                               SEQUENCE LISTING

<110> MODERNA TX, INC.
      THE BOARD OF REGENTS FOR THE UNIVERSITY OF NEBRASKA
 
<120> MRNAS ENCODING GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR 
      FOR TREATING PARKINSON'S DISEASE

<130> M2180-7002WO

<140>
<141>

<150> 63/013,139
<151> 2020-04-21

<150> 62/915,317
<151> 2019-10-15

<160> 189   

<170> PatentIn version 3.5

<210> 1
<211> 127
<212> PRT
<213> Homo sapiens

<400> 1
Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210> 2
<211> 432
<212> RNA
<213> Homo sapiens

<400> 2
auguggcugc agagccugcu gcucuugggc acuguggccu gcagcaucuc ugcacccgcc       60

cgcucgccca gccccagcac gcagcccugg gagcauguga augccaucca ggaggcccgg      120

cgucuccuga accugaguag agacacugcu gcugagauga augaaacagu agaagucauc      180

ucagaaaugu uugaccucca ggagccgacc ugccuacaga cccgccugga gcuguacaag      240

cagggccugc ggggcagccu caccaagcuc aagggccccu ugaccaugau ggccagccac      300

uacaagcagc acugcccucc aaccccggaa acuuccugug caacccagau uaucaccuuu      360

gaaaguuuca aagagaaccu gaaggacuuu cugcuuguca uccccuuuga cugcugggag      420

ccaguccagg ag                                                          432


<210> 3
<211> 788
<212> RNA
<213> Homo sapiens

<400> 3
aguacacaga gagaaaggcu aaaguucucu ggaggaugug gcugcagagc cugcugcucu       60

ugggcacugu ggccugcagc aucucugcac ccgcccgcuc gcccagcccc agcacgcagc      120

ccugggagca ugugaaugcc auccaggagg cccggcgucu ccugaaccug aguagagaca      180

cugcugcuga gaugaaugaa acaguagaag ucaucucaga aauguuugac cuccaggagc      240

cgaccugccu acagacccgc cuggagcugu acaagcaggg ccugcggggc agccucacca      300

agcucaaggg ccccuugacc augauggcca gccacuacaa gcagcacugc ccuccaaccc      360

cggaaacuuc cugugcaacc cagauuauca ccuuugaaag uuucaaagag aaccugaagg      420

acuuucugcu ugucaucccc uuugacugcu gggagccagu ccaggaguga gaccggccag      480

augaggcugg ccaagccggg gagcugcucu cucaugaaac aagagcuaga aacucaggau      540

ggucaucuug gagggaccaa ggggugggcc acagccaugg ugggaguggc cuggaccugc      600

ccugggccac acugacccug auacaggcau ggcagaagaa ugggaauauu uuauacugac      660

agaaaucagu aauauuuaua uauuuauauu uuuaaaauau uuauuuauuu auuuauuuaa      720

guucauauuc cauauuuauu caagauguuu uaccguaaua auuauuauua aaaauaugcu      780

ucuacuug                                                               788


<210> 4
<211> 423
<212> RNA
<213> Mus sp.

<400> 4
auguggcuuc agaaucucuu guuucuugga aucgucgugu acagccuguc agccccaacu       60

agaucgccua ucacugugac gcgcccgugg aagcacgugg aagccaucaa ggaggcucug      120

aaucugcucg acgauaugcc agugacccug aacgaggaag ucgaaguggu guccaacgaa      180

uuuuccuuca agaaguugac cuguguucag acccggcuga agauuuucga gcagggccuc      240

aggggaaacu ucaccaaacu gaagggugca cugaacauga ccgccagcua cuaccagacc      300

uauugcccuc cgacuccgga aacugauugc gagacucaag ucaccaccua cgcggacuuc      360

aucgacucgc ucaagacguu ccugacugac auccccuucg agugcaagaa gccggggcag      420

aaa                                                                    423


<210> 5
<211> 1033
<212> RNA
<213> Mus sp.

