                        б

<110>  зҩɷ޹˾
       
<120>  ıЧӦܵFc弰ںϵ

<130>  P2019082WO01
<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  1288
<212>  DNA
<213>  ˹

<220>
<223>  R0354Ļ

<400>  1
ccgcaagctt gccaccatgg gatggtcatg cataatactc tttcttgtgg ctactgctac       60

cggggttcac tcttcccccg gccagggcac ccagagcgag aactcttgta cccacttccc      120

cggcaacctg cccaatatgc tgcgggatct gagagacgcc ttcagcagag tgaagacctt      180

ctttcagatg aaggaccagc tggataacct gctgctgaag gagagcctgc tggaggattt      240

caagggctac ctgggctgtc aggccctgag cgagatgatc cagttctacc tggaggaggt      300

aatgccacag gccgagaatc aggacccaga catcaaggcc cacgtgaact ctctgggcga      360

gaatctgaag accctgagac tgaggctgag acgctgtcac agattcctgc catgcgagaa      420

caagagcaag gccgtggagc aggtgaagaa cgccttcaat aagctgcagg agaagggcat      480

ctacaaggcc atgtctgagt tcgacatctt tatcaactac atcgaggcct acatgaccat      540

gaagatccgg aacggctctg gctccggcag cggctccgag cccaagagct gcgacaagac      600

ccacacctgc cccccctgcc ccgccccccc cctgctgggc ggcgccagcg tgttcctgtt      660

cccccccaag cccaaggaca ccctgatgat cagccgcacc cccgaggtga cctgcgtggt      720

ggtggccgtg agccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga      780

ggtgcacaac gccaagacca agccccgcga ggagcagtac aacagcacct accgcgtggt      840

gagcgtgctg accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt      900

gagcaacaag gccctgcccg cccccatcga gaagaccatc agcaaggcca agggccagcc      960

ccgcgagccc caggtgtaca ccctgccccc cagccgcgac gagctgacca agaaccaggt     1020

gagcctgacc tgcctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag     1080

caacggccag cccgagaaca actacaagac cacccccccc gtgctggaca gcgacggcag     1140

cttcttcctg tacagcaagc tgaccgtgga caagagccgc tggcagcagg gcaacgtgtt     1200

cagctgcagc gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct     1260

gagccccggc aagtaatgag aattccgg                                        1288


<210>  2
<211>  419
<212>  PRT
<213>  ˹

<220>
<223>  RO354İ

<400>  2

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr 
            20                  25                  30          


His Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala 
        35                  40                  45              


Phe Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn 
    50                  55                  60                  


Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly 
65                  70                  75                  80  


Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met 
                85                  90                  95      


Pro Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser 
            100                 105                 110         


Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His 
        115                 120                 125             


Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys 
    130                 135                 140                 


Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser 
145                 150                 155                 160 


Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys 
                165                 170                 175     


Ile Arg Asn Gly Ser Gly Ser Gly Ser Gly Ser Glu Pro Lys Ser Cys 
            180                 185                 190         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Leu Leu Gly 
        195                 200                 205             


Gly Ala Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    210                 215                 220                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His 
225                 230                 235                 240 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                245                 250                 255     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            260                 265                 270         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        275                 280                 285             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    290                 295                 300                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
305                 310                 315                 320 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                325                 330                 335     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            340                 345                 350         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        355                 360                 365             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    370                 375                 380                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
385                 390                 395                 400 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Lys 
            


<210>  3
<211>  1288
<212>  DNA
<213>  ˹

<220>
<223>  R0355Ļ

<400>  3
ccgcaagctt gccaccatgg gatggtcatg cataatactc tttcttgtgg ctactgctac       60

