                         SEQUENCE LISTING

<110>  UNIVERSITE DE TOURS
       CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
 
<120>  NOUVEAUX ANTICORPS MONOCLONAUX THERAPEUTIQUES HUMAINS ET LEURS 
       UTILISATIONS

<130>  WOB 19 AC TOU APR3

<150>  FR1911722
<151>  2019-10-18

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  254
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(24)

<220>
<221>  PROPEP
<222>  (25)..(26)
<223>  di-propeptide cliv par la cathepsine C

<220>
<221>  mat_peptide
<222>  (27)..(247)
<223>  squence N-term de la protinase 3 (PR3) native active

<220>
<221>  PROPEP
<222>  (248)..(254)
<223>  pro-peptide en C-terminal

<400>  1

Arg His Arg Pro Pro Ser Pro Ala Leu Ala Ser Val Leu Leu Ala Leu 
    -25                 -20                 -15                 


Leu Leu Ser Gly Ala Ala Arg Ala Ala Glu Ile Val Gly Gly His Glu 
-10                 -5              -1  1               5       


Ala Gln Pro His Ser Arg Pro Tyr Met Ala Ser Leu Gln Met Arg Gly 
            10                  15                  20          


Asn Pro Gly Ser His Phe Cys Gly Gly Thr Leu Ile His Pro Ser Phe 
        25                  30                  35              


Val Leu Thr Ala Ala His Cys Leu Arg Asp Ile Pro Gln Arg Leu Val 
    40                  45                  50                  


Asn Val Val Leu Gly Ala His Asn Val Arg Thr Gln Glu Pro Thr Gln 
55                  60                  65                  70  


Gln His Phe Ser Val Ala Gln Val Phe Leu Asn Asn Tyr Asp Ala Glu 
                75                  80                  85      


Asn Lys Leu Asn Asp Val Leu Leu Ile Gln Leu Ser Ser Pro Ala Asn 
            90                  95                  100         


Leu Ser Ala Ser Val Ala Thr Val Gln Leu Pro Gln Gln Asp Gln Pro 
        105                 110                 115             


Val Pro His Gly Thr Gln Cys Leu Ala Met Gly Trp Gly Arg Val Gly 
    120                 125                 130                 


Ala His Asp Pro Pro Ala Gln Val Leu Gln Glu Leu Asn Val Thr Val 
135                 140                 145                 150 


Val Thr Phe Phe Cys Arg Pro His Asn Ile Cys Thr Phe Val Pro Arg 
                155                 160                 165     


Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser Gly Gly Pro Leu Ile Cys 
            170                 175                 180         


Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe Val Ile Trp Gly Cys Ala 
        185                 190                 195             


Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg Val Ala Leu Tyr Val Asp 
    200                 205                 210                 


Trp Ile Arg Ser Thr Leu Arg Arg Val Glu Ala Lys Gly Pro 
215                 220                 225             


<210>  2
<211>  1374
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1374)
<223>  Anticorps 4C3, chane lourde

<220>
<221>  V_region
<222>  (1)..(381)

<220>
<221>  V_segment
<222>  (1)..(297)

<220>
<221>  D-segment
<222>  (310)..(330)

<220>
<221>  J_segment
<222>  (346)..(381)

<220>
<221>  C_region
<222>  (382)..(1374)

<400>  2
gag gtg cag ctg gta cag tcg ggg act gag gtg aag aag cct ggg tct         48
Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser           
1               5                   10                  15                

tcg gtg aag gtc tcc tgc gag att tcc gga gac gac ttc ttc acc tat         96
Ser Val Lys Val Ser Cys Glu Ile Ser Gly Asp Asp Phe Phe Thr Tyr           
            20                  25                  30                    

ggc gtc agc tgg gtg cgg caa gcc cct gga caa gga ctt gag tgg atg        144
Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg ggg atc gtc ccc atg ttt ggt aca aga aac tac gca cgt aaa ttc        192
Gly Gly Ile Val Pro Met Phe Gly Thr Arg Asn Tyr Ala Arg Lys Phe           
    50                  55                  60                            