<400> 5
ggucagacug cccaggcagg gugggaaagg ccuuuaaagc agcccgcagg ugggcugcca       60

guucuuggaa gggcuuauua augaaaaccc cccaagccug acaaccuggg ggaaggcuca      120

cuggccccau guauagcuga uaagggccag gagauuccac aacucaggua guucccccgc      180

cccccuggag uucugugguc accauuaauc auuuccucua acuguguaua uaagagcucu      240

uuugcaguga gcccaguacu cagagagaaa ggcuaagguc cugaggagga uguggcugca      300

gaauuuacuu uuccugggca uuguggucua cagccucuca gcacccaccc gcucacccau      360

cacugucacc cggccuugga agcauguaga ggccaucaaa gaagcccuga accuccugga      420

ugacaugccu gucacguuga augaagaggu agaagucguc ucuaacgagu ucuccuucaa      480

gaagcuaaca ugugugcaga cccgccugaa gauauucgag cagggucuac ggggcaauuu      540

caccaaacuc aagggcgccu ugaacaugac agccagcuac uaccagacau acugcccccc      600

aacuccggaa acggacugug aaacacaagu uaccaccuau gcggauuuca uagacagccu      660

uaaaaccuuu cugacugaua uccccuuuga augcaaaaaa ccaggccaaa aaugaggaag      720

cccaggccag cucugaaucc agcuucucag acugcugcuu uugugccugc guaaugagcc      780

aggaacuugg aauuucugcc uuaaagggac caagagaugu ggcacagcca caguuggaag      840

gcaguauagc ccucugaaaa cgcugacuca gcuuggacag cggaagacaa acgagagaua      900

uuuucuacug auagggacca uuauauuuau uuauauauuu auauuuuuua aauauuuauu      960

uauuuauuua uuuauuuuug caacucuauu uauugagaau gucuuaccag aauaauaaau     1020

uauuaaaacu uuu                                                        1033


<210> 6
<211> 432
<212> RNA
<213> Rattus sp.

<400> 6
auguggcugc agaaccugcu guuccugggc aucguggugu acagcuucag cgccccuacc       60

agaagcccua acccugugac cagaccuugg aagcacgugg acgccaucaa ggaggcccug      120

agccugcuga acgacaugag agcccuggag aacgagaaga acgaggacgu ggacaucauc      180

agcaacgagu ucagcaucca gagaccuacc ugcgugcaga ccagacugaa gcuguacaag      240

cagggccuga gaggcaaccu gaccaagcug aacggcgccc ugaccaugau cgccagccac      300

uaccagacca acugcccucc uaccccugag accgacugcg agaucgaggu gaccaccuuc      360

gaggacuuca ucaagaaccu gaagggcuuc cuguucgaca ucccuuucga cugcuggaag      420

ccugugcaga ag                                                          432


<210> 7
<211> 441
<212> RNA
<213> Rattus sp.

<400> 7
auguggcugc agaauuuacu uuuccugggc auuguggucu acaguuucuc agcacccacc       60

cgcucgccca acccugucac ccggcccugg aagcauguag augccaucaa agaagcucug      120

agccuccuaa augacaugcg ugcucuggag aacgaaaaga acgaagacgu agacaucauc      180

ucuaaugagu ucuccaucca gaggccgaca ugugugcaga cccgccugaa gcuauacaag      240

cagggucuac ggggcaaccu caccaaacuc aauggcgccu ugaccaugau agccagccac      300

uaccagacga acugcccucc aaccccggaa acugacugug aaauagaagu caccaccuuu      360

gaggauuuca uaaagaaccu uaaaggcuuu cuguuugaua ucccuuuuga cugcuggaag      420

ccgguccaga aaugaggagg c                                                441


<210> 8
<211> 144
<212> PRT
<213> Homo sapiens

<400> 8
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 9
<211> 141
<212> PRT
<213> Mus sp.

<400> 9
Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
    130                 135                 140     


<210> 10
<211> 144
<212> PRT
<213> Rattus sp.

