
                                SEQUENCE LISTING

<110> Jaan Biotherapeutics LLC
      Brar, Bhawanjit Kaur

<120> COMPOSITIONS AND METHODS FOR MITIGATION OF ISCHEMIC REPERFUSION INJURY

<130> 68BX-306236-WO

<150> 62/981531          
<151> 2020-02-26  

<150> 62/961418           
<151> 2020-01-15  

<150> 62/937429           
<151> 2019-11-19  

<150> 62/923612           
<151> 2019-10-21  

<160> 101

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> hsa-let-7a-5p MIMAT0000062 Sense

<400> 1
ugagguagua gguuguauag uu                                          22

<210> 2
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> hsa-let-7a-5p MIMAT0000062 Anti-sense

<400> 2
acuccaucau ccaacauauc aa                                          22

<210> 3
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> hsa-let-7c-5p MIMAT0000064 Sense

<400> 3
ugagguagua gguuguaugg uu                                          22

<210> 4
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> hsa-let-7c-5p MIMAT0000064 Anti-sense

<400> 4
acuccaucau ccaacauacc aa                                          22

<210> 5
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> hsa-miR-99a-5p MIMAT0000097 Sense

<400> 5
aacccguaga uccgaucuug ug                                          22

<210> 6
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> hsa-miR-99a-5p MIMAT0000097 Anti-sense

<400> 6
uugggcaucu aggcuagaac ac                                          22

<210> 7
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> hsa-miR-100-5p MIMAT0000098 Sense