cag ggc aga gtc acg att acc gcg gac gac tct acg agc aca gtc cac        240
Gln Gly Arg Val Thr Ile Thr Ala Asp Asp Ser Thr Ser Thr Val His           
65                  70                  75                  80            

att gcc ctg acc agc ctg aca ttt gac gac acg gcc att tat tat tgt        288
Ile Ala Leu Thr Ser Leu Thr Phe Asp Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aga gag gga gtc ccc gac tat tgt act aat ggt gtc tgc cac tcc        336
Ala Arg Glu Gly Val Pro Asp Tyr Cys Thr Asn Gly Val Cys His Ser           
            100                 105                 110                   

tac gtc aaa tac tgg ggc cag gga acc ctg gtc acc gtc tcc tca gct        384
Tyr Val Lys Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala           
        115                 120                 125                       

agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc        432
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser           
    130                 135                 140                           

acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc        480
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe           
145                 150                 155                 160           

ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc        528
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly           
                165                 170                 175               

gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc        576
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu           
            180                 185                 190                   

agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac        624
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr           
        195                 200                 205                       

atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag aga        672
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg           
    210                 215                 220                           

gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca        720
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro           
225                 230                 235                 240           

gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa        768
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys           
                245                 250                 255               

ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg        816
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val           
            260                 265                 270                   

gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac        864
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr           
        275                 280                 285                       

gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag        912
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu           
    290                 295                 300                           

cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac        960
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His           
305                 310                 315                 320           

cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa       1008
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys           
                325                 330                 335               

gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag       1056
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln           
            340                 345                 350                   

ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg       1104
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met           
        355                 360                 365                       

acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc       1152
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro           
    370                 375                 380                           

agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac       1200
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn           
385                 390                 395                 400           

tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc       1248
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu           
                405                 410                 415               

tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc       1296
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val           
            420                 425                 430                   

ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag       1344
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln           
        435                 440                 445                       

aag agc ctc tcc ctg tct ccg ggt aaa tga                               1374
Lys Ser Leu Ser Leu Ser Pro Gly Lys                                       
    450                 455                                               


<210>  3
<211>  457
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, chane lourde

<400>  3

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ile Ser Gly Asp Asp Phe Phe Thr Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Val Pro Met Phe Gly Thr Arg Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Asp Ser Thr Ser Thr Val His 
65                  70                  75                  80  


Ile Ala Leu Thr Ser Leu Thr Phe Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Pro Asp Tyr Cys Thr Asn Gly Val Cys His Ser 
            100                 105                 110         


Tyr Val Lys Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  4
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  Anticorps 4C3, rgion constante de la chane lourde

<400>  4
gct agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu           
225                 230                 235                 240           

atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  5
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, rgion constante de la chane lourde

<400>  5

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  6
<211>  381
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(381)
<223>  Anticorps 4C3, rgion variable de la chane lourde

<400>  6
gag gtg cag ctg gta cag tcg ggg act gag gtg aag aag cct ggg tct         48
Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser           
1               5                   10                  15                

tcg gtg aag gtc tcc tgc gag att tcc gga gac gac ttc ttc acc tat         96
Ser Val Lys Val Ser Cys Glu Ile Ser Gly Asp Asp Phe Phe Thr Tyr           
            20                  25                  30                    

ggc gtc agc tgg gtg cgg caa gcc cct gga caa gga ctt gag tgg atg        144
Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg ggg atc gtc ccc atg ttt ggt aca aga aac tac gca cgt aaa ttc        192
Gly Gly Ile Val Pro Met Phe Gly Thr Arg Asn Tyr Ala Arg Lys Phe           
    50                  55                  60                            

cag ggc aga gtc acg att acc gcg gac gac tct acg agc aca gtc cac        240
Gln Gly Arg Val Thr Ile Thr Ala Asp Asp Ser Thr Ser Thr Val His           
65                  70                  75                  80            

att gcc ctg acc agc ctg aca ttt gac gac acg gcc att tat tat tgt        288
Ile Ala Leu Thr Ser Leu Thr Phe Asp Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aga gag gga gtc ccc gac tat tgt act aat ggt gtc tgc cac tcc        336
Ala Arg Glu Gly Val Pro Asp Tyr Cys Thr Asn Gly Val Cys His Ser           
            100                 105                 110                   

tac gtc aaa tac tgg ggc cag gga acc ctg gtc acc gtc tcc tca            381
Tyr Val Lys Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  7
<211>  127
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, rgion variable de la chane lourde

