                         б

<110>  ԴƼ޹˾
 
<120>  һֿPD-L1Ŀ弰ҩ;

<130>  LC19110063

<160>  86    

<170>  PatentIn version 3.3

<210>  1
<211>  334
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  CH1-CH3 㶨

<400>  1

Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
1               5                   10                  15      


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
            20                  25                  30          


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
        35                  40                  45              


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    50                  55                  60                  


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
65                  70                  75                  80  


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
                85                  90                  95      


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
            100                 105                 110         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    130                 135                 140                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
145                 150                 155                 160 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                165                 170                 175     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        195                 200                 205             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    210                 215                 220                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
225                 230                 235                 240 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                245                 250                 255     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            260                 265                 270         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        275                 280                 285             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    290                 295                 300                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
305                 310                 315                 320 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330                 


<210>  2
<211>  111
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  CL1 㶨

<400>  2

Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
1               5                   10                  15      


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
            20                  25                  30          


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
        35                  40                  45              


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
    50                  55                  60                  


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
65                  70                  75                  80  


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
                85                  90                  95      


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105                 110     


<210>  3
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  4
<211>  98
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  1-46.01 ģ

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  5
<211>  95
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  1-5.01 ģ

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser 
                85                  90                  95  


<210>  6
<211>  448
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  Atezolizumab 

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  7
<211>  214
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  Atezolizumab 

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  8
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  9
<211>  121
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  14A7-VH

<400>  9

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Thr Glu Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Trp Ile Ala Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile His Pro Gly Gly Gly Phe Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Val Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Lys Thr Arg Asp Tyr Asp Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  10
<211>  112
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  14A7-VL

<400>  10

Asp Ile Val Met Thr Gln Ala Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Val Lys Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  11
<211>  114
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  15G10-VH

<400>  11

Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Thr Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Val His Trp Val Lys Gln Asn Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Asn Pro Asn Asn Asp Gly Thr Ile Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  12
<211>  111
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  15G10-VL

<400>  12

Gln Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Ser Ala Ser Glu Ser Val Asp Phe Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Val Tyr Thr Ala Ser Asn Val Asp Ser Glu Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys His Gln Thr Arg 
                85                  90                  95      


Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  13
<211>  118
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  13C9-VH

<400>  13

Gln Val Gln Leu Lys Gln Ser Gly Ala Gly Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Glu Tyr 
            20                  25                  30          


Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe Tyr Pro Gly Ser Asp Asn Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Glu Thr Gly Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  14
<211>  108
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  13C9-VL

<400>  14

Asp Ile Val Ile Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Lys Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Arg Ala 
            100                 105             


<210>  15
<211>  118
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  18B4-VH

<400>  15

Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Val Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Glu Ser Ser Ser Thr Ala Ser 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ile Pro Phe Tyr Gly Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  16
<211>  108
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  18B4-VL

<400>  16

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Gly Ala Ser Ser Ser Val Ser Phe Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Thr Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105             


<210>  17
<211>  118
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  28B1-VH

<400>  17

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Met Leu Ser Cys Thr Ala Ser Ala Phe Asn Ile Asp Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Asp Tyr Asp Pro Glu Cys 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Met Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Leu Pro Gly Leu Val Tyr Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  18
<211>  109
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  28B1-VL

<400>  18

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asn Thr Leu Glu Glu 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Ile Arg Ala 
            100                 105                 


<210>  19
<211>  118
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  22B10-VH

<400>  19

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Glu Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Glu Asp Thr 
            20                  25                  30          


Tyr Leu His Trp Val Asn Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Tyr Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Arg Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Leu Pro Gly Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  20
<211>  109
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  22B10-VL

<400>  20

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Ala Ile Ser Asn Leu Asp Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  21
<211>  118
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  4G7-VH

<400>  21

Gln Val Gln Leu Lys Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Ile Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Glu Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ser Ile Ile Arg Asp Thr Phe Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Gly Glu Trp Leu Leu His Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  22
<211>  113
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  4G7-VL