<400> 10
Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Phe 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Asn Pro Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Asp Ala Ile Lys Glu Ala Leu Ser Leu Leu Asn Asp Met Arg Ala 
        35                  40                  45              


Leu Glu Asn Glu Lys Asn Glu Asp Val Asp Ile Ile Ser Asn Glu Phe 
    50                  55                  60                  


Ser Ile Gln Arg Pro Thr Cys Val Gln Thr Arg Leu Lys Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Asn Leu Thr Lys Leu Asn Gly Ala Leu Thr Met 
                85                  90                  95      


Ile Ala Ser His Tyr Gln Thr Asn Cys Pro Pro Thr Pro Glu Thr Asp 
            100                 105                 110         


Cys Glu Ile Glu Val Thr Thr Phe Glu Asp Phe Ile Lys Asn Leu Lys 
        115                 120                 125             


Gly Phe Leu Phe Asp Ile Pro Phe Asp Cys Trp Lys Pro Val Gln Lys 
    130                 135                 140                 


<210> 11
<211> 144
<212> PRT
<213> Macaca fascicularis

<400> 11
Met Trp Leu Gln Gly Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Gly Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Lys Thr Val Glu Val Val Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Ser Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Gln Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Gln Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 12
<211> 432
<212> RNA
<213> Macaca fascicularis

<400> 12
auguggcugc agggccugcu gcugcugggc accguggccu gcagcaucag cgccccugcc       60

agaagcccua gcccuggcac ccagccuugg gagcacguga acgccaucca ggaggccaga      120

agacugcuga accugagcag agacaccgcc gccgagauga acaagaccgu ggagguggug      180

agcgagaugu ucgaccugca ggagccuagc ugccugcaga ccagacugga gcuguacaag      240

cagggccugc agggcagccu gaccaagcug aagggcccuc ugaccaugau ggccagccac      300

uacaagcagc acugcccucc uaccccugag accagcugcg ccacccagau caucaccuuc      360

cagagcuuca aggagaaccu gaaggacuuc cugcugguga ucccuuucga cugcugggag      420

ccugugcagg ag                                                          432


<210> 13

<400> 13
000


<210> 14

<400> 14
000


<210> 15

<400> 15
000


<210> 16

<400> 16
000


<210> 17

<400> 17
000


<210> 18

<400> 18
000


<210> 19

<400> 19
000


<210> 20

<400> 20
000


<210> 21

<400> 21
000


<210> 22

<400> 22
000


<210> 23

<400> 23
000


<210> 24

<400> 24
000


<210> 25
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 25
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            100


<210> 26
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 26
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120