<400>  7

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ile Ser Gly Asp Asp Phe Phe Thr Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Val Pro Met Phe Gly Thr Arg Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Asp Ser Thr Ser Thr Val His 
65                  70                  75                  80  


Ile Ala Leu Thr Ser Leu Thr Phe Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Pro Asp Tyr Cys Thr Asn Gly Val Cys His Ser 
            100                 105                 110         


Tyr Val Lys Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  8
<211>  297
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(297)
<223>  Anticorps 4C3, rgion V de la rgion variable de la chane lourde

<400>  8
gag gtg cag ctg gta cag tcg ggg act gag gtg aag aag cct ggg tct         48
Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser           
1               5                   10                  15                

tcg gtg aag gtc tcc tgc gag att tcc gga gac gac ttc ttc acc tat         96
Ser Val Lys Val Ser Cys Glu Ile Ser Gly Asp Asp Phe Phe Thr Tyr           
            20                  25                  30                    

ggc gtc agc tgg gtg cgg caa gcc cct gga caa gga ctt gag tgg atg        144
Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg ggg atc gtc ccc atg ttt ggt aca aga aac tac gca cgt aaa ttc        192
Gly Gly Ile Val Pro Met Phe Gly Thr Arg Asn Tyr Ala Arg Lys Phe           
    50                  55                  60                            

cag ggc aga gtc acg att acc gcg gac gac tct acg agc aca gtc cac        240
Gln Gly Arg Val Thr Ile Thr Ala Asp Asp Ser Thr Ser Thr Val His           
65                  70                  75                  80            

att gcc ctg acc agc ctg aca ttt gac gac acg gcc att tat tat tgt        288
Ile Ala Leu Thr Ser Leu Thr Phe Asp Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aga gag                                                            297
Ala Arg Glu                                                               
                                                                          


<210>  9
<211>  99
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, rgion V de la rgion variable de la chane lourde

<400>  9

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ile Ser Gly Asp Asp Phe Phe Thr Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Val Pro Met Phe Gly Thr Arg Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Asp Ser Thr Ser Thr Val His 
65                  70                  75                  80  


Ile Ala Leu Thr Ser Leu Thr Phe Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu 
            


<210>  10
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(21)
<223>  Anticorps 4C3, rgion D de la rgion variable de la chane lourde

<400>  10
tat tgt act aat ggt gtc tgc                                             21
Tyr Cys Thr Asn Gly Val Cys                                               
1               5                                                         


<210>  11
<211>  7
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, rgion D de la rgion variable de la chane lourde

<400>  11

Tyr Cys Thr Asn Gly Val Cys 
1               5           


<210>  12
<211>  36
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(36)
<223>  Anticorps 4C3, rgion J de la rgion variable de la chane lourde

<400>  12
tac tgg ggc cag gga acc ctg gtc acc gtc tcc tca                         36
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
1               5                   10                                    


<210>  13
<211>  12
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, rgion J de la rgion variable de la chane lourde

<400>  13

Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10          


<210>  14
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(24)
<223>  Anticorps 4C3, CDR1 de la chane lourde

<400>  14
gga gac gac ttc ttc acc tat ggc                                         24
Gly Asp Asp Phe Phe Thr Tyr Gly                                           
1               5                                                         


<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, CDR1 de la chane lourde

<400>  15

Gly Asp Asp Phe Phe Thr Tyr Gly 
1               5               


<210>  16
<211>  24
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(24)
<223>  Anticorps 4C3, CDR2 de la chane lourde

<400>  16
atc gtc ccc atg ttt ggt aca aga                                         24
Ile Val Pro Met Phe Gly Thr Arg                                           
1               5                                                         


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, CDR2 de la chane lourde

<400>  17

Ile Val Pro Met Phe Gly Thr Arg 
1               5               


<210>  18
<211>  60
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(60)
<223>  Anticorps 4C3, CDR3 de la chane lourde