<400>  22

Asp Ile Val Met Thr Gln Ala Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Val Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  23
<211>  113
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  8A2-VH

<400>  23

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Lys Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  24
<211>  105
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  8A2-VL

<400>  24

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Glu Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His His Arg Ser Pro Tyr Pro Thr Phe 
                85                  90                  95      


Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105 


<210>  25
<211>  113
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  7E5-VH

<400>  25

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Lys Ile Trp Gly Asp Gly Ser Thr Asp Tyr Thr Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Val Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  26
<211>  105
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  7E5-VL

<400>  26

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Glu Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Pro Tyr Pro Thr Phe 
                85                  90                  95      


Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105 


<210>  27
<211>  113
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  2E5-VH

<400>  27

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Lys Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  28
<211>  112
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  2E5-VL

<400>  28

Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Glu Gln Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ser Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  113
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  10A3-VH

<400>  29

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Lys Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Val Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  30
<211>  107
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  10A3-VL

<400>  30

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Asn Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Glu Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His His Arg Ser Pro Tyr Pro Thr Phe 
                85                  90                  95      


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala 
            100                 105         


<210>  31
<211>  121
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  6G5-VH

<400>  31

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Thr Glu Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Trp Ile Ala Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile His Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Lys Thr Arg Asp Tyr Asp Ser Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  32
<211>  108
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  6G5-VL

<400>  32

Asp Ile Val Ile Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Lys Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Arg Ala 
            100                 105             


<210>  33
<211>  121
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  14A7-VH-hz

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Glu Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile His Pro Gly Gly Gly Phe Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Val Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Lys Thr Arg Asp Tyr Asp Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  34
<211>  112
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  14A7-VL-hz

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  35
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR1

<400>  35

Glu Tyr Thr Phe Thr Asn Asn Trp Ile Ala 
1               5                   10  


<210>  36
<211>  17
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR2

<400>  36

Asp Ile His Pro Gly Gly Gly Phe Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Val 
    


<210>  37
<211>  12
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR3

<400>  37

Ser Lys Thr Arg Asp Tyr Asp Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  38
<211>  17
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR1

<400>  38

Lys Ser Ser Gln Ser Leu Leu Tyr Thr Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  39
<211>  7
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR2

<400>  39

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  40
<211>  8
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR3

<400>  40

Gln Gln Tyr Tyr Thr Tyr Arg Thr 
1               5               


<210>  41
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR1

<400>  41

Gly Tyr Thr Phe Thr Asn Tyr Val Val His 
1               5                   10  


<210>  42
<211>  17
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR2

<400>  42

Tyr Val Asn Pro Asn Asn Asp Gly Thr Ile Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  43
<211>  5
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR3

<400>  43

Ser Pro Phe Ala His 
1               5   


<210>  44
<211>  15
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR1

<400>  44

Ser Ala Ser Glu Ser Val Asp Phe Tyr Gly Thr Ser Leu Met Gln 
1               5                   10                  15  


<210>  45
<211>  7
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR2

<400>  45

Thr Ala Ser Asn Val Asp Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR3

<400>  46

His Gln Thr Arg Lys Val Pro Tyr Thr 
1               5                   


<210>  47
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR1

<400>  47

Gly Tyr Ile Phe Thr Glu Tyr Ile Ile His 
1               5                   10  


<210>  48
<211>  17
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR2

<400>  48

Trp Phe Tyr Pro Gly Ser Asp Asn Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  49
<211>  9
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR3

<400>  49

His Glu Thr Gly Tyr Phe Phe Asp Tyr 
1               5                   


<210>  50
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR1

<400>  50

Ser Ala Ser Ser Ser Val Ser Lys Met Asn 
1               5                   10  


<210>  51
<211>  7
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR2

<400>  51

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  52
<211>  9
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR3

<400>  52

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


<210>  53
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR1

<400>  53

Gly Tyr Ser Phe Thr Gly Tyr Asn Met Asn 
1               5                   10  


<210>  54
<211>  17
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR2

<400>  54

Asn Ile Asp Pro Tyr Tyr Gly Val Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  9
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR3

