacggcg tccgcgaacg gtacacaagt gaccactccc     2760

taccacaaaa tattggataa aagggagata gaacgcttga atgcccgcgt tggctggggt     2820

gagattgaga ccatcaaaga gcttaaatcg ggatatttgt ctcacgtcgt tcatcaaatt     2880

aaccaactca tgcttaagta caatgcaatc gttgtgctcg aggacctgaa ctttggtttc     2940

aaaagaggga ggttcaaggt ggaaaaacaa atttaccaga actttgaaaa cgcgcttatc     3000

aagaaattga atcaccttgt tttgaaagat aaggcagatg acgaaatcgg gtcgtataaa     3060

aatgcactcc agttgacaaa taatttcacg gatttgaagt cgatcggcaa gcaaacaggg     3120

ttcctctttt atgtgccagc gtggaataca tcaaaaattg atccggagac gggatttgtc     3180

gacttgctga agcctaggta tgagaacatt gcccaatctc aggccttttt cggcaaattc     3240

gataaaatat gctacaacac agacaaaggt tattttgaat ttcacattga ttacgccaaa     3300

tttacagata aggcgaaaaa cagcagacag aaatgggcta tctgttctca tggggacaaa     3360

cgctatgtct acgataagac ggctaatcaa aataaaggcg ccgcaaaagg tattaatgtg     3420

aatgatgagc tgaaaagctt gtttgcccgc taccatatca atgataaaca accaaacttg     3480

gtgatggaca tatgccagaa caatgacaaa gaattccaca agtcactcat gtgcctgctt     3540

aaaacccttt tggcgctgcg gtatagcaat gcatctagcg atgaagactt tattttgagt     3600

cccgtggcca acgacgaggg cgtgtttttt aattcagcct tggcggacga tacgcagccc     3660

cagaatgcgg acgcaaacgg cgcgtaccac attgcactga agggactgtg gcttctgaac     3720

gagctgaaaa atagcgacga cctgaataaa gtcaagttgg ccattgacaa tcaaacctgg     3780

ttgaatttcg ctcaaaatag aaagcgtcct gctgccacca aaaaggccgg acaggctaag     3840

aaaaagaagt ga                                                         3852


<210>  41
<211>  1283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  41

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val 
            20                  25                  30          


Arg Phe Glu Leu Lys Pro Ile Gly Arg Thr Leu Glu His Ile His Ala 
        35                  40                  45              


Lys Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp Met Tyr Gln Lys 
    50                  55                  60                  


Val Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met 
65                  70                  75                  80  


Met Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr 
                85                  90                  95      


Leu Lys Phe Arg Lys Asn Pro Lys Asp Asp Gly Leu Gln Lys Gln Leu 
            100                 105                 110         


Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ser Val Lys Pro Ile Gly 
        115                 120                 125             


Ser Gly Gly Lys Tyr Lys Thr Gly Tyr Asp Arg Leu Phe Gly Ala Lys 
    130                 135                 140                 


Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile 
145                 150                 155                 160 


Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His Leu Ala His Phe 
                165                 170                 175     


Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn 
            180                 185                 190         


Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile 
        195                 200                 205             


His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr 
    210                 215                 220                 


Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu 
225                 230                 235                 240 


Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr 
                245                 250                 255     


His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr Asn Arg Ile Ile 
            260                 265                 270         


Gly Glu Val Asn Gly Tyr Thr Asn Lys His Asn Gln Ile Cys His Lys 
        275                 280                 285             


Ser Glu Arg Ile Ala Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser 
    290                 295                 300                 


Asp Gly Met Gly Val Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser 
305                 310                 315                 320 


Glu Met Cys Gln Ala Val Asn Glu Phe Tyr Arg His Tyr Thr Asp Val 
                325                 330                 335     


Phe Ala Lys Val Gln Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys 
            340                 345                 350         


Asp Gly Ile Tyr Val Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln 
        355                 360                 365             


Ala Phe Gly Asp Phe Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr 
    370                 375                 380                 


Val Asp Val Val Asn Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys 
385                 390                 395                 400 


Thr Asp Asn Ala Lys Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile 
                405                 410                 415     


Lys Gly Val His Ser Leu Ala Ser Leu Glu Gln Ala Ile Glu His His 
            420                 425                 430         


Thr Ala Arg His Asp Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln 
        435                 440                 445             


Tyr Phe Lys His Gly Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile 
    450                 455                 460                 


His Asn Asn His Ser Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Ala Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu 
                485                 490                 495     


Met Thr Gln Leu Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn 
            500                 505                 510         


Val Ala His Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn 
        515                 520                 525             


Gln Asp Gly Asn Phe Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu 
    530                 535                 540                 


Ala Lys Ile Pro Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln 
545                 550                 555                 560 


Lys Pro Phe Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr 
                565                 570                 575     


Leu Leu Asn Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val 
            580                 585                 590         


Ile Leu Gln Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala 
        595                 600                 605             


His Lys Lys Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Asn Val Tyr 
    610                 615                 620                 


Gln Lys Met Val Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro 
625                 630                 635                 640 


Lys Val Phe Phe Ala Lys Ser Asn Leu Asp Tyr Tyr Asn Pro Ser Ala 
                645                 650                 655     


Glu Leu Leu Asp Lys Tyr Ala Lys Gly Thr His Lys Lys Gly Asp Asn 
            660                 665                 670         


Phe Asn Leu Lys Asp Cys His Ala Leu Ile Asp Phe Phe Lys Ala Gly 
        675                 680                 685             


Ile Asn Lys His Pro Glu Trp Gln His Phe Gly Phe Lys Phe Ser Pro 
    690                 695                 700                 


Thr Ser Ser Tyr Arg Asp Leu Ser Asp Phe Tyr Arg Glu Val Glu Pro 
705                 710                 715                 720 


Gln Gly Tyr Gln Val Lys Phe Val Asp Ile Asn Ala Asp Tyr Ile Asp 
                725                 730                 735     


Glu Leu Val Glu Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
            740                 745                 750         


Asp Phe Ser Pro Lys Ala His Gly Lys Pro Asn Leu His Thr Leu Tyr 
        755                 760                 765             


Phe Lys Ala Leu Phe Ser Glu Asp Asn Leu Ala Asp Pro Ile Tyr Lys 
    770                 775                 780                 


Leu Asn Gly Glu Ala Gln Ile Phe Tyr Arg Lys Ala Ser Leu Asp Met 
785                 790                 795                 800 


Asn Glu Thr Thr Ile His Arg Ala Gly Glu Val Leu Glu Asn Lys Asn 
                805                 810                 815     


Pro Asp Asn Pro Lys Lys Arg Gln Phe Val Tyr Asp Ile Ile Lys Asp 
            820                 825                 830         


Lys Arg Tyr Thr Gln Asp Lys Phe Met Leu His Val Pro Ile Thr Met 
        835                 840                 845             


Asn Phe Gly Val Gln Gly Met Thr Ile Lys Glu Phe Asn Lys Lys Val 
    850                 855                 860                 


Asn Gln Ser Ile Gln Gln Tyr Asp Glu Val Asn Val Ile Gly Ile Asp 
865                 870                 875                 880 


Arg Gly Glu Arg His Leu Leu Tyr Leu Thr Val Ile Asn Ser Lys Gly 
                885                 890                 895     


Glu Ile Leu Glu Gln Arg Ser Leu Asn Asp Ile Thr Thr Ala Ser Ala 
            900                 905                 910         


Asn Gly Thr Gln Val Thr Thr Pro Tyr His Lys Ile Leu Asp Lys Arg 
        915                 920                 925             


Glu Ile Glu Arg Leu Asn Ala Arg Val Gly Trp Gly Glu Ile Glu Thr 
    930                 935                 940                 


Ile Lys Glu Leu Lys Ser Gly Tyr Leu Ser His Val Val His Gln Ile 
945                 950                 955                 960 


Asn Gln Leu Met Leu Lys Tyr Asn Ala Ile Val Val Leu Glu Asp Leu 
                965                 970                 975     


Asn Phe Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln Ile Tyr 
            980                 985                 990         


Gln Asn Phe Glu Asn Ala Leu Ile  Lys Lys Leu Asn His  Leu Val Leu 
        995                 1000                 1005             


Lys Asp  Lys Ala Asp Asp Glu  Ile Gly Ser Tyr Lys  Asn Ala Leu 
    1010                 1015                 1020             


Gln Leu  Thr Asn Asn Phe Thr  Asp Leu Lys Ser Ile  Gly Lys Gln 
    1025                 1030                 1035             


Thr Gly  Phe Leu Phe Tyr Val  Pro Ala Trp Asn Thr  Ser Lys Ile 
    1040                 1045                 1050             


Asp Pro  Glu Thr Gly Phe Val  Asp Leu Leu Lys Pro  Arg Tyr Glu 
    1055                 1060                 1065             


Asn Ile  Ala Gln Ser Gln Ala  Phe Phe Gly Lys Phe  Asp Lys Ile 
    1070                 1075                 1080             


Cys Tyr  Asn Thr Asp Lys Gly  Tyr Phe Glu Phe His  Ile Asp Tyr 
    1085                 1090                 1095             


Ala Lys  Phe Thr Asp Lys Ala  Lys Asn Ser Arg Gln  Lys Trp Ala 
    1100                 1105                 1110             


Ile Cys  Ser His Gly Asp Lys  Arg Tyr Val Tyr Asp  Lys Thr Ala 
    1115                 1120                 1125             


Asn Gln  Asn Lys Gly Ala Ala  Lys Gly Ile Asn Val  Asn Asp Glu 
    1130                 1135                 1140             


Leu Lys  Ser Leu Phe Ala Arg  Tyr His Ile Asn Asp  Lys Gln Pro 
    1145                 1150                 1155             


Asn Leu  Val Met Asp Ile Cys  Gln Asn Asn Asp Lys  Glu Phe His 
    1160                 1165                 1170             


Lys Ser  Leu Met Cys Leu Leu  Lys Thr Leu Leu Ala  Leu Arg Tyr 
    1175                 1180                 1185             


Ser Asn  Ala Ser Ser Asp Glu  Asp Phe Ile Leu Ser  Pro Val Ala 
    1190                 1195                 1200             


Asn Asp  Glu Gly Val Phe Phe  Asn Ser Ala Leu Ala  Asp Asp Thr 
    1205                 1210                 1215             


Gln Pro  Gln Asn Ala Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu 
    1220                 1225                 1230             


Lys Gly  Leu Trp Leu Leu Asn  Glu Leu Lys Asn Ser  Asp Asp Leu 
    1235                 1240                 1245             


Asn Lys  Val Lys Leu Ala Ile  Asp Asn Gln Thr Trp  Leu Asn Phe 
    1250                 1255                 1260             


Ala Gln  Asn Arg Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1265                 1270                 1275             


Ala Lys  Lys Lys Lys 
    1280             


<210>  42
<211>  3936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
atgccgaaga agaagcgcaa ggtcgggggc gggggctcag gcgggggcgg gagcggcggc       60

gggggctctg ggggcggcgg cagcggcggg ggcggcagcg ggggcggcgg gtcgatgctg      120

ttccaggatt tcactcatct gtaccctctc tcaaagactg ttcggttcga gctcaagcct      180

attgggcgga ctctggagca catccacgcg aagaacttcc tcagccagga cgaaaccatg      240

gccgacatgt accagaaggt caaggtcatc ctcgacgact accacaggga cttcatcgcg      300

gacatgatgg gcgaggtgaa gctgacgaag ctcgccgagt tctacgacgt ctacctcaag      360

ttccgcaaga acccgaagga cgacggcctc cagaagcagc tcaaggacct gcaggccgtc      420

ctgaggaagg agtccgtcaa gcccatcggc agcggcggca agtacaagac cggctacgac      480

aggctgttcg gcgccaagct gttcaaggac ggcaaggagc tcggcgacct ggcgaagttc      540

gtgatcgcgc aggagggcga gagctccccc aagctggccc acctggccca cttcgagaag      600

ttcagcacgt acttcaccgg cttccacgac aacaggaaga acatgtacag cgacgaggac      660

aagcacacgg ccatcgccta ccgcctcatc cacgagaacc tgccccgctt catcgacaac      720

ctgcagatcc tgacgaccat caagcagaag cactccgccc tgtacgacca gatcatcaac      780

gagctcaccg cgagcggcct cgacgtgtcc ctcgccagcc acctcgacgg ctaccacaag      840

ctcctgaccc aggagggcat caccgcctac aaccgcatca tcggcgaggt gaacggctac      900

accaacaagc acaaccagat ctgccacaag tccgagagga tcgccaagct caggcccctg      960

cacaagcaga tcctcagcga cggcatgggc gtgagcttcc tcccgtccaa gttcgccgac     1020

gactccgaga tgtgccaggc cgtgaacgag ttctacaggc actacaccga cgtgttcgcc     1080

aaggtgcagt ccctgttcga cggcttcgac gaccaccaga aggacggcat ctacgtggag     1140

cacaagaacc tgaacgagct gtccaagcag gccttcggcg acttcgccct cctgggccgc     1200

gtgctggacg gctactacgt ggacgtcgtg aacccggagt tcaacgagcg cttcgcgaag     1260

gcgaagacgg acaacgcgaa ggccaagctc accaaggaga aggacaagtt catcaagggc     1320

gtccacagcc tcgcgtccct ggagcaggcg atcgagcacc acaccgcgcg ccacgacgac     1380

gagtccgtgc aggccggcaa gctcggccag tacttcaagc acggcctggc cggcgtcgac     1440

aacccgatcc agaagatcca caacaaccac tccaccatca agggcttcct ggagagggag     1500

cgcccggcgg gcgagcgcgc gctccccaag atcaagtccg gcaagaaccc cgagatgacg     1560

cagctcaggc agctgaagga gctgctcgac aacgcgctca acgtggcgca cttcgccaag     1620

ctgctcacga ccaagaccac gctggacaac caggacggca acttctacgg cgagttcggc     1680

gtcctgtacg acgagctggc gaagatcccg accctgtaca acaaggtccg cgactacctg     1740

agccagaagc ccttctccac cgagaagtac aagctcaact tcggcaaccc gaccctcctg     1800

aacggctggg acctcaacaa ggagaaggac aacttcggcg tgatcctcca gaaggacggc     1860

tgctactacc tcgccctgct ggacaaggcg cacaagaagg tcttcgacaa cgccccgaac     1920

accggcaaga acgtgtacca gaagatggtg tacaagctgc tccccggccc caacaagatg     1980

ctgccgaagg tgttcttcgc gaagtccaac ctcgactact acaaccccag cgccgagctc     2040

ctggacaagt acgccaaggg cacgcacaag aagggcgaca acttcaacct caaggactgc     2100

cacgcgctga tcgacttctt caaggcgggc atcaacaagc accccgagtg gcagcacttc     2160

ggcttcaagt tcagcccgac ctccagctac agggacctca gcgacttcta ccgcgaggtg     2220

gagccccagg gctaccaggt gaagttcgtc gacatcaacg ccgactacat cgacgagctc     2280

gtcgagcagg gcaagctcta cctgttccag atctacaaca aggacttctc cccgaaggcc     2340

cacggcaagc cgaacctcca cacgctctac ttcaaggccc tcttcagcga ggacaacctg     2400

gccgacccga tctacaagct caacggcgag gcgcagatct tctaccgcaa ggccagcctg     2460

gacatgaacg aaacgaccat ccacagggcc ggcgaggtcc tggagaacaa gaacccggac     2520

aacccgaaga agaggcagtt cgtctacgac atcatcaagg acaagaggta cacccaggac     2580

aagttcatgc tccacgtccc gatcaccatg aacttcggcg tccagggcat gaccatcaag     2640

gagttcaaca agaaggtcaa ccagagcatc cagcagtacg acgaggtgaa cgtcatcggc     2700

atcgaccgcg gcgagaggca cctgctctac ctgacggtca tcaactccaa gggcgagatc     2760

ctcgagcagc gcagcctgaa cgacatcacg accgcgagcg ccaacggcac gcaggtcacc     2820

acgccgtacc acaagatcct cgacaagcgc gagatcgaga ggctgaacgc gcgcgtcggc     2880

tggggcgaga tcgaaacgat caaggagctc aagtccggct acctcagcca cgtcgtgcac     2940

cagatcaacc agctcatgct gaagtacaac gcgatcgtgg tcctcgagga cctgaacttc     3000

ggcttcaaga ggggccgctt caaggtggag aagcagatct accagaactt cgagaacgcc     3060

ctgatcaaga agctcaacca cctggtcctc aaggacaagg cggacgacga gatcggcagc     3120

tacaagaacg cgctccagct gaccaacaac ttcacggacc tcaagtccat cggcaagcag     3180

acgggcttcc tgttctacgt gccggcgtgg aacacctcca agatcgaccc ggaaaccggc     3240

ttcgtcgacc tgctcaagcc gcgctacgag aacatcgcgc agtcccaggc gttcttcggc     3300

aagttcgaca agatctgcta caacaccgac aagggctact tcgagttcca catcgactac     3360

gcgaagttca ccgacaaggc caagaactcc aggcagaagt gggccatctg cagccacggc     3420

gacaagcgct acgtgtacga caagacggcg aaccagaaca agggcgcggc caagggcatc     3480

aacgtgaacg acgagctgaa gtccctcttc gcgcgctacc acatcaacga caagcagccg     3540

aacctcgtca tggacatctg ccagaacaac gacaaggagt tccacaagag cctgatgtgc     3600

ctgctcaaga ccctgctcgc cctccgctac tccaacgcga gctccgacga ggacttcatc     3660

ctcagccccg tcgcgaacga cgagggcgtg ttcttcaact ccgccctcgc ggacgacacg     3720

cagccgcaga acgccgacgc gaacggcgcc taccacatcg ccctcaaggg cctgtggctg     3780

ctcaacgagc tcaagaactc cgacgacctg aacaaggtga agctcgccat tgacaaccag     3840

acgtggctga atttcgctca gaataggccg aagaagaagc gcaaggtgtc cggcggcagc     3900

tccggcggca gcccgaagaa gaagcgcaaa gtgtga                               3936


<210>  43
<211>  1311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  43

Met Pro Lys Lys Lys Arg Lys Val Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Met Leu Phe Gln Asp Phe Thr His Leu Tyr 
        35                  40                  45              


Pro Leu Ser Lys Thr Val Arg Phe Glu Leu Lys Pro Ile Gly Arg Thr 
    50                  55                  60                  


Leu Glu His Ile His Ala Lys Asn Phe Leu Ser Gln Asp Glu Thr Met 
65                  70                  75                  80  


Ala Asp Met Tyr Gln Lys Val Lys Val Ile Leu Asp Asp Tyr His Arg 
                85                  90                  95      


Asp Phe Ile Ala Asp Met Met Gly Glu Val Lys Leu Thr Lys Leu Ala 
            100                 105                 110         


Glu Phe Tyr Asp Val Tyr Leu Lys Phe Arg Lys Asn Pro Lys Asp Asp 
        115                 120                 125             


Gly Leu Gln Lys Gln Leu Lys Asp Leu Gln Ala Val Leu Arg Lys Glu 
    130                 135                 140                 


Ser Val Lys Pro Ile Gly Ser Gly Gly Lys Tyr Lys Thr Gly Tyr Asp 
145                 150                 155                 160 


Arg Leu Phe Gly Ala Lys Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp 
                165                 170                 175     


Leu Ala Lys Phe Val Ile Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu 
            180                 185                 190         


Ala His Leu Ala His Phe Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe 
        195                 200                 205             


His Asp Asn Arg Lys Asn Met Tyr Ser Asp Glu Asp Lys His Thr Ala 
    210                 215                 220                 


Ile Ala Tyr Arg Leu Ile His Glu Asn Leu Pro Arg Phe Ile Asp Asn 
225                 230                 235                 240 


Leu Gln Ile Leu Thr Thr Ile Lys Gln Lys His Ser Ala Leu Tyr Asp 
                245                 250                 255     


Gln Ile Ile Asn Glu Leu Thr Ala Ser Gly Leu Asp Val Ser Leu Ala 
            260                 265                 270         


Ser His Leu Asp Gly Tyr His Lys Leu Leu Thr Gln Glu Gly Ile Thr 
        275                 280                 285             


Ala Tyr Asn Arg Ile Ile Gly Glu Val Asn Gly Tyr Thr Asn Lys His 
    290                 295                 300                 


Asn Gln Ile Cys His Lys Ser Glu Arg Ile Ala Lys Leu Arg Pro Leu 
305                 310                 315                 320 


His Lys Gln Ile Leu Ser Asp Gly Met Gly Val Ser Phe Leu Pro Ser 
                325                 330                 335     


Lys Phe Ala Asp Asp Ser Glu Met Cys Gln Ala Val Asn Glu Phe Tyr 
            340                 345                 350         


Arg His Tyr Thr Asp Val Phe Ala Lys Val Gln Ser Leu Phe Asp Gly 
        355                 360                 365             


Phe Asp Asp His Gln Lys Asp Gly Ile Tyr Val Glu His Lys Asn Leu 
    370                 375                 380                 


Asn Glu Leu Ser Lys Gln Ala Phe Gly Asp Phe Ala Leu Leu Gly Arg 
385                 390                 395                 400 


Val Leu Asp Gly Tyr Tyr Val Asp Val Val Asn Pro Glu Phe Asn Glu 
                405                 410                 415     


Arg Phe Ala Lys Ala Lys Thr Asp Asn Ala Lys Ala Lys Leu Thr Lys 
            420                 425                 430         


Glu Lys Asp Lys Phe Ile Lys Gly Val His Ser Leu Ala Ser Leu Glu 
        435                 440                 445             


Gln Ala Ile Glu His His Thr Ala Arg His Asp Asp Glu Ser Val Gln 
    450                 455                 460                 


Ala Gly Lys Leu Gly Gln Tyr Phe Lys His Gly Leu Ala Gly Val Asp 
465                 470                 475                 480 


Asn Pro Ile Gln Lys Ile His Asn Asn His Ser Thr Ile Lys Gly Phe 
                485                 490                 495     


Leu Glu Arg Glu Arg Pro Ala Gly Glu Arg Ala Leu Pro Lys Ile Lys 
            500                 505                 510         


Ser Gly Lys Asn Pro Glu Met Thr Gln Leu Arg Gln Leu Lys Glu Leu 
        515                 520                 525             


Leu Asp Asn Ala Leu Asn Val Ala His Phe Ala Lys Leu Leu Thr Thr 
    530                 535                 540                 


Lys Thr Thr Leu Asp Asn Gln Asp Gly Asn Phe Tyr Gly Glu Phe Gly 
545                 550                 555                 560 


Val Leu Tyr Asp Glu Leu Ala Lys Ile Pro Thr Leu Tyr Asn Lys Val 
                565                 570                 575     


Arg Asp Tyr Leu Ser Gln Lys Pro Phe Ser Thr Glu Lys Tyr Lys Leu 
            580                 585                 590         


Asn Phe Gly Asn Pro Thr Leu Leu Asn Gly Trp Asp Leu Asn Lys Glu 
        595                 600                 605             


Lys Asp Asn Phe Gly Val Ile Leu Gln Lys Asp Gly Cys Tyr Tyr Leu 
    610                 615                 620                 


Ala Leu Leu Asp Lys Ala His Lys Lys Val Phe Asp Asn Ala Pro Asn 
625                 630                 635                 640 


Thr Gly Lys Asn Val Tyr Gln Lys Met Val Tyr Lys Leu Leu Pro Gly 
                645                 650                 655     


Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ala Lys Ser Asn Leu Asp 
            660                 665                 670         


Tyr Tyr Asn Pro Ser Ala Glu Leu Leu Asp Lys Tyr Ala Lys Gly Thr 
        675                 680                 685             


His Lys Lys Gly Asp Asn Phe Asn Leu Lys Asp Cys His Ala Leu Ile 
    690                 695                 700                 


Asp Phe Phe Lys Ala Gly Ile Asn Lys His Pro Glu Trp Gln His Phe 
705                 710                 715                 720 


Gly Phe Lys Phe Ser Pro Thr Ser Ser Tyr Arg Asp Leu Ser Asp Phe 
                725                 730                 735     


Tyr Arg Glu Val Glu Pro Gln Gly Tyr Gln Val Lys Phe Val Asp Ile 
            740                 745                 750         


Asn Ala Asp Tyr Ile Asp Glu Leu Val Glu Gln Gly Lys Leu Tyr Leu 
        755                 760                 765             


Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Lys Ala His Gly Lys Pro 
    770                 775                 780                 


Asn Leu His Thr Leu Tyr Phe Lys Ala Leu Phe Ser Glu Asp Asn Leu 
785                 790                 795                 800 


Ala Asp Pro Ile Tyr Lys Leu Asn Gly Glu Ala Gln Ile Phe Tyr Arg 
                805                 810                 815     


Lys Ala Ser Leu Asp Met Asn Glu Thr Thr Ile His Arg Ala Gly Glu 
            820                 825                 830         


Val Leu Glu Asn Lys Asn Pro Asp Asn Pro Lys Lys Arg Gln Phe Val 
        835                 840                 845             


Tyr Asp Ile Ile Lys Asp Lys Arg Tyr Thr Gln Asp Lys Phe Met Leu 
    850                 855                 860                 


His Val Pro Ile Thr Met Asn Phe Gly Val Gln Gly Met Thr Ile Lys 
865                 870                 875                 880 


Glu Phe Asn Lys Lys Val Asn Gln Ser Ile Gln Gln Tyr Asp Glu Val 
                885                 890                 895     


Asn Val Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Thr 
            900                 905                 910         


Val Ile Asn Ser Lys Gly Glu Ile Leu Glu Gln Arg Ser Leu Asn Asp 
        915                 920                 925             


Ile Thr Thr Ala Ser Ala Asn Gly Thr Gln Val Thr Thr Pro Tyr His 
    930                 935                 940                 


Lys Ile Leu Asp Lys Arg Glu Ile Glu Arg Leu Asn Ala Arg Val Gly 
945                 950                 955                 960 


Trp Gly Glu Ile Glu Thr Ile Lys Glu Leu Lys Ser Gly Tyr Leu Ser 
                965                 970                 975     


His Val Val His Gln Ile Asn Gln Leu Met Leu Lys Tyr Asn Ala Ile 
            980                 985                 990         


Val Val Leu Glu Asp Leu Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys 
        995                 1000                 1005             


Val Glu  Lys Gln Ile Tyr Gln  Asn Phe Glu Asn Ala  Leu Ile Lys 
    1010                 1015                 1020             


Lys Leu  Asn His Leu Val Leu  Lys Asp Lys Ala Asp  Asp Glu Ile 
    1025                 1030                 1035             


Gly Ser  Tyr Lys Asn Ala Leu  Gln Leu Thr Asn Asn  Phe Thr Asp 
    1040                 1045                 1050             


Leu Lys  Ser Ile Gly Lys Gln  Thr Gly Phe Leu Phe  Tyr Val Pro 
    1055                 1060                 1065             


Ala Trp  Asn Thr Ser Lys Ile  Asp Pro Glu Thr Gly  Phe Val Asp 
    1070                 1075                 1080             


Leu Leu  Lys Pro Arg Tyr Glu  Asn Ile Ala Gln Ser  Gln Ala Phe 
    1085                 1090                 1095             


Phe Gly  Lys Phe Asp Lys Ile  Cys Tyr Asn Thr Asp  Lys Gly Tyr 
    1100                 1105                 1110             


Phe Glu  Phe His Ile Asp Tyr  Ala Lys Phe Thr Asp  Lys Ala Lys 
    1115                 1120                 1125             


Asn Ser  Arg Gln Lys Trp Ala  Ile Cys Ser His Gly  Asp Lys Arg 
    1130                 1135                 1140             


Tyr Val  Tyr Asp Lys Thr Ala  Asn Gln Asn Lys Gly  Ala Ala Lys 
    1145                 1150                 1155             


Gly Ile  Asn Val Asn Asp Glu  Leu Lys Ser Leu Phe  Ala Arg Tyr 
    1160                 1165                 1170             


His Ile  Asn Asp Lys Gln Pro  Asn Leu Val Met Asp  Ile Cys Gln 
    1175                 1180                 1185             


Asn Asn  Asp Lys Glu Phe His  Lys Ser Leu Met Cys  Leu Leu Lys 
    1190                 1195                 1200             


Thr Leu  Leu Ala Leu Arg Tyr  Ser Asn Ala Ser Ser  Asp Glu Asp 
    1205                 1210                 1215             


Phe Ile  Leu Ser Pro Val Ala  Asn Asp Glu Gly Val  Phe Phe Asn 
    1220                 1225                 1230             


Ser Ala  Leu Ala Asp Asp Thr  Gln Pro Gln Asn Ala  Asp Ala Asn 
    1235                 1240                 1245             


Gly Ala  Tyr His Ile Ala Leu  Lys Gly Leu Trp Leu  Leu Asn Glu 
    1250                 1255                 1260             


Leu Lys  Asn Ser Asp Asp Leu  Asn Lys Val Lys Leu  Ala Ile Asp 
    1265                 1270                 1275             


Asn Gln  Thr Trp Leu Asn Phe  Ala Gln Asn Arg Pro  Lys Lys Lys 
    1280                 1285                 1290             


Arg Lys  Val Ser Gly Gly Ser  Ser Gly Gly Ser Pro  Lys Lys Lys 
    1295                 1300                 1305             


Arg Lys  Val 
    1310     


<210>  44
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly 
        35      


<210>  45
<211>  1260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  xNLS-03
<222>  (1)..(9)

<220>
<221>  xEpitope-03
<222>  (10)..(17)

<220>
<221>  xNLS-04
<222>  (1245)..(1260)

<400>  45

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
            20                  25                  30          


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
        35                  40                  45              


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
    50                  55                  60                  


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
65                  70                  75                  80  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
                85                  90                  95      


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
            100                 105                 110         


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
        115                 120                 125             


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
    130                 135                 140                 


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
145                 150                 155                 160 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
                165                 170                 175     


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
            180                 185                 190         


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
        195                 200                 205             


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
    210                 215                 220                 


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
225                 230                 235                 240 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
                245                 250                 255     


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
            260                 265                 270         


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
        275                 280                 285             


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
    290                 295                 300                 


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
305                 310                 315                 320 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
                325                 330                 335     


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
            340                 345                 350         


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
        355                 360                 365             


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
    370                 375                 380                 


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
385                 390                 395                 400 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
                405                 410                 415     


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
            420                 425                 430         


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
        435                 440                 445             


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
    450                 455                 460                 


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
465                 470                 475                 480 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
                485                 490                 495     


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
            500                 505                 510         


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
        515                 520                 525             


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
    530                 535                 540                 


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
545                 550                 555                 560 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
                565                 570                 575     


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
            580                 585                 590         


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
        595                 600                 605             


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
    610                 615                 620                 


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
625                 630                 635                 640 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
                645                 650                 655     


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
            660                 665                 670         


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
        675                 680                 685             


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
    690                 695                 700                 


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
705                 710                 715                 720 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
                725                 730                 735     


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
            740                 745                 750         


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
        755                 760                 765             


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
    770                 775                 780                 


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
785                 790                 795                 800 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
                805                 810                 815     


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
            820                 825                 830         


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
        835                 840                 845             


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
    850                 855                 860                 


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
865                 870                 875                 880 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
                885                 890                 895     


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
            900                 905                 910         


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
        915                 920                 925             


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
    930                 935                 940                 


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
945                 950                 955                 960 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
                965                 970                 975     


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
            980                 985                 990         


Thr Asn Lys Phe Glu Ser Phe Lys  Ser Met Ser Thr Gln  Asn Gly Phe 
        995                 1000                 1005             


Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
    1010                 1015                 1020             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1025                 1030                 1035             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1040                 1045                 1050             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1055                 1060                 1065             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1070                 1075                 1080             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1085                 1090                 1095             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1100                 1105                 1110             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1115                 1120                 1125             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1130                 1135                 1140             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1145                 1150                 1155             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1160                 1165                 1170             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1175                 1180                 1185             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1190                 1195                 1200             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1205                 1210                 1215             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1220                 1225                 1230             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Lys  Arg Pro Ala 
    1235                 1240                 1245             


Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys Lys Lys  
    1250                 1255                 1260 


<210>  46
<211>  1283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  xNLS-03
<222>  (1)..(9)

<220>
<221>  xEpitope-03
<222>  (10)..(17)

<220>
<221>  xNLS-04
<222>  (1268)..(1283)

<400>  46

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val 
            20                  25                  30          


Arg Phe Glu Leu Lys Pro Ile Gly Arg Thr Leu Glu His Ile His Ala 
        35                  40                  45              


Lys Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp Met Tyr Gln Lys 
    50                  55                  60                  


Val Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met 
65                  70                  75                  80  


Met Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr 
                85                  90                  95      


Leu Lys Phe Arg Lys Asn Pro Lys Asp Asp Gly Leu Gln Lys Gln Leu 
            100                 105                 110         


Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ser Val Lys Pro Ile Gly 
        115                 120                 125             


Ser Gly Gly Lys Tyr Lys Thr Gly Tyr Asp Arg Leu Phe Gly Ala Lys 
    130                 135                 140                 


Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile 
145                 150                 155                 160 


Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His Leu Ala His Phe 
                165                 170                 175     


Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn 
            180                 185                 190         


Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile 
        195                 200                 205             


His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr 
    210                 215                 220                 


Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu 
225                 230                 235                 240 


Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr 
                245                 250                 255     


His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr Asn Arg Ile Ile 
            260                 265                 270         


Gly Glu Val Asn Gly Tyr Thr Asn Lys His Asn Gln Ile Cys His Lys 
        275                 280                 285             


Ser Glu Arg Ile Ala Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser 
    290                 295                 300                 


Asp Gly Met Gly Val Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser 
305                 310                 315                 320 


Glu Met Cys Gln Ala Val Asn Glu Phe Tyr Arg His Tyr Thr Asp Val 
                325                 330                 335     


Phe Ala Lys Val Gln Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys 
            340                 345                 350         


Asp Gly Ile Tyr Val Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln 
        355                 360                 365             


Ala Phe Gly Asp Phe Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr 
    370                 375                 380                 


Val Asp Val Val Asn Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys 
385                 390                 395                 400 


Thr Asp Asn Ala Lys Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile 
                405                 410                 415     


Lys Gly Val His Ser Leu Ala Ser Leu Glu Gln Ala Ile Glu His His 
            420                 425                 430         


Thr Ala Arg His Asp Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln 
        435                 440                 445             


Tyr Phe Lys His Gly Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile 
    450                 455                 460                 


His Asn Asn His Ser Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Ala Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu 
                485                 490                 495     


Met Thr Gln Leu Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn 
            500                 505                 510         


Val Ala His Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn 
        515                 520                 525             


Gln Asp Gly Asn Phe Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu 
    530                 535                 540                 


Ala Lys Ile Pro Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln 
545                 550                 555                 560 


Lys Pro Phe Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr 
                565                 570                 575     


Leu Leu Asn Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val 
            580                 585                 590         


Ile Leu Gln Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala 
        595                 600                 605             


His Lys Lys Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Asn Val Tyr 
    610                 615                 620                 


Gln Lys Met Val Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro 
625                 630                 635                 640 


Lys Val Phe Phe Ala Lys Ser Asn Leu Asp Tyr Tyr Asn Pro Ser Ala 
                645                 650                 655     


Glu Leu Leu Asp Lys Tyr Ala Lys Gly Thr His Lys Lys Gly Asp Asn 
            660                 665                 670         


Phe Asn Leu Lys Asp Cys His Ala Leu Ile Asp Phe Phe Lys Ala Gly 
        675                 680                 685             


Ile Asn Lys His Pro Glu Trp Gln His Phe Gly Phe Lys Phe Ser Pro 
    690                 695                 700                 


Thr Ser Ser Tyr Arg Asp Leu Ser Asp Phe Tyr Arg Glu Val Glu Pro 
705                 710                 715                 720 


Gln Gly Tyr Gln Val Lys Phe Val Asp Ile Asn Ala Asp Tyr Ile Asp 
                725                 730                 735     


Glu Leu Val Glu Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
            740                 745                 750         


Asp Phe Ser Pro Lys Ala His Gly Lys Pro Asn Leu His Thr Leu Tyr 
        755                 760                 765             


Phe Lys Ala Leu Phe Ser Glu Asp Asn Leu Ala Asp Pro Ile Tyr Lys 
    770                 775                 780                 


Leu Asn Gly Glu Ala Gln Ile Phe Tyr Arg Lys Ala Ser Leu Asp Met 
785                 790                 795                 800 


Asn Glu Thr Thr Ile His Arg Ala Gly Glu Val Leu Glu Asn Lys Asn 
                805                 810                 815     


Pro Asp Asn Pro Lys Lys Arg Gln Phe Val Tyr Asp Ile Ile Lys Asp 
            820                 825                 830         


Lys Arg Tyr Thr Gln Asp Lys Phe Met Leu His Val Pro Ile Thr Met 
        835                 840                 845             


Asn Phe Gly Val Gln Gly Met Thr Ile Lys Glu Phe Asn Lys Lys Val 
    850                 855                 860                 


Asn Gln Ser Ile Gln Gln Tyr Asp Glu Val Asn Val Ile Gly Ile Asp 
865                 870                 875                 880 


Arg Gly Glu Arg His Leu Leu Tyr Leu Thr Val Ile Asn Ser Lys Gly 
                885                 890                 895     


Glu Ile Leu Glu Gln Arg Ser Leu Asn Asp Ile Thr Thr Ala Ser Ala 
            900                 905                 910         


Asn Gly Thr Gln Val Thr Thr Pro Tyr His Lys Ile Leu Asp Lys Arg 
        915                 920                 925             


Glu Ile Glu Arg Leu Asn Ala Arg Val Gly Trp Gly Glu Ile Glu Thr 
    930                 935                 940                 


Ile Lys Glu Leu Lys Ser Gly Tyr Leu Ser His Val Val His Gln Ile 
945                 950                 955                 960 


Asn Gln Leu Met Leu Lys Tyr Asn Ala Ile Val Val Leu Glu Asp Leu 
                965                 970                 975     


Asn Phe Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln Ile Tyr 
            980                 985                 990         


Gln Asn Phe Glu Asn Ala Leu Ile  Lys Lys Leu Asn His  Leu Val Leu 
        995                 1000                 1005             


Lys Asp  Lys Ala Asp Asp Glu  Ile Gly Ser Tyr Lys  Asn Ala Leu 
    1010                 1015                 1020             


Gln Leu  Thr Asn Asn Phe Thr  Asp Leu Lys Ser Ile  Gly Lys Gln 
    1025                 1030                 1035             


Thr Gly  Phe Leu Phe Tyr Val  Pro Ala Trp Asn Thr  Ser Lys Ile 
    1040                 1045                 1050             


Asp Pro  Glu Thr Gly Phe Val  Asp Leu Leu Lys Pro  Arg Tyr Glu 
    1055                 1060                 1065             


Asn Ile  Ala Gln Ser Gln Ala  Phe Phe Gly Lys Phe  Asp Lys Ile 
    1070                 1075                 1080             


Cys Tyr  Asn Thr Asp Lys Gly  Tyr Phe Glu Phe His  Ile Asp Tyr 
    1085                 1090                 1095             


Ala Lys  Phe Thr Asp Lys Ala  Lys Asn Ser Arg Gln  Lys Trp Ala 
    1100                 1105                 1110             


Ile Cys  Ser His Gly Asp Lys  Arg Tyr Val Tyr Asp  Lys Thr Ala 
    1115                 1120                 1125             


Asn Gln  Asn Lys Gly Ala Ala  Lys Gly Ile Asn Val  Asn Asp Glu 
    1130                 1135                 1140             


Leu Lys  Ser Leu Phe Ala Arg  Tyr His Ile Asn Asp  Lys Gln Pro 
    1145                 1150                 1155             


Asn Leu  Val Met Asp Ile Cys  Gln Asn Asn Asp Lys  Glu Phe His 
    1160                 1165                 1170             


Lys Ser  Leu Met Cys Leu Leu  Lys Thr Leu Leu Ala  Leu Arg Tyr 
    1175                 1180                 1185             


Ser Asn  Ala Ser Ser Asp Glu  Asp Phe Ile Leu Ser  Pro Val Ala 
    1190                 1195                 1200             


Asn Asp  Glu Gly Val Phe Phe  Asn Ser Ala Leu Ala  Asp Asp Thr 
    1205                 1210                 1215             


Gln Pro  Gln Asn Ala Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu 
    1220                 1225                 1230             


Lys Gly  Leu Trp Leu Leu Asn  Glu Leu Lys Asn Ser  Asp Asp Leu 
    1235                 1240                 1245             


Asn Lys  Val Lys Leu Ala Ile  Asp Asn Gln Thr Trp  Leu Asn Phe 
    1250                 1255                 1260             


Ala Gln  Asn Arg Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1265                 1270                 1275             


Ala Lys  Lys Lys Lys 
    1280             


<210>  47
<211>  1352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn Lys 
    1295                 1300                 1305             


Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys 
    1310                 1315                 1320             


Gly Ser  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala Tyr  Pro Tyr Asp 
    1325                 1330                 1335             


Val Pro  Asp Tyr Ala Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala 
    1340                 1345                 1350         


<210>  48
<211>  1387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synethtic


<220>
<221>  xSV40NLS-06
<222>  (2)..(8)

<220>
<221>  xLinker-06
<222>  (9)..(39)

<220>
<221>  xSV40NLS-04
<222>  (1339)..(1345)

<220>
<221>  xsGGSlinker-02
<222>  (1346)..(1349)

<220>
<221>  xsGGSlinker-02
<222>  (1350)..(1353)

<220>
<221>  xSV40NLS-07
<222>  (1354)..(1360)

<220>
<221>  tag3XHA
<222>  (1361)..(1387)

<400>  48

Met Pro Lys Lys Lys Arg Lys Val Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Met Ser Ile Tyr Gln Glu Phe Val Asn Lys 
        35                  40                  45              


Tyr Ser Leu Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys 
    50                  55                  60                  


Thr Leu Glu Asn Ile Lys Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys 
65                  70                  75                  80  


Arg Ala Lys Asp Tyr Lys Lys Ala Lys Gln Ile Ile Asp Lys Tyr His 
                85                  90                  95      


Gln Phe Phe Ile Glu Glu Ile Leu Ser Ser Val Cys Ile Ser Glu Asp 
            100                 105                 110         


Leu Leu Gln Asn Tyr Ser Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp 
        115                 120                 125             


Asp Asp Asn Leu Gln Lys Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys 
    130                 135                 140                 


Lys Gln Ile Ser Glu Tyr Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu 
145                 150                 155                 160 


Phe Asn Gln Asn Leu Ile Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu 
                165                 170                 175     


Ile Leu Trp Leu Lys Gln Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys 
            180                 185                 190         


Ala Asn Ser Asp Ile Thr Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys 
        195                 200                 205             


Ser Phe Lys Gly Trp Thr Thr Tyr Phe Lys Gly Phe His Glu Asn Arg 
    210                 215                 220                 


Lys Asn Val Tyr Ser Ser Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg 
225                 230                 235                 240 


Ile Val Asp Asp Asn Leu Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr 
                245                 250                 255     


Glu Ser Leu Lys Asp Lys Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile 
            260                 265                 270         


Lys Lys Asp Leu Ala Glu Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr 
        275                 280                 285             


Ser Glu Val Asn Gln Arg Val Phe Ser Leu Asp Glu Val Phe Glu Ile 
    290                 295                 300                 


Ala Asn Phe Asn Asn Tyr Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn 
305                 310                 315                 320 


Thr Ile Ile Gly Gly Lys Phe Val Asn Gly Glu Asn Thr Lys Arg Lys 
                325                 330                 335     


Gly Ile Asn Glu Tyr Ile Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys 
            340                 345                 350         


Thr Leu Lys Lys Tyr Lys Met Ser Val Leu Phe Lys Gln Ile Leu Ser 
        355                 360                 365             


Asp Thr Glu Ser Lys Ser Phe Val Ile Asp Lys Leu Glu Asp Asp Ser 
    370                 375                 380                 


Asp Val Val Thr Thr Met Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe 
385                 390                 395                 400 


Lys Thr Val Glu Glu Lys Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe 
                405                 410                 415     


Asp Asp Leu Lys Ala Gln Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys 
            420                 425                 430         


Asn Asp Lys Ser Leu Thr Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr 
        435                 440                 445             


Ser Val Ile Gly Thr Ala Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala 
    450                 455                 460                 


Pro Lys Asn Leu Asp Asn Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala 
465                 470                 475                 480 


Lys Lys Thr Glu Lys Ala Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu 
                485                 490                 495     


Ala Leu Glu Glu Phe Asn Lys His Arg Asp Ile Asp Lys Gln Cys Arg 
            500                 505                 510         


Phe Glu Glu Ile Leu Ala Asn Phe Ala Ala Ile Pro Met Ile Phe Asp 
        515                 520                 525             