<400> 7
aacccguaga uccgaacuug ug                                          22

<210> 8
<211> 22
<212> RNA
<213> Artificial Sequence

<220> 
<223> hsa-miR-100-5p MIMAT0000098 Anti-sense

<400> 8
uugggcaucu aggcuugaac ac                                          22

<210> 9
<211> 22
<212> RNA
<213> Danio rerio

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> dre-let-7a-5p

<400> 9
ugagguagua gguuguauag uu                                          22

<210> 10
<211> 22
<212> RNA
<213> Mus musculus

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> mmu-let-7a-5p

<400> 10
ugagguagua gguuguauag uu                                          22

<210> 11
<211> 22
<212> RNA
<213> Rattus norvegicus

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> rno-let-7a-5p

<400> 11
ugagguagua gguuguauag uu                                          22

<210> 12
<211> 22
<212> RNA
<213> Sus scrofa

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> ssc-let-7a-5p

<400> 12
ugagguagua gguuguauag uu                                          22

<210> 13
<211> 22
<212> RNA
<213> Pan troglodytes

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> ptr-let-7a-5p

<400> 13
ugagguagua gguuguauag uu                                          22

<210> 14
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> hsa-let-7a-5p

<400> 14
ugagguagua gguuguauag uu                                          22

<210> 15
<211> 22
<212> RNA
<213> Canis familiaris

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> cfa-let-7a-5p

<400> 15
ugagguagua gguuguauag uu                                          22

<210> 16
<211> 22
<212> RNA
<213> Danio rerio

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> dre-let-7c-5p

<400> 16
ugagguagua gguuguaugg uu                                          22

<210> 17
<211> 22
<212> RNA
<213> Mus musculus

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> mmu-let-7c-5p

<400> 17
ugagguagua gguuguaugg uu                                          22

<210> 18
<211> 22
<212> RNA
<213> Rattus norvegicus

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> rno-let-7c-5p

<400> 18
ugagguagua gguuguaugg uu                                          22

<210> 19
<211> 22
<212> RNA
<213> Sus scrofa

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> ssc-let-7c-5p

<400> 19
ugagguagua gguuguaugg uu                                          22

<210> 20
<211> 22
<212> RNA
<213> Pan troglodytes

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> ptr-let-7c-5p

<400> 20
ugagguagua gguuguaugg uu                                          22

<210> 21
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> hsa-let-7c-5p

<400> 21
ugagguagua gguuguaugg uu                                          22

<210> 22
<211> 22
<212> RNA
<213> Canis familiaris

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> cfa-let-7c-5p

<400> 22
ugagguagua gguuguaugg uu                                          22

<210> 23
<211> 22
<212> RNA
<213> Danio rerio

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> dre-miR-99a-5p

<400> 23
aacccguaga uccgaucuug ug                                          22

<210> 24
<211> 22
<212> RNA
<213> Mus musculus

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> mmu-miR-99a-5p

<400> 24
aacccguaga uccgaucuug ug                                          22

<210> 25
<211> 22
<212> RNA
<213> Rattus norvegicus

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> rno-miR-99a-5p

<400> 25
aacccguaga uccgaucuug ug                                          22

<210> 26
<211> 21
<212> RNA
<213> Canis familiaris

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> cfa-miR-99a

<400> 26
aacccguaga uccgaucuug u                                           21

<210> 27
<211> 22
<212> RNA
<213> Sus scrofa

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> ssc-miR-99a

<400> 27
aacccguaga uccgaucuug ug                                          22

<210> 28
<211> 22
<212> RNA
<213> Pan troglodytes

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> ptr-miR-99a

<400> 28
aacccguaga uccgaucuug ug                                          22

<210> 29
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> hsa-miR-99a-5p

<400> 29
aacccguaga uccgaucuug ug                                          22

<210> 30
<211> 22
<212> RNA
<213> Danio rerio

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> dre-miR-100-5p

<400> 30
aacccguaga uccgaacuug ug                                          22

<210> 31
<211> 22
<212> RNA
<213> Mus musculus

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> mmu-miR-100-5p

<400> 31
aacccguaga uccgaacuug ug                                          22

<210> 32
<211> 22
<212> RNA
<213> Rattus norvegicus

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> rno-miR-100-5p

<400> 32
aacccguaga uccgaacuug ug                                          22

<210> 33
<211> 22
<212> RNA
<213> Sus scrofa

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> ssc-miR-100

<400> 33
aacccguaga uccgaacuug ug                                          22

<210> 34
<211> 22
<212> RNA
<213> Pan troglodytes

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> ptr-miR-100

<400> 34
aacccguaga uccgaacuug ug                                          22

<210> 35
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> (0)...(0)
<223> hsa-miR-100-5p

<400> 35
aacccguaga uccgaacuug ug                                          22

<210> 36
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0100

<400> 36
ccatacaacc tactacctc                                              19

<210> 37
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0101

<400> 37
ctatacaacc tactacctc                                              19

<210> 38
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0102

<400> 38
catacaacct actacctc                                               18

<210> 39
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0103

<400> 39
tatacaacct actacctc                                               18

<210> 40
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0104

<400> 40
atacaaccta ctacctc                                                17

<210> 41
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0105

<400> 41
atacaaccta ctacctc                                                17

<210> 42
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0106

<400> 42
tacaacctac tacctc                                                 16

<210> 43
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0107

<400> 43
tacaacctac tacctc                                                 16

<210> 44
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0108

<400> 44
acaacctact acctc                                                  15

<210> 45
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0109

<400> 45
acaacctact acctc                                                  15

<210> 46
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0110

<400> 46
caagttcgga tctacgggt                                              19

<210> 47
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0111

<400> 47
caagatcgga tctacgggt                                              19

<210> 48
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0112

<400> 48
aagatcggat ctacgggt                                               18

<210> 49
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0113

<400> 49
aagttcggat ctacgggt                                               18

<210> 50
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0114

<400> 50
agatcggatc tacgggt                                                17

<210> 51
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0115

<400> 51
agttcggatc tacgggt                                                17

<210> 52
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0116

<400> 52
gatcggatct acgggt                                                 16

<210> 53
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0117

<400> 53
gttcggatct acgggt                                                 16

<210> 54
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0118

<400> 54
atcggatcta cgggt                                                  15

<210> 55
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> JRX0119

<400> 55
ttcggatcta cgggt                                                  15

<210> 56
<211> 7
<212> DNA
<213> Artificial Sequence

<220> 
<223> Loop sequence

<400> 56
tgtgctt                                                           7

<210> 57
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for mouse U6 promoter

<400> 57
tcgcacagac ttgtgggaga a                                           21

<210> 58
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer mouse U6 promoter

<400> 58
cgcacattaa gcctctatag ttactagg                                    28

<210> 59
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a-5p sequence in vector JBT-miR1

<400> 59
gtgaggtagt aggttgtata gtttcaagag aactatacaa cctactacct cattttt    57

<210> 60
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-99a-5p sequence in vector JBT-miR1

<400> 60
gaacccgtag atccgatctt gtgtcaagag cacaagatcg gatctacggg ttttttt    57

<210> 61
<211> 120
<212> DNA
<213> Artificial Sequence

<220> 
<223> (H1-)let-7a-5p & (U6)-miR-99a-5p in vector JBT-miR1

<400> 61
gtgaggtagt aggttgtata gtttcaagag aactatacaa cctactacct catttttgag 60
ctcaaaaaaa cccgtagatc cgatcttgtg ctcttgacac aagatcggat ctacgggttc 120