<210> 27

<400> 27
000


<210> 28

<400> 28
000


<210> 29

<400> 29
000


<210> 30

<400> 30
000


<210> 31

<400> 31
000


<210> 32

<400> 32
000


<210> 33

<400> 33
000


<210> 34

<400> 34
000


<210> 35

<400> 35
000


<210> 36

<400> 36
000


<210> 37

<400> 37
000


<210> 38

<400> 38
000


<210> 39

<400> 39
000


<210> 40

<400> 40
000


<210> 41

<400> 41
000


<210> 42

<400> 42
000


<210> 43

<400> 43
000


<210> 44

<400> 44
000


<210> 45

<400> 45
000


<210> 46

<400> 46
000


<210> 47

<400> 47
000


<210> 48

<400> 48
000


<210> 49

<400> 49
000


<210> 50

<400> 50
000


<210> 51

<400> 51
000


<210> 52

<400> 52
000


<210> 53

<400> 53
000


<210> 54

<400> 54
000


<210> 55

<400> 55
000


<210> 56

<400> 56
000


<210> 57

<400> 57
000


<210> 58

<400> 58
000


<210> 59

<400> 59
000


<210> 60

<400> 60
000


<210> 61

<400> 61
000


<210> 62

<400> 62
000


<210> 63

<400> 63
000


<210> 64

<400> 64
000


<210> 65

<400> 65
000


<210> 66

<400> 66
000


<210> 67

<400> 67
000


<210> 68

<400> 68
000


<210> 69

<400> 69
000


<210> 70

<400> 70
000


<210> 71

<400> 71
000


<210> 72

<400> 72
000


<210> 73

<400> 73
000


<210> 74

<400> 74
000


<210> 75

<400> 75
000


<210> 76

<400> 76
000


<210> 77

<400> 77
000


<210> 78

<400> 78
000


<210> 79

<400> 79
000


<210> 80

<400> 80
000


<210> 81

<400> 81
000


<210> 82

<400> 82
000


<210> 83

<400> 83
000


<210> 84

<400> 84
000


<210> 85

<400> 85
000


<210> 86

<400> 86
000


<210> 87
<211> 9
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Kozak sequence"

<400> 87
ccrccaugg                                                                9


<210> 88
<211> 92
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-018 (Upstream UTR) 5' UTR sequence"

<400> 88
ucaagcuuuu ggacccucgu acagaagcua auacgacuca cuauagggaa auaagagaga       60

aaagaagagu aagaagaaau auaagagcca cc                                     92


<210> 89
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-002 (Upstream UTR) sequence"

<400> 89
gggagaucag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 90
<211> 42
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-004 (Upstream UTR) sequence"

<400> 90
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210> 91
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-005 (Upstream UTR) sequence"

<400> 91
gggagaucag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 92
<211> 42
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-007 (Upstream UTR) sequence"

<400> 92
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210> 93
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-008 (Upstream UTR) sequence"

<400> 93
gggaauuaac agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 94
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-009 (Upstream UTR) sequence"

<400> 94
gggaaauuag acagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 95
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-010, Upstream sequence"

<400> 95
gggaaauaag agaguaaaga acaguaagaa gaaauauaag agccacc                     47


<210> 96
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-011 (Upstream UTR) sequence"

<400> 96
gggaaaaaag agagaaaaga agacuaagaa gaaauauaag agccacc                     47


<210> 97
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-012 (Upstream UTR) sequence"

<400> 97
gggaaauaag agagaaaaga agaguaagaa gauauauaag agccacc                     47


<210> 98
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-013 (Upstream UTR) sequence"

<400> 98
gggaaauaag agacaaaaca agaguaagaa gaaauauaag agccacc                     47


<210> 99
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-014 (Upstream UTR) sequence"

<400> 99
gggaaauuag agaguaaaga acaguaagua gaauuaaaag agccacc                     47


<210> 100
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-015 (Upstream UTR) sequence"

<400> 100
gggaaauaag agagaauaga agaguaagaa gaaauauaag agccacc                     47


<210> 101
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-016 (Upstream UTR) sequence"

<400> 101
gggaaauaag agagaaaaga agaguaagaa gaaaauuaag agccacc                     47


<210> 102
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR-017 (Upstream UTR) sequence"

<400> 102
gggaaauaag agagaaaaga agaguaagaa gaaauuuaag agccacc                     47


<210> 103

<400> 103
000


<210> 104
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 104
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 105
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 105
ugauaauagg cuggagccuc gguggcucca uaaaguagga aacacuacac augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 106
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 106
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuuccauaaa guaggaaaca       60

cuacaugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 107
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 107
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagucc       60

auaaaguagg aaacacuaca ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 108
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 108
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu ucuccauaaa guaggaaaca cuacacugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 109
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 109
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccuc cauaaaguag gaaacacuac aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 110
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 110
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaaguucca uaaaguagga      120

aacacuacac ugagugggcg gc                                               142


<210> 111
<211> 164
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 111
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc ccgcauuauu      120

acucacggua cgaguggucu uugaauaaag ucugaguggg cggc                       164


<210> 112
<211> 164
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 112
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc ccgcauuauu      120

acucacggua cgaguggucu uugaauaaag ucugaguggg cggc                       164


<210> 113

<400> 113
000


<210> 114
<211> 87
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-142 sequence"

