                         SEQUENCE LISTING

<110>  Icahn School of Medicine At Mount Sinai
       Zhang, Bin
       Yue, Zhenyu
       Wang, Qian
       Wang, Minghui
 
<120>  STATHMIN 2 (STMN2) AS A THERAPEUTIC TARGET FOR PARKINSON'S 
       DISEASE

<130>  3710.045AWO

<150>  62/916,752
<151>  2019-10-17

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1904
<212>  DNA
<213>  Mus musculus

<400>  1
agactcctct ctcgctctct ccgcggctac agctggaccc ttctcctttg ccttcgccac       60

cactccgtgc gtgcacatcc ctacaatggc taaaacagca atggcctaca aggaaaaaat      120

gaaggagctg tctatgctgt cactgatctg ctcctgcttc tacccggagc cgcgcaacat      180

caacatctac acctacgacg acatggaggt gaagcagatc aacaagcggg cctctggcca      240

ggcttttgag ctgatcttga agccaccatc tcccatctca gaagctccac gaactctagc      300

ttctccaaag aagaaagacc tgtctctgga ggagattcag aaaaagctgg aggctgcaga      360

ggagcgaaga aagtctcaag aggctcaggt gctgaagcag ttggcagaga agagggagca      420

cgagcgagag gtgctccaga aggcgctgga ggagaacaac aacttcagca agatggcgga      480

ggagaagctg atcctgaaga tggaacagat taaggaaaac cgtgaggcta atctagctgc      540

tatcattgaa cgtctgcagg aaaaggagag gcatgctgca gaggttcgca ggaacaagga      600

actgcaggtt gaactgtctg gctgaagcaa tggcgggtat ggcaagcccc tcccatagta      660

aatccccctg cctatattat aatggatcat gcgatatcag tatgggaagt gtatgacatg      720

gtttaaaaag aactcattat gaaaaacaaa acaaaaaaca gaatcaaaaa taaaataaaa      780

atcaatgcgg tctctttgca gaatgttttg cttgatgttt aaaaaagtac cttggatctt      840

attttgtaaa tatttacatt tttgttaaaa aatacaagta ttgcattatg caagttattt      900

catgatctta catgtcctgt aacaggcttt tgacgttgtg tctttccact cagatggatt      960

tgctaggtct gttcttttgg aagccccact cagtccctgc ccttttcatt ccaaccgaaa     1020

aatgaggtca gtagacagtc tatggtgcta gaaacccacc attgcctaat gacctagatg     1080

actccgtaat ctctgagcgt gaccaagacc acacctagat cgtgggtact gtgtgtccat     1140

gtgaacctcc acatttgctc gtaatctgct tcctgcctag aagcggcaaa gccaggctaa     1200

gggaatctac cagtcatagc acttatgtct gctcctcatg gattacgcgc tacacatgtg     1260

tttgggtttt agaaacaggt gcatgtgaag acaaatctga gctcagtcag ggtagaagcg     1320

aaaggctgaa ccttccaacg tgctgatcac aaacgcaaag ccagagggtt caagcagcca     1380

tgggattgtt cttcatgaag tgggcttatt tctctcattt tagttattat gatgggatga     1440

attaattgac atgtcgggtg gcttatctgt gggtgccatg ggtgatgatg ttcattttaa     1500

gcttttgcct gtagtacaag cacataatgc tactgaacgt ttttccactt ggagactgtg     1560

agctggttgc tgcattaaaa acacaaacaa aatcacaagc actgtggact tttactcaag     1620

ctggtctttc ttccccagtg tagggcaatc ctgcctataa acaagaccaa accactccat     1680

ctgtgatgct gacgcagtga aggggccagg cagggcattt gtgccaagta taagaatcag     1740

cagacaccca gcatacgtac ctattgcagt tttgaagttg tttctcccta actcccaact     1800

cccaactccc aaactgcctg catatttact cttcgtcagt gctatcttct tgtatgtcat     1860

tgtgagcaag ctgtgatgaa taaagaattg gagttctgtg aact                      1904


<210>  2
<211>  179
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Lys Thr Ala Met Ala Tyr Lys Glu Lys Met Lys Glu Leu Ser 
1               5                   10                  15      


Met Leu Ser Leu Ile Cys Ser Cys Phe Tyr Pro Glu Pro Arg Asn Ile 
            20                  25                  30          


Asn Ile Tyr Thr Tyr Asp Asp Met Glu Val Lys Gln Ile Asn Lys Arg 
        35                  40                  45              


Ala Ser Gly Gln Ala Phe Glu Leu Ile Leu Lys Pro Pro Ser Pro Ile 
    50                  55                  60                  