<210> 62
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7c-5p sequence in vector JBT-miR1

<400> 62
gtgaggtagt aggttgtatg gtttcaagag aaccatacaa cctactacct cattttt    57

<210> 63
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-100-5p sequence in vector JBT-miR1

<400> 63
gaacccgtag atccgaactt gtgtcaagag cacaagttcg gatctacggg ttttttt    57

<210> 64
<211> 120
<212> DNA
<213> Artificial Sequence

<220> 
<223> (H1-)let-7C-5p & (U6)-miR-100-5p in vector JBT-miR1

<400> 64
gtgaggtagt aggttgtatg gtttcaagag aaccatacaa cctactacct catttttgag 60
ctcaaaaaaa cccgtagatc cgaacttgtg ctcttgacac aagttcggat ctacgggttc 120


<210> 65
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7c inhibitor sequence

<400> 65
ccatacaacc tactacctc                                              19

<210> 66
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a inhibitor sequence

<400> 66
ctatacaacc tactacctc                                              19

<210> 67
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7c inhibitor sequence

<400> 67
catacaacct actacctc                                               18

<210> 68
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a inhibitor sequence

<400> 68
tatacaacct actacctc                                               18

<210> 69
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a/c inhibitor sequence

<400> 69
atacaaccta ctacctc                                                17

<210> 70
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a/c inhibitor sequence

<400> 70
atacaaccta ctacctc                                                17

<210> 71
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a/c inhibitor sequence

<400> 71
tacaacctac tacctc                                                 16

<210> 72
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a/c inhibitor sequence

<400> 72
tacaacctac tacctc                                                 16

<210> 73
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a/c inhibitor sequence

<400> 73
acaacctact acctc                                                  15

<210> 74
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a/c inhibitor sequence

<400> 74
acaacctact acctc                                                  15

<210> 75
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-100 inhibitor sequence

<400> 75
caagttcgga tctacgggt                                              19

<210> 76
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-99 inhibitor sequence

<400> 76
caagatcgga tctacgggt                                              19

<210> 77
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-99 inhibitor sequence

<400> 77
aagatcggat ctacgggt                                               18

<210> 78
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-100 inhibitor sequence

<400> 78
aagttcggat ctacgggt                                               18

<210> 79
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-99 inhibitor sequence

<400> 79
agatcggatc tacgggt                                                17

<210> 80
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-100 inhibitor sequence

<400> 80
agttcggatc tacgggt                                                17

<210> 81
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-99 inhibitor sequence

<400> 81
gatcggatct acgggt                                                 16

<210> 82
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-100 inhibitor sequence

<400> 82
gttcggatct acgggt                                                 16

<210> 83
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-99 inhibitor sequence

<400> 83
atcggatcta cgggt                                                  15

<210> 84
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-100 inhibitor sequence