Glu Ile Ala Gln Asn Lys Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr 
    530                 535                 540                 


Gln Asn Gln Gly Lys Lys Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp 
545                 550                 555                 560 


Val Lys Ala Ile Lys Asp Leu Leu Asp Gln Thr Asn Asn Leu Leu His 
                565                 570                 575     


Lys Leu Lys Ile Phe His Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile 
            580                 585                 590         


Leu Asp Lys Asp Glu His Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe 
        595                 600                 605             


Glu Leu Ala Asn Ile Val Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile 
    610                 615                 620                 


Thr Gln Lys Pro Tyr Ser Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn 
625                 630                 635                 640 


Ser Thr Leu Ala Asn Gly Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr 
                645                 650                 655     


Ala Ile Leu Phe Ile Lys Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn 
            660                 665                 670         


Lys Lys Asn Asn Lys Ile Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys 
        675                 680                 685             


Gly Glu Gly Tyr Lys Lys Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn 
    690                 695                 700                 


Lys Met Leu Pro Lys Val Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr 
705                 710                 715                 720 


Asn Pro Ser Glu Asp Ile Leu Arg Ile Arg Asn His Ser Thr His Thr 
                725                 730                 735     


Lys Asn Gly Ser Pro Gln Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile 
            740                 745                 750         


Glu Asp Cys Arg Lys Phe Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys 
        755                 760                 765             


His Pro Glu Trp Lys Asp Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg 
    770                 775                 780                 


Tyr Asn Ser Ile Asp Glu Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr 
785                 790                 795                 800 


Lys Leu Thr Phe Glu Asn Ile Ser Glu Ser Tyr Ile Asp Ser Val Val 
                805                 810                 815     


Asn Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser 
            820                 825                 830         


Ala Tyr Ser Lys Gly Arg Pro Asn Leu His Thr Leu Tyr Trp Lys Ala 
        835                 840                 845             


Leu Phe Asp Glu Arg Asn Leu Gln Asp Val Val Tyr Lys Leu Asn Gly 
    850                 855                 860                 


Glu Ala Glu Leu Phe Tyr Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr 
865                 870                 875                 880 


His Pro Ala Lys Glu Ala Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys 
                885                 890                 895     


Lys Glu Ser Val Phe Glu Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr 
            900                 905                 910         


Glu Asp Lys Phe Phe Phe His Cys Pro Ile Thr Ile Asn Phe Lys Ser 
        915                 920                 925             


Ser Gly Ala Asn Lys Phe Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu 
    930                 935                 940                 


Lys Ala Asn Asp Val His Ile Leu Ser Ile Asp Arg Gly Glu Arg His 
945                 950                 955                 960 


Leu Ala Tyr Tyr Thr Leu Val Asp Gly Lys Gly Asn Ile Ile Lys Gln 
                965                 970                 975     


Asp Thr Phe Asn Ile Ile Gly Asn Asp Arg Met Lys Thr Asn Tyr His 
            980                 985                 990         


Asp Lys Leu Ala Ala Ile Glu Lys  Asp Arg Asp Ser Ala  Arg Lys Asp 
        995                 1000                 1005             


Trp Lys  Lys Ile Asn Asn Ile  Lys Glu Met Lys Glu  Gly Tyr Leu 
    1010                 1015                 1020             


Ser Gln  Val Val His Glu Ile  Ala Lys Leu Val Ile  Glu Tyr Asn 
    1025                 1030                 1035             


Ala Ile  Val Val Phe Glu Asp  Leu Asn Phe Gly Phe  Lys Arg Gly 
    1040                 1045                 1050             


Arg Phe  Lys Val Glu Lys Gln  Val Tyr Gln Lys Leu  Glu Lys Met 
    1055                 1060                 1065             


Leu Ile  Glu Lys Leu Asn Tyr  Leu Val Phe Lys Asp  Asn Glu Phe 
    1070                 1075                 1080             


Asp Lys  Thr Gly Gly Val Leu  Arg Ala Tyr Gln Leu  Thr Ala Pro 
    1085                 1090                 1095             


Phe Glu  Thr Phe Lys Lys Met  Gly Lys Gln Thr Gly  Ile Ile Tyr 
    1100                 1105                 1110             


Tyr Val  Pro Ala Gly Phe Thr  Ser Lys Ile Cys Pro  Val Thr Gly 
    1115                 1120                 1125             


Phe Val  Asn Gln Leu Tyr Pro  Lys Tyr Glu Ser Val  Ser Lys Ser 
    1130                 1135                 1140             


Gln Glu  Phe Phe Ser Lys Phe  Asp Lys Ile Cys Tyr  Asn Leu Asp 
    1145                 1150                 1155             


Lys Gly  Tyr Phe Glu Phe Ser  Phe Asp Tyr Lys Asn  Phe Gly Asp 
    1160                 1165                 1170             


Lys Ala  Ala Lys Gly Lys Trp  Thr Ile Ala Ser Phe  Gly Ser Arg 
    1175                 1180                 1185             


Leu Ile  Asn Phe Arg Asn Ser  Asp Lys Asn His Asn  Trp Asp Thr 
    1190                 1195                 1200             


Arg Glu  Val Tyr Pro Thr Lys  Glu Leu Glu Lys Leu  Leu Lys Asp 
    1205                 1210                 1215             


Tyr Ser  Ile Glu Tyr Gly His  Gly Glu Cys Ile Lys  Ala Ala Ile 
    1220                 1225                 1230             


Cys Gly  Glu Ser Asp Lys Lys  Phe Phe Ala Lys Leu  Thr Ser Val 
    1235                 1240                 1245             


Leu Asn  Thr Ile Leu Gln Met  Arg Asn Ser Lys Thr  Gly Thr Glu 
    1250                 1255                 1260             


Leu Asp  Tyr Leu Ile Ser Pro  Val Ala Asp Val Asn  Gly Asn Phe 
    1265                 1270                 1275             


Phe Asp  Ser Arg Gln Ala Pro  Lys Asn Met Pro Gln  Asp Ala Asp 
    1280                 1285                 1290             


Ala Asn  Gly Ala Tyr His Ile  Gly Leu Lys Gly Leu  Met Leu Leu 
    1295                 1300                 1305             


Gly Arg  Ile Lys Asn Asn Gln  Glu Gly Lys Lys Leu  Asn Leu Val 
    1310                 1315                 1320             


Ile Lys  Asn Glu Glu Tyr Phe  Glu Phe Val Gln Asn  Arg Asn Asn 
    1325                 1330                 1335             


Pro Lys  Lys Lys Arg Lys Val  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1340                 1345                 1350             


Pro Lys  Lys Lys Arg Lys Val  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1355                 1360                 1365             


Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Tyr Pro  Tyr Asp Val 
    1370                 1375                 1380             


Pro Asp  Tyr Ala 
    1385         


<210>  49
<211>  4899
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg gccccgtggc ggtggacccc       60

accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt tcttcgaccc cagggagctc      120

cgcaaggaga cctgcctcct gtacgagatc aactggggcg gcaggcactc catctggagg      180

cacacgagcc agaacaccaa caagcacgtc gaggtgaact tcatcgagaa gttcaccacg      240

gagaggtact tctgcccgaa cacgcgctgc tccatcacgt ggttcctctc gtggagccca      300

tgcggcgagt gctccagggc gatcacggag ttcctcagcc gctacccgca cgtgaccctg      360

ttcatctaca tcgctaggct ctaccaccac gcggacccca ggaacaggca gggcctcagg      420

gacctgatct ccagcggcgt cacgatccag atcatgaccg agcaggagtc cggctactgc      480

tggaggaact tcgtgaacta ctccccgagc aacgaggccc actggccccg ctacccgcac      540

ctctgggtcc gcctctacgt gctcgagctg tactgcatca tcctcggcct gccgccctgc      600

ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct tcaccatcgc cctgcagagc      660

tgccactacc agaggctccc gccccacatc ctgtgggcga ccgggctcaa ggggggcggg      720

ggctcaggcg ggggcgggag cggcggcggg ggctctgggg gcggcggcag cggcgggggc      780

ggcagcgggg gcggcgggtc gatgctcttc caggacttca cccacctcta cccgctgtcc      840

aagacggtga ggttcgagct gaagcccatc ggccgcaccc tcgagcacat ccacgccaag      900

aacttcctca gccaggacga gacgatggcg gacatgtacc agaaggtgaa ggtcatcctg      960

gacgactacc acagggactt catcgccgac atgatgggcg aggtgaagct caccaagctg     1020

gcggagttct acgacgtcta cctgaagttc cgcaagaacc cgaaggacga cggcctccag     1080

aagcagctca aggacctgca ggccgtgctg aggaaggagt cggtcaagcc aatcggcagc     1140

ggcggcaagt acaagaccgg ctacgacagg ctgttcggcg ccaagctctt caaggacggc     1200

aaggagctcg gcgacctggc caagttcgtg atcgcccagg agggcgagtc ctcgcccaag     1260

ctcgctcacc tggcccactt cgagaagttc tccacctact tcacgggctt ccacgacaac     1320

cgcaagaaca tgtacagcga cgaggacaag cacaccgcca tcgcgtacag gctgatccac     1380

gagaacctcc cccgcttcat cgacaacctc cagatcctga ccacgatcaa gcagaagcac     1440

tccgccctgt acgaccagat catcaacgag ctgacggctt cgggcctgga cgtgtccctg     1500

gccagccacc tcgacggcta ccacaagctc ctgacccagg agggcatcac ggcctacaac     1560

aggatcatcg gcgaggtcaa cggctacacg aacaagcaca accagatctg ccacaagtcg     1620

gagaggatcg ccaagctcag gcccctgcac aagcagatcc tgagcgacgg catgggcgtg     1680

tccttcctcc ccagcaagtt cgccgacgac tccgagatgt gccaggcggt caacgagttc     1740

taccgccact acaccgacgt gttcgccaag gtccagagcc tgttcgacgg cttcgacgac     1800

caccagaagg acggcatcta cgtggagcac aagaacctca acgagctgtc caagcaggcc     1860

ttcggcgact tcgccctcct gggcagggtg ctggacggct actacgtcga cgtggtcaac     1920

ccggagttca acgagcgctt cgccaaggcg aagaccgaca acgccaaggc gaagctgacg     1980

aaggagaagg acaagttcat caagggcgtc cactcgctgg ccagcctgga gcaggccatc     2040

gagcaccaca cggctaggca cgacgacgag tcggtgcagg ccggcaagct gggccagtac     2100

ttcaagcacg gcctggcggg cgtggacaac ccgatccaga agatccacaa caaccactcc     2160

accatcaagg gcttcctcga gagggagagg cccgcgggcg agagggcgct gcccaagatc     2220

aagagcggca agaaccccga gatgacgcag ctccgccagc tgaaggagct cctggacaac     2280

gccctcaacg tggcccactt cgcgaagctc ctgaccacga agaccacgct ggacaaccag     2340

gacggcaact tctacggcga gttcggcgtg ctgtacgacg agctcgcgaa gatcccgacc     2400

ctgtacaaca aggtccgcga ctacctctcc cagaagccgt tcagcaccga gaagtacaag     2460

ctcaacttcg gcaaccccac gctcctgaac ggctgggacc tgaacaagga gaaggacaac     2520

ttcggcgtga tcctgcagaa ggacggctgc tactacctcg ccctcctgga caaggcgcac     2580

aagaaggtct tcgacaacgc ccccaacacg ggcaagaacg tgtaccagaa gatggtctac     2640

aagctcctgc cgggccccaa caagatgctg ccgaaggtgt tcttcgcgaa gtccaacctc     2700

gactactaca accccagcgc cgagctcctg gacaagtacg cgaagggcac ccacaagaag     2760

ggcgacaact tcaacctgaa ggactgccac gccctcatcg acttcttcaa ggcgggcatc     2820

aacaagcacc cggagtggca gcacttcggc ttcaagttct cccccacgtc cagctacagg     2880

gacctcagcg acttctacag ggaggtggag ccccagggct accaggtgaa gttcgtcgac     2940

atcaacgccg actacatcga cgagctggtc gagcagggca agctctacct gttccagatc     3000

tacaacaagg acttctcgcc caaggcccac ggcaagccaa acctccacac cctgtacttc     3060

aaggccctgt tcagcgagga caacctcgcg gaccccatct acaagctcaa cggcgaggcc     3120

cagatcttct acaggaaggc gtccctggac atgaacgaga cgaccatcca cagggcgggc     3180

gaggtgctcg agaacaagaa cccggacaac cccaagaaga ggcagttcgt ctacgacatc     3240

atcaaggaca agcgctacac gcaggacaag ttcatgctgc acgtgccgat caccatgaac     3300

ttcggcgtcc agggcatgac gatcaaggag ttcaacaaga aggtgaacca gtccatccag     3360

cagtacgacg aggtgaacgt catcggcatc gctcgcggcg agaggcacct cctgtacctc     3420

accgtcatca acagcaaggg cgagatcctg gagcagaggt ccctcaacga catcacgacc     3480

gcttcggcca acggcacgca ggtgaccacg ccctaccaca agatcctgga caagcgcgag     3540

atcgagaggc tcaacgctag ggtgggctgg ggcgagatcg agaccatcaa ggagctgaag     3600

tccggctacc tcagccacgt ggtccaccag atcaaccagc tcatgctgaa gtacaacgcc     3660

atcgtggtcc tcgcggacct gaatttcggc ttcaagcgcg gcaggttcaa ggtggagaag     3720

cagatctacc agaacttcga gaacgccctg atcaagaagc tcaaccacct cgtcctgaag     3780

gacaaggccg acgacgagat cggctcctac aagaacgcgc tccagctgac caacaacttc     3840

acggacctga agagcatcgg caagcagacc ggcttcctct tctacgtgcc ggcgtggaac     3900

acctccaaga tcgaccccga gacgggcttc gtcgacctcc tgaagccgag gtacgagaac     3960

atcgcccaga gccaggcgtt cttcggcaag ttcgacaaga tctgctacaa caccgacaag     4020

ggctacttcg agttccacat cgactacgcc aagttcacgg acaaggcgaa gaactccagg     4080

cagaagtggg ccatctgcag ccacggcgac aagcgctacg tgtacgacaa gaccgcgaac     4140

cagaacaagg gcgccgcgaa gggcatcaac gtcaacgacg agctcaagtc cctgttcgcc     4200

cgctaccaca tcaacgacaa gcagccgaac ctcgtgatgg acatctgcca gaacaacgac     4260

aaggagttcc acaagagcct gatgtgcctc ctgaagaccc tcctggccct ccgctactcc     4320

aacgcctcca gcgacgaggc gttcatcctg agccccgtgg ccaacgacga gggcgtcttc     4380

ttcaactcgg ctctggccga cgacacccag ccacagaacg cggacgccaa cggcgcttac     4440

cacatcgcgc tcaagggcct gtggctcctg aacgagctca agaacagcga cgacctgaac     4500

aaggtcaagc tcgccatcga caaccagacc tggctgaact tcgcccagaa ccgcaagagg     4560

cccgcggcca cgaagaaggc gggccaggcc aagaagaaga agtccggcgg cagcacgaac     4620

ctgtccgaca tcatcgagaa ggagaccggc aagcagctcg tgatccagga gagcatcctc     4680

atgctgccgg aggaggtcga ggaggtcatc ggcaacaagc ccgagtccga catcctcgtc     4740

cacacggcct acgacgagtc caccgacgag aacgtgatgc tcctgacctc ggacgctccc     4800

gagtacaagc catgggccct ggtcatccag gacagcaacg gcgagaacaa gatcaagatg     4860

ctctccggcg gcagcccgaa gaagaagcgc aaagtgtga                            4899


<210>  50
<211>  1632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  50

Met Pro Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val 
1               5                   10                  15      


Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu 
            20                  25                  30          


Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr 
        35                  40                  45              


Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln 
    50                  55                  60                  


Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr 
65                  70                  75                  80  


Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu 
                85                  90                  95      


Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu 
            100                 105                 110         


Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr 
        115                 120                 125             


His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser 
    130                 135                 140                 


Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys 
145                 150                 155                 160 


Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro 
                165                 170                 175     


Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys 
            180                 185                 190         


Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln 
        195                 200                 205             


Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln 
    210                 215                 220                 


Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Phe Gln Asp 
            260                 265                 270         


Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val Arg Phe Glu Leu Lys 
        275                 280                 285             


Pro Ile Gly Arg Thr Leu Glu His Ile His Ala Lys Asn Phe Leu Ser 
    290                 295                 300                 


Gln Asp Glu Thr Met Ala Asp Met Tyr Gln Lys Val Lys Val Ile Leu 
305                 310                 315                 320 


Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met Met Gly Glu Val Lys 
                325                 330                 335     


Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr Leu Lys Phe Arg Lys 
            340                 345                 350         


Asn Pro Lys Asp Asp Gly Leu Gln Lys Gln Leu Lys Asp Leu Gln Ala 
        355                 360                 365             


Val Leu Arg Lys Glu Ser Val Lys Pro Ile Gly Ser Gly Gly Lys Tyr 
    370                 375                 380                 


Lys Thr Gly Tyr Asp Arg Leu Phe Gly Ala Lys Leu Phe Lys Asp Gly 
385                 390                 395                 400 


Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile Ala Gln Glu Gly Glu 
                405                 410                 415     


Ser Ser Pro Lys Leu Ala His Leu Ala His Phe Glu Lys Phe Ser Thr 
            420                 425                 430         


Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn Met Tyr Ser Asp Glu 
        435                 440                 445             


Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile His Glu Asn Leu Pro 
    450                 455                 460                 


Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr Ile Lys Gln Lys His 
465                 470                 475                 480 


Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu Thr Ala Ser Gly Leu 
                485                 490                 495     


Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr His Lys Leu Leu Thr 
            500                 505                 510         


Gln Glu Gly Ile Thr Ala Tyr Asn Arg Ile Ile Gly Glu Val Asn Gly 
        515                 520                 525             


Tyr Thr Asn Lys His Asn Gln Ile Cys His Lys Ser Glu Arg Ile Ala 
    530                 535                 540                 


Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser Asp Gly Met Gly Val 
545                 550                 555                 560 


Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser Glu Met Cys Gln Ala 
                565                 570                 575     


Val Asn Glu Phe Tyr Arg His Tyr Thr Asp Val Phe Ala Lys Val Gln 
            580                 585                 590         


Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys Asp Gly Ile Tyr Val 
        595                 600                 605             


Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln Ala Phe Gly Asp Phe 
    610                 615                 620                 


Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr Val Asp Val Val Asn 
625                 630                 635                 640 


Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys Thr Asp Asn Ala Lys 
                645                 650                 655     


Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile Lys Gly Val His Ser 
            660                 665                 670         


Leu Ala Ser Leu Glu Gln Ala Ile Glu His His Thr Ala Arg His Asp 
        675                 680                 685             


Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln Tyr Phe Lys His Gly 
    690                 695                 700                 


Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile His Asn Asn His Ser 
705                 710                 715                 720 


Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro Ala Gly Glu Arg Ala 
                725                 730                 735     


Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu Met Thr Gln Leu Arg 
            740                 745                 750         


Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn Val Ala His Phe Ala 
        755                 760                 765             


Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn Gln Asp Gly Asn Phe 
    770                 775                 780                 


Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu Ala Lys Ile Pro Thr 
785                 790                 795                 800 


Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln Lys Pro Phe Ser Thr 
                805                 810                 815     


Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr Leu Leu Asn Gly Trp 
            820                 825                 830         


Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val Ile Leu Gln Lys Asp 
        835                 840                 845             


Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala His Lys Lys Val Phe 
    850                 855                 860                 


Asp Asn Ala Pro Asn Thr Gly Lys Asn Val Tyr Gln Lys Met Val Tyr 
865                 870                 875                 880 


Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ala 
                885                 890                 895     


Lys Ser Asn Leu Asp Tyr Tyr Asn Pro Ser Ala Glu Leu Leu Asp Lys 
            900                 905                 910         


Tyr Ala Lys Gly Thr His Lys Lys Gly Asp Asn Phe Asn Leu Lys Asp 
        915                 920                 925             


Cys His Ala Leu Ile Asp Phe Phe Lys Ala Gly Ile Asn Lys His Pro 
    930                 935                 940                 


Glu Trp Gln His Phe Gly Phe Lys Phe Ser Pro Thr Ser Ser Tyr Arg 
945                 950                 955                 960 


Asp Leu Ser Asp Phe Tyr Arg Glu Val Glu Pro Gln Gly Tyr Gln Val 
                965                 970                 975     


Lys Phe Val Asp Ile Asn Ala Asp Tyr Ile Asp Glu Leu Val Glu Gln 
            980                 985                 990         


Gly Lys Leu Tyr Leu Phe Gln Ile  Tyr Asn Lys Asp Phe  Ser Pro Lys 
        995                 1000                 1005             


Ala His  Gly Lys Pro Asn Leu  His Thr Leu Tyr Phe  Lys Ala Leu 
    1010                 1015                 1020             


Phe Ser  Glu Asp Asn Leu Ala  Asp Pro Ile Tyr Lys  Leu Asn Gly 
    1025                 1030                 1035             


Glu Ala  Gln Ile Phe Tyr Arg  Lys Ala Ser Leu Asp  Met Asn Glu 
    1040                 1045                 1050             


Thr Thr  Ile His Arg Ala Gly  Glu Val Leu Glu Asn  Lys Asn Pro 
    1055                 1060                 1065             


Asp Asn  Pro Lys Lys Arg Gln  Phe Val Tyr Asp Ile  Ile Lys Asp 
    1070                 1075                 1080             


Lys Arg  Tyr Thr Gln Asp Lys  Phe Met Leu His Val  Pro Ile Thr 
    1085                 1090                 1095             


Met Asn  Phe Gly Val Gln Gly  Met Thr Ile Lys Glu  Phe Asn Lys 
    1100                 1105                 1110             


Lys Val  Asn Gln Ser Ile Gln  Gln Tyr Asp Glu Val  Asn Val Ile 
    1115                 1120                 1125             


Gly Ile  Ala Arg Gly Glu Arg  His Leu Leu Tyr Leu  Thr Val Ile 
    1130                 1135                 1140             


Asn Ser  Lys Gly Glu Ile Leu  Glu Gln Arg Ser Leu  Asn Asp Ile 
    1145                 1150                 1155             


Thr Thr  Ala Ser Ala Asn Gly  Thr Gln Val Thr Thr  Pro Tyr His 
    1160                 1165                 1170             


Lys Ile  Leu Asp Lys Arg Glu  Ile Glu Arg Leu Asn  Ala Arg Val 
    1175                 1180                 1185             


Gly Trp  Gly Glu Ile Glu Thr  Ile Lys Glu Leu Lys  Ser Gly Tyr 
    1190                 1195                 1200             


Leu Ser  His Val Val His Gln  Ile Asn Gln Leu Met  Leu Lys Tyr 
    1205                 1210                 1215             


Asn Ala  Ile Val Val Leu Ala  Asp Leu Asn Phe Gly  Phe Lys Arg 
    1220                 1225                 1230             


Gly Arg  Phe Lys Val Glu Lys  Gln Ile Tyr Gln Asn  Phe Glu Asn 
    1235                 1240                 1245             


Ala Leu  Ile Lys Lys Leu Asn  His Leu Val Leu Lys  Asp Lys Ala 
    1250                 1255                 1260             


Asp Asp  Glu Ile Gly Ser Tyr  Lys Asn Ala Leu Gln  Leu Thr Asn 
    1265                 1270                 1275             


Asn Phe  Thr Asp Leu Lys Ser  Ile Gly Lys Gln Thr  Gly Phe Leu 
    1280                 1285                 1290             


Phe Tyr  Val Pro Ala Trp Asn  Thr Ser Lys Ile Asp  Pro Glu Thr 
    1295                 1300                 1305             


Gly Phe  Val Asp Leu Leu Lys  Pro Arg Tyr Glu Asn  Ile Ala Gln 
    1310                 1315                 1320             


Ser Gln  Ala Phe Phe Gly Lys  Phe Asp Lys Ile Cys  Tyr Asn Thr 
    1325                 1330                 1335             


Asp Lys  Gly Tyr Phe Glu Phe  His Ile Asp Tyr Ala  Lys Phe Thr 
    1340                 1345                 1350             


Asp Lys  Ala Lys Asn Ser Arg  Gln Lys Trp Ala Ile  Cys Ser His 
    1355                 1360                 1365             


Gly Asp  Lys Arg Tyr Val Tyr  Asp Lys Thr Ala Asn  Gln Asn Lys 
    1370                 1375                 1380             


Gly Ala  Ala Lys Gly Ile Asn  Val Asn Asp Glu Leu  Lys Ser Leu 
    1385                 1390                 1395             


Phe Ala  Arg Tyr His Ile Asn  Asp Lys Gln Pro Asn  Leu Val Met 
    1400                 1405                 1410             


Asp Ile  Cys Gln Asn Asn Asp  Lys Glu Phe His Lys  Ser Leu Met 
    1415                 1420                 1425             


Cys Leu  Leu Lys Thr Leu Leu  Ala Leu Arg Tyr Ser  Asn Ala Ser 
    1430                 1435                 1440             


Ser Asp  Glu Ala Phe Ile Leu  Ser Pro Val Ala Asn  Asp Glu Gly 
    1445                 1450                 1455             


Val Phe  Phe Asn Ser Ala Leu  Ala Asp Asp Thr Gln  Pro Gln Asn 
    1460                 1465                 1470             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Trp 
    1475                 1480                 1485             


Leu Leu  Asn Glu Leu Lys Asn  Ser Asp Asp Leu Asn  Lys Val Lys 
    1490                 1495                 1500             


Leu Ala  Ile Asp Asn Gln Thr  Trp Leu Asn Phe Ala  Gln Asn Arg 
    1505                 1510                 1515             


Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys 
    1520                 1525                 1530             


Lys Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1535                 1540                 1545             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1550                 1555                 1560             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1565                 1570                 1575             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1580                 1585                 1590             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1595                 1600                 1605             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1610                 1615                 1620             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1625                 1630         


<210>  51
<211>  4809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
atgccgaaga agaagcgcaa ggtcatgtcc agcgagaccg gccccgtggc ggtggacccc       60

accctgcgca ggcgcatcga gccgcacgag ttcgaggtgt tcttcgaccc cagggagctc      120

cgcaaggaga cctgcctcct gtacgagatc aactggggcg gcaggcactc catctggagg      180

cacacgagcc agaacaccaa caagcacgtc gaggtgaact tcatcgagaa gttcaccacg      240

gagaggtact tctgcccgaa cacgcgctgc tccatcacgt ggttcctctc gtggagccca      300

tgcggcgagt gctccagggc gatcacggag ttcctcagcc gctacccgca cgtgaccctg      360

ttcatctaca tcgctaggct ctaccaccac gcggacccca ggaacaggca gggcctcagg      420

gacctgatct ccagcggcgt cacgatccag atcatgaccg agcaggagtc cggctactgc      480

tggaggaact tcgtgaacta ctccccgagc aacgaggccc actggccccg ctacccgcac      540

ctctgggtcc gcctctacgt gctcgagctg tactgcatca tcctcggcct gccgccctgc      600

ctcaacatcc tgaggcgcaa gcagccccag ctgacgttct tcaccatcgc cctgcagagc      660

tgccactacc agaggctccc gccccacatc ctgtgggcga ccgggctcaa ggggggcggg      720

ggctcaggcg ggggcgggag cggcggcggg ggctctgggg gcggcggcag cggcgggggc      780

ggcagcgggg gcggcgggtc gatgagcaag ctggagaagt tcacgaactg ctactccctc      840

agcaagaccc tgaggttcaa ggcgatcccg gtcggcaaga cccaggagaa catcgacaac      900

aagcggctgc tggtggagga cgagaagagg gctgaggact acaagggcgt gaagaagctc      960

ctggaccgct actacctgtc cttcatcaac gacgtgctcc acagcatcaa gctcaagaac     1020

ctgaacaact acatcagcct cttcaggaag aagacgcgca ccgagaagga gaacaaggag     1080

ctcgagaacc tggagatcaa cctgaggaag gagatcgcca aggcgttcaa gggcaacgag     1140

ggctacaagt ccctcttcaa gaaggacatc atcgagacga tcctcccgga gttcctggac     1200

gacaaggacg agatcgccct ggtcaactcc ttcaacggct tcaccacggc gttcaccggc     1260

ttcttcgaca accgcgagaa catgttcagc gaggaggcca agtccacgag catcgcgttc     1320

aggtgcatca acgagaacct cacccgctac atctccaaca tggacatctt cgagaaggtc     1380

gacgcgatct tcgacaagca cgaggtgcag gagatcaagg agaagatcct gaacagcgac     1440

tacgacgtcg aggacttctt cgagggcgag ttcttcaact tcgtcctcac gcaggagggc     1500

atcgacgtgt acaacgccat catcggtggc ttcgtgaccg agtccggcga gaagatcaag     1560

ggcctgaacg agtacatcaa cctctacaac cagaagacca agcagaagct gccgaagttc     1620

aagcccctgt acaagcaggt gctctccgac agggagtccc tcagcttcta cggcgagggc     1680

tacacgagcg acgaggaggt cctggaggtg ttccgcaaca ccctcaacaa gaacagcgag     1740

atcttctcca gcatcaagaa gctcgagaag ctgttcaaga acttcgacga gtactccagc     1800

gccggcatct tcgtcaagaa cggcccggcg atctccacga tcagcaagga catcttcggc     1860

gagtggaacg tgatccgcga caagtggaac gccgagtacg acgacatcca cctcaagaag     1920

aaggcggtgg tcaccgagaa gtacgaggac gacaggcgca agtccttcaa gaagatcggc     1980

tccttcagcc tcgagcagct gcaggagtac gccgacgcgg acctgagcgt ggtcgagaag     2040

ctcaaggaga tcatcatcca gaaggtcgac gagatctaca aggtgtacgg ctccagcgag     2100

aagctcttcg acgcggactt cgtcctcgag aagtccctga agaagaacga cgccgtggtc     2160

gcgatcatga aggacctcct ggactccgtg aagagcttcg agaattacat caaggccttc     2220

ttcggcgagg gcaaggagac gaacagggac gagtccttct acggcgactt cgtcctggcc     2280

tacgacatcc tcctgaaggt ggaccacatc tacgacgcga tccgcaacta cgtgacccag     2340

aagccgtaca gcaaggacaa gttcaagctc tacttccaga acccccagtt catgggcggc     2400

tgggacaagg acaaggagac ggactacagg gcgaccatcc tgcgctacgg cagcaagtac     2460

tacctcgcca tcatggacaa gaagtacgcg aagtgcctgc agaagatcga caaggacgac     2520

gtcaacggca actacgagaa gatcaactac aagctcctgc cgggccccaa caagatgctc     2580

ccgaaggtgt tcttctccaa gaagtggatg gcctactaca accccagcga ggacatccag     2640

aagatctaca agaacggcac gttcaagaag ggcgacatgt tcaacctgaa cgactgccac     2700

aagctcatcg acttcttcaa ggactccatc agccgctacc cgaagtggtc caacgcctac     2760

gacttcaact tcagcgagac cgagaagtac aaggacatcg cgggcttcta ccgcgaggtc     2820

gaggagcagg gctacaaggt gtccttcgag tccgccagca agaaggaggt cgacaagctg     2880

gtggaggagg gcaagctcta catgttccag atctacaaca aggacttctc cgacaagagc     2940

cacggcacgc ccaacctgca caccatgtac ttcaagctcc tgttcgacga gaacaaccac     3000

ggccagatca ggctgtccgg cggcgccgag ctcttcatga ggagggcgag cctgaagaag     3060

gaggagctgg tggtccaccc cgctaacagc ccaatcgcga acaagaaccc ggacaacccc     3120

aagaagacca cgaccctgtc ctacgacgtg tacaaggaca agaggttcag cgaggaccag     3180

tacgagctcc acatcccgat cgcgatcaac aagtgcccca agaacatctt caagatcaac     3240

accgaggtcc gcgtgctcct gaagcacgac gacaacccct acgtgatcgg catcgacagg     3300

ggcgagagga acctcctgta catcgtggtc gtggacggca agggcaacat cgtggagcag     3360

tactccctca acgagatcat caacaacttc aacggcatca ggatcaagac ggactaccac     3420

agcctcctgg acaagaagga gaaggagagg ttcgaggccc gccagaactg gacctccatc     3480

gagaacatca aggagctgaa ggcgggctac atcagccagg tcgtgcacaa gatctgcgag     3540

ctcgtcgaga agtacgacgc cgtgatcgcc ctcgaggacc tgaactccgg cttcaagaac     3600

agccgcgtca aggtggagaa gcaggtctac cagaagttcg agaagatgct catcgacaag     3660

ctgaactaca tggtggacaa gaagtccaac ccctgcgcta cgggcggcgc gctgaagggc     3720

taccagatca ccaacaagtt cgagagcttc aagtccatga gcactcagaa cggcttcatc     3780

ttctacatcc cggcgtggct cacgtccaag atcgacccca gcaccggctt cgtcaacctc     3840

ctgaagacga agtacacctc catcgccgac agcaagaagt tcatctccag cttcgaccgc     3900

atcatgtatg tgccggagga ggacctgttc gagttcgccc tcgactacaa gaacttctcc     3960

cgcacggacg cggactacat caagaagtgg aagctgtaca gctacggcaa ccgcatccgc     4020

atcttcagga accccaagaa gaacaacgtc ttcgactggg aggaggtgtg cctgacctcc     4080

gcgtacaagg agctcttcaa caagtacggc atcaactacc agcagggcga catcagggct     4140

ctcctgtgcg agcagagcga caaggccttc tactccagct tcatggcgct gatgtccctc     4200

atgctgcaga tgaggaactc gatcaccggc aggacggacg tggacttcct catctccccg     4260

gtgaagaaca gcgacggcat cttctacgac tccaggaact acgaggccca ggagaacgcg     4320

atcctcccaa agaacgcgga cgccaacggc gcctacaaca tcgccaggaa ggtcctctgg     4380

gctatcggcc agttcaagaa ggcggaggac gagaagctgg acaaggtgaa gatcgccatc     4440

agcaacaagg agtggctcga gtacgcccag acctcggtca agcacggcag cccgaagaag     4500

aagcgcaagg tgtccggcgg cagcacgaac ctgtccgaca tcatcgagaa ggagaccggc     4560

aagcagctcg tgatccagga gagcatcctc atgctgccgg aggaggtcga ggaggtcatc     4620

ggcaacaagc ccgagtccga catcctcgtc cacacggcct acgacgagtc caccgacgag     4680

aacgtgatgc tcctgacctc ggacgctccc gagtacaagc catgggccct ggtcatccag     4740

gacagcaacg gcgagaacaa gatcaagatg ctctccggcg gcagcccgaa gaagaagcgc     4800

aaagtgtga                                                             4809


<210>  52
<211>  1602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  52

Met Pro Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val 
1               5                   10                  15      


Ala Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu 
            20                  25                  30          


Val Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr 
        35                  40                  45              


Glu Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln 
    50                  55                  60                  


Asn Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr 
65                  70                  75                  80  


Glu Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu 
                85                  90                  95      


Ser Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu 
            100                 105                 110         


Ser Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr 
        115                 120                 125             


His His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser 
    130                 135                 140                 


Ser Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys 
145                 150                 155                 160 


Trp Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro 
                165                 170                 175     


Arg Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys 
            180                 185                 190         


Ile Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln 
        195                 200                 205             


Pro Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln 
    210                 215                 220                 


Arg Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Lys Leu Glu 
            260                 265                 270         


Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala 
        275                 280                 285             


Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu 
    290                 295                 300                 


Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu 
305                 310                 315                 320 


Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile 
                325                 330                 335     


Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr 
            340                 345                 350         


Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu 
        355                 360                 365             


Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser 
    370                 375                 380                 


Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp 
385                 390                 395                 400 


Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr 
                405                 410                 415     


Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu 
            420                 425                 430         


Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr 
        435                 440                 445             


Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe 
    450                 455                 460                 


Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp 
465                 470                 475                 480 


Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu 
                485                 490                 495     


Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val 
            500                 505                 510         


Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu 
        515                 520                 525             


Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr 
    530                 535                 540                 


Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly 
545                 550                 555                 560 


Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn 
                565                 570                 575     


Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe 
            580                 585                 590         


Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly 
        595                 600                 605             


Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val 
    610                 615                 620                 


Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys 
625                 630                 635                 640 


Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe 
                645                 650                 655     


Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp 
            660                 665                 670         


Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys 
        675                 680                 685             


Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp 
    690                 695                 700                 


Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val 
705                 710                 715                 720 


Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr 
                725                 730                 735     


Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser 
            740                 745                 750         


Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp 
        755                 760                 765             


His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser 
    770                 775                 780                 


Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly 
785                 790                 795                 800 


Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr 
                805                 810                 815     


Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys 
            820                 825                 830         


Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile 
        835                 840                 845             


Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe 
    850                 855                 860                 


Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln 
865                 870                 875                 880 


Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu 
                885                 890                 895     


Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg 
            900                 905                 910         


Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu 
        915                 920                 925             


Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly 
    930                 935                 940                 


Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu 
945                 950                 955                 960 


Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe 
                965                 970                 975     


Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys 
            980                 985                 990         


Leu Leu Phe Asp Glu Asn Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly 
        995                 1000                 1005             


Ala Glu  Leu Phe Met Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu 
    1010                 1015                 1020             


Val Val  His Pro Ala Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp 
    1025                 1030                 1035             


Asn Pro  Lys Lys Thr Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp 
    1040                 1045                 1050             


Lys Arg  Phe Ser Glu Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala 
    1055                 1060                 1065             


Ile Asn  Lys Cys Pro Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val 
    1070                 1075                 1080             


Arg Val  Leu Leu Lys His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile 
    1085                 1090                 1095             


Asp Arg  Gly Glu Arg Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly 
    1100                 1105                 1110             


Lys Gly  Asn Ile Val Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn 
    1115                 1120                 1125             


Asn Phe  Asn Gly Ile Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu 
    1130                 1135                 1140             


Asp Lys  Lys Glu Lys Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr 
    1145                 1150                 1155             


Ser Ile  Glu Asn Ile Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln 
    1160                 1165                 1170             


Val Val  His Lys Ile Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val 
    1175                 1180                 1185             


Ile Ala  Leu Glu Asp Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val 
    1190                 1195                 1200             


Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile 
    1205                 1210                 1215             


Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala 
    1220                 1225                 1230             


Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu 
    1235                 1240                 1245             


Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile 
    1250                 1255                 1260             


Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val 
    1265                 1270                 1275             


Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys 
    1280                 1285                 1290             


Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp 
    1295                 1300                 1305             


Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp 
    1310                 1315                 1320             


Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg 
    1325                 1330                 1335             


Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp 
    1340                 1345                 1350             


Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys 
    1355                 1360                 1365             


Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys 
    1370                 1375                 1380             


Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met 
    1385                 1390                 1395             


Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile Thr Gly  Arg Thr Asp 
    1400                 1405                 1410             


Val Asp  Phe Leu Ile Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe 
    1415                 1420                 1425             


Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro 
    1430                 1435                 1440             


Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val 
    1445                 1450                 1455             


Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu 
    1460                 1465                 1470             


Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr 
    1475                 1480                 1485             


Ala Gln  Thr Ser Val Lys His  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1490                 1495                 1500             


Val Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1505                 1510                 1515             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1520                 1525                 1530             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1535                 1540                 1545             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1550                 1555                 1560             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1565                 1570                 1575             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1580                 1585                 1590             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1595                 1600         


<210>  53
<211>  3873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
atgccgaaga agaagcgcaa ggtcgggggc gggggctcag gcgggggcgg gagcggcggc       60

gggggctctg ggggcggcgg cagcggcggg ggcggcagcg ggggcggcgg gtcgatgagc      120

aagctggaga agttcacgaa ctgctactcc ctcagcaaga ccctgaggtt caaggcgatc      180

ccggtcggca agacccagga gaacatcgac aacaagcggc tgctggtgga ggacgagaag      240

agggctgagg actacaaggg cgtgaagaag ctcctggacc gctactacct gtccttcatc      300

aacgacgtgc tccacagcat caagctcaag aacctgaaca actacatcag cctcttcagg      360

aagaagacgc gcaccgagaa ggagaacaag gagctcgaga acctggagat caacctgagg      420

aaggagatcg ccaaggcgtt caagggcaac gagggctaca agtccctctt caagaaggac      480

atcatcgaga cgatcctccc ggagttcctg gacgacaagg acgagatcgc cctggtcaac      540

tccttcaacg gcttcaccac ggcgttcacc ggcttcttcg acaaccgcga gaacatgttc      600

agcgaggagg ccaagtccac gagcatcgcg ttcaggtgca tcaacgagaa cctcacccgc      660

tacatctcca acatggacat cttcgagaag gtcgacgcga tcttcgacaa gcacgaggtg      720

caggagatca aggagaagat cctgaacagc gactacgacg tcgaggactt cttcgagggc      780

gagttcttca acttcgtcct cacgcaggag ggcatcgacg tgtacaacgc catcatcggt      840

ggcttcgtga ccgagtccgg cgagaagatc aagggcctga acgagtacat caacctctac      900

aaccagaaga ccaagcagaa gctgccgaag ttcaagcccc tgtacaagca ggtgctctcc      960

gacagggagt ccctcagctt ctacggcgag ggctacacga gcgacgagga ggtcctggag     1020

gtgttccgca acaccctcaa caagaacagc gagatcttct ccagcatcaa gaagctcgag     1080

aagctgttca agaacttcga cgagtactcc agcgccggca tcttcgtcaa gaacggcccg     1140

gcgatctcca cgatcagcaa ggacatcttc ggcgagtgga acgtgatccg cgacaagtgg     1200

aacgccgagt acgacgacat ccacctcaag aagaaggcgg tggtcaccga gaagtacgag     1260

gacgacaggc gcaagtcctt caagaagatc ggctccttca gcctcgagca gctgcaggag     1320

tacgccgacg cggacctgag cgtggtcgag aagctcaagg agatcatcat ccagaaggtc     1380

gacgagatct acaaggtgta cggctccagc gagaagctct tcgacgcgga cttcgtcctc     1440

gagaagtccc tgaagaagaa cgacgccgtg gtcgcgatca tgaaggacct cctggactcc     1500

gtgaagagct tcgagaatta catcaaggcc ttcttcggcg agggcaagga gacgaacagg     1560

gacgagtcct tctacggcga cttcgtcctg gcctacgaca tcctcctgaa ggtggaccac     1620

atctacgacg cgatccgcaa ctacgtgacc cagaagccgt acagcaagga caagttcaag     1680

ctctacttcc agaaccccca gttcatgggc ggctgggaca aggacaagga gacggactac     1740

agggcgacca tcctgcgcta cggcagcaag tactacctcg ccatcatgga caagaagtac     1800

gcgaagtgcc tgcagaagat cgacaaggac gacgtcaacg gcaactacga gaagatcaac     1860

tacaagctcc tgccgggccc caacaagatg ctcccgaagg tgttcttctc caagaagtgg     1920

atggcctact acaaccccag cgaggacatc cagaagatct acaagaacgg cacgttcaag     1980

aagggcgaca tgttcaacct gaacgactgc cacaagctca tcgacttctt caaggactcc     2040

atcagccgct acccgaagtg gtccaacgcc tacgacttca acttcagcga gaccgagaag     2100

tacaaggaca tcgcgggctt ctaccgcgag gtcgaggagc agggctacaa ggtgtccttc     2160

gagtccgcca gcaagaagga ggtcgacaag ctggtggagg agggcaagct ctacatgttc     2220

cagatctaca acaaggactt ctccgacaag agccacggca cgcccaacct gcacaccatg     2280

tacttcaagc tcctgttcga cgagaacaac cacggccaga tcaggctgtc cggcggcgcc     2340

gagctcttca tgaggagggc gagcctgaag aaggaggagc tggtggtcca ccccgctaac     2400

agcccaatcg cgaacaagaa cccggacaac cccaagaaga ccacgaccct gtcctacgac     2460

gtgtacaagg acaagaggtt cagcgaggac cagtacgagc tccacatccc gatcgcgatc     2520

aacaagtgcc ccaagaacat cttcaagatc aacaccgagg tccgcgtgct cctgaagcac     2580

gacgacaacc cctacgtgat cggcatcgac aggggcgaga ggaacctcct gtacatcgtg     2640

gtcgtggacg gcaagggcaa catcgtggag cagtactccc tcaacgagat catcaacaac     2700

ttcaacggca tcaggatcaa gacggactac cacagcctcc tggacaagaa ggagaaggag     2760

aggttcgagg cccgccagaa ctggacctcc atcgagaaca tcaaggagct gaaggcgggc     2820

tacatcagcc aggtcgtgca caagatctgc gagctcgtcg agaagtacga cgccgtgatc     2880

gccctcgagg acctgaactc cggcttcaag aacagccgcg tcaaggtgga gaagcaggtc     2940

taccagaagt tcgagaagat gctcatcgac aagctgaact acatggtgga caagaagtcc     3000

aacccctgcg ctacgggcgg cgcgctgaag ggctaccaga tcaccaacaa gttcgagagc     3060

ttcaagtcca tgagcactca gaacggcttc atcttctaca tcccggcgtg gctcacgtcc     3120

aagatcgacc ccagcaccgg cttcgtcaac ctcctgaaga cgaagtacac ctccatcgcc     3180

gacagcaaga agttcatctc cagcttcgac cgcatcatgt atgtgccgga ggaggacctg     3240

ttcgagttcg ccctcgacta caagaacttc tcccgcacgg acgcggacta catcaagaag     3300

tggaagctgt acagctacgg caaccgcatc cgcatcttca ggaaccccaa gaagaacaac     3360

gtcttcgact gggaggaggt gtgcctgacc tccgcgtaca aggagctctt caacaagtac     3420

ggcatcaact accagcaggg cgacatcagg gctctcctgt gcgagcagag cgacaaggcc     3480

ttctactcca gcttcatggc gctgatgtcc ctcatgctgc agatgaggaa ctcgatcacc     3540

ggcaggacgg acgtggactt cctcatctcc ccggtgaaga acagcgacgg catcttctac     3600

gactccagga actacgaggc ccaggagaac gcgatcctcc caaagaacgc ggacgccaac     3660

ggcgcctaca acatcgccag gaaggtcctc tgggctatcg gccagttcaa gaaggcggag     3720

gacgagaagc tggacaaggt gaagatcgcc atcagcaaca aggagtggct cgagtacgcc     3780

cagacctcgg tcaagcacgg cagcccgaag aagaagcgca aggtgtccgg cggcagctcc     3840

ggcggcagcc cgaagaagaa gcgcaaagtg tga                                  3873


<210>  54
<211>  1290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  54

Met Pro Lys Lys Lys Arg Lys Val Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn Cys 
        35                  40                  45              


Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys 
    50                  55                  60                  


Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys 
65                  70                  75                  80  


Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr 
                85                  90                  95      


Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu 
            100                 105                 110         


Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu 
        115                 120                 125             


Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala 
    130                 135                 140                 


Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp 
145                 150                 155                 160 


Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile 
                165                 170                 175     


Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe 
            180                 185                 190         


Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser 
        195                 200                 205             


Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn 
    210                 215                 220                 


Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val 
225                 230                 235                 240 


Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp 
                245                 250                 255     


Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile 
            260                 265                 270         


Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu 
        275                 280                 285             


Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr 
    290                 295                 300                 


Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser 
305                 310                 315                 320 


Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu 
                325                 330                 335     


Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile 
            340                 345                 350         


Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu 
        355                 360                 365             


Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr 
    370                 375                 380                 


Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp 
385                 390                 395                 400 


Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr 
                405                 410                 415     


Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser 
            420                 425                 430         


Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val 
        435                 440                 445             


Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr 
    450                 455                 460                 


Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu 
465                 470                 475                 480 


Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp 
                485                 490                 495     


Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe 
            500                 505                 510         


Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe 
        515                 520                 525             


Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala 
    530                 535                 540                 


Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys 
545                 550                 555                 560 


Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys 
                565                 570                 575     


Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr 
            580                 585                 590         


Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp 
        595                 600                 605             


Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu 
    610                 615                 620                 


Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp 
625                 630                 635                 640 


Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn 
                645                 650                 655     


Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys 
            660                 665                 670         


Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser 
        675                 680                 685             


Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile 
    690                 695                 700                 


Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe 
705                 710                 715                 720 


Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys 
                725                 730                 735     


Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His 
            740                 745                 750         


Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu 
        755                 760                 765             


Asn Asn His Gly Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met 
    770                 775                 780                 


Arg Arg Ala Ser Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn 
785                 790                 795                 800 


Ser Pro Ile Ala Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr 
                805                 810                 815     


Leu Ser Tyr Asp Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr 
            820                 825                 830         


Glu Leu His Ile Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe 
        835                 840                 845             


Lys Ile Asn Thr Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro 
    850                 855                 860                 


Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val 
865                 870                 875                 880 


Val Val Asp Gly Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu 
                885                 890                 895     


Ile Ile Asn Asn Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser 
            900                 905                 910         


Leu Leu Asp Lys Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp 
        915                 920                 925             


Thr Ser Ile Glu Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln 
    930                 935                 940                 


Val Val His Lys Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile 
945                 950                 955                 960 


Ala Leu Glu Asp Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val 
                965                 970                 975     


Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu 
            980                 985                 990         


Asn Tyr Met Val Asp Lys Lys Ser  Asn Pro Cys Ala Thr  Gly Gly Ala 
        995                 1000                 1005             


Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe Glu Ser  Phe Lys Ser 
    1010                 1015                 1020             


Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu 
    1025                 1030                 1035             


Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys 
    1040                 1045                 1050             


Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser 
    1055                 1060                 1065             


Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe 
    1070                 1075                 1080             


Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile 
    1085                 1090                 1095             


Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe 
    1100                 1105                 1110             


Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys 
    1115                 1120                 1125             


Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn 
    1130                 1135                 1140             


Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp 
    1145                 1150                 1155             


Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu Met Ser  Leu Met Leu 
    1160                 1165                 1170             


Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu 
    1175                 1180                 1185             


Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg 
    1190                 1195                 1200             


Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp 
    1205                 1210                 1215             


Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile 
    1220                 1225                 1230             


Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys 
    1235                 1240                 1245             


Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser 
    1250                 1255                 1260             


Val Lys  His Gly Ser Pro Lys  Lys Lys Arg Lys Val  Ser Gly Gly 
    1265                 1270                 1275             


Ser Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1280                 1285                 1290 


<210>  55
<211>  3873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
atgccgaaga agaagcgcaa ggtcgggggc gggggctcag gcgggggcgg gagcggcggc       60

gggggctctg ggggcggcgg cagcggcggg ggcggcagcg ggggcggcgg gtcgatgagc      120

aagctggaga agttcacgaa ctgctactcc ctcagcaaga ccctgaggtt caaggcgatc      180

ccggtcggca agacccagga gaacatcgac aacaagcggc tgctggtgga ggacgagaag      240

agggctgagg actacaaggg cgtgaagaag ctcctggacc gctactacct gtccttcatc      300

aacgacgtgc tccacagcat caagctcaag aacctgaaca actacatcag cctcttcagg      360

aagaagacgc gcaccgagaa ggagaacaag gagctcgaga acctggagat caacctgagg      420

aaggagatcg ccaaggcgtt caagggcaac gagggctaca agtccctctt caagaaggac      480

atcatcgaga cgatcctccc ggagttcctg gacgacaagg acgagatcgc cctggtcaac      540

tccttcaacg gcttcaccac ggcgttcacc ggcttcttcg acaaccgcga gaacatgttc      600

agcgaggagg ccaagtccac gagcatcgcg ttcaggtgca tcaacgagaa cctcacccgc      660

tacatctcca acatggacat cttcgagaag gtcgacgcga tcttcgacaa gcacgaggtg      720

caggagatca aggagaagat cctgaacagc gactacgacg tcgaggactt cttcgagggc      780

gagttcttca acttcgtcct cacgcaggag ggcatcgacg tgtacaacgc catcatcggt      840

ggcttcgtga ccgagtccgg cgagaagatc aagggcctga acgagtacat caacctctac      900

aaccagaaga ccaagcagaa gctgccgaag ttcaagcccc tgtacaagca ggtgctctcc      960

gacagggagt ccctcagctt ctacggcgag ggctacacga gcgacgagga ggtcctggag     1020

gtgttccgca acaccctcaa caagaacagc gagatcttct ccagcatcaa gaagctcgag     1080

aagctgttca agaacttcga cgagtactcc agcgccggca tcttcgtcaa gaacggcccg     1140

gcgatctcca cgatcagcaa ggacatcttc ggcgagtgga acgtgatccg cgacaagtgg     1200

aacgccgagt acgacgacat ccacctcaag aagaaggcgg tggtcaccga gaagtacgag     1260

gacgacaggc gcaagtcctt caagaagatc ggctccttca gcctcgagca gctgcaggag     1320

tacgccgacg cggacctgag cgtggtcgag aagctcaagg agatcatcat ccagaaggtc     1380

gacgagatct acaaggtgta cggctccagc gagaagctct tcgacgcgga cttcgtcctc     1440

gagaagtccc tgaagaagaa cgacgccgtg gtcgcgatca tgaaggacct cctggactcc     1500

gtgaagagct tcgagaatta catcaaggcc ttcttcggcg agggcaagga gacgaacagg     1560

gacgagtcct tctacggcga cttcgtcctg gcctacgaca tcctcctgaa ggtggaccac     1620

atctacgacg cgatccgcaa ctacgtgacc cagaagccgt acagcaagga caagttcaag     1680

ctctacttcc agaaccccca gttcatgggc ggctgggaca aggacaagga gacggactac     1740

agggcgacca tcctgcgcta cggcagcaag tactacctcg ccatcatgga caagaagtac     1800

gcgaagtgcc tgcagaagat cgacaaggac gacgtcaacg gcaactacga gaagatcaac     1860

tacaagctcc tgccgggccc caacaagatg ctcccgaagg tgttcttctc caagaagtgg     1920

atggcctact acaaccccag cgaggacatc cagaagatct acaagaacgg cacgttcaag     1980

aagggcgaca tgttcaacct gaacgactgc cacaagctca tcgacttctt caaggactcc     2040

atcagccgct acccgaagtg gtccaacgcc tacgacttca acttcagcga gaccgagaag     2100

tacaaggaca tcgcgggctt ctaccgcgag gtcgaggagc agggctacaa ggtgtccttc     2160

gagtccgcca gcaagaagga ggtcgacaag ctggtggagg agggcaagct ctacatgttc     2220

cagatctaca acaaggactt ctccgacaag agccacggca cgcccaacct gcacaccatg     2280

tacttcaagc tcctgttcga cgagaacaac cacggccaga tcaggctgtc cggcggcgcc     2340

gagctcttca tgaggagggc gagcctgaag aaggaggagc tggtggtcca ccccgctaac     2400

agcccaatcg cgaacaagaa cccggacaac cccaagaaga ccacgaccct gtcctacgac     2460

gtgtacaagg acaagaggtt cagcgaggac cagtacgagc tccacatccc gatcgcgatc     2520

aacaagtgcc ccaagaacat cttcaagatc aacaccgagg tccgcgtgct cctgaagcac     2580

gacgacaacc cctacgtgat cggcatcgac aggggcgaga ggaacctcct gtacatcgtg     2640

gtcgtggacg gcaagggcaa catcgtggag cagtactccc tcaacgagat catcaacaac     2700

ttcaacggca tcaggatcaa gacggactac cacagcctcc tggacaagaa ggagaaggag     2760

aggttcgagg cccgccagaa ctggacctcc atcgagaaca tcaaggagct gaaggcgggc     2820

tacatcagcc aggtcgtgca caagatctgc gagctcgtcg agaagtacga cgccgtgatc     2880

gccctcgagg acctgaactc cggcttcaag aacagccgcg tcaaggtgga gaagcaggtc     2940

taccagaagt tcgagaagat gctcatcgac aagctgaact acatggtgga caagaagtcc     3000

aacccctgcg ctacgggcgg cgcgctgaag ggctaccaga tcaccaacaa gttcgagagc     3060

ttcaagtcca tgagcactca gaacggcttc atcttctaca tcccggcgtg gctcacgtcc     3120

aagatcgacc ccagcaccgg cttcgtcaac ctcctgaaga cgaagtacac ctccatcgcc     3180

gacagcaaga agttcatctc cagcttcgac cgcatcatgt atgtgccgga ggaggacctg     3240

ttcgagttcg ccctcgacta caagaacttc tcccgcacgg acgcggacta catcaagaag     3300

tggaagctgt acagctacgg caaccgcatc cgcatcttca ggaaccccaa gaagaacaac     3360

gtcttcgact gggaggaggt gtgcctgacc tccgcgtaca aggagctctt caacaagtac     3420

ggcatcaact accagcaggg cgacatcagg gctctcctgt gcgagcagag cgacaaggcc     3480

ttctactcca gcttcatggc gctgatgtcc ctcatgctgc agatgaggaa ctcgatcacc     3540

ggcaggacgg acgtggactt cctcatctcc ccggtgaaga acagcgacgg catcttctac     3600

gactccagga actacgaggc ccaggagaac gcgatcctcc caaagaacgc ggacgccaac     3660

ggcgcctaca acatcgccag gaaggtcctc tgggctatcg gccagttcaa gaaggcggag     3720

gacgagaagc tggacaaggt gaagatcgcc atcagcaaca aggagtggct cgagtacgcc     3780

cagacctcgg tcaagcacgg cagcccgaag aagaagcgca aggtgtccgg cggcagctcc     3840

ggcggcagcc cgaagaagaa gcgcaaagtg tga                                  3873


<210>  56
<211>  1290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  56

Met Pro Lys Lys Lys Arg Lys Val Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn Cys 
        35                  40                  45              


Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys 
    50                  55                  60                  


Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys 
65                  70                  75                  80  


Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr 
                85                  90                  95      


Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu 
            100                 105                 110         


Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu 
        115                 120                 125             


Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala 
    130                 135                 140                 


Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp 
145                 150                 155                 160 


Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile 
                165                 170                 175     


Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe 
            180                 185                 190         


Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser 
        195                 200                 205             


Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn 
    210                 215                 220                 


Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val 
225                 230                 235                 240 


Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp 
                245                 250                 255     


Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile 
            260                 265                 270         


Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu 
        275                 280                 285             


Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr 
    290                 295                 300                 


Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser 
305                 310                 315                 320 


Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu 
                325                 330                 335     


Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile 
            340                 345                 350         


Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu 
        355                 360                 365             


Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr 
    370                 375                 380                 


Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp 
385                 390                 395                 400 


Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr 
                405                 410                 415     


Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser 
            420                 425                 430         


Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val 
        435                 440                 445             


Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr 
    450                 455                 460                 


Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu 
465                 470                 475                 480 


Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp 
                485                 490                 495     


Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe 
            500                 505                 510         


Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe 
        515                 520                 525             


Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala 
    530                 535                 540                 


Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys 
545                 550                 555                 560 


Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys 
                565                 570                 575     


Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr 
            580                 585                 590         


Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp 
        595                 600                 605             


Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu 
    610                 615                 620                 


Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp 
625                 630                 635                 640 


Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn 
                645                 650                 655     


Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys 
            660                 665                 670         


Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser 
        675                 680                 685             


Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile 
    690                 695                 700                 


Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe 
705                 710                 715                 720 


Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys 
                725                 730                 735     


Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His 
            740                 745                 750         


Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu 
        755                 760                 765             


Asn Asn His Gly Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met 
    770                 775                 780                 


Arg Arg Ala Ser Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn 
785                 790                 795                 800 


Ser Pro Ile Ala Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr 
                805                 810                 815     


Leu Ser Tyr Asp Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr 
            820                 825                 830         


Glu Leu His Ile Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe 
        835                 840                 845             


Lys Ile Asn Thr Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro 
    850                 855                 860                 


Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val 
865                 870                 875                 880 


Val Val Asp Gly Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu 
                885                 890                 895     


Ile Ile Asn Asn Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser 
            900                 905                 910         


Leu Leu Asp Lys Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp 
        915                 920                 925             


Thr Ser Ile Glu Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln 
    930                 935                 940                 


Val Val His Lys Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile 
945                 950                 955                 960 


Ala Leu Glu Asp Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val 
                965                 970                 975     


Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu 
            980                 985                 990         


Asn Tyr Met Val Asp Lys Lys Ser  Asn Pro Cys Ala Thr  Gly Gly Ala 
        995                 1000                 1005             


Leu Lys  Gly Tyr Gln Ile Thr  Asn Lys Phe Glu Ser  Phe Lys Ser 
    1010                 1015                 1020             


Met Ser  Thr Gln Asn Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu 
    1025                 1030                 1035             


Thr Ser  Lys Ile Asp Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys 
    1040                 1045                 1050             


Thr Lys  Tyr Thr Ser Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser 
    1055                 1060                 1065             


Phe Asp  Arg Ile Met Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe 
    1070                 1075                 1080             


Ala Leu  Asp Tyr Lys Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile 
    1085                 1090                 1095             


Lys Lys  Trp Lys Leu Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe 
    1100                 1105                 1110             


Arg Asn  Pro Lys Lys Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys 
    1115                 1120                 1125             


Leu Thr  Ser Ala Tyr Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn 
    1130                 1135                 1140             


Tyr Gln  Gln Gly Asp Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp 
    1145                 1150                 1155             


Lys Ala  Phe Tyr Ser Ser Phe  Met Ala Leu Met Ser  Leu Met Leu 
    1160                 1165                 1170             


Gln Met  Arg Asn Ser Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu 
    1175                 1180                 1185             


Ile Ser  Pro Val Lys Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg 
    1190                 1195                 1200             


Asn Tyr  Glu Ala Gln Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp 
    1205                 1210                 1215             


Ala Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile 
    1220                 1225                 1230             


Gly Gln  Phe Lys Lys Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys 
    1235                 1240                 1245             


Ile Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser 
    1250                 1255                 1260             


Val Lys  His Gly Ser Pro Lys  Lys Lys Arg Lys Val  Ser Gly Gly 
    1265                 1270                 1275             


Ser Ser  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  
    1280                 1285                 1290 


<210>  57
<211>  1491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Met Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro 
        35                  40                  45              


Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp 
    50                  55                  60                  


Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp 
65                  70                  75                  80  


Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys 
                85                  90                  95      


His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe 
            100                 105                 110         


Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro 
        115                 120                 125             


Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro 
    130                 135                 140                 


His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp 
145                 150                 155                 160 


Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr 
                165                 170                 175     


Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe 
            180                 185                 190         


Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His 
        195                 200                 205             


Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly 
    210                 215                 220                 


Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr 
225                 230                 235                 240 


Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro 
                245                 250                 255     


His Ile Leu Trp Ala Thr Gly Leu Lys Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn 
    290                 295                 300                 


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
305                 310                 315                 320 


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
                325                 330                 335     


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
            340                 345                 350         


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
        355                 360                 365             


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
    370                 375                 380                 


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
385                 390                 395                 400 


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
                405                 410                 415     


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
            420                 425                 430         


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
        435                 440                 445             


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
    450                 455                 460                 


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
465                 470                 475                 480 


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
                485                 490                 495     


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
            500                 505                 510         


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
        515                 520                 525             


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
    530                 535                 540                 


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
545                 550                 555                 560 


Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu 
                565                 570                 575     


Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp 
            580                 585                 590         


Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu 
        595                 600                 605             


Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp 
    610                 615                 620                 


Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser 
625                 630                 635                 640 


Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys 
                645                 650                 655     


Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val 
            660                 665                 670         


Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly 
        675                 680                 685             


Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser 
    690                 695                 700                 


Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile 
705                 710                 715                 720 


Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val 
                725                 730                 735     


Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys 
            740                 745                 750         


Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe 
        755                 760                 765             


Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp 
    770                 775                 780                 


Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp 
785                 790                 795                 800 


Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe 
                805                 810                 815     


Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp 
            820                 825                 830         


Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr 
        835                 840                 845             


Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile 
    850                 855                 860                 


Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu 
865                 870                 875                 880 


Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys 
                885                 890                 895     


Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys 
            900                 905                 910         


Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His 
        915                 920                 925             


Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp 
    930                 935                 940                 


Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp 
945                 950                 955                 960 


Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser 
                965                 970                 975     


Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly 
            980                 985                 990         


Lys Leu Tyr Met Phe Gln Ile Tyr  Asn Lys Asp Phe Ser  Asp Lys Ser 
        995                 1000                 1005             


His Gly  Thr Pro Asn Leu His  Thr Met Tyr Phe Lys  Leu Leu Phe 
    1010                 1015                 1020             


Asp Glu  Asn Asn His Gly Gln  Ile Arg Leu Ser Gly  Gly Ala Glu 
    1025                 1030                 1035             


Leu Phe  Met Arg Arg Ala Ser  Leu Lys Lys Glu Glu  Leu Val Val 
    1040                 1045                 1050             


His Pro  Ala Asn Ser Pro Ile  Ala Asn Lys Asn Pro  Asp Asn Pro 
    1055                 1060                 1065             


Lys Lys  Thr Thr Thr Leu Ser  Tyr Asp Val Tyr Lys  Asp Lys Arg 
    1070                 1075                 1080             


Phe Ser  Glu Asp Gln Tyr Glu  Leu His Ile Pro Ile  Ala Ile Asn 
    1085                 1090                 1095             


Lys Cys  Pro Lys Asn Ile Phe  Lys Ile Asn Thr Glu  Val Arg Val 
    1100                 1105                 1110             


Leu Leu  Lys His Asp Asp Asn  Pro Tyr Val Ile Gly  Ile Ala Arg 
    1115                 1120                 1125             


Gly Glu  Arg Asn Leu Leu Tyr  Ile Val Val Val Asp  Gly Lys Gly 
    1130                 1135                 1140             


Asn Ile  Val Glu Gln Tyr Ser  Leu Asn Glu Ile Ile  Asn Asn Phe 
    1145                 1150                 1155             


Asn Gly  Ile Arg Ile Lys Thr  Asp Tyr His Ser Leu  Leu Asp Lys 
    1160                 1165                 1170             


Lys Glu  Lys Glu Arg Phe Glu  Ala Arg Gln Asn Trp  Thr Ser Ile 
    1175                 1180                 1185             


Glu Asn  Ile Lys Glu Leu Lys  Ala Gly Tyr Ile Ser  Gln Val Val 
    1190                 1195                 1200             


His Lys  Ile Cys Glu Leu Val  Glu Lys Tyr Asp Ala  Val Ile Ala 
    1205                 1210                 1215             


Leu Ala  Asp Leu Asn Ser Gly  Phe Lys Asn Ser Arg  Val Lys Val 
    1220                 1225                 1230             


Glu Lys  Gln Val Tyr Gln Lys  Phe Glu Lys Met Leu  Ile Asp Lys 
    1235                 1240                 1245             


Leu Asn  Tyr Met Val Asp Lys  Lys Ser Asn Pro Cys  Ala Thr Gly 
    1250                 1255                 1260             


Gly Ala  Leu Lys Gly Tyr Gln  Ile Thr Asn Lys Phe  Glu Ser Phe 
    1265                 1270                 1275             


Lys Ser  Met Ser Thr Gln Asn  Gly Phe Ile Phe Tyr  Ile Pro Ala 
    1280                 1285                 1290             


Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr Gly Phe  Val Asn Leu 
    1295                 1300                 1305             


Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp Ser Lys  Lys Phe Ile 
    1310                 1315                 1320             


Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro Glu Glu  Asp Leu Phe 
    1325                 1330                 1335             


Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser Arg Thr  Asp Ala Asp 
    1340                 1345                 1350             


Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr Gly Asn  Arg Ile Arg 
    1355                 1360                 1365             


Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val Phe Asp  Trp Glu Glu 
    1370                 1375                 1380             


Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu Phe Asn  Lys Tyr Gly 
    1385                 1390                 1395             


Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala Leu Leu  Cys Glu Gln 
    1400                 1405                 1410             


Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met Ala Leu  Met Ser Leu 
    1415                 1420                 1425             


Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly Arg Thr  Asp Val Ala 
    1430                 1435                 1440             


Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp Gly Ile  Phe Tyr Asp 
    1445                 1450                 1455             


Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala Ile Leu  Pro Lys Asn 
    1460                 1465                 1470             


Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala Arg Lys  Val Leu Trp 
    1475                 1480                 1485             


Ala Ile  Gly 
    1490     


<210>  58
<211>  1662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Pro 
            20                  25                  30          


Lys Lys Lys Arg Lys Val Met Ser Ser Glu Thr Gly Pro Val Ala Val 
        35                  40                  45              


Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val Phe 
    50                  55                  60                  


Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu Ile 
65                  70                  75                  80  


Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln Asn Thr 
                85                  90                  95      


Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu Arg 
            100                 105                 110         


Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser Trp 
        115                 120                 125             


Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser Arg 
    130                 135                 140                 


Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His His 
145                 150                 155                 160 


Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser Gly 
                165                 170                 175     


Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp Arg 
            180                 185                 190         


Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg Tyr 
        195                 200                 205             


Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile Ile 
    210                 215                 220                 


Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro Gln 
225                 230                 235                 240 


Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg Leu 
                245                 250                 255     


Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Leu Phe Gln Asp Phe Thr 
    290                 295                 300                 


His Leu Tyr Pro Leu Ser Lys Thr Val Arg Phe Glu Leu Lys Pro Ile 
305                 310                 315                 320 


Gly Arg Thr Leu Glu His Ile His Ala Lys Asn Phe Leu Ser Gln Asp 
                325                 330                 335     


Glu Thr Met Ala Asp Met Tyr Gln Lys Val Lys Val Ile Leu Asp Asp 
            340                 345                 350         


Tyr His Arg Asp Phe Ile Ala Asp Met Met Gly Glu Val Lys Leu Thr 
        355                 360                 365             


Lys Leu Ala Glu Phe Tyr Asp Val Tyr Leu Lys Phe Arg Lys Asn Pro 
    370                 375                 380                 


Lys Asp Asp Gly Leu Gln Lys Gln Leu Lys Asp Leu Gln Ala Val Leu 
385                 390                 395                 400 


Arg Lys Glu Ser Val Lys Pro Ile Gly Ser Gly Gly Lys Tyr Lys Thr 
                405                 410                 415     


Gly Tyr Asp Arg Leu Phe Gly Ala Lys Leu Phe Lys Asp Gly Lys Glu 
            420                 425                 430         


Leu Gly Asp Leu Ala Lys Phe Val Ile Ala Gln Glu Gly Glu Ser Ser 
        435                 440                 445             


Pro Lys Leu Ala His Leu Ala His Phe Glu Lys Phe Ser Thr Tyr Phe 
    450                 455                 460                 


Thr Gly Phe His Asp Asn Arg Lys Asn Met Tyr Ser Asp Glu Asp Lys 
465                 470                 475                 480 


His Thr Ala Ile Ala Tyr Arg Leu Ile His Glu Asn Leu Pro Arg Phe 
                485                 490                 495     


Ile Asp Asn Leu Gln Ile Leu Thr Thr Ile Lys Gln Lys His Ser Ala 
            500                 505                 510         


Leu Tyr Asp Gln Ile Ile Asn Glu Leu Thr Ala Ser Gly Leu Asp Val 
        515                 520                 525             


Ser Leu Ala Ser His Leu Asp Gly Tyr His Lys Leu Leu Thr Gln Glu 
    530                 535                 540                 


Gly Ile Thr Ala Tyr Asn Arg Ile Ile Gly Glu Val Asn Gly Tyr Thr 
545                 550                 555                 560 


Asn Lys His Asn Gln Ile Cys His Lys Ser Glu Arg Ile Ala Lys Leu 
                565                 570                 575     


Arg Pro Leu His Lys Gln Ile Leu Ser Asp Gly Met Gly Val Ser Phe 
            580                 585                 590         


Leu Pro Ser Lys Phe Ala Asp Asp Ser Glu Met Cys Gln Ala Val Asn 
        595                 600                 605             


Glu Phe Tyr Arg His Tyr Thr Asp Val Phe Ala Lys Val Gln Ser Leu 
    610                 615                 620                 


Phe Asp Gly Phe Asp Asp His Gln Lys Asp Gly Ile Tyr Val Glu His 
625                 630                 635                 640 


Lys Asn Leu Asn Glu Leu Ser Lys Gln Ala Phe Gly Asp Phe Ala Leu 
                645                 650                 655     


Leu Gly Arg Val Leu Asp Gly Tyr Tyr Val Asp Val Val Asn Pro Glu 
            660                 665                 670         


Phe Asn Glu Arg Phe Ala Lys Ala Lys Thr Asp Asn Ala Lys Ala Lys 
        675                 680                 685             


Leu Thr Lys Glu Lys Asp Lys Phe Ile Lys Gly Val His Ser Leu Ala 
    690                 695                 700                 


Ser Leu Glu Gln Ala Ile Glu His His Thr Ala Arg His Asp Asp Glu 
705                 710                 715                 720 


Ser Val Gln Ala Gly Lys Leu Gly Gln Tyr Phe Lys His Gly Leu Ala 
                725                 730                 735     


Gly Val Asp Asn Pro Ile Gln Lys Ile His Asn Asn His Ser Thr Ile 
            740                 745                 750         


Lys Gly Phe Leu Glu Arg Glu Arg Pro Ala Gly Glu Arg Ala Leu Pro 
        755                 760                 765             


Lys Ile Lys Ser Gly Lys Asn Pro Glu Met Thr Gln Leu Arg Gln Leu 
    770                 775                 780                 


Lys Glu Leu Leu Asp Asn Ala Leu Asn Val Ala His Phe Ala Lys Leu 
785                 790                 795                 800 


Leu Thr Thr Lys Thr Thr Leu Asp Asn Gln Asp Gly Asn Phe Tyr Gly 
                805                 810                 815     


Glu Phe Gly Val Leu Tyr Asp Glu Leu Ala Lys Ile Pro Thr Leu Tyr 
            820                 825                 830         


Asn Lys Val Arg Asp Tyr Leu Ser Gln Lys Pro Phe Ser Thr Glu Lys 
        835                 840                 845             


Tyr Lys Leu Asn Phe Gly Asn Pro Thr Leu Leu Asn Gly Trp Asp Leu 
    850                 855                 860                 


Asn Lys Glu Lys Asp Asn Phe Gly Val Ile Leu Gln Lys Asp Gly Cys 
865                 870                 875                 880 


Tyr Tyr Leu Ala Leu Leu Asp Lys Ala His Lys Lys Val Phe Asp Asn 
                885                 890                 895     


Ala Pro Asn Thr Gly Lys Asn Val Tyr Gln Lys Met Val Tyr Lys Leu 
            900                 905                 910         


Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ala Lys Ser 
        915                 920                 925             


Asn Leu Asp Tyr Tyr Asn Pro Ser Ala Glu Leu Leu Asp Lys Tyr Ala 
    930                 935                 940                 


Lys Gly Thr His Lys Lys Gly Asp Asn Phe Asn Leu Lys Asp Cys His 
945                 950                 955                 960 


Ala Leu Ile Asp Phe Phe Lys Ala Gly Ile Asn Lys His Pro Glu Trp 
                965                 970                 975     


Gln His Phe Gly Phe Lys Phe Ser Pro Thr Ser Ser Tyr Arg Asp Leu 
            980                 985                 990         


Ser Asp Phe Tyr Arg Glu Val Glu  Pro Gln Gly Tyr Gln  Val Lys Phe 
        995                 1000                 1005             


Val Asp  Ile Asn Ala Asp Tyr  Ile Asp Glu Leu Val  Glu Gln Gly 
    1010                 1015                 1020             


Lys Leu  Tyr Leu Phe Gln Ile  Tyr Asn Lys Asp Phe  Ser Pro Lys 
    1025                 1030                 1035             


Ala His  Gly Lys Pro Asn Leu  His Thr Leu Tyr Phe  Lys Ala Leu 
    1040                 1045                 1050             


Phe Ser  Glu Asp Asn Leu Ala  Asp Pro Ile Tyr Lys  Leu Asn Gly 
    1055                 1060                 1065             


Glu Ala  Gln Ile Phe Tyr Arg  Lys Ala Ser Leu Asp  Met Asn Glu 
    1070                 1075                 1080             


Thr Thr  Ile His Arg Ala Gly  Glu Val Leu Glu Asn  Lys Asn Pro 
    1085                 1090                 1095             


Asp Asn  Pro Lys Lys Arg Gln  Phe Val Tyr Asp Ile  Ile Lys Asp 
    1100                 1105                 1110             


Lys Arg  Tyr Thr Gln Asp Lys  Phe Met Leu His Val  Pro Ile Thr 
    1115                 1120                 1125             


Met Asn  Phe Gly Val Gln Gly  Met Thr Ile Lys Glu  Phe Asn Lys 
    1130                 1135                 1140             


Lys Val  Asn Gln Ser Ile Gln  Gln Tyr Asp Glu Val  Asn Val Ile 
    1145                 1150                 1155             


Gly Ile  Ala Arg Gly Glu Arg  His Leu Leu Tyr Leu  Thr Val Ile 
    1160                 1165                 1170             


Asn Ser  Lys Gly Glu Ile Leu  Glu Gln Arg Ser Leu  Asn Asp Ile 
    1175                 1180                 1185             


Thr Thr  Ala Ser Ala Asn Gly  Thr Gln Val Thr Thr  Pro Tyr His 
    1190                 1195                 1200             


Lys Ile  Leu Asp Lys Arg Glu  Ile Glu Arg Leu Asn  Ala Arg Val 
    1205                 1210                 1215             


Gly Trp  Gly Glu Ile Glu Thr  Ile Lys Glu Leu Lys  Ser Gly Tyr 
    1220                 1225                 1230             


Leu Ser  His Val Val His Gln  Ile Asn Gln Leu Met  Leu Lys Tyr 
    1235                 1240                 1245             


Asn Ala  Ile Val Val Leu Ala  Asp Leu Asn Phe Gly  Phe Lys Arg 
    1250                 1255                 1260             


Gly Arg  Phe Lys Val Glu Lys  Gln Ile Tyr Gln Asn  Phe Glu Asn 
    1265                 1270                 1275             


Ala Leu  Ile Lys Lys Leu Asn  His Leu Val Leu Lys  Asp Lys Ala 
    1280                 1285                 1290             


Asp Asp  Glu Ile Gly Ser Tyr  Lys Asn Ala Leu Gln  Leu Thr Asn 
    1295                 1300                 1305             


Asn Phe  Thr Asp Leu Lys Ser  Ile Gly Lys Gln Thr  Gly Phe Leu 
    1310                 1315                 1320             


Phe Tyr  Val Pro Ala Trp Asn  Thr Ser Lys Ile Asp  Pro Glu Thr 
    1325                 1330                 1335             


Gly Phe  Val Asp Leu Leu Lys  Pro Arg Tyr Glu Asn  Ile Ala Gln 
    1340                 1345                 1350             


Ser Gln  Ala Phe Phe Gly Lys  Phe Asp Lys Ile Cys  Tyr Asn Thr 
    1355                 1360                 1365             


Asp Lys  Gly Tyr Phe Glu Phe  His Ile Asp Tyr Ala  Lys Phe Thr 
    1370                 1375                 1380             


Asp Lys  Ala Lys Asn Ser Arg  Gln Lys Trp Ala Ile  Cys Ser His 
    1385                 1390                 1395             


Gly Asp  Lys Arg Tyr Val Tyr  Asp Lys Thr Ala Asn  Gln Asn Lys 
    1400                 1405                 1410             


Gly Ala  Ala Lys Gly Ile Asn  Val Asn Asp Glu Leu  Lys Ser Leu 
    1415                 1420                 1425             


Phe Ala  Arg Tyr His Ile Asn  Asp Lys Gln Pro Asn  Leu Val Met 
    1430                 1435                 1440             


Asp Ile  Cys Gln Asn Asn Asp  Lys Glu Phe His Lys  Ser Leu Met 
    1445                 1450                 1455             


Cys Leu  Leu Lys Thr Leu Leu  Ala Leu Arg Tyr Ser  Asn Ala Ser 
    1460                 1465                 1470             


Ser Asp  Glu Ala Phe Ile Leu  Ser Pro Val Ala Asn  Asp Glu Gly 
    1475                 1480                 1485             


Val Phe  Phe Asn Ser Ala Leu  Ala Asp Asp Thr Gln  Pro Gln Asn 
    1490                 1495                 1500             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Trp 
    1505                 1510                 1515             


Leu Leu  Asn Glu Leu Lys Asn  Ser Asp Asp Leu Asn  Lys Val Lys 
    1520                 1525                 1530             


Leu Ala  Ile Asp Asn Gln Thr  Trp Leu Asn Phe Ala  Gln Asn Arg 
    1535                 1540                 1545             


Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys 
    1550                 1555                 1560             


Lys Ser  Gly Gly Ser Thr Asn  Leu Ser Asp Ile Ile  Glu Lys Glu 
    1565                 1570                 1575             


Thr Gly  Lys Gln Leu Val Ile  Gln Glu Ser Ile Leu  Met Leu Pro 
    1580                 1585                 1590             


Glu Glu  Val Glu Glu Val Ile  Gly Asn Lys Pro Glu  Ser Asp Ile 
    1595                 1600                 1605             


Leu Val  His Thr Ala Tyr Asp  Glu Ser Thr Asp Glu  Asn Val Met 
    1610                 1615                 1620             


Leu Leu  Thr Ser Asp Ala Pro  Glu Tyr Lys Pro Trp  Ala Leu Val 
    1625                 1630                 1635             


Ile Gln  Asp Ser Asn Gly Glu  Asn Lys Ile Lys Met  Leu Ser Gly 
    1640                 1645                 1650             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1655                 1660         


<210>  59
<211>  1267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Met Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val 
            20                  25                  30          


Arg Phe Glu Leu Lys Pro Ile Gly Arg Thr Leu Glu His Ile His Ala 
        35                  40                  45              


Lys Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp Met Tyr Gln Lys 
    50                  55                  60                  


Val Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met 
65                  70                  75                  80  


Met Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr 
                85                  90                  95      


Leu Lys Phe Arg Lys Asn Pro Lys Asp Asp Gly Leu Gln Lys Gln Leu 
            100                 105                 110         


Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ser Val Lys Pro Ile Gly 
        115                 120                 125             


Ser Gly Gly Lys Tyr Lys Thr Gly Tyr Asp Arg Leu Phe Gly Ala Lys 
    130                 135                 140                 


Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile 
145                 150                 155                 160 


Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His Leu Ala His Phe 
                165                 170                 175     


Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn 
            180                 185                 190         


Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile 
        195                 200                 205             


His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr 
    210                 215                 220                 


Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu 
225                 230                 235                 240 


Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr 
                245                 250                 255     


His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr Asn Arg Ile Ile 
            260                 265                 270         


Gly Glu Val Asn Gly Tyr Thr Asn Lys His Asn Gln Ile Cys His Lys 
        275                 280                 285             


Ser Glu Arg Ile Ala Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser 
    290                 295                 300                 


Asp Gly Met Gly Val Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser 
305                 310                 315                 320 


Glu Met Cys Gln Ala Val Asn Glu Phe Tyr Arg His Tyr Thr Asp Val 
                325                 330                 335     


Phe Ala Lys Val Gln Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys 
            340                 345                 350         


Asp Gly Ile Tyr Val Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln 
        355                 360                 365             


Ala Phe Gly Asp Phe Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr 
    370                 375                 380                 


Val Asp Val Val Asn Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys 
385                 390                 395                 400 


Thr Asp Asn Ala Lys Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile 
                405                 410                 415     


Lys Gly Val His Ser Leu Ala Ser Leu Glu Gln Ala Ile Glu His His 
            420                 425                 430         


Thr Ala Arg His Asp Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln 
        435                 440                 445             


Tyr Phe Lys His Gly Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile 
    450                 455                 460                 


His Asn Asn His Ser Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Ala Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu 
                485                 490                 495     


Met Thr Gln Leu Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn 
            500                 505                 510         


Val Ala His Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn 
        515                 520                 525             


Gln Asp Gly Asn Phe Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu 
    530                 535                 540                 


Ala Lys Ile Pro Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln 
545                 550                 555                 560 


Lys Pro Phe Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr 
                565                 570                 575     


Leu Leu Asn Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val 
            580                 585                 590         


Ile Leu Gln Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala 
        595                 600                 605             


His Lys Lys Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Asn Val Tyr 
    610                 615                 620                 


Gln Lys Met Val Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro 
625                 630                 635                 640 


Lys Val Phe Phe Ala Lys Ser Asn Leu Asp Tyr Tyr Asn Pro Ser Ala 
                645                 650                 655     


Glu Leu Leu Asp Lys Tyr Ala Lys Gly Thr His Lys Lys Gly Asp Asn 
            660                 665                 670         


Phe Asn Leu Lys Asp Cys His Ala Leu Ile Asp Phe Phe Lys Ala Gly 
        675                 680                 685             


Ile Asn Lys His Pro Glu Trp Gln His Phe Gly Phe Lys Phe Ser Pro 
    690                 695                 700                 


Thr Ser Ser Tyr Arg Asp Leu Ser Asp Phe Tyr Arg Glu Val Glu Pro 
705                 710                 715                 720 


Gln Gly Tyr Gln Val Lys Phe Val Asp Ile Asn Ala Asp Tyr Ile Asp 
                725                 730                 735     


Glu Leu Val Glu Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
            740                 745                 750         


Asp Phe Ser Pro Lys Ala His Gly Lys Pro Asn Leu His Thr Leu Tyr 
        755                 760                 765             


Phe Lys Ala Leu Phe Ser Glu Asp Asn Leu Ala Asp Pro Ile Tyr Lys 
    770                 775                 780                 


Leu Asn Gly Glu Ala Gln Ile Phe Tyr Arg Lys Ala Ser Leu Asp Met 
785                 790                 795                 800 


Asn Glu Thr Thr Ile His Arg Ala Gly Glu Val Leu Glu Asn Lys Asn 
                805                 810                 815     


Pro Asp Asn Pro Lys Lys Arg Gln Phe Val Tyr Asp Ile Ile Lys Asp 
            820                 825                 830         


Lys Arg Tyr Thr Gln Asp Lys Phe Met Leu His Val Pro Ile Thr Met 
        835                 840                 845             


Asn Phe Gly Val Gln Gly Met Thr Ile Lys Glu Phe Asn Lys Lys Val 
    850                 855                 860                 


Asn Gln Ser Ile Gln Gln Tyr Asp Glu Val Asn Val Ile Gly Ile Asp 
865                 870                 875                 880 


Arg Gly Glu Arg His Leu Leu Tyr Leu Thr Val Ile Asn Ser Lys Gly 
                885                 890                 895     


Glu Ile Leu Glu Gln Arg Ser Leu Asn Asp Ile Thr Thr Ala Ser Ala 
            900                 905                 910         


Asn Gly Thr Gln Val Thr Thr Pro Tyr His Lys Ile Leu Asp Lys Arg 
        915                 920                 925             


Glu Ile Glu Arg Leu Asn Ala Arg Val Gly Trp Gly Glu Ile Glu Thr 
    930                 935                 940                 


Ile Lys Glu Leu Lys Ser Gly Tyr Leu Ser His Val Val His Gln Ile 
945                 950                 955                 960 


Asn Gln Leu Met Leu Lys Tyr Asn Ala Ile Val Val Leu Glu Asp Leu 
                965                 970                 975     


Asn Phe Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln Ile Tyr 
            980                 985                 990         


Gln Asn Phe Glu Asn Ala Leu Ile  Lys Lys Leu Asn His  Leu Val Leu 
        995                 1000                 1005             


Lys Asp  Lys Ala Asp Asp Glu  Ile Gly Ser Tyr Lys  Asn Ala Leu 
    1010                 1015                 1020             


Gln Leu  Thr Asn Asn Phe Thr  Asp Leu Lys Ser Ile  Gly Lys Gln 
    1025                 1030                 1035             


Thr Gly  Phe Leu Phe Tyr Val  Pro Ala Trp Asn Thr  Ser Lys Ile 
    1040                 1045                 1050             


Asp Pro  Glu Thr Gly Phe Val  Asp Leu Leu Lys Pro  Arg Tyr Glu 
    1055                 1060                 1065             


Asn Ile  Ala Gln Ser Gln Ala  Phe Phe Gly Lys Phe  Asp Lys Ile 
    1070                 1075                 1080             


Cys Tyr  Asn Thr Asp Lys Gly  Tyr Phe Glu Phe His  Ile Asp Tyr 
    1085                 1090                 1095             


Ala Lys  Phe Thr Asp Lys Ala  Lys Asn Ser Arg Gln  Lys Trp Ala 
    1100                 1105                 1110             


Ile Cys  Ser His Gly Asp Lys  Arg Tyr Val Tyr Asp  Lys Thr Ala 
    1115                 1120                 1125             


Asn Gln  Asn Lys Gly Ala Ala  Lys Gly Ile Asn Val  Asn Asp Glu 
    1130                 1135                 1140             


Leu Lys  Ser Leu Phe Ala Arg  Tyr His Ile Asn Asp  Lys Gln Pro 
    1145                 1150                 1155             


Asn Leu  Val Met Asp Ile Cys  Gln Asn Asn Asp Lys  Glu Phe His 
    1160                 1165                 1170             


Lys Ser  Leu Met Cys Leu Leu  Lys Thr Leu Leu Ala  Leu Arg Tyr 
    1175                 1180                 1185             


Ser Asn  Ala Ser Ser Asp Glu  Asp Phe Ile Leu Ser  Pro Val Ala 
    1190                 1195                 1200             


Asn Asp  Glu Gly Val Phe Phe  Asn Ser Ala Leu Ala  Asp Asp Thr 
    1205                 1210                 1215             


Gln Pro  Gln Asn Ala Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu 
    1220                 1225                 1230             