<400>  55

Gly Ile Pro Phe Tyr Gly Leu Asp Tyr 
1               5                   


<210>  56
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR1

<400>  56

Gly Ala Ser Ser Ser Val Ser Phe Met His 
1               5                   10  


<210>  57
<211>  9
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR3

<400>  57

Gln Gln Trp Asn Thr Asn Pro Phe Thr 
1               5                   


<210>  58
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR1

<400>  58

Ala Phe Asn Ile Asp Asp Thr Tyr Ile His 
1               5                   10  


<210>  59
<211>  17
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR2

<400>  59

Arg Ile Asp Pro Ala Asn Gly Asn Thr Asp Tyr Asp Pro Glu Cys Gln 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  9
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR3

<400>  60

Gly Leu Arg Leu Pro Gly Leu Val Tyr 
1               5                   


<210>  61
<211>  11
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR1

<400>  61

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  62
<211>  7
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR2

<400>  62

Tyr Thr Ser Ile Leu Tyr Ser 
1               5           


<210>  63
<211>  9
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR3

<400>  63

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  64
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR1

<400>  64

Gly Phe Asn Ile Glu Asp Thr Tyr Leu His 
1               5                   10  


<210>  65
<211>  17
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR2

<400>  65

Arg Ile Asp Pro Ala Asn Gly Asn Thr Tyr Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  66
<211>  9
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR3

<400>  66

Gly Leu Arg Leu Pro Gly Phe Pro Tyr 
1               5                   


<210>  67
<211>  11
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR1

<400>  67

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ser 
1               5                   10      


<210>  68
<211>  7
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR2

<400>  68

Tyr Thr Ser Ile Leu His Ser 
1               5           


<210>  69
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR1

<400>  69

Gly Asp Ser Ile Ile Ser Gly Tyr Trp Asn 
1               5                   10  


<210>  70
<211>  16
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR2

<400>  70

Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  71
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR3

<400>  71

Arg Gly Glu Trp Leu Leu His Phe Asp Val 
1               5                   10  


<210>  72
<211>  17
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR1

<400>  72

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Ser Leu 
1               5                   10                  15      


Ala 
    


<210>  73
<211>  9
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR3

<400>  73

Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  74
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR1

<400>  74

Gly Phe Ser Leu Thr Gly Tyr Gly Val Asn 
1               5                   10  


<210>  75
<211>  16
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR2

<400>  75

Lys Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  76
<211>  5
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR3

<400>  76

Asp Val Met Asp Tyr 
1               5   


<210>  77
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR1

<400>  77

Ser Ala Ser Ser Ser Ile Ser Tyr Met His 
1               5                   10  


<210>  78
<211>  8
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR3

<400>  78

His His Arg Ser Pro Tyr Pro Thr 
1               5               


<210>  79
<211>  16
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR2

<400>  79

Lys Ile Trp Gly Asp Gly Ser Thr Asp Tyr Thr Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  80
<211>  8
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR3

<400>  80

His Gln Arg Ser Pro Tyr Pro Thr 
1               5               


<210>  81
<211>  16
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR1

<400>  81

Arg Ser Ser Gln Ser Ile Glu Gln Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  82
<211>  7
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR2

<400>  82

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  83
<211>  9
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR3

<400>  83

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  84
<211>  10
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  L-CDR1

<400>  84

Ser Ala Ser Ser Ser Ile Asn Tyr Met His 
1               5                   10  


<210>  85
<211>  17
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR2

<400>  85

Asp Ile His Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  12
<212>  PRT
<213>  ˹(Artificial)

<220>
<221>  PEPTIDE
<222>  ()..()
<223>  H-CDR3

<400>  86

Ser Lys Thr Arg Asp Tyr Asp Ser Trp Phe Ala Tyr 
1               5                   10          