<400> 84
ttcggatcta cgggt                                                  15

<210> 85
<211> 6558
<212> DNA
<213> Artificial Sequence

<220> 
<223> viral vector JBT-miR1

<400> 85
cggcctcagt gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg 60
cggccgcacg cgtctagtta ttaatagtaa tcgaattcgt gttactcata gcagatcacc 120
gctgctcgtc aactgaggcg cccaggcagt caggggactt cgtcgcccgg cctcagtgag 180
cgagcgcgca gcgagggagt ggcccacttc atcactaggc gttcctgcgg ccgcacgcgt 240
ctagttcact catagtaatc gaacttcgcg ttactcataa cagtgaacgc tgacgtcatc 300
aacccgctcc aaggaatcgc gggcccagtg tcactaggcg gggaacaccc agcgcgcgtg 360
cgccctggca ggaagatggc tgcgagggac aggggagtgg cgccccgcaa tattttccat 420
gtcggctatg tgttcttggg aaatcaccat aaacgtgaaa tgtctttgga tttgggaatc 480
ttataagttt ctgtatgaga ccactcggat ccgtgaggta gtaggttgta tagtttcaag 540
agaactatac aacctactac ctcatttttg agctcaaaaa aaacccgtag atccgatctt 600
gtgctcttga cacaagatcg gatctacggg tttcggtgtt cgcgtccttt ccacaagata 660
tataaaccca agaaatcgaa atactttcaa gttacggtaa gcatatgata gtccatttta 720
aaacataatt ttaaaactgc aaactaccca agaaattatt actttctacg tcacgtattt 780
tgtactaata tctttgtgtt tacagtcaaa ttaattctaa ttatctctct aacagccttg 840
tatcgtatat gcaaatatga aggaatcatg ggaaataggc cctcttcctg cccgaccttc 900
tgtcccctcc accccacgtc gacattaatg aagcttggcg actagtaata ctgtaatagt 960
aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta 1020
cggtaaatgg cccgcctggc tgaccgccca acgacccccg cctatatgca tggccccagg 1080
aaatcggaaa tagttcaagt tacggtaagc atatgatagt ccattttaaa acattatttt 1140
aaactgcaaa ctacccaaga aaattatact ttctacgtca cgtattttgt actaatatct 1200
ttgtgtttac agtcaaatta ttctaattat ctctcctaac agccttgtat cgtatatgca 1260
aatatgaacg gaatcatggg aaataggccc tcttcctgcc cgaccttctg tcccctccac 1320
cccacgtcga cgacaggatt ggtgacagag aacgctgacg tcatcaaccc gctccaagga 1380
atcgcgggcc cagtgtcact aggcgggaac acccagcgcg cgtgcgccct ggcaggaaga 1440
tggctgtgag ggacagggga gtggcgccct gcaatatttg catgtcgcta tgtgttctgg 1500
gaaatcacca taaacgtgaa atgtctttgg atttgggaat cttataagtt ctgtatgaga 1560
ccactcggat ccggtgaggt agtaggttgt atggtttcaa gagaaccata caacctacta 1620
cctcattttt gagctcaaaa aaaaacccgt agatccgaac ttgtgctctt gacacaagtt 1680
cggatctacg ggttcggtgt tcgcgtcctt tccacaagat atataaaccc aagaaatcga 1740
aatactttca agttacggta agcatatgat agtccatttt aaaacataat tttaaaactg 1800
caaactaccc aagaaattat tactttctac gtcacgtatt ttgtactaat atctttgtgt 1860
ttacagtcaa attaattcta attatctctc taacagcctt gtatcgtata tgcaaatatg 1920
aaggaatcat gggaaatagg ccctcttcct gcccgacctt aagcttggcg actagtaata 1980
ctgtaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt 2040
acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg ccccatgatg 2100
ccctagtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa 2160
tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt 2220
atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc 2280
ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat 2340
gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc 2400
ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc 2460
tccaccccat tgacgtcaat gggagtttgt tttgcaccaa aatcaacggg actttccaaa 2520
atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt 2580
ctatataagc agagctggtt tagtgaaccg tcagatccgc tagagatccg gtaccgagga 2640
gatctgccgc cgcgatcgcc ggcgcgccag atctcacgct taactagcta gcggaccgac 2700
gcgtacgcgg ccgctcgaga tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc 2760
catcctggtc gagctggacg gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg 2820
cgagggcgat gccacctacg gcaagctgac cctgaagttc atctgcacca ccggcaagct 2880
gcccgtgccc tggcccaccc tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg 2940
ctaccccgac cacatgaagc agcacgactt cttcaagtcc gccatgcccg aaggctacgt 3000
ccaggagcgc accatcttct tcaaggacga cggcaactac aagacccgcg ccgaggtgaa 3060
gttcgagggc gacaccctgg tgaaccgcat cgagctgaag ggcatcgact tcaaggagga 3120
cggcaacatc ctggggcaca agctggagta caactacaac agccacaacg tctatatcat 3180
ggccgacaag cagaagaacg gcatcaaggt gaacttcaag atccgccaca acatcgagga 3240
cggcagcgtg cagctcgccg accactacca gcagaacacc cccatcggcg acggccccgt 3300
gctgctgccc gacaaccact acctgagcac ccagtccgcc ctgagcaaag accccaacga 3360
gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc gccgggatca ctctcggcat 3420
ggacgagctg tacaagtaag tcgaggatta taaggatgac gacgataaat tcgtcgagca 3480
ccaccaccac caccactaat aaggtttatc cgatccaccg gatctagata agatatccga 3540
tccaccggat ctagataact gatcataatc agccatacca catttgtaga ggttttactt 3600
gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa tgcaattgtt 3660
gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat 3720
ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat 3780
gtatcttaac gcggtaacca cgtgcggacc gagcggccgc aggaacccct agtgatggag 3840
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc 3900
cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag 3960
gggcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatacgt 4020
caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta 4080
cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc 4140
cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt 4200
tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat ttgggtgatg 4260
gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca 4320
cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcgggct 4380
attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga 4440
tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt ttatggtgca 4500
ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac 4560
ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga 4620
ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac 4680
gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt 4740
agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct 4800
aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat 4860
attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg 4920
cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg 4980
aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc 5040
ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat 5100
gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact 5160
attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca 5220
tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact 5280
tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg 5340
atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg 5400
agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg 5460
aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg 5520
caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag 5580
ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc 5640
gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga 5700
tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat 5760
atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc 5820
tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag 5880
accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct 5940
gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac 6000
caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc 6060
tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg 6120
ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt 6180
tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt 6240
gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc 6300
tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca 6360
gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata 6420
gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg 6480
ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct 6540
ggccttttgc tcacatgt                                               6558