<400> 114
gacagugcag ucacccauaa aguagaaagc acuacuaaca gcacuggagg guguaguguu       60

uccuacuuua uggaugagug uacugug                                           87


<210> 115
<211> 23
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-142-3p sequence"

<400> 115
uguaguguuu ccuacuuuau gga                                               23


<210> 116
<211> 23
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 142-3p binding site sequence"

<400> 116
uccauaaagu aggaaacacu aca                                               23


<210> 117
<211> 21
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-142-5p sequence"

<400> 117
cauaaaguag aaagcacuac u                                                 21


<210> 118
<211> 21
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-142-5p binding site sequence"

<400> 118
aguagugcuu ucuacuuuau g                                                 21


<210> 119
<211> 85
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-126 sequence"

<400> 119
cgcuggcgac gggacauuau uacuuuuggu acgcgcugug acacuucaaa cucguaccgu       60

gaguaauaau gcgccgucca cggca                                             85


<210> 120
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-126-3p sequence"

<400> 120
ucguaccgug aguaauaaug cg                                                22


<210> 121
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-126-3p binding site sequence"

<400> 121
cgcauuauua cucacgguac ga                                                22


<210> 122
<211> 21
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-126-5p sequence"

<400> 122
cauuauuacu uuugguacgc g                                                 21


<210> 123
<211> 21
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-126-5p binding site sequence"

<400> 123
cgcguaccaa aaguaauaau g                                                 21


<210> 124
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 124
ugauaauag                                                                9


<210> 125
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 125
ugauaguaa                                                                9


<210> 126
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 126
uaaugauag                                                                9


<210> 127
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 127
ugauaauaa                                                                9


<210> 128
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 128
ugauaguag                                                                9


<210> 129
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 129
uaaugauga                                                                9


<210> 130
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 130
uaauaguag                                                                9


<210> 131
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 131
ugaugauga                                                                9


<210> 132
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 132
uaauaauaa                                                                9


<210> 133
<211> 9
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 133
uaguaguag                                                                9


<210> 134
<211> 133
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 134
gcuggagccu cgguggccau gcuucuugcc ccuugggccu ccccccagcc ccuccucccc       60

uuccugcacc cguacccccu ccauaaagua ggaaacacua caguggucuu ugaauaaagu      120

cugagugggc ggc                                                         133


<210> 135
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 146-3p sequence"

<400> 135
ccucugaaau ucaguucuuc ag                                                22


<210> 136
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 146-5p sequence"

<400> 136
ugagaacuga auuccauggg uu                                                22


<210> 137
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 155-3p sequence"

<400> 137
cuccuacaua uuagcauuaa ca                                                22


<210> 138
<211> 23
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 155-5p sequence"

<400> 138
uuaaugcuaa ucgugauagg ggu                                               23


<210> 139
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 16-3p sequence"

<400> 139
ccaguauuaa cugugcugcu ga                                                22


<210> 140
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 16-5p sequence"

<400> 140
uagcagcacg uaaauauugg cg                                                22


<210> 141
<211> 21
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 21-3p sequence"

<400> 141
caacaccagu cgaugggcug u                                                 21


<210> 142
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 21-5p sequence"

<400> 142
uagcuuauca gacugauguu ga                                                22


<210> 143
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 223-3p sequence"

<400> 143
ugucaguuug ucaaauaccc ca                                                22


<210> 144
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 223-5p sequence"

<400> 144
cguguauuug acaagcugag uu                                                22


<210> 145
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 24-3p sequence"

<400> 145
uggcucaguu cagcaggaac ag                                                22


<210> 146
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 24-5p sequence"

<400> 146
ugccuacuga gcugauauca gu                                                22


<210> 147
<211> 21
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 27-3p sequence"

<400> 147
uucacagugg cuaaguuccg c                                                 21


<210> 148
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 27-5p sequence"

<400> 148
agggcuuagc ugcuugugag ca                                                22