cggggttcac tcttcccccg gccagggcac ccagagcgag aactcttgta cccacttccc      120

cggcaacctg cccaatatgc tgcgggatct gagagacgcc ttcagcagag tgaagacctt      180

ctttcagatg aaggaccagc tggataacct gctgctgaag gagagcctgc tggaggattt      240

caagggctac ctgggctgtc aggccctgag cgagatgatc cagttctacc tggaggaggt      300

aatgccacag gccgagaatc aggacccaga catcaaggcc cacgtgaact ctctgggcga      360

gaatctgaag accctgagac tgaggctgag acgctgtcac agattcctgc catgcgagaa      420

caagagcaag gccgtggagc aggtgaagaa cgccttcaat aagctgcagg agaagggcat      480

ctacaaggcc atgtctgagt tcgacatctt tatcaactac atcgaggcct acatgaccat      540

gaagatccgg aacggctctg gctccggcag cggctccgag cccaagagct gcgacaagac      600

ccacacctgc cccccctgcc ccgcccccga gctggccggc ggccccagcg tgttcctgtt      660

cccccccaag cccaaggaca ccctgatgat cagccgcacc cccgaggtga cctgcgtggt      720

ggtggacgtg agccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga      780

ggtgcacaac gccaagacca agccccgcga ggagcagtac gccagcacct accgcgtggt      840

gagcgtgctg accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt      900

gagcaacaag gccctgcccg cccccatcga gaagaccatc agcaaggcca agggccagcc      960

ccgcgagccc caggtgtaca ccctgccccc cagccgcgac gagctgacca agaaccaggt     1020

gagcctgacc tgcctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag     1080

caacggccag cccgagaaca actacaagac cacccccccc gtgctggaca gcgacggcag     1140

cttcttcctg tacagcaagc tgaccgtgga caagagccgc tggcagcagg gcaacgtgtt     1200

cagctgcagc gtgatgcacg aggccctgca cgcccactac acccagaaga gcctgagcct     1260

gagccccggc aagtaatgag aattccgg                                        1288


<210>  4
<211>  419
<212>  PRT
<213>  ˹

<220>
<223>  R0355İ

<400>  4

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr 
            20                  25                  30          


His Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala 
        35                  40                  45              


Phe Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn 
    50                  55                  60                  


Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly 
65                  70                  75                  80  


Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met 
                85                  90                  95      


Pro Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser 
            100                 105                 110         


Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His 
        115                 120                 125             


Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys 
    130                 135                 140                 


Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser 
145                 150                 155                 160 


Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys 
                165                 170                 175     


Ile Arg Asn Gly Ser Gly Ser Gly Ser Gly Ser Glu Pro Lys Ser Cys 
            180                 185                 190         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly 
        195                 200                 205             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    210                 215                 220                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
225                 230                 235                 240 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                245                 250                 255     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
            260                 265                 270         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        275                 280                 285             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    290                 295                 300                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
305                 310                 315                 320 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                325                 330                 335     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            340                 345                 350         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        355                 360                 365             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    370                 375                 380                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
385                 390                 395                 400 


His Glu Ala Leu His Ala His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Lys 
            


<210>  5
<211>  1288
<212>  DNA
<213>  ˹

<220>
<223>  R0356Ļ

<400>  5
ccgcaagctt gccaccatgg gatggtcatg cataatactc tttcttgtgg ctactgctac       60

cggggttcac tcttcccccg gccagggcac ccagagcgag aactcttgta cccacttccc      120

cggcaacctg cccaatatgc tgcgggatct gagagacgcc ttcagcagag tgaagacctt      180

ctttcagatg aaggaccagc tggataacct gctgctgaag gagagcctgc tggaggattt      240

caagggctac ctgggctgtc aggccctgag cgagatgatc cagttctacc tggaggaggt      300

aatgccacag gccgagaatc aggacccaga catcaaggcc cacgtgaact ctctgggcga      360

gaatctgaag accctgagac tgaggctgag acgctgtcac agattcctgc catgcgagaa      420

caagagcaag gccgtggagc aggtgaagaa cgccttcaat aagctgcagg agaagggcat      480

ctacaaggcc atgtctgagt tcgacatctt tatcaactac atcgaggcct acatgaccat      540

gaagatccgg aacggctctg gctccggcag cggctccgag cccaagagct gcgacaagac      600

ccacacctgc cccccctgcc ccgcccccga gctggccggc gcccccagcg tgttcctgtt      660

cccccccaag cccaaggaca ccctgatgat cagccgcacc cccgaggtga cctgcgtggt      720

ggtggacgtg agccacgagg accccgaggt gaagttcaac tggtacgtgg acggcgtgga      780

ggtgcacaac gccaagacca agccccgcga ggagcagtac aacagcacct accgcgtggt      840

gagcgtgctg accgtgctgc accaggactg gctgaacggc aaggagtaca agtgcaaggt      900

gagcaacaag cagctgcccg cccccatcga gaagaccatc agcaaggcca agggccagcc      960

ccgcgagccc caggtgtaca ccctgccccc cagccgcgac gagctgacca agaaccaggt     1020

gagcctgacc tgcctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag     1080

caacggccag cccgagaaca actacaagac cacccccccc gtgctggaca gcgacggcag     1140

cttcttcctg tacagcaagc tgaccgtgga caagagccgc tggcagcagg gcaacgtgtt     1200

cagctgcagc gtgatgcacg aggccctgca caaccactac acccagaaga gcctgagcct     1260

gagccccggc aagtaatgag aattccgg                                        1288


<210>  6
<211>  419
<212>  PRT
<213>  ˹

<220>
<223>  RO356İ

<400>  6

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr 
            20                  25                  30          


His Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala 
        35                  40                  45              


Phe Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn 
    50                  55                  60                  


Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly 
65                  70                  75                  80  


Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met 
                85                  90                  95      


Pro Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser 
            100                 105                 110         


Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His 
        115                 120                 125             


Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys 
    130                 135                 140                 


Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser 
145                 150                 155                 160 


Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys 
                165                 170                 175     


Ile Arg Asn Gly Ser Gly Ser Gly Ser Gly Ser Glu Pro Lys Ser Cys 
            180                 185                 190         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Ala Gly 
        195                 200                 205             


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    210                 215                 220                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
225                 230                 235                 240 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                245                 250                 255     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            260                 265                 270         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        275                 280                 285             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gln Leu Pro Ala Pro Ile 
    290                 295                 300                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
305                 310                 315                 320 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                325                 330                 335     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            340                 345                 350         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        355                 360                 365             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    370                 375                 380                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
385                 390                 395                 400 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Lys 
            


<210>  7
<211>  1432
<212>  DNA
<213>  ˹

<220>
<223>  R0359VCHEĻ

<400>  7
ccgcaagctt gccaccatgg gatggtcatg cataatactc tttcttgtgg ctactgctac       60

cggggttcac tctcaggtgc agctgcagca gagcggcgcc gagctggtgc gccccggcac      120

cagcgtgaag atgttctgca aggccgccgg ctacaccttc accaacagct ggatcggctg      180

gttccgccag cgccccggcc acggcctgga gtggatcggc gacatctacc ccggcggcgg      240

ctacaccaac tacaacgaga tcttcaaggg caaggccacc ctgaccgccg acaccagcag      300

cagcaccgcc tacatgcagc tgagcagcct gaccagcgag gacagcgcca tctactactg      360

cagccgcggc atccccggct acgccatgga ctactggggc cagggcacca gcgtgaccgt      420

gagcagcgcc tctaccaagg gaccctctgt gtttcctctg gctccctcca gcaagtctac      480

ctctggtgga acagctgccc tgggctgcct ggtcaaggat tactttcctg agcctgtgac      540

cgtgtcctgg aactctggcg ctctgacatc tggcgtgcac acctttccag ctgtgctgca      600

gtcctccggc ctgtactctc tgtcctctgt cgtgaccgtg ccttccagct ctctgggcac      660

ccagacctac atctgcaatg tgaaccacaa gccttccaac accaaggtgg acaagagagt      720

ggaacccaag tcctgcgaca agacccacac ctgtcctcca tgtcctgctc cagaagctga      780

gggcgctcct tccgtgttcc tgtttcctcc aaagcctaag gacaccctga tgatctctcg      840

gacccctgaa gtgacctgcg tggtggtgga tgtgtctcac gaggacccag aagtgaagtt      900

caattggtac gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca      960

gtacaactcc acctacagag tggtgtccgt gctgaccgtg ctgcaccagg attggctgaa     1020

cggcaaagag tacaagtgca aggtgtccaa caaggccctg cctgctccta tcgaaaagac     1080

catctccaag gccaagggcc agcctcgaga accccaggtt tacaccctgc ctccaagccg     1140

ggaagagatg accaagaacc aggtgtccct gacctgcctc gtgaagggct tctacccttc     1200

cgacattgcc gtggaatggg agagcaatgg ccagccagag aacaactaca agacaacccc     1260

tcctgtgctg gactccgacg gctcattctt cctgtactcc aagctgacag tggacaagtc     1320

cagatggcag cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaatca     1380

ctacacacag aagtccctgt ctctgtcccc tggcaagtaa tgagaattcc gg             1432


<210>  8
<211>  467
<212>  PRT
<213>  ˹

<220>
<223>  R0359VCHEİ

<400>  8

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Met Phe Cys Lys Ala Ala Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Ser Trp Ile Gly Trp Phe Arg Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Ile Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Gly Ile Pro Gly Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
                245                 250                 255     


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  9
<211>  748
<212>  DNA
<213>  ˹