<210> 86
<211> 120
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a-5p sequence in vector JBT-miR2

<400> 86
gacggcgcta ggatcatcaa caactataca accaatgtac tacctcacaa gtattctggt 60
cacagaatac aacaactata caaccaatgt actacctcac aagatgatcc tagcgccgtc 120


<210> 87
<211> 120
<212> DNA
<213> Artificial Sequence

<220> 
<223> let-7a-5p Reverse Complement in vector JBT-miR2


<400> 87
gacggcgcta ggatcatctt gtgaggtagt acattggttg tatagttgtt gtattctgtg 60
accagaatac ttgtgaggta gtacattggt tgtatagttg ttgatgatcc tagcgccgtc 120


<210> 88
<211> 120
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-99a-5p sequence in vector JBT-miR2


<400> 88
gacggcgcta ggatcatcaa ccacaagatc ggaaatgtct acgggtacaa gtattctggt 60
cacagaatac aaccacaaga tcggaaatgt ctacgggtac aagatgatcc tagcgccgtc 120


<210> 89
<211> 120
<212> DNA
<213> Artificial Sequence

<220> 
<223> miR-99a-5p Reverse Complement in vector JBT-miR2

<400> 89
gacggcgcta ggatcatctt gtacccgtag acatttccga tcttgtggtt gtattctgtg 60
accagaatac ttgtacccgt agacatttcc gatcttgtgg ttgatgatcc tagcgccgtc 120


<210>  90
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-let-7a

<400>  90
ugagguagua gguuguauag uu                                                22


<210>  91
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-let-7c

<400>  91
ugagguagua gguuguaugg uu                                                22


<210>  92
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-100

<400>  92
aacccguaga uccgaacuug ug                                                22


<210>  93
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-99a

<400>  93
aacccguaga uccgaucuug ug                                                22


<210>  94
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HsU6R

<400>  94
gctaatcttc tctgtatcgt tcca                                              24


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HsU6F

<400>  95
ggatcagcgt ttgagtaaga g                                                 21


<210>  96
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human-U6-52

<400>  96
gcctatttcc catgattcct tc                                                22


<210>  97
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human-U6-32

<400>  97
ggtgtttcgt cctttccac                                                    19


<210>  98
<211>  1096
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TUD cassette inserted into pAV-U6-GFP


<220>
<221>  U6 promoter
<222>  (1)..(241)

<220>
<221>  miR-99a TuD
<222>  (412)..(531)

<220>
<221>  let-7a/c TuD
<222>  (550)..(669)

<220>
<221>  H1 Promoter
<222>  (678)..(892)

<220>
<221>  ITR
<222>  (950)..(1036)

<400>  98
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttgggtt tatatatctt gtggaaagga      240

ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa tttcttgggt      300

agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc gtaacttgaa      360

agtatttcga tttcttgggt ttatatatct tgtggaaagg acgcgaacac cgacggcgct      420

aggatcatct tgtacccgta gacatttccg atcttgtggt tgtattctgt gaccagaata      480

cttgtacccg tagacatttc cgatcttgtg gttgatgatc ctagcgccgt cttttttgag      540

ctcaaaaaag acggcgctag gatcatcaac aactatacaa ccaatgtact acctcacaag      600

tattctggtc acagaataca acaactatac aaccaatgta ctacctcaca agatgatcct      660

agcgccgtcg gatccgagtg gtctcataca gaacttataa gattcccaaa tccaaagaca      720

tttcacgttt atggtgattt cccagaacac atagcgacat gcaaatattg cagggcgcca      780

ctcccctgtc cctcacagcc atcttcctgc cagggcgcac gcgcgctggg tgttcccgcc      840

tagtgacact gggcccgcga ttccttggag cgggttgatg acgtcagcgt tcactagtta      900

tgagtaacac gaattcgatt actattaata actagacgcg tgcggccgca ggaaccccta      960

gtgatggagt tggccactcc ctctctgcgc gctcgctcac tgaggccggg cgaccaaagg     1020

tcgcccgacg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct gcaggacatg     1080

tgagcaaaag gccagc                                                     1096


<210>  99
<211>  2308
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Albumin Stuffer Design 1