<210> 149
<211> 141
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 149
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guaccccccg cauuauuacu cacgguacga guggucuuug      120

aauaaagucu gagugggcgg c                                                141


<210> 150
<211> 119
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 150
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaagucuga gugggcggc       119


<210> 151
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 151
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccuc cauaaaguag gaaacacuac aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 152

<400> 152
000


<210> 153
<211> 23
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 155-5p sequence"

<400> 153
uuaaugcuaa uugugauagg ggu                                               23


<210> 154
<211> 23
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 155-5p binding site sequence"

<400> 154
accccuauca caauuagcau uaa                                               23


<210> 155
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 155
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccauaaag uaggaaacac uacauccccc cagccccucc uccccuuccu      120

gcacccguac ccccuccaua aaguaggaaa cacuacagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 156
<211> 140
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 156
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccag uagugcuuuc uacuuuaugg uggucuuuga      120

auaaagucug agugggcggc                                                  140


<210> 157
<211> 182
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 157
ugauaauaga guagugcuuu cuacuuuaug gcuggagccu cgguggccau gcuucuugcc       60

ccuugggcca guagugcuuu cuacuuuaug uccccccagc cccuccuccc cuuccugcac      120

ccguaccccc aguagugcuu ucuacuuuau gguggucuuu gaauaaaguc ugagugggcg      180

gc                                                                     182


<210> 158
<211> 184
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 158
ugauaauaga guagugcuuu cuacuuuaug gcuggagccu cgguggccau gcuucuugcc       60

ccuugggccu ccauaaagua ggaaacacua caucccccca gccccuccuc cccuuccugc      120

acccguaccc ccaguagugc uuucuacuuu augguggucu uugaauaaag ucugaguggg      180

cggc                                                                   184


<210> 159
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 159
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccac cccuaucaca auuagcauua aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 160
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 160
ugauaauaga ccccuaucac aauuagcauu aagcuggagc cucgguggcc augcuucuug       60

ccccuugggc caccccuauc acaauuagca uuaauccccc cagccccucc uccccuuccu      120

gcacccguac ccccaccccu aucacaauua gcauuaagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 161
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 161
ugauaauaga ccccuaucac aauuagcauu aagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccauaaag uaggaaacac uacauccccc cagccccucc uccccuuccu      120

gcacccguac ccccaccccu aucacaauua gcauuaagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 162
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 162
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 163
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 163
ugauaauagg cuggagccuc gguggcucca uaaaguagga aacacuacac augcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 164
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 164
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cauaaaguag       60

gaaacacuac auccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 165
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 165
gggaaauaag aguccauaaa guaggaaaca cuacaagaaa agaagaguaa gaagaaauau       60

aagagccacc                                                              70


<210> 166
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 166
gggaaauaag agagaaaaga agaguaaucc auaaaguagg aaacacuaca gaagaaauau       60

aagagccacc                                                              70


<210> 167
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 167
gggaaauaag agagaaaaga agaguaagaa gaaauauaau ccauaaagua ggaaacacua       60

cagagccacc                                                              70


<210> 168
<211> 23
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR 155-5p binding site sequence"

<400> 168
accccuauca caauuagcau uaa                                               23


<210> 169
<211> 181
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 169
ugauaauaga guagugcuuu cuacuuuaug gcuggagccu cgguggccau gcuucuugcc       60

ccuugggcca guagugcuuu cuacuuuaug uccccccagc cccucucccc uuccugcacc      120

cguaccccca guagugcuuu cuacuuuaug guggucuuug aauaaagucu gagugggcgg      180

c                                                                      181


<210> 170
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 170
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuuccauaaa guaggaaaca       60

cuacaugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 171
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 171
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagucc       60

auaaaguagg aaacacuaca ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 172
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 172
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu ucuccauaaa guaggaaaca cuacacugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 173
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 173
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaaguucca uaaaguagga      120

aacacuacac ugagugggcg gc                                               142


<210> 174
<211> 164
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 174
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc ccgcauuauu      120

acucacggua cgaguggucu uugaauaaag ucugaguggg cggc                       164


<210> 175
<211> 119
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 175
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccgu ggucuuugaa uaaagucuga gugggcggc       119