Ser Glu Ala Pro Arg Thr Leu Ala Ser Pro Lys Lys Lys Asp Leu Ser 
65                  70                  75                  80  


Leu Glu Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys 
                85                  90                  95      


Ser Gln Glu Ala Gln Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His 
            100                 105                 110         


Glu Arg Glu Val Leu Gln Lys Ala Leu Glu Glu Asn Asn Asn Phe Ser 
        115                 120                 125             


Lys Met Ala Glu Glu Lys Leu Ile Leu Lys Met Glu Gln Ile Lys Glu 
    130                 135                 140                 


Asn Arg Glu Ala Asn Leu Ala Ala Ile Ile Glu Arg Leu Gln Glu Lys 
145                 150                 155                 160 


Glu Arg His Ala Ala Glu Val Arg Arg Asn Lys Glu Leu Gln Val Glu 
                165                 170                 175     


Leu Ser Gly 
            


<210>  3
<211>  1985
<212>  DNA
<213>  Homo sapiens

<400>  3
agtcttctct ctcgctctct ccgctgctgt agccggaccc tttgccttcg ccactgctca       60

gcgtctgcac atccctacaa tggctaaaac agcaatggcc tacaaggaaa aaatgaagga      120

gctgtccatg ctgtcactga tctgctcttg cttttacccg gaacctcgca acatcaacat      180

ctatacttac gatgatatgg aagtgaagca aatcaacaaa cgtgcctctg gccaggcttt      240

tgagctgatc ttgaagccac catctcctat ctcagaagcc ccacgaactt tagcttctcc      300

aaagaagaaa gacctgtccc tggaggagat ccagaagaaa ctggaggctg cagaggaaag      360

aagaaagtct caggaggccc aggtgctgaa acaattggca gagaagaggg aacacgagcg      420

agaagtcctt cagaaggctt tggaggagaa caacaacttc agcaagatgg cggaggaaaa      480

gctgatcctg aaaatggaac aaattaagga aaaccgtgag gctaatctag ctgctattat      540

tgaacgtctg caggaaaagc tggtcaagtt tatttcttct gaactaaaag aatctataga      600

gtctcaattt ctggagcttc agagggaagg agagaagcaa tgagaggcat gctgcggagg      660

tgcgcaggaa caaggaactc caggttgaac tgtctggctg aagcaaggga gggtctggca      720

cgccccacca atagtaaatc cccctgccta tattataatg gatcatgcga tatcaggatg      780

gggaatgtat gacatggttt aaaaagaact cattataaaa aaaaaaaaac aaaaaaaatc      840

aaaaattaaa aaaaatcaat gcggtctctt tgcagaatgt tttgcttgat gtttaaaaaa      900

taccttggat cttattttgt aaatacttac atttttgtta aaaaatacaa gtattgcatt      960

atgcaagtta tttcataatc ttacatgtcc tgtaacaggc ttttgatgtt gtgtctttcc     1020

actcaaatga atttgctagg tctgttcttt ttgaagctcc ccatgtctaa ctccattcca     1080

aaagaaaaat gaggtcagta gacagtctat ggtgctagaa acccaccatt gcctaatgac     1140

ctagaaggct ttgttgtctc tgagcttgac taagaccata cctagatcac aggtattatg     1200

actccacatg aaccttcaca tttgttcgct cataatctac ttactgccta aaaactacaa     1260

aaccaggcta agaaatacca ccagtcatag catttacttc tgcttctcct ggattatgtg     1320

ctacaaatgt gctttggctt tagaaaggga tggatgagaa gacagacctg agaccaatct     1380

gggtagaagc aaaaagttga accttttaaa gtgctgaaca caaatccaaa ttcgaatggt     1440

tcaagcagcc gtgaaatcgc tcttcataaa gtgggcttaa ttctctagtt taagttcttt     1500

tgatggaatg aattaattaa tgtgtcaggt ggcttatttg tggatgccat gattgatgat     1560

gttcatttta agctcttacc tatagtacaa gtacatgatg ctactgaata tttttccact     1620

tggaaactgt gagctggttg ttgcattaaa acacacatac aaacaaaatc aaaaacactg     1680

cggactttca ctcaagctgg tctttcttcc ccagtgtaag gcaatcctgc ctactaacaa     1740

caccaacaac aaaacactcc atctgtgaag ctgacgcagt taagggggct aggcagggca     1800

tttgtgccaa ctaagaatca ccagataccc accataagta cctatcgcag ttttgaagtc     1860

gtttctcccc aactcccaac tcctgaaggt tgctgcctgc atatttactc ttcattagtg     1920

ctattttcct gtatgtcatt gtgagcaagc tgtgattaat aaagaattgg agttctgtga     1980

actaa                                                                 1985


<210>  4
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Lys Thr Ala Met Ala Tyr Lys Glu Lys Met Lys Glu Leu Ser 
1               5                   10                  15      