<220>
<221>  ITR
<222>  (154)..(180)

<220>
<221>  U6 Promoter
<222>  (340)..(580)

<220>
<221>  miR-99a
<222>  (751)..(870)

<220>
<221>  let-7a/c
<222>  (889)..(1008)

<220>
<221>  H1 Promoter
<222>  (1017)..(1231)

<220>
<221>  ITR
<222>  (2168)..(2308)

<400>  99
ccactccctc tatgcgcgct cgctcactca ctcggccctg gagaccaaag gtctccagac       60

tgccggcctc tggccggcag ggccgagtga gtgagcgagc gcgcatagag ggagtgggta      120

cctccatcat ctaggtttgc ccctgcaggc agctgcgcgc tcgctcgctc actgaggccg      180

cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgcgc agagagggag      240

tggccaactc catcactagg ggttcctgcg gccgcacgcg tctagttatt aatagtaatc      300

gaattcgtgt tactcataac tagtaaggtc gggcaggaag agggcctatt tcccatgatt      360

ccttcatatt tgcatatacg atacaaggct gttagagaga taattagaat taatttgact      420

gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag      480

tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag      540

tatttcgatt tcttgggttt atatatcttg tggaaaggac tgtaaacaca aagatattag      600

tacaaaatac gtgacgtaga aagtaataat ttcttgggta gtttgcagtt ttaaaattat      660

gttttaaaat ggactatcat atgcttaccg taacttgaaa gtatttcgat ttcttgggtt      720

tatatatctt gtggaaagga cgcgaacacc gacggcgcta ggatcatctt gtacccgtag      780

acatttccga tcttgtggtt gtattctgtg accagaatac ttgtacccgt agacatttcc      840

gatcttgtgg ttgatgatcc tagcgccgtc ttttttgagc tcaaaaaaga cggcgctagg      900

atcatcaaca actatacaac caatgtacta cctcacaagt attctggtca cagaatacaa      960

caactataca accaatgtac tacctcacaa gatgatccta gcgccgtcgg atccgagtgg     1020

tctcatacag aacttataag attcccaaat ccaaagacat ttcacgttta tggtgatttc     1080

ccagaacaca tagcgacatg caaatattgc agggcgccac tcccctgtcc ctcacagcca     1140

tcttcctgcc agggcgcacg cgcgctgggt gttcccgcct agtgacactg ggcccgcgat     1200

tccttggagc gggttgatga cgtcagcgtt cactagttat gagtaacacg aattcgatta     1260

ctattaataa ctagacgcgt gcggccgcag gaacccctag tgatggagtt ggccactccc     1320

tctctgcgcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggcggcc     1380

tcagtgagcg agcgagcgcg cagctgcctg caggacatgt gagcaaaagg ccagccaaca     1440

aaatcagcag ctaatgaagg caagtcagca ggtcactcat cattttccac ttcggcaatg     1500

cagtgggatt attccaacag aggtttttca cagcattcct tcagttaact ggagatcgaa     1560

tcttgatttt cacagatata cttggcaagg tccgccctgt catcagcaca ttcaagcaga     1620

tctccatggc agcattccgt gtggacttag gtaagatctg tcactaactt ggaaacttct     1680

gcaaactcag cttagggaaa tctctggctc aggcgagcta ctgcctcagc ttagaaagct     1740

ctttctccaa attattggag actggcacac ttaagtccct gttaggcaga cgaagccttc     1800

ccttcatccc gaagttcatc gagctttggc aacaggcagg cagctttatc agcagcttgg     1860

caacattctg taaaagcagc tttatacctt taagcaaaga aaaggagttc cggggcataa     1920

aagtaaggat gtcttctggc aatttataat aagtattttt tcaaaaatgt ctcttcattg     1980

tcatgaaaag cagtgcatca cacatcaacc tctggtctca ccaatcgggg gaggtttggg     2040

ttgtttactt agtgttgcaa gaattatttt attctctcag gttcttgttt tgcacagcag     2100

tcagctcatt caccataggt ttcacgaaga gttgcacgcg gtaaccacgt gcggaccgag     2160

cggccgcagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     2220

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     2280

agcgagcgag cgcgcagctg cctgcagg                                        2308


<210>  100
<211>  3593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ADD Stuffer Design 2