<210> 176

<400> 176
000


<210> 177
<211> 141
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 177
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guaccccccg cauuauuacu cacgguacga guggucuuug      120

aauaaagucu gagugggcgg c                                                141


<210> 178
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 178
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc cuccauaaag uaggaaacac uacauccccc cagccccucc uccccuuccu      120

gcacccguac ccccuccaua aaguaggaaa cacuacagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 179
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 179
ugauaauagu ccauaaagua ggaaacacua cagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 180
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 180
ugauaauagg cuggagccuc gguggcucca uaaaguagga aacacuacac uagcuucuug       60

ccccuugggc cuccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 181
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 181
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cauaaaguag       60

gaaacacuac auccccccag ccccuccucc ccuuccugca cccguacccc cguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 182
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 182
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccac cccuaucaca auuagcauua aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 183
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 183
ugauaauaga ccccuaucac aauuagcauu aagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc caccccuauc acaauuagca uuaauccccc cagccccucc uccccuuccu      120

gcacccguac ccccaccccu aucacaauua gcauuaagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 184
<211> 188
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 184
ugauaauaga ccccuaucac aauuagcauu aagcuggagc cucgguggcc uagcuucuug       60

ccccuugggc cuccauaaag uaggaaacac uacauccccc cagccccucc uccccuuccu      120

gcacccguac ccccaccccu aucacaauua gcauuaagug gucuuugaau aaagucugag      180

ugggcggc                                                               188


<210> 185
<211> 47
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      5' UTR sequence"

<400> 185
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210> 186
<211> 142
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 186
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccuc cauaaaguag gaaacacuac aguggucuuu      120

gaauaaaguc ugagugggcg gc                                               142


<210> 187
<211> 740
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 187
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu Gly Gly Gly Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln 
    610                 615                 620                 


Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn 
625                 630                 635                 640 


Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile 
                645                 650                 655     


Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu 
            660                 665                 670         


Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly 
        675                 680                 685             


Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr 
    690                 695                 700                 


Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys 
705                 710                 715                 720 


Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu 
                725                 730                 735     


Pro Val Gln Glu 
            740 


<210> 188
<211> 2220
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 188
augaaguggg ugaccuucau cagccugcug uuccuguuca gcagcgccua cagcagaggc       60