<220>
<223>  R0359VCLEĻ

<400>  9
ccgcaagctt gccaccatgg gatggtcatg cataatactc tttcttgtgg ctactgctac       60

cggggttcac tctgacatcg tgatgaccca gagccccagc agcctgaccg tgaccgccgg      120

cgagaaggtg accatgagct gcaagagcag ccagagcctg ctgaacagcg gcgaccagaa      180

gaactacctg acctggtacc agcagaagcc cggccagccc cccaagctgc tgatctactg      240

ggccagcacc ggcgagagcg gcgtgcccga ccgcttcacc ggcagcggca gcgagaccga      300

cttcaccctg accatcagca gcgtgcaggc cgaggacctg gccgtgtact actgccagaa      360

cgactacagc tacccctgga ccttcggcgg cggcaccaag ctggagatca agagaactgt      420

ggccgctcca tccgtcttca tttttccccc tagcgacgaa cagctgaaga gtggcaccgc      480

ctctgtggtc tgtctgctga acaatttcta cccccgtgag gcaaaggtgc agtggaaagt      540

cgataacgcc ctgcagtccg gaaatagcca ggagtctgtg acagaacagg acagtaagga      600

ttcaacttat tctctgtcta gtaccctgac actgtctaaa gctgactacg agaagcacaa      660

agtgtatgca tgcgaagtca cccatcaggg gctgtcatcc cctgtgacaa agtcctttaa      720

tcgcggtgaa tgttaatgag aattccgg                                         748


<210>  10
<211>  239
<212>  PRT
<213>  ˹

<220>
<223>  R0359VCLEİ

<400>  10

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val 
            20                  25                  30          


Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asn Ser Gly Asp Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Gly Glu 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Glu Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
            100                 105                 110         


Cys Gln Asn Asp Tyr Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  11
<211>  57
<212>  DNA
<213>  ˹

<220>
<223>  źĵĻ

<400>  11
atgggatggt catgcataat actctttctt gtggctactg ctaccggggt tcactct          57


<210>  12
<211>  40
<212>  DNA
<213>  ˹

<220>
<223>  1F

<400>  12
ccgcaagctt gccaccatgg gatggtcatg cataatactc                             40


<210>  13
<211>  36
<212>  DNA
<213>  ˹

<220>
<223>  1R

<400>  13
ccggaattct cattacttgc cggggctcag gctcag                                 36


<210>  14
<211>  38
<212>  DNA
<213>  ˹

<220>
<223>  2F

<400>  14
ccgcaagctt gccaccatgg gatggtcatg cataatac                               38


<210>  15
<211>  43
<212>  DNA
<213>  ˹

<220>
<223>  2R

<400>  15
ccggaattct cattacttgc caggggacag agacagggac ttc                         43


<210>  16
<211>  43
<212>  DNA
<213>  ˹

<220>
<223>  3R

<400>  16
ccggaattct cattaacatt caccgcgatt aaaggacttt gtc                         43


<210>  17
<211>  160
<212>  PRT
<213>  

<400>  17

Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210>  18
<211>  418
<212>  PRT
<213>  ˹

<220>
<223>  R0330

<400>  18

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr 
            20                  25                  30          


His Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala 
        35                  40                  45              


Phe Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn 
    50                  55                  60                  


Leu Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly 
65                  70                  75                  80  


Cys Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met 
                85                  90                  95      


Pro Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser 
            100                 105                 110         


Leu Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His 
        115                 120                 125             


Arg Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys 
    130                 135                 140                 


Asn Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser 
145                 150                 155                 160 


Glu Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys 
                165                 170                 175     


Ile Arg Asn Gly Ser Gly Ser Gly Ser Gly Ser Glu Pro Lys Ser Cys 
            180                 185                 190         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
        195                 200                 205             


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    210                 215                 220                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
225                 230                 235                 240 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                245                 250                 255     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            260                 265                 270         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        275                 280                 285             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    290                 295                 300                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
305                 310                 315                 320 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                325                 330                 335     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            340                 345                 350         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        355                 360                 365             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    370                 375                 380                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
385                 390                 395                 400 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly 


<210>  19
<211>  1270
<212>  DNA
<213>  ˹

<220>
<223>  R0330

<400>  19
ccgcaagctt gccaccatgg gatggtcatg cataatactc tttcttgtgg ctactgctac       60