<220>
<221>  ITR
<222>  (154)..(180)

<220>
<221>  U6 Promoter
<222>  (340)..(580)

<220>
<221>  miR-99a
<222>  (751)..(870)

<220>
<221>  let-7a/c
<222>  (889)..(1008)

<220>
<221>  H1 Promoter
<222>  (1017)..(1231)

<220>
<221>  ITR
<222>  (3453)..(3593)

<400>  100
ccactccctc tatgcgcgct cgctcactca ctcggccctg gagaccaaag gtctccagac       60

tgccggcctc tggccggcag ggccgagtga gtgagcgagc gcgcatagag ggagtgggta      120

cctccatcat ctaggtttgc ccctgcaggc agctgcgcgc tcgctcgctc actgaggccg      180

cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgcgc agagagggag      240

tggccaactc catcactagg ggttcctgcg gccgcacgcg tctagttatt aatagtaatc      300

gaattcgtgt tactcataac tagtaaggtc gggcaggaag agggcctatt tcccatgatt      360

ccttcatatt tgcatatacg atacaaggct gttagagaga taattagaat taatttgact      420

gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag      480

tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag      540

tatttcgatt tcttgggttt atatatcttg tggaaaggac tgtaaacaca aagatattag      600

tacaaaatac gtgacgtaga aagtaataat ttcttgggta gtttgcagtt ttaaaattat      660

gttttaaaat ggactatcat atgcttaccg taacttgaaa gtatttcgat ttcttgggtt      720

tatatatctt gtggaaagga cgcgaacacc gacggcgcta ggatcatctt gtacccgtag      780

acatttccga tcttgtggtt gtattctgtg accagaatac ttgtacccgt agacatttcc      840

gatcttgtgg ttgatgatcc tagcgccgtc ttttttgagc tcaaaaaaga cggcgctagg      900

atcatcaaca actatacaac caatgtacta cctcacaagt attctggtca cagaatacaa      960

caactataca accaatgtac tacctcacaa gatgatccta gcgccgtcgg atccgagtgg     1020

tctcatacag aacttataag attcccaaat ccaaagacat ttcacgttta tggtgatttc     1080

ccagaacaca tagcgacatg caaatattgc agggcgccac tcccctgtcc ctcacagcca     1140

tcttcctgcc agggcgcacg cgcgctgggt gttcccgcct agtgacactg ggcccgcgat     1200

tccttggagc gggttgatga cgtcagcgtt cactagttat gagtaacacg aattcgatta     1260

ctattaataa ctagacgcgt gcggccgcag gaacccctag tgatggagtt ggccactccc     1320

tctctgcgcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggcggcc     1380

tcagtgagcg agcgagcgcg cagctgcctg caggacatgt gagcaaaagg ccagccgttt     1440

agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc atagaagaca     1500

ccgggaccga tccagcctcc ggactctaga gagacgtaca aaaaagagca agaagctaaa     1560

aaagatttaa aaattatttt tagcgcagtt aatggaacag gaactaaatt taccccaaaa     1620

atattacgtg aatcaggata taacgttatt gaggttgaag agcatgcatt tgaagatgaa     1680

acatttaaaa atgttgtaaa tccaaatcca gaatttgatc ctgcatgaaa aataccgctt     1740

gaatatggta ttaaacatga tgcagatatt attattatga atgacccaga tgctgacaga     1800

tttggaatgg caataaaaca tgatggtcat tttgtaagat tagatggaaa tcaaacagga     1860

ccaattttaa ttgattgaaa attatcaaat ctaaaacgct taaatagcat tccaaaaaat     1920

ccggctctat attcaagttt tgtaacaagt gatttgggtg atagaatcgc tcatgaaaaa     1980

tatggagtta atattgtaaa aactttaact ggatttaaat gaatgggtag agaaattgct     2040

aaagaagaag ataacggatt aaattttgtt tttgcttatg aagaaagtta tggatatgta     2100

attgatgact cagctagaga taaagatgga atacaagctt ctatattaat agcagaggct     2160

gcttgatttt ataaaaaaca aaataaaaca ttagtagact atttagaaga tttatttaaa     2220

gaaatgggtg catattacac tttcacttta aacttgaatt ttaaaccaga agaaaagaaa     2280

ttaaaaattg aaccattaat gaaatcattg agagcaacac ccttaactca aattgctgga     2340

cttaaagttg ttaatgttga agactacatc gatggaatgt ataatatgcc aggacaagac     2400

ttactaaaat tttatttaga agataagtca tgatttgctg ttcgcccaag tggaactgaa     2460

cctaaactaa aaatttattt tataggtgtt ggtgaatctg ttcaaaacgc taaagttaaa     2520

gtagacgaaa ttattaaaga attaaaatta aaaatgaata tataggagaa aaaatgaaac     2580