guguucagaa gagacgccca caagagcgag guggcccaca gauucaagga ccugggcgag      120

gagaacuuca aggcccuggu gcugaucgcc uucgcccagu accugcagca gugcccuuuc      180

gaggaccacg ugaagcuggu gaacgaggug accgaguucg ccaagaccug cguggccgac      240

gagagcgccg agaacugcga caagagccug cacacccugu ucggcgacaa gcugugcacc      300

guggccaccc ugagagaaac uuacggcgag auggccgacu gcugcgccaa gcaggagcca      360

gagcggaacg agugcuuccu gcaacacaag gacgacaacc cuaaccugcc uagacugguc      420

cggccugagg uggacgugau gugcacggcc uuccacgaca acgaggagac uuuccugaag      480

aaguaccugu acgagaucgc cagaagacac ccuuacuucu acgccccuga gcuccuguuc      540

uucgcgaaga gauacaaggc cgccuucacc gagugcugcc aggccgccga caaggcagcu      600

ugccugcugc cuaagcugga cgagcugaga gacgagggca aggccuccuc agcuaagcag      660

agacugaagu gcgccagccu gcagaaguuc ggugagagag cauucaaggc uugggccguc      720

gcaagacugu cacagagauu cccuaaggca gaauucgcgg aggugagcaa gcuagugacc      780

gaccugacca aggugcauac agagugcugc cacggcgacc ugcuggagug cgccgacgac      840

agagccgacc uggccaagua caucugcgag aaccaggaca gcaucagcuc caagcugaag      900

gagugcugug agaagccucu gcuggagaag ucacacugca uugccgaggu cgagaacgac      960

gagaugccug ccgaucuucc uagccuugcc gccgauuucg uggagagcaa ggacgugugc     1020

aagaacuacg ccgaggcaaa ggacguguuc cugggcaugu uccuuuacga auacgcucgc     1080

cggcauccag acuacagcgu ggugcugcug cugagauugg ccaagacuua cgagacgacc     1140

cucgagaagu guugcgcagc agcugauccu cacgaguguu acgccaaggu guucgacgag     1200

uucaagccgc uuguggagga gccucagaac cugaucaagc agaauuguga gcuguucgag     1260

cagcugggug aguacaaguu ccagaacgcc cugcuggugc gcuacaccaa gaaggugccu     1320

caagugucua ccccuacccu gguugaaguu ucccgcaacc ugggcaaggu gggcagcaag     1380

ugcugcaagc auccugaagc aaagaggaug ccuugcgccg aggacuaccu gucagugguc     1440

cuuaaccagc ugugcgugcu gcacgagaag accccuguga gcgacagagu gacaaagugu     1500

uguaccgaga gccuggucaa cagaagaccu ugcuucagcg cccuggaagu cgacgagaca     1560

uacgugccua aggaguucaa cgccgaaacc uucaccuucc acgccgacau cugcacacug     1620

agcgagaagg agagacagau caagaagcag accgcccugg ucgaguuggu gaagcacaag     1680

ccuaaggcca ccaaggagca acucaaggcc gugauggacg acuucgcggc cuucguugag     1740

aagugcugua aggcugacga caaggagacg ugcuucgcug aggaggguaa gaagcuuguc     1800

gccgccucuc aggccgcuuu gggacucggc ggcggcagug cgccugccag aagcccuucc     1860

ccaucuaccc agccuuggga gcacgugaac gccauccagg aggccagacg ucugcugaac     1920

cugucacggg auaccgcagc ugagaugaac gaaacuguug aggucaucag cgagauguuc     1980

gaccuacagg aaccuaccug cuugcagacc agacuggagc uguacaagca gggauuaaga     2040

ggcucccuga cgaagcuuaa gggcccucug accaugaugg ccagccacua uaagcagcac     2100

ugcccuccua ccccugaaac gucgugugcu acccagauca ucaccuucga gagcuucaag     2160

gagaaucuga aggacuuccu gcucguuauu ccguucgauu guugggagcc ugugcaggag     2220


<210> 189
<211> 584
<212> PRT
<213> Homo sapiens

<400> 189
Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu 
1               5                   10                  15      


Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln 
            20                  25                  30          


Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe 
        35                  40                  45              


Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser 
    50                  55                  60                  


Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 
65                  70                  75                  80  


Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu 
                85                  90                  95      


Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro 
            100                 105                 110         


Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp 
        115                 120                 125             


Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
    130                 135                 140                 


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr 
145                 150                 155                 160 


Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 
                165                 170                 175     


Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser 
            180                 185                 190         


Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg 
        195                 200                 205             


Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys 
    210                 215                 220                 


Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val 
225                 230                 235                 240 


His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
                245                 250                 255     


Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser 
            260                 265                 270         


Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys 
        275                 280                 285             


Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu 
    290                 295                 300                 


Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu 
305                 310                 315                 320 


Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg 
                325                 330                 335     


His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr 
            340                 345                 350         


Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys 
        355                 360                 365             


Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln 
    370                 375                 380                 


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr 
385                 390                 395                 400 


Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln 
                405                 410                 415     


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val 
            420                 425                 430         


Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala 
        435                 440                 445             


Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu 
    450                 455                 460                 


Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu 
465                 470                 475                 480 


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr 
                485                 490                 495     


Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile 
            500                 505                 510         


Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu 
        515                 520                 525             


Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys 
    530                 535                 540                 


Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala 
545                 550                 555                 560 


Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala 
                565                 570                 575     


Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 