<400>  18
gcg aga gag gga gtc ccc gac tat tgt act aat ggt gtc tgc cac tcc         48
Ala Arg Glu Gly Val Pro Asp Tyr Cys Thr Asn Gly Val Cys His Ser           
1               5                   10                  15                

tac gtc aaa tac                                                         60
Tyr Val Lys Tyr                                                           
            20                                                            


<210>  19
<211>  20
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, CDR3 de la chane lourde

<400>  19

Ala Arg Glu Gly Val Pro Asp Tyr Cys Thr Asn Gly Val Cys His Ser 
1               5                   10                  15      


Tyr Val Lys Tyr 
            20  


<210>  20
<211>  645
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(645)
<223>  Anticorps 4C3, chane lgre

<220>
<221>  V_region
<222>  (1)..(324)

<220>
<221>  V_segment
<222>  (1)..(285)

<220>
<221>  J_segment
<222>  (287)..(321)

<220>
<221>  C_region
<222>  (325)..(645)

<400>  20
gac atc cag atg acc cag tct cct ccc acc ctg tct gct tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Pro Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gcc agt cag agt att agt gac tgg         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Trp           
            20                  25                  30                    

ttg gcc tgg tat cag cag aaa cca ggg aaa cct cct cag ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Gln Leu Leu Ile           
        35                  40                  45                        

tat aag gcg tct agt tta gaa agt ggg gtc cca tca agg ttc agc ggc        192
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

act gga tct ggg gca gaa ttc act ctc acc atc agc agc ctg cag cct        240
Thr Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gac gat tct gca acc tat tat tgc caa cag tat aat agt tac tct aac        288
Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Asn           
                85                  90                  95                

act ttt ggc cag ggg acc aag ctg gag atc aaa cgt acg gtg gct gca        336
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala           
            100                 105                 110                   

cca tct gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga        384
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly           
        115                 120                 125                       

act gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc        432
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala           
    130                 135                 140                           

aaa gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag        480
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln           
145                 150                 155                 160           

gag agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc        528
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser           
                165                 170                 175               

agc acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac        576
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr           
            180                 185                 190                   

gcc tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc        624
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser           
        195                 200                 205                       

ttc aac agg gga gag tgt tag                                            645
Phe Asn Arg Gly Glu Cys                                                   
    210                                                                   


<210>  21
<211>  214
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, chane lgre

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Pro Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  22
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  Anticorps 4C3, rgion constante de la chane lgre

<400>  22
cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  23
<211>  107
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, rgion constante de la chane lgre

<400>  23

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  24
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  Anticorps 4C3, rgion variable de la chane lgre

<400>  24
gac atc cag atg acc cag tct cct ccc acc ctg tct gct tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Pro Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gcc agt cag agt att agt gac tgg         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Trp           
            20                  25                  30                    

ttg gcc tgg tat cag cag aaa cca ggg aaa cct cct cag ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Gln Leu Leu Ile           
        35                  40                  45                        

tat aag gcg tct agt tta gaa agt ggg gtc cca tca agg ttc agc ggc        192
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

act gga tct ggg gca gaa ttc act ctc acc atc agc agc ctg cag cct        240
Thr Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gac gat tct gca acc tat tat tgc caa cag tat aat agt tac tct aac        288
Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Asn           
                85                  90                  95                

act ttt ggc cag ggg acc aag ctg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                               
            100                 105                                       


<210>  25
<211>  107
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, rgion variable de la chane lgre

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Pro Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  285
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(285)
<223>  Anticorps 4C3, rgion V de la rgion variable de la chane lgre

<400>  26
gac atc cag atg acc cag tct cct ccc acc ctg tct gct tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Pro Thr Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gcc agt cag agt att agt gac tgg         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Trp           
            20                  25                  30                    

ttg gcc tgg tat cag cag aaa cca ggg aaa cct cct cag ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Gln Leu Leu Ile           
        35                  40                  45                        

tat aag gcg tct agt tta gaa agt ggg gtc cca tca agg ttc agc ggc        192
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

act gga tct ggg gca gaa ttc act ctc acc atc agc agc ctg cag cct        240
Thr Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gac gat tct gca acc tat tat tgc caa cag tat aat agt tac tct            285
Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser               
                85                  90                  95                