taaacaaata tatagatcac acattattaa aacaagatgc tacgaaagct gaaattaaac     2640

aattatgtga tgaagcaatt gaatttgatt ttgcaacagt ttgtgttaat tcatattgaa     2700

caagctattg taaagaatta ttaaaaggca caaatgtagg aataacaaat gttgtaggtt     2760

ttcctctagg tgcatgcaca acagctacaa aagcattcga agtttctgaa gcaattaaag     2820

atggtgcaac agaaattgat atggtattaa atattggtgc attaaaagac aaaaattatg     2880

aattagtttt agaagacatg aaagctgtaa aaaaagcagc tggatcacat gttgttaaat     2940

gtattatgga aaattgttta ttaacaaaag aagaaatcat gaaagcttgt gaaatagctg     3000

ttgaagctgg attagaattt gttaaaacat caacaggatt ttcaaaatca ggtgcaacat     3060

ttgaagatgt taaactaatg aagtcagttg ttaaagacaa tgctttagtt aaagcagctg     3120

gtggagttag aacatttgaa gatgctcaaa aaatgattga agcaggagct gaccgcttag     3180

gaacaagtgg tggagtagct attattaaag gtgaagaaaa caacgcgagt tactaaaact     3240

agcgtttttt tattttgctc atttttatta aaagtttgca aaaaggaaca taaaaattct     3300

aattattgat actaaagtta ttaaaaagaa gattttggtt gattttataa aggtcataga     3360

atataatatt ttagcatgtg tattttgtgt gctcatttac aaccgtctcg cggccgcggg     3420

acgcggtaac cacgtgcgga ccgagcggcc gcaggaaccc ctagtgatgg agttggccac     3480

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     3540

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agctgcctgc agg            3593


<210>  101
<211>  1604
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Partial JBT-miR2 viral sequence


<220>
<221>  U6 Promoter
<222>  (251)..(491)

<220>
<221>  miR-99a
<222>  (501)..(620)

<220>
<221>  let-7a/c
<222>  (639)..(758)

<220>
<221>  H1 Promoter
<222>  (767)..(981)

<400>  101
agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca       60

ttgacgtcaa tgggcggggg tcgttgggcg gtcagccagg cgggccattt accgtaagtt      120

atgtaacgcg gaactccata tatgggctat gaactaatga ccccgtaatt gattactatt      180

acagtattac tagtcgccaa gcttcattaa tgtcgacgtg gggtggaggg gacagaaggt      240

cgggcaggaa gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc      300

tgttagagag ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac      360

gtgacgtaga aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat      420

ggactatcat atgcttaccg taacttgaaa gtatttcgat ttcttgggtt tatatatctt      480

gtggaaagga cgcgaacacc gacggcgcta ggatcatctt gtacccgtag acatttccga      540

tcttgtggtt gtattctgtg accagaatac ttgtacccgt agacatttcc gatcttgtgg      600

ttgatgatcc tagcgccgtc ttttttgagc tcaaaaaaga cggcgctagg atcatcaaca      660

actatacaac caatgtacta cctcacaagt attctggtca cagaatacaa caactataca      720

accaatgtac tacctcacaa gatgatccta gcgccgtcgg atccgagtgg tctcatacag      780

aacttataag attcccaaat ccaaagacat ttcacgttta tggtgatttc ccagaacaca      840

tagcgacatg caaatattgc agggcgccac tcccctgtcc ctcacagcca tcttcctgcc      900

agggcgcacg cgcgctgggt gttcccgcct agtgacactg ggcccgcgat tccttggagc      960

gggttgatga cgtcagcgtt cactagttat gagtaacacg aattcgatta ctattaataa     1020

ctagacgcgt gcggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg     1080

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggcggcc tcagtgagcg     1140

agcgagcgcg cagctgcctg caggacatgt gagcaaaagg ccagcaaaag gccaggaacc     1200

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     1260

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     1320

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     1380

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     1440

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     1500

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     1560

tatcgccact ggcagcagcc actggtaact gagggcctat ttcc                      1604