Met Leu Ser Leu Ile Cys Ser Cys Phe Tyr Pro Glu Pro Arg Asn Ile 
            20                  25                  30          


Asn Ile Tyr Thr Tyr Asp Asp Met Glu Val Lys Gln Ile Asn Lys Arg 
        35                  40                  45              


Ala Ser Gly Gln Ala Phe Glu Leu Ile Leu Lys Pro Pro Ser Pro Ile 
    50                  55                  60                  


Ser Glu Ala Pro Arg Thr Leu Ala Ser Pro Lys Lys Lys Asp Leu Ser 
65                  70                  75                  80  


Leu Glu Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys 
                85                  90                  95      


Ser Gln Glu Ala Gln Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His 
            100                 105                 110         


Glu Arg Glu Val Leu Gln Lys Ala Leu Glu Glu Asn Asn Asn Phe Ser 
        115                 120                 125             


Lys Met Ala Glu Glu Lys Leu Ile Leu Lys Met Glu Gln Ile Lys Glu 
    130                 135                 140                 


Asn Arg Glu Ala Asn Leu Ala Ala Ile Ile Glu Arg Leu Gln Glu Lys 
145                 150                 155                 160 


Leu Val Lys Phe Ile Ser Ser Glu Leu Lys Glu Ser Ile Glu Ser Gln 
                165                 170                 175     


Phe Leu Glu Leu Gln Arg Glu Gly Glu Lys Gln 
            180                 185         


<210>  5
<211>  2232
<212>  DNA
<213>  Homo sapiens

<400>  5
agctcctagg aagcttcagg gcttaaagct ccactctact tggactgtac tatcaggccc       60