cggggttcac tcttcccccg gccagggcac ccagagcgag aactcttgta cccacttccc      120

cggcaacctg cccaatatgc tgcgggatct gagagacgcc ttcagcagag tgaagacctt      180

ctttcagatg aaggaccagc tggataacct gctgctgaag gagagcctgc tggaggattt      240

caagggctac ctgggctgtc aggccctgag cgagatgatc cagttctacc tggaggaggt      300

aatgccacag gccgagaatc aggacccaga catcaaggcc cacgtgaact ctctgggcga      360

gaatctgaag accctgagac tgaggctgag acgctgtcac agattcctgc catgcgagaa      420

caagagcaag gccgtggagc aggtgaagaa cgccttcaat aagctgcagg agaagggcat      480

ctacaaggcc atgtctgagt tcgacatctt tatcaactac atcgaggcct acatgaccat      540

gaagatccgg aacggctctg gctccggcag cggctccgaa cccaagtcct gcgacaagac      600

ccacacctgt cctccatgtc ctgctccaga agctgagggc gctccttccg tgttcctgtt      660

tcctccaaag cctaaggaca ccctgatgat ctctcggacc cctgaagtga cctgcgtggt      720

ggtggatgtg tctcacgagg acccagaagt gaagttcaat tggtacgtgg acggcgtgga      780

agtgcacaac gccaagacca agcctagaga ggaacagtac aactccacct acagagtggt      840

gtccgtgctg accgtgctgc accaggattg gctgaacggc aaagagtaca agtgcaaggt      900

gtccaacaag gccctgcctg ctcctatcga aaagaccatc tccaaggcca agggccagcc      960

tcgagaaccc caggtttaca ccctgcctcc aagccgggaa gagatgacca agaaccaggt     1020

gtccctgacc tgcctcgtga agggcttcta cccttccgac attgccgtgg aatgggagag     1080

caatggccag ccagagaaca actacaagac aacccctcct gtgctggact ccgacggctc     1140

attcttcctg tactccaagc tgacagtgga caagtccaga tggcagcagg gcaacgtgtt     1200

ctcctgctcc gtgatgcacg aggccctgca caatcactac acacagaagt ccctgtctct     1260

gtcccctggc                                                            1270


<210>  20
<211>  696
<212>  DNA
<213>  ˹

<220>
<223>  Fc

<400>  20
gagcccaaga gctgcgacaa gacccacacc tgccccccct gccccgcccc ccccctgctg       60

ggcggcgcca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagccgc      120

acccccgagg tgacctgcgt ggtggtggcc gtgagccacg aggaccccga ggtgaagttc      180

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg cgaggagcag      240

tacaacagca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac      300

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgcccccat cgagaagacc      360

atcagcaagg ccaagggcca gccccgcgag ccccaggtgt acaccctgcc ccccagccgc      420

gacgagctga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctaccccagc      480

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc      540

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc      600

cgctggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac      660

tacacccaga agagcctgag cctgagcccc ggcaag                                696


<210>  21
<211>  696
<212>  DNA
<213>  ˹

<220>
<223>  Fc

<400>  21
gagcccaaga gctgcgacaa gacccacacc tgccccccct gccccgcccc cgagctggcc       60

ggcggcccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagccgc      120

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      180

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg cgaggagcag      240

tacgccagca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac      300

ggcaaggagt acaagtgcaa ggtgagcaac aaggccctgc ccgcccccat cgagaagacc      360

atcagcaagg ccaagggcca gccccgcgag ccccaggtgt acaccctgcc ccccagccgc      420

gacgagctga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctaccccagc      480

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc      540

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc      600

cgctggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacgcccac      660

tacacccaga agagcctgag cctgagcccc ggcaag                                696


<210>  22
<211>  696
<212>  DNA
<213>  ˹

<220>
<223>  Fc

<400>  22
gagcccaaga gctgcgacaa gacccacacc tgccccccct gccccgcccc cgagctggcc       60

ggcgccccca gcgtgttcct gttccccccc aagcccaagg acaccctgat gatcagccgc      120

acccccgagg tgacctgcgt ggtggtggac gtgagccacg aggaccccga ggtgaagttc      180

aactggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg cgaggagcag      240

tacaacagca cctaccgcgt ggtgagcgtg ctgaccgtgc tgcaccagga ctggctgaac      300

ggcaaggagt acaagtgcaa ggtgagcaac aagcagctgc ccgcccccat cgagaagacc      360

atcagcaagg ccaagggcca gccccgcgag ccccaggtgt acaccctgcc ccccagccgc      420

gacgagctga ccaagaacca ggtgagcctg acctgcctgg tgaagggctt ctaccccagc      480

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc      540

cccgtgctgg acagcgacgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc      600

cgctggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac      660

tacacccaga agagcctgag cctgagcccc ggcaag                                696


<210>  23
<211>  40
<212>  DNA
<213>  ˹

<220>
<223>  R0330

<400>  23
ccggaattct cattagccag gggacagaga cagggacttc                             40