Lys Gly  Leu Trp Leu Leu Asn  Glu Leu Lys Asn Ser  Asp Asp Leu 
    1235                 1240                 1245             


Asn Lys  Val Lys Leu Ala Ile  Asp Asn Gln Thr Trp  Leu Asn Phe 
    1250                 1255                 1260             


Ala Gln  Asn Arg 
    1265         


<210>  60
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
            20                  25                  30          


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
        35                  40                  45              


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
    50                  55                  60                  


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
65                  70                  75                  80  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
                85                  90                  95      


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
            100                 105                 110         


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
        115                 120                 125             


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
    130                 135                 140                 


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
145                 150                 155                 160 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
                165                 170                 175     


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
            180                 185                 190         


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
        195                 200                 205             


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
    210                 215                 220                 


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
225                 230                 235                 240 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
                245                 250                 255     


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
            260                 265                 270         


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
        275                 280                 285             


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
    290                 295                 300                 


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
305                 310                 315                 320 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
                325                 330                 335     


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
            340                 345                 350         


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
        355                 360                 365             


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
    370                 375                 380                 


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
385                 390                 395                 400 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
                405                 410                 415     


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
            420                 425                 430         


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
        435                 440                 445             


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
    450                 455                 460                 


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
465                 470                 475                 480 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
                485                 490                 495     


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
            500                 505                 510         


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
        515                 520                 525             


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
    530                 535                 540                 


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
545                 550                 555                 560 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
                565                 570                 575     


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
            580                 585                 590         


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
        595                 600                 605             


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
    610                 615                 620                 


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
625                 630                 635                 640 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
                645                 650                 655     


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
            660                 665                 670         


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
        675                 680                 685             


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
    690                 695                 700                 


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
705                 710                 715                 720 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
                725                 730                 735     


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
            740                 745                 750         


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
        755                 760                 765             


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
    770                 775                 780                 


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
785                 790                 795                 800 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
                805                 810                 815     


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
            820                 825                 830         


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
        835                 840                 845             


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
    850                 855                 860                 


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
865                 870                 875                 880 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
                885                 890                 895     


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
            900                 905                 910         


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
        915                 920                 925             


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
    930                 935                 940                 


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
945                 950                 955                 960 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
                965                 970                 975     


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
            980                 985                 990         


His Glu Ile Val Asp Leu Met Ile  His Tyr Gln Ala Val  Val Val Leu 
        995                 1000                 1005             


Glu Asn  Leu Asn Phe Gly Phe  Lys Ser Lys Arg Thr  Gly Ile Ala 
    1010                 1015                 1020             


Glu Lys  Ala Val Tyr Gln Gln  Phe Glu Lys Met Leu  Ile Asp Lys 
    1025                 1030                 1035             


Leu Asn  Cys Leu Val Leu Lys  Asp Tyr Pro Ala Glu  Lys Val Gly 
    1040                 1045                 1050             


Gly Val  Leu Asn Pro Tyr Gln  Leu Thr Asp Gln Phe  Thr Ser Phe 
    1055                 1060                 1065             


Ala Lys  Met Gly Thr Gln Ser  Gly Phe Leu Phe Tyr  Val Pro Ala 
    1070                 1075                 1080             


Pro Tyr  Thr Ser Lys Ile Asp  Pro Leu Thr Gly Phe  Val Asp Pro 
    1085                 1090                 1095             


Phe Val  Trp Lys Thr Ile Lys  Asn His Glu Ser Arg  Lys His Phe 
    1100                 1105                 1110             


Leu Glu  Gly Phe Asp Phe Leu  His Tyr Asp Val Lys  Thr Gly Asp 
    1115                 1120                 1125             


Phe Ile  Leu His Phe Lys Met  Asn Arg Asn Leu Ser  Phe Gln Arg 
    1130                 1135                 1140             


Gly Leu  Pro Gly Phe Met Pro  Ala Trp Asp Ile Val  Phe Glu Lys 
    1145                 1150                 1155             


Asn Glu  Thr Gln Phe Asp Ala  Lys Gly Thr Pro Phe  Ile Ala Gly 
    1160                 1165                 1170             


Lys Arg  Ile Val Pro Val Ile  Glu Asn His Arg Phe  Thr Gly Arg 
    1175                 1180                 1185             


Tyr Arg  Asp Leu Tyr Pro Ala  Asn Glu Leu Ile Ala  Leu Leu Glu 
    1190                 1195                 1200             


Glu Lys  Gly Ile Val Phe Arg  Asp Gly Ser Asn Ile  Leu Pro Lys 
    1205                 1210                 1215             


Leu Leu  Glu Asn Asp Asp Ser  His Ala Ile Asp Thr  Met Val Ala 
    1220                 1225                 1230             


Leu Ile  Arg Ser Val Leu Gln  Met Arg Asn Ser Asn  Ala Ala Thr 
    1235                 1240                 1245             


Gly Glu  Asp Tyr Ile Asn Ser  Pro Val Arg Asp Leu  Asn Gly Val 
    1250                 1255                 1260             


Cys Phe  Asp Ser Arg Phe Gln  Asn Pro Glu Trp Pro  Met Asp Ala 
    1265                 1270                 1275             


Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu Lys Gly  Gln Leu Leu 
    1280                 1285                 1290             


Leu Asn  His Leu Lys Glu Ser  Lys Asp Leu Lys Leu  Gln Asn Gly 
    1295                 1300                 1305             


Ile Ser  Asn Gln Asp Trp Leu  Ala Tyr Ile Gln Glu  Leu Arg Asn 
    1310                 1315                 1320             


Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys 
    1325                 1330                 1335             


Lys Gly  Ser Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr 
    1340                 1345                 1350             


Asp Val  Pro Asp Tyr Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    1355                 1360                 1365             


<210>  61
<211>  1332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
            20                  25                  30          


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
        35                  40                  45              


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
    50                  55                  60                  


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
65                  70                  75                  80  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
                85                  90                  95      


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
            100                 105                 110         


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
        115                 120                 125             


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
    130                 135                 140                 


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
145                 150                 155                 160 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
                165                 170                 175     


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
            180                 185                 190         


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
        195                 200                 205             


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
    210                 215                 220                 


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
225                 230                 235                 240 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
                245                 250                 255     


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
            260                 265                 270         


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
        275                 280                 285             


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
    290                 295                 300                 


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
305                 310                 315                 320 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
                325                 330                 335     


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
            340                 345                 350         


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
        355                 360                 365             


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
    370                 375                 380                 


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
385                 390                 395                 400 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
                405                 410                 415     


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
            420                 425                 430         


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
        435                 440                 445             


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
    450                 455                 460                 


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
465                 470                 475                 480 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
                485                 490                 495     


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
            500                 505                 510         


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
        515                 520                 525             


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
    530                 535                 540                 


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
545                 550                 555                 560 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
                565                 570                 575     


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
            580                 585                 590         


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
        595                 600                 605             


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
    610                 615                 620                 


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
625                 630                 635                 640 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
                645                 650                 655     


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
            660                 665                 670         


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
        675                 680                 685             


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
    690                 695                 700                 


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
705                 710                 715                 720 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
                725                 730                 735     


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
            740                 745                 750         


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
        755                 760                 765             


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
    770                 775                 780                 


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
785                 790                 795                 800 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
                805                 810                 815     


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
            820                 825                 830         


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
        835                 840                 845             


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
    850                 855                 860                 


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
865                 870                 875                 880 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
                885                 890                 895     


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
            900                 905                 910         


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Ala Arg Gly Glu Arg 
        915                 920                 925             


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
    930                 935                 940                 


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
945                 950                 955                 960 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
                965                 970                 975     


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
            980                 985                 990         


His Glu Ile Val Asp Leu Met Ile  His Tyr Gln Ala Val  Val Val Leu 
        995                 1000                 1005             


Ala Asn  Leu Asn Phe Gly Phe  Lys Ser Lys Arg Thr  Gly Ile Ala 
    1010                 1015                 1020             


Glu Lys  Ala Val Tyr Gln Gln  Phe Glu Lys Met Leu  Ile Asp Lys 
    1025                 1030                 1035             


Leu Asn  Cys Leu Val Leu Lys  Asp Tyr Pro Ala Glu  Lys Val Gly 
    1040                 1045                 1050             


Gly Val  Leu Asn Pro Tyr Gln  Leu Thr Asp Gln Phe  Thr Ser Phe 
    1055                 1060                 1065             


Ala Lys  Met Gly Thr Gln Ser  Gly Phe Leu Phe Tyr  Val Pro Ala 
    1070                 1075                 1080             


Pro Tyr  Thr Ser Lys Ile Asp  Pro Leu Thr Gly Phe  Val Asp Pro 
    1085                 1090                 1095             


Phe Val  Trp Lys Thr Ile Lys  Asn His Glu Ser Arg  Lys His Phe 
    1100                 1105                 1110             


Leu Glu  Gly Phe Asp Phe Leu  His Tyr Asp Val Lys  Thr Gly Asp 
    1115                 1120                 1125             


Phe Ile  Leu His Phe Lys Met  Asn Arg Asn Leu Ser  Phe Gln Arg 
    1130                 1135                 1140             


Gly Leu  Pro Gly Phe Met Pro  Ala Trp Asp Ile Val  Phe Glu Lys 
    1145                 1150                 1155             


Asn Glu  Thr Gln Phe Asp Ala  Lys Gly Thr Pro Phe  Ile Ala Gly 
    1160                 1165                 1170             


Lys Arg  Ile Val Pro Val Ile  Glu Asn His Arg Phe  Thr Gly Arg 
    1175                 1180                 1185             


Tyr Arg  Asp Leu Tyr Pro Ala  Asn Glu Leu Ile Ala  Leu Leu Glu 
    1190                 1195                 1200             


Glu Lys  Gly Ile Val Phe Arg  Asp Gly Ser Asn Ile  Leu Pro Lys 
    1205                 1210                 1215             


Leu Leu  Glu Asn Asp Asp Ser  His Ala Ile Asp Thr  Met Val Ala 
    1220                 1225                 1230             


Leu Ile  Arg Ser Val Leu Gln  Met Arg Asn Ser Asn  Ala Ala Thr 
    1235                 1240                 1245             


Gly Glu  Ala Tyr Ile Asn Ser  Pro Val Arg Asp Leu  Asn Gly Val 
    1250                 1255                 1260             


Cys Phe  Asp Ser Arg Phe Gln  Asn Pro Glu Trp Pro  Met Asp Ala 
    1265                 1270                 1275             


Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu Lys Gly  Gln Leu Leu 
    1280                 1285                 1290             


Leu Asn  His Leu Lys Glu Ser  Lys Asp Leu Lys Leu  Gln Asn Gly 
    1295                 1300                 1305             


Ile Ser  Asn Gln Asp Trp Leu  Ala Tyr Ile Gln Glu  Leu Arg Asn 
    1310                 1315                 1320             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1325                 1330         


<210>  62
<211>  1403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


Met Pro Lys Lys Lys Arg Lys Val Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Met Ser Ile Tyr Gln Glu Phe Val Asn Lys 
    50                  55                  60                  


Tyr Ser Leu Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys 
65                  70                  75                  80  


Thr Leu Glu Asn Ile Lys Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys 
                85                  90                  95      


Arg Ala Lys Asp Tyr Lys Lys Ala Lys Gln Ile Ile Asp Lys Tyr His 
            100                 105                 110         


Gln Phe Phe Ile Glu Glu Ile Leu Ser Ser Val Cys Ile Ser Glu Asp 
        115                 120                 125             


Leu Leu Gln Asn Tyr Ser Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp 
    130                 135                 140                 


Asp Asp Asn Leu Gln Lys Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys 
145                 150                 155                 160 


Lys Gln Ile Ser Glu Tyr Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu 
                165                 170                 175     


Phe Asn Gln Asn Leu Ile Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu 
            180                 185                 190         


Ile Leu Trp Leu Lys Gln Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys 
        195                 200                 205             


Ala Asn Ser Asp Ile Thr Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys 
    210                 215                 220                 


Ser Phe Lys Gly Trp Thr Thr Tyr Phe Lys Gly Phe His Glu Asn Arg 
225                 230                 235                 240 


Lys Asn Val Tyr Ser Ser Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg 
                245                 250                 255     


Ile Val Asp Asp Asn Leu Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr 
            260                 265                 270         


Glu Ser Leu Lys Asp Lys Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile 
        275                 280                 285             


Lys Lys Asp Leu Ala Glu Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr 
    290                 295                 300                 


Ser Glu Val Asn Gln Arg Val Phe Ser Leu Asp Glu Val Phe Glu Ile 
305                 310                 315                 320 


Ala Asn Phe Asn Asn Tyr Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn 
                325                 330                 335     


Thr Ile Ile Gly Gly Lys Phe Val Asn Gly Glu Asn Thr Lys Arg Lys 
            340                 345                 350         


Gly Ile Asn Glu Tyr Ile Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys 
        355                 360                 365             


Thr Leu Lys Lys Tyr Lys Met Ser Val Leu Phe Lys Gln Ile Leu Ser 
    370                 375                 380                 


Asp Thr Glu Ser Lys Ser Phe Val Ile Asp Lys Leu Glu Asp Asp Ser 
385                 390                 395                 400 


Asp Val Val Thr Thr Met Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe 
                405                 410                 415     


Lys Thr Val Glu Glu Lys Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe 
            420                 425                 430         


Asp Asp Leu Lys Ala Gln Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys 
        435                 440                 445             


Asn Asp Lys Ser Leu Thr Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr 
    450                 455                 460                 


Ser Val Ile Gly Thr Ala Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala 
465                 470                 475                 480 


Pro Lys Asn Leu Asp Asn Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala 
                485                 490                 495     


Lys Lys Thr Glu Lys Ala Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu 
            500                 505                 510         


Ala Leu Glu Glu Phe Asn Lys His Arg Asp Ile Asp Lys Gln Cys Arg 
        515                 520                 525             


Phe Glu Glu Ile Leu Ala Asn Phe Ala Ala Ile Pro Met Ile Phe Asp 
    530                 535                 540                 


Glu Ile Ala Gln Asn Lys Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr 
545                 550                 555                 560 


Gln Asn Gln Gly Lys Lys Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp 
                565                 570                 575     


Val Lys Ala Ile Lys Asp Leu Leu Asp Gln Thr Asn Asn Leu Leu His 
            580                 585                 590         


Lys Leu Lys Ile Phe His Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile 
        595                 600                 605             


Leu Asp Lys Asp Glu His Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe 
    610                 615                 620                 


Glu Leu Ala Asn Ile Val Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile 
625                 630                 635                 640 


Thr Gln Lys Pro Tyr Ser Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn 
                645                 650                 655     


Ser Thr Leu Ala Asn Gly Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr 
            660                 665                 670         


Ala Ile Leu Phe Ile Lys Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn 
        675                 680                 685             


Lys Lys Asn Asn Lys Ile Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys 
    690                 695                 700                 


Gly Glu Gly Tyr Lys Lys Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn 
705                 710                 715                 720 


Lys Met Leu Pro Lys Val Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr 
                725                 730                 735     


Asn Pro Ser Glu Asp Ile Leu Arg Ile Arg Asn His Ser Thr His Thr 
            740                 745                 750         


Lys Asn Gly Ser Pro Gln Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile 
        755                 760                 765             


Glu Asp Cys Arg Lys Phe Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys 
    770                 775                 780                 


His Pro Glu Trp Lys Asp Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg 
785                 790                 795                 800 


Tyr Asn Ser Ile Asp Glu Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr 
                805                 810                 815     


Lys Leu Thr Phe Glu Asn Ile Ser Glu Ser Tyr Ile Asp Ser Val Val 
            820                 825                 830         


Asn Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser 
        835                 840                 845             


Ala Tyr Ser Lys Gly Arg Pro Asn Leu His Thr Leu Tyr Trp Lys Ala 
    850                 855                 860                 


Leu Phe Asp Glu Arg Asn Leu Gln Asp Val Val Tyr Lys Leu Asn Gly 
865                 870                 875                 880 


Glu Ala Glu Leu Phe Tyr Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr 
                885                 890                 895     


His Pro Ala Lys Glu Ala Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys 
            900                 905                 910         


Lys Glu Ser Val Phe Glu Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr 
        915                 920                 925             


Glu Asp Lys Phe Phe Phe His Cys Pro Ile Thr Ile Asn Phe Lys Ser 
    930                 935                 940                 


Ser Gly Ala Asn Lys Phe Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu 
945                 950                 955                 960 


Lys Ala Asn Asp Val His Ile Leu Ser Ile Asp Arg Gly Glu Arg His 
                965                 970                 975     


Leu Ala Tyr Tyr Thr Leu Val Asp Gly Lys Gly Asn Ile Ile Lys Gln 
            980                 985                 990         


Asp Thr Phe Asn Ile Ile Gly Asn  Asp Arg Met Lys Thr  Asn Tyr His 
        995                 1000                 1005             


Asp Lys  Leu Ala Ala Ile Glu  Lys Asp Arg Asp Ser  Ala Arg Lys 
    1010                 1015                 1020             


Asp Trp  Lys Lys Ile Asn Asn  Ile Lys Glu Met Lys  Glu Gly Tyr 
    1025                 1030                 1035             


Leu Ser  Gln Val Val His Glu  Ile Ala Lys Leu Val  Ile Glu Tyr 
    1040                 1045                 1050             


Asn Ala  Ile Val Val Phe Glu  Asp Leu Asn Phe Gly  Phe Lys Arg 
    1055                 1060                 1065             


Gly Arg  Phe Lys Val Glu Lys  Gln Val Tyr Gln Lys  Leu Glu Lys 
    1070                 1075                 1080             


Met Leu  Ile Glu Lys Leu Asn  Tyr Leu Val Phe Lys  Asp Asn Glu 
    1085                 1090                 1095             


Phe Asp  Lys Thr Gly Gly Val  Leu Arg Ala Tyr Gln  Leu Thr Ala 
    1100                 1105                 1110             


Pro Phe  Glu Thr Phe Lys Lys  Met Gly Lys Gln Thr  Gly Ile Ile 
    1115                 1120                 1125             


Tyr Tyr  Val Pro Ala Gly Phe  Thr Ser Lys Ile Cys  Pro Val Thr 
    1130                 1135                 1140             


Gly Phe  Val Asn Gln Leu Tyr  Pro Lys Tyr Glu Ser  Val Ser Lys 
    1145                 1150                 1155             


Ser Gln  Glu Phe Phe Ser Lys  Phe Asp Lys Ile Cys  Tyr Asn Leu 
    1160                 1165                 1170             


Asp Lys  Gly Tyr Phe Glu Phe  Ser Phe Asp Tyr Lys  Asn Phe Gly 
    1175                 1180                 1185             


Asp Lys  Ala Ala Lys Gly Lys  Trp Thr Ile Ala Ser  Phe Gly Ser 
    1190                 1195                 1200             


Arg Leu  Ile Asn Phe Arg Asn  Ser Asp Lys Asn His  Asn Trp Asp 
    1205                 1210                 1215             


Thr Arg  Glu Val Tyr Pro Thr  Lys Glu Leu Glu Lys  Leu Leu Lys 
    1220                 1225                 1230             


Asp Tyr  Ser Ile Glu Tyr Gly  His Gly Glu Cys Ile  Lys Ala Ala 
    1235                 1240                 1245             


Ile Cys  Gly Glu Ser Asp Lys  Lys Phe Phe Ala Lys  Leu Thr Ser 
    1250                 1255                 1260             


Val Leu  Asn Thr Ile Leu Gln  Met Arg Asn Ser Lys  Thr Gly Thr 
    1265                 1270                 1275             


Glu Leu  Asp Tyr Leu Ile Ser  Pro Val Ala Asp Val  Asn Gly Asn 
    1280                 1285                 1290             


Phe Phe  Asp Ser Arg Gln Ala  Pro Lys Asn Met Pro  Gln Asp Ala 
    1295                 1300                 1305             


Asp Ala  Asn Gly Ala Tyr His  Ile Gly Leu Lys Gly  Leu Met Leu 
    1310                 1315                 1320             


Leu Gly  Arg Ile Lys Asn Asn  Gln Glu Gly Lys Lys  Leu Asn Leu 
    1325                 1330                 1335             


Val Ile  Lys Asn Glu Glu Tyr  Phe Glu Phe Val Gln  Asn Arg Asn 
    1340                 1345                 1350             


Asn Pro  Lys Lys Lys Arg Lys  Val Ser Gly Gly Ser  Ser Gly Gly 
    1355                 1360                 1365             


Ser Pro  Lys Lys Lys Arg Lys  Val Tyr Pro Tyr Asp  Val Pro Asp 
    1370                 1375                 1380             


Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala Tyr  Pro Tyr Asp 
    1385                 1390                 1395             


Val Pro  Asp Tyr Ala 
    1400             


<210>  63
<211>  1382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Thr 
            20                  25                  30          


Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr Leu Arg 
        35                  40                  45              


Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln Glu Gln 
    50                  55                  60                  


Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys Glu Leu 
65                  70                  75                  80  


Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln Cys Leu 
                85                  90                  95      


Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile Asp Ser 
            100                 105                 110         


Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile Glu Glu 
        115                 120                 125             


Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly Arg Thr 
    130                 135                 140                 


Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile Tyr Lys 
145                 150                 155                 160 


Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys Gln Leu 
                165                 170                 175     


Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg Ser Phe 
            180                 185                 190         


Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg Lys Asn 
        195                 200                 205             


Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg Ile Val 
    210                 215                 220                 


Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe Thr Arg 
225                 230                 235                 240 


Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn Val Lys 
                245                 250                 255     


Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val Phe Ser 
            260                 265                 270         


Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp Leu Tyr 
        275                 280                 285             


Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu Lys Ile 
    290                 295                 300                 


Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn Asp Glu 
305                 310                 315                 320 


Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro Leu Phe 
                325                 330                 335     


Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu Glu Glu 
            340                 345                 350         


Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr Lys Thr 
        355                 360                 365             


Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu Phe Asn 
    370                 375                 380                 


Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His Lys Lys 
385                 390                 395                 400 


Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr Leu Arg 
                405                 410                 415     


Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys Ile Thr 
            420                 425                 430         


Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu Asp Ile 
        435                 440                 445             


Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser Glu Ala 
    450                 455                 460                 


Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala Ala Leu 
465                 470                 475                 480 


Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys Glu Ile 
                485                 490                 495     


Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu Leu Asp 
            500                 505                 510         


Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe Ser Ala 
        515                 520                 525             


Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser Phe Tyr 
    530                 535                 540                 


Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val Glu Lys 
545                 550                 555                 560 


Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp Asp Val 
                565                 570                 575     


Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn Gly Leu 
            580                 585                 590         


Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys Ala Leu 
        595                 600                 605             


Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys Met Tyr 
    610                 615                 620                 


Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys Ser Thr 
625                 630                 635                 640 


Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr Pro Ile 
                645                 650                 655     


Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys Glu Ile 
            660                 665                 670         


Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln Thr Ala 
        675                 680                 685             


Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala Leu Cys 
    690                 695                 700                 


Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr Lys Thr 
705                 710                 715                 720 


Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr Lys Asp 
                725                 730                 735     


Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His Ile Ser 
            740                 745                 750         


Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu Thr Gly 
        755                 760                 765             


Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys Gly His 
    770                 775                 780                 


His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu Phe Ser 
785                 790                 795                 800 


Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln Ala Glu 
                805                 810                 815     


Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His Arg Leu 
            820                 825                 830         


Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr Pro Ile 
        835                 840                 845             


Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His Arg Leu 
    850                 855                 860                 


Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn Val Ile 
865                 870                 875                 880 


Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe Thr Ser 
                885                 890                 895     


Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln Ala Ala 
            900                 905                 910         


Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu Lys Glu 
        915                 920                 925             


His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu 
    930                 935                 940                 


Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu Gln Arg 
945                 950                 955                 960 


Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu Asp Asn 
                965                 970                 975     


Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val Val Gly 
            980                 985                 990         


Thr Ile Lys Asp Leu Lys Gln Gly  Tyr Leu Ser Gln Val  Ile His Glu 
        995                 1000                 1005             


Ile Val  Asp Leu Met Ile His  Tyr Gln Ala Val Val  Val Leu Glu 
    1010                 1015                 1020             


Asn Leu  Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
    1025                 1030                 1035             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1040                 1045                 1050             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1055                 1060                 1065             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1070                 1075                 1080             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1085                 1090                 1095             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1100                 1105                 1110             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1115                 1120                 1125             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1130                 1135                 1140             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1145                 1150                 1155             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1160                 1165                 1170             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1175                 1180                 1185             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1190                 1195                 1200             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1205                 1210                 1215             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1220                 1225                 1230             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1235                 1240                 1245             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1250                 1255                 1260             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1265                 1270                 1275             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1280                 1285                 1290             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1295                 1300                 1305             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1310                 1315                 1320             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn Lys 
    1325                 1330                 1335             


Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys 
    1340                 1345                 1350             


Gly Ser  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala Tyr  Pro Tyr Asp 
    1355                 1360                 1365             


Val Pro  Asp Tyr Ala Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala 
    1370                 1375                 1380         


<210>  64
<211>  1346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Thr 
            20                  25                  30          


Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr Leu Arg 
        35                  40                  45              


Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln Glu Gln 
    50                  55                  60                  


Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys Glu Leu 
65                  70                  75                  80  


Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln Cys Leu 
                85                  90                  95      


Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile Asp Ser 
            100                 105                 110         


Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile Glu Glu 
        115                 120                 125             


Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly Arg Thr 
    130                 135                 140                 


Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile Tyr Lys 
145                 150                 155                 160 


Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys Gln Leu 
                165                 170                 175     


Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg Ser Phe 
            180                 185                 190         


Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg Lys Asn 
        195                 200                 205             


Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg Ile Val 
    210                 215                 220                 


Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe Thr Arg 
225                 230                 235                 240 


Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn Val Lys 
                245                 250                 255     


Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val Phe Ser 
            260                 265                 270         


Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp Leu Tyr 
        275                 280                 285             


Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu Lys Ile 
    290                 295                 300                 


Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn Asp Glu 
305                 310                 315                 320 


Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro Leu Phe 
                325                 330                 335     


Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu Glu Glu 
            340                 345                 350         


Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr Lys Thr 
        355                 360                 365             


Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu Phe Asn 
    370                 375                 380                 


Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His Lys Lys 
385                 390                 395                 400 


Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr Leu Arg 
                405                 410                 415     


Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys Ile Thr 
            420                 425                 430         


Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu Asp Ile 
        435                 440                 445             


Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser Glu Ala 
    450                 455                 460                 


Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala Ala Leu 
465                 470                 475                 480 


Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys Glu Ile 
                485                 490                 495     


Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu Leu Asp 
            500                 505                 510         


Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe Ser Ala 
        515                 520                 525             


Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser Phe Tyr 
    530                 535                 540                 


Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val Glu Lys 
545                 550                 555                 560 


Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp Asp Val 
                565                 570                 575     


Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn Gly Leu 
            580                 585                 590         


Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys Ala Leu 
        595                 600                 605             


Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys Met Tyr 
    610                 615                 620                 


Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys Ser Thr 
625                 630                 635                 640 


Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr Pro Ile 
                645                 650                 655     


Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys Glu Ile 
            660                 665                 670         


Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln Thr Ala 
        675                 680                 685             


Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala Leu Cys 
    690                 695                 700                 


Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr Lys Thr 
705                 710                 715                 720 


Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr Lys Asp 
                725                 730                 735     


Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His Ile Ser 
            740                 745                 750         


Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu Thr Gly 
        755                 760                 765             


Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys Gly His 
    770                 775                 780                 


His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu Phe Ser 
785                 790                 795                 800 


Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln Ala Glu 
                805                 810                 815     


Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His Arg Leu 
            820                 825                 830         


Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr Pro Ile 
        835                 840                 845             


Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His Arg Leu 
    850                 855                 860                 


Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn Val Ile 
865                 870                 875                 880 


Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe Thr Ser 
                885                 890                 895     


Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln Ala Ala 
            900                 905                 910         


Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu Lys Glu 
        915                 920                 925             


His Pro Glu Thr Pro Ile Ile Gly Ile Ala Arg Gly Glu Arg Asn Leu 
    930                 935                 940                 


Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu Gln Arg 
945                 950                 955                 960 


Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu Asp Asn 
                965                 970                 975     


Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val Val Gly 
            980                 985                 990         


Thr Ile Lys Asp Leu Lys Gln Gly  Tyr Leu Ser Gln Val  Ile His Glu 
        995                 1000                 1005             


Ile Val  Asp Leu Met Ile His  Tyr Gln Ala Val Val  Val Leu Ala 
    1010                 1015                 1020             


Asn Leu  Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
    1025                 1030                 1035             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1040                 1045                 1050             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1055                 1060                 1065             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1070                 1075                 1080             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1085                 1090                 1095             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1100                 1105                 1110             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1115                 1120                 1125             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1130                 1135                 1140             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1145                 1150                 1155             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1160                 1165                 1170             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1175                 1180                 1185             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1190                 1195                 1200             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1205                 1210                 1215             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1220                 1225                 1230             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1235                 1240                 1245             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1250                 1255                 1260             


Glu Ala  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1265                 1270                 1275             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1280                 1285                 1290             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1295                 1300                 1305             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1310                 1315                 1320             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn Gly 
    1325                 1330                 1335             


Ser Pro  Lys Lys Lys Arg Lys  Val 
    1340                 1345     


<210>  65
<211>  1417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Pro 
            20                  25                  30          


Lys Lys Lys Arg Lys Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Ser Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser 
65                  70                  75                  80  


Leu Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu 
                85                  90                  95      


Glu Asn Ile Lys Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala 
            100                 105                 110         


Lys Asp Tyr Lys Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe 
        115                 120                 125             


Phe Ile Glu Glu Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu 
    130                 135                 140                 


Gln Asn Tyr Ser Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp 
145                 150                 155                 160 


Asn Leu Gln Lys Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln 
                165                 170                 175     


Ile Ser Glu Tyr Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn 
            180                 185                 190         


Gln Asn Leu Ile Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu 
        195                 200                 205             


Trp Leu Lys Gln Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn 
    210                 215                 220                 


Ser Asp Ile Thr Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe 
225                 230                 235                 240 


Lys Gly Trp Thr Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn 
                245                 250                 255     


Val Tyr Ser Ser Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val 
            260                 265                 270         


Asp Asp Asn Leu Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser 
        275                 280                 285             


Leu Lys Asp Lys Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys 
    290                 295                 300                 


Asp Leu Ala Glu Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu 
305                 310                 315                 320 


Val Asn Gln Arg Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn 
                325                 330                 335     


Phe Asn Asn Tyr Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile 
            340                 345                 350         


Ile Gly Gly Lys Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile 
        355                 360                 365             


Asn Glu Tyr Ile Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu 
    370                 375                 380                 


Lys Lys Tyr Lys Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr 
385                 390                 395                 400 


Glu Ser Lys Ser Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val 
                405                 410                 415     


Val Thr Thr Met Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr 
            420                 425                 430         


Val Glu Glu Lys Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp 
        435                 440                 445             


Leu Lys Ala Gln Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp 
    450                 455                 460                 


Lys Ser Leu Thr Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val 
465                 470                 475                 480 


Ile Gly Thr Ala Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys 
                485                 490                 495     


Asn Leu Asp Asn Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys 
            500                 505                 510         


Thr Glu Lys Ala Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu 
        515                 520                 525             


Glu Glu Phe Asn Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu 
    530                 535                 540                 


Glu Ile Leu Ala Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile 
545                 550                 555                 560 


Ala Gln Asn Lys Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn 
                565                 570                 575     


Gln Gly Lys Lys Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys 
            580                 585                 590         


Ala Ile Lys Asp Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu 
        595                 600                 605             


Lys Ile Phe His Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp 
    610                 615                 620                 


Lys Asp Glu His Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu 
625                 630                 635                 640 


Ala Asn Ile Val Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln 
                645                 650                 655     


Lys Pro Tyr Ser Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr 
            660                 665                 670         


Leu Ala Asn Gly Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile 
        675                 680                 685             


Leu Phe Ile Lys Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys 
    690                 695                 700                 


Asn Asn Lys Ile Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu 
705                 710                 715                 720 


Gly Tyr Lys Lys Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met 
                725                 730                 735     


Leu Pro Lys Val Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro 
            740                 745                 750         


Ser Glu Asp Ile Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn 
        755                 760                 765             


Gly Ser Pro Gln Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp 
    770                 775                 780                 


Cys Arg Lys Phe Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro 
785                 790                 795                 800 


Glu Trp Lys Asp Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn 
                805                 810                 815     


Ser Ile Asp Glu Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu 
            820                 825                 830         


Thr Phe Glu Asn Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln 
        835                 840                 845             


Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr 
    850                 855                 860                 


Ser Lys Gly Arg Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe 
865                 870                 875                 880 


Asp Glu Arg Asn Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala 
                885                 890                 895     


Glu Leu Phe Tyr Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro 
            900                 905                 910         


Ala Lys Glu Ala Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu 
        915                 920                 925             


Ser Val Phe Glu Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp 
    930                 935                 940                 


Lys Phe Phe Phe His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly 
945                 950                 955                 960 


Ala Asn Lys Phe Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala 
                965                 970                 975     


Asn Asp Val His Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala 
            980                 985                 990         


Tyr Tyr Thr Leu Val Asp Gly Lys  Gly Asn Ile Ile Lys  Gln Asp Thr 
        995                 1000                 1005             


Phe Asn  Ile Ile Gly Asn Asp  Arg Met Lys Thr Asn  Tyr His Asp 
    1010                 1015                 1020             


Lys Leu  Ala Ala Ile Glu Lys  Asp Arg Asp Ser Ala  Arg Lys Asp 
    1025                 1030                 1035             


Trp Lys  Lys Ile Asn Asn Ile  Lys Glu Met Lys Glu  Gly Tyr Leu 
    1040                 1045                 1050             


Ser Gln  Val Val His Glu Ile  Ala Lys Leu Val Ile  Glu Tyr Asn 
    1055                 1060                 1065             


Ala Ile  Val Val Phe Glu Asp  Leu Asn Phe Gly Phe  Lys Arg Gly 
    1070                 1075                 1080             


Arg Phe  Lys Val Glu Lys Gln  Val Tyr Gln Lys Leu  Glu Lys Met 
    1085                 1090                 1095             


Leu Ile  Glu Lys Leu Asn Tyr  Leu Val Phe Lys Asp  Asn Glu Phe 
    1100                 1105                 1110             


Asp Lys  Thr Gly Gly Val Leu  Arg Ala Tyr Gln Leu  Thr Ala Pro 
    1115                 1120                 1125             


Phe Glu  Thr Phe Lys Lys Met  Gly Lys Gln Thr Gly  Ile Ile Tyr 
    1130                 1135                 1140             


Tyr Val  Pro Ala Gly Phe Thr  Ser Lys Ile Cys Pro  Val Thr Gly 
    1145                 1150                 1155             


Phe Val  Asn Gln Leu Tyr Pro  Lys Tyr Glu Ser Val  Ser Lys Ser 
    1160                 1165                 1170             


Gln Glu  Phe Phe Ser Lys Phe  Asp Lys Ile Cys Tyr  Asn Leu Asp 
    1175                 1180                 1185             


Lys Gly  Tyr Phe Glu Phe Ser  Phe Asp Tyr Lys Asn  Phe Gly Asp 
    1190                 1195                 1200             


Lys Ala  Ala Lys Gly Lys Trp  Thr Ile Ala Ser Phe  Gly Ser Arg 
    1205                 1210                 1215             


Leu Ile  Asn Phe Arg Asn Ser  Asp Lys Asn His Asn  Trp Asp Thr 
    1220                 1225                 1230             


Arg Glu  Val Tyr Pro Thr Lys  Glu Leu Glu Lys Leu  Leu Lys Asp 
    1235                 1240                 1245             


Tyr Ser  Ile Glu Tyr Gly His  Gly Glu Cys Ile Lys  Ala Ala Ile 
    1250                 1255                 1260             


Cys Gly  Glu Ser Asp Lys Lys  Phe Phe Ala Lys Leu  Thr Ser Val 
    1265                 1270                 1275             


Leu Asn  Thr Ile Leu Gln Met  Arg Asn Ser Lys Thr  Gly Thr Glu 
    1280                 1285                 1290             


Leu Asp  Tyr Leu Ile Ser Pro  Val Ala Asp Val Asn  Gly Asn Phe 
    1295                 1300                 1305             


Phe Asp  Ser Arg Gln Ala Pro  Lys Asn Met Pro Gln  Asp Ala Asp 
    1310                 1315                 1320             


Ala Asn  Gly Ala Tyr His Ile  Gly Leu Lys Gly Leu  Met Leu Leu 
    1325                 1330                 1335             


Gly Arg  Ile Lys Asn Asn Gln  Glu Gly Lys Lys Leu  Asn Leu Val 
    1340                 1345                 1350             


Ile Lys  Asn Glu Glu Tyr Phe  Glu Phe Val Gln Asn  Arg Asn Asn 
    1355                 1360                 1365             


Pro Lys  Lys Lys Arg Lys Val  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1370                 1375                 1380             


Pro Lys  Lys Lys Arg Lys Val  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1385                 1390                 1395             


Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala Tyr Pro  Tyr Asp Val 
    1400                 1405                 1410             


Pro Asp  Tyr Ala 
    1415         


<210>  66
<211>  1287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntheti

<400>  66

Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Met Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu 
        35                  40                  45              


Ser Lys Thr Val Arg Phe Glu Leu Lys Pro Ile Gly Arg Thr Leu Glu 
    50                  55                  60                  


His Ile His Ala Lys Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp 
65                  70                  75                  80  


Met Tyr Gln Lys Val Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe 
                85                  90                  95      


Ile Ala Asp Met Met Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe 
            100                 105                 110         


Tyr Asp Val Tyr Leu Lys Phe Arg Lys Asn Pro Lys Asp Asp Gly Leu 
        115                 120                 125             


Gln Lys Gln Leu Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ser Val 
    130                 135                 140                 


Lys Pro Ile Gly Ser Gly Gly Lys Tyr Lys Thr Gly Tyr Asp Arg Leu 
145                 150                 155                 160 


Phe Gly Ala Lys Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala 
                165                 170                 175     


Lys Phe Val Ile Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His 
            180                 185                 190         


Leu Ala His Phe Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp 
        195                 200                 205             


Asn Arg Lys Asn Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala 
    210                 215                 220                 


Tyr Arg Leu Ile His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln 
225                 230                 235                 240 


Ile Leu Thr Thr Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile 
                245                 250                 255     


Ile Asn Glu Leu Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His 
            260                 265                 270         


Leu Asp Gly Tyr His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr 
        275                 280                 285             


Asn Arg Ile Ile Gly Glu Val Asn Gly Tyr Thr Asn Lys His Asn Gln 
    290                 295                 300                 


Ile Cys His Lys Ser Glu Arg Ile Ala Lys Leu Arg Pro Leu His Lys 
305                 310                 315                 320 


Gln Ile Leu Ser Asp Gly Met Gly Val Ser Phe Leu Pro Ser Lys Phe 
                325                 330                 335     


Ala Asp Asp Ser Glu Met Cys Gln Ala Val Asn Glu Phe Tyr Arg His 
            340                 345                 350         


Tyr Thr Asp Val Phe Ala Lys Val Gln Ser Leu Phe Asp Gly Phe Asp 
        355                 360                 365             


Asp His Gln Lys Asp Gly Ile Tyr Val Glu His Lys Asn Leu Asn Glu 
    370                 375                 380                 


Leu Ser Lys Gln Ala Phe Gly Asp Phe Ala Leu Leu Gly Arg Val Leu 
385                 390                 395                 400 


Asp Gly Tyr Tyr Val Asp Val Val Asn Pro Glu Phe Asn Glu Arg Phe 
                405                 410                 415     


Ala Lys Ala Lys Thr Asp Asn Ala Lys Ala Lys Leu Thr Lys Glu Lys 
            420                 425                 430         


Asp Lys Phe Ile Lys Gly Val His Ser Leu Ala Ser Leu Glu Gln Ala 
        435                 440                 445             


Ile Glu His His Thr Ala Arg His Asp Asp Glu Ser Val Gln Ala Gly 
    450                 455                 460                 


Lys Leu Gly Gln Tyr Phe Lys His Gly Leu Ala Gly Val Asp Asn Pro 
465                 470                 475                 480 


Ile Gln Lys Ile His Asn Asn His Ser Thr Ile Lys Gly Phe Leu Glu 
                485                 490                 495     


Arg Glu Arg Pro Ala Gly Glu Arg Ala Leu Pro Lys Ile Lys Ser Gly 
            500                 505                 510         


Lys Asn Pro Glu Met Thr Gln Leu Arg Gln Leu Lys Glu Leu Leu Asp 
        515                 520                 525             


Asn Ala Leu Asn Val Ala His Phe Ala Lys Leu Leu Thr Thr Lys Thr 
    530                 535                 540                 


Thr Leu Asp Asn Gln Asp Gly Asn Phe Tyr Gly Glu Phe Gly Val Leu 
545                 550                 555                 560 


Tyr Asp Glu Leu Ala Lys Ile Pro Thr Leu Tyr Asn Lys Val Arg Asp 
                565                 570                 575     


Tyr Leu Ser Gln Lys Pro Phe Ser Thr Glu Lys Tyr Lys Leu Asn Phe 
            580                 585                 590         


Gly Asn Pro Thr Leu Leu Asn Gly Trp Asp Leu Asn Lys Glu Lys Asp 
        595                 600                 605             


Asn Phe Gly Val Ile Leu Gln Lys Asp Gly Cys Tyr Tyr Leu Ala Leu 
    610                 615                 620                 


Leu Asp Lys Ala His Lys Lys Val Phe Asp Asn Ala Pro Asn Thr Gly 
625                 630                 635                 640 


Lys Asn Val Tyr Gln Lys Met Val Tyr Lys Leu Leu Pro Gly Pro Asn 
                645                 650                 655     


Lys Met Leu Pro Lys Val Phe Phe Ala Lys Ser Asn Leu Asp Tyr Tyr 
            660                 665                 670         


Asn Pro Ser Ala Glu Leu Leu Asp Lys Tyr Ala Lys Gly Thr His Lys 
        675                 680                 685             


Lys Gly Asp Asn Phe Asn Leu Lys Asp Cys His Ala Leu Ile Asp Phe 
    690                 695                 700                 


Phe Lys Ala Gly Ile Asn Lys His Pro Glu Trp Gln His Phe Gly Phe 
705                 710                 715                 720 


Lys Phe Ser Pro Thr Ser Ser Tyr Arg Asp Leu Ser Asp Phe Tyr Arg 
                725                 730                 735     


Glu Val Glu Pro Gln Gly Tyr Gln Val Lys Phe Val Asp Ile Asn Ala 
            740                 745                 750         


Asp Tyr Ile Asp Glu Leu Val Glu Gln Gly Lys Leu Tyr Leu Phe Gln 
        755                 760                 765             


Ile Tyr Asn Lys Asp Phe Ser Pro Lys Ala His Gly Lys Pro Asn Leu 
    770                 775                 780                 


His Thr Leu Tyr Phe Lys Ala Leu Phe Ser Glu Asp Asn Leu Ala Asp 
785                 790                 795                 800 


Pro Ile Tyr Lys Leu Asn Gly Glu Ala Gln Ile Phe Tyr Arg Lys Ala 
                805                 810                 815     


Ser Leu Asp Met Asn Glu Thr Thr Ile His Arg Ala Gly Glu Val Leu 
            820                 825                 830         


Glu Asn Lys Asn Pro Asp Asn Pro Lys Lys Arg Gln Phe Val Tyr Asp 
        835                 840                 845             


Ile Ile Lys Asp Lys Arg Tyr Thr Gln Asp Lys Phe Met Leu His Val 
    850                 855                 860                 


Pro Ile Thr Met Asn Phe Gly Val Gln Gly Met Thr Ile Lys Glu Phe 
865                 870                 875                 880 


Asn Lys Lys Val Asn Gln Ser Ile Gln Gln Tyr Asp Glu Val Asn Val 
                885                 890                 895     


Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Thr Val Ile 
            900                 905                 910         


Asn Ser Lys Gly Glu Ile Leu Glu Gln Arg Ser Leu Asn Asp Ile Thr 
        915                 920                 925             


Thr Ala Ser Ala Asn Gly Thr Gln Val Thr Thr Pro Tyr His Lys Ile 
    930                 935                 940                 


Leu Asp Lys Arg Glu Ile Glu Arg Leu Asn Ala Arg Val Gly Trp Gly 
945                 950                 955                 960 


Glu Ile Glu Thr Ile Lys Glu Leu Lys Ser Gly Tyr Leu Ser His Val 
                965                 970                 975     


Val His Gln Ile Asn Gln Leu Met Leu Lys Tyr Asn Ala Ile Val Val 
            980                 985                 990         


Leu Glu Asp Leu Asn Phe Gly Phe  Lys Arg Gly Arg Phe  Lys Val Glu 
        995                 1000                 1005             