ccaaaatggg gggagccgac agggaaggac tgatttccat ttcaaactgc attctggtac      120

tttgtactcc agcaccattg gccgatcaat atttaatgct tggagattct gactctgcgg      180

gagtcatgtc aggggacctt gggagccaat ctgcttgagc ttctgagtga taattattca      240

tgggctcctg cctcttgctc tttctctagc acggtcccac tctgcagact cagtgcctta      300

ttcagtcttc tctctcgctc tctccgctgc tgtagccgga ccctttgcct tcgccactgc      360

tcagcgtctg cacatcccta caatggctaa aacagcaatg gcctacaagg aaaaaatgaa      420

ggagctgtcc atgctgtcac tgatctgctc ttgcttttac ccggaacctc gcaacatcaa      480

catctatact tacgatgata tggaagtgaa gcaaatcaac aaacgtgcct ctggccaggc      540

ttttgagctg atcttgaagc caccatctcc tatctcagaa gccccacgaa ctttagcttc      600

tccaaagaag aaagacctgt ccctggagga gatccagaag aaactggagg ctgcagagga      660

aagaagaaag tctcaggagg cccaggtgct gaaacaattg gcagagaaga gggaacacga      720

gcgagaagtc cttcagaagg ctttggagga gaacaacaac ttcagcaaga tggcggagga      780

aaagctgatc ctgaaaatgg aacaaattaa ggaaaaccgt gaggctaatc tagctgctat      840

tattgaacgt ctgcaggaaa aggagaggca tgctgcggag gtgcgcagga acaaggaact      900

ccaggttgaa ctgtctggct gaagcaaggg agggtctggc acgccccacc aatagtaaat      960

ccccctgcct atattataat ggatcatgcg atatcaggat ggggaatgta tgacatggtt     1020

taaaaagaac tcattataaa aaaaaaaaaa caaaaaaaat caaaaattaa aaaaaatcaa     1080

tgcggtctct ttgcagaatg ttttgcttga tgtttaaaaa ataccttgga tcttattttg     1140

taaatactta catttttgtt aaaaaataca agtattgcat tatgcaagtt atttcataat     1200

cttacatgtc ctgtaacagg cttttgatgt tgtgtctttc cactcaaatg aatttgctag     1260

gtctgttctt tttgaagctc cccatgtcta actccattcc aaaagaaaaa tgaggtcagt     1320

agacagtcta tggtgctaga aacccaccat tgcctaatga cctagaaggc tttgttgtct     1380

ctgagcttga ctaagaccat acctagatca caggtattat gactccacat gaaccttcac     1440

atttgttcgc tcataatcta cttactgcct aaaaactaca aaaccaggct aagaaatacc     1500

accagtcata gcatttactt ctgcttctcc tggattatgt gctacaaatg tgctttggct     1560

ttagaaaggg atggatgaga agacagacct gagaccaatc tgggtagaag caaaaagttg     1620

aaccttttaa agtgctgaac acaaatccaa attcgaatgg ttcaagcagc cgtgaaatcg     1680

ctcttcataa agtgggctta attctctagt ttaagttctt ttgatggaat gaattaatta     1740

atgtgtcagg tggcttattt gtggatgcca tgattgatga tgttcatttt aagctcttac     1800

ctatagtaca agtacatgat gctactgaat atttttccac ttggaaactg tgagctggtt     1860

gttgcattaa aacacacata caaacaaaat caaaaacact gcggactttc actcaagctg     1920

gtctttcttc cccagtgtaa ggcaatcctg cctactaaca acaccaacaa caaaacactc     1980

catctgtgaa gctgacgcag ttaagggggc taggcagggc atttgtgcca actaagaatc     2040

accagatacc caccataagt acctatcgca gttttgaagt cgtttctccc caactcccaa     2100

ctcctgaagg ttgctgcctg catatttact cttcattagt gctattttcc tgtatgtcat     2160

tgtgagcaag ctgtgattaa taaagaattg gagttctgtg aactaataaa ggtttggtct     2220

gttaaaaaaa aa                                                         2232


<210>  6
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Lys Thr Ala Met Ala Tyr Lys Glu Lys Met Lys Glu Leu Ser 
1               5                   10                  15      


Met Leu Ser Leu Ile Cys Ser Cys Phe Tyr Pro Glu Pro Arg Asn Ile 
            20                  25                  30          


Asn Ile Tyr Thr Tyr Asp Asp Met Glu Val Lys Gln Ile Asn Lys Arg 
        35                  40                  45              


Ala Ser Gly Gln Ala Phe Glu Leu Ile Leu Lys Pro Pro Ser Pro Ile 
    50                  55                  60                  


Ser Glu Ala Pro Arg Thr Leu Ala Ser Pro Lys Lys Lys Asp Leu Ser 
65                  70                  75                  80  


Leu Glu Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys 
                85                  90                  95      


Ser Gln Glu Ala Gln Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His 
            100                 105                 110         


Glu Arg Glu Val Leu Gln Lys Ala Leu Glu Glu Asn Asn Asn Phe Ser 
        115                 120                 125             


Lys Met Ala Glu Glu Lys Leu Ile Leu Lys Met Glu Gln Ile Lys Glu 
    130                 135                 140                 


Asn Arg Glu Ala Asn Leu Ala Ala Ile Ile Glu Arg Leu Gln Glu Lys 
145                 150                 155                 160 


Glu Arg His Ala Ala Glu Val Arg Arg Asn Lys Glu Leu Gln Val Glu 
                165                 170                 175     


Leu Ser Gly 
            


<210>  7
<211>  540
<212>  DNA
<213>  Mus musculus

<400>  7
atggctaaaa cagcaatggc ctacaaggaa aaaatgaagg agctgtctat gctgtcactg       60

atctgctcct gcttctaccc ggagccgcgc aacatcaaca tctacaccta cgacgacatg      120

gaggtgaagc agatcaacaa gcgggcctct ggccaggctt ttgagctgat cttgaagcca      180

ccatctccca tctcagaagc tccacgaact ctagcttctc caaagaagaa agacctgtct      240

ctggaggaga ttcagaaaaa gctggaggct gcagaggagc gaagaaagtc tcaagaggct      300

caggtgctga agcagttggc agagaagagg gagcacgagc gagaggtgct ccagaaggcg      360

ctggaggaga acaacaactt cagcaagatg gcggaggaga agctgatcct gaagatggaa      420

cagattaagg aaaaccgtga ggctaatcta gctgctatca ttgaacgtct gcaggaaaag      480

gagaggcatg ctgcagaggt tcgcaggaac aaggaactgc aggttgaact gtctggctga      540


<210>  8
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  8
atggctaaaa cagcaatggc ctacaaggaa aaaatgaagg agctgtccat gctgtcactg       60

atctgctctt gcttttaccc ggaacctcgc aacatcaaca tctatactta cgatgatatg      120

gaagtgaagc aaatcaacaa acgtgcctct ggccaggctt ttgagctgat cttgaagcca      180

ccatctccta tctcagaagc cccacgaact ttagcttctc caaagaagaa agacctgtcc      240

ctggaggaga tccagaagaa actggaggct gcagaggaaa gaagaaagtc tcaggaggcc      300

caggtgctga aacaattggc agagaagagg gaacacgagc gagaagtcct tcagaaggct      360

ttggaggaga acaacaactt cagcaagatg gcggaggaaa agctgatcct gaaaatggaa      420

caaattaagg aaaaccgtga ggctaatcta gctgctatta ttgaacgtct gcaggaaaag      480

gagaggcatg ctgcggaggt gcgcaggaac aaggaactcc aggttgaact gtctggctga      540