<210>  27
<211>  95
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, rgion V de la rgion variable de la chane lgre

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Pro Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser 
                85                  90                  95  


<210>  28
<211>  36
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(36)
<223>  Anticorps 4C3, rgion J de la rgion variable de la chane lgre

<400>  28
aac act ttt ggc cag ggg acc aag ctg gag atc aaa                         36
Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                           
1               5                   10                                    


<210>  29
<211>  12
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, rgion J de la rgion variable de la chane lgre

<400>  29

Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10          


<210>  30
<211>  18
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(18)
<223>  Anticorps 4C3, CDR1 de la chane lgre

<400>  30
cag agt att agt gac tgg                                                 18
Gln Ser Ile Ser Asp Trp                                                   
1               5                                                         


<210>  31
<211>  6
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, CDR1 de la chane lgre

<400>  31

Gln Ser Ile Ser Asp Trp 
1               5       


<210>  32
<211>  9
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(9)
<223>  Anticorps 4C3, CDR2 de la chane lgre

<400>  32
aag gcg tct                                                              9
Lys Ala Ser                                                               
1                                                                         


<210>  33
<211>  3
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Anticorps 4C3, CDR2 de la chane lgre

<400>  33

Lys Ala Ser 
1           


<210>  34
<211>  27
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(27)
<223>  Anticorps 4C3, CDR3 de la chane lgre

<400>  34
caa cag tat aat agt tac tct aac act                                     27
Gln Gln Tyr Asn Ser Tyr Ser Asn Thr                                       
1               5                                                         


<210>  35
<211>  9
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3, CDR3 de la chane lgre

<400>  35

Gln Gln Tyr Asn Ser Tyr Ser Asn Thr 
1               5                   


<210>  36
<211>  1374
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1374)
<223>  Anticorps 4C3 recombinant (r4C3), chane lourde

<220>
<221>  V_region
<222>  (1)..(381)

<220>
<221>  V_segment
<222>  (1)..(297)

<220>
<221>  D-segment
<222>  (310)..(330)

<220>
<221>  J_segment
<222>  (346)..(381)

<220>
<221>  C_region
<222>  (382)..(1374)

<400>  36
gag gtg cag ctg gta cag tcg ggg act gag gtg aag aag cct ggg tct         48
Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser           
1               5                   10                  15                

tcg gtg aag gtc tcc tgc gag att tcc gga gac gac ttc ttc acc tat         96
Ser Val Lys Val Ser Cys Glu Ile Ser Gly Asp Asp Phe Phe Thr Tyr           
            20                  25                  30                    

ggc gtc agc tgg gtg cgg caa gcc cct gga caa gga ctt gag tgg atg        144
Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg ggg atc gtc ccc atg ttt ggt aca aga aac tac gca cgt aaa ttc        192
Gly Gly Ile Val Pro Met Phe Gly Thr Arg Asn Tyr Ala Arg Lys Phe           
    50                  55                  60                            

cag ggc aga gtc acg att acc gcg gac gac tct acg agc aca gtc cac        240
Gln Gly Arg Val Thr Ile Thr Ala Asp Asp Ser Thr Ser Thr Val His           
65                  70                  75                  80            

att gcc ctg acc agc ctg aca ttt gac gac acg gcc att tat tat tgt        288
Ile Ala Leu Thr Ser Leu Thr Phe Asp Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aga gag gga gtc ccc gac tat tgt act aat ggt gtc tgc cac tcc        336
Ala Arg Glu Gly Val Pro Asp Tyr Cys Thr Asn Gly Val Cys His Ser           
            100                 105                 110                   

tac gtc aaa tac tgg ggc cag gga acc ctg gtc acc gtc tcc tca gct        384
Tyr Val Lys Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala           
        115                 120                 125                       

agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc        432
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser           
    130                 135                 140                           

acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc        480
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe           
145                 150                 155                 160           

ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc        528
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly           
                165                 170                 175               

gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc        576
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu           
            180                 185                 190                   

agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc tac        624
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr           
        195                 200                 205                       

atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag aaa        672
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys           
    210                 215                 220                           

gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca        720
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro           
225                 230                 235                 240           

gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa        768
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys           
                245                 250                 255               

ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg        816
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val           
            260                 265                 270                   

gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac        864
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr           
        275                 280                 285                       

gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag        912
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu           
    290                 295                 300                           

cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac        960
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His           
305                 310                 315                 320           

cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa       1008
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys           
                325                 330                 335               

gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag       1056
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln           
            340                 345                 350                   

ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg       1104
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met           
        355                 360                 365                       

acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc       1152
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro           
    370                 375                 380                           

agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac       1200
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn           
385                 390                 395                 400           

tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc       1248
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu           
                405                 410                 415               

tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc       1296
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val           
            420                 425                 430                   

ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg cag       1344
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln           
        435                 440                 445                       

aag agc ctc tcc ctg tct ccg ggt aaa tga                               1374
Lys Ser Leu Ser Leu Ser Pro Gly Lys                                       
    450                 455                                               


<210>  37
<211>  457
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3 recombinant (r4C3), chane lourde

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ile Ser Gly Asp Asp Phe Phe Thr Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Val Pro Met Phe Gly Thr Arg Asn Tyr Ala Arg Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Asp Ser Thr Ser Thr Val His 
65                  70                  75                  80  


Ile Ala Leu Thr Ser Leu Thr Phe Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Pro Asp Tyr Cys Thr Asn Gly Val Cys His Ser 
            100                 105                 110         


Tyr Val Lys Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  38
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(993)
<223>  Anticorps 4C3 recombinant (r4C3), rgion constante de la chane 
       lourde

<400>  38
gct agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu           
225                 230                 235                 240           

atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  39
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Anticorps 4C3 recombinant (r4C3), rgion constante de la chane 
       lourde

<400>  39

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 4C3_3.2

<400>  40

Thr Phe Phe Cys Arg Pro His Asn Ile Cys Thr Phe Val Pro Arg 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 4C3_4.1

<400>  41

Gly Thr Gln Cys Leu Ala Met Gly Trp Gly Arg Val Gly Ala His 
1               5                   10                  15  


<210>  42
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  42

Ile Val Gly Gly His Glu Ala Gln Pro His Ser Arg Pro Tyr Met Ala 
1               5                   10                  15      


Ser Leu Gln Met Arg Gly Asn Pro Gly Ser His Phe Cys Gly Gly Thr 
            20                  25                  30          


Leu Ile His Pro Ser Phe Val Leu Thr Ala Ala His Cys Leu Arg Asp 
        35                  40                  45              


Ile Pro Gln Arg Leu Val Asn Val Val Leu Gly Ala His Asn Val Arg 
    50                  55                  60                  


Thr Gln Glu Pro Thr Gln Gln His Phe Ser Val Ala Gln Val Phe Leu 
65                  70                  75                  80  


Asn Asn Tyr Asp Ala Glu Asn Lys Leu Asn Asp Val Leu Leu Ile Gln 
                85                  90                  95      


Leu Ser Ser Pro Ala Asn Leu Ser Ala Ser Val Ala Thr Val Gln Leu 
            100                 105                 110         


Pro Gln Gln Asp Gln Pro Val Pro His Gly Thr Gln Cys Leu Ala Met 
        115                 120                 125             


Gly Trp Gly Arg Val Gly Ala His Asp Pro Pro Ala Gln Val Leu Gln 
    130                 135                 140                 


Glu Leu Asn Val Thr Val Val Thr Phe Phe Cys Arg Pro His Asn Ile 
145                 150                 155                 160 


Cys Thr Phe Val Pro Arg Arg Lys Ala Gly Ile Cys Phe Gly Asp Ser 
                165                 170                 175     


Gly Gly Pro Leu Ile Cys Asp Gly Ile Ile Gln Gly Ile Asp Ser Phe 
            180                 185                 190         


Val Ile Trp Gly Cys Ala Thr Arg Leu Phe Pro Asp Phe Phe Thr Arg 
        195                 200                 205             


Val Ala Leu Tyr Val Asp Trp Ile Arg Ser Thr Leu Arg 
    210                 215                 220     