Lys Gln  Ile Tyr Gln Asn Phe  Glu Asn Ala Leu Ile  Lys Lys Leu 
    1010                 1015                 1020             


Asn His  Leu Val Leu Lys Asp  Lys Ala Asp Asp Glu  Ile Gly Ser 
    1025                 1030                 1035             


Tyr Lys  Asn Ala Leu Gln Leu  Thr Asn Asn Phe Thr  Asp Leu Lys 
    1040                 1045                 1050             


Ser Ile  Gly Lys Gln Thr Gly  Phe Leu Phe Tyr Val  Pro Ala Trp 
    1055                 1060                 1065             


Asn Thr  Ser Lys Ile Asp Pro  Glu Thr Gly Phe Val  Asp Leu Leu 
    1070                 1075                 1080             


Lys Pro  Arg Tyr Glu Asn Ile  Ala Gln Ser Gln Ala  Phe Phe Gly 
    1085                 1090                 1095             


Lys Phe  Asp Lys Ile Cys Tyr  Asn Thr Asp Lys Gly  Tyr Phe Glu 
    1100                 1105                 1110             


Phe His  Ile Asp Tyr Ala Lys  Phe Thr Asp Lys Ala  Lys Asn Ser 
    1115                 1120                 1125             


Arg Gln  Lys Trp Ala Ile Cys  Ser His Gly Asp Lys  Arg Tyr Val 
    1130                 1135                 1140             


Tyr Asp  Lys Thr Ala Asn Gln  Asn Lys Gly Ala Ala  Lys Gly Ile 
    1145                 1150                 1155             


Asn Val  Asn Asp Glu Leu Lys  Ser Leu Phe Ala Arg  Tyr His Ile 
    1160                 1165                 1170             


Asn Asp  Lys Gln Pro Asn Leu  Val Met Asp Ile Cys  Gln Asn Asn 
    1175                 1180                 1185             


Asp Lys  Glu Phe His Lys Ser  Leu Met Cys Leu Leu  Lys Thr Leu 
    1190                 1195                 1200             


Leu Ala  Leu Arg Tyr Ser Asn  Ala Ser Ser Asp Glu  Asp Phe Ile 
    1205                 1210                 1215             


Leu Ser  Pro Val Ala Asn Asp  Glu Gly Val Phe Phe  Asn Ser Ala 
    1220                 1225                 1230             


Leu Ala  Asp Asp Thr Gln Pro  Gln Asn Ala Asp Ala  Asn Gly Ala 
    1235                 1240                 1245             


Tyr His  Ile Ala Leu Lys Gly  Leu Trp Leu Leu Asn  Glu Leu Lys 
    1250                 1255                 1260             


Asn Ser  Asp Asp Leu Asn Lys  Val Lys Leu Ala Ile  Asp Asn Gln 
    1265                 1270                 1275             


Thr Trp  Leu Asn Phe Ala Gln  Asn Arg 
    1280                 1285         


<210>  67
<211>  1388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67

Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln 
        35                  40                  45              


Val Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu 
    50                  55                  60                  


Lys His Ile Gln Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn 
65                  70                  75                  80  


Asp His Tyr Lys Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr 
                85                  90                  95      


Tyr Ala Asp Gln Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu 
            100                 105                 110         


Ser Ala Ala Ile Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg 
        115                 120                 125             


Asn Ala Leu Ile Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp 
    130                 135                 140                 


Tyr Phe Ile Gly Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg 
145                 150                 155                 160 


His Ala Glu Ile Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly 
                165                 170                 175     


Lys Val Leu Lys Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn 
            180                 185                 190         


Ala Leu Leu Arg Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe 
        195                 200                 205             


Tyr Glu Asn Arg Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala 
    210                 215                 220                 


Ile Pro His Arg Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn 
225                 230                 235                 240 


Cys His Ile Phe Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu 
                245                 250                 255     


His Phe Glu Asn Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser 
            260                 265                 270         


Ile Glu Glu Val Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln 
        275                 280                 285             


Thr Gln Ile Asp Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu 
    290                 295                 300                 


Ala Gly Thr Glu Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala 
305                 310                 315                 320 


Ile Gln Lys Asn Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His 
                325                 330                 335     


Arg Phe Ile Pro Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu 
            340                 345                 350         


Ser Phe Ile Leu Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser 
        355                 360                 365             


Phe Cys Lys Tyr Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr 
    370                 375                 380                 


Ala Glu Ala Leu Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile 
385                 390                 395                 400 


Phe Ile Ser His Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp 
                405                 410                 415     


His Trp Asp Thr Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu 
            420                 425                 430         


Leu Thr Gly Lys Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser 
        435                 440                 445             


Leu Lys His Glu Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly 
    450                 455                 460                 


Lys Glu Leu Ser Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser 
465                 470                 475                 480 


His Ala His Ala Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys 
                485                 490                 495     


Gln Glu Glu Lys Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly 
            500                 505                 510         


Leu Tyr His Leu Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val 
        515                 520                 525             


Asp Pro Glu Phe Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu 
    530                 535                 540                 


Pro Ser Leu Ser Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys 
545                 550                 555                 560 


Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu 
                565                 570                 575     


Ala Ser Gly Trp Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu 
            580                 585                 590         


Phe Val Lys Asn Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys 
        595                 600                 605             


Gly Arg Tyr Lys Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu 
    610                 615                 620                 


Gly Phe Asp Lys Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met 
625                 630                 635                 640 


Ile Pro Lys Cys Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln 
                645                 650                 655     


Thr His Thr Thr Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu 
            660                 665                 670         


Glu Ile Thr Lys Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro 
        675                 680                 685             


Lys Lys Phe Gln Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly 
    690                 695                 700                 


Tyr Arg Glu Ala Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu 
705                 710                 715                 720 


Ser Lys Tyr Thr Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro 
                725                 730                 735     


Ser Ser Gln Tyr Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro 
            740                 745                 750         


Leu Leu Tyr His Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met 
        755                 760                 765             


Asp Ala Val Glu Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
    770                 775                 780                 


Asp Phe Ala Lys Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr 
785                 790                 795                 800 


Trp Thr Gly Leu Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys 
                805                 810                 815     


Leu Asn Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys 
            820                 825                 830         


Arg Met Ala His Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys 
        835                 840                 845             


Asp Gln Lys Thr Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp 
    850                 855                 860                 


Tyr Val Asn His Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala 
865                 870                 875                 880 


Leu Leu Pro Asn Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys 
                885                 890                 895     


Asp Arg Arg Phe Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr 
            900                 905                 910         


Leu Asn Tyr Gln Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val 
        915                 920                 925             


Asn Ala Tyr Leu Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp 
    930                 935                 940                 


Arg Gly Glu Arg Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly 
945                 950                 955                 960 


Lys Ile Leu Glu Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr 
                965                 970                 975     


Gln Lys Lys Leu Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln 
            980                 985                 990         


Ala Trp Ser Val Val Gly Thr Ile  Lys Asp Leu Lys Gln  Gly Tyr Leu 
        995                 1000                 1005             


Ser Gln  Val Ile His Glu Ile  Val Asp Leu Met Ile  His Tyr Gln 
    1010                 1015                 1020             


Ala Val  Val Val Leu Glu Asn  Leu Asn Phe Gly Phe  Lys Ser Lys 
    1025                 1030                 1035             


Arg Thr  Gly Ile Ala Glu Lys  Ala Val Tyr Gln Gln  Phe Glu Lys 
    1040                 1045                 1050             


Met Leu  Ile Asp Lys Leu Asn  Cys Leu Val Leu Lys  Asp Tyr Pro 
    1055                 1060                 1065             


Ala Glu  Lys Val Gly Gly Val  Leu Asn Pro Tyr Gln  Leu Thr Asp 
    1070                 1075                 1080             


Gln Phe  Thr Ser Phe Ala Lys  Met Gly Thr Gln Ser  Gly Phe Leu 
    1085                 1090                 1095             


Phe Tyr  Val Pro Ala Pro Tyr  Thr Ser Lys Ile Asp  Pro Leu Thr 
    1100                 1105                 1110             


Gly Phe  Val Asp Pro Phe Val  Trp Lys Thr Ile Lys  Asn His Glu 
    1115                 1120                 1125             


Ser Arg  Lys His Phe Leu Glu  Gly Phe Asp Phe Leu  His Tyr Asp 
    1130                 1135                 1140             


Val Lys  Thr Gly Asp Phe Ile  Leu His Phe Lys Met  Asn Arg Asn 
    1145                 1150                 1155             


Leu Ser  Phe Gln Arg Gly Leu  Pro Gly Phe Met Pro  Ala Trp Asp 
    1160                 1165                 1170             


Ile Val  Phe Glu Lys Asn Glu  Thr Gln Phe Asp Ala  Lys Gly Thr 
    1175                 1180                 1185             


Pro Phe  Ile Ala Gly Lys Arg  Ile Val Pro Val Ile  Glu Asn His 
    1190                 1195                 1200             


Arg Phe  Thr Gly Arg Tyr Arg  Asp Leu Tyr Pro Ala  Asn Glu Leu 
    1205                 1210                 1215             


Ile Ala  Leu Leu Glu Glu Lys  Gly Ile Val Phe Arg  Asp Gly Ser 
    1220                 1225                 1230             


Asn Ile  Leu Pro Lys Leu Leu  Glu Asn Asp Asp Ser  His Ala Ile 
    1235                 1240                 1245             


Asp Thr  Met Val Ala Leu Ile  Arg Ser Val Leu Gln  Met Arg Asn 
    1250                 1255                 1260             


Ser Asn  Ala Ala Thr Gly Glu  Asp Tyr Ile Asn Ser  Pro Val Arg 
    1265                 1270                 1275             


Asp Leu  Asn Gly Val Cys Phe  Asp Ser Arg Phe Gln  Asn Pro Glu 
    1280                 1285                 1290             


Trp Pro  Met Asp Ala Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu 
    1295                 1300                 1305             


Lys Gly  Gln Leu Leu Leu Asn  His Leu Lys Glu Ser  Lys Asp Leu 
    1310                 1315                 1320             


Lys Leu  Gln Asn Gly Ile Ser  Asn Gln Asp Trp Leu  Ala Tyr Ile 
    1325                 1330                 1335             


Gln Glu  Leu Arg Asn Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly 
    1340                 1345                 1350             


Gln Ala  Lys Lys Lys Lys Gly  Ser Tyr Pro Tyr Asp  Val Pro Asp 
    1355                 1360                 1365             


Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala Tyr  Pro Tyr Asp 
    1370                 1375                 1380             


Val Pro  Asp Tyr Ala 
    1385             


<210>  68
<211>  1352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntheti

<400>  68

Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln 
        35                  40                  45              


Val Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu 
    50                  55                  60                  


Lys His Ile Gln Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn 
65                  70                  75                  80  


Asp His Tyr Lys Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr 
                85                  90                  95      


Tyr Ala Asp Gln Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu 
            100                 105                 110         


Ser Ala Ala Ile Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg 
        115                 120                 125             


Asn Ala Leu Ile Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp 
    130                 135                 140                 


Tyr Phe Ile Gly Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg 
145                 150                 155                 160 


His Ala Glu Ile Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly 
                165                 170                 175     


Lys Val Leu Lys Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn 
            180                 185                 190         


Ala Leu Leu Arg Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe 
        195                 200                 205             


Tyr Glu Asn Arg Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala 
    210                 215                 220                 


Ile Pro His Arg Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn 
225                 230                 235                 240 


Cys His Ile Phe Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu 
                245                 250                 255     


His Phe Glu Asn Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser 
            260                 265                 270         


Ile Glu Glu Val Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln 
        275                 280                 285             


Thr Gln Ile Asp Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu 
    290                 295                 300                 


Ala Gly Thr Glu Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala 
305                 310                 315                 320 


Ile Gln Lys Asn Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His 
                325                 330                 335     


Arg Phe Ile Pro Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu 
            340                 345                 350         


Ser Phe Ile Leu Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser 
        355                 360                 365             


Phe Cys Lys Tyr Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr 
    370                 375                 380                 


Ala Glu Ala Leu Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile 
385                 390                 395                 400 


Phe Ile Ser His Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp 
                405                 410                 415     


His Trp Asp Thr Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu 
            420                 425                 430         


Leu Thr Gly Lys Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser 
        435                 440                 445             


Leu Lys His Glu Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly 
    450                 455                 460                 


Lys Glu Leu Ser Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser 
465                 470                 475                 480 


His Ala His Ala Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys 
                485                 490                 495     


Gln Glu Glu Lys Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly 
            500                 505                 510         


Leu Tyr His Leu Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val 
        515                 520                 525             


Asp Pro Glu Phe Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu 
    530                 535                 540                 


Pro Ser Leu Ser Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys 
545                 550                 555                 560 


Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu 
                565                 570                 575     


Ala Ser Gly Trp Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu 
            580                 585                 590         


Phe Val Lys Asn Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys 
        595                 600                 605             


Gly Arg Tyr Lys Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu 
    610                 615                 620                 


Gly Phe Asp Lys Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met 
625                 630                 635                 640 


Ile Pro Lys Cys Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln 
                645                 650                 655     


Thr His Thr Thr Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu 
            660                 665                 670         


Glu Ile Thr Lys Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro 
        675                 680                 685             


Lys Lys Phe Gln Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly 
    690                 695                 700                 


Tyr Arg Glu Ala Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu 
705                 710                 715                 720 


Ser Lys Tyr Thr Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro 
                725                 730                 735     


Ser Ser Gln Tyr Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro 
            740                 745                 750         


Leu Leu Tyr His Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met 
        755                 760                 765             


Asp Ala Val Glu Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
    770                 775                 780                 


Asp Phe Ala Lys Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr 
785                 790                 795                 800 


Trp Thr Gly Leu Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys 
                805                 810                 815     


Leu Asn Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys 
            820                 825                 830         


Arg Met Ala His Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys 
        835                 840                 845             


Asp Gln Lys Thr Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp 
    850                 855                 860                 


Tyr Val Asn His Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala 
865                 870                 875                 880 


Leu Leu Pro Asn Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys 
                885                 890                 895     


Asp Arg Arg Phe Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr 
            900                 905                 910         


Leu Asn Tyr Gln Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val 
        915                 920                 925             


Asn Ala Tyr Leu Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Ala 
    930                 935                 940                 


Arg Gly Glu Arg Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly 
945                 950                 955                 960 


Lys Ile Leu Glu Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr 
                965                 970                 975     


Gln Lys Lys Leu Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln 
            980                 985                 990         


Ala Trp Ser Val Val Gly Thr Ile  Lys Asp Leu Lys Gln  Gly Tyr Leu 
        995                 1000                 1005             


Ser Gln  Val Ile His Glu Ile  Val Asp Leu Met Ile  His Tyr Gln 
    1010                 1015                 1020             


Ala Val  Val Val Leu Ala Asn  Leu Asn Phe Gly Phe  Lys Ser Lys 
    1025                 1030                 1035             


Arg Thr  Gly Ile Ala Glu Lys  Ala Val Tyr Gln Gln  Phe Glu Lys 
    1040                 1045                 1050             


Met Leu  Ile Asp Lys Leu Asn  Cys Leu Val Leu Lys  Asp Tyr Pro 
    1055                 1060                 1065             


Ala Glu  Lys Val Gly Gly Val  Leu Asn Pro Tyr Gln  Leu Thr Asp 
    1070                 1075                 1080             


Gln Phe  Thr Ser Phe Ala Lys  Met Gly Thr Gln Ser  Gly Phe Leu 
    1085                 1090                 1095             


Phe Tyr  Val Pro Ala Pro Tyr  Thr Ser Lys Ile Asp  Pro Leu Thr 
    1100                 1105                 1110             


Gly Phe  Val Asp Pro Phe Val  Trp Lys Thr Ile Lys  Asn His Glu 
    1115                 1120                 1125             


Ser Arg  Lys His Phe Leu Glu  Gly Phe Asp Phe Leu  His Tyr Asp 
    1130                 1135                 1140             


Val Lys  Thr Gly Asp Phe Ile  Leu His Phe Lys Met  Asn Arg Asn 
    1145                 1150                 1155             


Leu Ser  Phe Gln Arg Gly Leu  Pro Gly Phe Met Pro  Ala Trp Asp 
    1160                 1165                 1170             


Ile Val  Phe Glu Lys Asn Glu  Thr Gln Phe Asp Ala  Lys Gly Thr 
    1175                 1180                 1185             


Pro Phe  Ile Ala Gly Lys Arg  Ile Val Pro Val Ile  Glu Asn His 
    1190                 1195                 1200             


Arg Phe  Thr Gly Arg Tyr Arg  Asp Leu Tyr Pro Ala  Asn Glu Leu 
    1205                 1210                 1215             


Ile Ala  Leu Leu Glu Glu Lys  Gly Ile Val Phe Arg  Asp Gly Ser 
    1220                 1225                 1230             


Asn Ile  Leu Pro Lys Leu Leu  Glu Asn Asp Asp Ser  His Ala Ile 
    1235                 1240                 1245             


Asp Thr  Met Val Ala Leu Ile  Arg Ser Val Leu Gln  Met Arg Asn 
    1250                 1255                 1260             


Ser Asn  Ala Ala Thr Gly Glu  Ala Tyr Ile Asn Ser  Pro Val Arg 
    1265                 1270                 1275             


Asp Leu  Asn Gly Val Cys Phe  Asp Ser Arg Phe Gln  Asn Pro Glu 
    1280                 1285                 1290             


Trp Pro  Met Asp Ala Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu 
    1295                 1300                 1305             


Lys Gly  Gln Leu Leu Leu Asn  His Leu Lys Glu Ser  Lys Asp Leu 
    1310                 1315                 1320             


Lys Leu  Gln Asn Gly Ile Ser  Asn Gln Asp Trp Leu  Ala Tyr Ile 
    1325                 1330                 1335             


Gln Glu  Leu Arg Asn Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1340                 1345                 1350         


<210>  69
<211>  1423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69

Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Met Pro Lys Lys Lys Arg Lys Val Gly Gly Gly Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60                  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ser Ile Tyr Gln Glu 
65                  70                  75                  80  


Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Glu Leu Ile 
                85                  90                  95      


Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys Ala Arg Gly Leu Ile Leu 
            100                 105                 110         


Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys Lys Ala Lys Gln Ile Ile 
        115                 120                 125             


Asp Lys Tyr His Gln Phe Phe Ile Glu Glu Ile Leu Ser Ser Val Cys 
    130                 135                 140                 


Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser Asp Val Tyr Phe Lys Leu 
145                 150                 155                 160 


Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys Asp Phe Lys Ser Ala Lys 
                165                 170                 175     


Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr Ile Lys Asp Ser Glu Lys 
            180                 185                 190         


Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile Asp Ala Lys Lys Gly Gln 
        195                 200                 205             


Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln Ser Lys Asp Asn Gly Ile 
    210                 215                 220                 


Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr Asp Ile Asp Glu Ala Leu 
225                 230                 235                 240 


Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr Thr Tyr Phe Lys Gly Phe 
                245                 250                 255     


His Glu Asn Arg Lys Asn Val Tyr Ser Ser Asn Asp Ile Pro Thr Ser 
            260                 265                 270         


Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu Pro Lys Phe Leu Glu Asn 
        275                 280                 285             


Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys Ala Pro Glu Ala Ile Asn 
    290                 295                 300                 


Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu Glu Leu Thr Phe Asp Ile 
305                 310                 315                 320 


Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg Val Phe Ser Leu Asp Glu 
                325                 330                 335     


Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr Leu Asn Gln Ser Gly Ile 
            340                 345                 350         


Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys Phe Val Asn Gly Glu Asn 
        355                 360                 365             


Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile Asn Leu Tyr Ser Gln Gln 
    370                 375                 380                 


Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys Met Ser Val Leu Phe Lys 
385                 390                 395                 400 


Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser Phe Val Ile Asp Lys Leu 
                405                 410                 415     


Glu Asp Asp Ser Asp Val Val Thr Thr Met Gln Ser Phe Tyr Glu Gln 
            420                 425                 430         


Ile Ala Ala Phe Lys Thr Val Glu Glu Lys Ser Ile Lys Glu Thr Leu 
        435                 440                 445             


Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln Lys Leu Asp Leu Ser Lys 
    450                 455                 460                 


Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr Asp Leu Ser Gln Gln Val 
465                 470                 475                 480 


Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala Val Leu Glu Tyr Ile Thr 
                485                 490                 495     


Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn Pro Ser Lys Lys Glu Gln 
            500                 505                 510         


Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala Lys Tyr Leu Ser Leu Glu 
        515                 520                 525             


Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn Lys His Arg Asp Ile Asp 
    530                 535                 540                 


Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala Asn Phe Ala Ala Ile Pro 
545                 550                 555                 560 


Met Ile Phe Asp Glu Ile Ala Gln Asn Lys Asp Asn Leu Ala Gln Ile 
                565                 570                 575     


Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys Asp Leu Leu Gln Ala Ser 
            580                 585                 590         


Ala Glu Asp Asp Val Lys Ala Ile Lys Asp Leu Leu Asp Gln Thr Asn 
        595                 600                 605             


Asn Leu Leu His Lys Leu Lys Ile Phe His Ile Ser Gln Ser Glu Asp 
    610                 615                 620                 


Lys Ala Asn Ile Leu Asp Lys Asp Glu His Phe Tyr Leu Val Phe Glu 
625                 630                 635                 640 


Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val Pro Leu Tyr Asn Lys Ile 
                645                 650                 655     


Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser Asp Glu Lys Phe Lys Leu 
            660                 665                 670         


Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly Trp Asp Lys Asn Lys Glu 
        675                 680                 685             


Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys Asp Asp Lys Tyr Tyr Leu 
    690                 695                 700                 


Gly Val Met Asn Lys Lys Asn Asn Lys Ile Phe Asp Asp Lys Ala Ile 
705                 710                 715                 720 


Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys Ile Val Tyr Lys Leu Leu 
                725                 730                 735     


Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Phe Ser Ala Lys Ser 
            740                 745                 750         


Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile Leu Arg Ile Arg Asn His 
        755                 760                 765             


Ser Thr His Thr Lys Asn Gly Ser Pro Gln Lys Gly Tyr Glu Lys Phe 
    770                 775                 780                 


Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe Ile Asp Phe Tyr Lys Gln 
785                 790                 795                 800 


Ser Ile Ser Lys His Pro Glu Trp Lys Asp Phe Gly Phe Arg Phe Ser 
                805                 810                 815     


Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu Phe Tyr Arg Glu Val Glu 
            820                 825                 830         


Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn Ile Ser Glu Ser Tyr Ile 
        835                 840                 845             


Asp Ser Val Val Asn Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn 
    850                 855                 860                 


Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg Pro Asn Leu His Thr Leu 
865                 870                 875                 880 


Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn Leu Gln Asp Val Val Tyr 
                885                 890                 895     


Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr Arg Lys Gln Ser Ile Pro 
            900                 905                 910         


Lys Lys Ile Thr His Pro Ala Lys Glu Ala Ile Ala Asn Lys Asn Lys 
        915                 920                 925             


Asp Asn Pro Lys Lys Glu Ser Val Phe Glu Tyr Asp Leu Ile Lys Asp 
    930                 935                 940                 


Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe His Cys Pro Ile Thr Ile 
945                 950                 955                 960 


Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe Asn Asp Glu Ile Asn Leu 
                965                 970                 975     


Leu Leu Lys Glu Lys Ala Asn Asp Val His Ile Leu Ser Ile Asp Arg 
            980                 985                 990         


Gly Glu Arg His Leu Ala Tyr Tyr  Thr Leu Val Asp Gly  Lys Gly Asn 
        995                 1000                 1005             


Ile Ile  Lys Gln Asp Thr Phe  Asn Ile Ile Gly Asn  Asp Arg Met 
    1010                 1015                 1020             


Lys Thr  Asn Tyr His Asp Lys  Leu Ala Ala Ile Glu  Lys Asp Arg 
    1025                 1030                 1035             


Asp Ser  Ala Arg Lys Asp Trp  Lys Lys Ile Asn Asn  Ile Lys Glu 
    1040                 1045                 1050             


Met Lys  Glu Gly Tyr Leu Ser  Gln Val Val His Glu  Ile Ala Lys 
    1055                 1060                 1065             


Leu Val  Ile Glu Tyr Asn Ala  Ile Val Val Phe Glu  Asp Leu Asn 
    1070                 1075                 1080             


Phe Gly  Phe Lys Arg Gly Arg  Phe Lys Val Glu Lys  Gln Val Tyr 
    1085                 1090                 1095             


Gln Lys  Leu Glu Lys Met Leu  Ile Glu Lys Leu Asn  Tyr Leu Val 
    1100                 1105                 1110             


Phe Lys  Asp Asn Glu Phe Asp  Lys Thr Gly Gly Val  Leu Arg Ala 
    1115                 1120                 1125             


Tyr Gln  Leu Thr Ala Pro Phe  Glu Thr Phe Lys Lys  Met Gly Lys 
    1130                 1135                 1140             


Gln Thr  Gly Ile Ile Tyr Tyr  Val Pro Ala Gly Phe  Thr Ser Lys 
    1145                 1150                 1155             


Ile Cys  Pro Val Thr Gly Phe  Val Asn Gln Leu Tyr  Pro Lys Tyr 
    1160                 1165                 1170             


Glu Ser  Val Ser Lys Ser Gln  Glu Phe Phe Ser Lys  Phe Asp Lys 
    1175                 1180                 1185             


Ile Cys  Tyr Asn Leu Asp Lys  Gly Tyr Phe Glu Phe  Ser Phe Asp 
    1190                 1195                 1200             


Tyr Lys  Asn Phe Gly Asp Lys  Ala Ala Lys Gly Lys  Trp Thr Ile 
    1205                 1210                 1215             


Ala Ser  Phe Gly Ser Arg Leu  Ile Asn Phe Arg Asn  Ser Asp Lys 
    1220                 1225                 1230             


Asn His  Asn Trp Asp Thr Arg  Glu Val Tyr Pro Thr  Lys Glu Leu 
    1235                 1240                 1245             


Glu Lys  Leu Leu Lys Asp Tyr  Ser Ile Glu Tyr Gly  His Gly Glu 
    1250                 1255                 1260             


Cys Ile  Lys Ala Ala Ile Cys  Gly Glu Ser Asp Lys  Lys Phe Phe 
    1265                 1270                 1275             


Ala Lys  Leu Thr Ser Val Leu  Asn Thr Ile Leu Gln  Met Arg Asn 
    1280                 1285                 1290             


Ser Lys  Thr Gly Thr Glu Leu  Asp Tyr Leu Ile Ser  Pro Val Ala 
    1295                 1300                 1305             


Asp Val  Asn Gly Asn Phe Phe  Asp Ser Arg Gln Ala  Pro Lys Asn 
    1310                 1315                 1320             


Met Pro  Gln Asp Ala Asp Ala  Asn Gly Ala Tyr His  Ile Gly Leu 
    1325                 1330                 1335             


Lys Gly  Leu Met Leu Leu Gly  Arg Ile Lys Asn Asn  Gln Glu Gly 
    1340                 1345                 1350             


Lys Lys  Leu Asn Leu Val Ile  Lys Asn Glu Glu Tyr  Phe Glu Phe 
    1355                 1360                 1365             


Val Gln  Asn Arg Asn Asn Pro  Lys Lys Lys Arg Lys  Val Ser Gly 
    1370                 1375                 1380             


Gly Ser  Ser Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val Tyr Pro 
    1385                 1390                 1395             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1400                 1405                 1410             


Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    1415                 1420             


<210>  70
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  71
<211>  23
<212>  DNA
<213>  Zea mays

<400>  71
attgatagag cacatgagct tgg                                               23


<210>  72
<211>  23
<212>  DNA
<213>  Zea mays

<400>  72
gtcacagatc acaaacttca aat                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Glycine max

<400>  73
gaacccttga gagaggcttc ttc                                               23


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  74
taatttctac taagtgtaga t                                                 21


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA

<400>  75
taatttctac tgttgtagat                                                   20


<210>  76
<211>  5358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
atgtccgagg tggagttcag ccacgagtac tggatgaggc acgctctcac cctggctaag       60

agggcgtggg acgagaggga ggtgccggtg ggcgccgtgc tcgtccacaa caaccgcgtg      120

atcggcgagg gctggaacag gcccatcggc aggcacgacc caaccgctca cgccgagatc      180

atggctctca ggcagggcgg cctggtcatg cagaactaca ggctgatcga cgcgaccctc      240

tacgtgaccc tcgagccctg cgtcatgtgc gcgggcgcca tgatccactc caggatcggc      300

agggtggtct tcggcgctag ggacgccaag acgggcgctg cgggcagcct catggacgtg      360

ctgcaccacc ccggcatgaa ccaccgcgtc gagatcaccg agggcatcct cgcggacgag      420

tgcgctgcgc tcctgtccga cttcttcagg atgcgcaggc aggagatcaa ggcccagaag      480

aaggcgcagt ccagcaccga ctccggcggc tccagcggcg gctccagcgg cagcgagacc      540

ccgggcacgt ccgagagcgc gacgcccgag agcagcggcg gctccagcgg cggctcctcg      600

gaggtcgagt tcagccatga gtactggatg aggcatgccc tgactctcgc taagagggcg      660

cgggatgagc gcgaggtgcc ggtgggggcc gtgctcgtcc tgaacaaccg cgtgatcggg      720

gagggctgga accgggctat cggcctccac gacccaacgg cccatgccga gatcatggcc      780

ctgaggcagg gcggcctggt catgcaaaac tacaggctca tcgacgccac cctctacgtg      840

accttcgagc catgcgtgat gtgcgcgggg gccatgatcc actcgaggat tgggagggtg      900

gtcttcggcg tgcgcaacgc taagacgggg gccgccggca gcctcatgga cgtcctgcac      960

tacccgggca tgaaccacag ggtggagatt accgagggca tcctggccga tgagtgcgcc     1020

gcgctcctgt gctacttctt ccgcatgccc aggcaggtct tcaacgcgca gaagaaggcc     1080

cagagctcca ctgattccgg cggctccagc ggcggctcca gtggcagcga gactcctggc     1140

acgtccgaga gcgccacgcc cgagtctagc ggcggctcca gcggcggctc cgacaagaag     1200

tacagcatcg gcctggcaat cggcaccaac agcgtgggct gggccgtgat caccgacgag     1260

tacaaggtgc cgagcaagaa gttcaaggtg ctgggcaaca ccgacaggca cagcatcaag     1320

aagaacctga tcggcgccct gctgttcgac agcggcgaga ccgccgaggc caccaggctg     1380

aagaggaccg ccaggaggag gtacaccagg aggaagaaca ggatctgcta cctgcaggag     1440

atcttcagca acgagatggc caaggtggac gacagcttct tccacaggct ggaggagagc     1500

ttcctggtgg aggaggacaa gaagcacgag aggcacccga tcttcggcaa catcgtggac     1560

gaggtggcct accacgagaa gtacccgacc atctaccacc tgaggaagaa gctggtggac     1620

agcaccgaca aggccgacct gaggctgatc tacctggccc tggcccacat gatcaagttc     1680

aggggccact tcctgatcga gggcgacctg aacccggaca acagcgacgt ggacaagctg     1740

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg agaacccgat caacgccagc     1800

ggcgtggacg ccaaggccat cctgagcgcc aggctgagca agagcaggag gctggagaac     1860

ctgatcgccc agctgccggg cgagaagaag aacggcctgt tcggcaacct gatcgccctg     1920

agcctgggcc tgaccccgaa cttcaagagc aacttcgacc tggccgagga cgccaagctg     1980

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac     2040

cagtacgccg acctgttcct ggccgccaag aacctgagcg acgccatcct gctgagcgac     2100

atcctgaggg tgaacaccga gatcaccaag gccccgctga gcgccagcat gatcaagagg     2160

tacgacgagc accaccagga cctgaccctg ctgaaggccc tggtgaggca gcagctgccg     2220

gagaagtaca aggagatctt cttcgaccag agcaagaacg gctacgccgg ctacatcgac     2280

ggcggcgcca gccaggagga gttctacaag ttcatcaagc cgatcctgga gaagatggac     2340

ggcaccgagg agctgctggt gaagctgaac agggaggacc tgctgaggaa gcagaggacc     2400

ttcgacaacg gcagcatccc gcaccagatc cacctgggcg agctgcacgc catcctgagg     2460

aggcaggagg acttctaccc gttcctgaag gacaacaggg agaagatcga gaagatcctg     2520

accttccgca tcccgtacta cgtgggcccg ctggccaggg gcaacagcag gttcgcctgg     2580

atgaccagga agagcgagga gaccatcacc ccgtggaact tcgaggaggt ggtggacaag     2640

ggcgccagcg cccagagctt catcgagagg atgaccaact tcgacaagaa cctgccgaac     2700

gagaaggtgc tgccgaagca cagcctgctg tacgagtact tcaccgtgta caacgagctg     2760

accaaggtga agtacgtgac cgagggcatg aggaagccgg ccttcctgag cggcgagcag     2820

aagaaggcca tcgtggacct gctgttcaag accaacagga aggtgaccgt gaagcagctg     2880

aaggaggact acttcaagaa gatcgagtgc ttcgacagcg tggagatcag cggcgtggag     2940

gacaggttca acgccagcct gggcacctac cacgacctgc tgaagatcat caaggacaag     3000

gacttcctgg acaacgagga gaacgaggac atcctggagg acatcgtgct gaccctgacc     3060

ctgttcgagg acagggagat gatcgaggag aggctgaaga cctacgccca cctgttcgac     3120

gacaaggtga tgaagcagct gaagaggagg aggtacaccg gctggggcag gctgagcagg     3180

aagctgatca acggcatcag ggacaagcag agcggcaaga ccatcctgga cttcctgaag     3240

agcgacggct tcgccaacag gaacttcatg cagctgatcc acgacgacag cctgaccttc     3300

aaggaggaca tccagaaggc ccaggtgagc ggccagggcg acagcctgca cgagcacatc     3360

gccaacctgg ccggcagccc ggccatcaag aagggcatcc tgcagaccgt gaaggtggtg     3420

gacgagctgg tgaaggtgat gggcaggcac aagccggaga acatcgtgat cgagatggcc     3480

agggagaacc agaccaccca gaagggccag aagaacagca gggagaggat gaagaggatc     3540

gaggagggca tcaaggagct gggcagccag atcctgaagg agcacccggt ggagaacacc     3600

cagctgcaga acgagaagct gtacctgtac tacctgcaga acggcaggga catgtacgtg     3660

gaccaggagc tggacatcaa caggctgagc gactacgacg tggaccacat cgtgccgcag     3720

agcttcctga aggacgacag catcgacaac aaggtgctga ccaggagcga caagaacagg     3780

ggcaagagcg acaacgtgcc gagcgaggag gtggtgaaga agatgaaaaa ctactggagg     3840

cagctgctga acgccaagct gatcacccag aggaagttcg acaacctgac caaggccgag     3900

aggggcggcc tgagcgagct ggacaaggcc ggcttcatta aaaggcagct ggtggagacc     3960

aggcagatca ccaagcacgt ggcccagatc ctggacagca ggatgaacac caagtacgac     4020

gagaacgaca agctgatcag ggaggtgaag gtgatcaccc tgaagagcaa gctggtgagc     4080

gacttcagga aggacttcca gttctacaag gtgagggaga tcaataatta ccaccacgcc     4140

cacgacgcct acctgaacgc cgtggtgggc accgccctga ttaaaaagta cccgaagctg     4200

gagagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgaggaagat gatcgccaag     4260

agcgagcagg agatcggcaa ggccaccgcc aagtacttct tctacagcaa catcatgaac     4320

ttcttcaaga ccgagatcac cctggccaac ggcgagatca ggaagaggcc gctgatcgag     4380

accaacggcg agaccggcga gatcgtgtgg gacaagggca gggacttcgc caccgtgagg     4440

aaggtgctgt ccatgccgca ggtgaacatc gtgaagaaga ccgaggtgca gaccggcggc     4500

ttcagcaagg agagcatcct gccgaagagg aacagcgaca agctgatcgc caggaagaag     4560

gactgggatc cgaagaagta cggcggcttc gacagcccga ccgtggccta cagcgtgctg     4620

gtggtggcca aggtggagaa gggcaagagc aagaagctga agagcgtgaa ggagctggtg     4680

ggcatcacca tcatggagag gagcagcttc gagaagaacc cagtggactt cctggaggcc     4740

aagggctaca aggaggtgaa gaaggacctg atcattaaac tgccgaagta cagcctgttc     4800

gagctggaga acggcaggaa gaggatgctg gccagcgccg gcgagctgca gaagggcaac     4860

gagctggccc tgccgagcaa gtacgtgaac ttcctgtacc tggccagcca ctacgagaag     4920

ctgaagggca gcccggagga caacgagcag aagcagctgt tcgtggagca gcacaagcac     4980

tacctggacg agatcatcga gcagatcagc gagttcagca agagggtgat cctggccgac     5040

gccaacctgg acaaggtgct gagcgcctac aacaagcaca gggacaagcc gatcagggag     5100

caggccgaga acatcatcca cctgttcacc ctgaccaacc tgggcgcccc ggccgccttc     5160

aagtacttcg acaccaccat cgacaggaag aggtacacca gcaccaagga ggtgctggac     5220

gccaccctga tccaccagag catcaccggc ctgtacgaga ccaggatcga cctgagccag     5280

ctgggcggcg acagcagccc gccgaagaag aagaggaagg tgagctggaa ggacgccagc     5340

ggctggagca ggatgtga                                                   5358


<210>  77
<211>  1785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  77

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Asp Lys Lys 
385                 390                 395                 400 


Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val 
                405                 410                 415     


Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly 
            420                 425                 430         


Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu 
        435                 440                 445             


Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala 
    450                 455                 460                 


Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu 
465                 470                 475                 480 


Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg 
                485                 490                 495     


Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His 
            500                 505                 510         


Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr 
        515                 520                 525             


Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys 
    530                 535                 540                 


Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe 
545                 550                 555                 560 


Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp 
                565                 570                 575     


Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe 
            580                 585                 590         


Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu 
        595                 600                 605             


Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln 
    610                 615                 620                 


Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu 
                645                 650                 655     


Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp 
            660                 665                 670         


Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala 
        675                 680                 685             


Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val 
    690                 695                 700                 


Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg 
705                 710                 715                 720 


Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg 
                725                 730                 735     


Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys 
            740                 745                 750         


Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe 
        755                 760                 765             


Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu 
    770                 775                 780                 


Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr 
785                 790                 795                 800 


Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His 
                805                 810                 815     


Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn 
            820                 825                 830         


Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val 
        835                 840                 845             


Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys 
    850                 855                 860                 


Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys 
865                 870                 875                 880 


Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys 
                885                 890                 895     


Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu 
            900                 905                 910         


Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu 
        915                 920                 925             


Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile 
    930                 935                 940                 


Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu 
945                 950                 955                 960 


Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile 
                965                 970                 975     


Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp 
            980                 985                 990         


Leu Leu Lys Ile Ile Lys Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn 
        995                 1000                 1005             


Glu Asp  Ile Leu Glu Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu 
    1010                 1015                 1020             


Asp Arg  Glu Met Ile Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu 
    1025                 1030                 1035             


Phe Asp  Asp Lys Val Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr 
    1040                 1045                 1050             


Gly Trp  Gly Arg Leu Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp 
    1055                 1060                 1065             


Lys Gln  Ser Gly Lys Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly 
    1070                 1075                 1080             


Phe Ala  Asn Arg Asn Phe Met  Gln Leu Ile His Asp  Asp Ser Leu 
    1085                 1090                 1095             


Thr Phe  Lys Glu Asp Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly 
    1100                 1105                 1110             


Asp Ser  Leu His Glu His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala 
    1115                 1120                 1125             


Ile Lys  Lys Gly Ile Leu Gln  Thr Val Lys Val Val  Asp Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Gly Arg His  Lys Pro Glu Asn Ile  Val Ile Glu 
    1145                 1150                 1155             


Met Ala  Arg Glu Asn Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser 
    1160                 1165                 1170             


Arg Glu  Arg Met Lys Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly 
    1175                 1180                 1185             


Ser Gln  Ile Leu Lys Glu His  Pro Val Glu Asn Thr  Gln Leu Gln 
    1190                 1195                 1200             


Asn Glu  Lys Leu Tyr Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met 
    1205                 1210                 1215             


Tyr Val  Asp Gln Glu Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp 
    1220                 1225                 1230             


Val Asp  His Ile Val Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile 
    1235                 1240                 1245             


Asp Asn  Lys Val Leu Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser 
    1250                 1255                 1260             


Asp Asn  Val Pro Ser Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr 
    1265                 1270                 1275             


Trp Arg  Gln Leu Leu Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe 
    1280                 1285                 1290             


Asp Asn  Leu Thr Lys Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp 
    1295                 1300                 1305             


Lys Ala  Gly Phe Ile Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile 
    1310                 1315                 1320             


Thr Lys  His Val Ala Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys 
    1325                 1330                 1335             


Tyr Asp  Glu Asn Asp Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr 
    1340                 1345                 1350             


Leu Lys  Ser Lys Leu Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe 
    1355                 1360                 1365             


Tyr Lys  Val Arg Glu Ile Asn  Asn Tyr His His Ala  His Asp Ala 
    1370                 1375                 1380             


Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro 
    1385                 1390                 1395             


Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp 
    1400                 1405                 1410             


Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala 
    1415                 1420                 1425             


Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys 
    1430                 1435                 1440             


Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu 
    1445                 1450                 1455             


Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly 
    1460                 1465                 1470             


Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu Ser Met  Pro Gln Val 
    1475                 1480                 1485             


Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys 
    1490                 1495                 1500             


Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg 
    1505                 1510                 1515             


Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro 
    1520                 1525                 1530             


Thr Val  Ala Tyr Ser Val Leu  Val Val Ala Lys Val  Glu Lys Gly 
    1535                 1540                 1545             


Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu Leu Val  Gly Ile Thr 
    1550                 1555                 1560             


Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn Pro Val  Asp Phe Leu 
    1565                 1570                 1575             


Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys 
    1580                 1585                 1590             


Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg 
    1595                 1600                 1605             


Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala 
    1610                 1615                 1620             


Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr 
    1625                 1630                 1635             


Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu 
    1640                 1645                 1650             


Phe Val  Glu Gln His Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln 
    1655                 1660                 1665             


Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu 
    1670                 1675                 1680             


Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile 
    1685                 1690                 1695             


Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn 
    1700                 1705                 1710             


Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp 
    1715                 1720                 1725             


Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu 
    1730                 1735                 1740             


Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu 
    1745                 1750                 1755             


Ser Gln  Leu Gly Gly Asp Ser  Ser Pro Pro Lys Lys  Lys Arg Lys 
    1760                 1765                 1770             


Val Ser  Trp Lys Asp Ala Ser  Gly Trp Ser Arg Met  
    1775                 1780                 1785 


<210>  78
<211>  5094
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntheic

