                         SEQUENCE LISTING

<110>  SillaJen, Inc.
       Regeneron Pharmaceuticals, Inc.
 
<120>  IMMUNE ASSAY FOR MONITORING RESPONSE TO ONCOLYTIC VACCINIA VIRUS 
       AND USES THEREOF

<130>  090404-5005 WO

<140>  PCT/US2020/052222
<141>  2020-09-23

<150>  US 62/904,441
<151>  2019-09-23

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human HLA class I Vaccinia epitope

<400>  1

Phe Leu Asn Ile Ser Trp Phe Tyr Ile 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human HLA class I Vaccinia epitope

<400>  2

Phe Leu Val Ile Ala Ile Asn Ala Met 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  3

Tyr Leu Phe Arg Cys Val Asp Ala Val 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  4

Tyr Ile Tyr Gly Ile Pro Leu Ser Leu 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  5

Ser Leu Phe Lys Asn Val Arg Leu Leu 
1               5                   


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  6

Ser Val Val Thr Leu Leu Cys Val Leu Pro Ala Val Val Tyr Ser 
1               5                   10                  15  


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  7

Phe Leu Ile Asp Leu Ala Phe Leu Ile 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  8

Leu Met Asp Glu Asn Thr Tyr Ala Met 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  9

Met Met Leu Val Pro Leu Ile Thr Val 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  10

Ile Leu Ser Asp Glu Asn Tyr Leu Leu 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  11

Lys Ile Asp Tyr Tyr Ile Pro Tyr Val 
1               5                   


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  12

Asn Leu Phe Asp Ile Pro Leu Leu Thr Val 
1               5                   10  


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  13

Phe Leu Thr Ser Val Ile Asn Arg Val 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  14

Arg Met Ile Ala Ile Ser Ala Lys Val 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  15

Tyr Val Asn Ala Ile Leu Tyr Gln Ile 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  16

Gly Leu Asn Asp Tyr Leu His Ser Val 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  17

Ser Met His Phe Tyr Gly Trp Ser Leu 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  18

Lys Leu Leu Leu Trp Phe Asn Tyr Leu 
1               5                   


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  19

Tyr Leu Tyr Thr Glu Tyr Phe Leu Phe Leu 
1               5                   10  


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  20

Ser Leu Lys Asp Val Leu Val Ser Val 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  21

Ser Leu Ser Ala Tyr Ile Ile Arg Val 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  22

Lys Val Asp Asp Thr Phe Tyr Tyr Val 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  23

Ala Leu Asp Glu Lys Leu Phe Leu Ile 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  24

Ala Met Leu Asn Gly Leu Ile Tyr Val 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  25

Lys Leu Phe Thr His Asp Ile Met Leu 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  26

Arg Val Tyr Glu Ala Leu Tyr Tyr Val 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  27

Leu Leu Tyr Ala His Ile Asn Ala Leu 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  28

Cys Leu Thr Glu Tyr Ile Leu Trp Val 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  29

Thr Leu Leu Asp His Ile Arg Thr Ala 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  30

Lys Leu Phe Ser Asp Ile Ser Ala Ile 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  31

Ile Leu Asp Asp Asn Leu Tyr Lys Val 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  32

Lys Leu Ile Ile His Asn Pro Glu Leu 
1               5                   


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  33

Lys Ile Thr Ser Tyr Lys Phe Glu Ser Val 
1               5                   10  


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  34

Ile Val Ile Glu Ala Ile His Thr Val 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  35

Gly Thr His Val Leu Leu Pro Phe Tyr 
1               5                   


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  36

Leu Arg Ala Ala Met Ile Ser Leu Ala Lys Lys Ile Asp Val Gln 
1               5                   10                  15  


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  37

Val Ser Glu His Phe Ser Leu Leu Phe 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  38

Gln Ser Asp Thr Val Phe Asp Tyr Tyr 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  39

Asp Met Cys Asp Ile Tyr Leu Leu Tyr 
1               5                   


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  40

Phe Gly Asp Ser Lys Glu Pro Val Pro Tyr 
1               5                   10  


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  41

Leu Ser Asp Leu Lys Lys Thr Ile Tyr 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  42

Ile Thr Asp Phe Asn Ile Asp Thr Tyr 
1               5                   


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  43

Ala Val Lys Asp Val Thr Ile Thr Lys Lys 
1               5                   10  


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  44

Lys Val Met Phe Val Ile Arg Phe Lys 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  45

Thr Tyr Asn Asp His Ile Val Asn Leu 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  46

Val Trp Ile Asn Asn Ser Trp Lys Phe 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  47

Lys Tyr Gln Ser Pro Val Asn Ile Phe 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  48

Asp Thr Arg Gly Ile Phe Ser Ala Tyr 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  49

Val Tyr Ile Asn His Pro Phe Met Tyr 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  50

Thr Val Ala Asp Val Arg His Cys Leu 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  51

Met Pro Ala Tyr Ile Arg Asn Thr Leu 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  52

His Pro Arg His Tyr Ala Thr Val Met 
1               5                   


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  53

Lys Pro Lys Pro Ala Val Arg Phe Ala Ile 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  54

Arg Pro Met Ser Leu Arg Ser Thr Ile Ile 
1               5                   10  


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  55

Ala Pro Asn Pro Asn Arg Phe Val Ile 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  56

Trp Leu Lys Ile Lys Arg Asp Tyr Leu 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  57

Ser Ile Ile Asp Leu Ile Asp Glu Tyr 
1               5                   


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  58

Cys Ile Asp Gly Lys Trp Asn Pro Ile Leu Pro Thr Cys Val Arg 
1               5                   10                  15  


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  59

Ser Glu Val Lys Phe Lys Tyr Val Leu 
1               5                   


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  60

Thr Lys Tyr Phe Arg Cys Glu Glu Lys Asn Gly Asn Thr Ser Trp 
1               5                   10                  15  


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  61

Asp Glu Ile Lys Cys Pro Asn Leu Asn 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  62

His Asp Val Tyr Gly Val Ser Asn Phe 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  63

Asp Glu Val Ala Ser Thr His Asp Trp 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  64

Tyr Glu Phe Arg Lys Val Lys Ser Tyr 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  65

Glu Glu Arg His Ile Phe Leu Asp Tyr 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  66

Leu Glu Asn Gly Ala Ile Arg Ile Tyr 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  67

Glu Glu Ile Pro Asp Phe Ala Phe Tyr 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  68

Asp Asp Val Ser Arg Glu Lys Ser Met 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  69

Ile Glu Gly Glu Leu Glu Ser Leu Ser 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human HLA class I Vaccinia epitope

<400>  70

Ala Glu Leu Thr Ile Gly Val Asn Tyr 
1               5                   