<400>  78
atgtccgagg tggagttcag ccacgagtac tggatgaggc acgctctcac cctggctaag       60

agggcgtggg acgagaggga ggtgccggtg ggcgccgtgc tcgtccacaa caaccgcgtg      120

atcggcgagg gctggaacag gcccatcggc aggcacgacc caaccgctca cgccgagatc      180

atggctctca ggcagggcgg cctggtcatg cagaactaca ggctgatcga cgcgaccctc      240

tacgtgaccc tcgagccctg cgtcatggta agtttctgct tctacctttg atatatatat      300

aataattatc attaattagt agtaatataa tatttcaaat atttttttca aaataaaaga      360

atgtagtata tagcaattgc ttttctgtag tttataagtg tgtatatttt aatttataac      420

ttttctaata tatgaccaaa atttgttgat gtgcagtgcg cgggcgccat gatccactcc      480

aggatcggca gggtggtctt cggcgctagg gacgccaaga cgggcgctgc gggcagcctc      540

atggacgtgc tgcaccaccc cggcatgaac caccgcgtcg agatcaccga gggcatcctc      600

gcggacgagt gcgctgcgct cctgtccgac ttcttcagga tgcgcaggca ggagatcaag      660

gcccagaaga aggcgcagtc cagcaccgac tccggcggct ccagcggcgg ctccagcggc      720

agcgagaccc cgggcacgtc cgagagcgcg acgcccgaga gcagcggcgg ctccagcggc      780

ggctcctcgg aggtcgagtt cagccatgag tactggatga ggcatgccct gactctcgct      840

aagagggcgc gggatgagcg cgaggtgccg gtgggggccg tgctcgtcct gaacaaccgc      900

gtgatcgggg agggctggaa ccgggctatc ggcctccacg acccaacggc ccatgccgag      960

atcatggccc tgaggcaggg cggcctggtc atgcaaaact acaggctcat cgacgccacc     1020

ctctacgtga ccttcgagcc atgcgtgatg tgcgcggggg ccatgatcca ctcgaggatt     1080

gggagggtgg tcttcggcgt gcgcaacgct aagacggggg ccgccggcag cctcatggac     1140

gtcctgcact acccgggcat gaaccacagg gtggagatta ccgagggcat cctggccgat     1200

gagtgcgccg cgctcctgtg ctacttcttc cgcatgccca ggcaggtctt caacgcgcag     1260

aagaaggccc agagctccac tgattccggc ggctccagcg gcggctccag tggcagcgag     1320

actcctggca cgtccgagag cgccacgccc gagtctagcg gcggctccag cggcggctcc     1380

atgagcaagc tggagaagtt cacgaactgc tactccctca gcaagaccct gaggttcaag     1440

gcgatcccgg tcggcaagac ccaggagaac atcgacaaca agcggctgct ggtggaggac     1500

gagaagaggg ctgaggacta caagggcgtg aagaagctcc tggaccgcta ctacctgtcc     1560

ttcatcaacg acgtgctcca cagcatcaag ctcaagaacc tgaacaacta catcagcctc     1620

ttcaggaaga agacgcgcac cgagaaggag aacaaggagc tcgagaacct ggagatcaac     1680

ctgaggaagg agatcgccaa ggcgttcaag ggcaacgagg gctacaagtc cctcttcaag     1740

aaggacatca tcgagacgat cctcccggag ttcctggacg acaaggacga gatcgccctg     1800

gtcaactcct tcaacggctt caccacggcg ttcaccggct tcttcgacaa ccgcgagaac     1860

atgttcagcg aggaggccaa gtccacgagc atcgcgttca ggtgcatcaa cgagaacctc     1920

acccgctaca tctccaacat ggacatcttc gagaaggtcg acgcgatctt cgacaagcac     1980

gaggtgcagg agatcaagga gaagatcctg aacagcgact acgacgtcga ggacttcttc     2040

gagggcgagt tcttcaactt cgtcctcacg caggagggca tcgacgtgta caacgccatc     2100

atcggtggct tcgtgaccga gtccggcgag aagatcaagg gcctgaacga gtacatcaac     2160

ctctacaacc agaagaccaa gcagaagctg ccgaagttca agcccctgta caagcaggtg     2220

ctctccgaca gggagtccct cagcttctac ggcgagggct acacgagcga cgaggaggtc     2280

ctggaggtgt tccgcaacac cctcaacaag aacagcgaga tcttctccag catcaagaag     2340

ctcgagaagc tgttcaagaa cttcgacgag tactccagcg ccggcatctt cgtcaagaac     2400

ggcccggcga tctccacgat cagcaaggac atcttcggcg agtggaacgt gatccgcgac     2460

aagtggaacg ccgagtacga cgacatccac ctcaagaaga aggcggtggt caccgagaag     2520

tacgaggacg acaggcgcaa gtccttcaag aagatcggct ccttcagcct cgagcagctg     2580

caggagtacg ccgacgcgga cctgagcgtg gtcgagaagc tcaaggagat catcatccag     2640

aaggtcgacg agatctacaa ggtgtacggc tccagcgaga agctcttcga cgcggacttc     2700

gtcctcgaga agtccctgaa gaagaacgac gccgtggtcg cgatcatgaa ggacctcctg     2760

gactccgtga agagcttcga gaattacatc aaggccttct tcggcgaggg caaggagacg     2820

aacagggacg agtccttcta cggcgacttc gtcctggcct acgacatcct cctgaaggtg     2880

gaccacatct acgacgcgat ccgcaactac gtgacccaga agccgtacag caaggacaag     2940

ttcaagctct acttccagaa cccccagttc atgggcggct gggacaagga caaggagacg     3000

gactacaggg cgaccatcct gcgctacggc agcaagtact acctcgccat catggacaag     3060

aagtacgcga agtgcctgca gaagatcgac aaggacgacg tcaacggcaa ctacgagaag     3120

atcaactaca agctcctgcc gggccccaac aagatgctcc cgaaggtgtt cttctccaag     3180

aagtggatgg cctactacaa ccccagcgag gacatccaga agatctacaa gaacggcacg     3240

ttcaagaagg gcgacatgtt caacctgaac gactgccaca agctcatcga cttcttcaag     3300

gactccatca gccgctaccc gaagtggtcc aacgcctacg acttcaactt cagcgagacc     3360

gagaagtaca aggacatcgc gggcttctac cgcgaggtcg aggagcaggg ctacaaggtg     3420

tccttcgagt ccgccagcaa gaaggaggtc gacaagctgg tggaggaggg caagctctac     3480

atgttccaga tctacaacaa ggacttctcc gacaagagcc acggcacgcc caacctgcac     3540

accatgtact tcaagctcct gttcgacgag aacaaccacg gccagatcag gctgtccggc     3600

ggcgccgagc tcttcatgag gagggcgagc ctgaagaagg aggagctggt ggtccacccc     3660

gctaacagcc caatcgcgaa caagaacccg gacaacccca agaagaccac gaccctgtcc     3720

tacgacgtgt acaaggacaa gaggttcagc gaggaccagt acgagctcca catcccgatc     3780

gcgatcaaca agtgccccaa gaacatcttc aagatcaaca ccgaggtccg cgtgctcctg     3840

aagcacgacg acaaccccta cgtgatcggc atcgctaggg gcgagaggaa cctcctgtac     3900

atcgtggtcg tggacggcaa gggcaacatc gtggagcagt actccctcaa cgagatcatc     3960

aacaacttca acggcatcag gatcaagacg gactaccaca gcctcctgga caagaaggag     4020

aaggagaggt tcgaggcccg ccagaactgg acctccatcg agaacatcaa ggagctgaag     4080

gcgggctaca tcagccaggt cgtgcacaag atctgcgagc tcgtcgagaa gtacgacgcc     4140

gtgatcgccc tcgcggacct gaactccggc ttcaagaaca gccgcgtcaa ggtggagaag     4200

caggtctacc agaagttcga gaagatgctc atcgacaagc tgaactacat ggtggacaag     4260

aagtccaacc cctgcgctac gggcggcgcg ctgaagggct accagatcac caacaagttc     4320

gagagcttca agtccatgag cactcagaac ggcttcatct tctacatccc ggcgtggctc     4380

acgtccaaga tcgaccccag caccggcttc gtcaacctcc tgaagacgaa gtacacctcc     4440

atcgccgaca gcaagaagtt catctccagc ttcgaccgca tcatgtatgt gccggaggag     4500

gacctgttcg agttcgccct cgactacaag aacttctccc gcacggacgc ggactacatc     4560

aagaagtgga agctgtacag ctacggcaac cgcatccgca tcttcaggaa ccccaagaag     4620

aacaacgtct tcgactggga ggaggtgtgc ctgacctccg cgtacaagga gctcttcaac     4680

aagtacggca tcaactacca gcagggcgac atcagggctc tcctgtgcga gcagagcgac     4740

aaggccttct actccagctt catggcgctg atgtccctca tgctgcagat gaggaactcg     4800

atcaccggca ggacggacgt ggccttcctc atctccccgg tgaagaacag cgacggcatc     4860

ttctacgact ccaggaacta cgaggcccag gagaacgcga tcctcccaaa gaacgcggac     4920

gccaacggcg cctacaacat cgccaggaag gtcctctggg ctatcggcca gttcaagaag     4980

gcggaggacg agaagctgga caaggtgaag atcgccatca gcaacaagga gtggctcgag     5040

tacgcccaga cctcggtcaa gcacggcagc ccgaagaaga agcgcaaggt gtga           5094


<210>  79
<211>  1691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  79

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Val Ser Phe Cys Phe Tyr Leu 
                85                  90                  95      


Tyr Ile Tyr Asn Asn Tyr His Leu Val Val Ile Tyr Phe Lys Tyr Phe 
            100                 105                 110         


Phe Gln Asn Lys Arg Met Tyr Ile Ala Ile Ala Phe Leu Phe Ile Ser 
        115                 120                 125             


Val Tyr Ile Leu Ile Tyr Asn Phe Ser Asn Ile Pro Lys Phe Val Asp 
    130                 135                 140                 


Val Gln Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val 
145                 150                 155                 160 


Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp 
                165                 170                 175     


Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly 
            180                 185                 190         


Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe Arg Met 
        195                 200                 205             


Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp 
    210                 215                 220                 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
225                 230                 235                 240 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
            260                 265                 270         


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
        275                 280                 285             


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
    290                 295                 300                 


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
305                 310                 315                 320 


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
                325                 330                 335     


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
            340                 345                 350         


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
        355                 360                 365             


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
    370                 375                 380                 


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
385                 390                 395                 400 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
                405                 410                 415     


Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
            420                 425                 430         


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly 
        435                 440                 445             


Gly Ser Ser Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn Cys 
    450                 455                 460                 


Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys 
465                 470                 475                 480 


Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys 
                485                 490                 495     


Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr 
            500                 505                 510         


Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu 
        515                 520                 525             


Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu 
    530                 535                 540                 


Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala 
545                 550                 555                 560 


Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp 
                565                 570                 575     


Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile 
            580                 585                 590         


Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe 
        595                 600                 605             


Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser 
    610                 615                 620                 


Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn 
625                 630                 635                 640 


Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val 
                645                 650                 655     


Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp 
            660                 665                 670         


Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile 
        675                 680                 685             


Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu 
    690                 695                 700                 


Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr 
705                 710                 715                 720 


Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser 
                725                 730                 735     


Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu 
            740                 745                 750         


Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile 
        755                 760                 765             


Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu 
    770                 775                 780                 


Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr 
785                 790                 795                 800 


Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp 
                805                 810                 815     


Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr 
            820                 825                 830         


Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser 
        835                 840                 845             


Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val 
    850                 855                 860                 


Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr 
865                 870                 875                 880 


Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu 
                885                 890                 895     


Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp 
            900                 905                 910         


Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe 
        915                 920                 925             


Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe 
    930                 935                 940                 


Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala 
945                 950                 955                 960 


Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys 
                965                 970                 975     


Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys 
            980                 985                 990         


Glu Thr Asp Tyr Arg Ala Thr Ile  Leu Arg Tyr Gly Ser  Lys Tyr Tyr 
        995                 1000                 1005             


Leu Ala  Ile Met Asp Lys Lys  Tyr Ala Lys Cys Leu  Gln Lys Ile 
    1010                 1015                 1020             


Asp Lys  Asp Asp Val Asn Gly  Asn Tyr Glu Lys Ile  Asn Tyr Lys 
    1025                 1030                 1035             


Leu Leu  Pro Gly Pro Asn Lys  Met Leu Pro Lys Val  Phe Phe Ser 
    1040                 1045                 1050             


Lys Lys  Trp Met Ala Tyr Tyr  Asn Pro Ser Glu Asp  Ile Gln Lys 
    1055                 1060                 1065             


Ile Tyr  Lys Asn Gly Thr Phe  Lys Lys Gly Asp Met  Phe Asn Leu 
    1070                 1075                 1080             


Asn Asp  Cys His Lys Leu Ile  Asp Phe Phe Lys Asp  Ser Ile Ser 
    1085                 1090                 1095             


Arg Tyr  Pro Lys Trp Ser Asn  Ala Tyr Asp Phe Asn  Phe Ser Glu 
    1100                 1105                 1110             


Thr Glu  Lys Tyr Lys Asp Ile  Ala Gly Phe Tyr Arg  Glu Val Glu 
    1115                 1120                 1125             


Glu Gln  Gly Tyr Lys Val Ser  Phe Glu Ser Ala Ser  Lys Lys Glu 
    1130                 1135                 1140             


Val Asp  Lys Leu Val Glu Glu  Gly Lys Leu Tyr Met  Phe Gln Ile 
    1145                 1150                 1155             


Tyr Asn  Lys Asp Phe Ser Asp  Lys Ser His Gly Thr  Pro Asn Leu 
    1160                 1165                 1170             


His Thr  Met Tyr Phe Lys Leu  Leu Phe Asp Glu Asn  Asn His Gly 
    1175                 1180                 1185             


Gln Ile  Arg Leu Ser Gly Gly  Ala Glu Leu Phe Met  Arg Arg Ala 
    1190                 1195                 1200             


Ser Leu  Lys Lys Glu Glu Leu  Val Val His Pro Ala  Asn Ser Pro 
    1205                 1210                 1215             


Ile Ala  Asn Lys Asn Pro Asp  Asn Pro Lys Lys Thr  Thr Thr Leu 
    1220                 1225                 1230             


Ser Tyr  Asp Val Tyr Lys Asp  Lys Arg Phe Ser Glu  Asp Gln Tyr 
    1235                 1240                 1245             


Glu Leu  His Ile Pro Ile Ala  Ile Asn Lys Cys Pro  Lys Asn Ile 
    1250                 1255                 1260             


Phe Lys  Ile Asn Thr Glu Val  Arg Val Leu Leu Lys  His Asp Asp 
    1265                 1270                 1275             


Asn Pro  Tyr Val Ile Gly Ile  Ala Arg Gly Glu Arg  Asn Leu Leu 
    1280                 1285                 1290             


Tyr Ile  Val Val Val Asp Gly  Lys Gly Asn Ile Val  Glu Gln Tyr 
    1295                 1300                 1305             


Ser Leu  Asn Glu Ile Ile Asn  Asn Phe Asn Gly Ile  Arg Ile Lys 
    1310                 1315                 1320             


Thr Asp  Tyr His Ser Leu Leu  Asp Lys Lys Glu Lys  Glu Arg Phe 
    1325                 1330                 1335             


Glu Ala  Arg Gln Asn Trp Thr  Ser Ile Glu Asn Ile  Lys Glu Leu 
    1340                 1345                 1350             


Lys Ala  Gly Tyr Ile Ser Gln  Val Val His Lys Ile  Cys Glu Leu 
    1355                 1360                 1365             


Val Glu  Lys Tyr Asp Ala Val  Ile Ala Leu Ala Asp  Leu Asn Ser 
    1370                 1375                 1380             


Gly Phe  Lys Asn Ser Arg Val  Lys Val Glu Lys Gln  Val Tyr Gln 
    1385                 1390                 1395             


Lys Phe  Glu Lys Met Leu Ile  Asp Lys Leu Asn Tyr  Met Val Asp 
    1400                 1405                 1410             


Lys Lys  Ser Asn Pro Cys Ala  Thr Gly Gly Ala Leu  Lys Gly Tyr 
    1415                 1420                 1425             


Gln Ile  Thr Asn Lys Phe Glu  Ser Phe Lys Ser Met  Ser Thr Gln 
    1430                 1435                 1440             


Asn Gly  Phe Ile Phe Tyr Ile  Pro Ala Trp Leu Thr  Ser Lys Ile 
    1445                 1450                 1455             


Asp Pro  Ser Thr Gly Phe Val  Asn Leu Leu Lys Thr  Lys Tyr Thr 
    1460                 1465                 1470             


Ser Ile  Ala Asp Ser Lys Lys  Phe Ile Ser Ser Phe  Asp Arg Ile 
    1475                 1480                 1485             


Met Tyr  Val Pro Glu Glu Asp  Leu Phe Glu Phe Ala  Leu Asp Tyr 
    1490                 1495                 1500             


Lys Asn  Phe Ser Arg Thr Asp  Ala Asp Tyr Ile Lys  Lys Trp Lys 
    1505                 1510                 1515             


Leu Tyr  Ser Tyr Gly Asn Arg  Ile Arg Ile Phe Arg  Asn Pro Lys 
    1520                 1525                 1530             


Lys Asn  Asn Val Phe Asp Trp  Glu Glu Val Cys Leu  Thr Ser Ala 
    1535                 1540                 1545             


Tyr Lys  Glu Leu Phe Asn Lys  Tyr Gly Ile Asn Tyr  Gln Gln Gly 
    1550                 1555                 1560             


Asp Ile  Arg Ala Leu Leu Cys  Glu Gln Ser Asp Lys  Ala Phe Tyr 
    1565                 1570                 1575             


Ser Ser  Phe Met Ala Leu Met  Ser Leu Met Leu Gln  Met Arg Asn 
    1580                 1585                 1590             


Ser Ile  Thr Gly Arg Thr Asp  Val Ala Phe Leu Ile  Ser Pro Val 
    1595                 1600                 1605             


Lys Asn  Ser Asp Gly Ile Phe  Tyr Asp Ser Arg Asn  Tyr Glu Ala 
    1610                 1615                 1620             


Gln Glu  Asn Ala Ile Leu Pro  Lys Asn Ala Asp Ala  Asn Gly Ala 
    1625                 1630                 1635             


Tyr Asn  Ile Ala Arg Lys Val  Leu Trp Ala Ile Gly  Gln Phe Lys 
    1640                 1645                 1650             


Lys Ala  Glu Asp Glu Lys Leu  Asp Lys Val Lys Ile  Ala Ile Ser 
    1655                 1660                 1665             


Asn Lys  Glu Trp Leu Glu Tyr  Ala Gln Thr Ser Val  Lys His Gly 
    1670                 1675                 1680             


Ser Pro  Lys Lys Lys Arg Lys  Val 
    1685                 1690     


<210>  80
<211>  5088
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
atgtccgagg tggagttcag ccacgagtac tggatgaggc acgctctcac cctggctaag       60

agggcgtggg acgagaggga ggtgccggtg ggcgccgtgc tcgtccacaa caaccgcgtg      120

atcggcgagg gctggaacag gcccatcggc aggcacgacc caaccgctca cgccgagatc      180

atggctctca ggcagggcgg cctggtcatg cagaactaca ggctgatcga cgcgaccctc      240

tacgtgaccc tcgagccctg cgtcatggta agtttctgct tctacctttg atatatatat      300

aataattatc attaattagt agtaatataa tatttcaaat atttttttca aaataaaaga      360

atgtagtata tagcaattgc ttttctgtag tttataagtg tgtatatttt aatttataac      420

ttttctaata tatgaccaaa atttgttgat gtgcagtgcg cgggcgccat gatccactcc      480

aggatcggca gggtggtctt cggcgctagg gacgccaaga cgggcgctgc gggcagcctc      540

atggacgtgc tgcaccaccc cggcatgaac caccgcgtcg agatcaccga gggcatcctc      600

gcggacgagt gcgctgcgct cctgtccgac ttcttcagga tgcgcaggca ggagatcaag      660

gcccagaaga aggcgcagtc cagcaccgac tccggcggct ccagcggcgg ctccagcggc      720

agcgagaccc cgggcacgtc cgagagcgcg acgcccgaga gcagcggcgg ctccagcggc      780

ggctcctcgg aggtcgagtt cagccatgag tactggatga ggcatgccct gactctcgct      840

aagagggcgc gggatgagcg cgaggtgccg gtgggggccg tgctcgtcct gaacaaccgc      900

gtgatcgggg agggctggaa ccgggctatc ggcctccacg acccaacggc ccatgccgag      960

atcatggccc tgaggcaggg cggcctggtc atgcaaaact acaggctcat cgacgccacc     1020

ctctacgtga ccttcgagcc atgcgtgatg tgcgcggggg ccatgatcca ctcgaggatt     1080

gggagggtgg tcttcggcgt gcgcaacgct aagacggggg ccgccggcag cctcatggac     1140

gtcctgcact acccgggcat gaaccacagg gtggagatta ccgagggcat cctggccgat     1200

gagtgcgccg cgctcctgtg ctacttcttc cgcatgccca ggcaggtctt caacgcgcag     1260

aagaaggccc agagctccac tgatgggggc gggggctcag gcgggggcgg gagcggcggc     1320

gggggctctg ggggcggcgg cagcggcggg ggcggcagcg ggggcggcgg gtcgatgagc     1380

aagctggaga agttcacgaa ctgctactcc ctcagcaaga ccctgaggtt caaggcgatc     1440

ccggtcggca agacccagga gaacatcgac aacaagcggc tgctggtgga ggacgagaag     1500

agggctgagg actacaaggg cgtgaagaag ctcctggacc gctactacct gtccttcatc     1560

aacgacgtgc tccacagcat caagctcaag aacctgaaca actacatcag cctcttcagg     1620

aagaagacgc gcaccgagaa ggagaacaag gagctcgaga acctggagat caacctgagg     1680

aaggagatcg ccaaggcgtt caagggcaac gagggctaca agtccctctt caagaaggac     1740

atcatcgaga cgatcctccc ggagttcctg gacgacaagg acgagatcgc cctggtcaac     1800

tccttcaacg gcttcaccac ggcgttcacc ggcttcttcg acaaccgcga gaacatgttc     1860

agcgaggagg ccaagtccac gagcatcgcg ttcaggtgca tcaacgagaa cctcacccgc     1920

tacatctcca acatggacat cttcgagaag gtcgacgcga tcttcgacaa gcacgaggtg     1980

caggagatca aggagaagat cctgaacagc gactacgacg tcgaggactt cttcgagggc     2040

gagttcttca acttcgtcct cacgcaggag ggcatcgacg tgtacaacgc catcatcggt     2100

ggcttcgtga ccgagtccgg cgagaagatc aagggcctga acgagtacat caacctctac     2160

aaccagaaga ccaagcagaa gctgccgaag ttcaagcccc tgtacaagca ggtgctctcc     2220

gacagggagt ccctcagctt ctacggcgag ggctacacga gcgacgagga ggtcctggag     2280

gtgttccgca acaccctcaa caagaacagc gagatcttct ccagcatcaa gaagctcgag     2340

aagctgttca agaacttcga cgagtactcc agcgccggca tcttcgtcaa gaacggcccg     2400

gcgatctcca cgatcagcaa ggacatcttc ggcgagtgga acgtgatccg cgacaagtgg     2460

aacgccgagt acgacgacat ccacctcaag aagaaggcgg tggtcaccga gaagtacgag     2520

gacgacaggc gcaagtcctt caagaagatc ggctccttca gcctcgagca gctgcaggag     2580

tacgccgacg cggacctgag cgtggtcgag aagctcaagg agatcatcat ccagaaggtc     2640

gacgagatct acaaggtgta cggctccagc gagaagctct tcgacgcgga cttcgtcctc     2700

gagaagtccc tgaagaagaa cgacgccgtg gtcgcgatca tgaaggacct cctggactcc     2760

gtgaagagct tcgagaatta catcaaggcc ttcttcggcg agggcaagga gacgaacagg     2820

gacgagtcct tctacggcga cttcgtcctg gcctacgaca tcctcctgaa ggtggaccac     2880

atctacgacg cgatccgcaa ctacgtgacc cagaagccgt acagcaagga caagttcaag     2940

ctctacttcc agaaccccca gttcatgggc ggctgggaca aggacaagga gacggactac     3000

agggcgacca tcctgcgcta cggcagcaag tactacctcg ccatcatgga caagaagtac     3060

gcgaagtgcc tgcagaagat cgacaaggac gacgtcaacg gcaactacga gaagatcaac     3120

tacaagctcc tgccgggccc caacaagatg ctcccgaagg tgttcttctc caagaagtgg     3180

atggcctact acaaccccag cgaggacatc cagaagatct acaagaacgg cacgttcaag     3240

aagggcgaca tgttcaacct gaacgactgc cacaagctca tcgacttctt caaggactcc     3300

atcagccgct acccgaagtg gtccaacgcc tacgacttca acttcagcga gaccgagaag     3360

tacaaggaca tcgcgggctt ctaccgcgag gtcgaggagc agggctacaa ggtgtccttc     3420

gagtccgcca gcaagaagga ggtcgacaag ctggtggagg agggcaagct ctacatgttc     3480

cagatctaca acaaggactt ctccgacaag agccacggca cgcccaacct gcacaccatg     3540

tacttcaagc tcctgttcga cgagaacaac cacggccaga tcaggctgtc cggcggcgcc     3600

gagctcttca tgaggagggc gagcctgaag aaggaggagc tggtggtcca ccccgctaac     3660

agcccaatcg cgaacaagaa cccggacaac cccaagaaga ccacgaccct gtcctacgac     3720

gtgtacaagg acaagaggtt cagcgaggac cagtacgagc tccacatccc gatcgcgatc     3780

aacaagtgcc ccaagaacat cttcaagatc aacaccgagg tccgcgtgct cctgaagcac     3840

gacgacaacc cctacgtgat cggcatcgct aggggcgaga ggaacctcct gtacatcgtg     3900

gtcgtggacg gcaagggcaa catcgtggag cagtactccc tcaacgagat catcaacaac     3960

ttcaacggca tcaggatcaa gacggactac cacagcctcc tggacaagaa ggagaaggag     4020

aggttcgagg cccgccagaa ctggacctcc atcgagaaca tcaaggagct gaaggcgggc     4080

tacatcagcc aggtcgtgca caagatctgc gagctcgtcg agaagtacga cgccgtgatc     4140

gccctcgcgg acctgaactc cggcttcaag aacagccgcg tcaaggtgga gaagcaggtc     4200

taccagaagt tcgagaagat gctcatcgac aagctgaact acatggtgga caagaagtcc     4260

aacccctgcg ctacgggcgg cgcgctgaag ggctaccaga tcaccaacaa gttcgagagc     4320

ttcaagtcca tgagcactca gaacggcttc atcttctaca tcccggcgtg gctcacgtcc     4380

aagatcgacc ccagcaccgg cttcgtcaac ctcctgaaga cgaagtacac ctccatcgcc     4440

gacagcaaga agttcatctc cagcttcgac cgcatcatgt atgtgccgga ggaggacctg     4500

ttcgagttcg ccctcgacta caagaacttc tcccgcacgg acgcggacta catcaagaag     4560

tggaagctgt acagctacgg caaccgcatc cgcatcttca ggaaccccaa gaagaacaac     4620

gtcttcgact gggaggaggt gtgcctgacc tccgcgtaca aggagctctt caacaagtac     4680

ggcatcaact accagcaggg cgacatcagg gctctcctgt gcgagcagag cgacaaggcc     4740

ttctactcca gcttcatggc gctgatgtcc ctcatgctgc agatgaggaa ctcgatcacc     4800

ggcaggacgg acgtggcctt cctcatctcc ccggtgaaga acagcgacgg catcttctac     4860

gactccagga actacgaggc ccaggagaac gcgatcctcc caaagaacgc ggacgccaac     4920

ggcgcctaca acatcgccag gaaggtcctc tgggctatcg gccagttcaa gaaggcggag     4980

gacgagaagc tggacaaggt gaagatcgcc atcagcaaca aggagtggct cgagtacgcc     5040

cagacctcgg tcaagcacgg cagcccgaag aagaagcgca aggtgtga                  5088


<210>  81
<211>  1689
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  81

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Val Ser Phe Cys Phe Tyr Leu 
                85                  90                  95      


Tyr Ile Tyr Asn Asn Tyr His Leu Val Val Ile Tyr Phe Lys Tyr Phe 
            100                 105                 110         


Phe Gln Asn Lys Arg Met Tyr Ile Ala Ile Ala Phe Leu Phe Ile Ser 
        115                 120                 125             


Val Tyr Ile Leu Ile Tyr Asn Phe Ser Asn Ile Pro Lys Phe Val Asp 
    130                 135                 140                 


Val Gln Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val 
145                 150                 155                 160 


Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp 
                165                 170                 175     


Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly 
            180                 185                 190         


Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe Arg Met 
        195                 200                 205             


Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp 
    210                 215                 220                 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
225                 230                 235                 240 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
            260                 265                 270         


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
        275                 280                 285             


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
    290                 295                 300                 


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
305                 310                 315                 320 


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
                325                 330                 335     


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
            340                 345                 350         


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
        355                 360                 365             


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
    370                 375                 380                 


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
385                 390                 395                 400 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
                405                 410                 415     


Ala Gln Ser Ser Thr Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser 
    450                 455                 460                 


Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln 
465                 470                 475                 480 


Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala 
                485                 490                 495     


Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser 
            500                 505                 510         


Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn 
        515                 520                 525             


Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys 
    530                 535                 540                 


Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala 
545                 550                 555                 560 


Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile 
                565                 570                 575     


Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu 
            580                 585                 590         


Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp 
        595                 600                 605             


Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala 
    610                 615                 620                 


Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp 
625                 630                 635                 640 


Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu 
                645                 650                 655     


Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe 
            660                 665                 670         


Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val 
        675                 680                 685             


Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile 
    690                 695                 700                 


Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln 
705                 710                 715                 720 


Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg 
                725                 730                 735     


Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val 
            740                 745                 750         


Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser 
        755                 760                 765             


Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser 
    770                 775                 780                 


Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser 
785                 790                 795                 800 


Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala 
                805                 810                 815     


Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys 
            820                 825                 830         


Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser 
        835                 840                 845             


Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu 
    850                 855                 860                 


Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val 
865                 870                 875                 880 


Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys 
                885                 890                 895     


Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu 
            900                 905                 910         


Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu 
        915                 920                 925             


Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu 
    930                 935                 940                 


Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg 
945                 950                 955                 960 


Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr 
                965                 970                 975     


Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr 
            980                 985                 990         


Asp Tyr Arg Ala Thr Ile Leu Arg  Tyr Gly Ser Lys Tyr  Tyr Leu Ala 
        995                 1000                 1005             


Ile Met  Asp Lys Lys Tyr Ala  Lys Cys Leu Gln Lys  Ile Asp Lys 
    1010                 1015                 1020             


Asp Asp  Val Asn Gly Asn Tyr  Glu Lys Ile Asn Tyr  Lys Leu Leu 
    1025                 1030                 1035             


Pro Gly  Pro Asn Lys Met Leu  Pro Lys Val Phe Phe  Ser Lys Lys 
    1040                 1045                 1050             


Trp Met  Ala Tyr Tyr Asn Pro  Ser Glu Asp Ile Gln  Lys Ile Tyr 
    1055                 1060                 1065             


Lys Asn  Gly Thr Phe Lys Lys  Gly Asp Met Phe Asn  Leu Asn Asp 
    1070                 1075                 1080             


Cys His  Lys Leu Ile Asp Phe  Phe Lys Asp Ser Ile  Ser Arg Tyr 
    1085                 1090                 1095             


Pro Lys  Trp Ser Asn Ala Tyr  Asp Phe Asn Phe Ser  Glu Thr Glu 
    1100                 1105                 1110             


Lys Tyr  Lys Asp Ile Ala Gly  Phe Tyr Arg Glu Val  Glu Glu Gln 
    1115                 1120                 1125             


Gly Tyr  Lys Val Ser Phe Glu  Ser Ala Ser Lys Lys  Glu Val Asp 
    1130                 1135                 1140             


Lys Leu  Val Glu Glu Gly Lys  Leu Tyr Met Phe Gln  Ile Tyr Asn 
    1145                 1150                 1155             


Lys Asp  Phe Ser Asp Lys Ser  His Gly Thr Pro Asn  Leu His Thr 
    1160                 1165                 1170             


Met Tyr  Phe Lys Leu Leu Phe  Asp Glu Asn Asn His  Gly Gln Ile 
    1175                 1180                 1185             


Arg Leu  Ser Gly Gly Ala Glu  Leu Phe Met Arg Arg  Ala Ser Leu 
    1190                 1195                 1200             


Lys Lys  Glu Glu Leu Val Val  His Pro Ala Asn Ser  Pro Ile Ala 
    1205                 1210                 1215             


Asn Lys  Asn Pro Asp Asn Pro  Lys Lys Thr Thr Thr  Leu Ser Tyr 
    1220                 1225                 1230             


Asp Val  Tyr Lys Asp Lys Arg  Phe Ser Glu Asp Gln  Tyr Glu Leu 
    1235                 1240                 1245             


His Ile  Pro Ile Ala Ile Asn  Lys Cys Pro Lys Asn  Ile Phe Lys 
    1250                 1255                 1260             


Ile Asn  Thr Glu Val Arg Val  Leu Leu Lys His Asp  Asp Asn Pro 
    1265                 1270                 1275             


Tyr Val  Ile Gly Ile Ala Arg  Gly Glu Arg Asn Leu  Leu Tyr Ile 
    1280                 1285                 1290             


Val Val  Val Asp Gly Lys Gly  Asn Ile Val Glu Gln  Tyr Ser Leu 
    1295                 1300                 1305             


Asn Glu  Ile Ile Asn Asn Phe  Asn Gly Ile Arg Ile  Lys Thr Asp 
    1310                 1315                 1320             


Tyr His  Ser Leu Leu Asp Lys  Lys Glu Lys Glu Arg  Phe Glu Ala 
    1325                 1330                 1335             


Arg Gln  Asn Trp Thr Ser Ile  Glu Asn Ile Lys Glu  Leu Lys Ala 
    1340                 1345                 1350             


Gly Tyr  Ile Ser Gln Val Val  His Lys Ile Cys Glu  Leu Val Glu 
    1355                 1360                 1365             


Lys Tyr  Asp Ala Val Ile Ala  Leu Ala Asp Leu Asn  Ser Gly Phe 
    1370                 1375                 1380             


Lys Asn  Ser Arg Val Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe 
    1385                 1390                 1395             


Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys 
    1400                 1405                 1410             


Ser Asn  Pro Cys Ala Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile 
    1415                 1420                 1425             


Thr Asn  Lys Phe Glu Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly 
    1430                 1435                 1440             


Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro 
    1445                 1450                 1455             


Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile 
    1460                 1465                 1470             


Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr 
    1475                 1480                 1485             


Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn 
    1490                 1495                 1500             


Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr 
    1505                 1510                 1515             


Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn 
    1520                 1525                 1530             


Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys 
    1535                 1540                 1545             


Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile 
    1550                 1555                 1560             


Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser 
    1565                 1570                 1575             


Phe Met  Ala Leu Met Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile 
    1580                 1585                 1590             


Thr Gly  Arg Thr Asp Val Ala  Phe Leu Ile Ser Pro  Val Lys Asn 
    1595                 1600                 1605             


Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu 
    1610                 1615                 1620             


Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1625                 1630                 1635             


Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala 
    1640                 1645                 1650             


Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys 
    1655                 1660                 1665             


Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val Lys His  Gly Ser Pro 
    1670                 1675                 1680             


Lys Lys  Lys Arg Lys Val 
    1685                 


<210>  82
<211>  4936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
atgccgaaga agaagcgcaa ggtcatgacc gacgcggagt atgtgcgcat ccacgagaag       60

ctcgacatct acaccttcaa gaagcagttc ttcaacaaca agaagagcgt ctcccacagg      120

tgctacgtgc tcttcgagct gaagaggcgc ggcgagcgca gggcctgctt ctggggctac      180

gccgtgaaca agccgcagag cggcaccgag cgcggcatcc acgccgagat cttcagcatc      240

cgcaaggtgg aggagtacct cagggacaac ccgggccagt tcaccatcaa ctggtacagc      300

tcctggagcc cggtaagttt ctgcttctac ctttgatata tatataataa ttatcattaa      360

ttagtagtaa tataatattt caaatatttt tttcaaaata aaagaatgta gtatatagca      420

attgcttttc tgtagtttat aagtgtgtat attttaattt ataacttttc taatatatga      480

ccaaaatttg ttgatgtgca gtgcgcggac tgcgccgaga agatcctgga gtggtacaac      540

caggagctga ggggcaacgg ccacaccctg aagatctggg cctgcaagct ctactacgag      600

aagaacgcga ggaaccagat cggcctgtgg aacctccgcg acaacggcgt cggcctcaac      660

gtgatggtct ccgagcacta ccagtgctgc cgcaagatct tcatccagtc cagccacaac      720

cagctcaacg agaacaggtg gctggagaag accctgaaga gggccgagaa gcgcaggtcc      780

gagctcagca tcatgatcca ggtgaagatc ctccacacca cgaagtcccc cgccgtgggg      840

gggcgggggc tcaggcgggg gcgggagcgg cggcgggggc tctgggggcg gcggcagcgg      900

cgggggcggc agcgggggcg gcgggtcgat gagcaagctg gagaagttca cgaactgcta      960

ctccctcagc aagaccctga ggttcaaggc gatcccggtc ggcaagaccc aggagaacat     1020

cgacaacaag cggctgctgg tggaggacga gaagagggct gaggactaca agggcgtgaa     1080

gaagctcctg gaccgctact acctgtcctt catcaacgac gtgctccaca gcatcaagct     1140

caagaacctg aacaactaca tcagcctctt caggaagaag acgcgcaccg agaaggagaa     1200

caaggagctc gagaacctgg agatcaacct gaggaaggag atcgccaagg cgttcaaggg     1260

caacgagggc tacaagtccc tcttcaagaa ggacatcatc gagacgatcc tcccggagtt     1320

cctggacgac aaggacgaga tcgccctggt caactccttc aacggcttca ccacggcgtt     1380

caccggcttc ttcgacaacc gcgagaacat gttcagcgag gaggccaagt ccacgagcat     1440

cgcgttcagg tgcatcaacg agaacctcac ccgctacatc tccaacatgg acatcttcga     1500

gaaggtcgac gcgatcttcg acaagcacga ggtgcaggag atcaaggaga agatcctgaa     1560

cagcgactac gacgtcgagg acttcttcga gggcgagttc ttcaacttcg tcctcacgca     1620

ggagggcatc gacgtgtaca acgccatcat cggtggcttc gtgaccgagt ccggcgagaa     1680

gatcaagggc ctgaacgagt acatcaacct ctacaaccag aagaccaagc agaagctgcc     1740

gaagttcaag cccctgtaca agcaggtgct ctccgacagg gagtccctca gcttctacgg     1800

cgagggctac acgagcgacg aggaggtcct ggaggtgttc cgcaacaccc tcaacaagaa     1860

cagcgagatc ttctccagca tcaagaagct cgagaagctg ttcaagaact tcgacgagta     1920

ctccagcgcc ggcatcttcg tcaagaacgg cccggcgatc tccacgatca gcaaggacat     1980

cttcggcgag tggaacgtga tccgcgacaa gtggaacgcc gagtacgacg acatccacct     2040

caagaagaag gcggtggtca ccgagaagta cgaggacgac aggcgcaagt ccttcaagaa     2100

gatcggctcc ttcagcctcg agcagctgca ggagtacgcc gacgcggacc tgagcgtggt     2160

cgagaagctc aaggagatca tcatccagaa ggtcgacgag atctacaagg tgtacggctc     2220

cagcgagaag ctcttcgacg cggacttcgt cctcgagaag tccctgaaga agaacgacgc     2280

cgtggtcgcg atcatgaagg acctcctgga ctccgtgaag agcttcgaga attacatcaa     2340

ggccttcttc ggcgagggca aggagacgaa cagggacgag tccttctacg gcgacttcgt     2400

cctggcctac gacatcctcc tgaaggtgga ccacatctac gacgcgatcc gcaactacgt     2460

gacccagaag ccgtacagca aggacaagtt caagctctac ttccagaacc cccagttcat     2520

gggcggctgg gacaaggaca aggagacgga ctacagggcg accatcctgc gctacggcag     2580

caagtactac ctcgccatca tggacaagaa gtacgcgaag tgcctgcaga agatcgacaa     2640

ggacgacgtc aacggcaact acgagaagat caactacaag ctcctgccgg gccccaacaa     2700

gatgctcccg aaggtgttct tctccaagaa gtggatggcc tactacaacc ccagcgagga     2760

catccagaag atctacaaga acggcacgtt caagaagggc gacatgttca acctgaacga     2820

ctgccacaag ctcatcgact tcttcaagga ctccatcagc cgctacccga agtggtccaa     2880

cgcctacgac ttcaacttca gcgagaccga gaagtacaag gacatcgcgg gcttctaccg     2940

cgaggtcgag gagcagggct acaaggtgtc cttcgagtcc gccagcaaga aggaggtcga     3000

caagctggtg gaggagggca agctctacat gttccagatc tacaacaagg acttctccga     3060

caagagccac ggcacgccca acctgcacac catgtacttc aagctcctgt tcgacgagaa     3120

caaccacggc cagatcaggc tgtccggcgg cgccgagctc ttcatgagga gggcgagcct     3180

gaagaaggag gagctggtgg tccaccccgc taacagccca atcgcgaaca agaacccgga     3240

caaccccaag aagaccacga ccctgtccta cgacgtgtac aaggacaaga ggttcagcga     3300

ggaccagtac gagctccaca tcccgatcgc gatcaacaag tgccccaaga acatcttcaa     3360

gatcaacacc gaggtccgcg tgctcctgaa gcacgacgac aacccctacg tgatcggcat     3420

cgctaggggc gagaggaacc tcctgtacat cgtggtcgtg gacggcaagg gcaacatcgt     3480

ggagcagtac tccctcaacg agatcatcaa caacttcaac ggcatcagga tcaagacgga     3540

ctaccacagc ctcctggaca agaaggagaa ggagaggttc gaggcccgcc agaactggac     3600

ctccatcgag aacatcaagg agctgaaggc gggctacatc agccaggtcg tgcacaagat     3660

ctgcgagctc gtcgagaagt acgacgccgt gatcgccctc gcggacctga actccggctt     3720

caagaacagc cgcgtcaagg tggagaagca ggtctaccag aagttcgaga agatgctcat     3780

cgacaagctg aactacatgg tggacaagaa gtccaacccc tgcgctacgg gcggcgcgct     3840

gaagggctac cagatcacca acaagttcga gagcttcaag tccatgagca ctcagaacgg     3900

cttcatcttc tacatcccgg cgtggctcac gtccaagatc gaccccagca ccggcttcgt     3960

caacctcctg aagacgaagt acacctccat cgccgacagc aagaagttca tctccagctt     4020

cgaccgcatc atgtatgtgc cggaggagga cctgttcgag ttcgccctcg actacaagaa     4080

cttctcccgc acggacgcgg actacatcaa gaagtggaag ctgtacagct acggcaaccg     4140

catccgcatc ttcaggaacc ccaagaagaa caacgtcttc gactgggagg aggtgtgcct     4200

gacctccgcg tacaaggagc tcttcaacaa gtacggcatc aactaccagc agggcgacat     4260

cagggctctc ctgtgcgagc agagcgacaa ggccttctac tccagcttca tggcgctgat     4320

gtccctcatg ctgcagatga ggaactcgat caccggcagg acggacgtgg ccttcctcat     4380

ctccccggtg aagaacagcg acggcatctt ctacgactcc aggaactacg aggcccagga     4440

gaacgcgatc ctcccaaaga acgcggacgc caacggcgcc tacaacatcg ccaggaaggt     4500

cctctgggct atcggccagt tcaagaaggc ggaggacgag aagctggaca aggtgaagat     4560

cgccatcagc aacaaggagt ggctcgagta cgcccagacc tcggtcaagc acggcagccc     4620

gaagaagaag cgcaaggtgt ccggcggcag cacgaacctg tccgacatca tcgagaagga     4680

gaccggcaag cagctcgtga tccaggagag catcctcatg ctgccggagg aggtcgagga     4740

ggtcatcggc aacaagcccg agtccgacat cctcgtccac acggcctacg acgagtccac     4800

cgacgagaac gtgatgctcc tgacctcgga cgctcccgag tacaagccat gggccctggt     4860

catccaggac agcaacggcg agaacaagat caagatgctc tccggcggca gcccgaagaa     4920

gaagcgcaaa gtgtga                                                     4936


<210>  83
<211>  1636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  83

Met Pro Lys Lys Lys Arg Lys Val Met Thr Asp Ala Glu Tyr Val Arg 
1               5                   10                  15      


Ile His Glu Lys Leu Asp Ile Tyr Thr Phe Lys Lys Gln Phe Phe Asn 
            20                  25                  30          


Asn Lys Lys Ser Val Ser His Arg Cys Tyr Val Leu Phe Glu Leu Lys 
        35                  40                  45              


Arg Arg Gly Glu Arg Arg Ala Cys Phe Trp Gly Tyr Ala Val Asn Lys 
    50                  55                  60                  


Pro Gln Ser Gly Thr Glu Arg Gly Ile His Ala Glu Ile Phe Ser Ile 
65                  70                  75                  80  


Arg Lys Val Glu Glu Tyr Leu Arg Asp Asn Pro Gly Gln Phe Thr Ile 
                85                  90                  95      


Asn Trp Tyr Ser Ser Trp Ser Pro Val Ser Phe Cys Phe Tyr Leu Tyr 
            100                 105                 110         


Ile Tyr Asn Asn Tyr His Leu Val Val Ile Tyr Phe Lys Tyr Phe Phe 
        115                 120                 125             


Gln Asn Lys Arg Met Tyr Ile Ala Ile Ala Phe Leu Phe Ile Ser Val 
    130                 135                 140                 


Tyr Ile Leu Ile Tyr Asn Phe Ser Asn Ile Pro Lys Phe Val Asp Val 
145                 150                 155                 160 


Gln Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu 
                165                 170                 175     


Leu Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr 
            180                 185                 190         


Tyr Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp 
        195                 200                 205             


Asn Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys 
    210                 215                 220                 


Arg Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg 
225                 230                 235                 240 


Trp Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu 
                245                 250                 255     


Ser Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala 
            260                 265                 270         


Val Gly Gly Arg Gly Leu Arg Arg Gly Arg Glu Arg Arg Arg Gly Leu 
        275                 280                 285             


Trp Gly Arg Arg Gln Arg Arg Gly Arg Gln Arg Gly Arg Arg Val Asp 
    290                 295                 300                 


Glu Gln Ala Gly Glu Val His Glu Leu Leu Leu Pro Gln Gln Asp Pro 
305                 310                 315                 320 


Glu Val Gln Gly Asp Pro Gly Arg Gln Asp Pro Gly Glu His Arg Gln 
                325                 330                 335     


Gln Ala Ala Ala Gly Gly Gly Arg Glu Glu Gly Gly Leu Gln Gly Arg 
            340                 345                 350         


Glu Glu Ala Pro Gly Pro Leu Leu Pro Val Leu His Gln Arg Arg Ala 
        355                 360                 365             


Pro Gln His Gln Ala Gln Glu Pro Glu Gln Leu His Gln Pro Leu Gln 
    370                 375                 380                 


Glu Glu Asp Ala His Arg Glu Gly Glu Gln Gly Ala Arg Glu Pro Gly 
385                 390                 395                 400 


Asp Gln Pro Glu Glu Gly Asp Arg Gln Gly Val Gln Gly Gln Arg Gly 
                405                 410                 415     


Leu Gln Val Pro Leu Gln Glu Gly His His Arg Asp Asp Pro Pro Gly 
            420                 425                 430         


Val Pro Gly Arg Gln Gly Arg Asp Arg Pro Gly Gln Leu Leu Gln Arg 
        435                 440                 445             


Leu His His Gly Val His Arg Leu Leu Arg Gln Pro Arg Glu His Val 
    450                 455                 460                 


Gln Arg Gly Gly Gln Val His Glu His Arg Val Gln Val His Gln Arg 
465                 470                 475                 480 


Glu Pro His Pro Leu His Leu Gln His Gly His Leu Arg Glu Gly Arg 
                485                 490                 495     


Arg Asp Leu Arg Gln Ala Arg Gly Ala Gly Asp Gln Gly Glu Asp Pro 
            500                 505                 510         


Glu Gln Arg Leu Arg Arg Arg Gly Leu Leu Arg Gly Arg Val Leu Gln 
        515                 520                 525             


Leu Arg Pro His Ala Gly Gly His Arg Arg Val Gln Arg His His Arg 
    530                 535                 540                 


Trp Leu Arg Asp Arg Val Arg Arg Glu Asp Gln Gly Pro Glu Arg Val 
545                 550                 555                 560 


His Gln Pro Leu Gln Pro Glu Asp Gln Ala Glu Ala Ala Glu Val Gln 
                565                 570                 575     


Ala Pro Val Gln Ala Gly Ala Leu Arg Gln Gly Val Pro Gln Leu Leu 
            580                 585                 590         


Arg Arg Gly Leu His Glu Arg Arg Gly Gly Pro Gly Gly Val Pro Gln 
        595                 600                 605             


His Pro Gln Gln Glu Gln Arg Asp Leu Leu Gln His Gln Glu Ala Arg 
    610                 615                 620                 


Glu Ala Val Gln Glu Leu Arg Arg Val Leu Gln Arg Arg His Leu Arg 
625                 630                 635                 640 


Gln Glu Arg Pro Gly Asp Leu His Asp Gln Gln Gly His Leu Arg Arg 
                645                 650                 655     


Val Glu Arg Asp Pro Arg Gln Val Glu Arg Arg Val Arg Arg His Pro 
            660                 665                 670         


Pro Gln Glu Glu Gly Gly Gly His Arg Glu Val Arg Gly Arg Gln Ala 
        675                 680                 685             


Gln Val Leu Gln Glu Asp Arg Leu Leu Gln Pro Arg Ala Ala Ala Gly 
    690                 695                 700                 


Val Arg Arg Arg Gly Pro Glu Arg Gly Arg Glu Ala Gln Gly Asp His 
705                 710                 715                 720 


His Pro Glu Gly Arg Arg Asp Leu Gln Gly Val Arg Leu Gln Arg Glu 
                725                 730                 735     


Ala Leu Arg Arg Gly Leu Arg Pro Arg Glu Val Pro Glu Glu Glu Arg 
            740                 745                 750         


Arg Arg Gly Arg Asp His Glu Gly Pro Pro Gly Leu Arg Glu Glu Leu 
        755                 760                 765             


Arg Glu Leu His Gln Gly Leu Leu Arg Arg Gly Gln Gly Asp Glu Gln 
    770                 775                 780                 


Gly Arg Val Leu Leu Arg Arg Leu Arg Pro Gly Leu Arg His Pro Pro 
785                 790                 795                 800 


Glu Gly Gly Pro His Leu Arg Arg Asp Pro Gln Leu Arg Asp Pro Glu 
                805                 810                 815     


Ala Val Gln Gln Gly Gln Val Gln Ala Leu Leu Pro Glu Pro Pro Val 
            820                 825                 830         


His Gly Arg Leu Gly Gln Gly Gln Gly Asp Gly Leu Gln Gly Asp His 
        835                 840                 845             


Pro Ala Leu Arg Gln Gln Val Leu Pro Arg His His Gly Gln Glu Val 
    850                 855                 860                 


Arg Glu Val Pro Ala Glu Asp Arg Gln Gly Arg Arg Gln Arg Gln Leu 
865                 870                 875                 880 


Arg Glu Asp Gln Leu Gln Ala Pro Ala Gly Pro Gln Gln Asp Ala Pro 
                885                 890                 895     


Glu Gly Val Leu Leu Gln Glu Val Asp Gly Leu Leu Gln Pro Gln Arg 
            900                 905                 910         


Gly His Pro Glu Asp Leu Gln Glu Arg His Val Gln Glu Gly Arg His 
        915                 920                 925             


Val Gln Pro Glu Arg Leu Pro Gln Ala His Arg Leu Leu Gln Gly Leu 
    930                 935                 940                 


His Gln Pro Leu Pro Glu Val Val Gln Arg Leu Arg Leu Gln Leu Gln 
945                 950                 955                 960 


Arg Asp Arg Glu Val Gln Gly His Arg Gly Leu Leu Pro Arg Gly Arg 
                965                 970                 975     


Gly Ala Gly Leu Gln Gly Val Leu Arg Val Arg Gln Gln Glu Gly Gly 
            980                 985                 990         


Arg Gln Ala Gly Gly Gly Gly Gln  Ala Leu His Val Pro  Asp Leu Gln 
        995                 1000                 1005             


Gln Gly  Leu Leu Arg Gln Glu  Pro Arg His Ala Gln  Pro Ala His 
    1010                 1015                 1020             


His Val  Leu Gln Ala Pro Val  Arg Arg Glu Gln Pro  Arg Pro Asp 
    1025                 1030                 1035             


Gln Ala  Val Arg Arg Arg Arg  Ala Leu His Glu Glu  Gly Glu Pro 
    1040                 1045                 1050             


Glu Glu  Gly Gly Ala Gly Gly  Pro Pro Arg Gln Pro  Asn Arg Glu 
    1055                 1060                 1065             


Gln Glu  Pro Gly Gln Pro Gln  Glu Asp His Asp Pro  Val Leu Arg 
    1070                 1075                 1080             


Arg Val  Gln Gly Gln Glu Val  Gln Arg Gly Pro Val  Arg Ala Pro 
    1085                 1090                 1095             


His Pro  Asp Arg Asp Gln Gln  Val Pro Gln Glu His  Leu Gln Asp 
    1100                 1105                 1110             


Gln His  Arg Gly Pro Arg Ala  Pro Glu Ala Arg Arg  Gln Pro Leu 
    1115                 1120                 1125             


Arg Asp  Arg His Arg Gly Arg  Glu Glu Pro Pro Val  His Arg Gly 
    1130                 1135                 1140             


Arg Gly  Arg Gln Gly Gln His  Arg Gly Ala Val Leu  Pro Gln Arg 
    1145                 1150                 1155             


Asp His  Gln Gln Leu Gln Arg  His Gln Asp Gln Asp  Gly Leu Pro 
    1160                 1165                 1170             


Gln Pro  Pro Gly Gln Glu Gly  Glu Gly Glu Val Arg  Gly Pro Pro 
    1175                 1180                 1185             


Glu Leu  Asp Leu His Arg Glu  His Gln Gly Ala Glu  Gly Gly Leu 
    1190                 1195                 1200             


His Gln  Pro Gly Arg Ala Gln  Asp Leu Arg Ala Arg  Arg Glu Val 
    1205                 1210                 1215             


Arg Arg  Arg Asp Arg Pro Arg  Gly Pro Glu Leu Arg  Leu Gln Glu 
    1220                 1225                 1230             


Gln Pro  Arg Gln Gly Gly Glu  Ala Gly Leu Pro Glu  Val Arg Glu 
    1235                 1240                 1245             


Asp Ala  His Arg Gln Ala Glu  Leu His Gly Gly Gln  Glu Val Gln 
    1250                 1255                 1260             


Pro Leu  Arg Tyr Gly Arg Arg  Ala Glu Gly Leu Pro  Asp His Gln 
    1265                 1270                 1275             


Gln Val  Arg Glu Leu Gln Val  His Glu His Ser Glu  Arg Leu His 
    1280                 1285                 1290             


Leu Leu  His Pro Gly Val Ala  His Val Gln Asp Arg  Pro Gln His 
    1295                 1300                 1305             


Arg Leu  Arg Gln Pro Pro Glu  Asp Glu Val His Leu  His Arg Arg 
    1310                 1315                 1320             


Gln Gln  Glu Val His Leu Gln  Leu Arg Pro His His  Val Cys Ala 
    1325                 1330                 1335             


Gly Gly  Gly Pro Val Arg Val  Arg Pro Arg Leu Gln  Glu Leu Leu 
    1340                 1345                 1350             


Pro His  Gly Arg Gly Leu His  Gln Glu Val Glu Ala  Val Gln Leu 
    1355                 1360                 1365             


Arg Gln  Pro His Pro His Leu  Gln Glu Pro Gln Glu  Glu Gln Arg 
    1370                 1375                 1380             


Leu Arg  Leu Gly Gly Gly Val  Pro Asp Leu Arg Val  Gln Gly Ala 
    1385                 1390                 1395             


Leu Gln  Gln Val Arg His Gln  Leu Pro Ala Gly Arg  His Gln Gly 
    1400                 1405                 1410             


Ser Pro  Val Arg Ala Glu Arg  Gln Gly Leu Leu Leu  Gln Leu His 
    1415                 1420                 1425             


Gly Ala  Asp Val Pro His Ala  Ala Asp Glu Glu Leu  Asp His Arg 
    1430                 1435                 1440             


Gln Asp  Gly Arg Gly Leu Pro  His Leu Pro Gly Glu  Glu Gln Arg 
    1445                 1450                 1455             


Arg His  Leu Leu Arg Leu Gln  Glu Leu Arg Gly Pro  Gly Glu Arg 
    1460                 1465                 1470             


Asp Pro  Pro Lys Glu Arg Gly  Arg Gln Arg Arg Leu  Gln His Arg 
    1475                 1480                 1485             


Gln Glu  Gly Pro Leu Gly Tyr  Arg Pro Val Gln Glu  Gly Gly Gly 
    1490                 1495                 1500             


Arg Glu  Ala Gly Gln Gly Glu  Asp Arg His Gln Gln  Gln Gly Val 
    1505                 1510                 1515             


Ala Arg  Val Arg Pro Asp Leu  Gly Gln Ala Arg Gln  Pro Glu Glu 
    1520                 1525                 1530             


Glu Ala  Gln Gly Val Arg Arg  Gln His Glu Pro Val  Arg His His 
    1535                 1540                 1545             


Arg Glu  Gly Asp Arg Gln Ala  Ala Arg Asp Pro Gly  Glu His Pro 
    1550                 1555                 1560             


His Ala  Ala Gly Gly Gly Arg  Gly Gly His Arg Gln  Gln Ala Arg 
    1565                 1570                 1575             


Val Arg  His Pro Arg Pro His  Gly Leu Arg Arg Val  His Arg Arg 
    1580                 1585                 1590             


Glu Arg  Asp Ala Pro Asp Leu  Gly Arg Ser Arg Val  Gln Ala Met 
    1595                 1600                 1605             


Gly Pro  Gly His Pro Gly Gln  Gln Arg Arg Glu Gln  Asp Gln Asp 
    1610                 1615                 1620             


Ala Leu  Arg Arg Gln Pro Glu  Glu Glu Ala Gln Ser  Val 
    1625                 1630                 1635     


<210>  84
<211>  6210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
atgtccgagg tggagttcag ccacgagtac tggatgaggc acgctctcac cctggctaag       60

agggcgtggg acgagaggga ggtgccggtg ggcgccgtgc tcgtccacaa caaccgcgtg      120

atcggcgagg gctggaacag gcccatcggc aggcacgacc caaccgctca cgccgagatc      180

atggctctca ggcagggcgg cctggtcatg cagaactaca ggctgatcga cgcgaccctc      240

tacgtgaccc tcgagccctg cgtcatggta agtttctgct tctacctttg atatatatat      300

aataattatc attaattagt agtaatataa tatttcaaat atttttttca aaataaaaga      360

atgtagtata tagcaattgc ttttctgtag tttataagtg tgtatatttt aatttataac      420

ttttctaata tatgaccaaa atttgttgat gtgcagtgcg cgggcgccat gatccactcc      480

aggatcggca gggtggtctt cggcgctagg gacgccaaga cgggcgctgc gggcagcctc      540

atggacgtgc tgcaccaccc cggcatgaac caccgcgtcg agatcaccga gggcatcctc      600

gcggacgagt gcgctgcgct cctgtccgac ttcttcagga tgcgcaggca ggagatcaag      660

gcccagaaga aggcgcagtc cagcaccgac tccggcggct ccagcggcgg ctccagcggc      720

agcgagaccc cgggcacgtc cgagagcgcg acgcccgaga gcagcggcgg ctccagcggc      780

ggctcctcgg aggtcgagtt cagccatgag tactggatga ggcatgccct gactctcgct      840

aagagggcgc gggatgagcg cgaggtgccg gtgggggccg tgctcgtcct gaacaaccgc      900

gtgatcgggg agggctggaa ccgggctatc ggcctccacg acccaacggc ccatgccgag      960

atcatggccc tgaggcaggg cggcctggtc atgcaaaact acaggctcat cgacgccacc     1020

ctctacgtga ccttcgagcc atgcgtgatg tgcgcggggg ccatgatcca ctcgaggatt     1080

gggagggtgg tcttcggcgt gcgcaacgct aagacggggg ccgccggcag cctcatggac     1140

gtcctgcact acccgggcat gaaccacagg gtggagatta ccgagggcat cctggccgat     1200

gagtgcgccg cgctcctgtg ctacttcttc cgcatgccca ggcaggtctt caacgcgcag     1260

aagaaggccc agagctccac tgatgggggc gggggctcag gcgggggcgg gagcggcggc     1320

gggggctctg ggggcggcgg cagcggcggg ggcggcagcg ggggcggcgg gtcgatgagc     1380

aagctggaga agttcacgaa ctgctactcc ctcagcaaga ccctgaggtt caaggcgatc     1440

ccggtcggca agacccagga gaacatcgac aacaagcggc tgctggtgga ggacgagaag     1500

agggctgagg actacaaggg cgtgaagaag ctcctggacc gctactacct gtccttcatc     1560

aacgacgtgc tccacagcat caagctcaag aacctgaaca actacatcag cctcttcagg     1620

aagaagacgc gcaccgagaa ggagaacaag gagctcgaga acctggagat caacctgagg     1680

aaggagatcg ccaaggcgtt caagggcaac gagggctaca agtccctctt caagaaggac     1740

atcatcgaga cgatcctccc ggagttcctg gacgacaagg acgagatcgc cctggtcaac     1800

tccttcaacg gcttcaccac ggcgttcacc ggcttcttcg acaaccgcga gaacatgttc     1860

agcgaggagg ccaagtccac gagcatcgcg ttcaggtgca tcaacgagaa cctcacccgc     1920

tacatctcca acatggacat cttcgagaag gtcgacgcga tcttcgacaa gcacgaggtg     1980

caggagatca aggagaagat cctgaacagc gactacgacg tcgaggactt cttcgagggc     2040

gagttcttca acttcgtcct cacgcaggag ggcatcgacg tgtacaacgc catcatcggt     2100

ggcttcgtga ccgagtccgg cgagaagatc aagggcctga acgagtacat caacctctac     2160

aaccagaaga ccaagcagaa gctgccgaag ttcaagcccc tgtacaagca ggtgctctcc     2220

gacagggagt ccctcagctt ctacggcgag ggctacacga gcgacgagga ggtcctggag     2280

gtgttccgca acaccctcaa caagaacagc gagatcttct ccagcatcaa gaagctcgag     2340

aagctgttca agaacttcga cgagtactcc agcgccggca tcttcgtcaa gaacggcccg     2400

gcgatctcca cgatcagcaa ggacatcttc ggcgagtgga acgtgatccg cgacaagtgg     2460

aacgccgagt acgacgacat ccacctcaag aagaaggcgg tggtcaccga gaagtacgag     2520

gacgacaggc gcaagtcctt caagaagatc ggctccttca gcctcgagca gctgcaggag     2580

tacgccgacg cggacctgag cgtggtcgag aagctcaagg agatcatcat ccagaaggtc     2640

gacgagatct acaaggtgta cggctccagc gagaagctct tcgacgcgga cttcgtcctc     2700

gagaagtccc tgaagaagaa cgacgccgtg gtcgcgatca tgaaggacct cctggactcc     2760

gtgaagagct tcgagaatta catcaaggcc ttcttcggcg agggcaagga gacgaacagg     2820

gacgagtcct tctacggcga cttcgtcctg gcctacgaca tcctcctgaa ggtggaccac     2880

atctacgacg cgatccgcaa ctacgtgacc cagaagccgt acagcaagga caagttcaag     2940

ctctacttcc agaaccccca gttcatgggc ggctgggaca aggacaagga gacggactac     3000

agggcgacca tcctgcgcta cggcagcaag tactacctcg ccatcatgga caagaagtac     3060

gcgaagtgcc tgcagaagat cgacaaggac gacgtcaacg gcaactacga gaagatcaac     3120

tacaagctcc tgccgggccc caacaagatg ctcccgaagg tgttcttctc caagaagtgg     3180

atggcctact acaaccccag cgaggacatc cagaagatct acaagaacgg cacgttcaag     3240

aagggcgaca tgttcaacct gaacgactgc cacaagctca tcgacttctt caaggactcc     3300

atcagccgct acccgaagtg gtccaacgcc tacgacttca acttcagcga gaccgagaag     3360

tacaaggaca tcgcgggctt ctaccgcgag gtcgaggagc agggctacaa ggtgtccttc     3420

gagtccgcca gcaagaagga ggtcgacaag ctggtggagg agggcaagct ctacatgttc     3480

cagatctaca acaaggactt ctccgacaag agccacggca cgcccaacct gcacaccatg     3540

tacttcaagc tcctgttcga cgagaacaac cacggccaga tcaggctgtc cggcggcgcc     3600

gagctcttca tgaggagggc gagcctgaag aaggaggagc tggtggtcca ccccgctaac     3660

agcccaatcg cgaacaagaa cccggacaac cccaagaaga ccacgaccct gtcctacgac     3720

gtgtacaagg acaagaggtt cagcgaggac cagtacgagc tccacatccc gatcgcgatc     3780

aacaagtgcc ccaagaacat cttcaagatc aacaccgagg tccgcgtgct cctgaagcac     3840

gacgacaacc cctacgtgat cggcatcgct aggggcgaga ggaacctcct gtacatcgtg     3900

gtcgtggacg gcaagggcaa catcgtggag cagtactccc tcaacgagat catcaacaac     3960

ttcaacggca tcaggatcaa gacggactac cacagcctcc tggacaagaa ggagaaggag     4020

aggttcgagg cccgccagaa ctggacctcc atcgagaaca tcaaggagct gaaggcgggc     4080

tacatcagcc aggtcgtgca caagatctgc gagctcgtcg agaagtacga cgccgtgatc     4140

gccctcgcgg acctgaactc cggcttcaag aacagccgcg tcaaggtgga gaagcaggtc     4200

taccagaagt tcgagaagat gctcatcgac aagctgaact acatggtgga caagaagtcc     4260

aacccctgcg ctacgggcgg cgcgctgaag ggctaccaga tcaccaacaa gttcgagagc     4320

ttcaagtcca tgagcactca gaacggcttc atcttctaca tcccggcgtg gctcacgtcc     4380

aagatcgacc ccagcaccgg cttcgtcaac ctcctgaaga cgaagtacac ctccatcgcc     4440

gacagcaaga agttcatctc cagcttcgac cgcatcatgt atgtgccgga ggaggacctg     4500

ttcgagttcg ccctcgacta caagaacttc tcccgcacgg acgcggacta catcaagaag     4560

tggaagctgt acagctacgg caaccgcatc cgcatcttca ggaaccccaa gaagaacaac     4620

gtcttcgact gggaggaggt gtgcctgacc tccgcgtaca aggagctctt caacaagtac     4680

ggcatcaact accagcaggg cgacatcagg gctctcctgt gcgagcagag cgacaaggcc     4740

ttctactcca gcttcatggc gctgatgtcc ctcatgctgc agatgaggaa ctcgatcacc     4800

ggcaggacgg acgtggcctt cctcatctcc ccggtgaaga acagcgacgg catcttctac     4860

gactccagga actacgaggc ccaggagaac gcgatcctcc caaagaacgc ggacgccaac     4920

ggcgcctaca acatcgccag gaaggtcctc tgggctatcg gccagttcaa gaaggcggag     4980

gacgagaagc tggacaaggt gaagatcgcc atcagcaaca aggagtggct cgagtacgcc     5040

cagacctcgg tcaagcacgg cagcccgaag aagaagcgca aggtgggcag cgcggagtac     5100

gttcgggctc tgttcgactt caacggcaac gacgaggagg acctcccgtt caagaagggc     5160

gacatcctgc gcatcaggga caagccggag gagcagtggt ggaacgccga ggactccgag     5220

ggcaagaggg gcatgatccc ggtcccctac gtggagaagt acatgaccga cgcggagtat     5280

gtgcgcatcc acgagaagct cgacatctac accttcaaga agcagttctt caacaacaag     5340

aagagcgtct cccacaggtg ctacgtgctc ttcgagctga agaggcgcgg cgagcgcagg     5400

gcctgcttct ggggctacgc cgtgaacaag ccgcagagcg gcaccgagcg cggcatccac     5460

gccgagatct tcagcatccg caaggtggag gagtacctca gggacaaccc gggccagttc     5520

accatcaact ggtacagctc ctggagcccg tgcgcggact gcgccgagaa gatcctggag     5580

tggtacaacc aggagctgag gggcaacggc cacaccctga agatctgggc ctgcaagctc     5640

tactacgaga agaacgcgag gaaccagatc ggcctgtgga acctccgcga caacggcgtc     5700

ggcctcaacg tgatggtctc cgagcactac cagtgctgcc gcaagatctt catccagtcc     5760

agccacaacc agctcaacga gaacaggtgg ctggagaaga ccctgaagag ggccgagaag     5820

cgcaggtccg agctcagcat catgatccag gtgaagatcc tccacaccac gaagtccccc     5880

gccgtgggca gcccgaagaa gaagcgcaag gtgtccggcg gcagcacgaa cctgtccgac     5940

atcatcgaga aggagaccgg caagcagctc gtgatccagg agagcatcct catgctgccg     6000

gaggaggtcg aggaggtcat cggcaacaag cccgagtccg acatcctcgt ccacacggcc     6060

tacgacgagt ccaccgacga gaacgtgatg ctcctgacct cggacgctcc cgagtacaag     6120

ccatgggccc tggtcatcca ggacagcaac ggcgagaaca agatcaagat gctctccggc     6180

ggcagcccga agaagaagcg caaagtgtga                                      6210


<210>  85
<211>  2063
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  85

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Val Ser Phe Cys Phe Tyr Leu 
                85                  90                  95      


Tyr Ile Tyr Asn Asn Tyr His Leu Val Val Ile Tyr Phe Lys Tyr Phe 
            100                 105                 110         


Phe Gln Asn Lys Arg Met Tyr Ile Ala Ile Ala Phe Leu Phe Ile Ser 
        115                 120                 125             


Val Tyr Ile Leu Ile Tyr Asn Phe Ser Asn Ile Pro Lys Phe Val Asp 
    130                 135                 140                 


Val Gln Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val 
145                 150                 155                 160 


Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp 
                165                 170                 175     


Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly 
            180                 185                 190         


Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe Arg Met 
        195                 200                 205             


Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp 
    210                 215                 220                 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
225                 230                 235                 240 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
            260                 265                 270         


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
        275                 280                 285             


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
    290                 295                 300                 


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
305                 310                 315                 320 


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
                325                 330                 335     


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
            340                 345                 350         


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
        355                 360                 365             


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
    370                 375                 380                 


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
385                 390                 395                 400 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
                405                 410                 415     


Ala Gln Ser Ser Thr Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser 
    450                 455                 460                 


Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln 
465                 470                 475                 480 


Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala 
                485                 490                 495     


Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser 
            500                 505                 510         


Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn 
        515                 520                 525             


Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys 
    530                 535                 540                 


Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala 
545                 550                 555                 560 


Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile 
                565                 570                 575     


Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu 
            580                 585                 590         


Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp 
        595                 600                 605             


Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala 
    610                 615                 620                 


Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp 
625                 630                 635                 640 


Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu 
                645                 650                 655     


Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe 
            660                 665                 670         


Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val 
        675                 680                 685             


Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile 
    690                 695                 700                 


Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln 
705                 710                 715                 720 


Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg 
                725                 730                 735     


Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val 
            740                 745                 750         


Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser 
        755                 760                 765             


Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser 
    770                 775                 780                 


Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser 
785                 790                 795                 800 


Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala 
                805                 810                 815     


Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys 
            820                 825                 830         


Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser 
        835                 840                 845             


Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu 
    850                 855                 860                 


Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val 
865                 870                 875                 880 


Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys 
                885                 890                 895     


Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu 
            900                 905                 910         


Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu 
        915                 920                 925             


Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu 
    930                 935                 940                 


Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg 
945                 950                 955                 960 


Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr 
                965                 970                 975     


Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr 
            980                 985                 990         


Asp Tyr Arg Ala Thr Ile Leu Arg  Tyr Gly Ser Lys Tyr  Tyr Leu Ala 
        995                 1000                 1005             


Ile Met  Asp Lys Lys Tyr Ala  Lys Cys Leu Gln Lys  Ile Asp Lys 
    1010                 1015                 1020             


Asp Asp  Val Asn Gly Asn Tyr  Glu Lys Ile Asn Tyr  Lys Leu Leu 
    1025                 1030                 1035             


Pro Gly  Pro Asn Lys Met Leu  Pro Lys Val Phe Phe  Ser Lys Lys 
    1040                 1045                 1050             


Trp Met  Ala Tyr Tyr Asn Pro  Ser Glu Asp Ile Gln  Lys Ile Tyr 
    1055                 1060                 1065             


Lys Asn  Gly Thr Phe Lys Lys  Gly Asp Met Phe Asn  Leu Asn Asp 
    1070                 1075                 1080             


Cys His  Lys Leu Ile Asp Phe  Phe Lys Asp Ser Ile  Ser Arg Tyr 
    1085                 1090                 1095             


Pro Lys  Trp Ser Asn Ala Tyr  Asp Phe Asn Phe Ser  Glu Thr Glu 
    1100                 1105                 1110             


Lys Tyr  Lys Asp Ile Ala Gly  Phe Tyr Arg Glu Val  Glu Glu Gln 
    1115                 1120                 1125             


Gly Tyr  Lys Val Ser Phe Glu  Ser Ala Ser Lys Lys  Glu Val Asp 
    1130                 1135                 1140             


Lys Leu  Val Glu Glu Gly Lys  Leu Tyr Met Phe Gln  Ile Tyr Asn 
    1145                 1150                 1155             


Lys Asp  Phe Ser Asp Lys Ser  His Gly Thr Pro Asn  Leu His Thr 
    1160                 1165                 1170             


Met Tyr  Phe Lys Leu Leu Phe  Asp Glu Asn Asn His  Gly Gln Ile 
    1175                 1180                 1185             


Arg Leu  Ser Gly Gly Ala Glu  Leu Phe Met Arg Arg  Ala Ser Leu 
    1190                 1195                 1200             


Lys Lys  Glu Glu Leu Val Val  His Pro Ala Asn Ser  Pro Ile Ala 
    1205                 1210                 1215             


Asn Lys  Asn Pro Asp Asn Pro  Lys Lys Thr Thr Thr  Leu Ser Tyr 
    1220                 1225                 1230             


Asp Val  Tyr Lys Asp Lys Arg  Phe Ser Glu Asp Gln  Tyr Glu Leu 
    1235                 1240                 1245             


His Ile  Pro Ile Ala Ile Asn  Lys Cys Pro Lys Asn  Ile Phe Lys 
    1250                 1255                 1260             


Ile Asn  Thr Glu Val Arg Val  Leu Leu Lys His Asp  Asp Asn Pro 
    1265                 1270                 1275             


Tyr Val  Ile Gly Ile Ala Arg  Gly Glu Arg Asn Leu  Leu Tyr Ile 
    1280                 1285                 1290             


Val Val  Val Asp Gly Lys Gly  Asn Ile Val Glu Gln  Tyr Ser Leu 
    1295                 1300                 1305             


Asn Glu  Ile Ile Asn Asn Phe  Asn Gly Ile Arg Ile  Lys Thr Asp 
    1310                 1315                 1320             


Tyr His  Ser Leu Leu Asp Lys  Lys Glu Lys Glu Arg  Phe Glu Ala 
    1325                 1330                 1335             


Arg Gln  Asn Trp Thr Ser Ile  Glu Asn Ile Lys Glu  Leu Lys Ala 
    1340                 1345                 1350             


Gly Tyr  Ile Ser Gln Val Val  His Lys Ile Cys Glu  Leu Val Glu 
    1355                 1360                 1365             


Lys Tyr  Asp Ala Val Ile Ala  Leu Ala Asp Leu Asn  Ser Gly Phe 
    1370                 1375                 1380             


Lys Asn  Ser Arg Val Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe 
    1385                 1390                 1395             


Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys 
    1400                 1405                 1410             


Ser Asn  Pro Cys Ala Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile 
    1415                 1420                 1425             


Thr Asn  Lys Phe Glu Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly 
    1430                 1435                 1440             


Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro 
    1445                 1450                 1455             


Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile 
    1460                 1465                 1470             


Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr 
    1475                 1480                 1485             


Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn 
    1490                 1495                 1500             


Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr 
    1505                 1510                 1515             


Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn 
    1520                 1525                 1530             


Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys 
    1535                 1540                 1545             


Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile 
    1550                 1555                 1560             


Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser 
    1565                 1570                 1575             


Phe Met  Ala Leu Met Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile 
    1580                 1585                 1590             


Thr Gly  Arg Thr Asp Val Ala  Phe Leu Ile Ser Pro  Val Lys Asn 
    1595                 1600                 1605             


Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu 
    1610                 1615                 1620             


Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1625                 1630                 1635             


Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala 
    1640                 1645                 1650             


Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys 
    1655                 1660                 1665             


Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val Lys His  Gly Ser Pro 
    1670                 1675                 1680             


Lys Lys  Lys Arg Lys Val Gly  Ser Ala Glu Tyr Val  Arg Ala Leu 
    1685                 1690                 1695             


Phe Asp  Phe Asn Gly Asn Asp  Glu Glu Asp Leu Pro  Phe Lys Lys 
    1700                 1705                 1710             


Gly Asp  Ile Leu Arg Ile Arg  Asp Lys Pro Glu Glu  Gln Trp Trp 
    1715                 1720                 1725             


Asn Ala  Glu Asp Ser Glu Gly  Lys Arg Gly Met Ile  Pro Val Pro 
    1730                 1735                 1740             


Tyr Val  Glu Lys Tyr Met Thr  Asp Ala Glu Tyr Val  Arg Ile His 
    1745                 1750                 1755             


Glu Lys  Leu Asp Ile Tyr Thr  Phe Lys Lys Gln Phe  Phe Asn Asn 
    1760                 1765                 1770             


Lys Lys  Ser Val Ser His Arg  Cys Tyr Val Leu Phe  Glu Leu Lys 
    1775                 1780                 1785             


Arg Arg  Gly Glu Arg Arg Ala  Cys Phe Trp Gly Tyr  Ala Val Asn 
    1790                 1795                 1800             


Lys Pro  Gln Ser Gly Thr Glu  Arg Gly Ile His Ala  Glu Ile Phe 
    1805                 1810                 1815             


Ser Ile  Arg Lys Val Glu Glu  Tyr Leu Arg Asp Asn  Pro Gly Gln 
    1820                 1825                 1830             


Phe Thr  Ile Asn Trp Tyr Ser  Ser Trp Ser Pro Cys  Ala Asp Cys 
    1835                 1840                 1845             


Ala Glu  Lys Ile Leu Glu Trp  Tyr Asn Gln Glu Leu  Arg Gly Asn 
    1850                 1855                 1860             


Gly His  Thr Leu Lys Ile Trp  Ala Cys Lys Leu Tyr  Tyr Glu Lys 
    1865                 1870                 1875             


Asn Ala  Arg Asn Gln Ile Gly  Leu Trp Asn Leu Arg  Asp Asn Gly 
    1880                 1885                 1890             


Val Gly  Leu Asn Val Met Val  Ser Glu His Tyr Gln  Cys Cys Arg 
    1895                 1900                 1905             


Lys Ile  Phe Ile Gln Ser Ser  His Asn Gln Leu Asn  Glu Asn Arg 
    1910                 1915                 1920             


Trp Leu  Glu Lys Thr Leu Lys  Arg Ala Glu Lys Arg  Arg Ser Glu 
    1925                 1930                 1935             


Leu Ser  Ile Met Ile Gln Val  Lys Ile Leu His Thr  Thr Lys Ser 
    1940                 1945                 1950             


Pro Ala  Val Gly Ser Pro Lys  Lys Lys Arg Lys Val  Ser Gly Gly 
    1955                 1960                 1965             


Ser Thr  Asn Leu Ser Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln 
    1970                 1975                 1980             


Leu Val  Ile Gln Glu Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu 
    1985                 1990                 1995             


Glu Val  Ile Gly Asn Lys Pro  Glu Ser Asp Ile Leu  Val His Thr 
    2000                 2005                 2010             


Ala Tyr  Asp Glu Ser Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser 
    2015                 2020                 2025             


Asp Ala  Pro Glu Tyr Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser 
    2030                 2035                 2040             


Asn Gly  Glu Asn Lys Ile Lys  Met Leu Ser Gly Gly  Ser Pro Lys 
    2045                 2050                 2055             


Lys Lys  Arg Lys Val 
    2060             


<210>  86
<211>  6201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
atgccgaaga agaagcgcaa ggtcatgacc gacgcggagt atgtgcgcat ccacgagaag       60

ctcgacatct acaccttcaa gaagcagttc ttcaacaaca agaagagcgt ctcccacagg      120

tgctacgtgc tcttcgagct gaagaggcgc ggcgagcgca gggcctgctt ctggggctac      180

gccgtgaaca agccgcagag cggcaccgag cgcggcatcc acgccgagat cttcagcatc      240

cgcaaggtgg aggagtacct cagggacaac ccgggccagt tcaccatcaa ctggtacagc      300

tcctggagcc cggtaagttt ctgcttctac ctttgatata tatataataa ttatcattaa      360

ttagtagtaa tataatattt caaatatttt tttcaaaata aaagaatgta gtatatagca      420

attgcttttc tgtagtttat aagtgtgtat attttaattt ataacttttc taatatatga      480

ccaaaatttg ttgatgtgca gtgcgcggac tgcgccgaga agatcctgga gtggtacaac      540

caggagctga ggggcaacgg ccacaccctg aagatctggg cctgcaagct ctactacgag      600

aagaacgcga ggaaccagat cggcctgtgg aacctccgcg acaacggcgt cggcctcaac      660

gtgatggtct ccgagcacta ccagtgctgc cgcaagatct tcatccagtc cagccacaac      720

cagctcaacg agaacaggtg gctggagaag accctgaaga gggccgagaa gcgcaggtcc      780

gagctcagca tcatgatcca ggtgaagatc ctccacacca cgaagtcccc cgccgtggcg      840

gagtacgttc gggctctgtt cgacttcaac ggcaacgacg aggaggacct cccgttcaag      900

aagggcgaca tcctgcgcat cagggacaag ccggaggagc agtggtggaa cgccgaggac      960

tccgagggca agaggggcat gatcccggtc ccctacgtgg agaagtacat gtccgaggtg     1020

gagttcagcc acgagtactg gatgaggcac gctctcaccc tggctaagag ggcgtgggac     1080

gagagggagg tgccggtggg cgccgtgctc gtccacaaca accgcgtgat cggcgagggc     1140

tggaacaggc ccatcggcag gcacgaccca accgctcacg ccgagatcat ggctctcagg     1200

cagggcggcc tggtcatgca gaactacagg ctgatcgacg cgaccctcta cgtgaccctc     1260

gagccctgcg tcatgtgcgc gggcgccatg atccactcca ggatcggcag ggtggtcttc     1320

ggcgctaggg acgccaagac gggcgctgcg ggcagcctca tggacgtgct gcaccacccc     1380

ggcatgaacc accgcgtcga gatcaccgag ggcatcctcg cggacgagtg cgctgcgctc     1440

ctgtccgact tcttcaggat gcgcaggcag gagatcaagg cccagaagaa ggcgcagtcc     1500

agcaccgact ccggcggctc cagcggcggc tccagcggca gcgagacccc gggcacgtcc     1560

gagagcgcga cgcccgagag cagcggcggc tccagcggcg gctcctcgga ggtcgagttc     1620

agccatgagt actggatgag gcatgccctg actctcgcta agagggcgcg ggatgagcgc     1680

gaggtgccgg tgggggccgt gctcgtcctg aacaaccgcg tgatcgggga gggctggaac     1740

cgggctatcg gcctccacga cccaacggcc catgccgaga tcatggccct gaggcagggc     1800

ggcctggtca tgcaaaacta caggctcatc gacgccaccc tctacgtgac cttcgagcca     1860

tgcgtgatgt gcgcgggggc catgatccac tcgaggattg ggagggtggt cttcggcgtg     1920

cgcaacgcta agacgggggc cgccggcagc ctcatggacg tcctgcacta cccgggcatg     1980

aaccacaggg tggagattac cgagggcatc ctggccgatg agtgcgccgc gctcctgtgc     2040

tacttcttcc gcatgcccag gcaggtcttc aacgcgcaga agaaggccca gagctccact     2100

gatgggggcg ggggctcagg cgggggcggg agcggcggcg ggggctctgg gggcggcggc     2160

agcggcgggg gcggcagcgg gggcggcggg tcgatgagca agctggagaa gttcacgaac     2220

tgctactccc tcagcaagac cctgaggttc aaggcgatcc cggtcggcaa gacccaggag     2280

aacatcgaca acaagcggct gctggtggag gacgagaaga gggctgagga ctacaagggc     2340

gtgaagaagc tcctggaccg ctactacctg tccttcatca acgacgtgct ccacagcatc     2400

aagctcaaga acctgaacaa ctacatcagc ctcttcagga agaagacgcg caccgagaag     2460

gagaacaagg agctcgagaa cctggagatc aacctgagga aggagatcgc caaggcgttc     2520

aagggcaacg agggctacaa gtccctcttc aagaaggaca tcatcgagac gatcctcccg     2580

gagttcctgg acgacaagga cgagatcgcc ctggtcaact ccttcaacgg cttcaccacg     2640

gcgttcaccg gcttcttcga caaccgcgag aacatgttca gcgaggaggc caagtccacg     2700

agcatcgcgt tcaggtgcat caacgagaac ctcacccgct acatctccaa catggacatc     2760

ttcgagaagg tcgacgcgat cttcgacaag cacgaggtgc aggagatcaa ggagaagatc     2820

ctgaacagcg actacgacgt cgaggacttc ttcgagggcg agttcttcaa cttcgtcctc     2880

acgcaggagg gcatcgacgt gtacaacgcc atcatcggtg gcttcgtgac cgagtccggc     2940

gagaagatca agggcctgaa cgagtacatc aacctctaca accagaagac caagcagaag     3000

ctgccgaagt tcaagcccct gtacaagcag gtgctctccg acagggagtc cctcagcttc     3060

tacggcgagg gctacacgag cgacgaggag gtcctggagg tgttccgcaa caccctcaac     3120

aagaacagcg agatcttctc cagcatcaag aagctcgaga agctgttcaa gaacttcgac     3180

gagtactcca gcgccggcat cttcgtcaag aacggcccgg cgatctccac gatcagcaag     3240

gacatcttcg gcgagtggaa cgtgatccgc gacaagtgga acgccgagta cgacgacatc     3300

cacctcaaga agaaggcggt ggtcaccgag aagtacgagg acgacaggcg caagtccttc     3360

aagaagatcg gctccttcag cctcgagcag ctgcaggagt acgccgacgc ggacctgagc     3420

gtggtcgaga agctcaagga gatcatcatc cagaaggtcg acgagatcta caaggtgtac     3480

ggctccagcg agaagctctt cgacgcggac ttcgtcctcg agaagtccct gaagaagaac     3540

gacgccgtgg tcgcgatcat gaaggacctc ctggactccg tgaagagctt cgagaattac     3600

atcaaggcct tcttcggcga gggcaaggag acgaacaggg acgagtcctt ctacggcgac     3660

ttcgtcctgg cctacgacat cctcctgaag gtggaccaca tctacgacgc gatccgcaac     3720

tacgtgaccc agaagccgta cagcaaggac aagttcaagc tctacttcca gaacccccag     3780

ttcatgggcg gctgggacaa ggacaaggag acggactaca gggcgaccat cctgcgctac     3840

ggcagcaagt actacctcgc catcatggac aagaagtacg cgaagtgcct gcagaagatc     3900

gacaaggacg acgtcaacgg caactacgag aagatcaact acaagctcct gccgggcccc     3960

aacaagatgc tcccgaaggt gttcttctcc aagaagtgga tggcctacta caaccccagc     4020

gaggacatcc agaagatcta caagaacggc acgttcaaga agggcgacat gttcaacctg     4080

aacgactgcc acaagctcat cgacttcttc aaggactcca tcagccgcta cccgaagtgg     4140

tccaacgcct acgacttcaa cttcagcgag accgagaagt acaaggacat cgcgggcttc     4200

taccgcgagg tcgaggagca gggctacaag gtgtccttcg agtccgccag caagaaggag     4260

gtcgacaagc tggtggagga gggcaagctc tacatgttcc agatctacaa caaggacttc     4320

tccgacaaga gccacggcac gcccaacctg cacaccatgt acttcaagct cctgttcgac     4380

gagaacaacc acggccagat caggctgtcc ggcggcgccg agctcttcat gaggagggcg     4440

agcctgaaga aggaggagct ggtggtccac cccgctaaca gcccaatcgc gaacaagaac     4500

ccggacaacc ccaagaagac cacgaccctg tcctacgacg tgtacaagga caagaggttc     4560

agcgaggacc agtacgagct ccacatcccg atcgcgatca acaagtgccc caagaacatc     4620

ttcaagatca acaccgaggt ccgcgtgctc ctgaagcacg acgacaaccc ctacgtgatc     4680

ggcatcgcta ggggcgagag gaacctcctg tacatcgtgg tcgtggacgg caagggcaac     4740

atcgtggagc agtactccct caacgagatc atcaacaact tcaacggcat caggatcaag     4800

acggactacc acagcctcct ggacaagaag gagaaggaga ggttcgaggc ccgccagaac     4860

tggacctcca tcgagaacat caaggagctg aaggcgggct acatcagcca ggtcgtgcac     4920

aagatctgcg agctcgtcga gaagtacgac gccgtgatcg ccctcgcgga cctgaactcc     4980

ggcttcaaga acagccgcgt caaggtggag aagcaggtct accagaagtt cgagaagatg     5040

ctcatcgaca agctgaacta catggtggac aagaagtcca acccctgcgc tacgggcggc     5100

gcgctgaagg gctaccagat caccaacaag ttcgagagct tcaagtccat gagcactcag     5160

aacggcttca tcttctacat cccggcgtgg ctcacgtcca agatcgaccc cagcaccggc     5220

ttcgtcaacc tcctgaagac gaagtacacc tccatcgccg acagcaagaa gttcatctcc     5280

agcttcgacc gcatcatgta tgtgccggag gaggacctgt tcgagttcgc cctcgactac     5340

aagaacttct cccgcacgga cgcggactac atcaagaagt ggaagctgta cagctacggc     5400

aaccgcatcc gcatcttcag gaaccccaag aagaacaacg tcttcgactg ggaggaggtg     5460

tgcctgacct ccgcgtacaa ggagctcttc aacaagtacg gcatcaacta ccagcagggc     5520

gacatcaggg ctctcctgtg cgagcagagc gacaaggcct tctactccag cttcatggcg     5580

ctgatgtccc tcatgctgca gatgaggaac tcgatcaccg gcaggacgga cgtggccttc     5640

ctcatctccc cggtgaagaa cagcgacggc atcttctacg actccaggaa ctacgaggcc     5700

caggagaacg cgatcctccc aaagaacgcg gacgccaacg gcgcctacaa catcgccagg     5760

aaggtcctct gggctatcgg ccagttcaag aaggcggagg acgagaagct ggacaaggtg     5820

aagatcgcca tcagcaacaa ggagtggctc gagtacgccc agacctcggt caagcacggc     5880

agcccgaaga agaagcgcaa ggtgtccggc ggcagcacga acctgtccga catcatcgag     5940

aaggagaccg gcaagcagct cgtgatccag gagagcatcc tcatgctgcc ggaggaggtc     6000

gaggaggtca tcggcaacaa gcccgagtcc gacatcctcg tccacacggc ctacgacgag     6060

tccaccgacg agaacgtgat gctcctgacc tcggacgctc ccgagtacaa gccatgggcc     6120

ctggtcatcc aggacagcaa cggcgagaac aagatcaaga tgctctccgg cggcagcccg     6180

aagaagaagc gcaaagtgtg a                                               6201


<210>  87
<211>  2060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  87

Met Pro Lys Lys Lys Arg Lys Val Met Thr Asp Ala Glu Tyr Val Arg 
1               5                   10                  15      


Ile His Glu Lys Leu Asp Ile Tyr Thr Phe Lys Lys Gln Phe Phe Asn 
            20                  25                  30          


Asn Lys Lys Ser Val Ser His Arg Cys Tyr Val Leu Phe Glu Leu Lys 
        35                  40                  45              


Arg Arg Gly Glu Arg Arg Ala Cys Phe Trp Gly Tyr Ala Val Asn Lys 
    50                  55                  60                  


Pro Gln Ser Gly Thr Glu Arg Gly Ile His Ala Glu Ile Phe Ser Ile 
65                  70                  75                  80  


Arg Lys Val Glu Glu Tyr Leu Arg Asp Asn Pro Gly Gln Phe Thr Ile 
                85                  90                  95      


Asn Trp Tyr Ser Ser Trp Ser Pro Val Ser Phe Cys Phe Tyr Leu Tyr 
            100                 105                 110         


Ile Tyr Asn Asn Tyr His Leu Val Val Ile Tyr Phe Lys Tyr Phe Phe 
        115                 120                 125             


Gln Asn Lys Arg Met Tyr Ile Ala Ile Ala Phe Leu Phe Ile Ser Val 
    130                 135                 140                 


Tyr Ile Leu Ile Tyr Asn Phe Ser Asn Ile Pro Lys Phe Val Asp Val 
145                 150                 155                 160 


Gln Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu 
                165                 170                 175     


Leu Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr 
            180                 185                 190         


Tyr Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp 
        195                 200                 205             


Asn Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys 
    210                 215                 220                 


Arg Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg 
225                 230                 235                 240 


Trp Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu 
                245                 250                 255     


Ser Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala 
            260                 265                 270         


Val Ala Glu Tyr Val Arg Ala Leu Phe Asp Phe Asn Gly Asn Asp Glu 
        275                 280                 285             


Glu Asp Leu Pro Phe Lys Lys Gly Asp Ile Leu Arg Ile Arg Asp Lys 
    290                 295                 300                 


Pro Glu Glu Gln Trp Trp Asn Ala Glu Asp Ser Glu Gly Lys Arg Gly 
305                 310                 315                 320 


Met Ile Pro Val Pro Tyr Val Glu Lys Tyr Met Ser Glu Val Glu Phe 
                325                 330                 335     


Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala 
            340                 345                 350         


Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn Asn 
        355                 360                 365             


Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp Pro 
    370                 375                 380                 


Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
385                 390                 395                 400 


Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu Pro 
                405                 410                 415     


Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val 
            420                 425                 430         


Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu Met 
        435                 440                 445             


Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu 
    450                 455                 460                 


Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe Arg 
465                 470                 475                 480 


Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr 
                485                 490                 495     


Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly 
            500                 505                 510         


Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly 
        515                 520                 525             


Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
    530                 535                 540                 


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
545                 550                 555                 560 


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
                565                 570                 575     


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
            580                 585                 590         


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
        595                 600                 605             


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
    610                 615                 620                 


Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly 
625                 630                 635                 640 


Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His 
                645                 650                 655     


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
            660                 665                 670         


Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
        675                 680                 685             


Lys Ala Gln Ser Ser Thr Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    690                 695                 700                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr 
                725                 730                 735     


Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr 
            740                 745                 750         


Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg 
        755                 760                 765             


Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu 
    770                 775                 780                 


Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn 
785                 790                 795                 800 


Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn 
                805                 810                 815     


Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys 
            820                 825                 830         


Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile 
        835                 840                 845             


Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala 
    850                 855                 860                 


Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe 
865                 870                 875                 880 


Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile 
                885                 890                 895     


Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met 
            900                 905                 910         


Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln 
        915                 920                 925             


Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe 
    930                 935                 940                 


Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp 
945                 950                 955                 960 


Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys 
                965                 970                 975     


Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys 
            980                 985                 990         


Gln Lys Leu Pro Lys Phe Lys Pro  Leu Tyr Lys Gln Val  Leu Ser Asp 
        995                 1000                 1005             


Arg Glu  Ser Leu Ser Phe Tyr  Gly Glu Gly Tyr Thr  Ser Asp Glu 
    1010                 1015                 1020             


Glu Val  Leu Glu Val Phe Arg  Asn Thr Leu Asn Lys  Asn Ser Glu 
    1025                 1030                 1035             


Ile Phe  Ser Ser Ile Lys Lys  Leu Glu Lys Leu Phe  Lys Asn Phe 
    1040                 1045                 1050             


Asp Glu  Tyr Ser Ser Ala Gly  Ile Phe Val Lys Asn  Gly Pro Ala 
    1055                 1060                 1065             


Ile Ser  Thr Ile Ser Lys Asp  Ile Phe Gly Glu Trp  Asn Val Ile 
    1070                 1075                 1080             


Arg Asp  Lys Trp Asn Ala Glu  Tyr Asp Asp Ile His  Leu Lys Lys 
    1085                 1090                 1095             


Lys Ala  Val Val Thr Glu Lys  Tyr Glu Asp Asp Arg  Arg Lys Ser 
    1100                 1105                 1110             


Phe Lys  Lys Ile Gly Ser Phe  Ser Leu Glu Gln Leu  Gln Glu Tyr 
    1115                 1120                 1125             


Ala Asp  Ala Asp Leu Ser Val  Val Glu Lys Leu Lys  Glu Ile Ile 
    1130                 1135                 1140             


Ile Gln  Lys Val Asp Glu Ile  Tyr Lys Val Tyr Gly  Ser Ser Glu 
    1145                 1150                 1155             


Lys Leu  Phe Asp Ala Asp Phe  Val Leu Glu Lys Ser  Leu Lys Lys 
    1160                 1165                 1170             


Asn Asp  Ala Val Val Ala Ile  Met Lys Asp Leu Leu  Asp Ser Val 
    1175                 1180                 1185             


Lys Ser  Phe Glu Asn Tyr Ile  Lys Ala Phe Phe Gly  Glu Gly Lys 
    1190                 1195                 1200             


Glu Thr  Asn Arg Asp Glu Ser  Phe Tyr Gly Asp Phe  Val Leu Ala 
    1205                 1210                 1215             


Tyr Asp  Ile Leu Leu Lys Val  Asp His Ile Tyr Asp  Ala Ile Arg 
    1220                 1225                 1230             


Asn Tyr  Val Thr Gln Lys Pro  Tyr Ser Lys Asp Lys  Phe Lys Leu 
    1235                 1240                 1245             


Tyr Phe  Gln Asn Pro Gln Phe  Met Gly Gly Trp Asp  Lys Asp Lys 
    1250                 1255                 1260             


Glu Thr  Asp Tyr Arg Ala Thr  Ile Leu Arg Tyr Gly  Ser Lys Tyr 
    1265                 1270                 1275             


Tyr Leu  Ala Ile Met Asp Lys  Lys Tyr Ala Lys Cys  Leu Gln Lys 
    1280                 1285                 1290             


Ile Asp  Lys Asp Asp Val Asn  Gly Asn Tyr Glu Lys  Ile Asn Tyr 
    1295                 1300                 1305             


Lys Leu  Leu Pro Gly Pro Asn  Lys Met Leu Pro Lys  Val Phe Phe 
    1310                 1315                 1320             


Ser Lys  Lys Trp Met Ala Tyr  Tyr Asn Pro Ser Glu  Asp Ile Gln 
    1325                 1330                 1335             


Lys Ile  Tyr Lys Asn Gly Thr  Phe Lys Lys Gly Asp  Met Phe Asn 
    1340                 1345                 1350             


Leu Asn  Asp Cys His Lys Leu  Ile Asp Phe Phe Lys  Asp Ser Ile 
    1355                 1360                 1365             


Ser Arg  Tyr Pro Lys Trp Ser  Asn Ala Tyr Asp Phe  Asn Phe Ser 
    1370                 1375                 1380             


Glu Thr  Glu Lys Tyr Lys Asp  Ile Ala Gly Phe Tyr  Arg Glu Val 
    1385                 1390                 1395             


Glu Glu  Gln Gly Tyr Lys Val  Ser Phe Glu Ser Ala  Ser Lys Lys 
    1400                 1405                 1410             


Glu Val  Asp Lys Leu Val Glu  Glu Gly Lys Leu Tyr  Met Phe Gln 
    1415                 1420                 1425             


Ile Tyr  Asn Lys Asp Phe Ser  Asp Lys Ser His Gly  Thr Pro Asn 
    1430                 1435                 1440             


Leu His  Thr Met Tyr Phe Lys  Leu Leu Phe Asp Glu  Asn Asn His 
    1445                 1450                 1455             


Gly Gln  Ile Arg Leu Ser Gly  Gly Ala Glu Leu Phe  Met Arg Arg 
    1460                 1465                 1470             


Ala Ser  Leu Lys Lys Glu Glu  Leu Val Val His Pro  Ala Asn Ser 
    1475                 1480                 1485             


Pro Ile  Ala Asn Lys Asn Pro  Asp Asn Pro Lys Lys  Thr Thr Thr 
    1490                 1495                 1500             


Leu Ser  Tyr Asp Val Tyr Lys  Asp Lys Arg Phe Ser  Glu Asp Gln 
    1505                 1510                 1515             


Tyr Glu  Leu His Ile Pro Ile  Ala Ile Asn Lys Cys  Pro Lys Asn 
    1520                 1525                 1530             


Ile Phe  Lys Ile Asn Thr Glu  Val Arg Val Leu Leu  Lys His Asp 
    1535                 1540                 1545             


Asp Asn  Pro Tyr Val Ile Gly  Ile Ala Arg Gly Glu  Arg Asn Leu 
    1550                 1555                 1560             


Leu Tyr  Ile Val Val Val Asp  Gly Lys Gly Asn Ile  Val Glu Gln 
    1565                 1570                 1575             


Tyr Ser  Leu Asn Glu Ile Ile  Asn Asn Phe Asn Gly  Ile Arg Ile 
    1580                 1585                 1590             


Lys Thr  Asp Tyr His Ser Leu  Leu Asp Lys Lys Glu  Lys Glu Arg 
    1595                 1600                 1605             


Phe Glu  Ala Arg Gln Asn Trp  Thr Ser Ile Glu Asn  Ile Lys Glu 
    1610                 1615                 1620             


Leu Lys  Ala Gly Tyr Ile Ser  Gln Val Val His Lys  Ile Cys Glu 
    1625                 1630                 1635             


Leu Val  Glu Lys Tyr Asp Ala  Val Ile Ala Leu Ala  Asp Leu Asn 
    1640                 1645                 1650             


Ser Gly  Phe Lys Asn Ser Arg  Val Lys Val Glu Lys  Gln Val Tyr 
    1655                 1660                 1665             


Gln Lys  Phe Glu Lys Met Leu  Ile Asp Lys Leu Asn  Tyr Met Val 
    1670                 1675                 1680             


Asp Lys  Lys Ser Asn Pro Cys  Ala Thr Gly Gly Ala  Leu Lys Gly 
    1685                 1690                 1695             


Tyr Gln  Ile Thr Asn Lys Phe  Glu Ser Phe Lys Ser  Met Ser Thr 
    1700                 1705                 1710             


Gln Asn  Gly Phe Ile Phe Tyr  Ile Pro Ala Trp Leu  Thr Ser Lys 
    1715                 1720                 1725             


Ile Asp  Pro Ser Thr Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr 
    1730                 1735                 1740             


Thr Ser  Ile Ala Asp Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg 
    1745                 1750                 1755             


Ile Met  Tyr Val Pro Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp 
    1760                 1765                 1770             


Tyr Lys  Asn Phe Ser Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp 
    1775                 1780                 1785             


Lys Leu  Tyr Ser Tyr Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro 
    1790                 1795                 1800             


Lys Lys  Asn Asn Val Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser 
    1805                 1810                 1815             


Ala Tyr  Lys Glu Leu Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln 
    1820                 1825                 1830             


Gly Asp  Ile Arg Ala Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe 
    1835                 1840                 1845             


Tyr Ser  Ser Phe Met Ala Leu  Met Ser Leu Met Leu  Gln Met Arg 
    1850                 1855                 1860             


Asn Ser  Ile Thr Gly Arg Thr  Asp Val Ala Phe Leu  Ile Ser Pro 
    1865                 1870                 1875             


Val Lys  Asn Ser Asp Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu 
    1880                 1885                 1890             


Ala Gln  Glu Asn Ala Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly 
    1895                 1900                 1905             


Ala Tyr  Asn Ile Ala Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe 
    1910                 1915                 1920             


Lys Lys  Ala Glu Asp Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile 
    1925                 1930                 1935             


Ser Asn  Lys Glu Trp Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1940                 1945                 1950             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Ser Gly Gly  Ser Thr Asn 
    1955                 1960                 1965             


Leu Ser  Asp Ile Ile Glu Lys  Glu Thr Gly Lys Gln  Leu Val Ile 
    1970                 1975                 1980             


Gln Glu  Ser Ile Leu Met Leu  Pro Glu Glu Val Glu  Glu Val Ile 
    1985                 1990                 1995             


Gly Asn  Lys Pro Glu Ser Asp  Ile Leu Val His Thr  Ala Tyr Asp 
    2000                 2005                 2010             


Glu Ser  Thr Asp Glu Asn Val  Met Leu Leu Thr Ser  Asp Ala Pro 
    2015                 2020                 2025             


Glu Tyr  Lys Pro Trp Ala Leu  Val Ile Gln Asp Ser  Asn Gly Glu 
    2030                 2035                 2040             


Asn Lys  Ile Lys Met Leu Ser  Gly Gly Ser Pro Lys  Lys Lys Arg 
    2045                 2050                 2055             


Lys Val  
    2060 


<210>  88
<211>  6183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
atgtccgagg tggagttcag ccacgagtac tggatgaggc acgctctcac cctggctaag       60

agggcgtggg acgagaggga ggtgccggtg ggcgccgtgc tcgtccacaa caaccgcgtg      120

atcggcgagg gctggaacag gcccatcggc aggcacgacc caaccgctca cgccgagatc      180

atggctctca ggcagggcgg cctggtcatg cagaactaca ggctgatcga cgcgaccctc      240

tacgtgaccc tcgagccctg cgtcatggta agtttctgct tctacctttg atatatatat      300

aataattatc attaattagt agtaatataa tatttcaaat atttttttca aaataaaaga      360

atgtagtata tagcaattgc ttttctgtag tttataagtg tgtatatttt aatttataac      420

ttttctaata tatgaccaaa atttgttgat gtgcagtgcg cgggcgccat gatccactcc      480

aggatcggca gggtggtctt cggcgctagg gacgccaaga cgggcgctgc gggcagcctc      540

atggacgtgc tgcaccaccc cggcatgaac caccgcgtcg agatcaccga gggcatcctc      600

gcggacgagt gcgctgcgct cctgtccgac ttcttcagga tgcgcaggca ggagatcaag      660

gcccagaaga aggcgcagtc cagcaccgac tccggcggct ccagcggcgg ctccagcggc      720

agcgagaccc cgggcacgtc cgagagcgcg acgcccgaga gcagcggcgg ctccagcggc      780

ggctcctcgg aggtcgagtt cagccatgag tactggatga ggcatgccct gactctcgct      840

aagagggcgc gggatgagcg cgaggtgccg gtgggggccg tgctcgtcct gaacaaccgc      900

gtgatcgggg agggctggaa ccgggctatc ggcctccacg acccaacggc ccatgccgag      960

atcatggccc tgaggcaggg cggcctggtc atgcaaaact acaggctcat cgacgccacc     1020

ctctacgtga ccttcgagcc atgcgtgatg tgcgcggggg ccatgatcca ctcgaggatt     1080

gggagggtgg tcttcggcgt gcgcaacgct aagacggggg ccgccggcag cctcatggac     1140

gtcctgcact acccgggcat gaaccacagg gtggagatta ccgagggcat cctggccgat     1200

gagtgcgccg cgctcctgtg ctacttcttc cgcatgccca ggcaggtctt caacgcgcag     1260

aagaaggccc agagctccac tgatggcagc gcggagtacg ttcgggctct gttcgacttc     1320

aacggcaacg acgaggagga cctcccgttc aagaagggcg acatcctgcg catcagggac     1380

aagccggagg agcagtggtg gaacgccgag gactccgagg gcaagagggg catgatcccg     1440

gtcccctacg tggagaagta catgaccgac gcggagtatg tgcgcatcca cgagaagctc     1500

gacatctaca ccttcaagaa gcagttcttc aacaacaaga agagcgtctc ccacaggtgc     1560

tacgtgctct tcgagctgaa gaggcgcggc gagcgcaggg cctgcttctg gggctacgcc     1620

gtgaacaagc cgcagagcgg caccgagcgc ggcatccacg ccgagatctt cagcatccgc     1680

aaggtggagg agtacctcag ggacaacccg ggccagttca ccatcaactg gtacagctcc     1740

tggagcccgt gcgcggactg cgccgagaag atcctggagt ggtacaacca ggagctgagg     1800

ggcaacggcc acaccctgaa gatctgggcc tgcaagctct actacgagaa gaacgcgagg     1860

aaccagatcg gcctgtggaa cctccgcgac aacggcgtcg gcctcaacgt gatggtctcc     1920

gagcactacc agtgctgccg caagatcttc atccagtcca gccacaacca gctcaacgag     1980

aacaggtggc tggagaagac cctgaagagg gccgagaagc gcaggtccga gctcagcatc     2040

atgatccagg tgaagatcct ccacaccacg aagtcccccg ccgtgggggg cgggggctca     2100

ggcgggggcg ggagcggcgg cgggggctct gggggcggcg gcagcggcgg gggcggcagc     2160

gggggcggcg ggtcgatgag caagctggag aagttcacga actgctactc cctcagcaag     2220

accctgaggt tcaaggcgat cccggtcggc aagacccagg agaacatcga caacaagcgg     2280

ctgctggtgg aggacgagaa gagggctgag gactacaagg gcgtgaagaa gctcctggac     2340

cgctactacc tgtccttcat caacgacgtg ctccacagca tcaagctcaa gaacctgaac     2400

aactacatca gcctcttcag gaagaagacg cgcaccgaga aggagaacaa ggagctcgag     2460

aacctggaga tcaacctgag gaaggagatc gccaaggcgt tcaagggcaa cgagggctac     2520

aagtccctct tcaagaagga catcatcgag acgatcctcc cggagttcct ggacgacaag     2580

gacgagatcg ccctggtcaa ctccttcaac ggcttcacca cggcgttcac cggcttcttc     2640

gacaaccgcg agaacatgtt cagcgaggag gccaagtcca cgagcatcgc gttcaggtgc     2700

atcaacgaga acctcacccg ctacatctcc aacatggaca tcttcgagaa ggtcgacgcg     2760

atcttcgaca agcacgaggt gcaggagatc aaggagaaga tcctgaacag cgactacgac     2820

gtcgaggact tcttcgaggg cgagttcttc aacttcgtcc tcacgcagga gggcatcgac     2880

gtgtacaacg ccatcatcgg tggcttcgtg accgagtccg gcgagaagat caagggcctg     2940

aacgagtaca tcaacctcta caaccagaag accaagcaga agctgccgaa gttcaagccc     3000

ctgtacaagc aggtgctctc cgacagggag tccctcagct tctacggcga gggctacacg     3060

agcgacgagg aggtcctgga ggtgttccgc aacaccctca acaagaacag cgagatcttc     3120

tccagcatca agaagctcga gaagctgttc aagaacttcg acgagtactc cagcgccggc     3180

atcttcgtca agaacggccc ggcgatctcc acgatcagca aggacatctt cggcgagtgg     3240

aacgtgatcc gcgacaagtg gaacgccgag tacgacgaca tccacctcaa gaagaaggcg     3300

gtggtcaccg agaagtacga ggacgacagg cgcaagtcct tcaagaagat cggctccttc     3360

agcctcgagc agctgcagga gtacgccgac gcggacctga gcgtggtcga gaagctcaag     3420

gagatcatca tccagaaggt cgacgagatc tacaaggtgt acggctccag cgagaagctc     3480

ttcgacgcgg acttcgtcct cgagaagtcc ctgaagaaga acgacgccgt ggtcgcgatc     3540

atgaaggacc tcctggactc cgtgaagagc ttcgagaatt acatcaaggc cttcttcggc     3600

gagggcaagg agacgaacag ggacgagtcc ttctacggcg acttcgtcct ggcctacgac     3660

atcctcctga aggtggacca catctacgac gcgatccgca actacgtgac ccagaagccg     3720

tacagcaagg acaagttcaa gctctacttc cagaaccccc agttcatggg cggctgggac     3780

aaggacaagg agacggacta cagggcgacc atcctgcgct acggcagcaa gtactacctc     3840

gccatcatgg acaagaagta cgcgaagtgc ctgcagaaga tcgacaagga cgacgtcaac     3900

ggcaactacg agaagatcaa ctacaagctc ctgccgggcc ccaacaagat gctcccgaag     3960

gtgttcttct ccaagaagtg gatggcctac tacaacccca gcgaggacat ccagaagatc     4020

tacaagaacg gcacgttcaa gaagggcgac atgttcaacc tgaacgactg ccacaagctc     4080

atcgacttct tcaaggactc catcagccgc tacccgaagt ggtccaacgc ctacgacttc     4140

aacttcagcg agaccgagaa gtacaaggac atcgcgggct tctaccgcga ggtcgaggag     4200

cagggctaca aggtgtcctt cgagtccgcc agcaagaagg aggtcgacaa gctggtggag     4260

gagggcaagc tctacatgtt ccagatctac aacaaggact tctccgacaa gagccacggc     4320

acgcccaacc tgcacaccat gtacttcaag ctcctgttcg acgagaacaa ccacggccag     4380

atcaggctgt ccggcggcgc cgagctcttc atgaggaggg cgagcctgaa gaaggaggag     4440

ctggtggtcc accccgctaa cagcccaatc gcgaacaaga acccggacaa ccccaagaag     4500

accacgaccc tgtcctacga cgtgtacaag gacaagaggt tcagcgagga ccagtacgag     4560

ctccacatcc cgatcgcgat caacaagtgc cccaagaaca tcttcaagat caacaccgag     4620

gtccgcgtgc tcctgaagca cgacgacaac ccctacgtga tcggcatcgc taggggcgag     4680

aggaacctcc tgtacatcgt ggtcgtggac ggcaagggca acatcgtgga gcagtactcc     4740

ctcaacgaga tcatcaacaa cttcaacggc atcaggatca agacggacta ccacagcctc     4800

ctggacaaga aggagaagga gaggttcgag gcccgccaga actggacctc catcgagaac     4860

atcaaggagc tgaaggcggg ctacatcagc caggtcgtgc acaagatctg cgagctcgtc     4920

gagaagtacg acgccgtgat cgccctcgcg gacctgaact ccggcttcaa gaacagccgc     4980

gtcaaggtgg agaagcaggt ctaccagaag ttcgagaaga tgctcatcga caagctgaac     5040

tacatggtgg acaagaagtc caacccctgc gctacgggcg gcgcgctgaa gggctaccag     5100

atcaccaaca agttcgagag cttcaagtcc atgagcactc agaacggctt catcttctac     5160

atcccggcgt ggctcacgtc caagatcgac cccagcaccg gcttcgtcaa cctcctgaag     5220

acgaagtaca cctccatcgc cgacagcaag aagttcatct ccagcttcga ccgcatcatg     5280

tatgtgccgg aggaggacct gttcgagttc gccctcgact acaagaactt ctcccgcacg     5340

gacgcggact acatcaagaa gtggaagctg tacagctacg gcaaccgcat ccgcatcttc     5400

aggaacccca agaagaacaa cgtcttcgac tgggaggagg tgtgcctgac ctccgcgtac     5460

aaggagctct tcaacaagta cggcatcaac taccagcagg gcgacatcag ggctctcctg     5520

tgcgagcaga gcgacaaggc cttctactcc agcttcatgg cgctgatgtc cctcatgctg     5580

cagatgagga actcgatcac cggcaggacg gacgtggcct tcctcatctc cccggtgaag     5640

aacagcgacg gcatcttcta cgactccagg aactacgagg cccaggagaa cgcgatcctc     5700

ccaaagaacg cggacgccaa cggcgcctac aacatcgcca ggaaggtcct ctgggctatc     5760

ggccagttca agaaggcgga ggacgagaag ctggacaagg tgaagatcgc catcagcaac     5820

aaggagtggc tcgagtacgc ccagacctcg gtcaagcacg gcagcccgaa gaagaagcgc     5880

aaggtgtccg gcggcagcac gaacctgtcc gacatcatcg agaaggagac cggcaagcag     5940

ctcgtgatcc aggagagcat cctcatgctg ccggaggagg tcgaggaggt catcggcaac     6000

aagcccgagt ccgacatcct cgtccacacg gcctacgacg agtccaccga cgagaacgtg     6060

atgctcctga cctcggacgc tcccgagtac aagccatggg ccctggtcat ccaggacagc     6120

aacggcgaga acaagatcaa gatgctctcc ggcggcagcc cgaagaagaa gcgcaaagtg     6180

tga                                                                   6183


<210>  89
<211>  2054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  89

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Val Ser Phe Cys Phe Tyr Leu 
                85                  90                  95      


Tyr Ile Tyr Asn Asn Tyr His Leu Val Val Ile Tyr Phe Lys Tyr Phe 
            100                 105                 110         


Phe Gln Asn Lys Arg Met Tyr Ile Ala Ile Ala Phe Leu Phe Ile Ser 
        115                 120                 125             


Val Tyr Ile Leu Ile Tyr Asn Phe Ser Asn Ile Pro Lys Phe Val Asp 
    130                 135                 140                 


Val Gln Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val 
145                 150                 155                 160 


Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp 
                165                 170                 175     


Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly 
            180                 185                 190         


Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe Arg Met 
        195                 200                 205             


Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp 
    210                 215                 220                 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
225                 230                 235                 240 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
            260                 265                 270         


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
        275                 280                 285             


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
    290                 295                 300                 


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
305                 310                 315                 320 


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
                325                 330                 335     


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
            340                 345                 350         


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
        355                 360                 365             


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
    370                 375                 380                 


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
385                 390                 395                 400 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
                405                 410                 415     


Ala Gln Ser Ser Thr Asp Gly Ser Ala Glu Tyr Val Arg Ala Leu Phe 
            420                 425                 430         


Asp Phe Asn Gly Asn Asp Glu Glu Asp Leu Pro Phe Lys Lys Gly Asp 
        435                 440                 445             


Ile Leu Arg Ile Arg Asp Lys Pro Glu Glu Gln Trp Trp Asn Ala Glu 
    450                 455                 460                 


Asp Ser Glu Gly Lys Arg Gly Met Ile Pro Val Pro Tyr Val Glu Lys 
465                 470                 475                 480 


Tyr Met Thr Asp Ala Glu Tyr Val Arg Ile His Glu Lys Leu Asp Ile 
                485                 490                 495     


Tyr Thr Phe Lys Lys Gln Phe Phe Asn Asn Lys Lys Ser Val Ser His 
            500                 505                 510         


Arg Cys Tyr Val Leu Phe Glu Leu Lys Arg Arg Gly Glu Arg Arg Ala 
        515                 520                 525             


Cys Phe Trp Gly Tyr Ala Val Asn Lys Pro Gln Ser Gly Thr Glu Arg 
    530                 535                 540                 


Gly Ile His Ala Glu Ile Phe Ser Ile Arg Lys Val Glu Glu Tyr Leu 
545                 550                 555                 560 


Arg Asp Asn Pro Gly Gln Phe Thr Ile Asn Trp Tyr Ser Ser Trp Ser 
                565                 570                 575     


Pro Cys Ala Asp Cys Ala Glu Lys Ile Leu Glu Trp Tyr Asn Gln Glu 
            580                 585                 590         


Leu Arg Gly Asn Gly His Thr Leu Lys Ile Trp Ala Cys Lys Leu Tyr 
        595                 600                 605             


Tyr Glu Lys Asn Ala Arg Asn Gln Ile Gly Leu Trp Asn Leu Arg Asp 
    610                 615                 620                 


Asn Gly Val Gly Leu Asn Val Met Val Ser Glu His Tyr Gln Cys Cys 
625                 630                 635                 640 


Arg Lys Ile Phe Ile Gln Ser Ser His Asn Gln Leu Asn Glu Asn Arg 
                645                 650                 655     


Trp Leu Glu Lys Thr Leu Lys Arg Ala Glu Lys Arg Arg Ser Glu Leu 
            660                 665                 670         


Ser Ile Met Ile Gln Val Lys Ile Leu His Thr Thr Lys Ser Pro Ala 
        675                 680                 685             


Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    690                 695                 700                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
705                 710                 715                 720 


Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu 
                725                 730                 735     


Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn 
            740                 745                 750         


Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly 
        755                 760                 765             


Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val 
    770                 775                 780                 


Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe 
785                 790                 795                 800 


Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu 
                805                 810                 815     


Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu 
            820                 825                 830         


Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro 
        835                 840                 845             


Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn 
    850                 855                 860                 


Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met 
865                 870                 875                 880 


Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn 
                885                 890                 895     


Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val 
            900                 905                 910         


Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile 
        915                 920                 925             


Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe 
    930                 935                 940                 


Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile 
945                 950                 955                 960 


Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu 
                965                 970                 975     


Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe 
            980                 985                 990         


Lys Pro Leu Tyr Lys Gln Val Leu  Ser Asp Arg Glu Ser  Leu Ser Phe 
        995                 1000                 1005             


Tyr Gly  Glu Gly Tyr Thr Ser  Asp Glu Glu Val Leu  Glu Val Phe 
    1010                 1015                 1020             


Arg Asn  Thr Leu Asn Lys Asn  Ser Glu Ile Phe Ser  Ser Ile Lys 
    1025                 1030                 1035             


Lys Leu  Glu Lys Leu Phe Lys  Asn Phe Asp Glu Tyr  Ser Ser Ala 
    1040                 1045                 1050             


Gly Ile  Phe Val Lys Asn Gly  Pro Ala Ile Ser Thr  Ile Ser Lys 
    1055                 1060                 1065             


Asp Ile  Phe Gly Glu Trp Asn  Val Ile Arg Asp Lys  Trp Asn Ala 
    1070                 1075                 1080             


Glu Tyr  Asp Asp Ile His Leu  Lys Lys Lys Ala Val  Val Thr Glu 
    1085                 1090                 1095             


Lys Tyr  Glu Asp Asp Arg Arg  Lys Ser Phe Lys Lys  Ile Gly Ser 
    1100                 1105                 1110             


Phe Ser  Leu Glu Gln Leu Gln  Glu Tyr Ala Asp Ala  Asp Leu Ser 
    1115                 1120                 1125             


Val Val  Glu Lys Leu Lys Glu  Ile Ile Ile Gln Lys  Val Asp Glu 
    1130                 1135                 1140             


Ile Tyr  Lys Val Tyr Gly Ser  Ser Glu Lys Leu Phe  Asp Ala Asp 
    1145                 1150                 1155             


Phe Val  Leu Glu Lys Ser Leu  Lys Lys Asn Asp Ala  Val Val Ala 
    1160                 1165                 1170             


Ile Met  Lys Asp Leu Leu Asp  Ser Val Lys Ser Phe  Glu Asn Tyr 
    1175                 1180                 1185             


Ile Lys  Ala Phe Phe Gly Glu  Gly Lys Glu Thr Asn  Arg Asp Glu 
    1190                 1195                 1200             


Ser Phe  Tyr Gly Asp Phe Val  Leu Ala Tyr Asp Ile  Leu Leu Lys 
    1205                 1210                 1215             


Val Asp  His Ile Tyr Asp Ala  Ile Arg Asn Tyr Val  Thr Gln Lys 
    1220                 1225                 1230             


Pro Tyr  Ser Lys Asp Lys Phe  Lys Leu Tyr Phe Gln  Asn Pro Gln 
    1235                 1240                 1245             


Phe Met  Gly Gly Trp Asp Lys  Asp Lys Glu Thr Asp  Tyr Arg Ala 
    1250                 1255                 1260             


Thr Ile  Leu Arg Tyr Gly Ser  Lys Tyr Tyr Leu Ala  Ile Met Asp 
    1265                 1270                 1275             


Lys Lys  Tyr Ala Lys Cys Leu  Gln Lys Ile Asp Lys  Asp Asp Val 
    1280                 1285                 1290             


Asn Gly  Asn Tyr Glu Lys Ile  Asn Tyr Lys Leu Leu  Pro Gly Pro 
    1295                 1300                 1305             


Asn Lys  Met Leu Pro Lys Val  Phe Phe Ser Lys Lys  Trp Met Ala 
    1310                 1315                 1320             


Tyr Tyr  Asn Pro Ser Glu Asp  Ile Gln Lys Ile Tyr  Lys Asn Gly 
    1325                 1330                 1335             


Thr Phe  Lys Lys Gly Asp Met  Phe Asn Leu Asn Asp  Cys His Lys 
    1340                 1345                 1350             


Leu Ile  Asp Phe Phe Lys Asp  Ser Ile Ser Arg Tyr  Pro Lys Trp 
    1355                 1360                 1365             


Ser Asn  Ala Tyr Asp Phe Asn  Phe Ser Glu Thr Glu  Lys Tyr Lys 
    1370                 1375                 1380             


Asp Ile  Ala Gly Phe Tyr Arg  Glu Val Glu Glu Gln  Gly Tyr Lys 
    1385                 1390                 1395             


Val Ser  Phe Glu Ser Ala Ser  Lys Lys Glu Val Asp  Lys Leu Val 
    1400                 1405                 1410             


Glu Glu  Gly Lys Leu Tyr Met  Phe Gln Ile Tyr Asn  Lys Asp Phe 
    1415                 1420                 1425             


Ser Asp  Lys Ser His Gly Thr  Pro Asn Leu His Thr  Met Tyr Phe 
    1430                 1435                 1440             


Lys Leu  Leu Phe Asp Glu Asn  Asn His Gly Gln Ile  Arg Leu Ser 
    1445                 1450                 1455             


Gly Gly  Ala Glu Leu Phe Met  Arg Arg Ala Ser Leu  Lys Lys Glu 
    1460                 1465                 1470             


Glu Leu  Val Val His Pro Ala  Asn Ser Pro Ile Ala  Asn Lys Asn 
    1475                 1480                 1485             


Pro Asp  Asn Pro Lys Lys Thr  Thr Thr Leu Ser Tyr  Asp Val Tyr 
    1490                 1495                 1500             


Lys Asp  Lys Arg Phe Ser Glu  Asp Gln Tyr Glu Leu  His Ile Pro 
    1505                 1510                 1515             


Ile Ala  Ile Asn Lys Cys Pro  Lys Asn Ile Phe Lys  Ile Asn Thr 
    1520                 1525                 1530             


Glu Val  Arg Val Leu Leu Lys  His Asp Asp Asn Pro  Tyr Val Ile 
    1535                 1540                 1545             


Gly Ile  Ala Arg Gly Glu Arg  Asn Leu Leu Tyr Ile  Val Val Val 
    1550                 1555                 1560             


Asp Gly  Lys Gly Asn Ile Val  Glu Gln Tyr Ser Leu  Asn Glu Ile 
    1565                 1570                 1575             


Ile Asn  Asn Phe Asn Gly Ile  Arg Ile Lys Thr Asp  Tyr His Ser 
    1580                 1585                 1590             


Leu Leu  Asp Lys Lys Glu Lys  Glu Arg Phe Glu Ala  Arg Gln Asn 
    1595                 1600                 1605             


Trp Thr  Ser Ile Glu Asn Ile  Lys Glu Leu Lys Ala  Gly Tyr Ile 
    1610                 1615                 1620             


Ser Gln  Val Val His Lys Ile  Cys Glu Leu Val Glu  Lys Tyr Asp 
    1625                 1630                 1635             


Ala Val  Ile Ala Leu Ala Asp  Leu Asn Ser Gly Phe  Lys Asn Ser 
    1640                 1645                 1650             


Arg Val  Lys Val Glu Lys Gln  Val Tyr Gln Lys Phe  Glu Lys Met 
    1655                 1660                 1665             


Leu Ile  Asp Lys Leu Asn Tyr  Met Val Asp Lys Lys  Ser Asn Pro 
    1670                 1675                 1680             


Cys Ala  Thr Gly Gly Ala Leu  Lys Gly Tyr Gln Ile  Thr Asn Lys 
    1685                 1690                 1695             


Phe Glu  Ser Phe Lys Ser Met  Ser Thr Gln Asn Gly  Phe Ile Phe 
    1700                 1705                 1710             


Tyr Ile  Pro Ala Trp Leu Thr  Ser Lys Ile Asp Pro  Ser Thr Gly 
    1715                 1720                 1725             


Phe Val  Asn Leu Leu Lys Thr  Lys Tyr Thr Ser Ile  Ala Asp Ser 
    1730                 1735                 1740             


Lys Lys  Phe Ile Ser Ser Phe  Asp Arg Ile Met Tyr  Val Pro Glu 
    1745                 1750                 1755             


Glu Asp  Leu Phe Glu Phe Ala  Leu Asp Tyr Lys Asn  Phe Ser Arg 
    1760                 1765                 1770             


Thr Asp  Ala Asp Tyr Ile Lys  Lys Trp Lys Leu Tyr  Ser Tyr Gly 
    1775                 1780                 1785             


Asn Arg  Ile Arg Ile Phe Arg  Asn Pro Lys Lys Asn  Asn Val Phe 
    1790                 1795                 1800             


Asp Trp  Glu Glu Val Cys Leu  Thr Ser Ala Tyr Lys  Glu Leu Phe 
    1805                 1810                 1815             


Asn Lys  Tyr Gly Ile Asn Tyr  Gln Gln Gly Asp Ile  Arg Ala Leu 
    1820                 1825                 1830             


Leu Cys  Glu Gln Ser Asp Lys  Ala Phe Tyr Ser Ser  Phe Met Ala 
    1835                 1840                 1845             


Leu Met  Ser Leu Met Leu Gln  Met Arg Asn Ser Ile  Thr Gly Arg 
    1850                 1855                 1860             


Thr Asp  Val Ala Phe Leu Ile  Ser Pro Val Lys Asn  Ser Asp Gly 
    1865                 1870                 1875             


Ile Phe  Tyr Asp Ser Arg Asn  Tyr Glu Ala Gln Glu  Asn Ala Ile 
    1880                 1885                 1890             


Leu Pro  Lys Asn Ala Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg 
    1895                 1900                 1905             


Lys Val  Leu Trp Ala Ile Gly  Gln Phe Lys Lys Ala  Glu Asp Glu 
    1910                 1915                 1920             


Lys Leu  Asp Lys Val Lys Ile  Ala Ile Ser Asn Lys  Glu Trp Leu 
    1925                 1930                 1935             


Glu Tyr  Ala Gln Thr Ser Val  Lys His Gly Ser Pro  Lys Lys Lys 
    1940                 1945                 1950             


Arg Lys  Val Ser Gly Gly Ser  Thr Asn Leu Ser Asp  Ile Ile Glu 
    1955                 1960                 1965             


Lys Glu  Thr Gly Lys Gln Leu  Val Ile Gln Glu Ser  Ile Leu Met 
    1970                 1975                 1980             


Leu Pro  Glu Glu Val Glu Glu  Val Ile Gly Asn Lys  Pro Glu Ser 
    1985                 1990                 1995             


Asp Ile  Leu Val His Thr Ala  Tyr Asp Glu Ser Thr  Asp Glu Asn 
    2000                 2005                 2010             


Val Met  Leu Leu Thr Ser Asp  Ala Pro Glu Tyr Lys  Pro Trp Ala 
    2015                 2020                 2025             


Leu Val  Ile Gln Asp Ser Asn  Gly Glu Asn Lys Ile  Lys Met Leu 
    2030                 2035                 2040             


Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val 
    2045                 2050                 


<210>  90
<211>  23
<212>  DNA
<213>  Zea mays

<400>  90
aatcaatggg aagcctatct acc                                               23


<210>  91
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91
atgtccgagg tggagttcag ccacgagtac tggatgaggc acgctctcac cctggctaag       60

agggcgtggg acgagaggga ggtgccggtg ggcgccgtgc tcgtccacaa caaccgcgtg      120

atcggcgagg gctggaacag gcccatcggc aggcacgacc caaccgctca cgccgagatc      180

atggctctca ggcagggcgg cctggtcatg cagaactaca ggctgatcga cgcgaccctc      240

tacgtgaccc tcgagccctg cgtcatggta agtttctgct tctacctttg atatatatat      300

aataattatc attaattagt agtaatataa tatttcaaat atttttttca aaataaaaga      360

atgtagtata tagcaattgc ttttctgtag tttataagtg tgtatatttt aatttataac      420

ttttctaata tatgaccaaa atttgttgat gtgcagtgcg cgggcgccat gatccactcc      480

aggatcggca gggtggtctt cggcgctagg gacgccaaga cgggcgctgc gggcagcctc      540

atggacgtgc tgcaccaccc cggcatgaac caccgcgtcg agatcaccga gggcatcctc      600

gcggacgagt gcgctgcgct cctgtccgac ttcttcagga tgcgcaggca ggagatcaag      660

gcccagaaga aggcgcagtc cagcaccgac tccggcggct ccagcggcgg ctccagcggc      720

agcgagaccc cgggcacgtc cgagagcgcg acgcccgaga gcagcggcgg ctccagcggc      780

ggctcctcgg aggtcgagtt cagccatgag tactggatga ggcatgccct gactctcgct      840

aagagggcgc gggatgagcg cgaggtgccg gtgggggccg tgctcgtcct gaacaaccgc      900

gtgatcgggg agggctggaa ccgggctatc ggcctccacg acccaacggc ccatgccgag      960

atcatggccc tgaggcaggg cggcctggtc atgcaaaact acaggctcat cgacgccacc     1020

ctctacgtga ccttcgagcc atgcgtgatg tgcgcggggg ccatgatcca ctcgaggatt     1080

gggagggtgg tcttcggcgt gcgcaacgct aagacggggg ccgccggcag cctcatggac     1140

gtcctgcact acccgggcat gaaccacagg gtggagatta ccgagggcat cctggccgat     1200

gagtgcgccg cgctcctgtg ctacttcttc cgcatgccca ggcaggtctt caacgcgcag     1260

aagaaggccc agagctccac tgat                                            1284


<210>  92
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Val Ser Phe Cys Phe Tyr Leu 
                85                  90                  95      


Tyr Ile Tyr Asn Asn Tyr His Leu Val Val Ile Tyr Phe Lys Tyr Phe 
            100                 105                 110         


Phe Gln Asn Lys Arg Met Tyr Ile Ala Ile Ala Phe Leu Phe Ile Ser 
        115                 120                 125             


Val Tyr Ile Leu Ile Tyr Asn Phe Ser Asn Ile Pro Lys Phe Val Asp 
    130                 135                 140                 


Val Gln Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val 
145                 150                 155                 160 


Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp 
                165                 170                 175     


Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly 
            180                 185                 190         


Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe Arg Met 
        195                 200                 205             


Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp 
    210                 215                 220                 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
225                 230                 235                 240 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                245                 250                 255     


Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
            260                 265                 270         


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
        275                 280                 285             


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
    290                 295                 300                 


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
305                 310                 315                 320 


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
                325                 330                 335     


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
            340                 345                 350         


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
        355                 360                 365             


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
    370                 375                 380                 


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
385                 390                 395                 400 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
                405                 410                 415     


Ala Gln Ser Ser Thr Asp 
            420         


